{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:34:29Z","timestamp":1786372469200,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013066","name":"Key Scientific Research Project of Colleges and Universities in Henan Province","doi-asserted-by":"publisher","award":["25A310023"],"award-info":[{"award-number":["25A310023"]}],"id":[{"id":"10.13039\/501100013066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001632","name":"Ulster University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001632","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274612"],"award-info":[{"award-number":["82274612"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.peptides.2026.171501","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:08:18Z","timestamp":1781737698000},"page":"171501","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["P1642-1, a novel pancreatic polypeptide analogue, ameliorates cognitive impairment in 5\u202f\u00d7FAD mice and is associated with enhanced PINK1\/Parkin-related mitophagy"],"prefix":"10.1016","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1808-2258","authenticated-orcid":false,"given":"Huan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinuo","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enhua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Flatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Gault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Irwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"H\u00f6lscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2026.171501_bib1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/B978-0-12-804766-8.00013-3","article-title":"Alzheimer's disease","volume":"167","author":"Soria Lopez","year":"2019","journal-title":"Handb. Clin. Neurol."},{"issue":"2","key":"10.1016\/j.peptides.2026.171501_bib2","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/alz.12694","article-title":"Global estimates on the number of persons across the Alzheimer's disease continuum","volume":"19","author":"Gustavsson","year":"2023","journal-title":"Alzheimer's. & Dement."},{"key":"10.1016\/j.peptides.2026.171501_bib3","doi-asserted-by":"crossref","unstructured":"2024 Alzheimer's disease facts and figures 5 20 Alzheimers Dement.2024, Alzheimer's disease facts and figures202437083821.","DOI":"10.1002\/alz.13809"},{"key":"10.1016\/j.peptides.2026.171501_bib4","unstructured":"L. Clare, Y. Jeon, World Alzheimer report 2025: reimagining life with dementia\u2014the power of rehabilitation, Alzheimer\u2019s Disease International, London, England (2025)."},{"issue":"10","key":"10.1016\/j.peptides.2026.171501_bib5","doi-asserted-by":"crossref","first-page":"5169","DOI":"10.3390\/ijms25105169","article-title":"Advances in therapeutics to alleviate cognitive decline and neuropsychiatric symptoms of Alzheimer\u2019s disease","volume":"25","author":"Li","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.peptides.2026.171501_bib6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa2212948","article-title":"Lecanemab in early Alzheimer's disease","volume":"388","author":"van Dyck","year":"2023","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.peptides.2026.171501_bib7","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1001\/jama.2023.13239","article-title":"Donanemab in early symptomatic Alzheimer disease: the TRAILBLAZER-ALZ 2 randomized clinical trial","volume":"330","author":"Sims","year":"2023","journal-title":"Jama"},{"issue":"2","key":"10.1016\/j.peptides.2026.171501_bib8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/procel\/pwae026","article-title":"Alzheimer's disease: insights into pathology, molecular mechanisms, and therapy","volume":"16","author":"Zheng","year":"2025","journal-title":"Protein Cell."},{"issue":"4","key":"10.1016\/j.peptides.2026.171501_bib9","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cell.2005.02.008","article-title":"Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective","volume":"120","author":"Tanzi","year":"2005","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.peptides.2026.171501_bib10","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/cne.902480307","article-title":"Distribution of altered hippocampal neurons and axons immunoreactive with antisera against neuropeptide Y in Alzheimer's-type dementia","volume":"248","author":"Chan-Palay","year":"1986","journal-title":"J. Comp. Neurol."},{"issue":"4","key":"10.1016\/j.peptides.2026.171501_bib11","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/cne.902380404","article-title":"Cortical neurons immunoreactive with antisera against neuropeptide Y are altered in Alzheimer's-type dementia","volume":"238","author":"Chan-Palay","year":"1985","journal-title":"J. Comp. Neurol."},{"issue":"12","key":"10.1016\/j.peptides.2026.171501_bib12","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/S0196-9781(01)00571-X","article-title":"Processing of neuropeptide Y, galanin, and somatostatin in the cerebrospinal fluid of patients with Alzheimer's disease and frontotemporal dementia","volume":"22","author":"Nilsson","year":"2001","journal-title":"Peptides"},{"issue":"9","key":"10.1016\/j.peptides.2026.171501_bib13","article-title":"ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer's disease through BDNF\/NGFR signaling","volume":"4","author":"Tayran","year":"2024","journal-title":"Cell. Genom."},{"issue":"4","key":"10.1016\/j.peptides.2026.171501_bib14","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1523\/JNEUROSCI.4220-08.2009","article-title":"Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease","volume":"29","author":"Rose","year":"2009","journal-title":"J. Neurosci."},{"issue":"8","key":"10.1016\/j.peptides.2026.171501_bib15","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1111\/j.1460-9568.2008.06172.x","article-title":"Interaction between neuropeptide Y (NPY) and brain-derived neurotrophic factor in NPY-mediated neuroprotection against excitotoxicity: a role for microglia","volume":"27","author":"Xapelli","year":"2008","journal-title":"Eur. J. Neurosci."},{"issue":"6","key":"10.1016\/j.peptides.2026.171501_bib16","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/S0016-5085(83)80027-4","article-title":"Pancreatic polypeptide: a hormone under vagal control","volume":"85","author":"Schwartz","year":"1983","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.peptides.2026.171501_bib17","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1159\/000486225","article-title":"A promising therapeutic target for metabolic diseases: neuropeptide y receptors in humans","volume":"45","author":"Yi","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"45","key":"10.1016\/j.peptides.2026.171501_bib18","doi-asserted-by":"crossref","first-page":"26762","DOI":"10.1074\/jbc.270.45.26762","article-title":"Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY","volume":"270","author":"Bard","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.peptides.2026.171501_bib19","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0091-3057(94)00412-C","article-title":"J.B. Jaspan, Regional variation in transport of pancreatic polypeptide across the blood-brain barrier of mice","volume":"51","author":"Banks","year":"1995","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"10","key":"10.1016\/j.peptides.2026.171501_bib20","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1136\/gut.19.10.907","article-title":"Pharmacokinetics of pancreatic polypeptide in man","volume":"19","author":"Adrian","year":"1978","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.peptides.2026.171501_bib21","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/biof.2059","article-title":"Novel enzyme-resistant pancreatic polypeptide analogs evoke pancreatic beta-cell rest, enhance islet cell turnover, and inhibit food intake in mice","volume":"50","author":"Zhu","year":"2024","journal-title":"Biofactors"},{"key":"10.1016\/j.peptides.2026.171501_bib22","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-2202-13-33","article-title":"Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis","volume":"13","author":"Hunter","year":"2012","journal-title":"BMC Neurosci."},{"issue":"3","key":"10.1016\/j.peptides.2026.171501_bib23","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3810\/pgm.2009.05.1998","article-title":"Insights from the liraglutide clinical development program--the liraglutide effect and action in diabetes (LEAD) studies","volume":"121","author":"McGill","year":"2009","journal-title":"Postgrad. Med."},{"key":"10.1016\/j.peptides.2026.171501_bib24","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neuropharm.2013.08.005","article-title":"Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP\/PS1 mice, a model of Alzheimer's disease","volume":"76","author":"McClean","year":"2014","journal-title":"Neuropharmacology"},{"issue":"S9","key":"10.1016\/j.peptides.2026.171501_bib25","doi-asserted-by":"crossref","DOI":"10.1002\/alz.057848","article-title":"Evaluation of liraglutide in the treatment of Alzheimer's disease","volume":"17","author":"Edison","year":"2021","journal-title":"Alzheimer's. & Dement."},{"key":"10.1016\/j.peptides.2026.171501_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/alz.080538","article-title":"Mri changes following treatment of Glp-1 analogue, liraglutide in Alzheimer\u2019S disease","volume":"19","author":"Edison","year":"2023","journal-title":"Alzheimer's. & Dement."},{"issue":"2","key":"10.1016\/j.peptides.2026.171501_bib27","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.devcel.2011.12.014","article-title":"Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin","volume":"22","author":"Lazarou","year":"2012","journal-title":"Dev. Cell."},{"issue":"1","key":"10.1016\/j.peptides.2026.171501_bib28","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.molcel.2021.11.012","article-title":"Mechanism of PINK1 activation by autophosphorylation and insights into assembly on the TOM complex","volume":"82","author":"Rasool","year":"2022","journal-title":"Mol. Cell."},{"issue":"3","key":"10.1016\/j.peptides.2026.171501_bib29","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.molcel.2014.09.007","article-title":"Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis","volume":"56","author":"Ordureau","year":"2014","journal-title":"Mol. Cell."},{"issue":"7565","key":"10.1016\/j.peptides.2026.171501_bib30","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nature14893","article-title":"The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy","volume":"524","author":"Lazarou","year":"2015","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.peptides.2026.171501_bib31","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1093\/hmg\/ddv056","article-title":"Parkin-mediated mitophagy in mutant hAPP neurons and Alzheimer's disease patient brains","volume":"24","author":"Ye","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.peptides.2026.171501_bib32","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fncel.2016.00024","article-title":"Alterations in mitochondrial quality control in Alzheimer's disease","volume":"10","author":"Cai","year":"2016","journal-title":"Front. Cell. Neurosci."},{"issue":"17","key":"10.1016\/j.peptides.2026.171501_bib33","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1093\/hmg\/ddp258","article-title":"Parkin promotes intracellular Abeta1-42 clearance","volume":"18","author":"Burns","year":"2009","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.peptides.2026.171501_bib34","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s40001-022-00862-1","article-title":"Neuroprotective effects of donepezil against A\u03b225-35-induced neurotoxicity","volume":"27","author":"Gao","year":"2022","journal-title":"Eur. J. Med. Res."},{"issue":"5","key":"10.1016\/j.peptides.2026.171501_bib35","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1007\/s11011-019-00447-8","article-title":"Amyloid beta 25\u201335 induces blood-brain barrier disruption in vitro","volume":"34","author":"Cuevas","year":"2019","journal-title":"Metab. brain Dis."},{"issue":"8016","key":"10.1016\/j.peptides.2026.171501_bib36","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"},{"issue":"40","key":"10.1016\/j.peptides.2026.171501_bib37","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.peptides.2026.171501_bib38","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1750-1326-8-2","article-title":"Neuron loss in the 5XFAD mouse model of Alzheimer's disease correlates with intraneuronal A\u03b242 accumulation and Caspase-3 activation","volume":"8","author":"Eimer","year":"2013","journal-title":"Mol. Neurodegener."},{"issue":"2","key":"10.1016\/j.peptides.2026.171501_bib39","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00401-015-1386-3","article-title":"Amyloid \u03b2 oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis","volume":"129","author":"Viola","year":"2015","journal-title":"Acta Neuropathol."},{"issue":"6","key":"10.1016\/j.peptides.2026.171501_bib40","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/jnc.15007","article-title":"A mechanistic hypothesis for the impairment of synaptic plasticity by soluble A\u03b2 oligomers from Alzheimer's brain","volume":"154","author":"Li","year":"2020","journal-title":"J. Neurochem."},{"key":"10.1016\/j.peptides.2026.171501_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117144","article-title":"Phytochemicals targeting mitophagy: Therapeutic opportunities and prospects for treating Alzheimer's disease","volume":"177","author":"Yang","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.peptides.2026.171501_bib42","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1471-4159.2011.07581.x","article-title":"Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease","volume":"120","author":"Sheng","year":"2012","journal-title":"J. Neurochem."},{"issue":"7","key":"10.1016\/j.peptides.2026.171501_bib43","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1111\/cns.13140","article-title":"Mechanisms and roles of mitophagy in neurodegenerative diseases","volume":"25","author":"Wang","year":"2019","journal-title":"CNS Neurosci. Ther."},{"issue":"3","key":"10.1016\/j.peptides.2026.171501_bib44","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41593-018-0332-9","article-title":"Mitophagy inhibits amyloid-\u03b2 and tau pathology and reverses cognitive deficits in models of Alzheimer's disease","volume":"22","author":"Fang","year":"2019","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.peptides.2026.171501_bib45","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00401-020-02234-7","article-title":"Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer's disease models and human brains","volume":"141","author":"Vaillant-Beuchot","year":"2021","journal-title":"Acta Neuropathol."},{"issue":"10","key":"10.1016\/j.peptides.2026.171501_bib46","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1101\/gad.262758.115","article-title":"The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications","volume":"29","author":"Durcan","year":"2015","journal-title":"Genes. Dev."},{"issue":"21","key":"10.1016\/j.peptides.2026.171501_bib47","doi-asserted-by":"crossref","first-page":"6637","DOI":"10.1073\/pnas.1506593112","article-title":"Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy","volume":"112","author":"Ordureau","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978126000380?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978126000380?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:32:17Z","timestamp":1786368737000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978126000380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":47,"alternative-id":["S0196978126000380"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2026.171501","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"P1642-1, a novel pancreatic polypeptide analogue, ameliorates cognitive impairment in 5\u202f\u00d7FAD mice and is associated with enhanced PINK1\/Parkin-related mitophagy","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2026.171501","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"171501"}}