{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:55:08Z","timestamp":1790740508531,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pesticide Biochemistry and Physiology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.pestbp.2015.03.007","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T08:09:00Z","timestamp":1428307740000},"page":"74-86","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["NADPH oxidase mediated maneb- and paraquat-induced oxidative stress in rat polymorphs: Crosstalk with mitochondrial dysfunction"],"prefix":"10.1016","volume":"123","author":[{"given":"Smriti","family":"Shukla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepali","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit Kumar","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israr","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haushila Prasad","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetna","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pestbp.2015.03.007_bib0010","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.brainres.2006.01.060","article-title":"Status of antioxidant defense system and expression of toxicant responsive genes in striatum of maneb- and paraquat-induced Parkinson's disease phenotype in mouse: mechanism of neurodegeneration","volume":"1081","author":"Patel","year":"2006","journal-title":"Brain Res"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0015","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/aje\/kwp006","article-title":"Parkinson's disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California","volume":"169","author":"Costello","year":"2009","journal-title":"Am. J. Epidemiol"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0020","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/cdd.2009.217","article-title":"Paraquat and Parkinson's disease","volume":"17","author":"Berry","year":"2010","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0025","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1007\/s11064-010-0176-5","article-title":"Involvement of nitric oxide in maneb- and paraquat-induced Parkinson's disease phenotype in mouse: is there any link with lipid peroxidation?","volume":"35","author":"Gupta","year":"2010","journal-title":"Neurochem. Res"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0030","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.brainres.2007.06.046","article-title":"Cytotoxicity of paraquat in microglial cells: involvement of PKCdelta- and ERK1\/2-dependent NADPH oxidase","volume":"1167","author":"Miller","year":"2007","journal-title":"Brain Res"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0035","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s11010-014-2062-y","article-title":"CYP2E1-mediated oxidative stress regulates HO-1 and GST expression in maneb- and paraquat-treated rat polymorphonuclear leukocytes","volume":"393","author":"Ahmad","year":"2014","journal-title":"Mol. Cell. Biochem"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0040","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.molbrainres.2004.11.005","article-title":"Redox cycling of the herbicide paraquat in microglial cultures","volume":"134","author":"Bonneh-Barkay","year":"2005","journal-title":"Brain Res. Mol. Brain Res"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0045","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/S0891-5849(02)01169-3","article-title":"Catalysis of catechol oxidation by metal-dithiocarbamate complexes in pesticides","volume":"33","author":"Fitsnakis","year":"2002","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0050","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1046\/j.1471-4159.2003.01525.x","article-title":"Manganese ethylene-bis-dithiocarbamate and selective dopaminergic neurodegeneration in rat: a link through mitochondrial dysfunction","volume":"84","author":"Zhang","year":"2003","journal-title":"J. Neurochem"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0055","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.neuro.2006.07.009","article-title":"Acute neurotoxic effects of mancozeb and maneb in mesencephalic cells are associated with mitochondrial dysfunction","volume":"27","author":"Domico","year":"2006","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0060","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.freeradbiomed.2009.12.022","article-title":"Reactive oxygen species, cellular redox systems and apoptosis","volume":"48","author":"Circu","year":"2010","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0065","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1089\/ars.2009.2459","article-title":"The role of NADPH oxidase 1-derived reactive oxygen species in paraquat-mediated dopaminergic cell death","volume":"11","author":"Cristovao","year":"2009","journal-title":"Antioxid. Redox Signal"},{"issue":"19","key":"10.1016\/j.pestbp.2015.03.007_bib0070","doi-asserted-by":"crossref","first-page":"14186","DOI":"10.1074\/jbc.M700827200","article-title":"Mitochondria are a major source of paraquat-induced reactive oxygen species production in the brain","volume":"282","author":"Castello","year":"2007","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0075","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/toxsci\/kfp223","article-title":"Differential contribution of the mitochondrial respiratory chain complexes to reactive oxygen species production by redox cycling agents implicated in Parkinsonism","volume":"112","author":"Drechsel","year":"2009","journal-title":"Toxicol. Sci"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0080","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.brainres.2011.12.028","article-title":"Involvement of NADPH oxidase and glutathione in zinc-induced dopaminergic neurodegeneration in rats: similarity with paraquat neurotoxicity","volume":"1438","author":"Kumar","year":"2012","journal-title":"Brain Res"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0085","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/S0891-5849(00)00229-X","article-title":"Myeloperoxidase-generated oxidants and artherosclerosis","volume":"28","author":"Podrez","year":"2000","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0090","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.7883\/yoken.JJID.2004.S24","article-title":"Molecular mechanism underlying activation of superoxide-producing NADPH oxidases: roles for their regulatory proteins","volume":"57","author":"Sumimoto","year":"2004","journal-title":"Jpn. J. Infect. Dis"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0095","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3181\/00379727-203-43600A","article-title":"Superoxide dismutase and pulmonary oxygen toxicity","volume":"203","author":"Tsan","year":"1993","journal-title":"Proc. Soc. Exp. Biol. Med"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0100","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1007\/s11095-013-1113-5","article-title":"Superoxide dismutase administration, a potential therapy against oxidative stress related diseases: several routes of supplementation and proposal of an original mechanism of action","volume":"30","author":"Carillon","year":"2013","journal-title":"Pharm. Res"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0105","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0304-3940(02)01168-0","article-title":"The role of oxidative stress in paraquat-induced neurotoxicity in rats: protection by non peptidyl superoxide dismutase mimetic","volume":"335","author":"Mollace","year":"2003","journal-title":"Neurosci. Lett"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0110","doi-asserted-by":"crossref","first-page":"29194","DOI":"10.1074\/jbc.M500984200","article-title":"Superoxide dismutase\/catalase mimetics are neuroprotective against selective paraquat-mediated dopaminergic neuron death in the substantial nigra: implications for Parkinson's disease","volume":"280","author":"Peng","year":"2005","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0115","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.tibs.2010.04.002","article-title":"Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes","volume":"35","author":"Hamanaka","year":"2010","journal-title":"Trends Biochem. Sci"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0120","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s13105-014-0359-7","article-title":"Cypermethrin alters the status of oxidative stress in the peripheral blood: relevance to Parkinsonism","volume":"70","author":"Tripathi","year":"2014","journal-title":"J. Physiol. Biochem"},{"issue":"10","key":"10.1016\/j.pestbp.2015.03.007_bib0125","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1080\/10715760802513733","article-title":"The involvement of nitric oxide in maneb and paraquat induced oxidative stress in rat polymorphonuclear leukocytes","volume":"42","author":"Ahmad","year":"2008","journal-title":"Free Radic. Res"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0130","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.freeradbiomed.2011.06.033","article-title":"Crosstalk between mitochondria and NADPH oxidases","volume":"51","author":"Dikalov","year":"2011","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0135","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1089\/ars.2012.4609","article-title":"Mitochondrial redox signaling: interaction of mitochondrial reactive oxygen species with other sources of oxidative stress","volume":"20","author":"Schulz","year":"2014","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0140","doi-asserted-by":"crossref","first-page":"3414","DOI":"10.1523\/JNEUROSCI.19-09-03414.1999","article-title":"Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome C and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice","volume":"19","author":"Fujimura","year":"1999","journal-title":"J. Neurosci"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0145","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S1046-2023(02)00039-7","article-title":"Measuring mitochondrial reactive oxygen species","volume":"26","author":"Esposti","year":"2002","journal-title":"Methods"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0150","doi-asserted-by":"crossref","first-page":"18092","DOI":"10.1074\/jbc.273.29.18092","article-title":"Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes","volume":"273","author":"Vanden Hoek","year":"1998","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0155","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0076-6879(94)33025-5","article-title":"Assays of plasma membrane NADPH oxidase","volume":"233","author":"Jones","year":"1994","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0160","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.3109\/10715762.2011.607164","article-title":"Oxidative stress in zinc-induced dopaminergic neurodegeneration: implications of superoxide dismutase and heme oxygenase-1","volume":"45","author":"Singh","year":"2011","journal-title":"Free Radic. Res"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0165","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s10875-004-6243-4","article-title":"Oxidative stress level in circulating neutrophils is linked to neurodegenerative diseases","volume":"24","author":"Vitte","year":"2004","journal-title":"J. Clin. Immunol"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0170","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1539\/joh.49.242","article-title":"Differential expression of EC-SOD, Mn-SOD and CuZn-SOD in rat lung exposed to crystalline silica","volume":"49","author":"Kim","year":"2007","journal-title":"J. Occup. Health"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0175","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1095\/biolreprod59.1.208","article-title":"Differential regulation of copper-zinc superoxide dismutase and manganese superoxide dismutase in the rat corpus luteum: induction of manganese superoxide dismutase messenger ribonucleic acid by inflammatory cytokines","volume":"59","author":"Sugino","year":"1998","journal-title":"Biol. Reprod"},{"issue":"6","key":"10.1016\/j.pestbp.2015.03.007_bib0180","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1152\/ajprenal.00218.2001","article-title":"Production of superoxide through NADH oxidase in thick ascending limb of Henle's loop in rat kidney","volume":"282","author":"Li","year":"2002","journal-title":"Am. J. Physiol. Renal Physiol"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0185","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0006-291X(74)80481-X","article-title":"Superoxide and singlet oxygen-catalyzed lipid peroxidation as a possible mechanism for paraquat (methyl violagen) toxicity","volume":"58","author":"Bus","year":"1974","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0190","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.neuro.2007.04.008","article-title":"Reactive oxygen species generation by the ethylenebis-dithiocarbamate (EBDC) fungicide mancozeb and its contribution to neuronal toxicity in mesencephalic cells","volume":"28","author":"Domico","year":"2007","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0195","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.tox.2006.12.005","article-title":"Mouse model of paraquat-poisoned lungs and its gene expression profile","volume":"231","author":"Tomita","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0200","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cbi.2012.10.027","article-title":"Biochemical and molecular mechanisms of N-acetyl cysteine and silymarin-mediated protection against maneb- and paraquat-induced hepatotoxicity in rats","volume":"201","author":"Ahmad","year":"2013","journal-title":"Chem. Biol. Interact"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0205","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cbi.2015.02.012","article-title":"The manganese-salen compound EUK-134 and N-acetyl cysteine rescue from zinc- and paraquat-induced toxicity in rat polymorphonuclear leukocytes","volume":"231","author":"Kumar","year":"2015","journal-title":"Chem. Biol. Interact"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0210","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3109\/10715762.2013.806797","article-title":"Mitochondrial susceptibility in a model of paraquat neurotoxicity","volume":"47","author":"Czerniczyniec","year":"2013","journal-title":"Free Radic. Res"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0215","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1165\/ajrcmb.11.1.8018341","article-title":"Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol","volume":"11","author":"Stolk","year":"1994","journal-title":"Am. J. Respir. Cell Mol. Biol"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0220","first-page":"1227","article-title":"Minocycline, levodopa and MnTMPyP induced changes in the mitochondrial proteome profile of MPTP and maneb and paraquat mice models of Parkinson's disease","volume":"2013","author":"Dixit","year":"1832","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.pestbp.2015.03.007_bib0225","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s12035-012-8291-8","article-title":"Rodent models and contemporary molecular techniques: notable feat yet incomplete explanations of Parkinson's disease pathogenesis","volume":"46","author":"Yadav","year":"2012","journal-title":"Mol. Neurobiol"}],"container-title":["Pesticide Biochemistry and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048357515000619?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048357515000619?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T22:56:41Z","timestamp":1747868201000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048357515000619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":44,"alternative-id":["S0048357515000619"],"URL":"https:\/\/doi.org\/10.1016\/j.pestbp.2015.03.007","relation":{},"ISSN":["0048-3575"],"issn-type":[{"value":"0048-3575","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NADPH oxidase mediated maneb- and paraquat-induced oxidative stress in rat polymorphs: Crosstalk with mitochondrial dysfunction","name":"articletitle","label":"Article Title"},{"value":"Pesticide Biochemistry and Physiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pestbp.2015.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}