{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:41:39Z","timestamp":1791686499703,"version":"4.3.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002365","name":"China Agricultural University","doi-asserted-by":"publisher","award":["2016YFD0200202"],"award-info":[{"award-number":["2016YFD0200202"]}],"id":[{"id":"10.13039\/501100002365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pesticide Biochemistry and Physiology"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.pestbp.2021.104983","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T21:06:27Z","timestamp":1636405587000},"page":"104983","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Prothioconazole and prothioconazole-desthio induced different hepatotoxicities via interfering with glycolipid metabolism in mice"],"prefix":"10.1016","volume":"180","author":[{"given":"Sinuo","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiran","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinling","family":"Diao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pestbp.2021.104983_bb0005","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1021\/acs.chemrestox.6b00303","article-title":"Pesticide chemical research in toxicology: lessons from nature","volume":"30","author":"Casida","year":"2017","journal-title":"Chem. Res. Toxicol."},{"issue":"6","key":"10.1016\/j.pestbp.2021.104983_bb0010","first-page":"58","article-title":"A review of research progress in the development of prothioconazole","volume":"47","author":"Cheng","year":"2018","journal-title":"Shandong Chemical Industry"},{"key":"10.1016\/j.pestbp.2021.104983_bb0015","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/MOL.0b013e3282ff5e55","article-title":"Hepatic triglyceride synthesis and nonalcoholic fatty liver disease","volume":"19","author":"Choi","year":"2008","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.pestbp.2021.104983_bb0020","doi-asserted-by":"crossref","first-page":"6458","DOI":"10.1021\/acs.jafc.8b06788","article-title":"Dissipation of prothioconazole and its metabolite prothioconazole-desthio in rice fields and risk assessment of its dietary intake","volume":"67","author":"Dong","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.pestbp.2021.104983_bb0025","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1289\/EHP316","article-title":"Chronic exposure to low doses of dioxin promotes liver fibrosis development in the C57BL\/6J diet-induced obesity mouse model","volume":"125","author":"Duval","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.pestbp.2021.104983_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.109928","article-title":"Multi-level analysis of exposure to triazole fungicides through treated seed ingestion in the red-legged partridge","volume":"189","author":"Fernandez-Vizcaino","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.pestbp.2021.104983_bb0035","first-page":"207","article-title":"Metabolism of prothioconazole (JAU 6476) in animals and plants","volume":"57","author":"Haas","year":"2004","journal-title":"Pflanzenschutz-Nachr. Bayer"},{"key":"10.1016\/j.pestbp.2021.104983_bb0040","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Heiden","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.pestbp.2021.104983_bb0045","first-page":"163","article-title":"Behaviour of prothioconazole (JAU 6476) in the environment","volume":"57","author":"Hellpointner","year":"2004","journal-title":"Pflanzenschutz-Nachrichten Bayer"},{"key":"10.1016\/j.pestbp.2021.104983_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.129147","article-title":"Popping candy-assisted dispersive liquid-liquid microextraction for enantioselective determination of prothioconazole and its chiral metabolite in water, beer, Baijiu, and vinegar samples by HPLC","volume":"348","author":"Jing","year":"2021","journal-title":"Food Chem."},{"key":"10.1016\/j.pestbp.2021.104983_bb0055","doi-asserted-by":"crossref","DOI":"10.3390\/ph13110380","article-title":"Germinated soybean embryo extract ameliorates fatty liver injury in high-fat diet-fed obese mice","volume":"13","author":"Kwon","year":"2020","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.pestbp.2021.104983_bb0060","doi-asserted-by":"crossref","DOI":"10.1007\/s10661-017-5943-1","article-title":"Residue and intake risk assessment of prothioconazole and its metabolite prothioconazole-desthio in wheat field","volume":"189","author":"Lin","year":"2017","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.pestbp.2021.104983_bb0065","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.biocel.2016.01.002","article-title":"Leptin regulates energy metabolism in MCF-7 breast cancer cells","volume":"72","author":"del Mar Blanquer-Rossello","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.pestbp.2021.104983_bb0070","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1172\/JCI200317223","article-title":"Liver-specific disruption of PPAR gamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes","volume":"111","author":"Matsusue","year":"2003","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.pestbp.2021.104983_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113555","article-title":"Different effects of exposure to penconazole and its enantiomers on hepatic glycolipid metabolism of male mice","volume":"257","author":"Meng","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.pestbp.2021.104983_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116215","article-title":"Effects of exposure to prothioconazole and its metabolite prothioconazole-desthio on oxidative stress and metabolic profiles of liver and kidney tissues in male mice","volume":"269","author":"Meng","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.pestbp.2021.104983_bb0085","series-title":"Pesticide Residues in Food - 2008: Report and Evaluation","author":"Organizaton","year":"2009"},{"key":"10.1016\/j.pestbp.2021.104983_bb0090","doi-asserted-by":"crossref","first-page":"100052","DOI":"10.1074\/jbc.RA120.015002","article-title":"PRAP1 is a novel lipid-binding protein that promotes lipid absorption by facilitating MTTP-mediated lipid transport","volume":"296","author":"Peng","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pestbp.2021.104983_bb0095","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1242\/jeb.01961","article-title":"Lactate - a signal coordinating cell and systemic function","volume":"208","author":"Philp","year":"2005","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.pestbp.2021.104983_bb0100","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.5740\/jaoacint.SGE_Raina","article-title":"Determination of azole fungicides in atmospheric samples collected in the Canadian prairies by LC\/MS\/MS","volume":"95","author":"Raina","year":"2012","journal-title":"J. AOAC Int."},{"key":"10.1016\/j.pestbp.2021.104983_bb0105","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.pestbp.2021.104983_bb0110","doi-asserted-by":"crossref","first-page":"G157","DOI":"10.1152\/ajpgi.00004.2017","article-title":"The liver in regulation of iron homeostasis","volume":"313","author":"Rishi","year":"2017","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.pestbp.2021.104983_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167487","article-title":"Levels of selected persistent organic pollutants (PCB, PBDE) and pesticides in honey bee pollen sampled in Poland","volume":"11","author":"Roszko","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.pestbp.2021.104983_bb0120","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.cmet.2017.08.002","article-title":"Nonalcoholic fatty liver disease as a nexus of metabolic and hepatic diseases","volume":"27","author":"Samuel","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.pestbp.2021.104983_bb0125","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8812634","article-title":"Diospyros kaki and Citrus unshiu mixture improves disorders of lipid metabolism in nonalcoholic fatty liver disease","volume":"2020","author":"Shin","year":"2020","journal-title":"Can J Gastroenterol Hepatol."},{"key":"10.1016\/j.pestbp.2021.104983_bb0130","first-page":"269","article-title":"Degradation dynamics and residue analysis of prothioconazole and its metabolite prothioconazole-desthio in wheat and soil by QuEChERS-high performance liquid chromatography-tandem mass spectrometry","volume":"39","author":"Sun","year":"2018","journal-title":"Food Sci."},{"key":"10.1016\/j.pestbp.2021.104983_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.126418","article-title":"Exposure to prothioconazole induces developmental toxicity and cardiovascular effects on zebrafish embryo","volume":"251","author":"Sun","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.pestbp.2021.104983_bb0140","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2021.641890","article-title":"Presence of the weakly pathogenic Fusarium poae in the Fusarium head blight disease complex hampers biocontrol and chemical control of the virulent Fusarium graminearum pathogen","volume":"12","author":"Tan","year":"2021","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.pestbp.2021.104983_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113269","article-title":"Toxicity effects in zebrafish embryos (Danio rerio) induced by prothioconazole","volume":"255","author":"Tian","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.pestbp.2021.104983_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126100","article-title":"New insights into bisphenols induced obesity in zebrafish (Danio rerio): activation of cannabinoid receptor CB1","volume":"418","author":"Tian","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.pestbp.2021.104983_bb0155","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.jnutbio.2013.01.009","article-title":"Polychlorinated biphenyl 153 is a diet-dependent obesogen that worsens nonalcoholic fatty liver disease in male C57BL6\/J mice","volume":"24","author":"Wahlang","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.pestbp.2021.104983_bb0160","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.envint.2019.05.056","article-title":"Bioaccumulation in the gut and liver causes gut barrier dysfunction and hepatic metabolism disorder in mice after exposure to low doses of OBS","volume":"129","author":"Wang","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.pestbp.2021.104983_bb0165","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.chemosphere.2018.07.094","article-title":"Impaired lipid and glucose homeostasis in male mice offspring after combined exposure to low-dose bisphenol A and arsenic during the second half of gestation","volume":"210","author":"Wang","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.pestbp.2021.104983_bb0170","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.envpol.2018.12.053","article-title":"Effects of triphenyl phosphate exposure during fetal development on obesity and metabolic dysfunctions in adult mice: Impaired lipid metabolism and intestinal dysbiosis","volume":"246","author":"Wang","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.pestbp.2021.104983_bb0175","article-title":"PFOS induced lipid metabolism disturbances in BALB\/c mice through inhibition of low density lipoproteins excretion","volume":"4","author":"Wang","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pestbp.2021.104983_bb0180","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.envpol.2019.01.055","article-title":"Comparative toxicokinetics and tissue distribution of prothioconazole and prothioconazole-desthio in Chinese lizards (Eremias argus) and transcriptional responses of metabolic-related genes","volume":"247","author":"Xie","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.pestbp.2021.104983_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113297","article-title":"Gonadal disruption after single dose exposure of prothioconazole and prothioconazole-desthio in male lizards (Eremias argus)","volume":"255","author":"Xie","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.pestbp.2021.104983_bb0190","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.chemosphere.2018.04.101","article-title":"Discrepant effects of alpha-endosulfan, beta-endosulfan, and endosulfan sulfate on oxidative stress and energy metabolism in the livers and kidneys of mice","volume":"205","author":"Yan","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.pestbp.2021.104983_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125661","article-title":"Neonicotinoid insecticides exposure cause amino acid metabolism disorders, lipid accumulation and oxidative stress in ICR mice","volume":"246","author":"Yan","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.pestbp.2021.104983_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116306","article-title":"Exposure to nitenpyram during pregnancy causes colonic mucosal damage and non-alcoholic steatohepatitis in mouse offspring: The role of gut microbiota","volume":"271","author":"Yan","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.pestbp.2021.104983_bb0205","article-title":"Decreased blood glucose and lactate: is a useful indicator of recovery ability in athletes?","volume":"17","author":"Yang","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.pestbp.2021.104983_bb0210","article-title":"Effect of chronic Western diets on non-alcoholic fatty liver of male mice modifying the PPAR-gamma pathway via miR-27b-5p regulation","volume":"22","author":"Zhang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.pestbp.2021.104983_bb0215","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.scitotenv.2018.03.375","article-title":"Enantioselective degradation and transformation of the chiral fungicide prothioconazole and its chiral metabolite in soils","volume":"634","author":"Zhang","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.pestbp.2021.104983_bb0220","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.envpol.2019.04.124","article-title":"Stereoselective endocrine-disrupting effects of the chiral triazole fungicide prothioconazole and its chiral metabolite","volume":"251","author":"Zhang","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.pestbp.2021.104983_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122756","article-title":"Stereoselective uptake and metabolism of prothioconazole caused oxidative stress in zebrafish (Danio rerio)","volume":"396","author":"Zhang","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.pestbp.2021.104983_bb0230","doi-asserted-by":"crossref","first-page":"450","DOI":"10.3109\/00498254.2014.988771","article-title":"Toxicokinetics and tissue distribution of prothioconazole in male adult Sprague-Dawley rats following a single oral administration","volume":"45","author":"Zhou","year":"2015","journal-title":"Xenobiotica"}],"container-title":["Pesticide Biochemistry and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048357521002145?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048357521002145?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T18:00:28Z","timestamp":1758650428000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048357521002145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":46,"alternative-id":["S0048357521002145"],"URL":"https:\/\/doi.org\/10.1016\/j.pestbp.2021.104983","relation":{},"ISSN":["0048-3575"],"issn-type":[{"value":"0048-3575","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prothioconazole and prothioconazole-desthio induced different hepatotoxicities via interfering with glycolipid metabolism in mice","name":"articletitle","label":"Article Title"},{"value":"Pesticide Biochemistry and Physiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pestbp.2021.104983","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104983"}}