{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T02:40:17Z","timestamp":1793155217080,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M741291"],"award-info":[{"award-number":["2023M741291"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32172929"],"award-info":[{"award-number":["32172929"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32402958"],"award-info":[{"award-number":["32402958"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1801100"],"award-info":[{"award-number":["2023YFD1801100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pesticide Biochemistry and Physiology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.pestbp.2025.106463","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T12:02:50Z","timestamp":1747828970000},"page":"106463","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Thiram-driven XBP1 and CHOP pathways orchestrate ER stress and avian tibial dyschondroplasia via metabolic inflammatory axis"],"prefix":"10.1016","volume":"212","author":[{"given":"Shah","family":"Nawaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Farhan","family":"Rahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khodja","family":"Salaheddine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafeez Ur","family":"Rehman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuxian","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md.F.","family":"Kulyar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiakui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pestbp.2025.106463_bb0005","doi-asserted-by":"crossref","DOI":"10.1007\/s10753-019-01139-2","article-title":"Hederacoside-C inhibition of Staphylococcus aureus-induced mastitis via TLR2 & TLR4 and their downstream signaling NF-\u03baB and MAPKs pathways in vivo and in vitro","volume":"43","author":"Akhtar","year":"2020","journal-title":"Inflammation"},{"key":"10.1016\/j.pestbp.2025.106463_bb0010","first-page":"15","article-title":"Role of systemic immune-inflammation index (SII) in assessing clinical efficacy of TNF-\u03b1 inhibitors for rheumatoid arthritis","author":"Bai","year":"2023","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.pestbp.2025.106463_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128808","article-title":"Assessing the effects of Thiram to oxidative stress responses in a freshwater bioindicator cladoceran (Daphnia magna)","volume":"268","author":"Belaid","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.pestbp.2025.106463_bb0020","series-title":"Studia Universitatis \u201cVasile Goldis\u201d Arad Seria Stiintele Vietii","first-page":"29","article-title":"Populational effect of a dithiocarbamate (thiram) fungicide on a freshwater cladocerus Daphnia magna","author":"Belaid","year":"2019"},{"key":"10.1016\/j.pestbp.2025.106463_bb0025","first-page":"1","article-title":"Chemical chaperones reduce ER stress and adipose tissue inflammation in high fat diet-induced mouse model of obesity","volume":"6","author":"Chen","year":"2016","journal-title":"Scientific Reports [Internet]"},{"key":"10.1016\/j.pestbp.2025.106463_bb0030","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/jbmr.321","article-title":"The osteoblast: An insulin target cell controlling glucose homeostasis","volume":"26","author":"Clemens","year":"2011","journal-title":"Journal of Bone and Mineral Research [Internet]"},{"key":"10.1016\/j.pestbp.2025.106463_bb0035","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/s41577-023-00838-0","article-title":"Control of immune cell function by the unfolded protein response","volume":"23","author":"Di Conza","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.pestbp.2025.106463_bb0040","series-title":"Non-alcoholic fatty liver disease and bone tissue metabolism: current findings and future perspectives. mdpi.comOM Drapkina, AY Elkina, AF Sheptulina, AR KiselevInternational Journal of Molecular Sciences, 2023\u2022mdpi.com [Internet]","volume":"2023","author":"Drapkina","year":"2023"},{"key":"10.1016\/j.pestbp.2025.106463_bb0045","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1158\/1541-7786.MCR-21-0702","article-title":"Beyond an unfolded protein response sensor in estrogen-induced apoptosis in endocrine-resistant breast cancer","volume":"20","author":"Fan","year":"2022","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.pestbp.2025.106463_bb0050","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.molmed.2012.06.010","article-title":"ER stress-induced inflammation: Does it aid or impede disease progression?","volume":"18","author":"Garg","year":"2012","journal-title":"Trends Mol Med [Internet]"},{"key":"10.1016\/j.pestbp.2025.106463_bb0055","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.3748\/wjg.15.3516","article-title":"Bone mineral density and disorders of mineral metabolism in chronic liver disease","volume":"15","author":"George","year":"2009","journal-title":"World Journal of Gastroenterology: WJG [Internet]"},{"key":"10.1016\/j.pestbp.2025.106463_bb0060","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nrd3976","article-title":"Targeting the unfolded protein response in disease","volume":"12","author":"Hetz","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.pestbp.2025.106463_bb0070","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.7150\/ijbs.27173","article-title":"The PI3K\/AKT pathway in obesity and type 2 diabetes","volume":"14","author":"Huang","year":"2018","journal-title":"Int J Biol Sci [Internet]."},{"key":"10.1016\/j.pestbp.2025.106463_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115689","article-title":"Baicalin inhibits apoptosis and enhances chondrocyte proliferation in thiram-induced tibial dyschondroplasia in chickens by regulating Bcl-2\/Caspase-9 and Sox-9\/Collagen-II expressions","volume":"268","author":"Iqbal","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.pestbp.2025.106463_bb0080","first-page":"1","article-title":"Gut bacterial metabolites modulate endoplasmic reticulum stress","volume":"22","author":"Ke","year":"2021","journal-title":"Genome Biol [Internet]"},{"key":"10.1016\/j.pestbp.2025.106463_bb0085","first-page":"19","article-title":"Effects of selenium-enriched probiotics on lameness and growth improvement in broiler chickens under heat stress condition","volume":"47","author":"Khan","year":"2021","journal-title":"academia.edu [Internet]"},{"key":"10.1016\/j.pestbp.2025.106463_bb0090","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2011-11-394346","article-title":"Overexpression of TCL1 activates the endoplasmic reticulum stress response: a novel mechanism of leukemic progression in mice","volume":"120","author":"Kriss","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.pestbp.2025.106463_bb0095","first-page":"213","article-title":"Cluster of differentiation 147 (CD147) expression is linked with thiram induced chondrocyte\u2019s apoptosis via Bcl-2\/Bax\/Caspase-3 signalling in tibial growth plate under chlorogenic acid repercussion","author":"Kulyar","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.pestbp.2025.106463_bb0100","first-page":"104","article-title":"Chlorogenic acid suppresses miR-460a in the regulation of Bcl-2, causing interleukin-1\u03b2 reduction in thiram exposed chondrocytes via caspase-3\/caspase-7 pathway","author":"Kulyar","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.pestbp.2025.106463_bb0105","first-page":"22","article-title":"Modulation of apoptosis and Inflammasome activation in chondrocytes: co-regulatory role of Chlorogenic acid","author":"Kulyar","year":"2024","journal-title":"Cell Communication and Signaling."},{"key":"10.1016\/j.pestbp.2025.106463_bb0110","doi-asserted-by":"crossref","DOI":"10.1080\/15548627.2018.1483807","article-title":"Defective autophagy in osteoblasts induces endoplasmic reticulum stress and causes remarkable bone loss","volume":"14","author":"Li","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.pestbp.2025.106463_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127818","article-title":"Metabolomic and transcriptomic investigation of the mechanism involved in enantioselective toxicity of imazamox in Lemna minor","volume":"425","author":"Li","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.pestbp.2025.106463_bb0120","first-page":"65","article-title":"The role of C\/EBP homologous protein (CHOP) in regulating macrophage polarization in RAW264.7 cells","author":"Liu","year":"2021","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.pestbp.2025.106463_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.133928","article-title":"Thiram exposure in environment: a critical review on cytotoxicity","volume":"295","author":"Liu","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.pestbp.2025.106463_bb0130","unstructured":"Liu Y, Mu Y, Wang H, Zhang M, Shi Y, Toxicology GM, et al. Endoplasmic Reticulum Stress Pathway Mediates T-2 Toxin-induced Chondrocyte Apoptosis. Elsevier [Internet]. [cited 2025 Mar 3]; Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0300483X21003115."},{"key":"10.1016\/j.pestbp.2025.106463_bb0135","first-page":"247","article-title":"Thiram induces myocardial oxidative damage and apoptosis in broilers via interfering their cardiac metabolism","author":"Mo","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.pestbp.2025.106463_bb0140","first-page":"444","article-title":"Thiram-induced hyperglycemia causes tibial dyschondroplasia by triggering aberrant ECM remodeling via the gut-pancreas axis in broiler chickens","author":"Mo","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.pestbp.2025.106463_bb0145","first-page":"444","article-title":"Thiram-induced hyperglycemia causes tibial dyschondroplasia by triggering aberrant ECM remodeling via the gut-pancreas axis in broiler chickens","author":"Mo","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.pestbp.2025.106463_bb0150","series-title":"Dithiocarbamate Toxicity - An Appraisal. Pesticides in the Modern World - Effects of Pesticides Exposure","author":"N","year":"2011"},{"issue":"24","key":"10.1016\/j.pestbp.2025.106463_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/ani13243750","article-title":"Homeostatic regulation of pro-angiogenic and anti-angiogenic proteins via hedgehog, notch grid, and ephrin signaling in tibial dyschondroplasia","volume":"13","author":"Nawaz","year":"2023","journal-title":"Animals"},{"key":"10.1016\/j.pestbp.2025.106463_bb0160","first-page":"9","article-title":"XBP1 modulates endoplasmic reticulum and mitochondria crosstalk via regulating NLRP3 in renal ischemia\/reperfusion injury","author":"Ni","year":"2023","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.pestbp.2025.106463_bb0165","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.3382\/ps.2007-00219","article-title":"Thiram-induced changes in the expression of genes relating to vascularization and tibial dyschondroplasia","volume":"86","author":"Rath","year":"2007","journal-title":"Poult. Sci."},{"key":"10.1016\/j.pestbp.2025.106463_bb0170","series-title":"Understanding gut function in poultry: the role of commensals, metabolites, inflammation and dysbiosis in intestinal immune function and dysfunction","first-page":"143","author":"Ricke","year":"2019"},{"key":"10.1016\/j.pestbp.2025.106463_bb0175","author":"ShuCheng"},{"key":"10.1016\/j.pestbp.2025.106463_bb0180","author":"Sj\u00f6"},{"key":"10.1016\/j.pestbp.2025.106463_bb0185","doi-asserted-by":"crossref","first-page":"776","DOI":"10.7150\/ijbs.27063","article-title":"Bone function, dysfunction and its role in diseases including critical illness","volume":"15","author":"Su","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.pestbp.2025.106463_bb0190","first-page":"10","article-title":"Endoplasmic reticulum stress induced by toxic elements\u2014a review of recent developments","volume":"196","author":"SVS","year":"2019","journal-title":"Biological Trace Element Research [Internet]"},{"key":"10.1016\/j.pestbp.2025.106463_bb0195","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1007\/s00198-024-07217-y","article-title":"Metabolic dysfunction\u2013associated fatty liver disease and osteoporosis: the mechanisms and roles of adiposity","volume":"35","author":"Tao","year":"2024","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.pestbp.2025.106463_bb0200","first-page":"14","article-title":"Screening of differentially expressed genes in the growth plate of broiler chickens with Tibial dyschondroplasia by microarray analysis","author":"Tian","year":"2013","journal-title":"BMC Genomics"},{"key":"10.1016\/j.pestbp.2025.106463_bb0205","series-title":"Aquatic Toxicological Aspects of Dithiocarbamates and Related Compounds. II. Effects on Survival, Reproduction and Growth of Daphnia magna","author":"Leeuwen","year":"1985"},{"key":"10.1016\/j.pestbp.2025.106463_bb0210","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1210\/er.2014-1100","article-title":"TLR4 at the Crossroads of Nutrients, Gut Microbiota, and Metabolic Inflammation","volume":"36","author":"Velloso","year":"2015","journal-title":"Endocr Rev [Internet]"},{"key":"10.1016\/j.pestbp.2025.106463_bb0215","doi-asserted-by":"crossref","DOI":"10.1038\/nature06852","article-title":"Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production","volume":"452","author":"Wang","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.pestbp.2025.106463_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2015.09.010","article-title":"A liver-bone endocrine relay by IGFBP1 promotes osteoclastogenesis and mediates FGF21-induced bone resorption","volume":"22","author":"Wang","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.pestbp.2025.106463_bb0225","series-title":"Low-dose thiram exposure elicits dysregulation of the gut microbial ecology in broiler chickens","author":"Wang","year":"2024"},{"key":"10.1016\/j.pestbp.2025.106463_bb0230","author":"Xing"},{"key":"10.1016\/j.pestbp.2025.106463_bb0235","first-page":"9","article-title":"Gut microbiome dysregulation drives bone damage in broiler tibial dyschondroplasia by disrupting glucose homeostasis","author":"Xu","year":"2023","journal-title":"NPJ Biofilms Microbiomes."},{"key":"10.1016\/j.pestbp.2025.106463_bb0240","first-page":"24","article-title":"The effect of miR-140-5p with HDAC4 towards growth and differentiation signaling of chondrocytes in thiram-induced tibial dyschondroplasia","author":"Yao","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.pestbp.2025.106463_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.03.043","article-title":"Identification of differentially expressed MiRNAs profile in a thiram-induced tibial dyschondroplasia","volume":"175","author":"Zhang","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.pestbp.2025.106463_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2024.102340","article-title":"Effects of endoplasmic reticulum stress on chondrocyte apoptosis via the PI3K\/AKT signaling pathway","volume":"87","author":"Zhou","year":"2024","journal-title":"Tissue Cell"}],"container-title":["Pesticide Biochemistry and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048357525001762?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048357525001762?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T03:15:26Z","timestamp":1762226126000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048357525001762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":49,"alternative-id":["S0048357525001762"],"URL":"https:\/\/doi.org\/10.1016\/j.pestbp.2025.106463","relation":{},"ISSN":["0048-3575"],"issn-type":[{"value":"0048-3575","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thiram-driven XBP1 and CHOP pathways orchestrate ER stress and avian tibial dyschondroplasia via metabolic inflammatory axis","name":"articletitle","label":"Article Title"},{"value":"Pesticide Biochemistry and Physiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pestbp.2025.106463","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106463"}}