{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T06:55:04Z","timestamp":1793170504359,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015226","name":"Shengjing Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472242"],"award-info":[{"award-number":["82472242"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pesticide Biochemistry and Physiology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.pestbp.2025.106728","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T08:50:43Z","timestamp":1759308643000},"page":"106728","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"P1","title":["Sesamin exerts protective effects against diquat-induced acute kidney injury by inhibiting oxidative stress, apoptosis and autophagy: A key role for the SIRT5\/FOXO3a signaling pathway"],"prefix":"10.1016","volume":"216","author":[{"given":"Siying","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenning","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.pestbp.2025.106728_bb0005","first-page":"1096","article-title":"A new lignocellulosic material based on Luffa Cylindrica for Nickel (II) adsorption in aqueous solution","volume":"4","author":"Ad","year":"2016","journal-title":"Moroccan J. Chem."},{"issue":"1","key":"10.1016\/j.pestbp.2025.106728_bb0010","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1186\/s12889-020-09939-0","article-title":"The global distribution of acute unintentional pesticide poisoning: estimations based on a systematic review","volume":"20","author":"Boedeker","year":"2020","journal-title":"BMC Public Health"},{"issue":"4","key":"10.1016\/j.pestbp.2025.106728_bb0015","first-page":"391","article-title":"Removal of Nickel (ii) and cadmium (ii) ions from wastewater by palm fibers","volume":"18","author":"Boudaoud","year":"2017","journal-title":"Sci. Study Res.: Chem. Chem. Eng. Biotechnol. Food Indus."},{"key":"10.1016\/j.pestbp.2025.106728_bb0020","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.aquatox.2015.08.004","article-title":"Protective properties of sesamin against fluoride-induced oxidative stress and apoptosis in kidney of carp (Cyprinus carpio) via JNK signaling pathway","volume":"167","author":"Cao","year":"2015","journal-title":"Aquat. Toxicol."},{"issue":"9","key":"10.1016\/j.pestbp.2025.106728_bb0025","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1002\/tox.23853","article-title":"Sesamin suppresses angiotensin-II-enhanced oxidative stress and hypertrophic markers in H9c2 cells","volume":"38","author":"Chang","year":"2023","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.pestbp.2025.106728_bb0030","doi-asserted-by":"crossref","first-page":"4953","DOI":"10.2147\/JIR.S427004","article-title":"Analysis of human microRNA expression profiling during Diquat-induced renal proximal tubular epithelial cell injury","volume":"16","author":"Chen","year":"2023","journal-title":"J. Inflamm. Res."},{"issue":"7","key":"10.1016\/j.pestbp.2025.106728_bb0035","doi-asserted-by":"crossref","first-page":"5485","DOI":"10.1007\/s11033-021-06558-9","article-title":"The role of SIRT5 and p53 proteins in the sensitivity of colon cancer cells to chemotherapeutic agent 5-fluorouracil","volume":"48","author":"Ekremoglu","year":"2021","journal-title":"Mol. Biol. Rep."},{"issue":"1","key":"10.1016\/j.pestbp.2025.106728_bb0040","article-title":"Optical sensing of hydrogen peroxide using starch capped silver nanoparticles, synthesis, optimization and detection in urine","volume":"2","author":"Elgamouz","year":"2020","journal-title":"Sensors Actuat. Reports"},{"key":"10.1016\/j.pestbp.2025.106728_bb0045","series-title":"Toxic Harvest: Exploring Pesticides Impact on Human Health","author":"Elmsellem","year":"2024"},{"issue":"10","key":"10.1016\/j.pestbp.2025.106728_bb0050","first-page":"284","article-title":"Adsorption and corrosion inhibition of mild steel in 0.5 M H2SO4 by a new thiazine derivative 2H-benzo[b][1,4]thiazin-3(4H)-one using experimental and theoretical approaches","volume":"7","author":"Elyoussfi","year":"2015","journal-title":"Der Pharma Chem."},{"issue":"7","key":"10.1016\/j.pestbp.2025.106728_bb0055","doi-asserted-by":"crossref","first-page":"815","DOI":"10.7150\/ijbs.20052","article-title":"FOXO signaling pathways as therapeutic targets in cancer","volume":"13","author":"Farhan","year":"2017","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.pestbp.2025.106728_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120258","article-title":"Inhibition of EZH2 ameliorates hyperoxaluria-induced kidney injury through the JNK\/FoxO3a pathway","volume":"291","author":"Gao","year":"2022","journal-title":"Life Sci."},{"issue":"9","key":"10.1016\/j.pestbp.2025.106728_bb0065","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1158\/0008-5472.CAN-15-2733","article-title":"Mitochondrial Sirtuins in Cancer: emerging roles and therapeutic potential","volume":"76","author":"George","year":"2016","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.pestbp.2025.106728_bb0070","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/SHK.0000000000002392","article-title":"Sirtuin 5 alleviates excessive mitochondrial fission via Desuccinylation of Atpase inhibitory factor 1 in Sepsis-induced acute kidney injury","volume":"62","author":"Li","year":"2024","journal-title":"Shock"},{"issue":"5","key":"10.1016\/j.pestbp.2025.106728_bb0075","first-page":"2245","article-title":"Sesamin protects against renal ischemia reperfusion injury by promoting CD39-adenosine-A2AR signal pathway in mice","volume":"8","author":"Li","year":"2016","journal-title":"Am. J. Transl. Res."},{"issue":"11","key":"10.1016\/j.pestbp.2025.106728_bb0080","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1177\/0960327118765330","article-title":"Human and experimental toxicology of diquat poisoning: Toxicokinetics, mechanisms of toxicity, clinical features, and treatment","volume":"37","author":"Magalhaes","year":"2018","journal-title":"Hum. Exp. Toxicol."},{"issue":"3","key":"10.1016\/j.pestbp.2025.106728_bb0085","doi-asserted-by":"crossref","DOI":"10.2174\/1573399818666220525110925","article-title":"Therapeutic effectiveness of sesame preparations and its bioactive ingredients in management of cardiometabolic syndrome in diabetes mellitus: a systematic review","volume":"19","author":"Mahmoodi","year":"2023","journal-title":"Curr. Diabetes Rev."},{"issue":"18","key":"10.1016\/j.pestbp.2025.106728_bb0090","doi-asserted-by":"crossref","first-page":"5081","DOI":"10.1080\/10408398.2021.1881438","article-title":"Immunomodulatory and anti-inflammatory effects of sesamin: mechanisms of action and future directions","volume":"62","author":"Majdalawieh","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"1","key":"10.1016\/j.pestbp.2025.106728_bb0095","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/s12276-023-00928-y","article-title":"SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis","volume":"55","author":"Mao","year":"2023","journal-title":"Exp. Mol. Med."},{"issue":"4","key":"10.1016\/j.pestbp.2025.106728_bb0100","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3390\/ani13040711","article-title":"Effects of the vitamin D3 on alleviating the oxidative stress induced by Diquat in Wenchang chickens","volume":"13","author":"Nong","year":"2023","journal-title":"Animals"},{"issue":"12","key":"10.1016\/j.pestbp.2025.106728_bb0105","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.tips.2022.09.010","article-title":"FOXO transcription factors as therapeutic targets in human diseases","volume":"43","author":"Orea-Soufi","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.pestbp.2025.106728_bb0110","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1414918","article-title":"Erythrocyte membrane biomimetic EGCG nanoparticles attenuate renal injury induced by diquat through the NF-\u03baB\/NLRP3 inflammasome pathway","volume":"15","author":"Qu","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"30","key":"10.1016\/j.pestbp.2025.106728_bb0115","doi-asserted-by":"crossref","first-page":"9489","DOI":"10.1021\/acs.jafc.2c02470","article-title":"Sesamin ameliorates fine particulate matter (PM(2.5))-induced lung injury via suppression of apoptosis and autophagy in rats","volume":"70","author":"Ren","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.pestbp.2025.106728_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109772","article-title":"Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting Src-mediated NF-kappaB p65 and MAPK signaling pathways in septic AKI mice","volume":"122","author":"Ren","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"8","key":"10.1016\/j.pestbp.2025.106728_bb0125","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1089\/ars.2017.7290","article-title":"The role of Sirtuins in antioxidant and redox signaling","volume":"28","author":"Singh","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.pestbp.2025.106728_bb0130","article-title":"The effects of Sesamin supplementation on obesity, blood pressure, and lipid profile: a systematic review and Meta-analysis of randomized controlled trials","volume":"13","author":"Sun","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"10","key":"10.1016\/j.pestbp.2025.106728_bb0135","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.3390\/antiox10101545","article-title":"Bacillus amyloliquefaciens SC06 induced AKT-FOXO signaling pathway-mediated autophagy to alleviate oxidative stress in IPEC-J2 cells","volume":"10","author":"Tang","year":"2021","journal-title":"Antioxidants (Basel)"},{"issue":"1","key":"10.1016\/j.pestbp.2025.106728_bb0140","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1042\/BJ20140213","article-title":"SIRT3 interactions with FOXO3 acetylation, phosphorylation and ubiquitinylation mediate endothelial cell responses to hypoxia","volume":"464","author":"Tseng","year":"2014","journal-title":"Biochem. J."},{"issue":"12","key":"10.1016\/j.pestbp.2025.106728_bb0145","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1038\/onc.2011.347","article-title":"Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation","volume":"31","author":"Wang","year":"2012","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.pestbp.2025.106728_bb0150","doi-asserted-by":"crossref","first-page":"4931","DOI":"10.3892\/mmr.2016.5867","article-title":"Post-translational modifications of FOXO family proteins (review)","volume":"14","author":"Wang","year":"2016","journal-title":"Mol. Med. Rep."},{"issue":"3","key":"10.1016\/j.pestbp.2025.106728_bb0155","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.tiv.2010.12.009","article-title":"Identification and dissection of the Nrf2 mediated oxidative stress pathway in human renal proximal tubule toxicity","volume":"25","author":"Wilmes","year":"2011","journal-title":"Toxicol. in Vitro"},{"issue":"10","key":"10.1016\/j.pestbp.2025.106728_bb0160","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.3109\/10715762.2012.700709","article-title":"Nrf2 protects against diquat-induced liver and lung injury","volume":"46","author":"Wu","year":"2012","journal-title":"Free Radic. Res."},{"issue":"1","key":"10.1016\/j.pestbp.2025.106728_bb0165","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41392-022-01257-8","article-title":"The sirtuin family in health and disease","volume":"7","author":"Wu","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"23","key":"10.1016\/j.pestbp.2025.106728_bb0170","doi-asserted-by":"crossref","first-page":"4428","DOI":"10.1021\/acschemneuro.1c00468","article-title":"SIRT5 represses neurotrophic pathways and Abeta production in Alzheimer\u2019s disease by targeting autophagy","volume":"12","author":"Wu","year":"2021","journal-title":"ACS Chem. Neurosci."},{"issue":"4","key":"10.1016\/j.pestbp.2025.106728_bb0175","doi-asserted-by":"crossref","DOI":"10.3892\/etm.2022.11201","article-title":"Kidney and lung injury in rats following acute diquat exposure","volume":"23","author":"Wu","year":"2022","journal-title":"Exp. Ther. Med."},{"issue":"2","key":"10.1016\/j.pestbp.2025.106728_bb0180","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2023.2283590","article-title":"Clinical and pathological characteristics of diquat poisoning-related acute kidney injury","volume":"45","author":"Xia","year":"2023","journal-title":"Ren. Fail."},{"issue":"2","key":"10.1016\/j.pestbp.2025.106728_bb0185","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3390\/toxics11020160","article-title":"Melatonin ameliorates Diquat-induced testicular toxicity via reducing oxidative stress, inhibiting apoptosis, and maintaining the integrity of blood-testis barrier in mice","volume":"11","author":"Yang","year":"2023","journal-title":"Toxics"},{"issue":"8","key":"10.1016\/j.pestbp.2025.106728_bb0190","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.3390\/biom12081079","article-title":"Progress in nonalcoholic fatty liver disease: SIRT family regulates mitochondrial biogenesis","volume":"12","author":"Zeng","year":"2022","journal-title":"Biomolecules"},{"issue":"9","key":"10.1016\/j.pestbp.2025.106728_bb0195","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1080\/15563650.2023.2262113","article-title":"Clinical and pathological characteristics of acute kidney injury caused by diquat poisoning","volume":"61","author":"Zeng","year":"2023","journal-title":"Clin. Toxicol. (Phila.)"},{"issue":"5","key":"10.1016\/j.pestbp.2025.106728_bb0200","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3390\/nu8050276","article-title":"Sesamin ameliorates high-fat diet-induced dyslipidemia and kidney injury by reducing oxidative stress","volume":"8","author":"Zhang","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.pestbp.2025.106728_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2022.101609","article-title":"Lethal diquat poisoning manifests as acute central nervous system injury and circulatory failure: a retrospective cohort study of 50 cases","volume":"52","author":"Zhou","year":"2022","journal-title":"EClinicalMedicine"}],"container-title":["Pesticide Biochemistry and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048357525004419?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048357525004419?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T11:54:57Z","timestamp":1773143697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048357525004419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":41,"alternative-id":["S0048357525004419"],"URL":"https:\/\/doi.org\/10.1016\/j.pestbp.2025.106728","relation":{},"ISSN":["0048-3575"],"issn-type":[{"value":"0048-3575","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sesamin exerts protective effects against diquat-induced acute kidney injury by inhibiting oxidative stress, apoptosis and autophagy: A key role for the SIRT5\/FOXO3a signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Pesticide Biochemistry and Physiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pestbp.2025.106728","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106728"}}