{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:04:48Z","timestamp":1790629488488,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32572877"],"award-info":[{"award-number":["32572877"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1400901"],"award-info":[{"award-number":["2023YFD1400901"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pesticide Biochemistry and Physiology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.pestbp.2026.107273","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:34:11Z","timestamp":1784763251000},"page":"107273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Novel A576T or M626I substitutions in the HAMP5 domain of histidine kinase FfOs1 alter ligand-binding pocket to mediate fludioxonil resistance in Fusarium falciforme"],"prefix":"10.1016","volume":"223","author":[{"given":"Bin","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanming","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanqinxue","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiguo","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiushi","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyong","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.pestbp.2026.107273_bb0005","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/j.1365-3059.2009.02230.x","article-title":"Adaptation to pyrrolnitrin in Botrytis cinerea and cost of resistance","volume":"59","author":"Ajouz","year":"2010","journal-title":"Plant Pathol."},{"issue":"8","key":"10.1016\/j.pestbp.2026.107273_bb0010","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1099\/00221287-146-8-1987","article-title":"The ABC transporter AtrB from Aspergillus nidulans mediates resistance to all major classes of fungicides and some natural toxic compounds","volume":"146","author":"Andrade","year":"2000","journal-title":"Microbiology"},{"issue":"8","key":"10.1016\/j.pestbp.2026.107273_bb0015","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1094\/PHYTO-08-12-0207-R","article-title":"Aggressiveness of Fusarium species and impact of root infection on growth and yield of soybeans","volume":"103","author":"Arias","year":"2013","journal-title":"Phytopathology"},{"issue":"4","key":"10.1016\/j.pestbp.2026.107273_bb0020","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s00294-005-0568-2","article-title":"Characterization of mutations in the two-component histidine kinase gene AbNIK1 from Alternaria brassicicola that confer high dicarboximide and phenylpyrrole resistance","volume":"47","author":"Avenot","year":"2005","journal-title":"Curr. Genet."},{"issue":"5","key":"10.1016\/j.pestbp.2026.107273_bb0025","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1091\/mbc.e04-11-0987","article-title":"Specialization of the HOG pathway and its impact on differentiation and virulence of Cryptococcus neoformans","volume":"16","author":"Bahn","year":"2005","journal-title":"Mol. Biol. Cell"},{"issue":"1","key":"10.1016\/j.pestbp.2026.107273_bb0030","doi-asserted-by":"crossref","first-page":"5047","DOI":"10.1038\/s41598-019-41564-9","article-title":"Phenylpyrrole fungicides act on triosephosphate isomerase to induce methylglyoxal stress and alter hybrid histidine kinase activity","volume":"9","author":"Brandhorst","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pestbp.2026.107273_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2025.106505","article-title":"Triple binding pockets of AtSDH: reduced affinity underpins SDHI- resistance in Alternaria tenuissima","volume":"213","author":"Chen","year":"2025","journal-title":"Pestic. Biochem. Physiol."},{"issue":"Pt 1","key":"10.1016\/j.pestbp.2026.107273_bb0040","article-title":"From AI modelling to validation: a 10-day pipeline for potential lead compounds validation","volume":"216","author":"Chen","year":"2026","journal-title":"Pestic. Biochem. Physiol."},{"issue":"2","key":"10.1016\/j.pestbp.2026.107273_bb0045","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s10482-015-0636-7","article-title":"Multilocus phylogeny reveals an association of agriculturally important Fusarium solani species complex (FSSC) 11, and clinically important FSSC 5 and FSSC 3 + 4 with soybean roots in the north central United States","volume":"109","author":"Chitrampalam","year":"2016","journal-title":"Antonie Van Leeuwenhoek"},{"issue":"3","key":"10.1016\/j.pestbp.2026.107273_bb0050","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/ps.1150","article-title":"Impact of fungal drug transporters on fungicide sensitivity, multidrug resistance and virulence","volume":"62","author":"de Waard","year":"2006","journal-title":"Pest Manag. Sci."},{"issue":"4","key":"10.1016\/j.pestbp.2026.107273_bb0055","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1364-3703.2011.00783.x","article-title":"The top 10 fungal pathogens in molecular plant pathology","volume":"13","author":"Dean","year":"2012","journal-title":"Mol. Plant Pathol."},{"issue":"6","key":"10.1016\/j.pestbp.2026.107273_bb0060","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1111\/mpp.12618","article-title":"A review of wheat diseases\u2014a field perspective","volume":"19","author":"Figueroa","year":"2018","journal-title":"Mol. Plant Pathol."},{"issue":"12","key":"10.1016\/j.pestbp.2026.107273_bb0065","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1094\/PHYTO-03-21-0083-R","article-title":"Fusarium root rot complex in soybean: molecular characterization, trichothecene formation, and cross-pathogenicity","volume":"111","author":"Hafez","year":"2021","journal-title":"Phytopathology"},{"issue":"2","key":"10.1016\/j.pestbp.2026.107273_bb0070","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1128\/MMBR.66.2.300-372.2002","article-title":"Osmotic stress signaling and osmoadaptation in yeasts","volume":"66","author":"Hohmann","year":"2002","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.pestbp.2026.107273_bb0075","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.3389\/fmicb.2016.02014","article-title":"Phenylpyrroles: 30 years, two molecules and (nearly) no resistance","volume":"7","author":"Kilani","year":"2016","journal-title":"Front. Microbiol."},{"issue":"21","key":"10.1016\/j.pestbp.2026.107273_bb0080","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1016\/j.febslet.2014.09.012","article-title":"Light-induced switching of HAMP domain conformation and dynamics revealed by time-resolved EPR spectroscopy","volume":"588","author":"Klose","year":"2014","journal-title":"FEBS Lett."},{"issue":"6","key":"10.1016\/j.pestbp.2026.107273_bb0085","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1111\/j.1365-2958.2004.04244.x","article-title":"Fungicide activity through activation of a fungal signalling pathway","volume":"53","author":"Kojima","year":"2004","journal-title":"Mol. Microbiol."},{"issue":"12","key":"10.1016\/j.pestbp.2026.107273_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000696","article-title":"Fungicide-driven evolution and molecular basis of multidrug resistance in field populations of the grey mould fungus Botrytis cinerea","volume":"5","author":"Kretschmer","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pestbp.2026.107273_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2025.106536","article-title":"CiOs1, CiOs4 and CiOs5 modulate temperature-dependent growth and fludioxonil resistance in Calonectria ilicicola, causing soybean red crown rot","volume":"213","author":"Li","year":"2025","journal-title":"Pestic. Biochem. Physiol."},{"issue":"6","key":"10.1016\/j.pestbp.2026.107273_bb0100","doi-asserted-by":"crossref","first-page":"575","DOI":"10.5423\/PPJ.OA.06.2023.0086","article-title":"Distribution and pathogenicity of Fusarium species associated with soybean root rot in Northeast China","volume":"39","author":"Liu","year":"2023","journal-title":"Plant Pathol. J."},{"issue":"1","key":"10.1016\/j.pestbp.2026.107273_bb0105","doi-asserted-by":"crossref","DOI":"10.1093\/ismejo\/wrag080","article-title":"Cross-niche metabolite-microbiome interactions orchestrate systemic soybean resistance to Fusarium root rot","volume":"18","author":"Liu","year":"2024","journal-title":"ISME J."},{"issue":"11","key":"10.1016\/j.pestbp.2026.107273_bb0110","doi-asserted-by":"crossref","first-page":"7651","DOI":"10.1128\/MCB.19.11.7651","article-title":"Differential regulation of the cell wall integrity mitogen-activated protein kinase pathway in budding yeast by the protein tyrosine phosphatases Ptp2 and Ptp3","volume":"19","author":"Mattison","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.pestbp.2026.107273_bb0115","series-title":"Fungicide Resistance in Plant Pathogens","first-page":"77","article-title":"Fitness cost of resistance: impact on management","author":"Mikaberidze","year":"2015"},{"issue":"5","key":"10.1016\/j.pestbp.2026.107273_bb0120","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/ps.302","article-title":"Characterization of mutations in the two-component histidine kinase gene that confer fludioxonil resistance and osmotic sensitivity in the Os-1 mutants of Neurospora crassa","volume":"57","author":"Ochiai","year":"2001","journal-title":"Pest Manag. Sci."},{"issue":"1","key":"10.1016\/j.pestbp.2026.107273_bb0125","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1094\/PHYTO.2002.92.1.75","article-title":"A point mutation in the two-component histidine kinase BcOS-1 gene confers dicarboximide resistance in field isolates of Botrytis cinerea","volume":"92","author":"Oshima","year":"2002","journal-title":"Phytopathology"},{"issue":"9","key":"10.1016\/j.pestbp.2026.107273_bb0130","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1094\/PDIS-11-17-1772-RE","article-title":"Molecular characterization, fitness, and mycotoxin production of Fusarium asiaticum strains resistant to fludioxonil","volume":"102","author":"Qiu","year":"2018","journal-title":"Plant Dis."},{"issue":"1","key":"10.1016\/j.pestbp.2026.107273_bb0135","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.bbrc.2013.07.041","article-title":"The sixth HAMP domain negatively regulates the activity of the group III HHK containing seven HAMP domains","volume":"438","author":"Randhawa","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.pestbp.2026.107273_bb0140","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.gene.2015.12.002","article-title":"Functional dissection of HAMP domains in NIK1 ortholog from pathogenic yeast Candida lusitaniae","volume":"577","author":"Randhawa","year":"2016","journal-title":"Gene"},{"issue":"7","key":"10.1016\/j.pestbp.2026.107273_bb0145","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1094\/PDIS-11-15-1290-RE","article-title":"Molecular and biochemical characterization of laboratory and field mutants of Botrytis cinerea resistant to fludioxonil","volume":"100","author":"Ren","year":"2016","journal-title":"Plant Dis."},{"key":"10.1016\/j.pestbp.2026.107273_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2023.105750","article-title":"A new point mutation (D1158N) in histidine kinase BOs1 confers high-level resistance to fludioxonil in field gray mold disease","volume":"198","author":"Ren","year":"2024","journal-title":"Pestic. Biochem. Physiol."},{"issue":"2","key":"10.1016\/j.pestbp.2026.107273_bb0155","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ijmm.2014.12.007","article-title":"Intraprotein signal transduction by HAMP domains: a balancing act","volume":"305","author":"Schultz","year":"2015","journal-title":"Int. J. Med. Microbiol."},{"issue":"35","key":"10.1016\/j.pestbp.2026.107273_bb0160","doi-asserted-by":"crossref","first-page":"12807","DOI":"10.1021\/acs.jafc.3c02663","article-title":"Overexpression of FgPtp3 is involved in fludioxonil resistance in Fusarium graminearum by inhibiting the phosphorylation of FgHog1","volume":"71","author":"Shi","year":"2023","journal-title":"J. Agric. Food Chem."},{"issue":"49","key":"10.1016\/j.pestbp.2026.107273_bb0165","doi-asserted-by":"crossref","first-page":"25522","DOI":"10.1021\/acs.jafc.4c06858","article-title":"A novel point mutation M460I in histidine kinase FgOs1 confers high resistance to fludioxonil in Fusarium graminearum","volume":"72","author":"Wang","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.pestbp.2026.107273_bb0170","article-title":"Novel point mutations M402V, M541I in the HAMP domain and L915M in the HATPase_c domain of FgOs1 confer differential resistance to fludioxonil in Fusarium graminearum","volume":"306","author":"Wang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"6","key":"10.1016\/j.pestbp.2026.107273_bb0175","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1002\/ps.8002","article-title":"The HOG-pathway related AaOs1 leads to dicarboximide-resistance in field strains of Alternaria alternata and contributes, together with the Aafhk1, to mycotoxin production and virulence","volume":"80","author":"Wei","year":"2024","journal-title":"Pest Manag. Sci."},{"key":"10.1016\/j.pestbp.2026.107273_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2024.105862","article-title":"Resistance mechanism of Phomopsis longicolla to fludioxonil is associated with modifications in PlOS1, PlOS4 and PlOS5","volume":"201","author":"Wei","year":"2024","journal-title":"Pestic. Biochem. Physiol."},{"issue":"1","key":"10.1016\/j.pestbp.2026.107273_bb0185","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/mmi.14258","article-title":"Alternariol as virulence and colonization factor of Alternaria alternata during plant infection","volume":"112","author":"Wenderoth","year":"2019","journal-title":"Mol. Microbiol."},{"issue":"7","key":"10.1016\/j.pestbp.2026.107273_bb0190","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1094\/PDIS-10-22-2317-PDN","article-title":"First report of Fusarium falciforme causing root rot of soybean (Glycine max) in Henan, China","volume":"107","author":"Xu","year":"2023","journal-title":"Plant Dis."},{"issue":"4","key":"10.1016\/j.pestbp.2026.107273_bb0195","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1094\/PHYTO-07-23-0241-R","article-title":"Binding mode and molecular mechanism of the two-component histidine kinase Bos1 of Botrytis cinerea to fludioxonil and iprodione","volume":"114","author":"Yin","year":"2024","journal-title":"Phytopathology"}],"container-title":["Pesticide Biochemistry and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048357526003342?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048357526003342?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:33:26Z","timestamp":1790627606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048357526003342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":39,"alternative-id":["S0048357526003342"],"URL":"https:\/\/doi.org\/10.1016\/j.pestbp.2026.107273","relation":{},"ISSN":["0048-3575"],"issn-type":[{"value":"0048-3575","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel A576T or M626I substitutions in the HAMP5 domain of histidine kinase FfOs1 alter ligand-binding pocket to mediate fludioxonil resistance in Fusarium falciforme","name":"articletitle","label":"Article Title"},{"value":"Pesticide Biochemistry and Physiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pestbp.2026.107273","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107273"}}