{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:04:46Z","timestamp":1790629486530,"version":"4.1.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970465"],"award-info":[{"award-number":["31970465"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008828","name":"Heilongjiang Bayi Agricultural University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008828","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Heilongjiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["YQ2024C042"],"award-info":[{"award-number":["YQ2024C042"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pesticide Biochemistry and Physiology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.pestbp.2026.107316","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:27:23Z","timestamp":1787786843000},"page":"107316","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Ailanthone exerts insecticidal activity as a non-orthosteric 20E antagonist by promoting ecdysone receptor degradation"],"prefix":"10.1016","volume":"223","author":[{"given":"Bingbing","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianyu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pestbp.2026.107316_bb0005","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.ibmb.2011.09.003","article-title":"Drosophila met and Gce are partially redundant in transducing juvenile hormone action","volume":"41","author":"Abdou","year":"2011","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.pestbp.2026.107316_bb0010","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1111\/imb.12867","article-title":"Knockdown of the ecdysone receptor disrupts development and causes mortality in the melon fly, Zeugodacus cucurbitae","volume":"32","author":"Ahmad","year":"2023","journal-title":"Insect Mol. Biol."},{"key":"10.1016\/j.pestbp.2026.107316_bb0015","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0092-8674(00)80624-8","article-title":"Molecular chaperones activate the Drosophila ecdysone receptor, an RXR heterodimer","volume":"101","author":"Arbeitman","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.pestbp.2026.107316_bb0020","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1002\/ptr.6681","article-title":"Anticancer properties and mechanism of action of the quassinoid ailanthone","volume":"34","author":"Bailly","year":"2020","journal-title":"Phytother. Res."},{"key":"10.1016\/j.pestbp.2026.107316_bb0025","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0083-6729(05)73004-1","article-title":"Ligand-binding pocket of the ecdysone receptor","volume":"73","author":"Billas","year":"2005","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.pestbp.2026.107316_bb0030","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nature02112","article-title":"Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor","volume":"426","author":"Billas","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.pestbp.2026.107316_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2025.114808","article-title":"Developmental delay in DCP2(l(3)tb) of Drosophila melanogaster is due to disruption in the regulation of ecdysone signaling","volume":"453","author":"Chaudhary","year":"2025","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.pestbp.2026.107316_bb0040","doi-asserted-by":"crossref","first-page":"11491","DOI":"10.1021\/acs.jafc.3c02275","article-title":"Bruceine D acts as a potential insecticide by antagonizing 20E-EcR\/USP signal transduction","volume":"71","author":"Chen","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.pestbp.2026.107316_bb0045","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1242\/dev.00205","article-title":"EcR isoforms in Drosophila: testing tissue-specific requirements by targeted blockade and rescue","volume":"130","author":"Cherbas","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.pestbp.2026.107316_bb0050","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/sj.cdd.4401692","article-title":"Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting","volume":"12","author":"Ciechanover","year":"2005","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.pestbp.2026.107316_bb0055","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1080\/17429140802503343","article-title":"Bioassay-oriented isolation of an insecticide from Ailanthus altissima","volume":"4","author":"De Feo","year":"2009","journal-title":"J. Plant Interact."},{"key":"10.1016\/j.pestbp.2026.107316_bb0060","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0031-9422(01)00078-4","article-title":"Phytoecdysteroids: biological aspects","volume":"57","author":"Dinan","year":"2001","journal-title":"Phytochemistry"},{"key":"10.1016\/j.pestbp.2026.107316_bb0065","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1042\/bj3270643","article-title":"Cucurbitacins are insect steroid hormone antagonists acting at the ecdysteroid receptor","volume":"327","author":"Dinan","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.pestbp.2026.107316_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23052690","article-title":"Plant secondary metabolites as defense tools against herbivores for sustainable crop protection","volume":"23","author":"Divekar","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.pestbp.2026.107316_bb0075","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.bbamcr.2009.11.012","article-title":"Molecular chaperones, essential partners of steroid hormone receptors for activity and mobility","volume":"1803","author":"Echeverria","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.pestbp.2026.107316_bb0080","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1021\/acs.jafc.2c06243","article-title":"Quassinoids from Picrasma chinensis with insecticidal activity against adults and larvae of Diaphorina citri Kuwayama and neuroprotective effect","volume":"71","author":"Fan","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.pestbp.2026.107316_bb0085","doi-asserted-by":"crossref","first-page":"5592","DOI":"10.1002\/anie.201412126","article-title":"Unprecedented quassinoids with promising biological activity from Harrisonia perforata","volume":"54","author":"Fang","year":"2015","journal-title":"Angew. Chem."},{"key":"10.1016\/j.pestbp.2026.107316_bb0090","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/genetics\/141.3.1025","article-title":"The ecdysone-inducible broad-complex and E74 early genes interact to regulate target gene transcription and Drosophila metamorphosis","volume":"141","author":"Fletcher","year":"1995","journal-title":"Genetics"},{"key":"10.1016\/j.pestbp.2026.107316_bb0095","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1242\/dev.121.5.1411","article-title":"The Drosophila E74 gene is required for the proper stage- and tissue-specific transcription of ecdysone-regulated genes at the onset of metamorphosis","volume":"121","author":"Fletcher","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.pestbp.2026.107316_bb0100","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1534\/genetics.111.132191","article-title":"Isoform-specific regulation of a steroid hormone nuclear receptor by an E3 ubiquitin ligase in Drosophila melanogaster","volume":"189","author":"Gradilla","year":"2011","journal-title":"Genetics"},{"key":"10.1016\/j.pestbp.2026.107316_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0053256","article-title":"MET is required for the maximal action of 20-hydroxyecdysone during Bombyx metamorphosis","volume":"7","author":"Guo","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.pestbp.2026.107316_bb0110","doi-asserted-by":"crossref","first-page":"27874","DOI":"10.1074\/jbc.M114.582825","article-title":"Heat shock protein 83 (Hsp83) facilitates methoprene-tolerant (met) nuclear import to modulate juvenile hormone signaling","volume":"289","author":"He","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pestbp.2026.107316_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2025.106655","article-title":"Mechanistic insights into chlorogenic acid and caffeic acid as novel juvenile hormone antagonists","volume":"215","author":"He","year":"2025","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.pestbp.2026.107316_bb0120","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13122","article-title":"Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer","volume":"7","author":"He","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pestbp.2026.107316_bb0125","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev-ento-120811-153610","article-title":"Ecdysone receptors: from the Ashburner model to structural biology","volume":"58","author":"Hill","year":"2013","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.pestbp.2026.107316_bb0130","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1210\/me.2002-0287","article-title":"Transcription activation by the ecdysone receptor (EcR\/USP): identification of activation functions","volume":"17","author":"Hu","year":"2003","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.pestbp.2026.107316_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120716","article-title":"Ailanthone: a multi-targeting quassinoid from Ailanthus altissima for broad-spectrum cancer therapy - a comprehensive review of mechanisms, pharmacokinetics, and clinical prospects","volume":"355","author":"Huang","year":"2026","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.pestbp.2026.107316_bb0140","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1146\/annurev-ento-011019-025010","article-title":"Botanical insecticides in the twenty-first century\u2014fulfilling their promise?","volume":"65","author":"Isman","year":"2020","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.pestbp.2026.107316_bb0145","doi-asserted-by":"crossref","DOI":"10.1002\/iub.70108","article-title":"Single-sequence deep learning delivers crystal-quality models of covalent K-Ras G12 hotspot complexes","volume":"78","author":"Jung","year":"2026","journal-title":"IUBMB Life"},{"key":"10.1016\/j.pestbp.2026.107316_bb0150","doi-asserted-by":"crossref","first-page":"4083","DOI":"10.1002\/j.1460-2075.1992.tb05501.x","article-title":"Temporal coordination of regulatory gene expression by the steroid hormone ecdysone","volume":"11","author":"Karim","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/j.pestbp.2026.107316_bb0155","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1242\/dev.118.3.977","article-title":"The Drosophila broad-complex plays a key role in controlling ecdysone-regulated gene expression at the onset of metamorphosis","volume":"118","author":"Karim","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.pestbp.2026.107316_bb0160","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S1016-8478(23)13509-6","article-title":"Transcript titers of ecdysteroid receptor components vary between tissues and stages during Drosophila development","volume":"9","author":"Kim","year":"1999","journal-title":"Mol. Cells"},{"key":"10.1016\/j.pestbp.2026.107316_bb0165","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0092-8674(91)90572-G","article-title":"The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily","volume":"67","author":"Koelle","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.pestbp.2026.107316_bb0170","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1515\/bchm3.1992.373.2.573","article-title":"Endocytosis by liver cells during suppression of intralysosomal proteolysis","volume":"373","author":"Korolenko","year":"1992","journal-title":"Biol. Chem. Hoppe Seyler"},{"key":"10.1016\/j.pestbp.2026.107316_bb0175","doi-asserted-by":"crossref","first-page":"25036","DOI":"10.1021\/acs.jafc.6c05674","article-title":"A phloroglucinol from Dryopteris crassirhizoma acts as a 20E antagonist with insecticidal activity by targeting the ecdysone receptor","volume":"74","author":"Li","year":"2026","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.pestbp.2026.107316_bb0180","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1242\/dev.127.13.2897","article-title":"A conditional rescue system reveals essential functions for the ecdysone receptor (EcR) gene during molting and metamorphosis in Drosophila","volume":"127","author":"Li","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.pestbp.2026.107316_bb0185","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1021\/np50051a016","article-title":"Insect antifeedant and growth inhibitory activity of forty-six quassinoids on two species of agricultural pests","volume":"50","author":"Lidert","year":"1987","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.pestbp.2026.107316_bb0190","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0031-9422(01)00061-9","article-title":"Identification and ecdysteroid antagonist activity of three oligostilbenes from the seeds of Carex pendula (Cyperaceae)","volume":"57","author":"Meng","year":"2001","journal-title":"Phytochemistry"},{"key":"10.1016\/j.pestbp.2026.107316_bb0195","doi-asserted-by":"crossref","first-page":"6128","DOI":"10.1111\/j.1742-4658.2009.07347.x","article-title":"Arthropod nuclear receptors and their role in molting","volume":"276","author":"Nakagawa","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.pestbp.2026.107316_bb0200","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/ptr.1336","article-title":"Antiplasmodial activity of extracts and quassinoids isolated from seedlings of Ailanthus altissima (Simaroubaceae)","volume":"17","author":"Okunade","year":"2003","journal-title":"Phytother. Res."},{"key":"10.1016\/j.pestbp.2026.107316_bb0205","first-page":"101","article-title":"Insecticidal activity of compounds from Ailanthus altissima against Spodoptera littoralis larvae","volume":"51","author":"Pavela","year":"2014","journal-title":"Pak. J. Agric. Sci."},{"key":"10.1016\/j.pestbp.2026.107316_bb0210","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.tem.2006.06.003","article-title":"Chaperoning steroid hormone action","volume":"17","author":"Picard","year":"2006","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.pestbp.2026.107316_bb0215","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1177\/153537020322800201","article-title":"Regulation of signaling protein function and trafficking by the hsp90\/hsp70-based chaperone machinery","volume":"228","author":"Pratt","year":"2003","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.pestbp.2026.107316_bb0220","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/(SICI)1520-6327(1997)35:1\/2<211::AID-ARCH19>3.0.CO;2-E","article-title":"Two limonoids from Turraea obtusifolia (Meliaceae), prieurianin and rohitukin, antagonise 20-hydroxyecdysone action in a Drosophila cell line","volume":"35","author":"Sarker","year":"1997","journal-title":"Arch. Insect Biochem. Physiol."},{"key":"10.1016\/j.pestbp.2026.107316_bb0225","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1365-2583.2012.01144.x","article-title":"N- and C-terminal degradation of ecdysteroid receptor isoforms, when transiently expressed in mammalian CHO cells, is regulated by the proteasome and cysteine and threonine proteases","volume":"21","author":"Schauer","year":"2012","journal-title":"Insect Mol. Biol."},{"key":"10.1016\/j.pestbp.2026.107316_bb0230","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1210\/me.2008-0089","article-title":"The intersection of steroid receptors with molecular chaperones: observations and questions","volume":"22","author":"Smith","year":"2008","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.pestbp.2026.107316_bb0235","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1002\/ps.6254","article-title":"Insecticide resistance management and industry: the origins and evolution of the insecticide resistance action committee (IRAC) and the mode of action classification scheme","volume":"77","author":"Sparks","year":"2021","journal-title":"Pest Manag. Sci."},{"key":"10.1016\/j.pestbp.2026.107316_bb0240","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/0092-8674(93)90359-X","article-title":"Drosophila tissues with different metamorphic responses to ecdysone express different ecdysone receptor isoforms","volume":"73","author":"Talbot","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.pestbp.2026.107316_bb0245","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/0168-9525(96)10032-9","article-title":"Flies on steroids\u2014Drosophila metamorphosis and the mechanisms of steroid hormone action","volume":"12","author":"Thummel","year":"1996","journal-title":"Trends Genet."},{"key":"10.1016\/j.pestbp.2026.107316_bb0250","doi-asserted-by":"crossref","first-page":"18473","DOI":"10.1074\/jbc.R800007200","article-title":"The Hsp90 chaperone machinery","volume":"283","author":"Wandinger","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pestbp.2026.107316_bb0255","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.4161\/psb.21663","article-title":"Mechanisms of plant defense against insect herbivores","volume":"7","author":"War","year":"2012","journal-title":"Plant Signal. Behav."},{"key":"10.1016\/j.pestbp.2026.107316_bb0260","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/nrc1716","article-title":"HSP90 and the chaperoning of cancer","volume":"5","author":"Whitesell","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.pestbp.2026.107316_bb0265","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/1744-7917.12777","article-title":"RNA interference targeting ecdysone receptor blocks the larval-pupal transition in Henosepilachna vigintioctopunctata","volume":"28","author":"Wu","year":"2021","journal-title":"Insect Sci."},{"key":"10.1016\/j.pestbp.2026.107316_bb0270","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.jinsphys.2012.01.012","article-title":"Ecdysone receptor controls wing morphogenesis and melanization during rice planthopper metamorphosis","volume":"58","author":"Wu","year":"2012","journal-title":"J. Insect Physiol."},{"key":"10.1016\/j.pestbp.2026.107316_bb0275","doi-asserted-by":"crossref","first-page":"30738","DOI":"10.1021\/acs.jafc.5c07997","article-title":"Rapid discovery of quassinoids with antifeedant activity from Picrasma chinensis employing molecular networking integrated with Mzmine and DeepMass","volume":"73","author":"Xin","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.pestbp.2026.107316_bb0280","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/1744-7917.12662","article-title":"Ecdysone receptor isoforms play distinct roles in larval-pupal-adult transition in Leptinotarsa decemlineata","volume":"27","author":"Xu","year":"2020","journal-title":"Insect Sci."},{"key":"10.1016\/j.pestbp.2026.107316_bb0285","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1146\/annurev-ento-120811-153608","article-title":"Ecdysone control of developmental transitions: lessons from Drosophila research","volume":"58","author":"Yamanaka","year":"2013","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.pestbp.2026.107316_bb0290","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/366476a0","article-title":"Functional ecdysone receptor is the product of EcR and Ultraspiracle genes","volume":"366","author":"Yao","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.pestbp.2026.107316_bb0295","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1083\/jcb.200104079","article-title":"Hsp90: a specialized but essential protein-folding tool","volume":"154","author":"Young","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.pestbp.2026.107316_bb0300","doi-asserted-by":"crossref","first-page":"8226","DOI":"10.1002\/ps.70131","article-title":"C-14 oxygenated quassinoids with control effect against larvae of Diaphorina citri Kuwayama from fruits of Picrasma quassioides","volume":"81","author":"Zhan","year":"2025","journal-title":"Pest Manag. Sci."},{"key":"10.1016\/j.pestbp.2026.107316_bb0305","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1038\/s41401-025-01721-5","article-title":"Benchmarking co-folding methods to predict the structures of covalent protein-ligand complexes","volume":"47","author":"Zhang","year":"2026","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.pestbp.2026.107316_bb0310","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.1016\/j.apsb.2024.04.013","article-title":"Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation","volume":"14","author":"Zhao","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.pestbp.2026.107316_bb0315","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1002\/ps.4817","article-title":"Cucurbitacin B acts as a potential insect growth regulator by antagonizing 20-hydroxyecdysone activity","volume":"74","author":"Zou","year":"2018","journal-title":"Pest Manag. Sci."}],"container-title":["Pesticide Biochemistry and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048357526003779?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048357526003779?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:32:52Z","timestamp":1790627572000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048357526003779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":63,"alternative-id":["S0048357526003779"],"URL":"https:\/\/doi.org\/10.1016\/j.pestbp.2026.107316","relation":{},"ISSN":["0048-3575"],"issn-type":[{"value":"0048-3575","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ailanthone exerts insecticidal activity as a non-orthosteric 20E antagonist by promoting ecdysone receptor degradation","name":"articletitle","label":"Article Title"},{"value":"Pesticide Biochemistry and Physiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pestbp.2026.107316","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107316"}}