{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T09:40:51Z","timestamp":1792748451326,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010038","name":"Earmarked Fund for China Agriculture Research System","doi-asserted-by":"publisher","award":["CARS-26"],"award-info":[{"award-number":["CARS-26"]}],"id":[{"id":"10.13039\/501100010038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pesticide Biochemistry and Physiology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.pestbp.2026.107372","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:10:27Z","timestamp":1791414627000},"page":"107372","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Clustered mutations in CYP51 genes associated with prochloraz resistance in Penicillium italicum"],"prefix":"10.1016","volume":"224","author":[{"given":"Min","family":"Tao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuxing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.pestbp.2026.107372_bb0005","doi-asserted-by":"crossref","first-page":"10654","DOI":"10.1038\/s41467-024-54568-5","article-title":"Elevated mutation rates in multi-azole resistant Aspergillus fumigatus drive rapid evolution of antifungal resistance","volume":"15","author":"Bottery","year":"2024","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.pestbp.2026.107372_bb0010","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.4161\/cc.10.7.15319","article-title":"Damage-induced localized hypermutability","volume":"10","author":"Burch","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.pestbp.2026.107372_bb0015","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev-genet-112414-054714","article-title":"Clusters of multiple mutations: incidence and molecular mechanisms","volume":"49","author":"Chan","year":"2015","journal-title":"Annu. Rev. Genet."},{"issue":"2","key":"10.1016\/j.pestbp.2026.107372_bb0020","first-page":"126","article-title":"Studies on the occurring dynamics of citrus storage disease and the technique of chemical antisepsis and fresh keeping of the fruit","volume":"24","author":"Chen","year":"1997","journal-title":"J. Plant Prot."},{"issue":"20","key":"10.1016\/j.pestbp.2026.107372_bb0025","doi-asserted-by":"crossref","first-page":"8203","DOI":"10.1073\/pnas.0703089104","article-title":"Mutations in clusters and showers","volume":"104","author":"Drake","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.pestbp.2026.107372_bb0030","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.pestbp.2018.08.011","article-title":"Molecular and biological characteristics of laboratory metconazole-resistant mutants in fusarium graminearum","volume":"152","author":"Duan","year":"2018","journal-title":"Pestic. Biochem. Physiol."},{"issue":"1","key":"10.1016\/j.pestbp.2026.107372_bb0035","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.postharvbio.2006.11.008","article-title":"Imazalil resistance linked to a unique insertion sequence in the PdCYP51 promoter region of Penicillium digitatum","volume":"44","author":"Ghosoph","year":"2007","journal-title":"Postharvest Biol. Technol."},{"issue":"6","key":"10.1016\/j.pestbp.2026.107372_bb0040","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/S1097-2765(00)00145-3","article-title":"DNA polymerase zeta introduces multiple mutations when bypassing spontaneous DNA damage in Saccharomyces cerevisiae","volume":"6","author":"Harfe","year":"2000","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.pestbp.2026.107372_bb0045","first-page":"153","article-title":"Sequence comparison of CYP51 genes between imazalil-sensitive and imazalil-resistant strains of penicillium digitatum","volume":"22","author":"Li","year":"2003","journal-title":"Mycosystema"},{"key":"10.1016\/j.pestbp.2026.107372_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.postharvbio.2025.113883","article-title":"CYP51B is involved in the prochloraz resistance of two newly isolated Penicillium italicum strains from citrus fruit","volume":"231","author":"Li","year":"2026","journal-title":"Postharvest Biol. Technol."},{"key":"10.1016\/j.pestbp.2026.107372_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.postharvbio.2016.09.009","article-title":"Effect of cutting styles on quality and antioxidant activity in fresh-cut pitaya fruit","volume":"124","author":"Li","year":"2017","journal-title":"Postharvest Biol. Technol."},{"issue":"12","key":"10.1016\/j.pestbp.2026.107372_bb0060","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25126744","article-title":"Exploring the role of clustered mutations in carcinogenesis and their potential clinical implications in cancer","volume":"25","author":"Li","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.pestbp.2026.107372_bb0065","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2013\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"4","key":"10.1016\/j.pestbp.2026.107372_bb0070","first-page":"1041","article-title":"Molecular mechanisms of prochloraz resistance in Penicillium italicum","volume":"53","author":"Ma","year":"2026","journal-title":"J. Plant Prot."},{"issue":"48","key":"10.1016\/j.pestbp.2026.107372_bb0075","doi-asserted-by":"crossref","first-page":"15046","DOI":"10.1021\/acs.jafc.2c05912","article-title":"Evolution of benzimidazole resistance caused by multiple double mutations of \u03b2-tubulin in Corynespora cassiicola","volume":"70","author":"Mao","year":"2022","journal-title":"J. Agric. Food Chem."},{"issue":"7","key":"10.1016\/j.pestbp.2026.107372_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006733","article-title":"Persistent damaged bases in DNA allow mutagenic break repair in Escherichia coli","volume":"13","author":"Moore","year":"2017","journal-title":"PLoS Genet."},{"issue":"16","key":"10.1016\/j.pestbp.2026.107372_bb0085","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"issue":"1","key":"10.1016\/j.pestbp.2026.107372_bb0090","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1534\/genetics.109.107482","article-title":"Participation of DNA polymerase \u03b6 in replication of undamaged DNA in Saccharomyces cerevisiae","volume":"184","author":"Northam","year":"2010","journal-title":"Genetics"},{"issue":"1","key":"10.1016\/j.pestbp.2026.107372_bb0095","doi-asserted-by":"crossref","DOI":"10.3390\/biom14010132","article-title":"Molecular mechanisms and the significance of synonymous mutations","volume":"14","author":"Oelschlaeger","year":"2024","journal-title":"Biomolecules"},{"issue":"49","key":"10.1016\/j.pestbp.2026.107372_bb0100","doi-asserted-by":"crossref","first-page":"20830","DOI":"10.1073\/pnas.0906681106","article-title":"Use of high throughput sequencing to observe genome dynamics at a single cell level","volume":"106","author":"Parkhomchuk","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"W1","key":"10.1016\/j.pestbp.2026.107372_bb0105","doi-asserted-by":"crossref","first-page":"W463","DOI":"10.1093\/nar\/gkaf361","article-title":"PLIP 2025: introducing protein-protein interactions to the protein-ligand interaction profiler","volume":"53","author":"Schake","year":"2025","journal-title":"Nucleic Acids Res."},{"issue":"43","key":"10.1016\/j.pestbp.2026.107372_bb0110","doi-asserted-by":"crossref","first-page":"27806","DOI":"10.1021\/acs.jafc.5c07618","article-title":"Decoding the Penicillium italicum\u2013citrus interaction: untargeted metabolomics sheds light on a neglected postharvest pathogen","volume":"73","author":"Silva","year":"2025","journal-title":"J. Agric. Food Chem."},{"issue":"9","key":"10.1016\/j.pestbp.2026.107372_bb0115","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/em.21728","article-title":"DNA polymerase zeta generates clustered mutations during bypass of endogenous DNA lesions in Saccharomyces cerevisiae","volume":"53","author":"Stone","year":"2012","journal-title":"Environ. Mol. Mutagen."},{"issue":"W1","key":"10.1016\/j.pestbp.2026.107372_bb0120","doi-asserted-by":"crossref","first-page":"W420","DOI":"10.1093\/nar\/gkac373","article-title":"IBS 2.0: an upgraded illustrator for the visualization of biological sequences","volume":"50","author":"Xie","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.pestbp.2026.107372_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2022.105130","article-title":"Risk and molecular mechanisms for boscalid resistance in Penicillium digitatum","volume":"184","author":"Xu","year":"2022","journal-title":"Pestic. Biochem. Physiol."},{"issue":"11","key":"10.1016\/j.pestbp.2026.107372_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000264","article-title":"Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae","volume":"4","author":"Yang","year":"2008","journal-title":"PLoS Genet."},{"issue":"8","key":"10.1016\/j.pestbp.2026.107372_bb0135","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.dnarep.2010.06.005","article-title":"A single-strand specific lesion drives MMS-induced hypermutability at a double-strand break in yeast","volume":"9","author":"Yang","year":"2010","journal-title":"DNA Repair"},{"issue":"11","key":"10.1016\/j.pestbp.2026.107372_bb0140","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41576-025-00850-1","article-title":"Functional synonymous mutations and their evolutionary consequences","volume":"26","author":"Zhang","year":"2025","journal-title":"Nat. Rev. Genet."},{"issue":"1","key":"10.1016\/j.pestbp.2026.107372_bb0145","article-title":"Transcriptome analysis of fungicide-responsive gene expression profiles in two Penicillium italicum strains with different response to the sterol demethylation inhibitor (DMI) fungicide prochloraz","volume":"21","author":"Zhang","year":"2020","journal-title":"BMC Genomics"},{"issue":"2","key":"10.1016\/j.pestbp.2026.107372_bb0150","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1094\/PDIS-05-20-1128-RE","article-title":"Fungicidal actions and mechanisms of prochloraz to Penicillium digitatum","volume":"105","author":"Zhang","year":"2021","journal-title":"Plant Dis."},{"issue":"6","key":"10.1016\/j.pestbp.2026.107372_bb0155","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1021\/acs.jafc.1c07543","article-title":"Mechanism of Fusarium graminearum resistance to ergosterol biosynthesis inhibitors: G443S substitution of the drug target FgCYP51A","volume":"70","author":"Zhao","year":"2022","journal-title":"J. Agric. Food Chem."},{"issue":"Suppl. II","key":"10.1016\/j.pestbp.2026.107372_bb0160","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1631\/jzus.2006.AS0362","article-title":"Occurrence of imazalil-resistant biotype of Penicillium digitatum in China and the resistant molecular mechanism","volume":"7","author":"Zhu","year":"2006","journal-title":"J. Zhejiang Univ. Sci. A"}],"container-title":["Pesticide Biochemistry and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048357526004335?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048357526004335?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T08:50:01Z","timestamp":1792745401000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048357526004335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":32,"alternative-id":["S0048357526004335"],"URL":"https:\/\/doi.org\/10.1016\/j.pestbp.2026.107372","relation":{},"ISSN":["0048-3575"],"issn-type":[{"value":"0048-3575","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clustered mutations in CYP51 genes associated with prochloraz resistance in Penicillium italicum","name":"articletitle","label":"Article Title"},{"value":"Pesticide Biochemistry and Physiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pestbp.2026.107372","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107372"}}