{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T14:24:52Z","timestamp":1754144692447,"version":"3.41.2"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacological Reports"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.pharep.2013.09.008","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T11:31:11Z","timestamp":1393846271000},"page":"256-263","source":"Crossref","is-referenced-by-count":4,"title":["The endocannabinoid anandamide regulates the peristaltic reflex by reducing neuro-neuronal and neuro-muscular neurotransmission in ascending myenteric reflex pathways in rats"],"prefix":"10.1007","volume":"66","author":[{"given":"Andrei","family":"Sibaev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birol","family":"Yuece","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Dieter","family":"Allescher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Saur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Storr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Kurjak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.pharep.2013.09.008_bib0005","first-page":"81","article-title":"Cannabinoids and gastrointestinal motility: animal and human studies","volume":"12","author":"Aviello","year":"2008","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.pharep.2013.09.008_bib0010","first-page":"R7","article-title":"Inhibition of intestinal motility by anandamide, an endogenous cannabinoid","volume":"340","author":"Calignano","year":"1997","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharep.2013.09.008_bib0015","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/sj.bjp.0704339","article-title":"Inhibitory effect of palmitoylethanolamide on gastrointestinal motility in mice","volume":"134","author":"Capasso","year":"2001","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharep.2013.09.008_bib0020","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1053\/j.gastro.2005.06.018","article-title":"Fatty acid amide hydrolase controls mouse intestinal motility in vivo","volume":"129","author":"Capasso","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pharep.2013.09.008_bib0025","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/sj.bjp.0706824","article-title":"Investigation on the relationship between cannabinoid CB1 and opioid receptors in gastrointestinal motility in mice","volume":"148","author":"Carai","year":"2006","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharep.2013.09.008_bib0030","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/cne.10270","article-title":"Localisation of cannabinoid CB1 receptor immunoreactivity in the guinea pig and rat myenteric plexus","volume":"448","author":"Coutts","year":"2002","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.pharep.2013.09.008_bib0035","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1038\/sj.bjp.0701301","article-title":"Inhibition by cannabinoid receptor agonists of acetylcholine release from the guinea-pig myenteric plexus","volume":"121","author":"Coutts","year":"1997","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharep.2013.09.008_bib0040","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/sj.bjp.0705666","article-title":"The endocannabinoid system: a general view and latest additions","volume":"141","author":"De Petrocellis","year":"2004","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharep.2013.09.008_bib0045","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nrd2553","article-title":"Targeting the endocannabinoid system: to enhance or reduce?","volume":"7","author":"Di Marzo","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.pharep.2013.09.008_bib0050","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.phrs.2009.02.010","article-title":"The endocannabinoid system: its general strategy of action. Tools for its pharmacological manipulation and potential therapeutic exploitation","volume":"60","author":"Di Marzo","year":"2009","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.pharep.2013.09.008_bib0055","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/j.1365-2036.2005.02648.x","article-title":"Review article: endocannabinoids and their receptors in the enteric nervous system","volume":"22","author":"Duncan","year":"2005","journal-title":"Alim Pharmacol Ther"},{"key":"10.1016\/j.pharep.2013.09.008_bib0060","doi-asserted-by":"crossref","first-page":"G78","DOI":"10.1152\/ajpgi.90285.2008","article-title":"Cannabinoid CB2 receptors in the enteric nervous system modulate gastrointestinal contractility in lipopolysaccharide-treated rats","volume":"295","author":"Duncan","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.pharep.2013.09.008_bib0065","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/S0028-3908(99)00056-8","article-title":"Cannabinoid inhibition of guinea-pig intestinal peristalsis via inhibition of excitatory and activation of inhibitory neural pathways","volume":"38","author":"Heinemann","year":"1999","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharep.2013.09.008_bib0070","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1124\/pr.54.2.161","article-title":"International union of pharmacology. XXVII. Classification of cannabinoid receptors","volume":"54","author":"Howlett","year":"2002","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.pharep.2013.09.008_bib0075","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0016-5085(03)00892-8","article-title":"An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice","volume":"125","author":"Izzo","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pharep.2013.09.008_bib0080","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/sj.bjp.0704293","article-title":"Cannabinoid CB1-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation","volume":"134","author":"Izzo","year":"2001","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharep.2013.09.008_bib0085","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s002109900054","article-title":"Inhibitory effect of cannabinoid agonists on gastric emptying in the rat","volume":"360","author":"Izzo","year":"1999","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.pharep.2013.09.008_bib0090","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/sj.bjp.0703116","article-title":"Modulation of peristalsis by cannabinoid CB(1) ligands in the isolated guinea-pig ileum","volume":"129","author":"Izzo","year":"2000","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharep.2013.09.008_bib0095","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1038\/sj.bjp.0703265","article-title":"Central and peripheral cannabinoid modulation of gastrointestinal transit in physiological states or during the diarrhoea induced by croton oil","volume":"129","author":"Izzo","year":"2000","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharep.2013.09.008_bib0100","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pharmthera.2009.12.005","article-title":"Cannabinoids and the gut: new developments and emerging concepts","volume":"126","author":"Izzo","year":"2010","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.pharep.2013.09.008_bib0105","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.npep.2008.08.003","article-title":"Differential stimulatory effects of cannabinoids on VIP release and no synthase activity in synaptosomal fractions from rat ileum","volume":"42","author":"Kurjak","year":"2008","journal-title":"Neuropeptides"},{"key":"10.1016\/j.pharep.2013.09.008_bib0110","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1365-2982.2009.01419.x","article-title":"Involvement of cannabinoid-1 and cannabinoid-2 receptors in septic ileus","volume":"22","author":"Li","year":"2009","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.pharep.2013.09.008_bib0115","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/sj.bjp.0701393","article-title":"Effects of cannabinoid receptor ligands on electrophysiological properties of myenteric neurons of the guinea-pig ileum","volume":"122","author":"Lopez-Redondo","year":"1997","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharep.2013.09.008_bib0120","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/sj.bjp.0704220","article-title":"Differential effects of anandamide on acetylcholine release in the guinea-pig ileum mediated via vanilloid and non-CB1 cannabinoid receptors","volume":"134","author":"Mang","year":"2001","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharep.2013.09.008_bib0125","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1007\/s00109-005-0698-5","article-title":"The endocannabinoid system in the physiology and pathophysiology of the gastrointestinal tract","volume":"83","author":"Massa","year":"2005","journal-title":"J Mol Med"},{"key":"10.1016\/j.pharep.2013.09.008_bib0130","doi-asserted-by":"crossref","DOI":"10.2174\/092986710790980069","article-title":"GPR55: current knowledge and future perspectives of a purported \u201cType-3\u201d cannabinoid receptor","author":"Moriconi","year":"2010","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.pharep.2013.09.008_bib0135","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0014-2999(94)00618-H","article-title":"Effect of phenylmethylsulfonyl fluoride on the potency of anandamide as an inhibitor of electrically evoked contractions in two isolated tissue preparations","volume":"272","author":"Pertwee","year":"1995","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharep.2013.09.008_bib0140","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1111\/j.1476-5381.1996.tb15663.x","article-title":"Further evidence for the presence of cannabinoid CB1 receptors in guinea-pig small intestine","volume":"118","author":"Pertwee","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharep.2013.09.008_bib0145","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1054\/plef.2001.0345","article-title":"Endocannabinoids and the gut","volume":"66","author":"Pinto","year":"2002","journal-title":"Prostaglandins Leuk Essent Fatty Acids"},{"key":"10.1016\/j.pharep.2013.09.008_bib0150","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/sj.bjp.0702363","article-title":"Neural modulation of the cyclic electrical and mechanical activity in the rat colonic circular muscle: putative role of ATP and NO","volume":"126","author":"Pluja","year":"1999","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharep.2013.09.008_bib0155","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/sj.bjp.0705467","article-title":"Anandamide and vanilloid TRPV1 receptors","volume":"140","author":"Ross","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharep.2013.09.008_bib0160","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1586\/ecp.09.62","article-title":"Targeting the endocannabinoid system for gastrointestinal diseases: implicaitons for future therapeutic strategies","volume":"3","author":"Schicho","year":"2010","journal-title":"Expert Rev Clin Pharmacol"},{"key":"10.1016\/j.pharep.2013.09.008_bib0165","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1155\/2011\/953975","article-title":"Alternative targets within the endocannabinoid system for future treatment of gastrointestinal diseases","volume":"25","author":"Schicho","year":"2011","journal-title":"Can J Gastroenterol"},{"key":"10.1016\/j.pharep.2013.09.008_bib0170","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0165-6147(00)01805-8","article-title":"Modulation of transmitter release via presynaptic cannabinoid receptors","volume":"22","author":"Schlicker","year":"2001","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.pharep.2013.09.008_bib0175","doi-asserted-by":"crossref","first-page":"G1325","DOI":"10.1152\/ajpgi.00506.2002","article-title":"Structural differences in the enteric neural network in murine colon: impact on electrophysiology","volume":"285","author":"Sibaev","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.pharep.2013.09.008_bib0180","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1139\/y02-005","article-title":"Effect of cannabinoids on neural transmission in rat gastric fundus","volume":"80","author":"Storr","year":"2002","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.pharep.2013.09.008_bib0185","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s00109-008-0359-6","article-title":"Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors","volume":"86","author":"Storr","year":"2008","journal-title":"J Mol Med"},{"key":"10.1016\/j.pharep.2013.09.008_bib0190","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S0028-3908(03)00028-5","article-title":"Endogenous CCK depresses contractile activity within the ascending myenteric reflex pathway of rat ileum","volume":"44","author":"Storr","year":"2003","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharep.2013.09.008_bib0195","doi-asserted-by":"crossref","first-page":"G110","DOI":"10.1152\/ajpgi.00148.2003","article-title":"Cannabinoid receptor type 1 modulates excitatory and inhibitory neurotransmission in mouse colon","volume":"286","author":"Storr","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.pharep.2013.09.008_bib0200","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF01862644","article-title":"Physiologische Und Pharmakologische Versuche \u00dcber Die D\u00fcnndarmperistaltik","volume":"81","author":"Trendelenburg","year":"1917","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.pharep.2013.09.008_bib0205","first-page":"G237","article-title":"Nonadrenergic, noncholinergic inhibition and rebound excitation in canine colon depend on nitric oxide","volume":"262","author":"Ward","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharep.2013.09.008_bib0210","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/sj.bjp.0707486","article-title":"Cannabinoid CB2 receptors in the gastrointestinal tract: a regulatory system in states of inflammation","volume":"153","author":"Wright","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharep.2013.09.008_bib0215","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2982.2010.01473.x","article-title":"Cannabinoid 1 receptors modulate intestinal sensory and motor function in rat","volume":"22","author":"Yuce","year":"2010","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.pharep.2013.09.008_bib0220","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1053\/j.gastro.2007.05.016","article-title":"ORL-1 receptor mediates the action of nociceptin on ascending myenteric reflex pathways in rats","volume":"133","author":"Yuce","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pharep.2013.09.008_bib0225","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/j.1365-2982.2007.00975.x","article-title":"Cannabinoid type 1 receptor modulates intestinal propulsion by an attenuation of intestinal motor responses within the myenteric part of the peristaltic reflex","volume":"19","author":"Yuece","year":"2007","journal-title":"Neurogastroenterol Motil"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114014000437?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114014000437?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:35:16Z","timestamp":1752611716000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1016\/j.pharep.2013.09.008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S1734114014000437"],"URL":"https:\/\/doi.org\/10.1016\/j.pharep.2013.09.008","relation":{},"ISSN":["1734-1140"],"issn-type":[{"type":"print","value":"1734-1140"}],"subject":[],"published":{"date-parts":[[2014,4]]}}}