{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:53:52Z","timestamp":1773212032777,"version":"3.50.1"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacological Reports"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.pharep.2014.02.004","type":"journal-article","created":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T20:15:16Z","timestamp":1393704916000},"page":"264-272","source":"Crossref","is-referenced-by-count":23,"title":["Beneficial role of tamoxifen in experimentally induced cardiac hypertrophy"],"prefix":"10.1007","volume":"66","author":[{"given":"Bhoomika M.","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishal J.","family":"Desai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"10.1016\/j.pharep.2014.02.004_bib0005","first-page":"534","article-title":"Left ventricular hypertrophy and heart failure in women","volume":"20","author":"Agabiti-Rosei","year":"2002","journal-title":"J Hypertens Suppl"},{"key":"10.1016\/j.pharep.2014.02.004_bib0010","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0008-6363(01)00526-0","article-title":"Estrogenic hormone action in the heart, regulatory network and function","volume":"53","author":"Babiker","year":"2002","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pharep.2014.02.004_bib0015","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1023\/A:1021106232511","article-title":"Alterations in protein kinase C isoenzyme expression and autophosphorylation during the progression of pressure overload-induced left ventricular hypertrophy","volume":"242","author":"Bayer","year":"2003","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.pharep.2014.02.004_bib0020","first-page":"882","article-title":"Reduced glutathione estimation","volume":"61","author":"Beutler","year":"1963","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.pharep.2014.02.004_bib0025","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1046\/j.1538-7836.2003.00392.x","article-title":"Effect of tamoxifen at low dose on ultrasensitivity C-reactive protein in healthy women","volume":"1","author":"Bonanni","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.pharep.2014.02.004_bib0030","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0008-6363(02)00511-4","article-title":"Differential regulation of cardiac protein kinase C isozyme expression after aortic banding in rat","volume":"56","author":"Braun","year":"2002","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pharep.2014.02.004_bib0035","doi-asserted-by":"crossref","first-page":"483","DOI":"10.7326\/0003-4819-151-7-200910060-00009","article-title":"C-reactive protein as a risk factor for coronary heart disease: a systematic review and meta-analyses for the U.S. Preventive Services Task Force","volume":"151","author":"Buckley","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.pharep.2014.02.004_bib0040","doi-asserted-by":"crossref","first-page":"S505","DOI":"10.1016\/0003-4975(95)00842-X","article-title":"Protein kinase C activation in the heart: effects on calcium and contractile proteins","volume":"60","author":"Buenaventura","year":"1995","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.pharep.2014.02.004_bib0045","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.bbrc.2009.06.076","article-title":"Role of protein kinase C delta in angiotensin II induced cardiac fibrosis","volume":"386","author":"Chintalgattu","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.pharep.2014.02.004_bib0050","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/BF02912923","article-title":"Prevention of isoproterenol induced cardiac hypertrophy by Eugenol. An antioxidant","volume":"21","author":"Choudhary","year":"2006","journal-title":"Ind J Clin Biochem"},{"key":"10.1016\/j.pharep.2014.02.004_bib0055","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.yjmcc.2005.07.011","article-title":"Induction of manganese superoxide dismutase (MnSOD) mediates cardioprotective effect of tamoxifen (TAM)","volume":"39","author":"Daosukho","year":"2005","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.pharep.2014.02.004_bib0060","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0735-1097(02)01967-8","article-title":"Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy","volume":"40","author":"Davila-Roman","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.pharep.2014.02.004_bib0065","first-page":"57","article-title":"Experimental hypothyroidism increases content of collagen and glycosaminoglycans in heart","volume":"60","author":"Drobnik","year":"2009","journal-title":"J Physiol Pharmacol"},{"key":"10.1016\/j.pharep.2014.02.004_bib0070","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1161\/01.HYP.0000053446.43894.9F","article-title":"Myocardial PKC \u03b22 and the sensitivity of Na\/K-ATPase to marinobufagenin are reduced by cicletanine in Dahl hypertension","volume":"41","author":"Fedorova","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.pharep.2014.02.004_bib0075","first-page":"1","article-title":"The possible role of PI3K\/Akt pathway in partial abdominal aortic constriction (PAAC) induced pathological cardiac hypertrophy","volume":"1","author":"Gautam","year":"2009","journal-title":"Int J Pharm Recent Res"},{"key":"10.1016\/j.pharep.2014.02.004_bib0080","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/AC.67.2.2154211","article-title":"Beneficial role of spironolactone, telmisartan and their combination on isoproterenol induced cardiac hypertrophy","volume":"67","author":"Goyal","year":"2012","journal-title":"Acta Cardiol"},{"key":"10.1016\/j.pharep.2014.02.004_bib0085","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1177\/0960327112450885","article-title":"Diabetic cardiomyopathy: pathophysiological mechanisms and cardiac dysfunction","volume":"32","author":"Goyal","year":"2013","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.pharep.2014.02.004_bib0090","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s11010-008-9772-y","article-title":"Effect of telmisartan on cardiovascular complications associated with STZ-diabetic rats","volume":"314","author":"Goyal","year":"2008","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.pharep.2014.02.004_bib0095","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S1734-1140(11)70611-9","article-title":"Beneficial role of telmisartan on cardiovascular complications associated with STZ-induced type-2 diabetic rats","volume":"63","author":"Goyal","year":"2011","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.pharep.2014.02.004_bib0100","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000497705","article-title":"Comparative evaluation of spironolactone, atenolol, metoprolol, ramipril and perindopril on diabetes induced cardiovascular complications in type 1 diabetes in rats","volume":"19","author":"Goyal","year":"2011","journal-title":"Int J Diabetes Metab"},{"key":"10.1016\/j.pharep.2014.02.004_bib0105","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1097\/FJC.0b013e3181be75cc","article-title":"Investigation into the cardiac effects of spironolactone in the experimental model of type 1 diabetes","volume":"54","author":"Goyal","year":"2009","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.pharep.2014.02.004_bib0110","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1161\/CIRCULATIONAHA.104.531178","article-title":"Tamoxifen for the prevention of myocardial infarction in humans: preclinical and early clinical evidence","volume":"112","author":"Grainger","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.pharep.2014.02.004_bib0115","doi-asserted-by":"crossref","first-page":"13504","DOI":"10.1074\/jbc.271.23.13504","article-title":"Tamoxifen modulates protein kinase C via oxidative stress in estrogen receptor-negative breast cancer cells","volume":"271","author":"Gundimeda","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharep.2014.02.004_bib0120","doi-asserted-by":"crossref","first-page":"H3768","DOI":"10.1152\/ajpheart.00486.2007","article-title":"Inducible and myocyte-specific inhibition of PKC alpha enhances cardiac contractility and protects against infarction-induced heart failure","volume":"293","author":"Hambleton","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.pharep.2014.02.004_bib0125","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1292\/jvms.71.737","article-title":"Quercetin prevents cardiac hypertrophy induced by pressure overload in rats","volume":"71","author":"Han","year":"2009","journal-title":"J Vet Med Sci"},{"key":"10.1016\/j.pharep.2014.02.004_bib0130","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1210\/jcem.83.5.4753","article-title":"Effect of tamoxifen on serum lipid metabolism","volume":"83","author":"Hozumi","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.pharep.2014.02.004_bib0135","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1056\/NEJM199910213411706","article-title":"Signaling pathway for cardiac hypertrophy and failure","volume":"341","author":"Hunter","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharep.2014.02.004_bib0140","first-page":"151","article-title":"The hemodynamics of isoproterenol-induced cardiac failure in the rat","volume":"8","author":"Iams","year":"1981","journal-title":"Circ Shock"},{"key":"10.1016\/j.pharep.2014.02.004_bib0145","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1080\/01926230500419421","article-title":"Cardiac hypertrophy, a risk factor for QT-prolongation and cardiac sudden death","volume":"34","author":"Kang","year":"2006","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.pharep.2014.02.004_bib0150","doi-asserted-by":"crossref","first-page":"e013","DOI":"10.1621\/nrs.04013","article-title":"Estrogen signaling in the cardiovascular system","volume":"4","author":"Kim","year":"2006","journal-title":"Nucl Recept Signal"},{"key":"10.1016\/j.pharep.2014.02.004_bib0155","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1253\/jcj.55.1149","article-title":"Mechanisms of cardiac hypertrophy and injury \u2013 possible role of protein kinase C activation","volume":"55","author":"Komuro","year":"1991","journal-title":"Jpn Circ J"},{"key":"10.1016\/j.pharep.2014.02.004_bib0160","doi-asserted-by":"crossref","first-page":"H2410","DOI":"10.1152\/ajpheart.2001.281.6.H2410","article-title":"Isoproterenol-induced cardiac hypertrophy: role of circulatory versus cardiac renin\u2013angiotensin system","volume":"281","author":"Leenen","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.pharep.2014.02.004_bib0165","first-page":"196","article-title":"Quantitative analysis of types I and III collagens in the anterior and posterior papillary muscles of the left ventricle of infarcted rats","volume":"24","author":"Lodi","year":"2007","journal-title":"Braz J Morphol Sci"},{"key":"10.1016\/j.pharep.2014.02.004_bib0170","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1136\/bmj.311.7011.977","article-title":"Cardiac and vascular morbidity in women receiving adjuvant tamoxifen for breast cancer in a randomised trial","volume":"311","author":"McDonald","year":"1995","journal-title":"BMJ"},{"key":"10.1016\/j.pharep.2014.02.004_bib0175","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anion autoxidation of epinephrine and a simple method for superoxide dismutase","volume":"247","author":"Misra","year":"1984","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharep.2014.02.004_bib0180","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1291\/hypres.25.153","article-title":"Effects of hormone replacement therapy on left ventricular hypertrophy and growth-promoting factors in hypertensive postmenopausal women","volume":"25","author":"Miya","year":"2002","journal-title":"Hypertens Res"},{"key":"10.1016\/j.pharep.2014.02.004_bib0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1388-9842(00)00085-4","article-title":"Alterations in myocardial creatinine kinase (CK) and lactate dehydrogenase (LDH) isoenzyme-distribution in a model of left ventricular dysfunction","volume":"3","author":"Muders","year":"2001","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.pharep.2014.02.004_bib0190","doi-asserted-by":"crossref","first-page":"F309","DOI":"10.1152\/ajprenal.2000.279.2.F309","article-title":"Selective estrogen receptor modulators suppress mesangial cell collagen synthesis","volume":"279","author":"Neugarten","year":"2000","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.pharep.2014.02.004_bib0195","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay of lipid peroxides in animal tissues thiobarbituric acid reaction","volume":"95","author":"Okhawa","year":"1979","journal-title":"Anal Biochem"},{"key":"10.1016\/j.pharep.2014.02.004_bib0200","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.yjmcc.2008.08.009","article-title":"Mast cells and \u025bPKC, a role in cardiac remodeling in hypertension-induced heart failure","volume":"45","author":"Palaniyandi","year":"2008","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.pharep.2014.02.004_bib0205","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1177\/0960327112446817","article-title":"Perindopril protects against streptozotocin induced hyperglycemic myocardial damage\/alterations","volume":"31","author":"Patel","year":"2012","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.pharep.2014.02.004_bib0210","doi-asserted-by":"crossref","DOI":"10.3109\/10641963.2013.827699","article-title":"Type 2 diabetes induced cardiovascular complications: comparative evaluation of spironolactone, atenolol, metoprolol, ramipril and perindopril","author":"Patel","year":"2013","journal-title":"Clin Exp Hypertens"},{"key":"10.1016\/j.pharep.2014.02.004_bib0215","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1055\/s-0033-1345168","article-title":"Effect of spironolactone on cardiovascular complications associated with type-2 diabetes in rats","volume":"121","author":"Patel","year":"2013","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"10.1016\/j.pharep.2014.02.004_bib0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2012.09.034","article-title":"Aldosterone and angiotensin: role in diabetes and cardiovascular diseases","volume":"697","author":"Patel","year":"2012","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharep.2014.02.004_bib0225","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/1479164113485250","article-title":"The choice of antihypertensive agents in diabetes subjects","volume":"10","author":"Patel","year":"2013","journal-title":"Diab Vasc Dis Res"},{"key":"10.1016\/j.pharep.2014.02.004_bib0230","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1161\/01.CIR.0000159262.18512.46","article-title":"Increased mortality and aggravation of heart failure in estrogen receptor-\u03b2 knockout mice after myocardial infarction","volume":"111","author":"Pelzer","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.pharep.2014.02.004_bib0235","doi-asserted-by":"crossref","first-page":"699","DOI":"10.2147\/CIA.S3551","article-title":"Correlation between myocardial enzyme serum levels and markers of inflammation with severity of coronary artery disease and Gensini score: a hospital-based prospective study in Greek patients","volume":"3","author":"Peppes","year":"2008","journal-title":"Clin Interv Aging"},{"key":"10.1016\/j.pharep.2014.02.004_bib0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1472-8206.2012.01051.x","article-title":"Therapeutic implications of small interfering RNA in cardiovascular diseases","volume":"27","author":"Raghunathan","year":"2013","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1016\/j.pharep.2014.02.004_bib0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00714327","article-title":"Role of cardiac renin\u2013angiotensin system in the development of pressure-overload left ventricular hypertrophy in rats with abdominal aortic constriction","volume":"155","author":"Reddy","year":"1996","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.pharep.2014.02.004_bib0250","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1093\/jnci\/85.17.1398","article-title":"Cardiac and thromboembolic morbidity among postmenopausal women with early-stage breast cancer in a randomized trial of adjuvant tamoxifen","volume":"85","author":"Rutqvist","year":"1993","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.pharep.2014.02.004_bib0255","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1161\/01.CIR.97.15.1488","article-title":"Decompensation of pressure-overload hypertrophy in g alpha q-overexpressing mice","volume":"97","author":"Sakata","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.pharep.2014.02.004_bib0260","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2174\/1573402052952834","article-title":"Extracellular matrix remodeling in hypertension","volume":"1","author":"Sasamura","year":"2005","journal-title":"Curr Hypertens Rev"},{"key":"10.1016\/j.pharep.2014.02.004_bib0265","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/S0022-3565(25)13094-2","article-title":"Tamoxifen (estrogen antagonist) inhibits voltage-gated calcium current and contractility in vascular smooth muscle from rats","volume":"277","author":"Song","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pharep.2014.02.004_bib0270","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.cardiores.2004.06.024","article-title":"Synergistic upregulation of low-density lipoprotein receptor activity by tamoxifen and lovastatin","volume":"64","author":"Suarez","year":"2004","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pharep.2014.02.004_bib0275","doi-asserted-by":"crossref","first-page":"F1399","DOI":"10.1152\/ajprenal.00051.2009","article-title":"Oxalate-induced activation of PKC-\u03b1 and -\u03b4 regulates NADPH oxidase-mediated oxidative injury in renal tubular epithelial cells","volume":"297","author":"Thamilselvan","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.pharep.2014.02.004_bib0280","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/1097-0142(19940701)74:1<78::AID-CNCR2820740114>3.0.CO;2-L","article-title":"Effect of tamoxifen on lipid peroxide and antioxidative system in postmenopausal women with breast cancer","volume":"74","author":"Thangaraju","year":"1994","journal-title":"Cancer"},{"key":"10.1016\/j.pharep.2014.02.004_bib0285","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1152\/physiol.00008.2008","article-title":"The Na-K-ATPase and calcium-signaling microdomains","volume":"23","author":"Tian","year":"2008","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.pharep.2014.02.004_bib0290","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1093\/jn\/131.12.3160","article-title":"Linolenic acid restores renal medullary thick ascending limb Na+K+ATPase activity in diabetic rats","volume":"131","author":"Tsimaratos","year":"2001","journal-title":"J Nutr"},{"key":"10.1016\/j.pharep.2014.02.004_bib0295","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1161\/hc3601.095577","article-title":"17\u03b2-Estradiol attenuates the development of pressure-overload hypertrophy","volume":"104","author":"Van Eickels","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.pharep.2014.02.004_bib0300","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1023\/A:1006859220232","article-title":"Effect of tamoxifen on lipids and lipid metabolising marker enzymes in experimental atherosclerosis in Wistar rats","volume":"168","author":"Vinitha","year":"1997","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.pharep.2014.02.004_bib0305","first-page":"44","article-title":"Differences of creatine kinase MB and cardiac troponin I concentrations in normal and diseased human myocardium","volume":"32","author":"Welsh","year":"2002","journal-title":"Ann Clin Lab Sci"},{"key":"10.1016\/j.pharep.2014.02.004_bib0310","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0014-5793(90)81371-T","article-title":"The antioxidant action of tamoxifen and its metabolites: inhibition of lipid peroxidation","volume":"263","author":"Wiseman","year":"1990","journal-title":"FEBS Lett"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114014000449?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114014000449?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:35:23Z","timestamp":1752611723000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1016\/j.pharep.2014.02.004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S1734114014000449"],"URL":"https:\/\/doi.org\/10.1016\/j.pharep.2014.02.004","relation":{},"ISSN":["1734-1140"],"issn-type":[{"value":"1734-1140","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]}}}