{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T11:23:57Z","timestamp":1773746637738,"version":"3.50.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacological Reports"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.pharep.2014.02.015","type":"journal-article","created":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T06:30:36Z","timestamp":1394605836000},"page":"647-652","source":"Crossref","is-referenced-by-count":45,"title":["Protective effect of nimesulide against hepatic ischemia\/reperfusion injury in rats: Effects on oxidant\/antioxidants, DNA mutation and COX-1\/COX-2 levels"],"prefix":"10.1007","volume":"66","author":[{"given":"Ismail","family":"Demiryilmaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1335-6957","authenticated-orcid":false,"given":"Mehmet Ibrahim","family":"Turan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Kisaoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mine","family":"Gulapoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismayil","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halis","family":"Suleyman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"10.1016\/j.pharep.2014.02.015_bib0005","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.transproceed.2006.10.212","article-title":"Antioxidant patterns (superoxide dismutase, glutathione reductase, and glutathione peroxidase) in kidneys from non-heart-beating-donors: experimental study","volume":"39","author":"Aguilar","year":"2007","journal-title":"Transplantation Proceedings"},{"key":"10.1016\/j.pharep.2014.02.015_bib0010","first-page":"2546","article-title":"Increase of a type of oxidative DNA damage, 8-hydroxyguanine, and its repair activity in human leukocytes by cigarette smoking","volume":"56","author":"Asami","year":"1996","journal-title":"Cancer Research"},{"key":"10.1016\/j.pharep.2014.02.015_bib0015","first-page":"867","article-title":"Synthesis and antioxidant and antimicrobial evaluation of novel 4-substituted-1H-1,2,4-triazole derivatives","volume":"36","author":"Baytas","year":"2012","journal-title":"Turkish Journal of Chemistry"},{"key":"10.1016\/j.pharep.2014.02.015_bib0020","first-page":"G799","article-title":"Reoxygenation injury in isolated rat hepatocytes: relation to oxygen free radicals and lipid peroxidation","volume":"266","author":"Caraceni","year":"1994","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.pharep.2014.02.015_bib0025","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1097\/00000542-200106000-00030","article-title":"Pathophysiology, clinical manifestations, and prevention of ischemia\u2013reperfusion injury","volume":"94","author":"Collard","year":"2001","journal-title":"Anesthesiology"},{"key":"10.1016\/j.pharep.2014.02.015_bib0030","doi-asserted-by":"crossref","first-page":"BR475","DOI":"10.12659\/MSM.883591","article-title":"Biochemically and histopathologically comparative review of thiamine's and thiamine pyrophosphate's oxidative stress effects generated with methotrexate in rat liver","volume":"18","author":"Demiryilmaz","year":"2012","journal-title":"Medical Science Monitor: International Medical Journal of Experimental and Clinical Research"},{"key":"10.1016\/j.pharep.2014.02.015_bib0035","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1530\/JOE-12-0568","article-title":"Adiponectin prevents islet ischemia\u2013reperfusion injury through the COX2-TNFalpha-NF-kappaB-dependent signal transduction pathway in mice","volume":"218","author":"Du","year":"2013","journal-title":"Journal of Endocrinology"},{"key":"10.1016\/j.pharep.2014.02.015_bib0040","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3109\/10715768609083148","article-title":"Hydroxyl free radical adduct of deoxyguanosine: sensitive detection and mechanisms of formation","volume":"1","author":"Floyd","year":"1986","journal-title":"Free Radical Research Communications"},{"key":"10.1016\/j.pharep.2014.02.015_bib0045","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S1734-1140(13)70976-9","article-title":"Effects of lipoic acid on spleen oxidative stress after LPS administration","volume":"65","author":"Goraca","year":"2013","journal-title":"Pharmacological Reports"},{"key":"10.1016\/j.pharep.2014.02.015_bib0050","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0887-2333(03)00077-8","article-title":"Vitamin C protects against in vitro cytotoxicity of cypermethrin in rat hepatocytes","volume":"18","author":"Grajeda-Cota","year":"2004","journal-title":"Toxicology In Vitro"},{"key":"10.1016\/j.pharep.2014.02.015_bib0055","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1093\/clinchem\/41.12.1819","article-title":"Lipid peroxidation and antioxidants as biomarkers of tissue damage","volume":"41","author":"Gutteridge","year":"1995","journal-title":"Clinical Chemistry"},{"key":"10.1016\/j.pharep.2014.02.015_bib0060","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.4049\/jimmunol.180.3.1843","article-title":"Cyclooxygenase-2 deficiency enhances Th2 immune responses and impairs neutrophil recruitment in hepatic ischemia\/reperfusion injury","volume":"180","author":"Hamada","year":"2008","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.pharep.2014.02.015_bib0065","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1002\/hep.1840160626","article-title":"Rapid and marked induction of hepatocyte growth factor during liver regeneration after ischemic or crush injury","volume":"16","author":"Hamanoue","year":"1992","journal-title":"Hepatology"},{"key":"10.1016\/j.pharep.2014.02.015_bib0070","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1124\/jpet.300.2.367","article-title":"Cyclooxygenase \u2013 2\u201310 years later","volume":"300","author":"Hinz","year":"2002","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.pharep.2014.02.015_bib0075","first-page":"647","article-title":"The effects of vitamin C and vitamin E on oxidative DNA damage: results from a randomized controlled trial","volume":"9","author":"Huang","year":"2000","journal-title":"Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology"},{"key":"10.1016\/j.pharep.2014.02.015_bib0080","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/cbf.1232","article-title":"Protective effect of caffeic acid phenethyl ester (CAPE) administration on cisplatin-induced oxidative damage to liver in rat","volume":"24","author":"Iraz","year":"2006","journal-title":"Cell Biochemistry and Function"},{"key":"10.1016\/j.pharep.2014.02.015_bib0085","first-page":"1481","article-title":"The impaired balances of oxidant\/antioxidant and COX-1\/COX-2 in ovarian ischemia\u2013reperfusion injury and prevention by nimesulide","volume":"31","author":"Isaoglu","year":"2012","journal-title":"Latin American Journal of Pharmacy"},{"key":"10.1016\/j.pharep.2014.02.015_bib0090","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1097\/00024382-200115020-00006","article-title":"Protective effect of allopurinol on hepatic energy metabolism in ischemic and reperfused rat liver","volume":"15","author":"Jeon","year":"2001","journal-title":"Shock"},{"issue":"Pt 1","key":"10.1016\/j.pharep.2014.02.015_bib0095","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1042\/bj3180021","article-title":"Measurement of oxidized and methylated DNA bases by HPLC with electrochemical detection","volume":"318","author":"Kaur","year":"1996","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.pharep.2014.02.015_bib0100","doi-asserted-by":"crossref","first-page":"47","DOI":"10.5152\/eajm.2013.08","article-title":"Tissue damage and oxidant\/antioxidant balance","volume":"45","author":"Kisaoglu","year":"2013","journal-title":"Eurasian Journal of Medicine"},{"key":"10.1016\/j.pharep.2014.02.015_bib0105","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0301-2115(98)00242-5","article-title":"Glutathione and glutathione-related enzymes in reproduction. A review","volume":"82","author":"Knapen","year":"1999","journal-title":"European Journal of Obstetrics, Gynecology, and Reproductive Biology"},{"key":"10.1016\/j.pharep.2014.02.015_bib0110","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1002\/art.10969","article-title":"Nonsteroidal antiinflammatory drugs and a selective cyclooxygenase 2 inhibitor uncouple mitochondria in intact cells","volume":"48","author":"Krause","year":"2003","journal-title":"Arthritis and Rheumatism"},{"key":"10.1016\/j.pharep.2014.02.015_bib0115","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/S1734-1140(12)70930-1","article-title":"Protective effect of HMG CoA reductase inhibitors against running wheel activity induced fatigue, anxiety like behavior, oxidative stress and mitochondrial dysfunction in mice","volume":"64","author":"Kumar","year":"2012","journal-title":"Pharmacological Reports"},{"key":"10.1016\/j.pharep.2014.02.015_bib0120","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.brainresbull.2013.02.006","article-title":"Age and meloxicam modify the response of the glutamate vesicular transporters (VGLUTs) after transient global cerebral ischemia in the rat brain","volume":"94","author":"Llorente","year":"2013","journal-title":"Brain Research Bulletin"},{"key":"10.1016\/j.pharep.2014.02.015_bib0125","first-page":"285","article-title":"Inh\u0131b\u0131dores select\u0131vos de la c\u0131cloox\u0131genasa-2: Usos potenc\u0131ales en perros","volume":"33","author":"Madr\u0131gal","year":"2002","journal-title":"Veterinaria Mexico Journal"},{"key":"10.1016\/j.pharep.2014.02.015_bib0130","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/carcin\/21.3.361","article-title":"Oxyradicals and DNA damage","volume":"21","author":"Marnett","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.pharep.2014.02.015_bib0135","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1056\/NEJM198501173120305","article-title":"Oxygen-derived free radicals in postischemic tissue injury","volume":"312","author":"McCord","year":"1985","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.pharep.2014.02.015_bib0140","doi-asserted-by":"crossref","first-page":"6500","DOI":"10.1073\/pnas.94.12.6500","article-title":"Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N-methyl-d-aspartic acid-receptors and phospholipase A2","volume":"94","author":"Miettinen","year":"1997","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharep.2014.02.015_bib0145","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/00024382-200014050-00005","article-title":"Mechanisms for blockade of in vivo activator production in the ischemic intestine and multi-organ failure","volume":"14","author":"Mitsuoka","year":"2000","journal-title":"Shock"},{"key":"10.1016\/j.pharep.2014.02.015_bib0150","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0009-3084(87)90052-1","article-title":"Antioxidants in relation to lipid peroxidation","volume":"44","author":"Niki","year":"1987","journal-title":"Chemistry and Physics of Lipids"},{"key":"10.1016\/j.pharep.2014.02.015_bib0155","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.pharep.2014.02.015_bib0160","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.cbi.2010.03.041","article-title":"Adaptation of rat gastric tissue against indomethacin toxicity","volume":"186","author":"Polat","year":"2010","journal-title":"Chemico\u2013Biological Interactions"},{"key":"10.1016\/j.pharep.2014.02.015_bib0165","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0076-6879(84)05035-7","article-title":"Chemistry of lipid peroxidation","volume":"105","author":"Porter","year":"1984","journal-title":"Methods in Enzymology"},{"key":"10.1016\/j.pharep.2014.02.015_bib0170","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","article-title":"Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent","volume":"25","author":"Sedlak","year":"1968","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.pharep.2014.02.015_bib0175","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/0076-6879(94)34073-0","article-title":"[2] Assays of oxidative DNA damage biomarkers 8-oxo-2\u2032-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection","volume":"234","author":"Shigenaga","year":"1994","journal-title":"Methods in Enzymology"},{"key":"10.1016\/j.pharep.2014.02.015_bib0180","doi-asserted-by":"crossref","first-page":"33157","DOI":"10.1074\/jbc.271.52.33157","article-title":"Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2","volume":"271","author":"Smith","year":"1996","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.pharep.2014.02.015_bib0185","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.crvi.2004.05.007","article-title":"Oxidative stress: a theoretical model or a biological reality?","volume":"327","author":"Sorg","year":"2004","journal-title":"Comptes Rendus Biologies"},{"key":"10.1016\/j.pharep.2014.02.015_bib0190","doi-asserted-by":"crossref","first-page":"278","DOI":"10.2174\/092986708783497247","article-title":"Nimesulide is a selective COX-2 inhibitory, atypical non-steroidal anti-inflammatory drug","volume":"15","author":"Suleyman","year":"2008","journal-title":"Current Medicinal Chemistry"},{"key":"10.1016\/j.pharep.2014.02.015_bib0195","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S1734-1140(09)70094-5","article-title":"Reason for the aggravation of diseases caused by inflammation and the ineffectiveness of NSAIDs on these diseases in rainy weather","volume":"61","author":"Suleyman","year":"2009","journal-title":"Pharmacological Reports"},{"key":"10.1016\/j.pharep.2014.02.015_bib0200","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10565-006-0039-7","article-title":"The effects of subchronic methidathion toxicity on rat liver: role of antioxidant vitamins C and E","volume":"22","author":"Sutcu","year":"2006","journal-title":"Cell Biology and Toxicology"},{"key":"10.1016\/j.pharep.2014.02.015_bib0205","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1046\/j.1440-1827.1999.00829.x","article-title":"Reactive oxygen species-induced molecular damage and its application in pathology","volume":"49","author":"Toyokuni","year":"1999","journal-title":"Pathology International"},{"key":"10.1016\/j.pharep.2014.02.015_bib0210","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1651-2227.1998.tb01509.x","article-title":"Arachidonic acid metabolites in CSF in hypoxic-ischaemic encephalopathy of newborn infants","volume":"87","author":"Vilanova","year":"1998","journal-title":"Acta Paediatrica"},{"key":"10.1016\/j.pharep.2014.02.015_bib0215","first-page":"4443","article-title":"In vivo formation of oxidized DNA bases in tumor promoter-treated mouse skin","volume":"51","author":"Wei","year":"1991","journal-title":"Cancer Research"},{"key":"10.1016\/j.pharep.2014.02.015_bib0220","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.ejogrb.2013.07.027","article-title":"Use of thiamine pyrophosphate to prevent infertility developing in rats undergoing unilateral ovariectomy and with ischemia reperfusion induced in the contralateral ovary","volume":"170","author":"Yapca","year":"2013","journal-title":"European Journal of Obstetrics, Gynecology, and Reproductive Biology"},{"key":"10.1016\/j.pharep.2014.02.015_bib0225","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1136\/jcp.54.3.176","article-title":"Antioxidants in health and disease","volume":"54","author":"Young","year":"2001","journal-title":"Journal of Clinical Pathology"},{"key":"10.1016\/j.pharep.2014.02.015_bib0230","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0039-6109(16)45628-8","article-title":"Reperfusion injury","volume":"72","author":"Zimmerman","year":"1992","journal-title":"Surgical Clinics of North America"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114014000784?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114014000784?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:35:24Z","timestamp":1752611724000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1016\/j.pharep.2014.02.015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S1734114014000784"],"URL":"https:\/\/doi.org\/10.1016\/j.pharep.2014.02.015","relation":{},"ISSN":["1734-1140"],"issn-type":[{"value":"1734-1140","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]}}}