{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:28:58Z","timestamp":1788838138335,"version":"build-2803163510"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Reports"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.pharep.2014.03.004","type":"journal-article","created":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T04:45:46Z","timestamp":1396500346000},"page":"653-659","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Involvement of PKA, PKC, CAMK-II and MEK1\/2 in the acute antidepressant-like effect of creatine in mice"],"prefix":"10.1007","volume":"66","author":[{"given":"Mauricio P.","family":"Cunha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josiane","family":"Budni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis L.","family":"Pazini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8666-9471","authenticated-orcid":false,"given":"\u00c1gatha","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia M.","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5292-8455","authenticated-orcid":false,"given":"Mark W.","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo B.","family":"Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L\u00facia S.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"10.1016\/j.pharep.2014.03.004_bib0095","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1176\/appi.ajp.2012.12050720","article-title":"Bioenergetics for depression: something different for depression","volume":"169","author":"Strakowski","year":"2012","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharep.2014.03.004_bib0020","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1177\/0269881112447989","article-title":"Antidepressant-like effect of creatine in mice involves dopaminergic activation","volume":"26","author":"Cunha","year":"2012","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.pharep.2014.03.004_bib0025","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.pnpbp.2013.01.014","article-title":"The activation of \u03b11-adrenoceptors is implicated in the antidepressant-like effect of creatine in the tail suspension test","volume":"44C","author":"Cunha","year":"2013","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pharep.2014.03.004_bib0030","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.brainresbull.2013.01.005","article-title":"Evidence for the involvement of 5-HT1A receptor in the acute antidepressant-like effect of creatine in mice","volume":"95","author":"Cunha","year":"2013","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.pharep.2014.03.004_bib0060","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1176\/appi.ajp.2012.12010009","article-title":"A randomized, double-blind placebo-controlled trial of oral creatine monohydrate augmentation for enhanced response to a selective serotonin reuptake inhibitor in women with major depressive disorder","volume":"169","author":"Lyoo","year":"2012","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharep.2014.03.004_bib0040","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1034\/j.1399-5618.2002.01203.x","article-title":"Antidepressants and neuroplasticity","volume":"4","author":"D'Sa","year":"2002","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.pharep.2014.03.004_bib0010","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.neulet.2005.10.057","article-title":"Involvement of PKA, MAPK\/ERK and CaMKII, but not PKC in the acute antidepressant-like effect of memantine in mice","volume":"395","author":"Almeida","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pharep.2014.03.004_bib0005","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s12035-011-8210-4","article-title":"A role for the PKC signaling system in the pathophysiology and treatment of mood disorders: involvement of a functional imbalance?","volume":"44","author":"Abrial","year":"2011","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.pharep.2014.03.004_bib0075","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1471-4159.1991.tb02599.x","article-title":"Chronic electroconvulsive treatment augments coupling of the GTP-binding protein Gs to the catalytic moiety of adenylyl cyclase in a manner similar to that seen with chronic antidepressant drugs","volume":"56","author":"Ozawa","year":"1991","journal-title":"J Neurochem"},{"key":"10.1016\/j.pharep.2014.03.004_bib0035","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1152\/ajpcell.00162.2007","article-title":"Creatine enhances differentiation of myogenic C2C12 cells by activating both p38 and Akt\/PKB pathways","volume":"293","author":"Deldicque","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.pharep.2014.03.004_bib0085","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1007\/s00726-012-1329-4","article-title":"Involvement of hippocampal CAMKII\/CREB signaling in the spatial memory retention induced by creatine","volume":"43","author":"Souza","year":"2012","journal-title":"Amino Acids"},{"key":"10.1016\/j.pharep.2014.03.004_bib0090","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pharep.2014.03.004_bib0080","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.pbb.2005.12.017","article-title":"Effectiveness of creatine monohydrate on seizures and oxidative damage induced by methylmalonate","volume":"83","author":"Royes","year":"2006","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pharep.2014.03.004_bib0055","doi-asserted-by":"crossref","first-page":"932414","DOI":"10.1155\/2012\/932414","article-title":"Role of AC-cAMP-PKA cascade in antidepressant action of electroacupuncture treatment in rats","volume":"2012","author":"Liu","year":"2012","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.pharep.2014.03.004_bib0100","doi-asserted-by":"crossref","first-page":"541","DOI":"10.2174\/156800705774322120","article-title":"Protein kinase C isozymes: memory therapeutic potential","volume":"4","author":"Sun","year":"2005","journal-title":"Curr Drug Targets CNS Neurol Disord"},{"key":"10.1016\/j.pharep.2014.03.004_bib0065","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1385\/JMN:24:2:207","article-title":"MAP kinase activation by fluoxetine and its relation to gene expression in cultured rat astrocytes","volume":"24","author":"Mercier","year":"2004","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.pharep.2014.03.004_bib0045","doi-asserted-by":"crossref","first-page":"7686","DOI":"10.1073\/pnas.92.17.7686","article-title":"A synthetic inhibitor of the mitogen-activated protein kinase cascade","volume":"92","author":"Dudley","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.pharep.2014.03.004_bib0050","doi-asserted-by":"crossref","first-page":"18623","DOI":"10.1074\/jbc.273.29.18623","article-title":"Identification of a novel inhibitor of mitogen-activated protein kinase kinase","volume":"273","author":"Favata","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharep.2014.03.004_bib0015","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1159\/000322639","article-title":"Coupling of \u03b11-adrenoceptors to ERK1\/2 in the human prostate","volume":"86","author":"Bauer","year":"2011","journal-title":"Urol Int"},{"key":"10.1016\/j.pharep.2014.03.004_bib0070","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1081\/RRS-200029981","article-title":"Dopamine receptor signaling","volume":"24","author":"Neve","year":"2004","journal-title":"J Recept Signal Transduct Res"},{"key":"10.1016\/j.pharep.2014.03.004_bib0105","doi-asserted-by":"crossref","first-page":"11607","DOI":"10.1073\/pnas.96.20.11607","article-title":"D2 dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neurons","volume":"96","author":"Yan","year":"1999","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114014000905?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114014000905?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:35:27Z","timestamp":1752611727000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1016\/j.pharep.2014.03.004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S1734114014000905"],"URL":"https:\/\/doi.org\/10.1016\/j.pharep.2014.03.004","relation":{},"ISSN":["1734-1140"],"issn-type":[{"value":"1734-1140","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Involvement of PKA, PKC, CAMK-II and MEK1\/2 in the acute antidepressant-like effect of creatine in mice","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharep.2014.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.","name":"copyright","label":"Copyright"}]}}