{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T23:10:58Z","timestamp":1768777858072,"version":"3.49.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Reports"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.pharep.2014.05.008","type":"journal-article","created":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T13:45:12Z","timestamp":1402062312000},"page":"885-891","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice"],"prefix":"10.1007","volume":"66","author":[{"given":"Neeraj","family":"Gilhotra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinesh","family":"Dhingra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"10.1016\/j.pharep.2014.05.008_bib0005","first-page":"199","article-title":"The role of stress in neurodegenerative diseases and mental disorders","volume":"23","author":"Esch","year":"2002","journal-title":"Neuroendocrinol Lett"},{"key":"10.1016\/j.pharep.2014.05.008_bib0010","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/sj.npp.1380104","article-title":"Anti-stress action of corticotrophin-releasing factor antagonist on behavioral reactivity to stressors of varying types and intensity","volume":"11","author":"Heinrichs","year":"1994","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharep.2014.05.008_bib0015","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0893-133X(01)00292-5","article-title":"The increase in TNF-\u03b1 levels is implicated in NF-\u03baB activation and inducible nitric oxide synthase expression in brain cortex after immobilization stress","volume":"26","author":"Madrigal","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharep.2014.05.008_bib0020","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1358\/mf.2006.28.2.977840","article-title":"L-NAME prevent anxiety-like and depression-like behavior in rats exposed to restraint stress","volume":"28","author":"Sevgi","year":"2006","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"10.1016\/j.pharep.2014.05.008_bib0025","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.pnpbp.2009.08.012","article-title":"Involvement of NO-cGMP pathway in anti-anxiety effect of aminoguanidine in stressed mice","volume":"33","author":"Gilhotra","year":"2009","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pharep.2014.05.008_bib0030","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.brainres.2010.07.007","article-title":"GABAergic and nitriergic modulation by curcumin for its antianxiety-like activity in mice","volume":"1352","author":"Gilhotra","year":"2010","journal-title":"Brain Res"},{"key":"10.1016\/j.pharep.2014.05.008_bib0035","first-page":"365","article-title":"Differential effects of nitric oxide synthase inhibitors on anxiety in unstressed and stressed mice","volume":"48","author":"Gilhotra","year":"2010","journal-title":"Indian J Exp Biol"},{"key":"10.1016\/j.pharep.2014.05.008_bib0040","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S1734-1140(11)70577-1","article-title":"Thymoquinone produced antianxiety-like effects in mice through modulation of GABA and NO levels","volume":"63","author":"Gilhotra","year":"2011","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.pharep.2014.05.008_bib0045","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1254\/jphs.11026FP","article-title":"Possible underlying influence of p38MAPK and NF-\u03baB in diminished anti-anxiety effect of diazepam in stressed mice","volume":"116","author":"Sharma","year":"2011","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.pharep.2014.05.008_bib0050","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/jb\/mvg066","article-title":"Nitric oxide synthase induction, cGMP elevation, and biopterin synthesis in vascular smooth muscle cells stimulated with interleukin-1beta in hypoxia","volume":"133","author":"Nagao","year":"2003","journal-title":"J Biochem"},{"key":"10.1016\/j.pharep.2014.05.008_bib0055","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s002130050309","article-title":"7-Nitroindazole, a nitric oxide synthase inhibitor, has anxiolytic-like properties in exploratory models of anxiety","volume":"131","author":"Volke","year":"1997","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pharep.2014.05.008_bib0060","doi-asserted-by":"crossref","first-page":"8725","DOI":"10.1523\/JNEUROSCI.2260-05.2005","article-title":"Previous stress facilitates fear memory, attenuates GABAergic inhibition, and increases synaptic plasticity in the rat basolateral amygdala","volume":"25","author":"Manzanares","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharep.2014.05.008_bib0065","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/1099-0461(2000)14:6<329::AID-JBT5>3.0.CO;2-G","article-title":"Effects of piperine on antioxidant pathways in tissues from normal and streptozotocin-induced diabetic rats","volume":"14","author":"Rauscher","year":"2000","journal-title":"J Biochem Mol Toxicol"},{"key":"10.1016\/j.pharep.2014.05.008_bib0070","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1007\/BF00964845","article-title":"Effects of piperine on convulsions and on brain serotonin and catecholamine levels in E1 mice","volume":"10","author":"Mori","year":"1985","journal-title":"Neurochem Res"},{"key":"10.1016\/j.pharep.2014.05.008_bib0075","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.fct.2009.12.009","article-title":"Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer's disease","volume":"48","author":"Chonpathompikunlert","year":"2010","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.pharep.2014.05.008_bib0080","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1248\/cpb.53.832","article-title":"Piperine from the fruits of piper longum with inhibitory effect on monoamine oxidase and antidepressant-like activity","volume":"53","author":"Lee","year":"2005","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.pharep.2014.05.008_bib0085","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1248\/bpb.33.598","article-title":"Neuroprotective effect of piperine on primarily cultured hippocampal neurons","volume":"33","author":"Fu","year":"2010","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.pharep.2014.05.008_bib0090","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1081\/IPH-120024502","article-title":"Effect of piperine on the inhibition of nitric oxide (NO) and TNF-alpha production","volume":"25","author":"Pradeep","year":"2003","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"10.1016\/j.pharep.2014.05.008_bib0095","series-title":"Handbook of experimental pharmacology","author":"Kulkarni","year":"1999"},{"key":"10.1016\/j.pharep.2014.05.008_bib0100","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0091-3057(80)90067-2","article-title":"Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines","volume":"13","author":"Crawley","year":"1980","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pharep.2014.05.008_bib0105","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0165-0270(80)90012-6","article-title":"The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs","volume":"2","author":"File","year":"1980","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.pharep.2014.05.008_bib0110","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [N-15N]-labelled nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Ann Biochem"},{"key":"10.1016\/j.pharep.2014.05.008_bib0115","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1471-4159.1958.tb12604.x","article-title":"The fluorimetric measurement of glutamic decarboxylase and its distribution in brain","volume":"3","author":"Lowe","year":"1958","journal-title":"J Neurochem"},{"key":"10.1016\/j.pharep.2014.05.008_bib0120","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF02702738","article-title":"Effect of restraint stress on rat brain serotonin","volume":"4","author":"Bhattacharya","year":"1982","journal-title":"J Biosci"},{"key":"10.1016\/j.pharep.2014.05.008_bib0125","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/biof.5520310103","article-title":"Mulberry leaves protect rat tissues from immobilization stress-induced inflammation","volume":"31","author":"Lee","year":"2007","journal-title":"Biofactors"},{"key":"10.1016\/j.pharep.2014.05.008_bib0130","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1021\/np900656g","article-title":"HPLC-based activity profiling: discovery of piperine as a positive GABA(A) receptor modulator targeting a benzodiazepine-independent binding site","volume":"73","author":"Zaugg","year":"2010","journal-title":"J Nat Prod"},{"key":"10.1016\/j.pharep.2014.05.008_bib0135","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2174\/1381612053382214","article-title":"History repeats itself: pharmacodynamic trends in the treatment of anxiety disorders","volume":"11","author":"Schwartz","year":"2005","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.pharep.2014.05.008_bib0140","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.coph.2005.11.005","article-title":"Glutamate- and GABA-based CNS therapeutics","volume":"6","author":"Foster","year":"2006","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.pharep.2014.05.008_bib0145","first-page":"494","article-title":"Stress-restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus","volume":"175","author":"Harvey","year":"2004","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pharep.2014.05.008_bib0150","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/0091-3057(88)90228-6","article-title":"The anxiolytic action of benzodiazepines is not present in handling-habituated rats","volume":"31","author":"Boix","year":"1988","journal-title":"Pharmacol Biochem Behav"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114014002047?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114014002047?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:35:32Z","timestamp":1752611732000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1016\/j.pharep.2014.05.008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S1734114014002047"],"URL":"https:\/\/doi.org\/10.1016\/j.pharep.2014.05.008","relation":{},"ISSN":["1734-1140"],"issn-type":[{"value":"1734-1140","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharep.2014.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.","name":"copyright","label":"Copyright"}]}}