{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:18:31Z","timestamp":1780481911766,"version":"3.54.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Science Centre, Krak\u00f3w, Poland","award":["2011\/01\/B\/NZ4\/04859"],"award-info":[{"award-number":["2011\/01\/B\/NZ4\/04859"]}]},{"name":"Institute of Pharmacology, Polish Academy of Sciences, Krak\u00f3w, Poland"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Reports"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.pharep.2014.07.012","type":"journal-article","created":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T11:16:46Z","timestamp":1407410206000},"page":"1122-1126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["The influence of amitriptyline and carbamazepine on levomepromazine metabolism in human liver: An in vitro study"],"prefix":"10.1007","volume":"66","author":[{"given":"Jacek","family":"W\u00f3jcikowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Basi\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Boksa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W\u0142adys\u0142awa A.","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"issue":"Suppl. 9","key":"10.1016\/j.pharep.2014.07.012_bib0005","first-page":"42","article-title":"Combined treatment strategies in psychiatry","volume":"54","author":"Nelson","year":"1993","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pharep.2014.07.012_bib0010","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1185\/030079904X12708","article-title":"Focus on levomepromazine","volume":"20","author":"Green","year":"2004","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.pharep.2014.07.012_bib0015","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1600-0447.1993.tb03391.x","article-title":"Levomepromazine receptor binding profile in human brain \u2013 implications for treatment-resistant schizophrenia","volume":"87","author":"Lal","year":"1993","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.pharep.2014.07.012_bib0020","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/978-3-642-25761-2_4","article-title":"Serotonergic mechanisms as targets for existing and novel antipsychotics","volume":"212","author":"Meltzer","year":"2012","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.pharep.2014.07.012_bib0025","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0014-2999(86)90793-4","article-title":"Phenothiazine drugs metabolites: dopamine D2 receptor \u03b11 and \u03b12-adrenoceptor binding","volume":"125","author":"Hals","year":"1986","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharep.2014.07.012_bib0030","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.bcp.2014.05.005","article-title":"The cytochrome P450-catalyzed metabolism of levomepromazine, a phenothiazine neuroleptic with a wide spectrum of clinical application","volume":"90","author":"W\u00f3jcikowski","year":"2014","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.pharep.2014.07.012_bib0035","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1046\/j.1365-2125.1997.05382.x","article-title":"Cytochromes P450 mediating the N-demethylation of amitriptyline","volume":"43","author":"Ghahramani","year":"1997","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.pharep.2014.07.012_bib0040","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1016\/0006-2952(94)90071-X","article-title":"Human liver carbamazepine metabolism role of CYP3A4 and CYP2C8 in 10,11-epoxide formation","volume":"47","author":"Kerr","year":"1994","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.pharep.2014.07.012_bib0045","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1211\/0022357001777685","article-title":"Different effects of amitriptyline and imipramine on the pharmacokinetics and metabolism of perazine in rats","volume":"52","author":"Daniel","year":"2000","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.pharep.2014.07.012_bib0050","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/sj.bjp.0703540","article-title":"Pharmacokinetics and metabolism of thioridazine during co-administration of tricyclic antidepressants","volume":"131","author":"Daniel","year":"2000","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharep.2014.07.012_bib0055","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0924-977X(99)00006-1","article-title":"The influence of selective serotonin reuptake inhibitors on the plasma and brain pharmacokinetics of the simplest phenothiazine neuroleptic promazine in rat","volume":"9","author":"Daniel","year":"1999","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.pharep.2014.07.012_bib0060","doi-asserted-by":"crossref","first-page":"454","DOI":"10.2165\/00003088-198106060-00003","article-title":"Interaction of chlorpromazine and nortryptyline in patients with schizophrenia","volume":"6","author":"Loga","year":"1981","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.pharep.2014.07.012_bib0065","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1176\/ajp.137.10.1232","article-title":"Neuroleptic effect on desipramine steady-state plasma concentration","volume":"137","author":"Nelson","year":"1980","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharep.2014.07.012_bib0070","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF00433047","article-title":"Interaction between amitriptyline and phenothiazine in man: effect on plasma concentration of amitriptyline and its metabolite nortriptyline and the correlation with clinical response","volume":"65","author":"Vandel","year":"1979","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pharep.2014.07.012_bib0075","first-page":"431","article-title":"Pharmacokinetics of phenothiazine neuroleptics after chronic coadministration of carbamazepine","volume":"50","author":"Daniel","year":"1998","journal-title":"Pol J Pharmacol"},{"key":"10.1016\/j.pharep.2014.07.012_bib0080","doi-asserted-by":"crossref","first-page":"198","DOI":"10.2165\/00003088-199631030-00004","article-title":"Clinically significant pharmacokinetic drug interactions with carbamazepine. An update","volume":"31","author":"Spina","year":"1996","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.pharep.2014.07.012_bib0085","first-page":"601","article-title":"Effect of carbamazepine on the pharmacokinetics of promazine","volume":"48","author":"Syrek","year":"1996","journal-title":"Pol J Pharmacol"},{"key":"10.1016\/j.pharep.2014.07.012_bib0090","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/j.1552-4604.1998.tb04399.x","article-title":"Five distinct human cytochromes mediate amitriptyline N-demethylation in vitro: dominance of CYP 2C19 and 3A4","volume":"38","author":"Venkatakrishnan","year":"1998","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.pharep.2014.07.012_bib0095","first-page":"449","article-title":"Distribution interactions between perazine and antidepressant drugs. In vivo studies","volume":"52","author":"W\u00f3jcikowski","year":"2000","journal-title":"Pol J Pharmacol"},{"key":"10.1016\/j.pharep.2014.07.012_bib0100","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1055\/s-2004-832687","article-title":"The AGNP TDM expert group consensus guidelines: therapeutic drug monitoring in psychiatry","volume":"37","author":"Baumann","year":"2004","journal-title":"Pharmacopsychiatry"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114014002436?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114014002436?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:35:38Z","timestamp":1752611738000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1016\/j.pharep.2014.07.012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S1734114014002436"],"URL":"https:\/\/doi.org\/10.1016\/j.pharep.2014.07.012","relation":{},"ISSN":["1734-1140"],"issn-type":[{"value":"1734-1140","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The influence of amitriptyline and carbamazepine on levomepromazine metabolism in human liver: An in vitro study","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharep.2014.07.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.","name":"copyright","label":"Copyright"}]}}