{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:17:29Z","timestamp":1790421449108,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Reports"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.pharep.2015.05.027","type":"journal-article","created":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T04:55:56Z","timestamp":1434084956000},"page":"80-84","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Stimulation of the metabotropic glutamate (mGlu) 2 receptor attenuates the MK-801-induced increase in the immobility time in the forced swimming test in rats"],"prefix":"10.1007","volume":"68","author":[{"given":"Kazuaki","family":"Kawaura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ichi","family":"Karasawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohiko","family":"Hikichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"issue":"3","key":"10.1016\/j.pharep.2015.05.027_bib0140","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00213-007-0974-x","article-title":"The mGlu2 but not the mGlu3 receptor mediates the actions of the mGluR2\/3 agonist, LY379268, in mouse models predictive of antipsychotic activity","volume":"196","author":"Woolley","year":"2008","journal-title":"Psychopharmacology (Berl)"},{"issue":"1","key":"10.1016\/j.pharep.2015.05.027_bib0145","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1124\/jpet.106.102046","article-title":"Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice","volume":"318","author":"Galici","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"issue":"4","key":"10.1016\/j.pharep.2015.05.027_bib0150","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/npp.2011.274","article-title":"Pharmacological activation of group-II metabotropic glutamate receptors corrects a schizophrenia-like phenotype induced by prenatal stress in mice","volume":"37","author":"Matrisciano","year":"2012","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.pharep.2015.05.027_bib0155","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1254\/jphs.13036FP","article-title":"Stimulation of metabotropic glutamate (mGlu) 2 receptor and blockade of mGlu1 receptor improve social memory impairment elicited by MK-801 in rats","volume":"122","author":"Hikichi","year":"2013","journal-title":"J Pharmacol Sci"},{"issue":"9","key":"10.1016\/j.pharep.2015.05.027_bib0160","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/nm1632","article-title":"Activation of mGlu2\/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial","volume":"13","author":"Patil","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.pharep.2015.05.027_bib0165","series-title":"Addex Therapeutics web site [homepage on the Internet]. Addex reports top-line data from a successful phase 2a clinical study with ADX71149 in schizophrenia patients","year":"2012"},{"key":"10.1016\/j.pharep.2015.05.027_bib0170","series-title":"Eli Lilly web site [homepage on the Internet]. Lilly stops phase III development of pomaglumetad methionil For the treatment of schizophrenia based on efficacy results","year":"2012"},{"issue":"5","key":"10.1016\/j.pharep.2015.05.027_bib0175","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00406-013-0399-y","article-title":"Glutamate modulators as potential therapeutic drugs in schizophrenia and affective disorders","volume":"263","author":"Hashimoto","year":"2013","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"issue":"10","key":"10.1016\/j.pharep.2015.05.027_bib0180","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1176\/ajp.148.10.1301","article-title":"Recent advances in the phencyclidine model of schizophrenia","volume":"148","author":"Javitt","year":"1991","journal-title":"Am J Psychiatry"},{"issue":"3","key":"10.1016\/j.pharep.2015.05.027_bib0185","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3109\/hrp.7.3.125","article-title":"NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies in neuropsychiatric disorders","volume":"7","author":"Krystal","year":"1997","journal-title":"Harv Rev Psychiatry"},{"issue":"1","key":"10.1016\/j.pharep.2015.05.027_bib0190","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0893-133X(94)00131-I","article-title":"Subanesthetic doses of ketamine stimulate psychosis in schizophrenia","volume":"13","author":"Lahti","year":"1995","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharep.2015.05.027_bib0195","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbr.2014.09.046","article-title":"Effects of a glycine transporter-1 inhibitor and d-serine on MK-801-induced immobility in the forced swimming test in rats","volume":"278","author":"Kawaura","year":"2015","journal-title":"Behav Brain Res"},{"issue":"5","key":"10.1016\/j.pharep.2015.05.027_bib0200","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1111\/j.1476-5381.1995.tb15106.x","article-title":"Enhancement of immobility in a forced swimming test by subacute or repeated treatment with phencyclidine: a new model of schizophrenia","volume":"116","author":"Noda","year":"1995","journal-title":"Br J Pharmacol"},{"issue":"2","key":"10.1016\/j.pharep.2015.05.027_bib0205","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00213-011-2567-y","article-title":"Effect of PDE10A inhibitors on MK-801-induced immobility in the forced swim test","volume":"221","author":"Langen","year":"2012","journal-title":"Psychopharmacology (Berl)"},{"issue":"2","key":"10.1016\/j.pharep.2015.05.027_bib0210","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.pnpbp.2012.04.018","article-title":"Ketamine-enhanced immobility in forced swim test: a possible animal model for the negative symptoms of schizophrenia","volume":"38","author":"Chindo","year":"2012","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"3","key":"10.1016\/j.pharep.2015.05.027_bib0215","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/00004714-199406000-00008","article-title":"Clozapine effects on positive and negative symptoms: a six-month trial in treatment-refractory schizophrenics","volume":"14","author":"Lindenmayer","year":"1994","journal-title":"J Clin Psychopharmacol"},{"issue":"1","key":"10.1016\/j.pharep.2015.05.027_bib0220","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/0010-440X(94)90164-3","article-title":"Clozapine's effect on negative symptoms in treatment-refractory schizophrenics","volume":"35","author":"Miller","year":"1994","journal-title":"Compr Psychiatry"},{"issue":"3","key":"10.1016\/j.pharep.2015.05.027_bib0225","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jphs.2015.02.004","article-title":"Antipsychotic profiles of TASP0443294, a novel and orally active positive allosteric modulator of metabotropic glutamate 2 receptor","volume":"127","author":"Hikichi","year":"2015","journal-title":"J Pharmacol Sci"},{"issue":"1","key":"10.1016\/j.pharep.2015.05.027_bib0230","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0022-3565(24)35084-0","article-title":"The metabotropic glutamate 2\/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats","volume":"291","author":"Cartmell","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pharep.2015.05.027_bib0235","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.bbr.2013.08.007","article-title":"The reversal of cognitive, but not negative or positive symptoms of schizophrenia, by the mGlu2\/3 receptor agonist, LY379268, is 5-HT1A dependent","volume":"256","author":"Wiero\u0144ska","year":"2013","journal-title":"Behav Brain Res"},{"issue":"6","key":"10.1016\/j.pharep.2015.05.027_bib0240","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/nprot.2012.044","article-title":"Using the rat forced swim test to assess antidepressant-like activity in rodents","volume":"7","author":"Slattery","year":"2012","journal-title":"Nat Protocols"},{"issue":"3","key":"10.1016\/j.pharep.2015.05.027_bib0245","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0014-2999(78)90414-4","article-title":"\u201cBehavioural despair\u201d in rats and mice: strain differences and the effects of imipramine","volume":"51","author":"Porsolt","year":"1978","journal-title":"Eur J Pharmacol"},{"issue":"7183","key":"10.1016\/j.pharep.2015.05.027_bib0250","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nature06612","article-title":"Identification of a serotonin\/glutamate receptor complex implicated in psychosis","volume":"452","author":"Gonz\u00e1lez-Maeso","year":"2008","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.pharep.2015.05.027_bib0255","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1124\/mol.107.035170","article-title":"A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis","volume":"72","author":"Benneyworth","year":"2007","journal-title":"Mol Pharmacol"},{"issue":"1\u20132","key":"10.1016\/j.pharep.2015.05.027_bib0260","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0006-8993(99)01224-X","article-title":"Serotonin, via 5-HT2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release","volume":"825","author":"Aghajanian","year":"1999","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/j.pharep.2015.05.027_bib0265","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0022-3565(25)09485-6","article-title":"(1-(2,5-Dimethoxy-4 iodophenyl)-2-aminopropane)-induced head-twitches in the rat are mediated by 5-hydroxytryptamine (5-HT)2A receptors: modulation by novel 5-HT2A\/2C antagonists, D1 antagonists and 5-HT1A agonists","volume":"273","author":"Schreiber","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"issue":"4","key":"10.1016\/j.pharep.2015.05.027_bib0270","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0893-133X(00)00138-X","article-title":"Repeated phencyclidine treatment induces negative symptom-like behavior in forced swimming test in mice: imbalance of prefrontal serotonergic and dopaminergic functions","volume":"23","author":"Noda","year":"2000","journal-title":"Neuropsychopharmacology"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114015001140?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114015001140?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:36:08Z","timestamp":1752611768000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1016\/j.pharep.2015.05.027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S1734114015001140"],"URL":"https:\/\/doi.org\/10.1016\/j.pharep.2015.05.027","relation":{},"ISSN":["1734-1140"],"issn-type":[{"value":"1734-1140","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stimulation of the metabotropic glutamate (mGlu) 2 receptor attenuates the MK-801-induced increase in the immobility time in the forced swimming test in rats","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharep.2015.05.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.","name":"copyright","label":"Copyright"}]}}