{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:35:35Z","timestamp":1759336535519,"version":"3.41.2"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Reports"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.pharep.2015.06.139","type":"journal-article","created":{"date-parts":[[2015,7,17]],"date-time":"2015-07-17T21:24:11Z","timestamp":1437168251000},"page":"62-65","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["The anxiolytic-like activity of a novel N-cycloalkyl-N-benzoylpiperazine derivative"],"prefix":"10.1007","volume":"68","author":[{"given":"Daniel Jan","family":"Strub","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kinga","family":"Sa\u0142at","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadeusz","family":"Librowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanis\u0142aw","family":"Lochy\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Gawe\u0142","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Podkowa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"10.1016\/j.pharep.2015.06.139_bib0110","doi-asserted-by":"crossref","first-page":"839","DOI":"10.4088\/JCP.10r06218blu","article-title":"The pharmacologic treatment of anxiety disorders: a review of progress","volume":"71","author":"Ravindran","year":"2010","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pharep.2015.06.139_bib0115","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1021\/cn5000056","article-title":"Classics in chemical neuroscience: diazepam (valium)","volume":"5","author":"Calcaterra","year":"2014","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.pharep.2015.06.139_bib0120","series-title":"Tiagabine therapy for complex partial seizures. A dose-frequency study","first-page":"54","author":"Sachdeo","year":"1997"},{"key":"10.1016\/j.pharep.2015.06.139_bib0125","doi-asserted-by":"crossref","first-page":"187","DOI":"10.31887\/DCNS.2010.12.2\/mkellner","article-title":"Drug treatment of obsessive\u2013compulsive disorder","volume":"12","author":"Kellner","year":"2010","journal-title":"Dialogues Clin Neurosci"},{"key":"10.1016\/j.pharep.2015.06.139_bib0130","first-page":"300","article-title":"The diagnosis and treatment of generalized anxiety disorder","volume":"110","author":"Bandelow","year":"2013","journal-title":"Dtsch Arztebl Int"},{"key":"10.1016\/j.pharep.2015.06.139_bib0135","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S1734-1140(09)70136-7","article-title":"Analgesic activity of 3-mono-substituted derivatives of dihydrofuran-2-one in experimental rodent models of pain","volume":"61","author":"Sa\u0142at","year":"2009","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.pharep.2015.06.139_bib0140","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3109\/15376516.2013.879973","article-title":"Influence of analgesic active 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one on the antioxidant status, glucose utilization and lipid accumulation in some in vitro and ex vivo assays","volume":"24","author":"Sa\u0142at","year":"2014","journal-title":"Toxicol Mech Methods"},{"key":"10.1016\/j.pharep.2015.06.139_bib0145","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.pbb.2011.12.014","article-title":"Analgesic, anticonvulsant and antioxidant activities of 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one dihydrochloride in mice","volume":"101","author":"Salat","year":"2012","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pharep.2015.06.139_bib0150","first-page":"43","article-title":"Piperazine \u2013 pyrazine and their multiple biological activities","author":"Meher","year":"2013","journal-title":"Asian J Pharm Sci Res"},{"key":"10.1016\/j.pharep.2015.06.139_bib0155","unstructured":"Siemieniuk A, Sza\u0142kowska-Pagowska H, Lochy\u0144ski S, Piatkowski K, Filipek B, Krupi\u0144ska J, et al.;1; Synthesis and some pharmacological properties of 1,2-amino ethers with natural monoterpene structures. Pol J Pharmacol Pharm 44:187-200."},{"key":"10.1016\/j.pharep.2015.06.139_bib0160","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1177\/0269881110367726","article-title":"Opioids and anxiety","volume":"25","author":"Colasanti","year":"2011","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.pharep.2015.06.139_bib0165","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/FBP.0b013e3283566042","article-title":"Analgesic, antioedematous and antioxidant activity of \u03b3-butyrolactone derivatives in rodents","volume":"23","author":"Salat","year":"2012","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.pharep.2015.06.139_bib0170","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.pbb.2013.06.013","article-title":"Evaluation of anxiolytic-like, anticonvulsant, antidepressant-like and antinociceptive properties of new 2-substituted 4-hydroxybutanamides with affinity for GABA transporters in mice","volume":"110","author":"Sa\u0142at","year":"2013","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pharep.2015.06.139_bib0175","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.pharep.2014.08.013","article-title":"The antinociceptive effect and mechanisms of action of pregabalin in mice","volume":"67","author":"Kaygisiz","year":"2015","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.pharep.2015.06.139_bib0180","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.cmpb.2013.04.018","article-title":"The application of support vector regression for prediction of the antiallodynic effect of drug combinations in the mouse model of streptozocin-induced diabetic neuropathy","volume":"111","author":"Sa\u0142at","year":"2013","journal-title":"Comput Methods Programs Biomed"},{"key":"10.1016\/j.pharep.2015.06.139_bib0185","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/prac.19883300215","article-title":"Modification of synthesis of dihydrochrysanthemolactone from (+)-car-3-ene","volume":"330","author":"Lochy\u0144ski","year":"1988","journal-title":"J F\u00fcr Prakt Chem"},{"key":"10.1016\/j.pharep.2015.06.139_bib0190","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1021\/jo020658q","article-title":"Direct conversion of tert-beta-bromo alcohols to ketones with zinc sulfide and DMSO","volume":"68","author":"Bettadaiah","year":"2003","journal-title":"J Org Chem"},{"key":"10.1016\/j.pharep.2015.06.139_bib0195","doi-asserted-by":"crossref","first-page":"6925","DOI":"10.1016\/S0040-4039(02)01629-5","article-title":"Remarkable rate acceleration of the solvent-free Baeyer\u2013Villiger reaction on the surface of NaHCO3 crystals for sterically congested cyclic and acyclic ketones","volume":"43","author":"Yakura","year":"2002","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.pharep.2015.06.139_bib0200","doi-asserted-by":"crossref","first-page":"5595","DOI":"10.1016\/S0040-4039(00)97905-X","article-title":"Reductive amination of aldehydes and ketones by using sodium triacetoxyborohydride","volume":"31","author":"Abdel-Magid","year":"1990","journal-title":"Tetrahedron Lett"},{"year":"1997","series-title":"Drug Discovery and Evaluation. Pharmacological Assays","key":"10.1016\/j.pharep.2015.06.139_bib0205"},{"key":"10.1016\/j.pharep.2015.06.139_bib0210","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/FBP.0b013e32833e7e6d","article-title":"Evidence for the involvement of \u03bc-opioid and \u03b4-opioid receptors in the antinociceptive effect caused by oral administration of m-trifluoromethyl-diphenyl diselenide in mice","volume":"21","author":"Br\u00fcning","year":"2010","journal-title":"Behav Pharmacol"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114015002649?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114015002649?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:36:11Z","timestamp":1752611771000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1016\/j.pharep.2015.06.139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S1734114015002649"],"URL":"https:\/\/doi.org\/10.1016\/j.pharep.2015.06.139","relation":{},"ISSN":["1734-1140"],"issn-type":[{"type":"print","value":"1734-1140"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The anxiolytic-like activity of a novel N-cycloalkyl-N-benzoylpiperazine derivative","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharep.2015.06.139","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.","name":"copyright","label":"Copyright"}]}}