{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T19:19:56Z","timestamp":1771615196001,"version":"3.50.1"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001332","name":"CSIR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Reports"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.pharep.2015.10.003","type":"journal-article","created":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T20:08:35Z","timestamp":1445717315000},"page":"396-403","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Augmentation of effect of venlafaxine by folic acid in behavioral paradigms of depression in mice: Evidence of serotonergic and pro-inflammatory cytokine pathways"],"prefix":"10.1007","volume":"68","author":[{"given":"Jaya","family":"Thomas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Razia","family":"Khanam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1852-9191","authenticated-orcid":false,"given":"Divya","family":"Vohora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"issue":"Suppl. 26","key":"10.1016\/j.pharep.2015.10.003_bib0285","first-page":"5","article-title":"New standard of depression treatment: remission and full recovery","volume":"62","author":"Bakish","year":"2001","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pharep.2015.10.003_bib0290","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1741-7015-9-90","article-title":"Cross-national epidemiology of DSM-IV major depressive episode","volume":"9","author":"Bromet","year":"2011","journal-title":"BMC Med"},{"key":"10.1016\/j.pharep.2015.10.003_bib0295","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1126\/science.274.5288.740","article-title":"Evidence-based health policy \u2013 lessons from the Global Burden of Disease Study","volume":"274","author":"Murray","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.pharep.2015.10.003_bib0300","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/S0140-6736(96)07492-2","article-title":"Alternative projections of mortality and disability by cause 1990\u20132020: Global Burden of Disease Study","volume":"349","author":"Murray","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.pharep.2015.10.003_bib0305","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1001\/jama.289.23.3095","article-title":"The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R)","volume":"289","author":"Kessler","year":"2003","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.pharep.2015.10.003_bib0310","first-page":"343","article-title":"Getting the balance right: established and emerging therapies for major depressive disorders","volume":"6","author":"Perovic","year":"2010","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.1016\/j.pharep.2015.10.003_bib0315","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.pnpbp.2007.11.024","article-title":"Aripiprazole as an adjunctive treatment for refractory unipolar depression","volume":"32","author":"Hellerstein","year":"2008","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pharep.2015.10.003_bib0320","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.biopsych.2005.07.005","article-title":"Olanzapine augmentation of fluoxetine for refractory generalized anxiety disorder: a placebo controlled study","volume":"59","author":"Pollack","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharep.2015.10.003_bib0325","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1345\/aph.1K630","article-title":"Adjunctive aripiprazole for bupropion-resistant major depression","volume":"42","author":"Sokolski","year":"2008","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.pharep.2015.10.003_bib0330","doi-asserted-by":"crossref","first-page":"826","DOI":"10.4088\/JCP.v68n0602","article-title":"Augmentation of antidepressants with atypical antipsychotic medications for treatment-resistant major depressive disorder: a meta-analysis","volume":"68","author":"Papakostas","year":"2007","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pharep.2015.10.003_bib0335","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/YIC.0b013e32834ce13f","article-title":"Efficacy and tolerability of venlafaxine versus specific serotonin reuptake inhibitors in treatment of major depressive disorder: a meta-analysis of published studies","volume":"27","author":"de Silva","year":"2012","journal-title":"Int Clin Psychopharmacol"},{"key":"10.1016\/j.pharep.2015.10.003_bib0340","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1191\/096032799678840165","article-title":"Cardiovascular and neurological toxicity of venlafaxine","volume":"18","author":"Blythe","year":"1999","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.pharep.2015.10.003_bib0345","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3109\/10401230209147396","article-title":"Folinic acid (Leucovorin) as an adjunctive treatment for SSRI-refractory depression","volume":"14","author":"Alpert","year":"2002","journal-title":"Ann Clin Psychiatry"},{"key":"10.1016\/j.pharep.2015.10.003_bib0350","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/0140-6736(90)91942-4","article-title":"Enhancement of recovery from psychiatric illness by methylfolate","volume":"336","author":"Godfrey","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.pharep.2015.10.003_bib0355","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.pnpbp.2005.06.021","article-title":"Homocysteine and folate metabolism in depression","volume":"29","author":"Bottiglieri","year":"2005","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pharep.2015.10.003_bib0360","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.neuroscience.2011.05.053","article-title":"Neurotoxicity induced by dexamethasone in the human neuroblastoma SH-SY5Y cell line can be prevented by folic acid","volume":"190","author":"Budni","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharep.2015.10.003_bib0365","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jpsychires.2009.06.003","article-title":"Adjuvant use of nutritional and herbal medicines with antidepressants, mood stabilizers and benzodiazepines","volume":"44","author":"Sarris","year":"2010","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.pharep.2015.10.003_bib0370","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1038\/npp.2011.132","article-title":"The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a meta-analysis","volume":"36","author":"Hannestad","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharep.2015.10.003_bib0375","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/npp.2011.205","article-title":"Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior","volume":"37","author":"Haroon","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharep.2015.10.003_bib0380","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/PSY.0b013e3181907c1b","article-title":"Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis","volume":"71","author":"Howren","year":"2009","journal-title":"Psychosom Med"},{"key":"10.1016\/j.pharep.2015.10.003_bib0385","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.biopsych.2009.09.033","article-title":"A meta-analysis of cytokines in major depression","volume":"67","author":"Dowlati","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharep.2015.10.003_bib0390","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3109\/15622970802573246","article-title":"Pro-inflammatory biomakers in depression: treatment with venlafaxine","volume":"10","author":"Piletz","year":"2009","journal-title":"World J Biol Psychiatry"},{"key":"10.1016\/j.pharep.2015.10.003_bib0395","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1177\/039463201002300204","article-title":"The effect of newer serotonin\u2013noradrenalin antidepressants on cytokine production: a review of the current literature","volume":"23","author":"De Berardis","year":"2010","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1016\/j.pharep.2015.10.003_bib0400","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2334\/josnusd.43.255","article-title":"The effects of folic acid application on IL-1beta levels of human gingival fibroblasts stimulated by phenytoin and TNFalpha in vitro: a preliminary study","volume":"43","author":"Dogan","year":"2001","journal-title":"J Oral Sci"},{"key":"10.1016\/j.pharep.2015.10.003_bib0405","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.lfs.2010.01.013","article-title":"Involvement of potassium channels in the antidepressant-like effect of venlafaxine in mice","volume":"86","author":"Bortolatto","year":"2010","journal-title":"Life Sci"},{"key":"10.1016\/j.pharep.2015.10.003_bib0410","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.neuropharm.2007.10.016","article-title":"Folic acid administration produces an antidepressant-like effect in mice: evidence for the involvement of the serotonergic and noradrenergic systems","volume":"54","author":"Brocardo","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharep.2015.10.003_bib0415","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1365\/s10337-008-0879-9","article-title":"Determination of 5-hydroxytryptamine, norepinephrine, dopamine and their metabolites in rat brain tissue by LC\u2013ESI-MS\u2013MS","volume":"69","author":"Su","year":"2009","journal-title":"Chromatographia"},{"key":"10.1016\/j.pharep.2015.10.003_bib0420","first-page":"1","article-title":"A validated HPLC-UV method and optimization of sample preparation technique for norepinephrine and serotonin in mouse brain","author":"Thomas","year":"2015","journal-title":"Pharm Biol"},{"key":"10.1016\/j.pharep.2015.10.003_bib0425","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1017\/S1461145705005316","article-title":"Involvement of nitric oxide-cGMP pathway in the antidepressant-like effects of adenosine in the forced swimming test","volume":"8","author":"Kaster","year":"2005","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.pharep.2015.10.003_bib0430","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0166-4328(03)00069-X","article-title":"Involvement of NMDA receptors and l-arginine-nitric oxide pathway in the antidepressant-like effects of zinc in mice","volume":"144","author":"Rosa","year":"2003","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pharep.2015.10.003_bib0435","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1300\/J092v06n02_04","article-title":"Comparative study of antidepressants and herbal psychotropic drugs in a mouse model of chronic fatigue","volume":"6","author":"Kaur","year":"2000","journal-title":"J Chronic Fatigue Syndr"},{"key":"10.1016\/j.pharep.2015.10.003_bib0440","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.nbd.2008.05.003","article-title":"Fluoxetine increases the activity of the ERK\u2013CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress","volume":"31","author":"Qi","year":"2008","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.pharep.2015.10.003_bib0445","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pharep.2015.10.003_bib0450","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1093\/rheumatology\/33.10.927","article-title":"Serum cytokines (IL-6, TNF-alpha, IL-1 beta and IFN-gamma) in ankylosing spondylitis: a close correlation between serum IL-6 and disease activity and severity","volume":"33","author":"Gratacos","year":"1994","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.pharep.2015.10.003_bib0455","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0162-3109(96)00111-7","article-title":"Tricyclic antidepressants inhibit IL-6, IL-1 beta and TNF-alpha release in human blood monocytes and IL-2 and interferon-gamma in T cells","volume":"34","author":"Xia","year":"1996","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.pharep.2015.10.003_bib0460","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1002\/1529-0131(199912)42:12<2561::AID-ANR8>3.0.CO;2-U","article-title":"Fluoxetine and amitriptyline inhibit nitric oxide, prostaglandin E2, and hyaluronic acid production in human synovial cells and synovial tissue cultures","volume":"42","author":"Yaron","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.pharep.2015.10.003_bib0465","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.intimp.2003.11.006","article-title":"Stimulatory effect of antidepressants on the production of IL-6","volume":"4","author":"Kubera","year":"2004","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.pharep.2015.10.003_bib0470","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0893-133X(98)00088-8","article-title":"Negative immunoregulatory effects of antidepressants: inhibition of interferon-gamma and stimulation of interleukin-10 secretion","volume":"20","author":"Maes","year":"1999","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharep.2015.10.003_bib0475","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"10.1016\/j.pharep.2015.10.003_bib0480","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.neubiorev.2005.03.009","article-title":"The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice","volume":"29","author":"Cryan","year":"2005","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pharep.2015.10.003_bib0485","doi-asserted-by":"crossref","first-page":"c249","DOI":"10.1136\/bmj.c249","article-title":"Use of venlafaxine compared with other antidepressants and the risk of sudden cardiac death or near death: a nested case-control study","volume":"340","author":"Martinez","year":"2010","journal-title":"Br Med J"},{"key":"10.1016\/j.pharep.2015.10.003_bib0490","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s002130050638","article-title":"Dose-dependent noradrenergic and serotonergic properties of venlafaxine in animal models indicative of antidepressant activity","volume":"138","author":"Redrobe","year":"1998","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pharep.2015.10.003_bib0495","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.pnpbp.2007.02.008","article-title":"Involvement of l-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of venlafaxine in mice","volume":"31","author":"Dhir","year":"2007","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pharep.2015.10.003_bib0500","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000151527","article-title":"Effect of folic acid combined with fluoxetine in patients with major depression on plasma homocysteine and vitamin B12, and serotonin levels in lymphocytes","volume":"15","author":"Resler","year":"2008","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.pharep.2015.10.003_bib0505","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1146\/annurev.pa.13.040173.002235","article-title":"Neuropharmacology of the affective disorders","volume":"13","author":"Schildkraut","year":"1973","journal-title":"Annu Rev Pharmacol"},{"key":"10.1016\/j.pharep.2015.10.003_bib0510","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1176\/jnp.7.4.524","article-title":"The catecholamine hypothesis of affective disorders: a review of supporting evidence. 1965","volume":"7","author":"Schildkraut","year":"1995","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"10.1016\/j.pharep.2015.10.003_bib0515","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S0006-3223(00)00978-1","article-title":"Neuropathology of bipolar disorder","volume":"48","author":"Vawter","year":"2000","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharep.2015.10.003_bib0520","first-page":"17","article-title":"Antidepressant therapy with milnacipran and venlafaxine","volume":"6","author":"Mansuy","year":"2010","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.1016\/j.pharep.2015.10.003_bib0525","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.pnpbp.2010.08.026","article-title":"In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression","volume":"35","author":"Kubera","year":"2011","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pharep.2015.10.003_bib0530","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1684\/ecn.2013.0338","article-title":"Stress-induced cytokine changes in rats","volume":"24","author":"Himmerich","year":"2013","journal-title":"Eur Cytokine Netw"},{"key":"10.1016\/j.pharep.2015.10.003_bib0535","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.jpsychires.2013.01.007","article-title":"Antidepressant effects of TNF-alpha blockade in an animal model of depression","volume":"47","author":"Krugel","year":"2013","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.pharep.2015.10.003_bib0540","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s00011-011-0337-2","article-title":"Folic acid inhibits lipopolysaccharide-induced inflammatory response in RAW264. 7 macrophages by suppressing MAPKs and NF-\u03baB activation","volume":"60","author":"Feng","year":"2011","journal-title":"Inflamm Res"},{"key":"10.1016\/j.pharep.2015.10.003_bib0545","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0024-3205(97)00990-9","article-title":"Depression, stress and immunological activation: the role of cytokines in depressive disorders","volume":"62","author":"Connor","year":"1998","journal-title":"Life Sci"},{"key":"10.1016\/j.pharep.2015.10.003_bib0550","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/sj.mp.4000586","article-title":"The role of inflammatory mediators in the biology of major depression: central nervous system cytokines modulate the biological substrate of depressive symptoms, regulate stress-responsive systems, and contribute to neurotoxicity and neuroprotection","volume":"4","author":"Licinio","year":"1999","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pharep.2015.10.003_bib0555","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/00004714-200202000-00014","article-title":"Increased depressive ratings in patients with hepatitis C receiving interferon-alpha-based immunotherapy are related to interferon-alpha-induced changes in the serotonergic system","volume":"22","author":"Bonaccorso","year":"2002","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.pharep.2015.10.003_bib0560","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3109\/08830180903349669","article-title":"Dendritic cells, indoleamine 2,3 dioxygenase and acquired immune privilege","volume":"29","author":"Huang","year":"2010","journal-title":"Int Rev Immunol"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114015003400?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114015003400?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:36:18Z","timestamp":1752611778000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1016\/j.pharep.2015.10.003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S1734114015003400"],"URL":"https:\/\/doi.org\/10.1016\/j.pharep.2015.10.003","relation":{},"ISSN":["1734-1140"],"issn-type":[{"value":"1734-1140","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Augmentation of effect of venlafaxine by folic acid in behavioral paradigms of depression in mice: Evidence of serotonergic and pro-inflammatory cytokine pathways","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharep.2015.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Sp. z o.o. All rights reserved.","name":"copyright","label":"Copyright"}]}}