{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T14:24:27Z","timestamp":1754144667174,"version":"3.41.2"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Reports"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.pharep.2016.05.004","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T20:13:41Z","timestamp":1467231221000},"page":"952-959","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Protective effects of MCR-1329, a dual \u03b11 and angII receptor antagonist, in mineralocorticoid-induced hypertension"],"prefix":"10.1007","volume":"68","author":[{"given":"Hardik","family":"Gandhi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prashant","family":"Naik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitesh","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mangeram","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"10.1016\/j.pharep.2016.05.004_bib0235","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1056\/NEJM200101043440101","article-title":"Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet","volume":"344","author":"Sacks","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharep.2016.05.004_bib0240","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1046\/j.1365-2125.1999.00092.x","article-title":"Prospective Diabetes Study (UKPDS): clinical and therapeutic implications for type 2 diabetes","volume":"48","author":"King","year":"1999","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.pharep.2016.05.004_bib0245","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3317\/jraas.2000.002","article-title":"The HOPE Study (Heart Outcomes Prevention Evaluation)","volume":"1","author":"Sleight","year":"2000","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"key":"10.1016\/j.pharep.2016.05.004_bib0250","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/qjmed\/hcg123","article-title":"The ALLHAT study: results and clinical implications","volume":"96","author":"Chrysant","year":"2003","journal-title":"Q J Med"},{"key":"10.1016\/j.pharep.2016.05.004_bib0255","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1001\/jama.290.21.2805","article-title":"A calcium antagonist vs. a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trial","volume":"290","author":"Pepine","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.pharep.2016.05.004_bib0260","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2174\/15748847113086660075","article-title":"Management of hypertension-journey from single drug therapy to multitargeted ligand therapy: a clinical overview","volume":"10","author":"Naik","year":"2015","journal-title":"Curr Clin Pharmacol"},{"key":"10.1016\/j.pharep.2016.05.004_bib0265","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3109\/13880209.2011.611144","article-title":"Revelation on the potency of \u03b11-blockers \u2013 parallel blockade of angiotensin II receptor: a new finding","volume":"50","author":"Yadav","year":"2012","journal-title":"Pharm Biol"},{"key":"10.1016\/j.pharep.2016.05.004_bib0270","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1042\/CS20120424","article-title":"Angiotensin II potentiates \u03b1-adrenergic vasoconstriction in the elderly","volume":"124","author":"Barrett-O\u2019Keefe","year":"2013","journal-title":"Clin Sci"},{"key":"10.1016\/j.pharep.2016.05.004_bib0275","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/CRD.0b013e31829ce723","article-title":"Alpha-1 adrenoceptor\u2013angiotensin II type 1 receptor cross-talk and its relevance in clinical medicine","volume":"22","author":"Vittorio","year":"2014","journal-title":"Cardiol Rev"},{"key":"10.1016\/j.pharep.2016.05.004_bib0280","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1093\/cvr\/cvs166","article-title":"PI3K\u03b3 in hypertension: a novel therapeutic target controlling vascular myogenic tone and target organ damage","volume":"95","author":"Carnevale","year":"2012","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pharep.2016.05.004_bib0285","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1161\/01.RES.0000022200.71892.9F","article-title":"Role of Akt signaling in vascular homeostasis and angiogenesis","volume":"90","author":"Shiojima","year":"2002","journal-title":"Circ Res"},{"key":"10.1016\/j.pharep.2016.05.004_bib0290","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00424-010-0847-8","article-title":"Canonical TRP channels and mechanotransduction: from physiology to disease states","volume":"460","author":"Patel","year":"2010","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.pharep.2016.05.004_bib0295","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1074\/jbc.M409590200","article-title":"Mechanical stretch stimulates protein kinase b\/Akt phosphorylation in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptor","volume":"280","author":"Kippenberger","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharep.2016.05.004_bib0300","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/nn1300","article-title":"PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane","volume":"7","author":"Viard","year":"2004","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pharep.2016.05.004_bib0305","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1472-6793-5-9","article-title":"PI3K and PKC contribute to membrane depolarization mediated by \u03b12-adrenoceptors in the canine isolated mesenteric vein","volume":"5","author":"Yamboliev","year":"2005","journal-title":"BMC Physiol"},{"key":"10.1016\/j.pharep.2016.05.004_bib0310","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1124\/jpet.104.082784","article-title":"Opposing roles of endothelial and smooth muscle phosphatidylinositol 3-kinase in vasoconstriction: effects of rho-kinase and hypertension","volume":"313","author":"Budzyn","year":"2005","journal-title":"J Pharmacol Exp Therap"},{"key":"10.1016\/j.pharep.2016.05.004_bib0315","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1016\/j.bmcl.2013.04.054","article-title":"Design and synthesis of 6,7-dimethoxyquinazoline analogs as multi-targeted ligands for \u03b11-and AII-receptors antagonism","volume":"23","author":"Yadav","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.pharep.2016.05.004_bib0320","doi-asserted-by":"crossref","first-page":"190","DOI":"10.2174\/1570180811666141010000716","article-title":"6,7-Dimethoxyquinazolines as potential cytotoxic agents: synthesis and in vitro activity","volume":"12","author":"Yadav","year":"2015","journal-title":"Lett Drug Des Discov"},{"year":"1999","series-title":"Histological and histochemical methods: theory and practice","key":"10.1016\/j.pharep.2016.05.004_bib0325"},{"key":"10.1016\/j.pharep.2016.05.004_bib0330","first-page":"349","article-title":"Animal models of hypertension and effect of drugs","volume":"35","author":"Badyal","year":"2003","journal-title":"Ind J Pharmacol"},{"key":"10.1016\/j.pharep.2016.05.004_bib0335","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3109\/10641960902993111","article-title":"Evaluation of renal oxidative stress in the development of DOCA-salt induced hypertension and its renal damage","volume":"32","author":"Seifi","year":"2010","journal-title":"Clin Exp Hypertens"},{"key":"10.1016\/j.pharep.2016.05.004_bib0340","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1161\/01.HYP.0000214362.18612.6e","article-title":"Deoxycorticosterone acetate-salt rats hypertension and sympathoexcitation driven by increased NaCl levels","volume":"47","author":"O\u2019Donaughy","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.pharep.2016.05.004_bib0345","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/1056-8719(92)90036-Z","article-title":"The pathogenesis of DOCA-salt hypertension","volume":"27","author":"Schenk","year":"1992","journal-title":"J Pharmacol Toxicol Methods"},{"key":"10.1016\/j.pharep.2016.05.004_bib0350","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1210\/en.2007-0864","article-title":"Aldosterone induces superoxide generation via Rac1 activation in endothelial cells","volume":"149","author":"Iwashima","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.pharep.2016.05.004_bib0355","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1161\/01.HYP.0000088363.65943.6C","article-title":"ETA receptor blockade decreases vascular superoxide generation in DOCA-salt hypertension","volume":"42","author":"Callera","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.pharep.2016.05.004_bib0360","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1124\/jpet.109.164871","article-title":"Heme arginate therapy enhanced adiponectin and atrial natriuretic peptide, but abated endothelin-1 with attenuation of kidney histopathological lesions in mineralocorticoid-induced hypertension","volume":"334","author":"Ndisang","year":"2010","journal-title":"J Pharmacol Exp Therap"},{"key":"10.1016\/j.pharep.2016.05.004_bib0365","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1161\/HYPERTENSIONAHA.113.02883","article-title":"Spironolactone decreases DOCA-salt-induced organ damage by blocking the activation of T helper 17 and the downregulation of regulatory T lymphocytes","volume":"63","author":"Amador","year":"2014","journal-title":"Hypertension"},{"issue":"1 Suppl.","key":"10.1016\/j.pharep.2016.05.004_bib0370","first-page":"987","article-title":"Central inhibition of bradykinin B1 receptor attenuates DOCA-salt mediated hypertension, dysautonomia and hypertrophy","volume":"29","author":"Sriramula","year":"2015","journal-title":"FASEB J"},{"key":"10.1016\/j.pharep.2016.05.004_bib0375","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1161\/HYPERTENSIONAHA.109.144840","article-title":"mPGES-1 protects against DOCA-salt hypertension via inhibition of oxidative stress or stimulation of NO\/cGMP","volume":"55","author":"Jia","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.pharep.2016.05.004_bib0380","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000235774","article-title":"Increased renal proximal convoluted tubule transport contributes to hypertension in Cyp4a14 knockout mice","volume":"113","author":"Quigley","year":"2009","journal-title":"Nephron Physiol"},{"key":"10.1016\/j.pharep.2016.05.004_bib0385","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1056\/NEJM198606123142404","article-title":"Effect of vasodilator therapy on mortality in chronic congestive heart failure. Results of a Veterans Administration Cooperative Study","volume":"314","author":"Cohn","year":"1986","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharep.2016.05.004_bib0390","series-title":"Transplantation proceedings","article-title":"Proteinuria\/creatininuria index and its correlation with the 24-hour proteinuria in renal transplanted patients","author":"Mombelli","year":"2013"},{"key":"10.1016\/j.pharep.2016.05.004_bib0395","doi-asserted-by":"crossref","first-page":"H1891","DOI":"10.1152\/ajpheart.00655.2010","article-title":"2,3\u2032,4,5\u2032-Tetramethoxystilbene prevents deoxycorticosterone-salt-induced hypertension: contribution of cytochrome P-450 1B1","volume":"299","author":"Sahan-Firat","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.pharep.2016.05.004_bib0400","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/HJH.0b013e32834103ee","article-title":"Renal protective effects of N-acetyl-Ser-Asp-Lys-Pro in DOCA-salt hypertensive mice","volume":"29","author":"Rhaleb","year":"2011","journal-title":"J Hypertens"},{"key":"10.1016\/j.pharep.2016.05.004_bib0405","first-page":"54","article-title":"Progression of renal damage in the obese Zucker rat in response to deoxycorticosterone acetate-salt-induced hypertension","volume":"35","author":"Morrison","year":"2005","journal-title":"Ann Clin Lab Sci"},{"key":"10.1016\/j.pharep.2016.05.004_bib0410","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s007260070014","article-title":"Effects of high salt diets and taurine on the development of hypertension in the stroke-prone spontaneously hypertensive rat","volume":"19","author":"Dawson","year":"2000","journal-title":"Amino Acids"},{"key":"10.1016\/j.pharep.2016.05.004_bib0415","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.regpep.2009.04.015","article-title":"Altered regulation of renal sodium transporters and natriuretic peptide system in DOCA-salt hypertensive rats","volume":"157","author":"Bae","year":"2009","journal-title":"Reg Peptides"},{"key":"10.1016\/j.pharep.2016.05.004_bib0420","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1038\/ki.1994.404","article-title":"Contribution of renal angiotensin II type I receptor to gene expressions in hypertension-induced renal injury","volume":"46","author":"Kim","year":"1994","journal-title":"Kidney Int"},{"key":"10.1016\/j.pharep.2016.05.004_bib0425","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1124\/jpet.109.160184","article-title":"Uric acid does not affect the acetylcholine-induced relaxation of aorta from normotensive and deoxycorticosterone acetate-salt hypertensive rats","volume":"333","author":"Szasz","year":"2010","journal-title":"J Pharmacol Exp Therap"},{"key":"10.1016\/j.pharep.2016.05.004_bib0430","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1523\/JNEUROSCI.19-07-02413.1999","article-title":"Role of phosphatidylinositol 3-kinase in angiotensin II regulation of norepinephrine neuromodulation in brain neurons of the spontaneously hypertensive rat","volume":"19","author":"Yang","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharep.2016.05.004_bib0435","doi-asserted-by":"crossref","first-page":"32545","DOI":"10.1074\/jbc.M102582200","article-title":"Phosphoinositide 3-kinase\u03b3 mediates angiotensin II-induced stimulation of L-type calcium channels in vascular myocytes","volume":"276","author":"Quignard","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharep.2016.05.004_bib0440","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1161\/01.RES.81.2.249","article-title":"Angiotensin II activates phosphatidylinositol-3-kinase in vascular smooth muscle cells","volume":"81","author":"Saward","year":"1997","journal-title":"Circ Res"},{"key":"10.1016\/j.pharep.2016.05.004_bib0445","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1038\/sj.onc.1202527","article-title":"VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells","volume":"18","author":"Takahashi","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.pharep.2016.05.004_bib0450","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1161\/01.HYP.0000060821.62417.35","article-title":"Akt is a major downstream target of PI3-kinase involved in angiotensin II-induced proliferation","volume":"41","author":"Dugourd","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.pharep.2016.05.004_bib0455","doi-asserted-by":"crossref","first-page":"H2306","DOI":"10.1152\/ajpheart.00571.2004","article-title":"Angiotensin II-induced Akt activation is mediated by metabolites of arachidonic acid generated by CaMKII-stimulated Ca2+-dependent phospholipase A2","volume":"288","author":"Li","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.pharep.2016.05.004_bib0460","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1210\/en.2004-1026","article-title":"Epidermal growth factor facilitates epinephrine inhibition of P2X7-receptor-mediated pore formation and apoptosis: a novel signaling network","volume":"146","author":"Wang","year":"2005","journal-title":"Endocrinology"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114016300445?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114016300445?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:36:32Z","timestamp":1752611792000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1016\/j.pharep.2016.05.004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S1734114016300445"],"URL":"https:\/\/doi.org\/10.1016\/j.pharep.2016.05.004","relation":{},"ISSN":["1734-1140"],"issn-type":[{"type":"print","value":"1734-1140"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effects of MCR-1329, a dual \u03b11 and angII receptor antagonist, in mineralocorticoid-induced hypertension","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharep.2016.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Urban & Partner Sp. z o.o. on behalf of Institute of Pharmacology, Polish Academy of Sciences.","name":"copyright","label":"Copyright"}]}}