{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T13:17:35Z","timestamp":1772803055056,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271222"],"award-info":[{"award-number":["81271222"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hubei Province Health and Family Planning Scientific Research Project","award":["WJ2015MB219"],"award-info":[{"award-number":["WJ2015MB219"]}]},{"DOI":"10.13039\/501100003819","name":"Hubei Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2015CFB260"],"award-info":[{"award-number":["2015CFB260"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shiyan Nature Science Foundation","award":["15K70"],"award-info":[{"award-number":["15K70"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Reports"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.pharep.2016.05.006","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T23:15:02Z","timestamp":1467328502000},"page":"975-982","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Hydrogen sulfide down-regulates BACE1 and PS1 via activating PI3K\/Akt pathway in the brain of APP\/PS1 transgenic mouse"],"prefix":"10.1007","volume":"68","author":[{"given":"Xuan-li","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-shan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-wen","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyou","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"issue":"2","key":"10.1016\/j.pharep.2016.05.006_bib0165","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/(SICI)1097-0274(199902)35:2<192::AID-AJIM11>3.0.CO;2-C","article-title":"Hydrogen sulfide poisoning: clarification of some controversial issues","volume":"35","author":"Milby","year":"1999","journal-title":"Am J Ind Med"},{"issue":"3","key":"10.1016\/j.pharep.2016.05.006_bib0170","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.acthis.2008.11.004","article-title":"Nervous control of circulation \u2013 the role of gasotransmitters, NO, CO, and H2S","volume":"111","author":"Olson","year":"2009","journal-title":"Acta Histochem"},{"issue":"13","key":"10.1016\/j.pharep.2016.05.006_bib0175","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1096\/fj.02-0211hyp","article-title":"Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?","volume":"16","author":"Wang","year":"2002","journal-title":"FASEB J"},{"issue":"3","key":"10.1016\/j.pharep.2016.05.006_bib0180","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996","article-title":"The possible role of hydrogen sulfide as an endogenous neuromodulator","volume":"16","author":"Abe","year":"1996","journal-title":"J Neurosci"},{"issue":"3","key":"10.1016\/j.pharep.2016.05.006_bib0185","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00726-004-0072-x","article-title":"Endogenous production of hydrogen sulfide in mammals","volume":"26","author":"Kamoun","year":"2004","journal-title":"Amino Acids"},{"issue":"9","key":"10.1016\/j.pharep.2016.05.006_bib0190","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1080\/15216540500217875","article-title":"Hydrogen sulfide as a vasodilator","volume":"57","author":"Bhatia","year":"2005","journal-title":"IUBMB Life"},{"issue":"6","key":"10.1016\/j.pharep.2016.05.006_bib0195","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1161\/HYPERTENSIONAHA.114.04376","article-title":"Novel role for protein kinase g oxidative activation in the vasodilator and antihypertensive actions of hydrogen sulfide","volume":"64","author":"Wolin","year":"2014","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.pharep.2016.05.006_bib0200","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1053\/j.gastro.2006.08.035","article-title":"Hydrogen sulfide is a novel prosecretory neuromodulator in the Guinea-pig and human colon","volume":"131","author":"Schicho","year":"2006","journal-title":"Gastroenterology"},{"issue":"10","key":"10.1016\/j.pharep.2016.05.006_bib0205","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1021\/cn500185g","article-title":"Hydrogen sulfide: a neuromodulator and neuroprotectant in the central nervous system","volume":"5","author":"Zhang","year":"2014","journal-title":"ACS Chem Neurosci"},{"issue":"5","key":"10.1016\/j.pharep.2016.05.006_bib0210","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.2337\/db05-1082","article-title":"l-Cysteine inhibits insulin release from the pancreatic beta-cell: possible involvement of metabolic production of hydrogen sulfide, a novel gasotransmitter","volume":"55","author":"Kaneko","year":"2006","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.pharep.2016.05.006_bib0215","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1471-4159.2004.02617.x","article-title":"The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite \u2018scavenger\u2019?","volume":"90","author":"Whiteman","year":"2004","journal-title":"J Neurochem"},{"issue":"3","key":"10.1016\/j.pharep.2016.05.006_bib0220","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/jnr.23504","article-title":"Hydrogen sulfide functions as a neuromodulator to regulate striatal neurotransmission in a mouse model of Parkinson's disease","volume":"93","author":"Wang","year":"2015","journal-title":"J Neurosci Res"},{"issue":"2","key":"10.1016\/j.pharep.2016.05.006_bib0225","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1124\/jpet.105.092023","article-title":"Role of hydrogen sulfide in the cardioprotection caused by ischemic preconditioning in the rat heart and cardiac myocytes","volume":"316","author":"Bian","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"issue":"4","key":"10.1016\/j.pharep.2016.05.006_bib0230","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1111\/j.1471-4159.2006.04283.x","article-title":"Hydrogen sulfide attenuates lipopolysaccharide-induced inflammation by inhibition of p38 mitogen-activated protein kinase in microglia","volume":"100","author":"Hu","year":"2007","journal-title":"J Neurochem"},{"issue":"3","key":"10.1016\/j.pharep.2016.05.006_bib0235","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/SHK.0b013e318180ff89","article-title":"Anti-apoptotic and anti-inflammatory effects of hydrogen sulfide in a rat model of regional myocardial I\/R","volume":"31","author":"Sivarajah","year":"2009","journal-title":"Shock"},{"issue":"12","key":"10.1016\/j.pharep.2016.05.006_bib0240","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.freeradbiomed.2008.09.014","article-title":"Hydrogen sulfide protects astrocytes against H(2)O(2)-induced neural injury via enhancing glutamate uptake","volume":"45","author":"Lu","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.pharep.2016.05.006_bib0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuint.2014.01.004","article-title":"Hydrogen sulfide improves spatial memory impairment and decreases production of Abeta in APP\/PS1 transgenic mice","volume":"67","author":"He","year":"2014","journal-title":"Neurochem Int"},{"issue":"2","key":"10.1016\/j.pharep.2016.05.006_bib0250","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.bbrc.2007.10.167","article-title":"PI3-K- and PKC-dependent up-regulation of APP processing enzymes by retinoic acid","volume":"365","author":"Holback","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"10.1016\/j.pharep.2016.05.006_bib0255","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1096\/fasebj.14.7.1015","article-title":"Insulin regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway","volume":"14","author":"Solano","year":"2000","journal-title":"FASEB J"},{"issue":"1","key":"10.1016\/j.pharep.2016.05.006_bib0260","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0006-291X(02)02999-6","article-title":"Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase","volume":"301","author":"Asai","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.pharep.2016.05.006_bib0265","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cardiores.2007.05.026","article-title":"The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation","volume":"76","author":"Cai","year":"2007","journal-title":"Cardiovasc Res"},{"issue":"32","key":"10.1016\/j.pharep.2016.05.006_bib0270","first-page":"2246","article-title":"[Plasma levels of endogenous hydrogen sulfide and homocysteine in patients with Alzheimer's disease and vascular dementia and the significance thereof]","volume":"88","author":"Liu","year":"2008","journal-title":"Zhonghua Yi Xue Za Zhi"},{"issue":"3","key":"10.1016\/j.pharep.2016.05.006_bib0275","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.nbd.2006.08.017","article-title":"Characterization of amyloid deposition in the APPswe\/PS1dE9 mouse model of Alzheimer disease","volume":"24","author":"Garcia-Alloza","year":"2006","journal-title":"Neurobiol Dis"},{"issue":"2","key":"10.1016\/j.pharep.2016.05.006_bib0280","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jnutbio.2013.09.015","article-title":"Special lipid-based diets alleviate cognitive deficits in the APPswe\/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition","volume":"25","author":"Koivisto","year":"2014","journal-title":"J Nutr Biochem"},{"issue":"6","key":"10.1016\/j.pharep.2016.05.006_bib0285","doi-asserted-by":"crossref","first-page":"531","DOI":"10.2174\/156720509790147070","article-title":"Amyloid deposition and inflammation in APPswe\/PS1dE9 mouse model of Alzheimer's disease","volume":"6","author":"Ruan","year":"2009","journal-title":"Curr Alzheimer Res"},{"issue":"5","key":"10.1016\/j.pharep.2016.05.006_bib0290","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/j.1471-4159.2012.07834.x","article-title":"Beta-amyloid 1\u201342 induces physiological transcriptional regulation of BACE1","volume":"122","author":"Piccini","year":"2012","journal-title":"J Neurochem"},{"issue":"1","key":"10.1016\/j.pharep.2016.05.006_bib0295","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11357-008-9076-x","article-title":"Reduced neuronal co-localisation of nardilysin and the putative alpha-secretases ADAM10 and ADAM17 in Alzheimer's disease and Down syndrome brains","volume":"31","author":"Bernstein","year":"2009","journal-title":"Age (Dordr)"},{"issue":"14","key":"10.1016\/j.pharep.2016.05.006_bib0300","doi-asserted-by":"crossref","first-page":"9027","DOI":"10.1074\/jbc.M805685200","article-title":"Mutant presenilin 1 increases the expression and activity of BACE1","volume":"284","author":"Giliberto","year":"2009","journal-title":"J Biol Chem"},{"issue":"3\u20135","key":"10.1016\/j.pharep.2016.05.006_bib0305","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0736-5748(02)00047-3","article-title":"Functions of PI 3-kinase in development of the nervous system","volume":"20","author":"Rodgers","year":"2002","journal-title":"Int J Dev Neurosci"},{"issue":"5240","key":"10.1016\/j.pharep.2016.05.006_bib0310","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1126\/science.270.5240.1326","article-title":"Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis","volume":"270","author":"Xia","year":"1995","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.pharep.2016.05.006_bib0315","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1128\/MCB.19.4.2435","article-title":"Mitogen-activated protein kinases: specific messages from ubiquitous messengers","volume":"19","author":"Schaeffer","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.pharep.2016.05.006_bib0320","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/1742-2094-9-202","article-title":"Hydrogen sulfide attenuates spatial memory impairment and hippocampal neuroinflammation in beta-amyloid rat model of Alzheimer's disease","volume":"9","author":"Xuan","year":"2012","journal-title":"J Neuroinflamm"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114016300469?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114016300469?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:36:32Z","timestamp":1752611792000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1016\/j.pharep.2016.05.006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S1734114016300469"],"URL":"https:\/\/doi.org\/10.1016\/j.pharep.2016.05.006","relation":{},"ISSN":["1734-1140"],"issn-type":[{"value":"1734-1140","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydrogen sulfide down-regulates BACE1 and PS1 via activating PI3K\/Akt pathway in the brain of APP\/PS1 transgenic mouse","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharep.2016.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.","name":"copyright","label":"Copyright"}]}}