{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T12:10:31Z","timestamp":1788610231026,"version":"build-2803163510"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Reports"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.pharep.2016.06.005","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T04:31:27Z","timestamp":1473395487000},"page":"1159-1164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Cerebellar level of neurotransmitters in rats exposed to paracetamol during development"],"prefix":"10.1007","volume":"68","author":[{"given":"Kamilla","family":"Blecharz-Klin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona","family":"Joniec-Maciejak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Jawna-Zboi\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Pyrzanowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Piechal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Wawer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Widy-Tyszkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"issue":"178","key":"10.1016\/j.pharep.2016.06.005_bib0005","first-page":"e1","article-title":"Acetaminophen use during pregnancy: effects on risk for congenital abnormalities","volume":"198","author":"Rebordosa","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.pharep.2016.06.005_bib0010","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/ije\/dyn070","article-title":"Pre-natal exposure to paracetamol and risk of wheezing and asthma in children: a birth cohort study","volume":"37","author":"Rebordosa","year":"2008","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.pharep.2016.06.005_bib0015","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1093\/ije\/dyp151","article-title":"Use of acetaminophen during pregnancy and risk of adverse pregnancy outcomes","volume":"38","author":"Rebordosa","year":"2009","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.pharep.2016.06.005_bib0020","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.reprotox.2010.07.007","article-title":"A review of the literature on the effects of acetaminophen on pregnancy outcome","volume":"30","author":"Scialli","year":"2010","journal-title":"Reprod Toxicol"},{"issue":"Suppl","key":"10.1016\/j.pharep.2016.06.005_bib0025","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/978-3-642-68560-6_2","article-title":"Morphological development of the rat cerebellum and some of its mechanisms","volume":"6","author":"Altman","year":"1982","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.pharep.2016.06.005_bib0030","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1113\/jphysiol.2005.089383","article-title":"Physiological and morphological development of the rat cerebellar Purkinje cell","volume":"567","author":"McKay","year":"2005","journal-title":"J Physiol"},{"key":"10.1016\/j.pharep.2016.06.005_bib0035","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1111\/j.1460-9592.2008.02764.x","article-title":"Paracetamol (Acetaminophen): mechanisms of action","volume":"18","author":"Anderson","year":"2008","journal-title":"Paediatr Anaesth"},{"key":"10.1016\/j.pharep.2016.06.005_bib0040","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1460-9592.2008.02535.x","article-title":"Hepatic tolerance of repeated intravenous paracetamol administration in neonates","volume":"18","author":"Allegaert","year":"2008","journal-title":"Paediatr Anaesth"},{"key":"10.1016\/j.pharep.2016.06.005_bib0045","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/FTD.0b013e3181a8cc0a","article-title":"In vivo glucuronidation activity of drugs in neonates: extensive interindividual variability despite their young age","volume":"31","author":"Allegaert","year":"2009","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.pharep.2016.06.005_bib0050","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1136\/adc.2010.204552","article-title":"The pharmacokinetics of intravenous paracetamol in neonates: size matters most","volume":"96","author":"Allegaert","year":"2011","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.pharep.2016.06.005_bib0055","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s00228-010-0860-z","article-title":"Haemodynamics of intravenous paracetamol in neonates","volume":"66","author":"Allegaert","year":"2010","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.pharep.2016.06.005_bib0060","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1590\/S0103-05822014000100021","article-title":"Acute liver failure in a term neonate after repeated paracetamol administration","volume":"32","author":"Bucaretchi","year":"2014","journal-title":"Rev Paul Pediatr"},{"key":"10.1016\/j.pharep.2016.06.005_bib0065","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00228-011-1165-6","article-title":"Lack of toxicity after paracetamol overdose in a extremely preterm neonate","volume":"68","author":"Porta","year":"2012","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.pharep.2016.06.005_bib0070","doi-asserted-by":"crossref","first-page":"F59","DOI":"10.1136\/fn.80.1.F59","article-title":"Pharmacokinetics and metabolism of rectally administered paracetamol in preterm neonates","volume":"80","author":"vanLingen","year":"1999","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.pharep.2016.06.005_bib0075","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1093\/ije\/dyt183","article-title":"Prenatal paracetamol exposure and child neurodevelopment: a sibling-controlled cohort study","volume":"42","author":"Brandlistuen","year":"2013","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.pharep.2016.06.005_bib0080","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1111\/j.1460-9568.2012.08032.x","article-title":"Prostaglandin E2 is an endogenous modulator of cerebellar development and complex behavior during a sensitive postnatal period","volume":"35","author":"Dean","year":"2012","journal-title":"Eur J Neurosci"},{"issue":"3","key":"10.1016\/j.pharep.2016.06.005_bib0085","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1080\/14734220601169707","article-title":"Cerebellar involvement in executive control","volume":"6","author":"Bellebaum","year":"2007","journal-title":"Cerebellum"},{"key":"10.1016\/j.pharep.2016.06.005_bib0090","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.etap.2015.07.001","article-title":"Developmental exposure to paracetamol causes biochemical alterations in medulla oblongata","volume":"40","author":"Blecharz-Klin","year":"2015","journal-title":"Environ Toxicol Pharmacol"},{"key":"10.1016\/j.pharep.2016.06.005_bib0095","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.ajog.2005.02.100","article-title":"Use of over the-counter medications during pregnancy","volume":"193","author":"Werler","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.pharep.2016.06.005_bib0100","first-page":"311","article-title":"Intravenous paracetamol in pediatrics: a global perspective","volume":"16","author":"Irshad","year":"2012","journal-title":"Anaesth. Pain Intensive Care"},{"key":"10.1016\/j.pharep.2016.06.005_bib0105","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.curtheres.2014.12.001","article-title":"Clinical pharmacology of paracetamol in neonates: a review","volume":"77","author":"Pacifici","year":"2015","journal-title":"Curr Ther Res Clin Exp"},{"key":"10.1016\/j.pharep.2016.06.005_bib0110","first-page":"135","article-title":"Disposition of acetaminophen in milk, saliva and plasma of lactating women","volume":"1","author":"Berlin","year":"1980","journal-title":"Pediatr Pharmacol"},{"key":"10.1016\/j.pharep.2016.06.005_bib0115","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF00607148","article-title":"Excretion of paracetamol in human breast milk","volume":"20","author":"Bitzen","year":"1981","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.pharep.2016.06.005_bib0120","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1365-2125.1987.tb03137.x","article-title":"Passage of paracetamol into breast milk and its subsequent metabolism by the neonate","volume":"24","author":"Notarianni","year":"1987","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.pharep.2016.06.005_bib0125","series-title":"Paracetamol\u2014Long-Term Exposure in Pregnancy and Risk of Adverse Neurodevelopmental Outcome","article-title":"PRAC recommendation (Pharmacovigilance Risk Assessment)","author":"EMA","year":"2016"},{"key":"10.1016\/j.pharep.2016.06.005_bib0130","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s10787-013-0172-x","article-title":"The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings","volume":"21","author":"Graham","year":"2013","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.pharep.2016.06.005_bib0135","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ejphar.2014.11.023","article-title":"AM404 inhibits NFAT and NF-\u03baB signaling pathways and impairs migration and invasiveness of neuroblastoma cells","volume":"746","author":"Caballero","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharep.2016.06.005_bib0140","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neuropharm.2014.11.006","article-title":"Supra-spinal FAAH is required for the analgesic action of paracetamol in an inflammatory context","volume":"91","author":"Dalmann","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharep.2016.06.005_bib0145","doi-asserted-by":"crossref","first-page":"8829","DOI":"10.1523\/JNEUROSCI.1236-06.2006","article-title":"Endogenous cannabinoid signaling through the CB1 receptor is essential for cerebellum-dependent discrete motor learning","volume":"26","author":"Kishimoto","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharep.2016.06.005_bib0150","doi-asserted-by":"crossref","first-page":"4332","DOI":"10.1073\/pnas.92.10.4332","article-title":"Cannabinoid ligand-receptor signaling in the mouse uterus","volume":"92","author":"Das","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharep.2016.06.005_bib0155","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.neuron.2007.05.020","article-title":"Endocannabinoid-mediated long-term plasticity requires cAMP\/PKA signaling and RIM1\u03b1","volume":"54","author":"Chevaleyre","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.pharep.2016.06.005_bib0160","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1007\/s002100100484","article-title":"Effects of acetaminophen on monoaminergic systems in the rat central nervous system","volume":"364","author":"Courade","year":"2001","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.pharep.2016.06.005_bib0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(01)01464-9","article-title":"5-HT receptor subtypes involved in the spinal antinociceptive effect of acetaminophen in rats","volume":"432","author":"Courade","year":"2001","journal-title":"Eur J Pharmacol"},{"issue":"7","key":"10.1016\/j.pharep.2016.06.005_bib0170","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1177\/0269881107076369","article-title":"Effect of acetaminophen, a cyclooxygenase inhibitor, on Morris water maze task performance in mice","volume":"21","author":"Ishida","year":"2007","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.pharep.2016.06.005_bib0175","first-page":"802","article-title":"Effects of aspirin and paracetamol on ATPases of human fetal brain: an in vitro study","volume":"27","author":"Sarkar","year":"1989","journal-title":"Indian J Exp Biol"},{"key":"10.1016\/j.pharep.2016.06.005_bib0180","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s12311-013-0511-x","article-title":"Consensus paper: the cerebellum\u2019s role in movement and cognition","volume":"13","author":"Koziol","year":"2014","journal-title":"Cerebellum"},{"key":"10.1016\/j.pharep.2016.06.005_bib0185","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1476-069X-12-41","article-title":"Prenatal and perinatal analgesic exposure and autism: an ecological link","volume":"12","author":"Bauer","year":"2013","journal-title":"Environ Health"},{"key":"10.1016\/j.pharep.2016.06.005_bib0190","first-page":"642","article-title":"Acetaminophen in pregnancy and future risk of ADHD in offspring","volume":"60","author":"Blaser","year":"2014","journal-title":"Can Fam Phys"},{"key":"10.1016\/j.pharep.2016.06.005_bib0195","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/npp.2013.257","article-title":"Cerebellar morphology and the effects of stimulant medications in youths with attention deficit-hyperactivity disorder","volume":"39","author":"Ivanov","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharep.2016.06.005_bib0200","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/cne.902740105","article-title":"Early development of serotonin-containing neurons and pathways as seen in wholemount preparations of the fetal rat brain","volume":"274","author":"Aitken","year":"1988","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.pharep.2016.06.005_bib0205","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jchemneu.2013.12.004","article-title":"Distribution of serotonin 4(a) receptors in the juvenile rat brain and spinal cord","volume":"55","author":"Suwa","year":"2014","journal-title":"J Chem Neuroanat"},{"key":"10.1016\/j.pharep.2016.06.005_bib0210","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neuroscience.2013.05.029","article-title":"The role of serotonin in cerebellar development","volume":"248C","author":"Oostland","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharep.2016.06.005_bib0215","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1113\/jphysiol.2012.246413","article-title":"Serotonergic control of Purkinje cell maturation and climbing fibre elimination by 5-HT3 receptors in the juvenile mouse cerebellum","volume":"591","author":"Oostland","year":"2013","journal-title":"J Physiol"},{"key":"10.1016\/j.pharep.2016.06.005_bib0220","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ijpharm.2009.09.033","article-title":"MRP isoforms and BCRP mediate sulfate conjugate efflux out of BeWo cells","volume":"384","author":"Mitra","year":"2010","journal-title":"Int J Pharm"},{"key":"10.1016\/j.pharep.2016.06.005_bib0225","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jri.2012.10.014","article-title":"Acetaminophen and pregnancy: short- and long-term consequences for mother and child","volume":"97","author":"Thiele","year":"2013","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.pharep.2016.06.005_bib0230","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.bbr.2013.07.008","article-title":"Paracetamol-the outcome on neurotransmission and spatial learning in rats","volume":"253","author":"Blecharz-Klin","year":"2013","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pharep.2016.06.005_bib0235","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s11011-009-9143-8","article-title":"Brain creatine kinase activity is inhibited after hepatic failure induced by carbon tetrachloride or acetaminophen","volume":"24","author":"Pacheco","year":"2009","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.pharep.2016.06.005_bib0240","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.explore.2005.12.009","article-title":"Detoxification and biotransformational imbalances","volume":"2","author":"Liska","year":"2006","journal-title":"Explore"},{"key":"10.1016\/j.pharep.2016.06.005_bib0245","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.etap.2013.11.004","article-title":"Paracetamol impairs the profile of amino acids in the rat brain","volume":"37","author":"Blecharz-Klin","year":"2014","journal-title":"Environ Toxicol Pharmacol"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114016300718?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114016300718?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:36:34Z","timestamp":1752611794000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1016\/j.pharep.2016.06.005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S1734114016300718"],"URL":"https:\/\/doi.org\/10.1016\/j.pharep.2016.06.005","relation":{},"ISSN":["1734-1140"],"issn-type":[{"value":"1734-1140","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cerebellar level of neurotransmitters in rats exposed to paracetamol during development","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharep.2016.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Sp. z o.o. All rights reserved.","name":"copyright","label":"Copyright"}]}}