{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:21:39Z","timestamp":1793031699049,"version":"4.5.0"},"reference-count":101,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100010621","name":"Medical University of Lublin","doi-asserted-by":"crossref","award":["DS. 475\/16"],"award-info":[{"award-number":["DS. 475\/16"]}],"id":[{"id":"10.13039\/501100010621","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Reports"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.pharep.2016.06.011","type":"journal-article","created":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T12:45:12Z","timestamp":1473684312000},"page":"1084-1092","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":114,"title":["Epilepsy coexisting with depression"],"prefix":"10.1007","volume":"68","author":[{"given":"Barbara","family":"B\u0142aszczyk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanis\u0142aw J.","family":"Czuczwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"10.1016\/j.pharep.2016.06.011_bib0005","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/S0140-6736(14)60456-6","article-title":"Epilepsy: new advances","volume":"385","author":"Moshe","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.pharep.2016.06.011_bib0010","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.nbd.2009.11.001","article-title":"Comorbidity between epilepsy and depression: role of hippocampal interleukin-1\u03b2","volume":"37","author":"Mazarati","year":"2010","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.pharep.2016.06.011_bib0015","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.yebeh.2012.01.007","article-title":"Depression and epilepsy: epidemiologic and neurobiologic perspectives that may explain their high comorbid occurrence","volume":"24","author":"Kanner","year":"2012","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.pharep.2016.06.011_bib0020","series-title":"The Falling Sickness","author":"Temkin","year":"1950"},{"key":"10.1016\/j.pharep.2016.06.011_bib0025","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1017\/S0033291700013726","article-title":"Anticonvulsant drugs and mental symptoms: a review","volume":"6","author":"Trimble","year":"1976","journal-title":"Psychol Med"},{"key":"10.1016\/j.pharep.2016.06.011_bib0030","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-94-011-8123-5_3","article-title":"Anticonvulsant drugs, behavior, and cognitive abilities","volume":"6","author":"Trimble","year":"1981","journal-title":"Curr Dev Psychopharmacol"},{"issue":"4","key":"10.1016\/j.pharep.2016.06.011_bib0035","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1528-1157.1987.tb03659.x","article-title":"Phenomenology of depression in epilepsy","volume":"28","author":"Robertson","year":"1987","journal-title":"Epilepsia"},{"key":"10.1016\/j.pharep.2016.06.011_bib0040","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0165-0327(85)90091-6","article-title":"The treatment of depression in patients with epilepsy. A double-blind trial","volume":"9","author":"Robertson","year":"1985","journal-title":"J Affect Disord"},{"key":"10.1016\/j.pharep.2016.06.011_bib0045","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1001\/archpsyc.1977.01770220111013","article-title":"The family history metod using diagnostic criteria: reliability and validity","volume":"34","author":"Andreasen","year":"1977","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pharep.2016.06.011_bib0050","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1097\/00004583-199606000-00010","article-title":"Presentation and course of major depressive disorder Turing childhood and later years of the life span","volume":"35","author":"Kovacs","year":"1996","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"Suppl. 1","key":"10.1016\/j.pharep.2016.06.011_bib0055","doi-asserted-by":"crossref","first-page":"i45","DOI":"10.1136\/jnnp.2004.060467","article-title":"Depression and anxiety in epilepsy","volume":"76","author":"Jackson","year":"2005","journal-title":"J. Neurol. Neurosurg Psychiatry"},{"key":"10.1016\/j.pharep.2016.06.011_bib0060","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2165\/11599780-000000000-00000","article-title":"Beneficial and adverse effects of antiepileptic drugs in patients with epilepsy: a summary of prevalence, underlying mechanisms and data limitations","volume":"26","author":"Piedad","year":"2012","journal-title":"CNS Drugs"},{"key":"10.1016\/j.pharep.2016.06.011_bib0065","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1176\/ajp.153.1.57","article-title":"Psychodynamics and psychiatric diagnoses of pseudoseizure subjects","volume":"153","author":"Bowman","year":"1996","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharep.2016.06.011_bib0070","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1111\/j.1528-1167.2007.01222.x","article-title":"Psychiatric comorbidity in epilepsy: a population-based analysis","volume":"48","author":"Tellez-Zenteno","year":"2007","journal-title":"Epilepsia"},{"issue":"Suppl. 2","key":"10.1016\/j.pharep.2016.06.011_bib0075","first-page":"S3","article-title":"Co-morbid psychiatric disorder in chronic epilepsy: recognition and etiology of depression","volume":"53","author":"Wiegartz","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.pharep.2016.06.011_bib0080","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3109\/hrp.8.1.8","article-title":"Dysphoric disorders and paroxysmal affects: recognition and treatment of epilepsy-related psychiatric disorders","volume":"8","author":"Blumer","year":"2000","journal-title":"Harv Rev Psychiatry"},{"key":"10.1016\/j.pharep.2016.06.011_bib0085","series-title":"The Neuropsychiatry of Epilepsy","first-page":"80","article-title":"The interictal dysphoric disorder","author":"Mula","year":"2011"},{"key":"10.1016\/j.pharep.2016.06.011_bib0090","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1001\/archneur.1986.00520080014012","article-title":"Depression in epilepsy: significance and phenomenology","volume":"43","author":"Mendez","year":"1986","journal-title":"Arch Neurol"},{"key":"10.1016\/j.pharep.2016.06.011_bib0095","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1535-7511.2006.00125.x","article-title":"Depression and epilepsy: a new perspective on two closely related disorders","volume":"6","author":"Kanner","year":"2006","journal-title":"Epilepsy Curr"},{"key":"10.1016\/j.pharep.2016.06.011_bib0100","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1136\/jnnp.62.5.458","article-title":"Psychiatric profiles and patterns of cerebral blood flow in focal epilepsy: interactions between depression, obsessionality, and perfusion related to the laterality of the epilepsy","volume":"62","author":"Schmitz","year":"1997","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.pharep.2016.06.011_bib0105","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/S0006-3223(99)00212-7","article-title":"Amygdala enlargement in dysthymia\u2014a volumetric study of patients with temporal lobe epilepsy","volume":"46","author":"van Elst","year":"1999","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharep.2016.06.011_bib0110","series-title":"The Neuropsychiatry of Epilepsy","first-page":"241","article-title":"The effects of antiepileptic drugs on behavior","author":"Schmitz","year":"2002"},{"key":"10.1016\/j.pharep.2016.06.011_bib0115","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/1531-8249(200002)47:2<246::AID-ANA17>3.0.CO;2-E","article-title":"Major depression is a risk factor for seizures in older adults","volume":"47","author":"Hesdorffer","year":"2000","journal-title":"Ann Neurol"},{"key":"10.1016\/j.pharep.2016.06.011_bib0120","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.eplepsyres.2007.05.001","article-title":"Co-occurrence of major depression or suicide attempt with migraine with aura and risk forunprovoked seizure","volume":"75","author":"Hesdorffer","year":"2007","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.pharep.2016.06.011_bib0125","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/0920-1211(90)90010-S","article-title":"An incident case-referent study of epileptic seizures in adults","volume":"6","author":"Forsgren","year":"1990","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.pharep.2016.06.011_bib0130","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/ana.20685","article-title":"Depression and suicide attempt as risk factors for incident unprovoked seizures","volume":"59","author":"Hesdorffer","year":"2005","journal-title":"Ann Neurol"},{"key":"10.1016\/j.pharep.2016.06.011_bib0135","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.eplepsyres.2007.06.003","article-title":"Predictors of pharmacoresistant epilepsy","volume":"75","author":"Hitiris","year":"2007","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.pharep.2016.06.011_bib0140","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1212\/01.wnl.0000343850.85763.9c","article-title":"A lifetime psychiatric history predicts a worse seizure outcome following temporal lobectomy","volume":"72","author":"Kanner","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.pharep.2016.06.011_bib0145","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1111\/j.1528-1167.2007.01222.x","article-title":"Psychiatric comorbidity in epilepsy: a population-based analysis","volume":"48","author":"Tellez-Zenteno","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.pharep.2016.06.011_bib0150","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1111\/j.1471-4159.2007.04926.x","article-title":"Which clinical and experimental data link temporal lobe epilepsy with depression?","volume":"103","author":"Kondziella","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.pharep.2016.06.011_bib0155","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.2174\/138161209788168010","article-title":"Targeting glutamatergic signaling for the development of novel therapeutics for mood disorders","volume":"15","author":"Machado-Vieira","year":"2009","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.pharep.2016.06.011_bib0160","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1017\/S1092852900010403","article-title":"Beyond monoamines: glutamatergic function in mood disorders","volume":"10","author":"Kugaya","year":"2005","journal-title":"CNS Spectr"},{"key":"10.1016\/j.pharep.2016.06.011_bib0165","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/sj.mp.4001362","article-title":"GABAergic dysfunction in mood disorders","volume":"8","author":"Brambilla","year":"2003","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pharep.2016.06.011_bib0170","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00406-004-0499-9","article-title":"Impairment of inhibitory control of the hypothalamic pituitary adrenocortical system in epilepsy","volume":"254","author":"Zobel","year":"2004","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"10.1016\/j.pharep.2016.06.011_bib0175","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1212\/WNL.0b013e3181fc29dd","article-title":"Antiepileptic drug response in temporal lobe epilepsy: a clinical and MRI morphometry study","volume":"75","author":"Bilevicius","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.pharep.2016.06.011_bib0180","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1176\/appi.ajp.160.8.1516","article-title":"Untreated depression and hippocampal volume loss","volume":"160","author":"Sheline","year":"2003","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharep.2016.06.011_bib0185","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1176\/ajp.157.1.115","article-title":"Hippocampal volume reduction in major depression","volume":"157","author":"Bremner","year":"2000","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharep.2016.06.011_bib0190","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.yebeh.2014.06.027","article-title":"Is depression associated with an increased risk of treatment-resistant epilepsy: Research strategies to investigate this question","volume":"38","author":"Kanner","year":"2014","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.pharep.2016.06.011_bib0195","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.biopsych.2009.09.025","article-title":"Evidence of cortical inhibitory deficits in major depressive disorder","volume":"67","author":"Levinson","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharep.2016.06.011_bib0200","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/sj.ejhg.5201549","article-title":"Genetics of affective (mood) disorders","volume":"14","author":"Craddock","year":"2006","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.pharep.2016.06.011_bib0205","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/sj.mp.4002049","article-title":"CNTNAP2 gene dosage variation is associated with schizophrenia and epilepsy","volume":"13","author":"Friedman","year":"2008","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pharep.2016.06.011_bib0210","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1111\/j.1528-1167.2010.02677.x","article-title":"Evaluation of depression risk in LGI1 mutation carriers","volume":"51","author":"Heiman","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.pharep.2016.06.011_bib0215","first-page":"33","article-title":"Serotonin transporter gene\u00d7environment and risk of depression in community-treated epilepsy Epilepsy","volume":"39","author":"Lacey","year":"2014","journal-title":"Behav"},{"key":"10.1016\/j.pharep.2016.06.011_bib0220","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1055\/s-2008-1041211","article-title":"Psychic phenomena in partial seizures","volume":"11","author":"Devinsky","year":"1991","journal-title":"Semin Neurol"},{"key":"10.1016\/j.pharep.2016.06.011_bib0225","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/00005053-198608000-00005","article-title":"Mood change preceding epileptic seizures","volume":"174","author":"Blanchet","year":"1986","journal-title":"J Nerv Ment Dis"},{"issue":"Suppl. 10","key":"10.1016\/j.pharep.2016.06.011_bib0230","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1111\/j.1528-1157.1999.tb00884.x","article-title":"Depression in epilepsy: etiology, phenomenology,and treatment","volume":"40","author":"Lambert","year":"1999","journal-title":"Epilepsia"},{"key":"10.1016\/j.pharep.2016.06.011_bib0235","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1006\/ebeh.2000.0030","article-title":"Depression in epilepsy: a common but often unrecognized comorbid malady","volume":"1","author":"Kanner","year":"2000","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.pharep.2016.06.011_bib0240","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S1474-4422(06)70415-X","article-title":"Rapid detection of major depression in epilepsy: a multicentre study","volume":"5","author":"Gilliam","year":"2006","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.pharep.2016.06.011_bib0245","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1111\/j.1528-1167.2012.03571.x","article-title":"Screening for depression in epilepsy clinics: a comparison of conventional and visual-analog methods","volume":"53","author":"Rampling","year":"2012","journal-title":"Epilepsia"},{"key":"10.1016\/j.pharep.2016.06.011_bib0250","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.yebeh.2014.12.014","article-title":"Screening for depression in epilepsy: a model of an enhanced screening tool","volume":"44","author":"Drinovac","year":"2015","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.pharep.2016.06.011_bib0255","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.yebeh.2014.03.003","article-title":"Screening for depression in people with epilepsy: comparative study among Neurological Disorders Depression Inventory for Epilepsy (NDDI-E), Hospital Anxiety and Depression Scale Depression Subscale (HADS-D), and Beck Depression Inventory (BDI)","volume":"34","author":"de Oliveira","year":"2014","journal-title":"Epilepsy Behav"},{"issue":"Suppl. 20","key":"10.1016\/j.pharep.2016.06.011_bib0260","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interviewfor DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pharep.2016.06.011_bib0265","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S0006-3223(03)00469-4","article-title":"Depression in epilepsy: prevalence, clinical semiology, pathogenic mechanisms, and treatment","volume":"54","author":"Kanner","year":"2003","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharep.2016.06.011_bib0270","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1749-6632.1999.tb09278.x","article-title":"Prefrontal cortical networks related to visceral function and mood","volume":"877","author":"Price","year":"1999","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.pharep.2016.06.011_bib0275","first-page":"1128","article-title":"5-HT1A receptors are reduced in temporal lobe epilepsy after partial-volume correction","volume":"46","author":"Giovacchini","year":"2005","journal-title":"J Nucl Med"},{"key":"10.1016\/j.pharep.2016.06.011_bib0280","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1111\/j.1528-1167.2007.01089.x","article-title":"Reduced hippocampal 5HT1A PET receptor binding and depression in temporal lobe epilepsy","volume":"48","author":"Theodore","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.pharep.2016.06.011_bib0285","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.0013-9580.2004.452005.x","article-title":"Depression in epilepsy: ignoring clinical expression of neuronal network dysfunction?","volume":"45","author":"Gilliam","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.pharep.2016.06.011_bib0290","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1017\/S003329170003806X","article-title":"The anatomy of melancholia-focal abnormalities of cerebral blood flow in major depression","volume":"22","author":"Bench","year":"1992","journal-title":"Psychol Med"},{"key":"10.1016\/j.pharep.2016.06.011_bib0295","doi-asserted-by":"crossref","first-page":"3628","DOI":"10.1523\/JNEUROSCI.12-09-03628.1992","article-title":"A functional anatomical study of unipolar depression","volume":"12","author":"Drevets","year":"1992","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharep.2016.06.011_bib0300","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S1052-5149(03)00104-7","article-title":"Positron emission tomography imaging in depression: a neural systems perspective","volume":"13","author":"Mayberg","year":"2003","journal-title":"Neuroimaging Clin N Am"},{"key":"10.1016\/j.pharep.2016.06.011_bib0305","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0006-3223(96)00097-2","article-title":"Effect of sertraline on regional metabolic rate in patients with affective disorder","volume":"41","author":"Buchsbaum","year":"1997","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharep.2016.06.011_bib0310","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1037\/0033-2909.126.6.890","article-title":"Emotion, plasticity, context, and regulation: perspectives from affective neuroscience","volume":"126","author":"Davidson","year":"2000","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.pharep.2016.06.011_bib0315","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1136\/bmj.291.6487.2","article-title":"Epilepsy and employment","volume":"291","author":"Gloag","year":"1985","journal-title":"Br Med J"},{"issue":"1","key":"10.1016\/j.pharep.2016.06.011_bib0320","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/wps.20016","article-title":"Suicidal ideation and reported suicide attempts in Greece during the economic crisis","volume":"12","author":"Economou","year":"2013","journal-title":"World Psychiatry"},{"key":"10.1016\/j.pharep.2016.06.011_bib0325","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.yebeh.2010.08.029","article-title":"Depression in epilepsy is associated with lack of seizure control","volume":"19","author":"Dias","year":"2010","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.pharep.2016.06.011_bib0330","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1528-1157.1996.tb00006.x","article-title":"The clinical course of epilepsy and its psychosocial correlates: finding from a U.K. community study","volume":"37","author":"Jacoby","year":"1996","journal-title":"Epilepsia"},{"key":"10.1016\/j.pharep.2016.06.011_bib0335","first-page":"211","article-title":"Assessing the psychosocial consequences of epilepsy: a community-based study","volume":"49","author":"O\u2019Donoghue","year":"1999","journal-title":"Br J Gen Pract"},{"key":"10.1016\/j.pharep.2016.06.011_bib0340","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jpsychores.2005.04.001","article-title":"Do depression symptoms predict seizure frequency\u2014or vice versa?","volume":"59","author":"Thapar","year":"2005","journal-title":"J Psychosom Res"},{"key":"10.1016\/j.pharep.2016.06.011_bib0345","first-page":"83","article-title":"Depression in women with epilepsy: clinical and neurobiological aspects","volume":"24","author":"Cavanna","year":"2009","journal-title":"Funct Neurol"},{"key":"10.1016\/j.pharep.2016.06.011_bib0350","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s10597-011-9404-y","article-title":"Attitudes toward helpseeking and duration of untreated mental disorders in a sectorized Athens area of Greece","volume":"47","author":"Madianos","year":"2011","journal-title":"Commun Ment Health J"},{"key":"10.1016\/j.pharep.2016.06.011_bib0355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yebeh.2014.11.023","article-title":"Risk factors for depression in community-treated epilepsy: systematic review","volume":"43","author":"Lacey","year":"2015","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.pharep.2016.06.011_bib0360","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.yebeh.2007.06.004","article-title":"Psychological well-being of people with epilepsy in Norway","volume":"11","author":"Naess","year":"2007","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.pharep.2016.06.011_bib0365","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.yebeh.2008.09.004","article-title":"Stress, anxiety, depression, and epilepsy: investigating the relationship between psychological factors and seizures","volume":"14","author":"Thapar","year":"2009","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.pharep.2016.06.011_bib0370","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.yebeh.2005.09.014","article-title":"The presence and clinical implications of depression in a community population of adults with epilepsy","volume":"8","author":"Mensah","year":"2006","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.pharep.2016.06.011_bib0375","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1111\/j.1528-1167.2009.02386.x","article-title":"Psychiatric comorbidityand suicidal behavior in epilepsy: a community-based case\u2013control study","volume":"51","author":"Stefanello","year":"2010","journal-title":"Epilepsia"},{"issue":"Suppl. 1","key":"10.1016\/j.pharep.2016.06.011_bib0380","first-page":"1","article-title":"The treatment of depressive disorders in epilepsy: What all neurologists should know","volume":"54","author":"Kanner","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.pharep.2016.06.011_bib0385","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.yebeh.2009.05.007","article-title":"Determination of prevalence of depression in an epilepsy clinic using a brief DSM-IV-based self-report questionnaire","volume":"15","author":"Seminario","year":"2009","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.pharep.2016.06.011_bib0390","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.yebeh.2010.06.003","article-title":"PEARLS depression treatment for individuals with epilepsy: a randomized controlled trial","volume":"19","author":"Ciechanowski","year":"2010","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.pharep.2016.06.011_bib0395","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/nrneurol.2011.104","article-title":"Depression in epilepsy: a critical review from a clinical perspective","volume":"7","author":"Hoppe","year":"2011","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.pharep.2016.06.011_bib0400","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/00002826-200405000-00009","article-title":"Citalopram as treatment of depression in patients with epilepsy","volume":"27","author":"Specchio","year":"2004","journal-title":"Clin Neuropharmacol"},{"key":"10.1016\/j.pharep.2016.06.011_bib0405","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1097\/01.nrl.0000340788.07672.51","article-title":"Psychiatric comorbidities in epilepsy: identification and treatment","volume":"14","author":"Garcia-Morales","year":"2008","journal-title":"Neurologist"},{"key":"10.1016\/j.pharep.2016.06.011_bib0410","series-title":"Textbook of Psychopharmacology","first-page":"705","article-title":"Treatment of depression","author":"Charney","year":"1998"},{"key":"10.1016\/j.pharep.2016.06.011_bib0415","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1001\/archpsyc.63.8.856","article-title":"A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression","volume":"63","author":"Zarate","year":"2006","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pharep.2016.06.011_bib0420","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1017\/S0033291700033146","article-title":"Residual symptoms after partial remission; an important outcome in depression","volume":"25","author":"Paykel","year":"1995","journal-title":"Psychol Med"},{"key":"10.1016\/j.pharep.2016.06.011_bib0425","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.yebeh.2008.04.005","article-title":"Consensus statement: the evaluation and treatment of people with epilepsy and affective disorders","volume":"13","author":"Barry","year":"2008","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.pharep.2016.06.011_bib0430","first-page":"160","article-title":"Tricyclic antidepressant induced seizures and plasma drug concentration","volume":"53","author":"Preskorn","year":"1992","journal-title":"J Clin Psychol"},{"issue":"Suppl. 3","key":"10.1016\/j.pharep.2016.06.011_bib0435","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1016\/j.yebeh.2003.08.019","article-title":"Rates and risk factors for suicide, suicidal ideation, and suicide attempts in chronic epilepsy","volume":"4","author":"Jones","year":"2003","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.pharep.2016.06.011_bib0440","first-page":"909","article-title":"Phenobarbital treatment and major depressive disorder in children with epilepsy","volume":"80","author":"Brent","year":"1987","journal-title":"Pediatrics"},{"key":"10.1016\/j.pharep.2016.06.011_bib0445","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1212\/01.WNL.0000078031.32904.0D","article-title":"Psychiatric adverse events during levetiracetam therapy","volume":"61","author":"Mula","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.pharep.2016.06.011_bib0450","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.yebeh.2007.04.008","article-title":"Suicidal ideation in epilepsy and levetiracetam therapy","volume":"11","author":"Mula","year":"2007","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.pharep.2016.06.011_bib0455","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1111\/j.1528-1167.2008.01799.x","article-title":"The role of titration schedule of topiramate for the development of depression in patients with epilepsy","volume":"50","author":"Mula","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.pharep.2016.06.011_bib0460","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1111\/j.1528-1167.2011.03325.x","article-title":"Determinants of health-related quality of life in pharmacoresistant epilepsy: results from a large multicenter study of consecutively enrolled patients using validated quantitative assessments","volume":"52","author":"Luoni","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.pharep.2016.06.011_bib0465","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.yebeh.2004.01.010","article-title":"The impact of comorbid depression on health resource utilization in a community sample of people with epilepsy","volume":"5","author":"Cramer","year":"2004","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.pharep.2016.06.011_bib0470","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S1525-5050(03)00083-0","article-title":"Relationship between depression and intractability of seizures","volume":"4","author":"Attarian","year":"2003","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.pharep.2016.06.011_bib0475","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S1474-4422(07)70175-8","article-title":"Epilepsy and risk of suicide: a population-based case\u2013control study","volume":"6","author":"Christensen","year":"2007","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.pharep.2016.06.011_bib0480","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S1474-4422(06)70331-3","article-title":"Epilepsy, suicidal behaviour, and depression: do they share common pathogenic mechanisms?","volume":"5","author":"Kanner","year":"2006","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.pharep.2016.06.011_bib0485","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1016\/S0140-6736(13)60899-5","article-title":"Premature mortality in epilepsy and the role of psychiatric comorbidity: a total population study","volume":"382","author":"Fazel","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.pharep.2016.06.011_bib0490","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.neubiorev.2008.09.009","article-title":"Desperately driven and no brakes: developmental stress exposure and subsequent risk for substance abuse","volume":"33","author":"Andersen","year":"2009","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pharep.2016.06.011_bib0495","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.seizure.2013.11.012","article-title":"Utilization of care among drug resistant epilepsy patients with symptoms of anxiety and depression","volume":"23","author":"Hamilton","year":"2014","journal-title":"Seizure"},{"key":"10.1016\/j.pharep.2016.06.011_bib0500","series-title":"Antiepileptic Drugs: A Clinician\u2019s Manual","author":"Asadi-Pooya","year":"2009"},{"key":"10.1016\/j.pharep.2016.06.011_bib0505","series-title":"Depression in Neurological Disorders","author":"Kanner","year":"2005"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114016300779?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114016300779?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:36:34Z","timestamp":1752611794000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1016\/j.pharep.2016.06.011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":101,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S1734114016300779"],"URL":"https:\/\/doi.org\/10.1016\/j.pharep.2016.06.011","relation":{},"ISSN":["1734-1140"],"issn-type":[{"value":"1734-1140","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epilepsy coexisting with depression","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharep.2016.06.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Sp. z o.o. on behalf of Institute of Pharmacology, Polish Academy of Sciences.","name":"copyright","label":"Copyright"}]}}