{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T20:41:14Z","timestamp":1778964074005,"version":"3.51.4"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Medical University of Lublin, Poland","award":["DS 475\/16-SJC"],"award-info":[{"award-number":["DS 475\/16-SJC"]}]},{"name":"Medical University of Lublin, Poland","award":["DS 222\/14-JK"],"award-info":[{"award-number":["DS 222\/14-JK"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Reports"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.pharep.2016.09.006","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T13:58:04Z","timestamp":1473429484000},"page":"1345-1349","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Expression of Alzheimer\u2019s disease risk genes in ischemic brain degeneration"],"prefix":"10.1007","volume":"68","author":[{"given":"Marzena","family":"U\u0142amek-Kozio\u0142","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryszard","family":"Pluta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u0142awomir","family":"Januszewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janusz","family":"Kocki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Bogucka-Kocka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanis\u0142aw J.","family":"Czuczwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"10.1016\/j.pharep.2016.09.006_bib0005","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.pharep.2016.09.006_bib0010","doi-asserted-by":"crossref","first-page":"77sr1","DOI":"10.1126\/scitranslmed.3002369","article-title":"Alzheimer\u2019s disease: the challenge of the second century","volume":"3","author":"Holtzman","year":"2011","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.pharep.2016.09.006_bib0015","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.bbr.2011.01.009","article-title":"Impaired conditioned emotional response and object recognition are concomitant to neuronal damage in the amygdale and perirhinal cortex in middle-aged ischemic rats","volume":"219","author":"Barra de la Tremblaye","year":"2011","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pharep.2016.09.006_bib0020","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.lfs.2011.04.024","article-title":"Cerebral ischemia aggravates cognitive impairment in a rat model of Alzheimer\u2019s disease","volume":"89","author":"Li","year":"2011","journal-title":"Life Sci"},{"key":"10.1016\/j.pharep.2016.09.006_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2010.12.004","article-title":"Transient brain ischemia due to cardiac arrest causes irreversible long-lasting cognitive injury","volume":"219","author":"Kiryk","year":"2011","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pharep.2016.09.006_bib0030","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1749-6632.2000.tb06383.x","article-title":"The role of apolipoprotein E in the deposition of \u03b2-amyloid peptide during ischemia\u2013reperfusion brain injury. A model of early Alzheimer\u2019s disease","volume":"903","author":"Pluta","year":"2000","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.pharep.2016.09.006_bib0035","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1749-6632.2002.tb04803.x","article-title":"Astroglial expression of the beta-amyloid in ischemia\u2013reperfusion brain injury","volume":"977","author":"Pluta","year":"2002","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.pharep.2016.09.006_bib0040","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1002\/ar.21018","article-title":"Alzheimer\u2019s mechanisms in ischemic brain degeneration","volume":"92","author":"Pluta","year":"2009","journal-title":"Anat Rec"},{"key":"10.1016\/j.pharep.2016.09.006_bib0045","first-page":"101","article-title":"Postischemic dementia with Alzheimer phenotype: selectively vulnerable versus resistant areas of the brain and neurodegeneration versus \u03b2-amyloid peptide","volume":"50","author":"Pluta","year":"2012","journal-title":"Folia Neuropathol"},{"issue":"Suppl","key":"10.1016\/j.pharep.2016.09.006_bib0050","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/3-211-30714-1_57","article-title":"Micro-blood\u2013brain barrier openings and cytotoxic fragments of amyloid precursor protein accumulation in white matter after ischemic brain injury in long-lived rats","volume":"96","author":"Pluta","year":"2006","journal-title":"Acta Neurochir"},{"issue":"Suppl","key":"10.1016\/j.pharep.2016.09.006_bib0055","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/978-3-211-85578-2_67","article-title":"Ischemic blood\u2013brain barrier and amyloid in white matter as etiological factors in leukoaraiosis","volume":"102","author":"Pluta","year":"2008","journal-title":"Acta Neurochir"},{"key":"10.1016\/j.pharep.2016.09.006_bib0060","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00429-011-0336-7","article-title":"Cellular markers of neuroinflammation and neurogenesis after ischemic brain injury in the long-term survival rat model","volume":"217","author":"Sekeljic","year":"2012","journal-title":"Brain Struct Funct"},{"key":"10.1016\/j.pharep.2016.09.006_bib0065","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0006-8993(94)91081-2","article-title":"Complete cerebral ischemia with shortterm survival in rats induced by cardiac arrest: I. Extracellular accumulation of Alzheimer\u2019s \u03b2-amyloid protein precursor in the brain","volume":"649","author":"Pluta","year":"1994","journal-title":"Brain Res"},{"key":"10.1016\/j.pharep.2016.09.006_bib0070","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0006-8993(94)01467-V","article-title":"Complete cerebral ischemia with short-term survival in rat induced by cardiac arrest: II. Extracellular and intracellular accumulation of apolipoproteins E and J in the brain","volume":"674","author":"Kida","year":"1995","journal-title":"Brain Res"},{"key":"10.1016\/j.pharep.2016.09.006_bib0075","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0006-8993(98)00033-X","article-title":"Changes in presynaptic protein NACP\/alpha-synuclein in an ischemic gerbil hippocampus","volume":"788","author":"Ishimaru","year":"1998","journal-title":"Brain Res"},{"issue":"Suppl. 1","key":"10.1016\/j.pharep.2016.09.006_bib0080","first-page":"S424","article-title":"Proteins associated with Alzheimer\u2019s disease in conditions predisposing to Alzheimer\u2019s-type neurodegeneration","volume":"21","author":"Pluta","year":"2001","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.pharep.2016.09.006_bib0085","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.bbadis.2006.10.011","article-title":"Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats","volume":"1772","author":"Wen","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.pharep.2016.09.006_bib0090","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/BF00294806","article-title":"Ischemic stress induces deposition of amyloid beta immunoreactivity in human brain","volume":"90","author":"Jendroska","year":"1995","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.pharep.2016.09.006_bib0095","first-page":"65","article-title":"Beta-protein immunoreactivity in the human brain after cardiac arrest","volume":"34","author":"Wi\u015bniewski","year":"1996","journal-title":"Folia Neuropathol"},{"key":"10.1016\/j.pharep.2016.09.006_bib0100","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1749-6632.1997.tb48492.x","article-title":"\u03b2 peptide and precursor protein (APP) in mild and severe brain ischemia","volume":"826","author":"Jendroska","year":"1997","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.pharep.2016.09.006_bib0105","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3233\/JAD-2007-12406","article-title":"Cerebral ischemia and Alzheimer\u2019s disease: the expression of amyloid-\u03b2 and apolipoprotein E in human hippocampus","volume":"12","author":"Qi","year":"2007","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.pharep.2016.09.006_bib0110","first-page":"295","article-title":"Immunodistribution of amyloid beta protein (A\u03b2) and advanced glycation end-product receptors (RAGE) in choroid plexus and ependyma of resuscitated patients","volume":"49","author":"Ma\u015bli\u0144ska","year":"2011","journal-title":"Folia Neuropathol"},{"key":"10.1016\/j.pharep.2016.09.006_bib0115","first-page":"94","article-title":"Experimental model of neuropathological changes characteristic for Alzheimer\u2019s disease","volume":"35","author":"Pluta","year":"1997","journal-title":"Folia Neuropathol"},{"key":"10.1016\/j.pharep.2016.09.006_bib0120","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1097\/00001756-199802160-00029","article-title":"Post-ischemic changes in the expression of Alzheimer\u2019s APP isoforms in rat cerebral cortex","volume":"9","author":"Kim","year":"1998","journal-title":"Neuroreport"},{"key":"10.1016\/j.pharep.2016.09.006_bib0125","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0006-8993(98)00888-9","article-title":"Estrogen attenuates over-expression of beta-amyloid precursor protein messenger RNA in an animal model of focal ischemia","volume":"810","author":"Shi","year":"1998","journal-title":"Brain Res"},{"key":"10.1016\/j.pharep.2016.09.006_bib0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(99)02113-7","article-title":"Hypoperfusion induces overexpression of \u03b2-amyloid precursor protein mRNA in a focal ischemic rodent model","volume":"853","author":"Shi","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.pharep.2016.09.006_bib0135","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0304-3940(91)90020-T","article-title":"Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex","volume":"125","author":"Abe","year":"1991","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pharep.2016.09.006_bib0140","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1097\/00001756-199611040-00064","article-title":"Expression of \u03b2-amyloid precursor protein mRNAs following transient focal ischaemia","volume":"7","author":"Koistinaho","year":"1996","journal-title":"NeuroReport"},{"key":"10.1016\/j.pharep.2016.09.006_bib0145","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.3233\/JAD-150299","article-title":"Dysregulation of amyloid precursor protein, \u03b2-secretase, presenilin 1 and 2 genes in the rat selectively vulnerable CA1 subfield of hippocampus following transient global brain ischemia","volume":"47","author":"Kocki","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.pharep.2016.09.006_bib0150","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.3233\/JAD-151102","article-title":"Discrepancy in expression of \u03b2-secretase and amyloid-\u03b2 protein precursor in Alzheimer-related genes in the rat medial temporal lobe cortex following transient global brain ischemia","volume":"51","author":"Pluta","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.pharep.2016.09.006_bib0155","first-page":"2515","article-title":"mRNA expression and activity of ADAM17 in hippocampus after chronic cerebral hypoperfusion: experiment with aged rats","volume":"87","author":"Yan","year":"2007","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"10.1016\/j.pharep.2016.09.006_bib0160","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s12035-012-8360-z","article-title":"Brain ischemia activates \u03b2- and \u03b3-secretase cleavage of amyloid precursor protein: significance in sporadic Alzheimer\u2019s disease","volume":"47","author":"Pluta","year":"2013","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.pharep.2016.09.006_bib0165","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1097\/WNR.0b013e328332024a","article-title":"Alterations in mRNA expression of BACE1, cathepsin B, and glutaminyl cyclase in mice ischemic brain","volume":"20","author":"Ye","year":"2009","journal-title":"Neuroreport"},{"key":"10.1016\/j.pharep.2016.09.006_bib0170","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/19077","article-title":"Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity","volume":"398","author":"Wolfe","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.pharep.2016.09.006_bib0175","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/embo-reports\/kve180","article-title":"Presenilin-dependent gamma secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch","volume":"2","author":"Sastre","year":"2001","journal-title":"EMBO Rep"},{"key":"10.1016\/j.pharep.2016.09.006_bib0180","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.2353\/ajpath.2008.070975","article-title":"Regulated intramembrane proteolysis of the low-density lipoprotein receptor-related protein mediates ischemic cell death","volume":"172","author":"Polavarapu","year":"2008","journal-title":"Am J Pathol"},{"key":"10.1016\/j.pharep.2016.09.006_bib0185","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/S0169-328X(97)00337-9","article-title":"Alzheimer-associated presenilin-1 gene is induced in gerbil hippocampus after transient ischemia","volume":"54","author":"Tanimukai","year":"1998","journal-title":"Mol Brain Res"},{"key":"10.1016\/j.pharep.2016.09.006_bib0190","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0361-9230(99)00031-3","article-title":"Induction of presenilins in the rat brain after middle cerebral arterial occlusion","volume":"48","author":"Pennypacker","year":"1999","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.pharep.2016.09.006_bib0195","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.pharep.2015.08.002","article-title":"Alzheimer-associated presenilin 2 gene is dysregulated in rat medial temporal lobe cortex after complete brain ischemia due to cardiac arrest","volume":"68","author":"Pluta","year":"2016","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.pharep.2016.09.006_bib0200","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3233\/JAD-160387","article-title":"Dysregulation of autophagy, mitophagy and apoptotic genes in the medial temporal lobe cortex in an ischemic model of Alzheimer\u2019s disease","volume":"54","author":"U\u0142amek-Kozio\u0142","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.pharep.2016.09.006_bib0205","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0022-510X(87)90130-4","article-title":"Recovery of integrative central nervous function after one hour global cerebro-circulatory arrest in normothermic cat","volume":"77","author":"Hossmann","year":"1987","journal-title":"J Neurol Sci"},{"issue":"Suppl. 1","key":"10.1016\/j.pharep.2016.09.006_bib0210","doi-asserted-by":"crossref","first-page":"S113","DOI":"10.33549\/physiolres.932186","article-title":"One year follow up in ischemic brain injury and the role of Alzheimer factors","volume":"60","author":"Jab\u0142o\u0144ski","year":"2011","journal-title":"Physiol Res"},{"key":"10.1016\/j.pharep.2016.09.006_bib0215","doi-asserted-by":"crossref","first-page":"322","DOI":"10.5114\/fn.2012.32362","article-title":"Ischemia signaling to Alzheimer-related genes","volume":"50","author":"Pluta","year":"2012","journal-title":"Folia Neuropathol"},{"key":"10.1016\/j.pharep.2016.09.006_bib0220","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/s12035-013-8439-1","article-title":"Sporadic Alzheimer\u2019s disease begins as episodes of brain ischemia and ischemically dysregulated Alzheimer\u2019s disease genes","volume":"48","author":"Pluta","year":"2013","journal-title":"Mol Neurobiol"},{"issue":"Suppl","key":"10.1016\/j.pharep.2016.09.006_bib0225","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/3-211-30714-1_64","article-title":"Long-term cognitive and neuropsychological symptoms after global cerebral ischemia in Mongolian gerbils","volume":"96","author":"Ishibashi","year":"2006","journal-title":"Acta Neurochir"},{"issue":"5","key":"10.1016\/j.pharep.2016.09.006_bib0230","doi-asserted-by":"crossref","first-page":"e0124918","DOI":"10.1371\/journal.pone.0124918","article-title":"Effect of cardiac arrest on cognitive impairment and hippocampal plasticity in middle-aged rats","volume":"10","author":"Cohan","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.pharep.2016.09.006_bib0235","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.pharep.2016.01.006","article-title":"Brain ischemia with Alzheimer phenotype dysregulates Alzheimer\u2019s disease-related proteins","volume":"68","author":"U\u0142amek-Kozio\u0142","year":"2016","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.pharep.2016.09.006_bib0240","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000003089","article-title":"Late-onset depressive symptoms increase the risk of dementia in small vessel disease","author":"van Uden","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.pharep.2016.09.006_bib0245","doi-asserted-by":"crossref","first-page":"c3666","DOI":"10.1136\/bmj.c3666","article-title":"The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis","volume":"341","author":"Debette","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.pharep.2016.09.006_bib0250","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1111\/nan.12116","article-title":"Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke","volume":"40","author":"Bailey","year":"2014","journal-title":"Neuropathol Appl Neurobiol"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114016301505?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114016301505?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:36:40Z","timestamp":1752611800000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1016\/j.pharep.2016.09.006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S1734114016301505"],"URL":"https:\/\/doi.org\/10.1016\/j.pharep.2016.09.006","relation":{},"ISSN":["1734-1140"],"issn-type":[{"value":"1734-1140","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression of Alzheimer\u2019s disease risk genes in ischemic brain degeneration","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharep.2016.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Sp. z o.o. All rights reserved.","name":"copyright","label":"Copyright"}]}}