{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T16:37:35Z","timestamp":1784911055521,"version":"3.55.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Science & Engineering Board (SERB)"},{"name":"Department of Science and Technology, Govt. of India New Delhi"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Reports"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.pharep.2016.11.008","type":"journal-article","created":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T15:02:58Z","timestamp":1479481378000},"page":"306-313","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Sertraline and venlafaxine improves motor performance and neurobehavioral deficit in quinolinic acid induced Huntington\u2019s like symptoms in rats: Possible neurotransmitters modulation"],"prefix":"10.1007","volume":"69","author":[{"given":"Jaskamal Singh","family":"Gill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Jamwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puneet","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Deshmukh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"issue":"1","key":"10.1016\/j.pharep.2016.11.008_bib0005","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.expneurol.2007.10.015","article-title":"The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6\/2 Huntington\u2019s disease mouse model","volume":"210","author":"Peng","year":"2008","journal-title":"Exp Neurol"},{"issue":"2014","key":"10.1016\/j.pharep.2016.11.008_bib0010","first-page":"9","article-title":"The 3\u2010NP model of striatal neurodegeneration","volume":"10","author":"Brouillet","year":"2014","journal-title":"Curr Protoc Neurosci"},{"issue":"2","key":"10.1016\/j.pharep.2016.11.008_bib0015","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.pathophys.2016.03.002","article-title":"Beneficial effect of antidepressants against rotenone induced Parkinsonism like symptoms in rats","volume":"23","author":"Sharma","year":"2016","journal-title":"Pathophysiology"},{"issue":"1","key":"10.1016\/j.pharep.2016.11.008_bib0020","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1750-3639.1999.tb00216.x","article-title":"Oxidative stress in Huntington's disease","volume":"9","author":"Browne","year":"1999","journal-title":"Brain Pathol"},{"issue":"2","key":"10.1016\/j.pharep.2016.11.008_bib0025","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuron.2010.01.008","article-title":"Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington\u2019s disease mice","volume":"65","author":"Milnerwood","year":"2010","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.pharep.2016.11.008_bib0030","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejphar.2007.05.002","article-title":"Possible involvement of L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway in the antidepressant activity of berberine chloride","volume":"569","author":"Kulkarni","year":"2007","journal-title":"Eur J Pharmacol"},{"issue":"6","key":"10.1016\/j.pharep.2016.11.008_bib0035","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1517\/13543780902880850","article-title":"Current investigational drugs for major depression","volume":"18","author":"Kulkarni","year":"2009","journal-title":"Expert Opin Investig Drugs"},{"issue":"1-2","key":"10.1016\/j.pharep.2016.11.008_bib0040","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1385\/JMN:14:1-2:027","article-title":"Expression of neurotrophins BDNF and NT-3, and their receptors in rat brain after administration of antipsychotic and psychotrophic agents","volume":"14","author":"Lind\u00e9n","year":"2000","journal-title":"J Mol Neurosci"},{"issue":"3","key":"10.1016\/j.pharep.2016.11.008_bib0045","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.nbd.2008.01.015","article-title":"Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease","volume":"30","author":"Duan","year":"2008","journal-title":"Neurobiol Dis"},{"issue":"3","key":"10.1016\/j.pharep.2016.11.008_bib0050","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1089\/jmf.2008.0028","article-title":"Possible neuroprotective effect of Withania somnifera root extract against 3-nitropropionic acid-induced behavioral, biochemical, and mitochondrial dysfunction in an animal model of Huntington's disease","volume":"12","author":"Kumar","year":"2009","journal-title":"J Med Food"},{"issue":"3","key":"10.1016\/j.pharep.2016.11.008_bib0055","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s11064-006-9258-9","article-title":"Venlafaxine modulates depression-induced oxidative stress in brain and medulla of rat","volume":"32","author":"Eren","year":"2007","journal-title":"Neurochem Res"},{"issue":"3","key":"10.1016\/j.pharep.2016.11.008_bib0060","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1139\/y86-060","article-title":"The neurotoxic actions of quinolinic acid in the central nervous system","volume":"64","author":"El-Defrawy","year":"1986","journal-title":"Can J Physiol Pharmacol"},{"issue":"2\u20133","key":"10.1016\/j.pharep.2016.11.008_bib0065","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF03033790","article-title":"Excitotoxicity of quinolinic acid: modulation by endogenous antagonists","volume":"2","author":"Jhamandas","year":"2000","journal-title":"Neurotox Res"},{"issue":"4","key":"10.1016\/j.pharep.2016.11.008_bib0070","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s12640-012-9315-x","article-title":"Targeting neuro-inflammatory cytokines and oxidative stress by minocycline attenuates quinolinic-acid-induced Huntington\u2019s disease-like symptoms in rats","volume":"22","author":"Kalonia","year":"2012","journal-title":"Neurotox Res"},{"issue":"4","key":"10.1016\/j.pharep.2016.11.008_bib0075","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s12640-014-9469-9","article-title":"Improvement of mitochondrial function by paliperidone attenuates quinolinic acid-induced behavioural and neurochemical alterations in rats: implications in Huntington\u2019s disease","volume":"26","author":"Mishra","year":"2014","journal-title":"Neurotox Res"},{"issue":"2","key":"10.1016\/j.pharep.2016.11.008_bib0080","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s12640-015-9535-y","article-title":"Protective effect of spermidine against excitotoxic neuronal death induced by quinolinic acid in rats: possible neurotransmitters and neuroinflammatory mechanism","volume":"28","author":"Jamwal","year":"2015","journal-title":"Neurotox Res"},{"issue":"9","key":"10.1016\/j.pharep.2016.11.008_bib0085","doi-asserted-by":"crossref","first-page":"673","DOI":"10.3109\/00207454.2013.872642","article-title":"Neuroprotective activity of L-theanine on 3-nitropropionic acid-induced neurotoxicity in rat striatum","volume":"124","author":"Thangarajan","year":"2014","journal-title":"Int J Neurosci"},{"issue":"10","key":"10.1016\/j.pharep.2016.11.008_bib0090","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1177\/0269881110364269","article-title":"Novel protective mechanisms of antidepressants against 3-nitropropionic acid induced Huntington\u2019s-like symptoms: a comparative study","volume":"25","author":"Kumar","year":"2011","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.pharep.2016.11.008_bib0095","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neuroscience.2014.12.018","article-title":"Neuroprotective effect of hemeoxygenase-1\/glycogen synthase kinase-3\u03b2 modulators in 3-nitropropionic acid-induced neurotoxicity in rats","volume":"287","author":"Khan","year":"2015","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.pharep.2016.11.008_bib0100","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1042\/bj0990667","article-title":"Mechanisms of lipid peroxide formation in animal tissues","volume":"99","author":"Wills","year":"1966","journal-title":"Biochem J"},{"issue":"1","key":"10.1016\/j.pharep.2016.11.008_bib0105","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal Biochem"},{"issue":"1","key":"10.1016\/j.pharep.2016.11.008_bib0110","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch Biochem Biophys"},{"issue":"1","key":"10.1016\/j.pharep.2016.11.008_bib0115","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.pharep.2016.11.008_bib0120","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0304-3940(84)90050-8","article-title":"Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid","volume":"48","author":"Foster","year":"1984","journal-title":"Neurosci Lett"},{"issue":"4","key":"10.1016\/j.pharep.2016.11.008_bib0125","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/ilar.48.4.356","article-title":"Animal models of Huntington\u2019s disease","volume":"48","author":"Ramaswamy","year":"2007","journal-title":"ILAR J"},{"issue":"2013","key":"10.1016\/j.pharep.2016.11.008_bib0130","first-page":"114","article-title":"Dopamine imbalance in Huntington\u2019s disease: a mechanism for the lack of behavioral flexibility","volume":"7","author":"Chen","year":"2013","journal-title":"Front Neurosci"},{"issue":"1","key":"10.1016\/j.pharep.2016.11.008_bib0135","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1093\/brain\/awl332","article-title":"The fate of striatal dopaminergic neurons in Parkinson's disease and Huntington\u2019s chorea","volume":"130","author":"Huot","year":"2007","journal-title":"Brain"},{"issue":"3","key":"10.1016\/j.pharep.2016.11.008_bib0140","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1001\/archpsyc.64.3.327","article-title":"The role of dopamine in the pathophysiology of depression","volume":"64","author":"Dunlop","year":"2007","journal-title":"Arch Gen Psychiatry"},{"issue":"1","key":"10.1016\/j.pharep.2016.11.008_bib0145","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ejphar.2010.08.026","article-title":"Sertraline increases extracellular levels not only of serotonin, but also of dopamine in the nucleus accumbens and striatum of rats","volume":"647","author":"Kitaichi","year":"2010","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"10.1016\/j.pharep.2016.11.008_bib0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s002130050638","article-title":"Dose-dependent noradrenergic and serotonergic properties of venlafaxine in animal models indicative of antidepressant activity","volume":"138","author":"Redrobe","year":"1998","journal-title":"Psychopharmacology (Berl)"},{"issue":"12","key":"10.1016\/j.pharep.2016.11.008_bib0155","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.biopsych.2012.11.009","article-title":"The action of antidepressants on the glutamate system: regulation of glutamate release and glutamate receptors","volume":"73","author":"Musazzi","year":"2013","journal-title":"Biol Psychiatry"},{"issue":"8","key":"10.1016\/j.pharep.2016.11.008_bib0160","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.bcp.2004.07.027","article-title":"Effect of antidepressants on GABA B receptor function and subunit expression in rat hippocampus","volume":"68","author":"Sands","year":"2004","journal-title":"Biochem Pharmacol"},{"issue":"6203","key":"10.1016\/j.pharep.2016.11.008_bib0165","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1126\/science.1250469","article-title":"GABA\/glutamate co-release controls habenula output and is modified by antidepressant treatment","volume":"345","author":"Shabel","year":"2014","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.pharep.2016.11.008_bib0170","doi-asserted-by":"crossref","first-page":"7539","DOI":"10.1523\/JNEUROSCI.15-11-07539.1995","article-title":"Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments","volume":"15","author":"Nibuya","year":"1995","journal-title":"J Neurosci"},{"issue":"7","key":"10.1016\/j.pharep.2016.11.008_bib0175","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1523\/JNEUROSCI.16-07-02365.1996","article-title":"Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus","volume":"16","author":"Nibuya","year":"1996","journal-title":"J Neurosci"},{"issue":"4","key":"10.1016\/j.pharep.2016.11.008_bib0180","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1007\/s00415-009-5357-2","article-title":"Serum levels of brain-derived neurotrophic factor correlate with motor impairment in Parkinson\u2019s disease","volume":"257","author":"Scalzo","year":"2010","journal-title":"J Neurol"},{"issue":"2015","key":"10.1016\/j.pharep.2016.11.008_bib0185","first-page":"130","article-title":"A pilot study on the effect of cognitive training on BDNF serum levels in individuals with Parkinson\u2019s disease","volume":"9","author":"Angelucci","year":"2015","journal-title":"Front Hum Neurosci"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114016303796?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114016303796?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:36:48Z","timestamp":1752611808000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1016\/j.pharep.2016.11.008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S1734114016303796"],"URL":"https:\/\/doi.org\/10.1016\/j.pharep.2016.11.008","relation":{},"ISSN":["1734-1140"],"issn-type":[{"value":"1734-1140","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sertraline and venlafaxine improves motor performance and neurobehavioral deficit in quinolinic acid induced Huntington\u2019s like symptoms in rats: Possible neurotransmitters modulation","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharep.2016.11.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Sp. z o.o. on behalf of Institute of Pharmacology, Polish Academy of Sciences.","name":"copyright","label":"Copyright"}]}}