{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:09:35Z","timestamp":1791461375729,"version":"4.3.4"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Reports"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.pharep.2016.12.004","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T17:00:55Z","timestamp":1481302855000},"page":"358-364","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Telmisartan attenuates diabetes induced depression in rats"],"prefix":"10.1007","volume":"69","author":[{"given":"Urmila","family":"Aswar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpa","family":"Chepurwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Shintre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Aswar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"10.1016\/j.pharep.2016.12.004_bib0005","first-page":"42","article-title":"Depressed diabetics: a neuroimmunologic syndrome","volume":"12","author":"Sabharwal","year":"2005","journal-title":"Prim Psychiatry"},{"key":"10.1016\/j.pharep.2016.12.004_bib0010","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.diabres.2010.01.024","article-title":"Diabetes and depression: global perspectives","volume":"87","author":"Egede","year":"2010","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.pharep.2016.12.004_bib0015","doi-asserted-by":"crossref","first-page":"112","DOI":"10.2174\/157339909788166828","article-title":"Depression and quality of life in patients with diabetes: a systematic review from the European depression in diabetes (EDID) research consortium","volume":"5","author":"Schram","year":"2009","journal-title":"Curr Diabetes Rev"},{"key":"10.1016\/j.pharep.2016.12.004_bib0020","doi-asserted-by":"crossref","first-page":"e57058","DOI":"10.1371\/journal.pone.0057058","article-title":"Depression and risk of mortality in people with diabetes mellitus: a systematic review and meta-analysis","volume":"8","author":"van Dooren","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.pharep.2016.12.004_bib0025","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s10571-011-9754-6","article-title":"Angiotensin II AT1 receptor blockers ameliorate inflammatory stress: a beneficial effect for the treatment of brain disorders","volume":"32","author":"Saavedra","year":"2012","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.pharep.2016.12.004_bib0030","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/10253890701350735","article-title":"Brain and peripheral angiotensin II play a major role in stress","volume":"10","author":"Saavedra","year":"2007","journal-title":"Stress"},{"key":"10.1016\/j.pharep.2016.12.004_bib0035","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/j.1472-8206.2009.00780.x","article-title":"The evolving story of the RAAS in hypertension, diabetes and CV disease-moving from macrovascular to microvascular targets","volume":"23","author":"Steckelings","year":"2009","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1016\/j.pharep.2016.12.004_bib0040","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.tem.2005.02.003","article-title":"The renin-angiotensin-aldosterone system, glucose metabolism and diabetes","volume":"16","author":"Giacchetti","year":"2005","journal-title":"Trends Endocrin Met"},{"key":"10.1016\/j.pharep.2016.12.004_bib0045","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/08037050600771583","article-title":"Findings and implications of the study of cognition and prognosis in the elderly (SCOPE)\u2014a review","volume":"15","author":"Zanchetti","year":"2006","journal-title":"Blood Press"},{"key":"10.1016\/j.pharep.2016.12.004_bib0050","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s10571-011-9656-7","article-title":"Lower frequency of antidepressant use in patients on renin-angiotensin-aldosterone system modifying medications","volume":"31","author":"Nasr","year":"2011","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.pharep.2016.12.004_bib0055","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1080\/10253890701476621","article-title":"Chronic administration of an angiotensin II receptor antagonist resets the hypothalamus-pituitary-adrenal (HPA) axis and improves the effect of patients with diabetes mellitus type 2: preliminary results","volume":"11","author":"Pavlatou","year":"2008","journal-title":"Stress"},{"key":"10.1016\/j.pharep.2016.12.004_bib0060","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.brainres.2012.03.021","article-title":"Role of angiotensin II in the brain inflammatory events during experimental diabetes in rats","volume":"1453","author":"Vargas","year":"2012","journal-title":"Brain Res"},{"key":"10.1016\/j.pharep.2016.12.004_bib0065","first-page":"23","article-title":"Angiotensin II, via angiotensin receptor type 1\/nuclear factor-\u03baB activation, causes a synergistic effect on interleukin-1\u03b2 induced inflammatory responses in cultured mesangial cells","volume":"16","author":"Alique","year":"2015","journal-title":"JRAAS"},{"key":"10.1016\/j.pharep.2016.12.004_bib0070","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.pnpbp.2010.06.014","article-title":"Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression","volume":"35","author":"Maes","year":"2011","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pharep.2016.12.004_bib0075","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.biopsych.2008.11.029","article-title":"Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression","volume":"65","author":"Miller","year":"2009","journal-title":"Biol Psychiatry"},{"issue":"4","key":"10.1016\/j.pharep.2016.12.004_bib0080","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/00005344-200304000-00012","article-title":"Central nervous system blockade by peripheral administration of AT1 receptor blockers","volume":"41","author":"Wang","year":"2003","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.pharep.2016.12.004_bib0085","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/npp.2010.225","article-title":"Angiotensin II AT1 receptor blockade ameliorates brain inflammation","volume":"36","author":"Benicky","year":"2011","journal-title":"Neuropsychopharmacol"},{"issue":"6\u20137","key":"10.1016\/j.pharep.2016.12.004_bib0090","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s10571-009-9368-4","article-title":"Anti-inflammatory effects of angiotensin receptor blockers in the brain and the periphery","volume":"29","author":"Benicky","year":"2009","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.pharep.2016.12.004_bib0095","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.pbb.2015.08.007","article-title":"Telmisartan mediates anti-inflammatory and not cognitive function through PPAR-\u03b3 agonism via SARM and MyD88 signaling","volume":"137","author":"Balaji","year":"2015","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pharep.2016.12.004_bib0100","doi-asserted-by":"crossref","first-page":"413","DOI":"10.5567\/pharmacologia.2012.413.419","article-title":"Antidepressant activity of Karnim in diabetes associated depression in experimental animals","volume":"3","author":"Somani","year":"2012","journal-title":"Pharmacologia"},{"issue":"4","key":"10.1016\/j.pharep.2016.12.004_bib0105","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/BF00437510","article-title":"Effects of antidepressant agents on open field behaviour in rats","volume":"33","author":"Kulkarni","year":"1973","journal-title":"Psychopharmacologia"},{"issue":"1","key":"10.1016\/j.pharep.2016.12.004_bib0110","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1177\/000456326900600108","article-title":"Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor","volume":"6","author":"Trinder","year":"1969","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/j.pharep.2016.12.004_bib0115","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal Biochem"},{"key":"10.1016\/j.pharep.2016.12.004_bib0120","first-page":"640","article-title":"with complications of type 2 diabetes-the Chennai urban, rural epidemiology study (CURES-102)","volume":"59","author":"Poongothai","year":"2011","journal-title":"J Assoc Physicians India"},{"key":"10.1016\/j.pharep.2016.12.004_bib0125","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.brainres.2007.03.088","article-title":"Oxidative stress parameters in diabetic rats submitted to forced swimming test: the clonazepam effect","volume":"1154","author":"Haeser","year":"2007","journal-title":"Brain Res"},{"key":"10.1016\/j.pharep.2016.12.004_bib0130","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.neubiorev.2011.10.001","article-title":"Depression and type 2 diabetes: inflammatory mechanisms of a psychoneuroendocrine co-morbidity","volume":"36","author":"Stuart","year":"2012","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pharep.2016.12.004_bib0135","first-page":"124","article-title":"Attenuating effect of lisinopril and telmisartan in intracerebroventricular streptozotocin induced experimental dementia of Alzheimer\u2019s disease type: possible involvement of PPAR-\u03b3 agonistic property","volume":"14","author":"Singh","year":"2013","journal-title":"JRAAS"},{"issue":"2","key":"10.1016\/j.pharep.2016.12.004_bib0140","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3923\/jpt.2012.87.95","article-title":"Depression like effect of telmisartan in mice forced swim test: involvement of brain monoaminergic system","volume":"7","author":"Vijayapandi","year":"2012","journal-title":"J Pharmacol Toxicol"},{"issue":"3","key":"10.1016\/j.pharep.2016.12.004_bib0145","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0031-9384(90)90339-6","article-title":"Behavior of streptozotocin-diabetic mice in tests of exploration: locomotion, anxiety, depression and aggression","volume":"48","author":"Hilakivi-Clarke","year":"1990","journal-title":"Physiol Behav"},{"key":"10.1016\/j.pharep.2016.12.004_bib0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.psyneuen.2010.10.001","article-title":"Blockade of brain angiotensin II AT1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: therapeutic implications","volume":"36","author":"Saavedra","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.pharep.2016.12.004_bib0155","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0006-8993(99)02289-1","article-title":"Long-term fluoxetine produces behavioral anxiolytic effects without inhibiting neuroendocrine responses to conditioned stress in rats","volume":"855","author":"Zhang","year":"2000","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/j.pharep.2016.12.004_bib0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00427414","article-title":"The validity of animal models of depression","volume":"83","author":"Willner","year":"1984","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pharep.2016.12.004_bib0165","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/0471142301.ns0810as55","article-title":"Rodent models of depression: forced swim and tail suspension behavioral despair tests in rats and mice","volume":"55","author":"Castagne","year":"2011","journal-title":"Curr Protoc Neurosci"},{"key":"10.1016\/j.pharep.2016.12.004_bib0170","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1517\/14728222.8.1.7","article-title":"Angiotensin as a target for the treatment of Alzheimer\u2019s disease, anxiety and depression","volume":"8","author":"Gard","year":"2004","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.pharep.2016.12.004_bib0175","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/00060793-199608000-00001","article-title":"The role of oxidative stress in diabetic complications","volume":"3","author":"Baynes","year":"1996","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"4","key":"10.1016\/j.pharep.2016.12.004_bib0180","doi-asserted-by":"crossref","first-page":"e0125270","DOI":"10.1371\/journal.pone.0125270","article-title":"Hyperglycaemia enhances nitric oxide production in diabetes: a study from South Indian patients","volume":"10","author":"Adela","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.pharep.2016.12.004_bib0185","doi-asserted-by":"crossref","first-page":"e20987","DOI":"10.5812\/scimetr.20987","article-title":"The role of nitric oxide in health and diseases","volume":"3","author":"Khazan","year":"2014","journal-title":"Scimetr"},{"issue":"9","key":"10.1016\/j.pharep.2016.12.004_bib0190","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1055\/s-0030-1255033","article-title":"Metformin attenuates production of nitric oxide in response to lipopolysaccharide by inhibiting MyD88-independent pathway","volume":"42","author":"Kato","year":"2010","journal-title":"Horm Metab Res"},{"issue":"5","key":"10.1016\/j.pharep.2016.12.004_bib0195","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1902\/jop.2011.110370","article-title":"Fluoxetine inhibits inflammatory response and bone loss in a rat model of ligature-induced periodontitis","volume":"83","author":"Branco-de-Almeida","year":"2012","journal-title":"J Periodontol"},{"key":"10.1016\/j.pharep.2016.12.004_bib0200","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1515\/znc-2015-5031","article-title":"Protective effect of telmisartan treatment against arsenic-induced testicular toxicity in rats","volume":"70","author":"Fouad","year":"2015","journal-title":"Z Naturforsch C"},{"key":"10.1016\/j.pharep.2016.12.004_bib0205","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1161\/01.HYP.35.1.108","article-title":"Metformin improves vascular function in insulin-resistant rats","volume":"35","author":"Katakam","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.pharep.2016.12.004_bib0210","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.neubiorev.2008.04.001","article-title":"Stress as a neuroinflammatory condition in brain: damaging and protective mechanisms","volume":"32","author":"Garcia-Bueno","year":"2008","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pharep.2016.12.004_bib0215","doi-asserted-by":"crossref","first-page":"41","DOI":"10.31887\/DCNS.2011.13.1\/rshelton","article-title":"Inflammation in depression: is adiposity a cause?","volume":"13","author":"Shelton","year":"2011","journal-title":"Dialogues Clin Neurosci"},{"key":"10.1016\/j.pharep.2016.12.004_bib0220","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.bbi.2010.03.011","article-title":"Elevated Macrophage Migration Inhibitory Factor (MIF) is associated with depressive symptoms, blunted cortisol reactivity to acute stress, and lowered morning cortisol","volume":"24","author":"Edwards","year":"2010","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.pharep.2016.12.004_bib0225","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1176\/appi.ajp.160.9.1554","article-title":"When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders","volume":"160","author":"Raison","year":"2003","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharep.2016.12.004_bib0230","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1465-9921-8-35","article-title":"Anti-inflammatory properties of desipramine and Fluoxetine","volume":"8","author":"Roumestan","year":"2007","journal-title":"Respir Res"},{"key":"10.1016\/j.pharep.2016.12.004_bib0235","first-page":"S123","article-title":"Evaluation of standardized extract of Centella asciatica leaves on suicidal behavior-related traits in laboratory rats","volume":"45","author":"Aswar","year":"2013","journal-title":"Indian J Pharmacol"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114016304261?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114016304261?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:36:49Z","timestamp":1752611809000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1016\/j.pharep.2016.12.004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S1734114016304261"],"URL":"https:\/\/doi.org\/10.1016\/j.pharep.2016.12.004","relation":{},"ISSN":["1734-1140"],"issn-type":[{"value":"1734-1140","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Telmisartan attenuates diabetes induced depression in rats","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharep.2016.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Sp. z o.o. on behalf of Institute of Pharmacology, Polish Academy of Sciences.","name":"copyright","label":"Copyright"}]}}