{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:06:33Z","timestamp":1760299593555,"version":"3.41.2"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004442","name":"National Science Centre","doi-asserted-by":"crossref","award":["UMO-2015\/17\/B\/NZ4\/01763"],"award-info":[{"award-number":["UMO-2015\/17\/B\/NZ4\/01763"]}],"id":[{"id":"10.13039\/501100004442","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Reports"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.pharep.2017.05.005","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T13:45:16Z","timestamp":1494510316000},"page":"1173-1177","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Sotalol enhances the anticonvulsant action of valproate and diphenylhydantoin in the mouse maximal electroshock model"],"prefix":"10.1007","volume":"69","author":[{"given":"Monika","family":"Banach","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Pop\u0142awska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kinga K.","family":"Borowicz-Reutt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"issue":"8","key":"10.1016\/j.pharep.2017.05.005_bib0005","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1111\/j.1528-1167.2012.03518.x","article-title":"Comparison of heart rate variability parameters during complex partial seizures and psychogenic nonepileptic seizures","volume":"53","author":"Ponnusamy","year":"2012","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.pharep.2017.05.005_bib0010","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nrneurol.2014.64","article-title":"Mechanisms of sudden unexpected death in epilepsy: the pathway to prevention","volume":"10","author":"Massey","year":"2014","journal-title":"Nat Rev Neurol"},{"issue":"3","key":"10.1016\/j.pharep.2017.05.005_bib0015","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.eplepsyres.2011.12.003","article-title":"\u03b2 Adrenergic blockade prevents cardiac dysfunction following status epilepticus in rats","volume":"99","author":"Little","year":"2012","journal-title":"Epilepsy Res"},{"issue":"4","key":"10.1016\/j.pharep.2017.05.005_bib0020","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.0013-9580.2004.05503.x","article-title":"EEG and ECG in sudden unexplained death in epilepsy","volume":"45","author":"Nei","year":"2004","journal-title":"Epilepsia"},{"issue":"28","key":"10.1016\/j.pharep.2017.05.005_bib0025","doi-asserted-by":"crossref","first-page":"10281","DOI":"10.1523\/JNEUROSCI.0888-15.2015","article-title":"Breathing inhibited when seizures spread to the amygdala and upon amygdala stimulation","volume":"35","author":"Dlouhy","year":"2015","journal-title":"J Neurosci"},{"issue":"1\u20132","key":"10.1016\/j.pharep.2017.05.005_bib0030","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0304-3940(94)11548-1","article-title":"Reactive microglia in hippocampal sclerosis associated with human temporal lobe epilepsy","volume":"191","author":"Beach","year":"1995","journal-title":"Neurosci Lett"},{"issue":"32","key":"10.1016\/j.pharep.2017.05.005_bib0035","doi-asserted-by":"crossref","first-page":"10528","DOI":"10.1523\/JNEUROSCI.0416-14.2014","article-title":"Neuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus","volume":"34","author":"Eyo","year":"2014","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharep.2017.05.005_bib0040","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1742-2094-9-27","article-title":"Neuroprotective function for ramified microglia in hippocampal excitotoxicity","volume":"9","author":"Vinet","year":"2012","journal-title":"J Neuroinflamm"},{"key":"10.1016\/j.pharep.2017.05.005_bib0045","doi-asserted-by":"crossref","first-page":"11499","DOI":"10.1038\/ncomms11499","article-title":"Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke","volume":"7","author":"Szalay","year":"2016","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.pharep.2017.05.005_bib0050","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/glia.20467","article-title":"Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration","volume":"55","author":"Qin","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.pharep.2017.05.005_bib0055","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.nicl.2014.06.010","article-title":"Evidence for brainstem network disruption in temporal lobe epilepsy and sudden unexplained death in epilepsy","volume":"5","author":"Mueller","year":"2014","journal-title":"Neuroimage Clin"},{"issue":"3","key":"10.1016\/j.pharep.2017.05.005_bib0060","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S0002-8703(99)70484-9","article-title":"An important new antiarrhythmic","volume":"137","author":"Anderson","year":"1999","journal-title":"Am Heart J"},{"issue":"2","key":"10.1016\/j.pharep.2017.05.005_bib0065","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0022-3565(25)21592-0","article-title":"Antiarrhythmic and antifibrillatory actions of the beta adrenergic receptor antagonist, dl-sotalol","volume":"230","author":"Patterson","year":"1984","journal-title":"J Pharm Exp Ther"},{"issue":"3\u20134","key":"10.1016\/j.pharep.2017.05.005_bib0070","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3109\/01677063.2012.674993","article-title":"KCNH2 gene mutation: a potential link between epilepsy and long QT-2 syndrome","volume":"26","author":"Zamorano-Le\u00f3n","year":"2012","journal-title":"J Neurogenet"},{"issue":"2","key":"10.1016\/j.pharep.2017.05.005_bib0075","first-page":"128","article-title":"Effect of beta-adrenoceptor antagonists and some related drugs on maximal electroshock seizures in mice","volume":"27","author":"Khanna","year":"1989","journal-title":"Indian J Exp Biol"},{"issue":"1-2","key":"10.1016\/j.pharep.2017.05.005_bib0080","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0091-3057(01)00654-2","article-title":"Propranolol and metoprolol enhance the anticonvulsant action of valproate and diazepam against maximal electroshock","volume":"71","author":"Luchowska","year":"2002","journal-title":"Pharmacol Biochem Behav"},{"issue":"2","key":"10.1016\/j.pharep.2017.05.005_bib0085","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1080\/01616412.2015.1136779","article-title":"The interaction between morphine and propranolol in chemical and electrical seizure models of mice","volume":"38","author":"Shafaroodi","year":"2016","journal-title":"Neurol Res"},{"issue":"5","key":"10.1016\/j.pharep.2017.05.005_bib0090","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1213\/ane.0b013e31816ba49d","article-title":"Propranolol increases the threshold for lidocaine-induced convulsions in awake rats: a direct effect on the brain","volume":"106","author":"Nakamura","year":"2008","journal-title":"Anesth Analg"},{"issue":"5","key":"10.1016\/j.pharep.2017.05.005_bib0095","first-page":"429","article-title":"Influence of beta adrenergic blockers and their combinations with anticholinergic drugs on epileptiform activity in rabbit hippocampus","volume":"46","author":"Tkatchenko","year":"1987","journal-title":"Biomed Biochim Acta"},{"issue":"4","key":"10.1016\/j.pharep.2017.05.005_bib0100","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/0278-5846(94)90082-5","article-title":"Strychnine-induced seizures in mice: the role of noradrenaline","volume":"18","author":"Amabeoku","year":"1994","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"3","key":"10.1016\/j.pharep.2017.05.005_bib0105","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0091-3057(00)00385-3","article-title":"Beta-1 adrenoceptor antagonists potentiate the anticonvulsive effect of swim stress in mice","volume":"67","author":"Pericic","year":"2000","journal-title":"Pharmacol Biochem Behav"},{"issue":"3","key":"10.1016\/j.pharep.2017.05.005_bib0110","first-page":"175","article-title":"The effect of beta-adrenoceptor antagonists alone and in combination with a GABA-elevating agent on isoniazid-induced convulsions in rats","volume":"33","author":"Paul","year":"1989","journal-title":"Indian J Physiol Pharmacol"},{"issue":"5","key":"10.1016\/j.pharep.2017.05.005_bib0115","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/0091-3057(85)90518-0","article-title":"A possible role for beta-adrenergic receptors in the expression of audiogenic seizures","volume":"22","author":"Lints","year":"1985","journal-title":"Pharmacol Biochem Behav"},{"issue":"3","key":"10.1016\/j.pharep.2017.05.005_bib0120","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0014-2999(02)01536-4","article-title":"Influence of some beta-adrenoceptor antagonists on the anticonvulsant potency of antiepileptic drugs against audiogenic seizures in DBA\/2 mice","volume":"442","author":"De Sarro","year":"2002","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"10.1016\/j.pharep.2017.05.005_bib0125","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/0920-1211(89)90057-0","article-title":"Anticonvulsant and antiarrhythmic actions of the beta blocking agent timolol","volume":"4","author":"Lathers","year":"1989","journal-title":"Epilepsy Res"},{"issue":"4","key":"10.1016\/j.pharep.2017.05.005_bib0130","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.pharep.2014.03.009","article-title":"Antiarrhythmic drugs and epilepsy","volume":"66","author":"Borowicz","year":"2014","journal-title":"Pharmacol Rep"},{"issue":"2","key":"10.1016\/j.pharep.2017.05.005_bib0135","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1358\/mf.2009.31.2.1338414","article-title":"The maximal electroshock seizure (MES) model in the preclinical assessment of potential new antiepileptic drug","volume":"31","author":"Castel-Branco","year":"2009","journal-title":"Methods Find Exp Clin Pharmacol"},{"issue":"2","key":"10.1016\/j.pharep.2017.05.005_bib0140","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00213-007-0878-9","article-title":"Acute and chronic treatment with mianserin differentially affects the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock model","volume":"195","author":"Borowicz","year":"2007","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.pharep.2017.05.005_bib0145","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0022-3565(25)03549-9","article-title":"A simplified method of evaluating dose-effect experiments","volume":"96","author":"Litchfield","year":"1949","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pharep.2017.05.005_bib0150","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000134913","article-title":"Une nouvelle methode simple pour explorer l\u2019action tranquilisante: le test de la cheminee","volume":"3","author":"Boissier","year":"1960","journal-title":"Med Exp (Basel)"},{"key":"10.1016\/j.pharep.2017.05.005_bib0155","first-page":"CD005049","article-title":"Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation","volume":"3","author":"Lafuente-Lafuente","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"10.1016\/j.pharep.2017.05.005_bib0160","first-page":"296","article-title":"Influence of carvedilol on anticonvulsant effect of gabapentin","volume":"111","author":"Goel","year":"2011","journal-title":"Acta Neurol Belg"},{"issue":"1","key":"10.1016\/j.pharep.2017.05.005_bib0165","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0014-2999(91)90650-F","article-title":"Diazepam-atenolol combination antagonizes aminophylline-induced convulsions and lethality in mice","volume":"199","author":"Chugh","year":"1991","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"10.1016\/j.pharep.2017.05.005_bib0170","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0304-3940(99)00321-3","article-title":"Pindolol potentiates the effect of fluoxetine on hippocampal seizures in rats","volume":"267","author":"Wada","year":"1999","journal-title":"Neurosci Lett"},{"issue":"6","key":"10.1016\/j.pharep.2017.05.005_bib0175","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1006\/phrs.1998.0390","article-title":"Effect of propranolol and nifedipine on maximal electroshock-induced seizures in mice: individually and in combination","volume":"38","author":"Raju","year":"1998","journal-title":"Pharmacol Res"},{"issue":"1","key":"10.1016\/j.pharep.2017.05.005_bib0180","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00045391-199406000-00007","article-title":"Propranolol action in chronically unstable generalized epilepsy","volume":"1","author":"de Oliveira","year":"1994","journal-title":"Am J Ther"},{"issue":"3","key":"10.1016\/j.pharep.2017.05.005_bib0185","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1136\/jnnp.58.3.382","article-title":"Propranolol in startle induced epileptic seizures","volume":"58","author":"Mayer","year":"1995","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3","key":"10.1016\/j.pharep.2017.05.005_bib0190","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.pharep.2016.01.002","article-title":"Propafenone enhances the anticonvulsant action of classical antiepileptic drugs in the mouse maximal electroshock model","volume":"68","author":"Banach","year":"2016","journal-title":"Pharmacol Rep"},{"issue":"3","key":"10.1016\/j.pharep.2017.05.005_bib0195","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2007","journal-title":"FASEB J"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S173411401730169X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S173411401730169X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:37:09Z","timestamp":1752611829000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1016\/j.pharep.2017.05.005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S173411401730169X"],"URL":"https:\/\/doi.org\/10.1016\/j.pharep.2017.05.005","relation":{},"ISSN":["1734-1140"],"issn-type":[{"type":"print","value":"1734-1140"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sotalol enhances the anticonvulsant action of valproate and diphenylhydantoin in the mouse maximal electroshock model","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharep.2017.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Sp. z o.o. All rights reserved.","name":"copyright","label":"Copyright"}]}}