{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T03:43:09Z","timestamp":1774323789823,"version":"3.50.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Conacyt-M\u00e9xico to S\u00e1nchez-Pastor","award":["152773"],"award-info":[{"award-number":["152773"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Reports"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.pharep.2017.06.011","type":"journal-article","created":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T12:45:49Z","timestamp":1498913149000},"page":"1131-1139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["ACPA and JWH-133 modulate the vascular tone of superior mesenteric arteries through cannabinoid receptors, BK Ca channels, and nitric oxide dependent mechanisms"],"prefix":"10.1007","volume":"69","author":[{"given":"Evelyn","family":"L\u00f3pez-Dyck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipa","family":"Andrade-Urz\u00faa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Elizalde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Ferrer-Villada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adan","family":"Dagnino-Acosta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Huerta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zyanya","family":"Osuna-Calleros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinthia","family":"Rangel-Sandoval","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"S\u00e1nchez-Pastor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"10.1016\/j.pharep.2017.06.011_bib0005","first-page":"69","article-title":"Calcium-activated potassium channels and the regulation of vascular tone","volume":"21","author":"LeDoux","year":"2006","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.pharep.2017.06.011_bib0010","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1111\/j.1476-5381.2009.00396.x","article-title":"Vasodilator efficacy of nitric oxide depends on mechanisms of intracellular calcium mobilization in mouse aortic smooth muscle cells","volume":"158","author":"Van Hove","year":"2009","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharep.2017.06.011_bib0015","doi-asserted-by":"crossref","first-page":"H1446","DOI":"10.1152\/ajpheart.00506.2012","article-title":"Hydrogen sulfide dilates rat mesenteric arteries by activating endothelial large-conductance Ca(2)(+)-activated K(+) channels and smooth muscle Ca(2)(+) sparks","volume":"304","author":"Jackson-Weaver","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.pharep.2017.06.011_bib0020","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00210-007-0193-3","article-title":"Vascular large conductance calcium-activated potassium channels: functional role and therapeutic potential","volume":"376","author":"Eichhorn","year":"2007","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.pharep.2017.06.011_bib0025","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.neuropharm.2004.12.005","article-title":"Blood pressure regulation by endocannabinoids and their receptors","volume":"48","author":"Pacher","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharep.2017.06.011_bib0030","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1124\/pr.110.003004","article-title":"International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB(1) and CB(2)","volume":"62","author":"Pertwee","year":"2010","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.pharep.2017.06.011_bib0035","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s00424-012-1083-1","article-title":"Influence of methanandamide and CGRP on potassium currents in smooth muscle cells of small mesenteric arteries","volume":"463","author":"Bol","year":"2012","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.pharep.2017.06.011_bib0040","doi-asserted-by":"crossref","first-page":"H2046","DOI":"10.1152\/ajpheart.00497.2001","article-title":"Anandamide-induced vasorelaxation in rabbit aortic rings has two components: G protein dependent and independent","volume":"282","author":"Mukhopadhyay","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.pharep.2017.06.011_bib0045","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.phrs.2016.08.028","article-title":"The endocannabinoid anandamide causes endothelium-dependent vasorelaxation in human mesenteric arteries","volume":"113","author":"Stanley","year":"2016","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.pharep.2017.06.011_bib0050","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1124\/pr.54.2.161","article-title":"International Union of Pharmacology. XXVII. Classification of cannabinoid receptors","volume":"54","author":"Howlett","year":"2002","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.pharep.2017.06.011_bib0055","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ejphar.2014.02.016","article-title":"Cannabinoid receptor type 1 activation by arachidonylcyclopropylamide in rat aortic rings causes vasorelaxation involving calcium-activated potassium channel subunit alpha-1 and calcium channel, voltage-dependent, L type, alpha 1C subunit","volume":"729","author":"Sanchez-Pastor","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharep.2017.06.011_bib0060","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/3-540-26573-2_2","article-title":"Cannabinoid receptor signaling","author":"Howlett","year":"2005","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.pharep.2017.06.011_bib0065","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pharmthera.2005.10.007","article-title":"Large-conductance, calcium-activated potassium channels: structural and functional implications","volume":"110","author":"Ghatta","year":"2006","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.pharep.2017.06.011_bib0070","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/BF00584965","article-title":"Calcium currents of isolated bovine ventricular myocytes are fast and of large amplitude","volume":"395","author":"Isenberg","year":"1982","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.pharep.2017.06.011_bib0075","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.pharmthera.2004.11.005","article-title":"Evidence for novel cannabinoid receptors","volume":"106","author":"Begg","year":"2005","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.pharep.2017.06.011_bib0080","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/sj.bjp.0707569","article-title":"CB2 cannabinoid receptor agonists attenuate TNF-alpha-induced human vascular smooth muscle cell proliferation and migration","volume":"153","author":"Rajesh","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharep.2017.06.011_bib0085","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.neulet.2008.09.078","article-title":"Differential coupling of the human cannabinoid receptors hCB1R and hCB2R to the G-protein G(alpha)i2beta1gamma2","volume":"447","author":"Nickl","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pharep.2017.06.011_bib0090","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.2174\/092986710790980023","article-title":"CB(1) cannabinoid receptors and their associated proteins","volume":"17","author":"Howlett","year":"2010","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.pharep.2017.06.011_bib0095","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1085\/jgp.201210849","article-title":"Perspectives on: conformational coupling in ion channels: conformational coupling in BK potassium channels","volume":"140","author":"Horrigan","year":"2012","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.pharep.2017.06.011_bib0100","doi-asserted-by":"crossref","first-page":"19096","DOI":"10.1073\/pnas.1002685107","article-title":"Thromboxane A2 receptor and MaxiK-channel intimate interaction supports channel trans-inhibition independent of G-protein activation","volume":"107","author":"Li","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharep.2017.06.011_bib0105","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/sj.bjp.0705810","article-title":"Heterogeneity in the mechanisms of vasorelaxation to anandamide in resistance and conduit rat mesenteric arteries","volume":"142","author":"O\u2019Sullivan","year":"2004","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharep.2017.06.011_bib0110","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/sj.bjp.0705725","article-title":"The complexities of the cardiovascular actions of cannabinoids","volume":"142","author":"Randall","year":"2004","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharep.2017.06.011_bib0115","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.vph.2006.06.005","article-title":"Vasorelaxant effect of Win 55,212-2 in rat aorta: new mechanisms involved","volume":"46","author":"Dannert","year":"2007","journal-title":"Vasc Pharmacol"},{"issue":"November","key":"10.1016\/j.pharep.2017.06.011_bib0120","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/sj.bjp.0707404","article-title":"Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta","volume":"152","author":"Herradon","year":"2007","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharep.2017.06.011_bib0125","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1124\/jpet.105.095828","article-title":"Further characterization of the time-dependent vascular effects of delta9-tetrahydrocannabinol","volume":"317","author":"O\u2019Sullivan","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pharep.2017.06.011_bib0130","doi-asserted-by":"crossref","first-page":"14136","DOI":"10.1073\/pnas.96.24.14136","article-title":"Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors","volume":"96","author":"Jarai","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharep.2017.06.011_bib0135","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1152\/advan.00025.2003","article-title":"Smooth muscle contraction and relaxation","volume":"27","author":"Webb","year":"2003","journal-title":"Adv Physiol Educ"},{"key":"10.1016\/j.pharep.2017.06.011_bib0140","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1139\/y2012-073","article-title":"The endothelium: influencing vascular smooth muscle in many ways","volume":"90","author":"Triggle","year":"2012","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.pharep.2017.06.011_bib0145","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/10739680590896072","article-title":"Potassium channels in the peripheral microcirculation","volume":"12","author":"Jackson","year":"2005","journal-title":"Microcirculation"},{"key":"10.1016\/j.pharep.2017.06.011_bib0150","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1152\/physrev.00030.2007","article-title":"Calcium sparks","volume":"88","author":"Cheng","year":"2008","journal-title":"Physiol Rev"},{"key":"10.1016\/j.pharep.2017.06.011_bib0155","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.bbrc.2014.01.150","article-title":"Calcium oscillations in human mesenteric vascular smooth muscle","volume":"445","author":"Navarro-Dorado","year":"2014","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114017300361?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114017300361?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:37:13Z","timestamp":1752611833000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1016\/j.pharep.2017.06.011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S1734114017300361"],"URL":"https:\/\/doi.org\/10.1016\/j.pharep.2017.06.011","relation":{},"ISSN":["1734-1140"],"issn-type":[{"value":"1734-1140","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ACPA and JWH-133 modulate the vascular tone of superior mesenteric arteries through cannabinoid receptors, BKCa channels, and nitric oxide dependent mechanisms","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharep.2017.06.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Sp. z o.o. All rights reserved.","name":"copyright","label":"Copyright"}]}}