{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T11:41:09Z","timestamp":1778758869844,"version":"3.51.4"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Reports"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.pharep.2018.02.013","type":"journal-article","created":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T12:52:53Z","timestamp":1518439973000},"page":"699-704","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Multi-targeting effects of a new synthetic molecule (JM-20) in experimental models of cerebral ischemia"],"prefix":"10.1007","volume":"70","author":[{"given":"Yanier","family":"Nu\u00f1ez-Figueredo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeney","family":"Ram\u00edrez-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilberto L.","family":"Pardo Andreu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estael","family":"Ochoa-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yamila","family":"Verdecia-Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diogo O.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"10.1016\/j.pharep.2018.02.013_bib0005","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nrneurol.2010.36","article-title":"Ischemic stroke in the elderly: an overview of evidence","volume":"6","author":"Chen","year":"2010","journal-title":"Nat Rev Neurol."},{"key":"10.1016\/j.pharep.2018.02.013_bib0010","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1161\/CIR.0000000000000350","article-title":"Heart disease and stroke statistics-2016 update: a report from the american heart association","volume":"133","author":"Mozaffarian","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.pharep.2018.02.013_bib0015","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.brainresbull.2016.02.016","article-title":"A review on animal models of stroke: an update","volume":"122","author":"Kumar","year":"2016","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.pharep.2018.02.013_bib0020","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.neuron.2015.05.041","article-title":"Novel stroke therapeutics: unraveling stroke pathophysiology and its impact on clinical treatments","volume":"87","author":"George","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.pharep.2018.02.013_bib0025","doi-asserted-by":"crossref","first-page":"e1000224","DOI":"10.1371\/journal.pmed.1000224","article-title":"Where will the next generation of stroke treatments come from?","volume":"7","author":"Howells","year":"2010","journal-title":"PLoS Med"},{"key":"10.1016\/j.pharep.2018.02.013_bib0030","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.pneurobio.2013.03.002","article-title":"Multiple interacting cell death mechanisms in the mediation of excitotoxicity and ischemic brain damage: a challenge for neuroprotection","volume":"105","author":"Puyal","year":"2013","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.pharep.2018.02.013_bib0035","doi-asserted-by":"crossref","first-page":"964518","DOI":"10.1155\/2015\/964518","article-title":"Mechanisms of neuronal protection against excitotoxicity, endoplasmic reticulum stress, and mitochondrial dysfunction in stroke and neurodegenerative diseases","volume":"2015","author":"Prentice","year":"2015","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.pharep.2018.02.013_bib0040","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1586\/ecp.11.13","article-title":"The use of multi-target drugs in the treatment of neurodegenerative diseases","volume":"4","author":"Van der Schyf","year":"2011","journal-title":"Expert Rev Clin Pharmacol"},{"key":"10.1016\/j.pharep.2018.02.013_bib0045","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s12975-011-0074-4","article-title":"Emerging therapies: pleiotropic multi-target drugs to treat stroke victims","volume":"2","author":"Lapchak","year":"2011","journal-title":"Transl Stroke Res"},{"key":"10.1016\/j.pharep.2018.02.013_bib0050","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.nurt.2008.10.032","article-title":"Multifunctional actions of approved and candidate stroke drugs","volume":"6","author":"Minnerup","year":"2009","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.pharep.2018.02.013_bib0055","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1021\/jm7009364","article-title":"Multi-target-directed ligands to combat neurodegenerative diseases","volume":"51","author":"Cavalli","year":"2008","journal-title":"J Med Chem"},{"key":"10.1016\/j.pharep.2018.02.013_bib0060","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1179\/1743132813Y.0000000216","article-title":"Characterization of the anxiolytic and sedative profile of JM-20: a novel benzodiazepine-dihydropyridine hybrid molecule","volume":"35","author":"Figueredo","year":"2013","journal-title":"Neurol Res"},{"key":"10.1016\/j.pharep.2018.02.013_bib0065","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.neuropharm.2012.12.001","article-title":"Novel multitarget ligand ITH33\/IQM9.21 provides neuroprotection in vitro and in vivo models related to brain ischemia","volume":"67","author":"Lorrio","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharep.2018.02.013_bib0070","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s12640-015-9553-9","article-title":"Effects of the hybridization of opioid and neurotensin pharmacophores on cell survival in rat organotypic hippocampal slice cultures","volume":"28","author":"Kleczkowska","year":"2015","journal-title":"Neurotox Res"},{"key":"10.1016\/j.pharep.2018.02.013_bib0075","doi-asserted-by":"crossref","first-page":"37148","DOI":"10.1038\/srep37148","article-title":"Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.pharep.2018.02.013_bib0080","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ejphar.2014.01.021","article-title":"JM-20, a novel benzodiazepine-dihydropyridine hybrid molecule, protects mitochondria and prevents ischemic insult-mediated neural cell death in vitro","volume":"726","author":"Nunez-Figueredo","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharep.2018.02.013_bib0085","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.neuropharm.2014.06.009","article-title":"A novel multi-target ligand (JM-20) protects mitochondrial integrity, inhibits brain excitatory amino acid release and reduces cerebral ischemia injury in vitro and in vivo","volume":"85","author":"Nunez-Figueredo","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharep.2018.02.013_bib0090","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.neuint.2015.09.003","article-title":"Neuroprotection by JM-20 against oxygen-glucose deprivation in rat hippocampal slices: involvement of the Akt\/GSK-3beta pathway","volume":"90","author":"Ramirez-Sanchez","year":"2015","journal-title":"Neurochem Int"},{"key":"10.1016\/j.pharep.2018.02.013_bib0095","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.brainresbull.2014.10.001","article-title":"Antioxidant effects of JM-20 on rat brain mitochondria and synaptosomes: mitoprotection against Ca(2)(+)-induced mitochondrial impairment","volume":"109","author":"Nunez-Figueredo","year":"2014","journal-title":"Brain Res Bull."},{"key":"10.1016\/j.pharep.2018.02.013_bib0100","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neuint.2015.01.006","article-title":"The effects of JM-20 on the glutamatergic system in synaptic vesicles, synaptosomes and neural cells cultured from rat brain","volume":"81","author":"Nunez-Figueredo","year":"2015","journal-title":"Neurochem Int"},{"key":"10.1016\/j.pharep.2018.02.013_bib0105","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0024-3205(01)01142-0","article-title":"Glutamate release and neuronal damage in ischemia","volume":"69","author":"Nishizawa","year":"2001","journal-title":"Life Sci"},{"key":"10.1016\/j.pharep.2018.02.013_bib0110","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1152\/physrev.1999.79.2.361","article-title":"Vacuolar and plasma membrane proton-adenosinetriphosphatases","volume":"79","author":"Nelson","year":"1999","journal-title":"Physiol Rev"},{"key":"10.1016\/j.pharep.2018.02.013_bib0115","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0168-0102(00)00124-3","article-title":"Oxidative glutamate toxicity involves mitochondrial dysfunction and perturbation of intracellular Ca2+ homeostasis","volume":"37","author":"Pereira","year":"2000","journal-title":"Neurosci Res"},{"key":"10.1016\/j.pharep.2018.02.013_bib0120","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0161-813X(03)00042-1","article-title":"Cyanide enhancement of dopamine-induced apoptosis in mesencephalic cells involves mitochondrial dysfunction and oxidative stress","volume":"24","author":"Jones","year":"2003","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.pharep.2018.02.013_bib0125","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1111\/j.1471-4159.2004.02572.x","article-title":"Mitochondrial mechanisms of neural cell apoptosis","volume":"90","author":"Polster","year":"2004","journal-title":"J Neurochem"},{"key":"10.1016\/j.pharep.2018.02.013_bib0130","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3233\/JAD-2010-100174","article-title":"Dimebon (latrepirdine) enhances mitochondrial function and protects neuronal cells from death","volume":"21","author":"Zhang","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.pharep.2018.02.013_bib0135","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s12031-009-9285-5","article-title":"Neuroprotective effect of baicalein on hydrogen peroxide-mediated oxidative stress and mitochondrial dysfunction in PC12 cells","volume":"40","author":"Zhang","year":"2010","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.pharep.2018.02.013_bib0140","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/ana.20741","article-title":"1,026 experimental treatments in acute stroke","volume":"59","author":"O\u2019Collins","year":"2006","journal-title":"Ann Neurol"},{"key":"10.1016\/j.pharep.2018.02.013_bib0145","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1517\/13543784.2015.1065040","article-title":"Advanced neuroprotection for brain ischemia: an alternative approach to minimize stroke damage","volume":"24","author":"Ayuso","year":"2015","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.pharep.2018.02.013_bib0150","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1161\/01.STR.32.6.1349","article-title":"Trends in acute ischemic stroke trials through the 20th century","volume":"32","author":"Kidwell","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.pharep.2018.02.013_bib0155","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1038\/sj.jcbfm.9600298","article-title":"Bench to bedside: the quest for quality in experimental stroke research","volume":"26","author":"Dirnagl","year":"2006","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.pharep.2018.02.013_bib0160","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/ilar\/ilu037","article-title":"Refinement of experimental design and conduct in laboratory animal research","volume":"55","author":"Bailoo","year":"2014","journal-title":"ILAR J"},{"key":"10.1016\/j.pharep.2018.02.013_bib0165","doi-asserted-by":"crossref","first-page":"153","DOI":"10.56499\/jppres16.126_4.4.153","article-title":"Therapeutic potential of the novel hybrid molecule JM-20 against focal cortical ischemia in rats","volume":"4","author":"N\u00fa\u00f1ez-Figueredo","year":"2016","journal-title":"J Pharm Pharmacogn Res"},{"key":"10.1016\/j.pharep.2018.02.013_bib0170","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/2040-7378-1-8","article-title":"Rodent models of focal cerebral ischemia: procedural pitfalls and translational problems","volume":"1","author":"Braeuninger","year":"2009","journal-title":"Exp Transl Stroke Med"},{"key":"10.1016\/j.pharep.2018.02.013_bib0175","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0166-2236(03)00071-7","article-title":"Ischemic tolerance and endogenous neuroprotection","volume":"26","author":"Dirnagl","year":"2003","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.pharep.2018.02.013_bib0180","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1161\/STROKEAHA.108.541128","article-title":"Update of the stroke therapy academic industry roundtable preclinical recommendations","volume":"40","author":"Fisher","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.pharep.2018.02.013_bib0185","doi-asserted-by":"crossref","first-page":"549","DOI":"10.21037\/atm.2016.12.41","article-title":"Preclinical randomized controlled multicenter trials (pRCT) in stroke research: a new and valid approach to improve translation?","volume":"4","author":"Balduini","year":"2016","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.pharep.2018.02.013_bib0190","doi-asserted-by":"crossref","first-page":"299ra121","DOI":"10.1126\/scitranslmed.aaa9853","article-title":"Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia","volume":"7","author":"Llovera","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.pharep.2018.02.013_bib0195","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.expneurol.2016.10.014","article-title":"Neuroprotective effect of lercanidipine in middle cerebral artery occlusion model of stroke in rats","volume":"288","author":"Gupta","year":"2017","journal-title":"Exp Neurol"},{"key":"10.1016\/j.pharep.2018.02.013_bib0200","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.expneurol.2008.08.009","article-title":"Bazan NG. LAU-0901, a novel platelet-activating factor antagonist, is highly neuroprotective in cerebral ischemia","volume":"214","author":"Belayev","year":"2008","journal-title":"Exp Neurol"},{"key":"10.1016\/j.pharep.2018.02.013_bib0205","first-page":"337","article-title":"The effects of nimodipine on regional cerebral blood flow, brain water and electrolyte contents in rats with subarachnoid hemorrhage","volume":"29","author":"Sun","year":"2003","journal-title":"Clin Hemorheol Microcirc"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114017303882?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114017303882?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:37:33Z","timestamp":1752611853000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1016\/j.pharep.2018.02.013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S1734114017303882"],"URL":"https:\/\/doi.org\/10.1016\/j.pharep.2018.02.013","relation":{},"ISSN":["1734-1140"],"issn-type":[{"value":"1734-1140","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-targeting effects of a new synthetic molecule (JM-20) in experimental models of cerebral ischemia","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharep.2018.02.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}