{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T14:25:07Z","timestamp":1754144707967,"version":"3.41.2"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Reports"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.pharep.2018.02.015","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T13:50:56Z","timestamp":1519393856000},"page":"796-803","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cyclophosphamide-modified murine peritoneal macrophages induce CD4+ T contrasuppressor cells that protect contact sensitivity T effector cells from suppression"],"prefix":"10.1007","volume":"70","author":[{"given":"Monika","family":"Majewska-Szczepanik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulina","family":"Kowalczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominika","family":"Bia\u0142a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Marci\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Strz\u0119pa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorota","family":"Wo\u017aniak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Sura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2867-2269","authenticated-orcid":false,"given":"James","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian","family":"Szczepanik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"10.1016\/j.pharep.2018.02.015_bib0005","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.intimp.2014.06.017","article-title":"Probiotic Lactobacillus strains protect against myelosuppression and immunosuppression in cyclophosphamide-treated mice","volume":"22","author":"Salva","year":"2014","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.pharep.2018.02.015_bib0010","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nrclinonc.2009.146","article-title":"Cyclophosphamide and cancer: golden anniversary","volume":"6","author":"Emadi","year":"2009","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.pharep.2018.02.015_bib0015","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00005-010-0075-0","article-title":"Regulatory cell as a target for cancer therapy","volume":"58","author":"De Rezende","year":"2010","journal-title":"Arch Immunol Ther Exp"},{"key":"10.1016\/j.pharep.2018.02.015_bib0020","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s00262-006-0225-8","article-title":"Metronomic cyclophosphamide regimen selectively deplets CD4+ CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients","volume":"56","author":"Ghiringhelli","year":"2007","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.pharep.2018.02.015_bib0025","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00262-011-1106-3","article-title":"Metronomic cyclophosphamide treatment in metastasized breast cancer patients: immunological effects and clinical outcome","volume":"61","author":"Ge","year":"2012","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.pharep.2018.02.015_bib0030","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ctrv.2015.11.005","article-title":"Low dose cyclophosphamide: mechanisms of T cell modulation","volume":"42","author":"Madondo","year":"2015","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.pharep.2018.02.015_bib0035","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1158\/0008-5472.CAN-10-1259","article-title":"The effect of cyclophosphamide on the immune system: implications for clinical cancer therapy","volume":"71","author":"Viaud","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.pharep.2018.02.015_bib0040","first-page":"4384","article-title":"Cyclophosphamide enhances immunity by modulating the balance of dendritic cell subsets in lymphoid organs","volume":"115","author":"Nakahara","year":"2009","journal-title":"Immunobiology"},{"key":"10.1016\/j.pharep.2018.02.015_bib0045","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1084\/jem.184.6.2129","article-title":"\u03b3\u03b4 T cells from tolerized \u03b1\u03b2 T cell receptor (TCR)-deficient mice inhibit contact sensitivity-effector T cells in vivo, and their interferon-\u03b3 production in vitro","volume":"184","author":"Szczepanik","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.pharep.2018.02.015_bib0050","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1002\/eji.1830251103","article-title":"Major histocompatability complex class I-restricted CD8+ T cells and class II-restricted CD4+ T cells, respectively, mediate and regulate contact sensitivity to dinitrofluorobenzene","volume":"25","author":"Bour","year":"1995","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.pharep.2018.02.015_bib0055","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.4049\/jimmunol.168.6.3079","article-title":"Skin inflammation during contact hypersensitivity by early recruitment of CD8+ T cytotoxic 1 cells inducing keratinocytes apoptosis","volume":"168","author":"Akiba","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.pharep.2018.02.015_bib0060","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1111\/j.1365-2133.2009.09400.x","article-title":"Th17\/Tc17 infiltration and associated cytokine gene expression in elicitation phase of allergic contact dermatitis","volume":"161","author":"Zhao","year":"2009","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.pharep.2018.02.015_bib0065","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1365-3083.2011.02522.x","article-title":"Participation of iNKT cells in the early and late components of Tc1 mediated DNFB contact sensitivity: cooperative role of \u03b3\u03b4-T cells","volume":"73","author":"Askenase","year":"2011","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.pharep.2018.02.015_bib0070","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/nyas.12975","article-title":"A subset of AID-dependent B-1a cells initiates hypersensitivity and pneumococcal pneumonia resistance","volume":"1362","author":"Askenase","year":"2015","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.pharep.2018.02.015_bib0075","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jdermsci.2005.02.002","article-title":"Cyclophosphamide decreases the number, percentage and the function of CD25+ CD4+ regulatory T cells, which suppress induction of contact hypersensitivity","volume":"39","author":"Ikezawa","year":"2005","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.pharep.2018.02.015_bib0080","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.4049\/jimmunol.1202464","article-title":"Naturally occurring PD-1+ memory phenotype CD8T cells belong to nonconventional CD8T cells and are cyclophosphamide-sensitive regulatory T cells","volume":"190","author":"Sakuraba","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.pharep.2018.02.015_bib0085","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.4049\/jimmunol.154.8.3644","article-title":"\u03b3\u03b4 T cells in normal spleen assist immunized \u03b1\u03b2 T cells in the adoptive cell transfer of contact sensitivity","volume":"154","author":"Askenase","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.pharep.2018.02.015_bib0090","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1084\/jem.151.2.362","article-title":"Role of antigen-presenting cells in the development and persistence of contact hypersensitivity","volume":"151","author":"Ptak","year":"1980","journal-title":"J Exp Med"},{"key":"10.1016\/j.pharep.2018.02.015_bib0095","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/jlb.53.3.320","article-title":"Distinct populations of antygen-presenting macrophages are required for induction of effector and regulatory cells in contact sensitivity response in mice","volume":"53","author":"Szczepanik","year":"1993","journal-title":"J Leuk Biol"},{"key":"10.1016\/j.pharep.2018.02.015_bib0100","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/S1734-1140(09)70098-2","article-title":"Influence of cyclophosphamide and its metabolic products on activity of peritoneal macrophages in mice","volume":"61","author":"Bryniarski","year":"2009","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.pharep.2018.02.015_bib0105","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1600-0897.2004.00178.x","article-title":"Subpopulations of mouse testicular macrophages and their immunoregulatory function","volume":"52","author":"Bryniarski","year":"2004","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.pharep.2018.02.015_bib0110","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1084\/jem.20021562","article-title":"Cutaneous immunization rapidly activates liver invaraint V\u03b114 NKT cells stimulating B-1 B cells to initiate T cell recruitment for elicitation of contact sensitivity","volume":"198","author":"Campos","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.pharep.2018.02.015_bib0115","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000363446","article-title":"Epicutaneous immunization with TNP-Ig and zymosan induces TCR\u03b1\u03b2+ CD4+ contrasuppressor cells that reverse skin-induced suppression via IL-17A","volume":"164","author":"Majewska-Szczepanik","year":"2014","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.pharep.2018.02.015_bib0120","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.4049\/jimmunol.160.5.2080","article-title":"IL-12 reverses established antigen-specific tolerance ofcontact sensitivity by affecting co-stimulatory molecules B7-1 (CD80) and B7-2 (CD86)","volume":"160","author":"Ushio","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.pharep.2018.02.015_bib0125","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/intimm\/12.1.103","article-title":"IL-12 is produced by antigen-presenting cells stimulated with soluble \u03b1\u03b2TCR and restores impaired Th1 responses","volume":"12","author":"Kawamoto","year":"2000","journal-title":"Int Immunol"},{"key":"10.1016\/j.pharep.2018.02.015_bib0130","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3109\/08820130009060865","article-title":"IL-12 reverses established tolerance mediated by TCR((+ but not by TCR\u03b3\u03b4+ suppressor T cells","volume":"29","author":"Szczepanik","year":"2000","journal-title":"Immunol Invest"},{"key":"10.1016\/j.pharep.2018.02.015_bib0135","doi-asserted-by":"crossref","first-page":"682","DOI":"10.4049\/jimmunol.173.1.682","article-title":"\u03b3\u03b4 T cells enhance the expression of experimental autoimmune encephalomyelitis by promoting antigen presentation and IL-12 production","volume":"173","author":"Odyniec","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.pharep.2018.02.015_bib0140","doi-asserted-by":"crossref","first-page":"837","DOI":"10.4049\/jimmunol.182.2.837","article-title":"Epicutaneous immunization with protein antigen in the presence of TLR4 ligand induces TCR\u03b1\u03b2+CD4+T contrasuppressor cells that reverse skin-induced suppression of Th1-mediated contact sensitivity","volume":"182","author":"Ptak","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.pharep.2018.02.015_bib0145","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.immuni.2006.01.001","article-title":"TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells","volume":"24","author":"Veldhoen","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.pharep.2018.02.015_bib0150","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1189\/jlb.1006610","article-title":"Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17","volume":"81","author":"Nakae","year":"2007","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.pharep.2018.02.015_bib0155","first-page":"939","article-title":"Reversal by cyclophosphamide of tolerance in contact sensitization: tolerance induced by prior feeding with DNCB","volume":"28","author":"Polak","year":"1975","journal-title":"Immunology"},{"key":"10.1016\/j.pharep.2018.02.015_bib0160","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0008-8749(79)90373-3","article-title":"Augmentation of specific tumor immunity against a syngeneic SV40-induced sarcoma in mice by retinoic acid","volume":"45","author":"Glaser","year":"1979","journal-title":"Cell Immunol"},{"key":"10.1016\/j.pharep.2018.02.015_bib0165","first-page":"3689","article-title":"Cyclophosphamide, doxorubicin, and paclitaxel enhance the antitumor immune response of granulocyte\/macrophage-colony stimulating factor-secreting whole-cell vaccines in HER-2\/neu tolerized mice","volume":"61","author":"Machiels","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.pharep.2018.02.015_bib0170","doi-asserted-by":"crossref","first-page":"09","DOI":"10.1097\/00002371-199607000-00006","article-title":"Enhancing the effect of THERATOPE STn-KLH cancer vaccine in patients with metastatic breast cancer by pretreatment with low-dose intravenous cyclophosphamide","volume":"19","author":"MacLean","year":"1996","journal-title":"J Immunother Emphasis Tumor Immunol"},{"key":"10.1016\/j.pharep.2018.02.015_bib0175","first-page":"3696","article-title":"Active immunotherapy of metastatic melanoma with allogeneic melanoma lysates and interferon \u03b1","volume":"8","author":"Vaishampayan","year":"2002","journal-title":"Clin Cancer Res"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114017301937?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114017301937?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:37:33Z","timestamp":1752611853000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1016\/j.pharep.2018.02.015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S1734114017301937"],"URL":"https:\/\/doi.org\/10.1016\/j.pharep.2018.02.015","relation":{},"ISSN":["1734-1140"],"issn-type":[{"type":"print","value":"1734-1140"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cyclophosphamide-modified murine peritoneal macrophages induce CD4+ T contrasuppressor cells that protect contact sensitivity T effector cells from suppression","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharep.2018.02.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}