{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:32:42Z","timestamp":1777710762385,"version":"3.51.4"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,23]],"date-time":"2019-03-23T00:00:00Z","timestamp":1553299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Specific University Research Grant"},{"name":"Ministry of Education, Youth and Sports of the Czech Republic"},{"name":"Faculty of Medicine MU"},{"name":"CETOCOEN PLUS"},{"name":"TACR GAMA"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Reports"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.pharep.2019.03.005","type":"journal-article","created":{"date-parts":[[2019,3,16]],"date-time":"2019-03-16T20:37:56Z","timestamp":1552768676000},"page":"669-675","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Oral administration of BDNF and\/or GDNF normalizes serum BDNF level in the olfactory bulbectomized rats: A proof of concept study"],"prefix":"10.1007","volume":"71","author":[{"given":"Jan","family":"Kucera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Ruda-Kucerova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filip","family":"Zlamal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Kuruczova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuzana","family":"Babinska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Tomandl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2944-9605","authenticated-orcid":false,"given":"Marie","family":"Tomandlova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5327-808X","authenticated-orcid":false,"given":"Julie","family":"Bienertova-Vasku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"10.1016\/j.pharep.2019.03.005_bib0005","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.neuropharm.2013.04.005","article-title":"BDNF-induced local protein synthesis and synaptic plasticity","volume":"76","author":"Leal","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharep.2019.03.005_bib0010","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neuroscience.2014.05.028","article-title":"Neurotrophins in the ventral tegmental area: role in social stress, mood disorders and drug abuse","volume":"282","author":"Nikulina","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharep.2019.03.005_bib0015","doi-asserted-by":"crossref","first-page":"298","DOI":"10.2174\/1389203716666150623104145","article-title":"Neurotrophin propeptides: biological functions and molecular mechanisms","volume":"17","author":"Rafieva","year":"2016","journal-title":"Curr Protein Pept Sci"},{"key":"10.1016\/j.pharep.2019.03.005_bib0020","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.neuropharm.2013.04.054","article-title":"Shaping neurons: long and short range effects of mature and proBDNF signalling upon neuronal structure","volume":"76","author":"Deinhardt","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharep.2019.03.005_bib0025","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.neuropharm.2013.05.029","article-title":"Form follows function: BDNF and its involvement in sculpting the function and structure of synapses","volume":"76","author":"Zagrebelsky","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharep.2019.03.005_bib0030","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.nbd.2016.01.021","article-title":"Biology of GDNF and its receptors\u2014relevance for disorders of the central nervous system","volume":"97","author":"Ib\u00e1\u00f1ez","year":"2017","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.pharep.2019.03.005_bib0035","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nrd3366","article-title":"Potential therapeutic uses of BDNF in neurological and psychiatric disorders","volume":"10","author":"Nagahara","year":"2011","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.pharep.2019.03.005_bib0040","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.pharmthera.2007.03.005","article-title":"Advances in small molecules promoting neurotrophic function","volume":"115","author":"Price","year":"2007","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.pharep.2019.03.005_bib0045","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1023\/A:1012117815460","article-title":"Carboxyl-directed pegylation of brain-derived neurotrophic factor markedly reduces systemic clearance with minimal loss of biologic activity","volume":"14","author":"Sakane","year":"1997","journal-title":"Pharm Res"},{"key":"10.1016\/j.pharep.2019.03.005_bib0050","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0169-409X(98)00086-6","article-title":"Penetration of neurotrophins and cytokines across the blood-brain\/blood-spinal cord barrier","volume":"36","author":"Pan","year":"1999","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.pharep.2019.03.005_bib0055","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/0169-328X(95)00250-V","article-title":"Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF","volume":"36","author":"Poduslo","year":"1996","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.pharep.2019.03.005_bib0060","doi-asserted-by":"crossref","first-page":"e21663","DOI":"10.1371\/journal.pone.0021663","article-title":"S100B protein, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor in human milk","volume":"6","author":"Li","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.pharep.2019.03.005_bib0065","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ijdevneu.2013.12.007","article-title":"Preeclampsia alters milk neurotrophins and long chain polyunsaturated fatty acids","volume":"33","author":"Dangat","year":"2014","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.pharep.2019.03.005_bib0070","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/(SICI)1097-4547(19960415)44:2<133::AID-JNR5>3.0.CO;2-E","article-title":"Combined effects of GDNF, BDNF, and CNTF on motoneuron differentiation in vitro","volume":"44","author":"Zurn","year":"1996","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.pharep.2019.03.005_bib0075","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0306-4522(97)00497-1","article-title":"Synergistic but transient rescue effects of BDNF and GDNF on axotomized neonatal motoneurons","volume":"84","author":"Vejsada","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharep.2019.03.005_bib0080","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ejphar.2014.10.033","article-title":"The olfactory bulbectomy model in mice and rat: one story or two tails?","volume":"753","author":"Hendriksen","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharep.2019.03.005_bib0085","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0006-8993(00)02619-6","article-title":"An in-vivo magnetic resonance imaging study of the olfactory bulbectomized rat model of depression","volume":"879","author":"Wrynn","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.pharep.2019.03.005_bib0090","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fphar.2014.00044","article-title":"Enhanced self-administration of the CB1 receptor agonist WIN55,212-2 in olfactory bulbectomized rats: evaluation of possible serotonergic and dopaminergic underlying mechanisms","volume":"5","author":"Amchova","year":"2014","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.pharep.2019.03.005_bib0095","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1037\/pha0000106","article-title":"Differential characteristics of ketamine self-administration in the olfactory bulbectomy model of depression in male rats","volume":"25","author":"Babinska","year":"2017","journal-title":"Exp Clin Psychopharmacol"},{"key":"10.1016\/j.pharep.2019.03.005_bib0100","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1017\/S1461145711001684","article-title":"The effects of methamphetamine self-administration on behavioural sensitization in the olfactory bulbectomy rat model of depression","volume":"15","author":"Kucerova","year":"2012","journal-title":"Int J Neuropsychol"},{"key":"10.1016\/j.pharep.2019.03.005_bib0105","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3109\/15622975.2015.1077991","article-title":"Reward related neurotransmitter changes in a model of depression: an in vivo microdialysis study","volume":"16","author":"Ruda-Kucerova","year":"2015","journal-title":"World J Biol Psychiatry"},{"key":"10.1016\/j.pharep.2019.03.005_bib0110","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0163-7258(97)00004-1","article-title":"The olfactory bulbectomized rat as a model of depression: an update","volume":"74","author":"Kelly","year":"1997","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.pharep.2019.03.005_bib0115","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.neubiorev.2005.03.010","article-title":"The olfactory bulbectomised rat as a model of depression","volume":"29","author":"Song","year":"2005","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pharep.2019.03.005_bib0120","first-page":"176","article-title":"Algorithm AS 181: the W test for normality","volume":"31","author":"Royston","year":"1982","journal-title":"J R Stat Soc Ser C (Appl Stat"},{"key":"10.1016\/j.pharep.2019.03.005_bib0125","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/biomet\/52.3-4.591","article-title":"An analysis of variance test for normality (complete samples)","volume":"52","author":"Shapiro","year":"1965","journal-title":"Biometrika"},{"key":"10.1016\/j.pharep.2019.03.005_bib0130","volume":"vol. 2","author":"Tukey","year":"1977"},{"key":"10.1016\/j.pharep.2019.03.005_bib0135","article-title":"Analysis of variance; designed experiments","volume":"vol. 251","author":"Chambers","year":"1992"},{"key":"10.1016\/j.pharep.2019.03.005_bib0140","series-title":"Practical data analysis for designed experiments","author":"Yandell","year":"1997"},{"key":"10.1016\/j.pharep.2019.03.005_bib0145","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1098\/rspa.1937.0109","article-title":"Properties of sufficiency and statistical tests","volume":"160","author":"Bartlett","year":"1937","journal-title":"Proc R Soc Lond A"},{"issue":"4","key":"10.1016\/j.pharep.2019.03.005_bib0150","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1027\/1614-2241\/a000016","article-title":"Is it really robust?","volume":"6","author":"Schmider","year":"2010","journal-title":"Methodology"},{"key":"10.1016\/j.pharep.2019.03.005_bib0155","series-title":"R: a language and environment for statistical computing","author":"R Development Core Team","year":"2016"},{"key":"10.1016\/j.pharep.2019.03.005_bib0160","doi-asserted-by":"crossref","first-page":"1537S","DOI":"10.1093\/ajcn\/77.6.1537S","article-title":"Nutritional and physiologic significance of human milk proteins","volume":"77","author":"L\u00f6nnerdal","year":"2003","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.pharep.2019.03.005_bib0165","first-page":"1","article-title":"S100b protein, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor in human milk","volume":"6","author":"Li","year":"2011","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.pharep.2019.03.005_bib0170","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1002\/mnfr.201100124","article-title":"Breast milk contains relevant neurotrophic factors and cytokines for enteric nervous system development","volume":"55","author":"Fichter","year":"2011","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.pharep.2019.03.005_bib0175","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1740-8709.2010.00252.x","article-title":"Neuro-developmental outcome and brain-derived neurotrophic factor level in relation to feeding practice in early infancy","volume":"7","author":"Nassar","year":"2011","journal-title":"Matern Child Nutr"},{"key":"10.1016\/j.pharep.2019.03.005_bib0180","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ijdevneu.2012.12.007","article-title":"Higher levels of brain derived neurotrophic factor but similar nerve growth factor in human milk in women with preeclampsia","volume":"31","author":"Dangat","year":"2013","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.pharep.2019.03.005_bib0185","doi-asserted-by":"crossref","first-page":"e61052","DOI":"10.1371\/journal.pone.0061052","article-title":"Suppression of neuroinflammatory and apoptotic signaling cascade by curcumin alone and in combination with piperine in rat model of olfactory bulbectomy induced depression","volume":"8","author":"Rinwa","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.pharep.2019.03.005_bib0190","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.physbeh.2014.02.037","article-title":"Panax quinquefolium involves nitric oxide pathway in olfactory bulbectomy rat model","volume":"129","author":"Rinwa","year":"2014","journal-title":"Physiol Behav"},{"key":"10.1016\/j.pharep.2019.03.005_bib0195","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/ejn.12406","article-title":"Fish oil improves anxiety-like, depressive-like and cognitive behaviors in olfactory bulbectomised rats","volume":"39","author":"Pudell","year":"2014","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pharep.2019.03.005_bib0200","first-page":"63","article-title":"Etazolate, a phosphodiesterase-4 enzyme inhibitor produces antidepressant-like effects by blocking the behavioral, biochemical, neurobiological deficits and histological abnormalities in hippocampus region caused by olfactory bulbectomy","volume":"105","author":"Jindal","year":"2014","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pharep.2019.03.005_bib0205","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s12035-014-8721-x","article-title":"REM sleep deprivation reverses neurochemical and other depressive-like alterations induced by olfactory bulbectomy","volume":"51","author":"Maturana","year":"2015","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.pharep.2019.03.005_bib0210","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.physbeh.2017.07.010","article-title":"Silymarin ameliorates experimentally induced depressive like behavior in rats: involvement of hippocampal BDNF signaling, inflammatory cytokines and oxidative stress response","volume":"179","author":"Thakare","year":"2017","journal-title":"Physiol Behav"},{"key":"10.1016\/j.pharep.2019.03.005_bib0215","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.neuropharm.2016.04.020","article-title":"Behavioral, neurochemical and molecular changes after acute deep brain stimulation of the infralimbic prefrontal cortex","volume":"108","author":"Jimenez-Sanchez","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharep.2019.03.005_bib0220","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0304-3940(02)00529-3","article-title":"Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets","volume":"328","author":"Karege","year":"2002","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pharep.2019.03.005_bib0225","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1017\/S1461145710000738","article-title":"Blood BDNF concentrations reflect brain-tissue BDNF levels across species","volume":"14","author":"Klein","year":"2011","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.pharep.2019.03.005_bib0230","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1523\/JNEUROSCI.5599-03.2004","article-title":"Induction of brain-derived neurotrophic factor in plaque-associated glial cells of aged APP23 transgenic mice","volume":"24","author":"Burbach","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharep.2019.03.005_bib0235","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3109\/00207454.2012.721829","article-title":"Expressions of brain-derived neurotrophic factor (BDNF) in cerebrospinal fluid and plasma of children with meningitis and encephalitis\/encephalopathy","volume":"123","author":"Morichi","year":"2013","journal-title":"Int J Neurosci"},{"key":"10.1016\/j.pharep.2019.03.005_bib0240","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1007\/s00702-005-0397-y","article-title":"Stage-dependent BDNF serum concentrations in Alzheimer\u2019s disease","volume":"113","author":"Laske","year":"2006","journal-title":"J Neural Transm"},{"key":"10.1016\/j.pharep.2019.03.005_bib0245","doi-asserted-by":"crossref","DOI":"10.1038\/srep33694","article-title":"Ultra-sensitive detection of brain-derived neurotrophic factor (BDNF) in the brain of freely moving mice using an interdigitated microelectrode (IME) biosensor","volume":"6","author":"Yoo","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.pharep.2019.03.005_bib0250","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1053\/jhep.2001.20793","article-title":"Human and rat hepatic stellate cells express neurotrophins and neurotrophin receptors","volume":"33","author":"Cassiman","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.pharep.2019.03.005_bib0255","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/S0002-9440(10)65221-2","article-title":"Abundant production of brain-derived neurotrophic factor by adult visceral epithelia. Implications for paracrine and target-derived neurotrophic functions","volume":"155","author":"Lommatzsch","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1016\/j.pharep.2019.03.005_bib0260","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1007\/s00125-009-1364-1","article-title":"Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase","volume":"52","author":"Matthews","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.pharep.2019.03.005_bib0265","doi-asserted-by":"crossref","first-page":"885","DOI":"10.2174\/138161207780414287","article-title":"Food-derived peptides and intestinal functions","volume":"13","author":"Shimizu","year":"2007","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.pharep.2019.03.005_bib0270","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/0304-4165(77)90323-3","article-title":"A tryptic digestion fragment of nerve growth factor with nerve growth promoting activity","volume":"496","author":"Mercanti","year":"1977","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.pharep.2019.03.005_bib0275","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1523\/JNEUROSCI.3360-15.2016","article-title":"AP-1 transcription factors mediate BDNF-Positive feedback loop in cortical neurons","volume":"36","author":"Tuvikene","year":"2016","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharep.2019.03.005_bib0280","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1084\/jem.189.5.865","article-title":"Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation?","volume":"189","author":"Kerschensteiner","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.pharep.2019.03.005_bib0285","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1097\/00001756-199805110-00038","article-title":"Rapid increase of NGF, BDNF and NT-3 mRNAs in inflamed bladder","volume":"9","author":"Oddiah","year":"1998","journal-title":"Neuroreport"},{"key":"10.1016\/j.pharep.2019.03.005_bib0290","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1164\/ajrccm.158.6.9803023","article-title":"Neurotrophins are increased in bronchoalveolar lavage fluid after segmental allergen provocation","volume":"158","author":"Virchow","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharep.2019.03.005_bib0295","first-page":"121","article-title":"Peripheral blood leukocyte production of BDNF following mitogen stimulation in early onset and regressive autism","volume":"4","author":"Enstrom","year":"2016","journal-title":"Am J Biochem Biotechnol"},{"key":"10.1016\/j.pharep.2019.03.005_bib0300","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/mnfr.200700312","article-title":"S100B Protein concentration in milk-formulas for preterm and term infants: correlation with industrial preparation procedures","volume":"52","author":"Nigro","year":"2008","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.pharep.2019.03.005_bib0305","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1080\/14767058.2017.1291618","article-title":"Holder pasteurization affects S100B concentrations in human milk","volume":"31","author":"Peila","year":"2018","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.pharep.2019.03.005_bib0310","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jaci.2009.05.038","article-title":"Intestinal barrier function: molecular regulation and disease pathogenesis","volume":"124","author":"Groschwitz","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pharep.2019.03.005_bib0315","doi-asserted-by":"crossref","DOI":"10.1038\/ctg.2016.54","article-title":"Human intestinal barrier function in health and disease","volume":"7","author":"K\u00f6nig","year":"2016","journal-title":"Clin Transl Gastroenterol"},{"key":"10.1016\/j.pharep.2019.03.005_bib0320","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.kjms.2017.11.002","article-title":"Brain-derived neurotrophic factor preserves intestinal mucosal barrier function and alters gut microbiota in mice","volume":"34","author":"Li","year":"2018","journal-title":"Kaohsiung J Med Sci"},{"key":"10.1016\/j.pharep.2019.03.005_bib0325","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/mnfr.201300204","article-title":"Protein transport across the small intestine in food allergy","volume":"58","author":"Reitsma","year":"2014","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.pharep.2019.03.005_bib0330","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0165-3806(82)90094-3","article-title":"Effects of oral administration of nerve growth factor and of its antiserum on sympathetic ganglia of neonatal mice","volume":"4","author":"Aloe","year":"1982","journal-title":"Brain Res"},{"key":"10.1016\/j.pharep.2019.03.005_bib0335","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1083\/jcb.103.5.1979","article-title":"Uptake and transepithelial transport of nerve growth factor in suckling rat ileum","volume":"103","author":"Siminoski","year":"1986","journal-title":"J Cell Biol"},{"key":"10.1016\/j.pharep.2019.03.005_bib0340","doi-asserted-by":"crossref","first-page":"10379","DOI":"10.1523\/JNEUROSCI.1042-14.2014","article-title":"Reduced intestinal brain-derived neurotrophic factor increases vagal sensory innervation of the intestine and enhances satiation","volume":"34","author":"Biddinger","year":"2014","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharep.2019.03.005_bib0345","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.mcn.2006.06.001","article-title":"The localization, trafficking and retrograde transport of BDNF bound to p75NTR in sympathetic neurons","volume":"32","author":"Hibbert","year":"2006","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.pharep.2019.03.005_bib0350","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/jb\/mvw037","article-title":"Retrograde transport of neurotrophic factor signaling: implications in neuronal development and pathogenesis","volume":"160","author":"Ito","year":"2016","journal-title":"J Biochem"},{"issue":"2","key":"10.1016\/j.pharep.2019.03.005_bib0355","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0306-4522(01)00093-8","article-title":"Glial cell line-derived neurotrophic factor promotes survival and induces differentiation through the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathway respectively in PC12 cells","volume":"104","author":"Chen","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharep.2019.03.005_bib0360","doi-asserted-by":"crossref","first-page":"7351","DOI":"10.1523\/JNEUROSCI.18-18-07351.1998","article-title":"The survival-promoting effect of glial cell line-derived neurotrophic factor on axotomized corticospinal neurons in vivo is mediated by an endogenous brain-derived neurotrophic factor mechanism","volume":"18","author":"Giehl","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharep.2019.03.005_bib0365","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1016\/j.bbamcr.2014.09.010","article-title":"Brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor inhibit ferrous iron influx via divalent metal transporter 1 and iron regulatory protein 1 regulation in ventral mesencephalic neurons","volume":"1843","author":"Zhang","year":"2014","journal-title":"Biochim Biophys Acta\u2014Mol Cell Res"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114018305516?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114018305516?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:37:57Z","timestamp":1752611877000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1016\/j.pharep.2019.03.005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":73,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S1734114018305516"],"URL":"https:\/\/doi.org\/10.1016\/j.pharep.2019.03.005","relation":{},"ISSN":["1734-1140"],"issn-type":[{"value":"1734-1140","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oral administration of BDNF and\/or GDNF normalizes serum BDNF level in the olfactory bulbectomized rats: A proof of concept study","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharep.2019.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier B.V. on behalf of Institute of Pharmacology, Polish Academy of Sciences.","name":"copyright","label":"Copyright"}]}}