{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:10:40Z","timestamp":1789679440307,"version":"4.0.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Reports"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.pharep.2019.04.018","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T11:23:43Z","timestamp":1556191423000},"page":"917-925","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Co-targeting of endothelin-A and vitamin D receptors: a novel strategy to ameliorate cisplatin-induced nephrotoxicity"],"prefix":"10.1007","volume":"71","author":[{"given":"Lobna M.","family":"Abdel Moneim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0375-6762","authenticated-orcid":false,"given":"Maged W.","family":"Helmy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan S.","family":"El-Abhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"10.1016\/j.pharep.2019.04.018_bib0005","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/sj.ki.5002786","article-title":"Cisplatin nephrotoxicity: mechanisms and renoprotective strategies","volume":"73","author":"Pabla","year":"2008","journal-title":"Kidney Int"},{"key":"10.1016\/j.pharep.2019.04.018_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/967826","article-title":"Pathophysiology of cisplatin-induced acute kidney injury","volume":"2014","author":"Ozkok","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.pharep.2019.04.018_bib0015","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.377","article-title":"MiR-30c regulates cisplatin-induced apoptosis of renal tubular epithelial cells by targeting Bnip3L and Hspa5","volume":"8","author":"Du","year":"2017","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.pharep.2019.04.018_bib0020","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00204-012-0821-7","article-title":"Cisplatin-induced nephrotoxicity and targets of nephroprotection: an update","volume":"86","author":"Dos Santos","year":"2012","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.pharep.2019.04.018_bib0025","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.3390\/toxins2112490","article-title":"Mechanisms of cisplatin nephrotoxicity","volume":"2","author":"Miller","year":"2010","journal-title":"Toxins"},{"key":"10.1016\/j.pharep.2019.04.018_bib0030","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4196\/kjpp.2008.12.4.149","article-title":"Expression of endothelin-1 and its receptors in cisplatin-induced acute renal failure in mice","volume":"12","author":"Lee","year":"2008","journal-title":"Korean J Physiol Pharmacol"},{"key":"10.1016\/j.pharep.2019.04.018_bib0035","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/sj.ki.5002009","article-title":"Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease","volume":"71","author":"Levin","year":"2007","journal-title":"Kidney Int"},{"key":"10.1016\/j.pharep.2019.04.018_bib0040","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.semnephrol.2013.07.005","article-title":"Vitamin D receptor signaling in renal and cardiovascular protection","volume":"33","author":"Li","year":"2013","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.pharep.2019.04.018_bib0045","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ejphar.2012.03.019","article-title":"Paricalcitol prevents cisplatin-induced renal injury by suppressing apoptosis and proliferation","volume":"683","author":"Park","year":"2012","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharep.2019.04.018_bib0050","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1681\/ASN.2007060666","article-title":"Paricalcitol inhibits renal inflammation by promoting vitamin D receptor\u2013mediated sequestration of NF-\u03baB signaling","volume":"19","author":"Tan","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.pharep.2019.04.018_bib0055","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/ndt\/gfl595","article-title":"Potential role of active vitamin D in retarding the progression of chronic kidney disease","volume":"22","author":"Tian","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.pharep.2019.04.018_bib0060","first-page":"266","article-title":"Identification and characterization of endothelin receptors on rat osteoblastic osteosarcoma cells: down-regulation by 1, 25-dihydroxy-vitamin D3","volume":"47","author":"Nambi","year":"1995","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.pharep.2019.04.018_bib0065","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1172\/JCI118582","article-title":"1, 25 (OH) 2 vitamin D3, and retinoic acid antagonize endothelin-stimulated hypertrophy of neonatal rat cardiac myocytes","volume":"97","author":"Wu","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharep.2019.04.018_bib0070","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ejphar.2014.03.002","article-title":"Selective ET A receptor blockade protects against cisplatin-induced acute renal failure in male rats","volume":"730","author":"Helmy","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharep.2019.04.018_bib0075","doi-asserted-by":"crossref","first-page":"4291","DOI":"10.1111\/bph.13199","article-title":"Endothelin ETA receptor\/lipid peroxides\/COX-2\/TGF-\u03b21 signalling underlies aggravated nephrotoxicity caused by cyclosporine plus indomethacin in rats","volume":"172","author":"Helmy","year":"2015","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharep.2019.04.018_bib0080","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1152\/japplphysiol.01407.2005","article-title":"Effects of chronic cold exposure on the endothelin system","volume":"100","author":"Chen","year":"2006","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.pharep.2019.04.018_bib0085","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1093\/ndt\/gfp117","article-title":"Active vitamin D and its analogue, 22-oxacalcitriol, ameliorate puromycin aminonucleoside-induced nephrosis in rats","volume":"24","author":"Matsui","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.pharep.2019.04.018_bib0090","first-page":"155","article-title":"Techniques of image analysis for quantitative immunohistochemistry","volume":"49","author":"Kaczmarek","year":"2004","journal-title":"Rocz Akad Med Bialymst."},{"key":"10.1016\/j.pharep.2019.04.018_bib0095","doi-asserted-by":"crossref","first-page":"145","DOI":"10.23876\/j.krcp.2017.36.2.145","article-title":"Paricalcitol attenuates lipopolysaccharide-induced inflammation and apoptosis in proximal tubular cells through the prostaglandin E2 receptor EP4","volume":"36","author":"Hong","year":"2017","journal-title":"Kidney Res Clin Pract"},{"key":"10.1016\/j.pharep.2019.04.018_bib0100","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.lfs.2014.01.078","article-title":"\u03b2-Arrestin 1 is required for endothelin-1-induced NF-\u03baB activation in ovarian cancer cells","volume":"118","author":"Cianfrocca","year":"2014","journal-title":"Life Sci"},{"key":"10.1016\/j.pharep.2019.04.018_bib0105","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ejphar.2018.04.032","article-title":"Role of Wnt4\/\u03b2-catenin, Ang II\/TGF\u03b2, ACE2, NF-\u03baB, and IL-18 in attenuating renal ischemia\/reperfusion-induced injury in rats treated with Vit D and pioglitazone","volume":"831","author":"Ali","year":"2018","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharep.2019.04.018_bib0110","doi-asserted-by":"crossref","first-page":"72","DOI":"10.2174\/1874312901206010072","article-title":"Suppl 1: new insights into the mechanisms of innate immune receptor signalling in fibrosis","volume":"6","author":"Lafyatis","year":"2012","journal-title":"Open Rheumatol J"},{"key":"10.1016\/j.pharep.2019.04.018_bib0115","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1365-2362.2006.01689.x","article-title":"Role of endothelin and endothelin receptor antagonists in renal disease","volume":"36","author":"Neuhofer","year":"2006","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.pharep.2019.04.018_bib0120","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0163-7258(01)00131-0","article-title":"Endothelins: vasoactive modulators of renal function in health and disease","volume":"90","author":"Naicker","year":"2001","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.pharep.2019.04.018_bib0125","doi-asserted-by":"crossref","first-page":"803","DOI":"10.3109\/10408444.2011.602662","article-title":"An integrative view of the pathophysiological events leading to cisplatin nephrotoxicity","volume":"41","author":"S\u00e1nchez-Gonz\u00e1lez","year":"2011","journal-title":"Crit Rev Toxicol"},{"key":"10.1016\/j.pharep.2019.04.018_bib0130","doi-asserted-by":"crossref","first-page":"18687","DOI":"10.1038\/srep18687","article-title":"Vitamin D3 pretreatment regulates renal inflammatory responses during lipopolysaccharide-induced acute kidney injury","volume":"5","author":"Xu","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.pharep.2019.04.018_bib0135","doi-asserted-by":"crossref","first-page":"19450","DOI":"10.1074\/jbc.M113.467670","article-title":"Vitamin D receptor inhibits nuclear factor \u03baB activation by interacting with I\u03baB kinase \u03b2 protein","volume":"288","author":"Chen","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharep.2019.04.018_bib0140","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1096\/fj.10-161612","article-title":"Endothelin-1 gene regulation","volume":"25","author":"Stow","year":"2011","journal-title":"FASEB J"},{"key":"10.1016\/j.pharep.2019.04.018_bib0145","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1681\/ASN.2006030208","article-title":"Endothelin A receptor blockade reduces diabetic renal injury via an anti-inflammatory mechanism","volume":"18","author":"Sasser","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.pharep.2019.04.018_bib0150","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1183\/09031936.00021411","article-title":"Bosentan inhibits cigarette smoke-induced endothelin receptor expression in pulmonary arteries","volume":"39","author":"Milara","year":"2012","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pharep.2019.04.018_bib0155","doi-asserted-by":"crossref","first-page":"R346","DOI":"10.1152\/ajpregu.00388.2015","article-title":"Vitamin D supplementation improves pathophysiology in a rat model of preeclampsia","volume":"310","author":"Faulkner","year":"2016","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.pharep.2019.04.018_bib0160","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1681\/ASN.2006050520","article-title":"Paricalcitol attenuates renal interstitial fibrosis in obstructive nephropathy","volume":"17","author":"Tan","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.pharep.2019.04.018_bib0165","doi-asserted-by":"crossref","first-page":"F272","DOI":"10.1152\/ajprenal.00352.2007","article-title":"Effects of \u03b1-lipoic acid on ischemia-reperfusion-induced renal dysfunction in rats","volume":"294","author":"Bae","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.pharep.2019.04.018_bib0170","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/ncpneph0891","article-title":"Reversal of proteinuric renal disease and the emerging role of endothelin","volume":"4","author":"Barton","year":"2008","journal-title":"Nat Clin Pract Nephrol"},{"key":"10.1016\/j.pharep.2019.04.018_bib0175","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1183\/09059180.00010907","article-title":"Role of endothelin in lung fibrosis","volume":"17","author":"Abraham","year":"2008","journal-title":"Eur Respir Rev"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114019300209?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114019300209?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:38:02Z","timestamp":1752611882000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1016\/j.pharep.2019.04.018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S1734114019300209"],"URL":"https:\/\/doi.org\/10.1016\/j.pharep.2019.04.018","relation":{},"ISSN":["1734-1140"],"issn-type":[{"value":"1734-1140","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Co-targeting of endothelin-A and vitamin D receptors: a novel strategy to ameliorate cisplatin-induced nephrotoxicity","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharep.2019.04.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}