{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T10:28:59Z","timestamp":1768991339346,"version":"3.49.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005297","name":"Medical University of Bia\u0142ystok","doi-asserted-by":"crossref","award":["N\/ST\/ZB\/17\/001\/1116"],"award-info":[{"award-number":["N\/ST\/ZB\/17\/001\/1116"]}],"id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Reports"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.pharep.2019.05.003","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T20:56:51Z","timestamp":1557521811000},"page":"892-898","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["The effects of extended nitric oxide release on responses of the human non-pregnant myometrium to endothelin-1 or vasopressin"],"prefix":"10.1007","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1051-7906","authenticated-orcid":false,"given":"Beata","family":"Modzelewska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9182-8791","authenticated-orcid":false,"given":"Maciej","family":"J\u00f3\u017awik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcin","family":"J\u00f3\u017awik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzena","family":"Tylicka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Kleszczewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"10.1016\/j.pharep.2019.05.003_bib0005","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/humupd\/dmq016","article-title":"Physiological pathways and molecular mechanisms regulating uterine contractility","volume":"16","author":"Aguilar","year":"2010","journal-title":"Hum Reprod Update"},{"issue":"Suppl 2","key":"10.1016\/j.pharep.2019.05.003_bib0010","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1472-6483(10)60450-6","article-title":"Uterine dynamics: impact on the human reproduction process","volume":"18","author":"Fanchin","year":"2009","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.pharep.2019.05.003_bib0015","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1095\/biolreprod.102.008367","article-title":"Contraction of cultured human uterine smooth muscle cells after stimulation with endothelin-1","volume":"68","author":"Dallot","year":"2003","journal-title":"Biol Reprod"},{"key":"10.1016\/j.pharep.2019.05.003_bib0020","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.biocel.2010.10.009","article-title":"Endothelin-1: physiological and pathological roles in myometrium","volume":"43","author":"Tanfin","year":"2011","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.pharep.2019.05.003_bib0025","first-page":"18","article-title":"Vasopressin and oxytocin in normal reproduction and in the pathophysiology of preterm labour and primary dysmenorrhoea. Development of receptor antagonists for therapeutic use in these conditions","volume":"49","author":"Akerlund","year":"2004","journal-title":"Rocz Akad Med w Bia\u0142ymstoku"},{"key":"10.1016\/j.pharep.2019.05.003_bib0030","doi-asserted-by":"crossref","first-page":"176","DOI":"10.2174\/1874467211104030176","article-title":"Modulators of the vascular endothelin receptor in blood pressure regulation and hypertension","volume":"4","author":"Khalil","year":"2011","journal-title":"Curr Mol Pharmacol"},{"key":"10.1016\/j.pharep.2019.05.003_bib0035","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/MNH.0b013e32835b4edc","article-title":"Nitric oxide and the A and B of endothelin of sodium homeostasis","volume":"22","author":"Hyndman","year":"2013","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.pharep.2019.05.003_bib0040","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/(SICI)1097-4652(199603)166:3<469::AID-JCP1>3.0.CO;2-N","article-title":"Regulation of endothelin receptors by nitric oxide in cultured rat vascular smooth muscle cells","volume":"166","author":"Redmond","year":"1996","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.pharep.2019.05.003_bib0045","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.neuroscience.2014.12.058","article-title":"Oxytocin-induced membrane hyperpolarization in pain-sensitive dorsal root ganglia neurons mediated by Ca2+\/nNOS\/NO\/KATP pathway","volume":"289","author":"Gong","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharep.2019.05.003_bib0050","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1097\/00005344-200312000-00002","article-title":"Endothelium-dependent, vasopressin-induced contractions in rabbit renal arteries","volume":"42","author":"Streefkerk","year":"2003","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.pharep.2019.05.003_bib0055","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1365-2826.2012.02303.x","article-title":"Oxytocin and vasopressin agonists and antagonists as research tools and potential therapeutics","volume":"24","author":"Manning","year":"2012","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.pharep.2019.05.003_bib0060","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/bjaceaccp\/mkn021","article-title":"Vasopressin and its role in critical care","volume":"8","author":"Sharman","year":"2008","journal-title":"Contin Educ Anaesth Crit Care Pain"},{"key":"10.1016\/j.pharep.2019.05.003_bib0065","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1161\/01.HYP.25.4.848","article-title":"Circulating nitric oxide (nitrite\/nitrate) levels in postmenopausal women substituted with 17\u03b2-estradiol and norethisterone acetate: a two-year follow-up study","volume":"25","author":"Rosselli","year":"1995","journal-title":"Hypertension"},{"key":"10.1016\/j.pharep.2019.05.003_bib0070","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1517\/14656566.9.11.1935","article-title":"Nitric oxide: new evidence for novel therapeutic indications","volume":"9","author":"Wimalawansa","year":"2008","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.pharep.2019.05.003_bib0075","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/sj.cr.7290133","article-title":"The role of nitric oxide in cancer","volume":"12","author":"Xu","year":"2002","journal-title":"Cell Res"},{"key":"10.1016\/j.pharep.2019.05.003_bib0080","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/sj.bjp.0704226","article-title":"NO-induced relaxation of labouring and non-labouring human myometrium is not mediated by cyclic GMP","volume":"134","author":"Buxton","year":"2001","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharep.2019.05.003_bib0085","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1177\/1933719111398141","article-title":"Additive inhibitory effects of progesterone and sodium nitroprusside on uterine contractility during pregnancy","volume":"18","author":"Orth","year":"2011","journal-title":"Reprod Sci"},{"key":"10.1016\/j.pharep.2019.05.003_bib0090","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0163-7258(96)00004-6","article-title":"Nitric oxide and the myometrium","volume":"70","author":"Norman","year":"1996","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.pharep.2019.05.003_bib0095","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000010254","article-title":"Activation of Ca2+-Activated K+ channels in human myometrium by nitric oxide","volume":"49","author":"Shimano","year":"2000","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.pharep.2019.05.003_bib0100","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1006\/bbrc.1998.9844","article-title":"Involvement of K+ATP channels in nitric oxide-induced inhibition of spontaneous contractile activity of the nonpregnant human myometrium","volume":"253","author":"Modzelewska","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.pharep.2019.05.003_bib0105","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/00003246-200201000-00014","article-title":"Inhaled nitric oxide increases endothelin-1 levels: a potential cause of rebound pulmonary hypertension","volume":"30","author":"Pearl","year":"2002","journal-title":"Crit Care Med"},{"key":"10.1016\/j.pharep.2019.05.003_bib0110","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1172\/JCI114477","article-title":"Release of endothelin from the porcine aorta. Inhibition of endothelium-derived nitric oxide","volume":"85","author":"Boulanger","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharep.2019.05.003_bib0115","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00408-003-1046-6","article-title":"Protein kinase C modulation of cyclic GMP in rat neonatal pulmonary vascular smooth muscle","volume":"182","author":"Johnson","year":"2004","journal-title":"Lung"},{"key":"10.1016\/j.pharep.2019.05.003_bib0120","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ijgo.2005.04.018","article-title":"Plasma nitric oxide, endothelin-1 and urinary nitric oxide and cyclic guanosine monophosphate levels in hypertensive pregnant women","volume":"90","author":"Baksu","year":"2005","journal-title":"Int J Gynecol Obstet"},{"key":"10.1016\/j.pharep.2019.05.003_bib0125","doi-asserted-by":"crossref","first-page":"E535","DOI":"10.1152\/ajpendo.00344.2003","article-title":"Regulation of vasopressin secretion by ETA and ETB receptors in compartmentalized rat hypothalamo-neurohypophysial explants","volume":"286","author":"Rossi","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.pharep.2019.05.003_bib0130","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.vph.2007.09.003","article-title":"Effect of nitric oxide on responses of the human uterine arteries to vasopressin","volume":"48","author":"Kostrzewska","year":"2008","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.pharep.2019.05.003_bib0135","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s12576-016-0500-1","article-title":"Altered uterine contractility in response to \u03b2-adrenoceptor agonists in ovarian cancer","volume":"67","author":"Modzelewska","year":"2017","journal-title":"J Physiol Sci"},{"key":"10.1016\/j.pharep.2019.05.003_bib0140","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0076-6879(02)59174-6","article-title":"Guide for the use of nitric oxide (NO) donors as probes of the chemistry of NO and related redox species in biological systems","volume":"359","author":"Thomas","year":"2002","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.pharep.2019.05.003_bib0145","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0028-2243(95)02096-B","article-title":"Relaxant effects of nitric oxide and cyclic GMP on pregnant rat uterine longitudinal smooth muscle","volume":"60","author":"Izumi","year":"1995","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.pharep.2019.05.003_bib0150","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1023\/A:1023228925137","article-title":"Estimation of confidence intervals for area under the curve from destructively obtained pharmacokinetic data","volume":"26","author":"Gagnon","year":"1998","journal-title":"J Pharmacokinet Biopharm"},{"key":"10.1016\/j.pharep.2019.05.003_bib0155","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1006\/bbrc.1998.9844","article-title":"Involvement of K+ ATP channels in nitric oxide-induced inhibition of spontaneous contractile activity of the nonpregnant human myometrium","volume":"253","author":"Modzelewska","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.pharep.2019.05.003_bib0160","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/molehr\/gah072","article-title":"Roles of endogenous nitric oxide synthase inhibitors and endothelin-1 for regulating myometrial contractions during gestation in the rat","volume":"10","author":"Momohara","year":"2004","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.pharep.2019.05.003_bib0165","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1095\/biolreprod46.4.680","article-title":"Effects of endothelin and relaxin on rat uterine segment contractility","volume":"46","author":"McGovern","year":"1992","journal-title":"Biol Reprod"},{"key":"10.1016\/j.pharep.2019.05.003_bib0170","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.jsgi.2004.02.008","article-title":"Inhibitory effect of barusiban and atosiban on oxytocin-induced contractions of myometrium from preterm and term pregnant women","volume":"11","author":"Pierzynski","year":"2004","journal-title":"J Soc Gynecol Investig"},{"key":"10.1016\/j.pharep.2019.05.003_bib0175","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/GRF.0b013e31816d2307","article-title":"Evaluation and management of dysmenorrhea in adolescents","volume":"51","author":"Sanfilippo","year":"2008","journal-title":"Clin Obstet Gynecol"},{"issue":"Suppl 1","key":"10.1016\/j.pharep.2019.05.003_bib0180","article-title":"Cyclic AMP signalling pathways in the regulation of uterine relaxation","volume":"7","author":"Yuan","year":"2007","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.pharep.2019.05.003_bib0185","doi-asserted-by":"crossref","first-page":"504","DOI":"10.17772\/gp\/57835","article-title":"Have we achieved progress in tocolytic treatment? - results of a retrospective cohort study in a tertiary university hospital","volume":"86","author":"Tomczyk","year":"2015","journal-title":"Ginekol Pol"},{"key":"10.1016\/j.pharep.2019.05.003_bib0190","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ejphar.2011.09.034","article-title":"In vitro and in vivo pharmacological characterisation of the potent and selective vasopressin V(1A) receptor antagonist 4-[4-(4-Chloro-phenyl)-5-[1,2,3]triazol-2-ylmethyl-4H-[1,2,4]triazol-3-yl]-piperidin-1-yl-(3,5-difluoro-phenyl) methanone (PF-00738245)","volume":"670","author":"Russell","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharep.2019.05.003_bib0195","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/S0140-6736(08)60695-9","article-title":"Non-peptide arginine-vasopressin antagonists: the vaptans","volume":"371","author":"Decaux","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.pharep.2019.05.003_bib0200","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0014-2999(95)00388-2","article-title":"Endothelin ETA receptors mediate human uterine smooth muscle contraction","volume":"285","author":"H\u00e9luy","year":"1995","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharep.2019.05.003_bib0205","doi-asserted-by":"crossref","first-page":"C1668","DOI":"10.1152\/ajpcell.1998.275.6.C1668","article-title":"Nitric oxide relaxes human myometrium by a cGMP-independent mechanism","volume":"275","author":"Bradley","year":"1998","journal-title":"Am J Physiol Physiol"},{"key":"10.1016\/j.pharep.2019.05.003_bib0210","first-page":"1","article-title":"What is it about the uterus anyway?","volume":"46","author":"Buxton","year":"2003","journal-title":"Proc West Pharmacol Soc"},{"key":"10.1016\/j.pharep.2019.05.003_bib0215","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.lfs.2017.09.042","article-title":"Lignocaine augments the in-vitro uterine contractions involving NO-guanylyl cyclase dependent mechanisms","volume":"190","author":"Raheja","year":"2017","journal-title":"Life Sci"},{"key":"10.1016\/j.pharep.2019.05.003_bib0220","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.niox.2014.07.002","article-title":"Nitrosothiol signaling and protein nitrosation in cell death","volume":"42","author":"Iyer","year":"2014","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.pharep.2019.05.003_bib0225","first-page":"33","article-title":"The contribution of N\u2082O\u2083 to the cytotoxicity of the nitric oxide donor DETA\/NO: an emerging role for S-nitrosylation","author":"Ali","year":"2013","journal-title":"Biosci Rep"},{"key":"10.1016\/j.pharep.2019.05.003_bib0230","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/CIRCULATIONAHA.107.753467","article-title":"Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide","volume":"117","author":"Li","year":"2008","journal-title":"Circulation"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114019300246?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114019300246?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:38:03Z","timestamp":1752611883000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1016\/j.pharep.2019.05.003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S1734114019300246"],"URL":"https:\/\/doi.org\/10.1016\/j.pharep.2019.05.003","relation":{},"ISSN":["1734-1140"],"issn-type":[{"value":"1734-1140","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of extended nitric oxide release on responses of the human non-pregnant myometrium to endothelin-1 or vasopressin","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharep.2019.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}