{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T18:23:49Z","timestamp":1776277429502,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Reports"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.pharep.2019.05.005","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T11:49:48Z","timestamp":1557834588000},"page":"926-928","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Altered surface expression of P2Y11 receptor with narcolepsy-associated mutations"],"prefix":"10.1007","volume":"71","author":[{"given":"Maja Wallentin","family":"Dommer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Dreisig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitte Rahbek","family":"Kornum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"10.1016\/j.pharep.2019.05.005_bib0005","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0896-6273(00)00058-1","article-title":"Reduced number of hypocretin neurons in human narcolepsy","volume":"27","author":"Thannickal","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.pharep.2019.05.005_bib0010","first-page":"81","article-title":"The hypocretin\/orexin system in sleep disorders: preclinical insights and clinical progress","volume":"8","author":"Chow","year":"2016","journal-title":"Nat Sci Sleep"},{"key":"10.1016\/j.pharep.2019.05.005_bib0015","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/sleep\/32.8.979","article-title":"Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset","volume":"32","author":"Aran","year":"2009","journal-title":"Sleep"},{"key":"10.1016\/j.pharep.2019.05.005_bib0020","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/ana.22587","article-title":"Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China","volume":"70","author":"Han","year":"2011","journal-title":"Ann Neurol"},{"key":"10.1016\/j.pharep.2019.05.005_bib0025","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.vaccine.2012.12.015","article-title":"The incidence of narcolepsy in Europe: before, during, and after the influenza A(H1N1)pdm09 pandemic and vaccination campaigns","volume":"31","author":"Wijnans","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.pharep.2019.05.005_bib0030","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1093\/sleep\/33.7.869","article-title":"Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are associated with recent onset of cataplexy","volume":"33","author":"Kawashima","year":"2010","journal-title":"Sleep"},{"key":"10.1016\/j.pharep.2019.05.005_bib0035","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/ng.372","article-title":"Narcolepsy is strongly associated with the T-cell receptor alpha locus","volume":"41","author":"Hallmayer","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.pharep.2019.05.005_bib0040","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1086\/318799","article-title":"Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups","volume":"68","author":"Mignot","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.pharep.2019.05.005_bib0045","doi-asserted-by":"crossref","DOI":"10.1007\/s11302-016-9514-7","article-title":"A critical look at the function of the P2Y11 receptor","author":"Dreisig","year":"2016","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.pharep.2019.05.005_bib0050","doi-asserted-by":"crossref","first-page":"31969","DOI":"10.1074\/jbc.272.51.31969","article-title":"Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase","volume":"272","author":"Communi","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharep.2019.05.005_bib0055","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1093\/brain\/awx093","article-title":"Rare missense mutations in P2RY11 in narcolepsy with cataplexy","volume":"140","author":"Degn","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.pharep.2019.05.005_bib0060","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/ng.734","article-title":"Common variants in P2RY11 are associated with narcolepsy","volume":"43","author":"Kornum","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.pharep.2019.05.005_bib0065","doi-asserted-by":"crossref","first-page":"19","DOI":"10.5665\/sleep.3300","article-title":"DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe","volume":"37","author":"Tafti","year":"2014","journal-title":"Sleep"},{"key":"10.1016\/j.pharep.2019.05.005_bib0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003880","article-title":"Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic","volume":"9","author":"Han","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1016\/j.pharep.2019.05.005_bib0075","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/eurheartj\/ehl410","article-title":"Increased risk of acute myocardial infarction and elevated levels of C-reactive protein in carriers of the Thr-87 variant of the ATP receptor P2Y11","volume":"28","author":"Amisten","year":"2007","journal-title":"Eur Hear J"},{"key":"10.1016\/j.pharep.2019.05.005_bib0080","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.3389\/fimmu.2018.01159","article-title":"Human P2Y11 expression level affects human P2X7 receptor-mediated cell death","volume":"9","author":"Dreisig","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.pharep.2019.05.005_bib0085","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1124\/jpet.113.206276","article-title":"Delineation of the GPRC6A receptor signaling pathways using a mammalian cell line stably expressing the receptor","volume":"347","author":"Jacobsen","year":"2013","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pharep.2019.05.005_bib0090","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1089\/scd.2010.0295","article-title":"Regulation of human mesenchymal stem cell functions by an autocrine loop involving NAD+ release and P2Y11-mediated signaling","volume":"20","author":"Fruscione","year":"2011","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.pharep.2019.05.005_bib0095","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ejphar.2013.02.020","article-title":"Involvement of P2Y(1)(1) receptor in IFN-gamma-induced IL-6 production in human keratinocytes","volume":"703","author":"Ishimaru","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharep.2019.05.005_bib0100","doi-asserted-by":"crossref","first-page":"8544","DOI":"10.4049\/jimmunol.179.12.8544","article-title":"Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor","volume":"179","author":"Vaughan","year":"2007","journal-title":"J Immunol"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114019301094?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1734114019301094?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:38:03Z","timestamp":1752611883000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1016\/j.pharep.2019.05.005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S1734114019301094"],"URL":"https:\/\/doi.org\/10.1016\/j.pharep.2019.05.005","relation":{},"ISSN":["1734-1140"],"issn-type":[{"value":"1734-1140","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered surface expression of P2Y11 receptor with narcolepsy-associated mutations","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharep.2019.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}