{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T07:33:21Z","timestamp":1772350401000,"version":"3.50.1"},"reference-count":55,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annales Pharmaceutiques Fran\u00e7aises"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.pharma.2016.07.002","type":"journal-article","created":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T20:30:07Z","timestamp":1471984207000},"page":"453-462","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Antioxidant activity and total phenolic and flavonoids content variations of leaves extracts of white Horehound (Marrubium vulgare Linn\u00e9) from three geographical origins"],"prefix":"10.1016","volume":"74","author":[{"given":"K.","family":"Bouterfas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Mehdadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.M.","family":"Elaoufi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Latreche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Benchiha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharma.2016.07.002_bib0280","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1753-4887.1999.tb06933.x","article-title":"Establishing the significance and optimal intake of dietary antioxidants: the biomarker concept","volume":"57","author":"Halliwell","year":"1999","journal-title":"Nutr Rev"},{"key":"10.1016\/j.pharma.2016.07.002_bib0285","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2298\/ABS1401307A","article-title":"Antioxidant activity and total phenolic and flavonoid contents of Salvia amplexicaulis Lam. extracts","volume":"66","author":"Alimpic","year":"2014","journal-title":"Arch Biol Sci"},{"key":"10.1016\/j.pharma.2016.07.002_bib0290","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/BF01197931","article-title":"Toxicology of the synthetic antioxidants BHA and BHT in comparison with the natural antioxidant vitamin E","volume":"196","author":"Kahl","year":"1993","journal-title":"Z Lebensm Unters Forsch"},{"key":"10.1016\/j.pharma.2016.07.002_bib0295","doi-asserted-by":"crossref","first-page":"7313","DOI":"10.3390\/molecules15107313","article-title":"Plant phenolics: extraction, analysis, and their antioxidant and anticancer properties","volume":"15","author":"Dai","year":"2010","journal-title":"Molecules"},{"key":"10.1016\/j.pharma.2016.07.002_bib0300","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.4314\/tjpr.v7i3.14693","article-title":"Flavonoids as nutraceuticals: a review","volume":"7","author":"Tapas","year":"2008","journal-title":"Trop J Pharm Res"},{"key":"10.1016\/j.pharma.2016.07.002_bib0305","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1039\/b604521a","article-title":"Synthesis and immunosuppressive activity of L.\u00a0rhamnopyranosyl flavonoids","volume":"4","author":"Yang","year":"2006","journal-title":"Org Biomol Chem"},{"key":"10.1016\/j.pharma.2016.07.002_bib0310","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/S0305-1978(03)00040-1","article-title":"External leaf flavonoids of Thymus species from Macedonia","volume":"31","author":"Marin","year":"2003","journal-title":"Biochem Syst Ecol"},{"key":"10.1016\/j.pharma.2016.07.002_bib0315","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0031-6997(24)01472-8","article-title":"The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer","volume":"52","author":"Middleton","year":"2000","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.pharma.2016.07.002_bib0320","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0031-9422(03)00300-5","article-title":"Evolution of secondary metabolites from an ecological and molecular phylogenetic perspective","volume":"64","author":"Wink","year":"2003","journal-title":"Phytochemistry"},{"key":"10.1016\/j.pharma.2016.07.002_bib0325","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1080\/10412905.2006.9699116","article-title":"Essential oil composition and glandular trichomes of Marrubium vulgare L.\u00a0growing wild in Algeria","volume":"18","author":"Belhattab","year":"2006","journal-title":"J Essent Oil Res"},{"key":"10.1016\/j.pharma.2016.07.002_bib0330","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.fitote.2011.11.005","article-title":"Compositional analysis and in vivo anti-diabetic activity of wild Algerian Marrubium vulgare L. infusion","volume":"83","author":"Boudjelal","year":"2012","journal-title":"Fitoterapia"},{"key":"10.1016\/j.pharma.2016.07.002_bib0335","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ijdm.2011.01.004","article-title":"Hyperglycemia and dyslipidemia in streptozotocin-induced diabetic rats","volume":"3","author":"Elberry","year":"2015","journal-title":"Int J Diabetes Mellitus"},{"key":"10.1016\/j.pharma.2016.07.002_bib0340","first-page":"3908","article-title":"Chemical composition and antioxidant activity of Marrubium vulgare L.\u00a0essential oil from Tunisia","volume":"10","author":"Kadri","year":"2011","journal-title":"Afr J Biotechnol"},{"key":"10.1016\/j.pharma.2016.07.002_bib0345","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.indcrop.2014.06.049","article-title":"Phytochemical profiling, in vitro evaluation of total phenolic contents and antioxidant properties of Marrubium vulgare (horehound) leaves of plants growing in Algeria","volume":"61","author":"Amessis-Ouchemoukh","year":"2014","journal-title":"Industr Crops Prod"},{"key":"10.1016\/j.pharma.2016.07.002_bib0350","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1365-2621.2011.02801.x","article-title":"Temperature and storage effects on antioxidant activity of juice from red and white grapes","volume":"47","author":"Genova","year":"2012","journal-title":"Int J Food Sci Technol"},{"key":"10.1016\/j.pharma.2016.07.002_bib0355","series-title":"Nouvel flore de l\u2019Alg\u00e9rie et des r\u00e9gions d\u00e9sertiques m\u00e9ridionales","author":"Quezel","year":"1963"},{"key":"10.1016\/j.pharma.2016.07.002_bib0360","series-title":"Techniques of flavonoid identification","author":"Markham","year":"1982"},{"key":"10.1016\/j.pharma.2016.07.002_bib0365","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/0031-9422(94)00578-H","article-title":"Five 8-C benzylated flavonoids from Thymus hirtus (Labiateae)","volume":"38","author":"Merghem","year":"1995","journal-title":"Phytochemistry"},{"key":"10.1016\/j.pharma.2016.07.002_bib0370","first-page":"61","article-title":"Phytochemical screening of an ibero-morrocan endemic, Thymelaea lythroides","volume":"142","author":"Dohou","year":"2003","journal-title":"Bull Soc Pharm"},{"key":"10.1016\/j.pharma.2016.07.002_bib0375","first-page":"220","article-title":"Antifungal activity of different cinnamon extracts","volume":"15","author":"Senhadji","year":"2005","journal-title":"J Mycol Med"},{"key":"10.1016\/j.pharma.2016.07.002_bib0380","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.lwt.2007.03.011","article-title":"Antioxidant properties in vitro and total phenolic contents in methanol extracts from medicinal plants","volume":"41","author":"Li","year":"2008","journal-title":"LWT Food Sci Technol"},{"key":"10.1016\/j.pharma.2016.07.002_bib0385","first-page":"571","article-title":"Effect of ethanol concentration, extraction time and extraction temperature on the recovery of phenolic compounds and antioxidant capacity of Centella asiatica extracts","volume":"18","author":"Chew","year":"2011","journal-title":"Int Food Res J"},{"key":"10.1016\/j.pharma.2016.07.002_bib0390","first-page":"557","article-title":"Antioxidant properties: effects of solid-to-solvent ratio on antioxidant compounds and capacities of Pegaga (Centella asiatica)","volume":"18","author":"Tan","year":"2011","journal-title":"Int Food Res J"},{"key":"10.1016\/j.pharma.2016.07.002_bib0395","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.crci.2009.02.004","article-title":"Antioxidant activity of methanolic extracts and some bioactive compounds of Atriplex halimus","volume":"12","author":"Benhammou","year":"2009","journal-title":"C R Chim"},{"key":"10.1016\/j.pharma.2016.07.002_bib0400","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s11738-013-1397-4","article-title":"Variation in antioxidant activity and phenolic content in different organs of two Tunisian cultivars of Olea europaea L","volume":"36","author":"Brahmi","year":"2014","journal-title":"Acta Physiol Plant"},{"key":"10.1016\/j.pharma.2016.07.002_bib0405","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jembe.2007.05.028","article-title":"Influence of day-night and tidal cycles on phenol content and antioxidant capacity in three temperate intertidal brown seaweeds","volume":"349","author":"Connam","year":"2007","journal-title":"J Exp Mar Biol Ecol"},{"key":"10.1016\/j.pharma.2016.07.002_bib0410","first-page":"1067","article-title":"Effect of solvent extraction on antioxidant and antibacterial activities from Quercus infectoria (Manjakani)","volume":"21","author":"Syukriah","year":"2014","journal-title":"Int Food Res J"},{"key":"10.1016\/j.pharma.2016.07.002_bib0415","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.3390\/molecules18022328","article-title":"Techniques for analysis of plant phenolic compounds","volume":"18","author":"Khoddami","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.pharma.2016.07.002_bib0420","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-1-60327-029-8_5","article-title":"Phenolic acids and flavonoids: occurrence and analytical methods","volume":"610","author":"Stalikas","year":"2010","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.pharma.2016.07.002_bib0425","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.foodchem.2007.05.068","article-title":"In vitro and in vivo antioxidant activity of aqueous extract from Choerospondias axillaris fruit","volume":"106","author":"Wang","year":"2008","journal-title":"Food Chem"},{"key":"10.1016\/j.pharma.2016.07.002_bib0430","first-page":"3354","article-title":"Effect of extraction solvents on the phenolic content and antioxidant properties of two papaya cultivars","volume":"7","author":"Addai","year":"2013","journal-title":"J Med Plants Res"},{"key":"10.1016\/j.pharma.2016.07.002_bib0435","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.foodchem.2008.12.005","article-title":"Antioxidant capacity and phenolic content of selected tropical fruits from Malaysia, extracted with different solvents","volume":"115","author":"Alothman","year":"2009","journal-title":"Food Chem"},{"key":"10.1016\/j.pharma.2016.07.002_bib0440","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10298-014-0832-z","article-title":"Evaluation of the antioxidant and antimicrobial activities of the leaves and flowered tops of Marrubium vulgare L","volume":"12","author":"Ghedadba","year":"2014","journal-title":"Phytotherapie"},{"key":"10.1016\/j.pharma.2016.07.002_bib0445","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.foodchem.2011.07.112","article-title":"Isolation, identification and activity of natural antioxidants from horehound (Marrubium vulgare L.) cultivated in Lithuania","volume":"130","author":"Pukalskas","year":"2012","journal-title":"Food Chem"},{"key":"10.1016\/j.pharma.2016.07.002_bib0450","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.indcrop.2010.07.005","volume":"32","author":"Orhan","year":"2010","journal-title":"Industr Crops Prod"},{"key":"10.1016\/j.pharma.2016.07.002_bib0455","series-title":"Phenolic compound chemistry","author":"Vermerris","year":"2006"},{"key":"10.1016\/j.pharma.2016.07.002_bib0460","doi-asserted-by":"crossref","first-page":"621","DOI":"10.12691\/jfnr-2-9-15","article-title":"Effect of solvents on the antioxidant activity of walnut (Juglans regia L.) shell extracts","volume":"2","author":"Yang","year":"2014","journal-title":"J Food Nutr Res"},{"key":"10.1016\/j.pharma.2016.07.002_bib0465","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.foodchem.2008.08.008","article-title":"DPPH antioxidant assay revisited","volume":"113","author":"Sharma","year":"2009","journal-title":"Food Chem"},{"key":"10.1016\/j.pharma.2016.07.002_bib0470","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.aca.2004.11.010","article-title":"Standarization of antioxidant properties of honey by a combination of spectrophotometric\/fluorimetric assays and chemometrics","volume":"533","author":"Beretta","year":"2005","journal-title":"Anal Chim Acta"},{"key":"10.1016\/j.pharma.2016.07.002_bib0475","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.foodres.2011.12.009","article-title":"Fruiting body, spores and in vitro produced mycelium of Ganoderma lucidum from Northeast Portugal: a comparative study of the antioxidant potential of phenolic and polysaccharidic extracts","volume":"46","author":"Heleno","year":"2012","journal-title":"Food Res Int"},{"key":"10.1016\/j.pharma.2016.07.002_bib0480","first-page":"232","article-title":"Effect of phenological stage and geographical location on antioxidant activities of Tunisian horehound: Marrubium vulgare L.\u00a0(Lamiaceae)","volume":"2","author":"Chouaieb","year":"2012","journal-title":"J Biol Active Prod Nat"},{"issue":"4","key":"10.1016\/j.pharma.2016.07.002_bib0485","first-page":"140","article-title":"The effects of blanching, harvest time and location (with a minor look at postharvest blighting) on oleoresin yields, percent curcuminoids and levels of antioxidant activity of turmeric (Curcuma longa) rhizomes grown in Jamaica","author":"Green","year":"2014","journal-title":"Mod Chem Appl"},{"key":"10.1016\/j.pharma.2016.07.002_bib0490","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/jsfa.4654","article-title":"Variations in antioxidant properties of strawberries grown in Brazilian savannah and harvested in different seasons","volume":"92","author":"Pineli","year":"2012","journal-title":"J Sci Food Agric"},{"key":"10.1016\/j.pharma.2016.07.002_bib0495","first-page":"86","article-title":"Effect of geographical provenance on the physico-chemical, antioxidant characteristics and sensory evaluation of chestnut honeys","volume":"3","author":"Perna","year":"2014","journal-title":"Int J Food Sci Nutr"},{"key":"10.1016\/j.pharma.2016.07.002_bib0500","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.foodchem.2010.04.003","article-title":"Effect of drying method on the antioxidant capacity of six Larniaceae herbs","volume":"123","author":"Hossain","year":"2010","journal-title":"Food Chem"},{"key":"10.1016\/j.pharma.2016.07.002_bib0505","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.fertnstert.2009.03.041","article-title":"Attenuation of ischemia-reperfusion injury with Marrubium cordatum treatment in ovarian torsion-detorsion model in rabbits","volume":"93","author":"Cigremis","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.pharma.2016.07.002_bib0510","first-page":"63","article-title":"Total phenolic content, flavonoid concentration and antioxidant activity of Marrubium peregrinum L.\u00a0extracts","volume":"33","author":"Stankovic","year":"2011","journal-title":"Kragujevac J Sci"},{"key":"10.1016\/j.pharma.2016.07.002_bib0515","first-page":"227","article-title":"Comparative studies on antioxidant activity of methanol extract and flavonoid fraction of Nyctanthes arbortristis leaves","volume":"9","author":"Sasikumar","year":"2010","journal-title":"Electron J Environ Agric Food Chem"},{"key":"10.1016\/j.pharma.2016.07.002_bib0520","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1016\/j.fct.2011.07.042","article-title":"Evaluation to the antioxidant activity of total flavonoids extract from persimmon (Diospyros kaki L.) leaves","volume":"49","author":"Sun","year":"2011","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.pharma.2016.07.002_bib0525","doi-asserted-by":"crossref","first-page":"11281","DOI":"10.3390\/molecules170911281","article-title":"In vitro antioxidant properties of flavonoids and polysaccharides extract from Tobacco (Nicotiana tabacum L.) leaves","volume":"17","author":"Ru","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.pharma.2016.07.002_bib0530","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.foodres.2009.04.009","article-title":"HPLC-analysis of polyphenolic compounds in Spanish white wines and determination of their antioxidant activity by radical scavenging assay","volume":"42","author":"Rodriguez-Bernaldo","year":"2009","journal-title":"Food Res Int"},{"key":"10.1016\/j.pharma.2016.07.002_bib0535","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1016\/j.phytochem.2006.07.002","article-title":"Structure-radical scavenging activity relationships of flavonoids","volume":"67","author":"Seyoum","year":"2006","journal-title":"Phytochemistry"},{"key":"10.1016\/j.pharma.2016.07.002_bib0540","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.foodchem.2006.07.026","article-title":"Synthesis and evalution of new phenolic-based antioxidant: structure-activity relationship","volume":"103","author":"De Pinedo","year":"2007","journal-title":"Food Chem"},{"key":"10.1016\/j.pharma.2016.07.002_bib0545","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.foodchem.2006.01.004","article-title":"The antioxidant and free radical scavenging activities of processed cowpea (Vigna unguiculata (L.) Walp.) seed extracts","volume":"101","author":"Siddhuraju","year":"2007","journal-title":"Food Chem"},{"key":"10.1016\/j.pharma.2016.07.002_bib0550","first-page":"55","article-title":"Structure-radical scavenging activity relationships of flavonoids","volume":"76","author":"Amic","year":"2003","journal-title":"Croat Chem Acta"}],"container-title":["Annales Pharmaceutiques Fran\u00e7aises"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003450916300608?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003450916300608?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T23:32:23Z","timestamp":1757719943000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003450916300608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":55,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S0003450916300608"],"URL":"https:\/\/doi.org\/10.1016\/j.pharma.2016.07.002","relation":{},"ISSN":["0003-4509"],"issn-type":[{"value":"0003-4509","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antioxidant activity and total phenolic and flavonoids content variations of leaves extracts of white Horehound (Marrubium vulgare Linn\u00e9) from three geographical origins","name":"articletitle","label":"Article Title"},{"value":"Annales Pharmaceutiques Fran\u00e7aises","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharma.2016.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Acad\u00e9mie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}