{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:19:25Z","timestamp":1785575965411,"version":"3.56.0"},"reference-count":63,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004621","name":"Kerman University of Medical Sciences","doi-asserted-by":"publisher","award":["99000671"],"award-info":[{"award-number":["99000671"]}],"id":[{"id":"10.13039\/501100004621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annales Pharmaceutiques Fran\u00e7aises"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.pharma.2022.10.002","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T12:47:01Z","timestamp":1665751621000},"page":"446-456","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["The effect of hydro alcoholic extract of Nigella sativa seeds on inflammatory mediators in C6 glioma cell line"],"prefix":"10.1016","volume":"81","author":[{"given":"M.","family":"Esmaeili Tarzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Kordestani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mehrabani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Yahyapour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Raeiszadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Bahrampour Juybari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Sharififar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.pharma.2022.10.002_bib0320","first-page":"102","article-title":"Caprylic (Octanoic) Acid as a potential fatty acid chemotherapeutic for glioblastoma","volume":"159","author":"Altinoz","year":"2020","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"1","key":"10.1016\/j.pharma.2022.10.002_bib0325","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/2014.10.FOCUS12367","article-title":"Survival and low-grade glioma: the emergence of genetic information","volume":"38","author":"Claus","year":"2015","journal-title":"Neurosurg Focus"},{"issue":"2","key":"10.1016\/j.pharma.2022.10.002_bib0330","first-page":"675","article-title":"Dissecting molecular features of gliomas: genetic loci and validated biomarkers","volume":"21","author":"Arcella","year":"2020","journal-title":"Int J Cell Sci"},{"issue":"3","key":"10.1016\/j.pharma.2022.10.002_bib0335","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/bph.12008","article-title":"Interleukins in glioblastoma pathophysiology: implications for therapy","volume":"168","author":"Yeung","year":"2013","journal-title":"Br J Pharmaco"},{"issue":"1","key":"10.1016\/j.pharma.2022.10.002_bib0340","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s11805-007-0026-7","article-title":"Effects of bradykinin on the expression of interleukin-6 in C6 glioma cells","author":"Wang","year":"2007","journal-title":"Chin Clin Oncol"},{"key":"10.1016\/j.pharma.2022.10.002_bib0345","first-page":"1","article-title":"IL-6 secreted by cancer-associated fibroblasts induces tamoxifen resistance in luminal breast cancer","author":"Sun","year":"2014","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.pharma.2022.10.002_bib0350","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.3892\/or.2014.3366","article-title":"Bradykinin stimulates IL-6 production and cell invasion in colorectal cancer cells","volume":"32","author":"Wang","year":"2014","journal-title":"Oncol Rep"},{"issue":"2","key":"10.1016\/j.pharma.2022.10.002_bib0355","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/s13277-014-2717-z","article-title":"The CCL2\/CCR2 axis enhances IL-6-induced epithelial-mesenchymal transition by cooperatively activating STAT3-Twist signaling","volume":"36","author":"Gao","year":"2015","journal-title":"Tumor Biol"},{"issue":"1","key":"10.1016\/j.pharma.2022.10.002_bib0360","first-page":"1","article-title":"Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner","volume":"4","author":"Xu","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.pharma.2022.10.002_bib0365","doi-asserted-by":"crossref","first-page":"458","DOI":"10.3389\/fncel.2018.00458","article-title":"The interleukin-10 family of cytokines and their role in the CNS","volume":"2","author":"Burmeister","year":"2018","journal-title":"Front Cell Neurosci"},{"issue":"2","key":"10.1016\/j.pharma.2022.10.002_bib0370","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ccr.2006.11.023","article-title":"High TGF\u03b2-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene","volume":"11","author":"Bruna","year":"2007","journal-title":"Cancer Cell"},{"issue":"6","key":"10.1016\/j.pharma.2022.10.002_bib0375","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.1074\/jbc.M303654200","article-title":"A failure of transforming growth factor-\u03b21 negative regulation maintains sustained NF-\u03baB activation in gut inflammation","volume":"279","author":"Monteleone","year":"2004","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.pharma.2022.10.002_bib0380","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/neuonc\/nov265","article-title":"Nuclear factor-\u03baB in glioblastoma: insights into regulators and targeted therapy","volume":"18","author":"Cahill","year":"2015","journal-title":"Neuro-oncol"},{"issue":"1","key":"10.1016\/j.pharma.2022.10.002_bib0385","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s40139-012-0006-3","article-title":"Inflammation and gliomagenesis: bi-directional communication at early and late stages of tumor progression","volume":"1","author":"Galvao","year":"2013","journal-title":"Curr Pathobiol Reports"},{"issue":"9","key":"10.1016\/j.pharma.2022.10.002_bib0390","doi-asserted-by":"crossref","first-page":"6413","DOI":"10.1007\/s11033-021-06641-1","article-title":"Naringenin attenuates cell viability and migration of C6 glioblastoma cell line: a possible role of hedgehog signaling pathway","volume":"48","author":"Lotfian\u00a0Sargazi","year":"2021","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.pharma.2022.10.002_bib0395","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/978-3-642-36605-5_13","article-title":"Bioactive substances of plant origin\u00a030","volume":"967","author":"Zhao","year":"2015","journal-title":"Handb Food Chem"},{"issue":"1","key":"10.1016\/j.pharma.2022.10.002_bib0400","first-page":"1","article-title":"Targeting the hallmarks of cancer: the effects of silibinin on proliferation, cell death, angiogenesis, and migration in colorectal cancer","volume":"21","author":"Smeri","year":"2021","journal-title":"BMC Compl Med Ther"},{"issue":"4","key":"10.1016\/j.pharma.2022.10.002_bib0405","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1007\/s43440-019-00023-y","article-title":"Crocin: a protective natural antioxidant against pulmonary fibrosis induced by bleomycin","volume":"72","author":"Mehrabani","year":"2020","journal-title":"Pharmacol Rep"},{"issue":"2","key":"10.1016\/j.pharma.2022.10.002_bib0410","first-page":"150","article-title":"Reduced IKK\/NF-kB expression by Nigella Sativa extract in breast cancer","volume":"11","author":"Kordestani","year":"2020","journal-title":"Middle East J Cancer"},{"issue":"3","key":"10.1016\/j.pharma.2022.10.002_bib0415","first-page":"263","article-title":"Early and late preventive effect of Nigella sativa on the bleomycin-induced pulmonary fibrosis in rats: An experimental study","volume":"8","author":"Poursalehi","year":"2018","journal-title":"Avicenna J Phytomed"},{"key":"10.1016\/j.pharma.2022.10.002_bib0420","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.biopha.2017.04.009","article-title":"Nigella sativa, a traditional Tunisian herbal medicine, attenuates bleomycin-induced pulmonary fibrosis in a rat model","volume":"90","author":"Abidi","year":"2017","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"10.1016\/j.pharma.2022.10.002_bib0425","first-page":"317","article-title":"Bioassay screening of the essential oil and various extracts from 4 spices medicinal plants","volume":"22","author":"Sharififar","year":"2009","journal-title":"Pakistan J Pharm Sci"},{"issue":"1","key":"10.1016\/j.pharma.2022.10.002_bib0430","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s13277-014-2628-z","article-title":"Thymoquinone inhibits proliferation and invasion of human nonsmall-cell lung cancer cells via ERK pathway","volume":"36","author":"Yang","year":"2015","journal-title":"Tumor Biol"},{"issue":"4","key":"10.1016\/j.pharma.2022.10.002_bib0435","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s10620-014-3394-x","article-title":"Thymoquinone pretreatment overcomes the insensitivity and potentiates the antitumor effect of gemcitabine through abrogation of Notch1, PI3K\/Akt\/mTOR regulated signaling pathways in pancreatic cancer","volume":"60","author":"Mu","year":"2015","journal-title":"Digest Dis Sci"},{"issue":"2","key":"10.1016\/j.pharma.2022.10.002_bib0440","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1080\/01635581.2013.755554","article-title":"Use of an abridged scored Patient-Generated Subjective Global Assessment (abPG-SGA) as a nutritional screening tool for cancer patients in an outpatient setting","volume":"65","author":"Gabrielson","year":"2013","journal-title":"Nutr Cancer"},{"issue":"1","key":"10.1016\/j.pharma.2022.10.002_bib0445","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-4598-12-15","article-title":"MiR-29c is downregulated in gastric carcinomas and regulates cell proliferation by targeting RCC2","volume":"12","author":"Matsuo","year":"2013","journal-title":"Mol Cancer"},{"issue":"3","key":"10.1016\/j.pharma.2022.10.002_bib0450","doi-asserted-by":"crossref","first-page":"634","DOI":"10.18632\/oncotarget.1596","article-title":"Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-\u03baB regulated gene products in multiple myeloma xenograft mouse model","volume":"5","author":"Siveen","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.pharma.2022.10.002_bib0455","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.toxrep.2020.12.026","article-title":"Investigation of cellular effects of thymoquinone on glioma cell","volume":"8","author":"Guler","year":"2021","journal-title":"Toxicology Rep"},{"issue":"1","key":"10.1016\/j.pharma.2022.10.002_bib0460","first-page":"195","article-title":"Cytotoxic and antiproliferative effects of thymoquinone on rat C6 glioma cells depend on oxidative stress","volume":"462","author":"Guler","year":"2019","journal-title":"Mol Cell Biochem"},{"issue":"2","key":"10.1016\/j.pharma.2022.10.002_bib0465","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2174\/1874609812666190808153246","article-title":"Nigella sativa L., Supplementary plant with anticholinesterase effect for cognition problems: a kinetic study","volume":"13","author":"Ansari","year":"2020","journal-title":"Curr Aging Sci"},{"issue":"2021","key":"10.1016\/j.pharma.2022.10.002_bib0470","first-page":"101","article-title":"Efficacy of herbal based syrup on male sexual experiences: a double-blind randomized clinical trial","volume":"11","author":"Ebrahimpour","year":"2020","journal-title":"J Tradit Complement Med"},{"key":"10.1016\/j.pharma.2022.10.002_bib0475","first-page":"178","article-title":"Estimation of total flavonoid content in propolis by two complementary colorimetric methods (3)","author":"Chang","year":"2002","journal-title":"J Food Drug Anal"},{"issue":"5","key":"10.1016\/j.pharma.2022.10.002_bib0480","first-page":"414","article-title":"Evaluation of the cytotoxicity, antibacterial, antioxidant, and anti-inflammatory effects of different extracts of Punica granatum var. pleniflora","volume":"27","author":"Mehrabani","year":"2020","journal-title":"J Kerman Univ Medical Sci"},{"issue":"3","key":"10.1016\/j.pharma.2022.10.002_bib0485","first-page":"804","article-title":"Phytoniosome: a novel drug delivery for myrtle extract","volume":"17","author":"Raeiszadeh","year":"2018","journal-title":"Iran J Pharm Res IJPR"},{"key":"10.1016\/j.pharma.2022.10.002_bib0490","doi-asserted-by":"crossref","first-page":"12570","DOI":"10.1016\/j.jep.2020.112570","article-title":"The efficacy of a traditional medicine preparation on second-degree burn wounds in rats","volume":"252","author":"Ebrahimpour","year":"2020","journal-title":"J Ethnopharmacol"},{"issue":"2","key":"10.1016\/j.pharma.2022.10.002_bib0495","first-page":"126","article-title":"Hypoglycemic effect of lipoic acid, carnitine and Nigella sativa in diabetic rat model","volume":"5","author":"Salama","year":"2011","journal-title":"Int J Health Sci"},{"issue":"4","key":"10.1016\/j.pharma.2022.10.002_bib0500","first-page":"307","article-title":"Effect of Nigella sativa seed extract for hypertension in elderly: a double-blind, randomized controlled trial","volume":"49","author":"Rizka","year":"2018","journal-title":"Acta Medica Indonesiana"},{"issue":"2","key":"10.1016\/j.pharma.2022.10.002_bib0505","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3109\/08923970903307552","article-title":"Radioprotective effects of black seed (Nigella sativa) oil against hemopoietic damage and immunosuppression in gamma-irradiated rats","volume":"32","author":"Assayed","year":"2010","journal-title":"Immunopharmacol Immunotoxicol"},{"issue":"1","key":"10.1016\/j.pharma.2022.10.002_bib0510","first-page":"5","article-title":"Evaluation of the possible antioxidant effects of Soybean and Nigella sativa during experimental hepatocarcinogenesis by nitrosamine precursors","volume":"32","author":"El Gendy","year":"2007","journal-title":"Turk J Biochem"},{"issue":"1","key":"10.1016\/j.pharma.2022.10.002_bib0515","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0378-8741(03)00157-0","article-title":"Neuropharmacological activity of Nigella sativa L. extracts","volume":"88","author":"Al-Naggar","year":"2003","journal-title":"J Ethnopharmacol"},{"issue":"5","key":"10.1016\/j.pharma.2022.10.002_bib0520","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1745-4514.2011.00567.x","article-title":"Antioxidant, anti-inflammatory, anticancer and antibacterial activities of extracts from Nigella sativa (black cumin) plant parts","volume":"36","author":"Bourgou","year":"2012","journal-title":"J Food Biochem"},{"issue":"6","key":"10.1016\/j.pharma.2022.10.002_bib0525","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.neuro.2011.08.001","article-title":"Protective effect of Nigella sativa oil against tramadol-induced tolerance and dependence in mice: role of nitric oxide and oxidative stress","volume":"32","author":"Abdel-Zaher","year":"2011","journal-title":"Neurotoxicology"},{"issue":"2","key":"10.1016\/j.pharma.2022.10.002_bib0530","first-page":"511","article-title":"Effect of Nigella sativa and Allium cepa oils on Trichinella spiralis in experimentally infected rats","volume":"35","author":"Abu El Ezz","year":"2005","journal-title":"J Egypt Soc Parasitol"},{"issue":"2","key":"10.1016\/j.pharma.2022.10.002_bib0535","doi-asserted-by":"crossref","DOI":"10.4314\/ajtcam.v8i2.63203","article-title":"Detection of the antibacterial effect of nigella sativa ground seedswith water","volume":"8","author":"Bakathir","year":"2011","journal-title":"Afr J Trad Compl Alt Med"},{"issue":"10","key":"10.1016\/j.pharma.2022.10.002_bib0540","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.phymed.2010.01.002","article-title":"Antiasthmatic effect of Nigella sativa in airways of asthmatic patients","volume":"17","author":"Boskabady","year":"2010","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.pharma.2022.10.002_bib0545","first-page":"143","article-title":"Gastroprotective effects of Nigella Sativa oil on the formation of stress gastritis in hypothyroidal rats","volume":"1","author":"Abdel-Sater","year":"2009","journal-title":"Int J Physiol Pathophysiol Pharmacol"},{"key":"10.1016\/j.pharma.2022.10.002_bib0550","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/00008469-200504000-00012","article-title":"Inhibition of two stage renal carcinogenesis, oxidative damage and hyperproliferative response by Nigella sativa","volume":"14","author":"Khan","year":"2005","journal-title":"Eur J Cancer Prev"},{"issue":"5","key":"10.1016\/j.pharma.2022.10.002_bib0555","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1472-8206.2007.00509.x","article-title":"The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients","volume":"21","author":"Boskabady","year":"2007","journal-title":"Fund Clin Pharmacol"},{"issue":"8","key":"10.1016\/j.pharma.2022.10.002_bib0560","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1002\/ptr.3679","article-title":"Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study","volume":"26","author":"Gheita","year":"2012","journal-title":"Phytother Res"},{"issue":"6","key":"10.1016\/j.pharma.2022.10.002_bib0565","doi-asserted-by":"crossref","first-page":"e39841","DOI":"10.1371\/journal.pone.0039841","article-title":"Nigella sativa (black cumin) seed extract alleviates symptoms of allergic diarrhea in mice, involving opioid receptors","volume":"7","author":"Duncker","year":"2012","journal-title":"PLoS One"},{"issue":"1\u20133","key":"10.1016\/j.pharma.2022.10.002_bib0570","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jep.2005.04.002","article-title":"Anti -dermatophyte activity of ether extract of Nigella sativa and its active principle, thymoquinone","volume":"101","author":"Aljabre","year":"2005","journal-title":"J Ethno Pharmacol"},{"issue":"2","key":"10.1016\/j.pharma.2022.10.002_bib0575","first-page":"25","article-title":"Oral and intraperitoneal LD50 of thymoquinone, an active principle of Nigella sativa, in mice and rats","volume":"20","author":"Al-Ali","year":"2008","journal-title":"J Ayub Med Coll Abbottabad"},{"issue":"3","key":"10.1016\/j.pharma.2022.10.002_bib0580","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s12013-012-9493-4","article-title":"Hormetic\/cytotoxic effects of Nigella sativa seed alcoholic and aqueous extracts on MCF-7 breast cancer cells alone or in combination with doxorubicin","volume":"66","author":"Mahmoud","year":"2013","journal-title":"Cell Biochem Biophys"},{"issue":"5","key":"10.1016\/j.pharma.2022.10.002_bib0585","doi-asserted-by":"crossref","first-page":"913","DOI":"10.3892\/ol_00000162","article-title":"Cancer chemopreventive potential of volatile oil from black cumin seeds, Nigella sativa L., in a rat multi-organ carcinogenesis bioassay","volume":"1","author":"Salim","year":"2010","journal-title":"Oncol Lett"},{"issue":"4","key":"10.1016\/j.pharma.2022.10.002_bib0590","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.coph.2009.04.008","article-title":"Anti-inflammatory and pro-inflammatory roles of TGF-\u03b2, IL-10, and IL-22 in immunity and autoimmunity","volume":"9","author":"Sanjabi","year":"2009","journal-title":"Curr Opin Pharmacol"},{"issue":"1","key":"10.1016\/j.pharma.2022.10.002_bib0595","first-page":"34","article-title":"Effects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial","volume":"6","author":"Hadi","year":"2016","journal-title":"Avicenna J Phytomed"},{"issue":"1","key":"10.1016\/j.pharma.2022.10.002_bib0600","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cbi.2012.03.003","article-title":"Modulation of the oxidative stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritis in Wistar rats","volume":"197","author":"Zargan","year":"2012","journal-title":"Chem-biol Interact"},{"key":"10.1016\/j.pharma.2022.10.002_bib0605","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/978-94-007-4719-7_9","article-title":"TGF beta signaling and its role in glioma pathogenesis","volume":"986","author":"Kaminska","year":"2013","journal-title":"Glioma Signal"},{"issue":"12","key":"10.1016\/j.pharma.2022.10.002_bib0610","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1038\/onc.2012.171","article-title":"TGF-\u03b2 and NF-\u03baB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers","volume":"32","author":"Freudlsperger","year":"2013","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.pharma.2022.10.002_bib0615","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/jnc.13876","article-title":"Neuroglobin protects astroglial cells from hydrogen peroxide-induced oxidative stress and apoptotic cell death","volume":"140","author":"Amri","year":"2017","journal-title":"J Neurochem"},{"issue":"1","key":"10.1016\/j.pharma.2022.10.002_bib0620","first-page":"1","article-title":"Targeting NF-\u03baB pathway for the therapy of diseases: mechanism and clinical study","volume":"5","author":"Yu","year":"2020","journal-title":"Signal Transduct Target Ther"},{"issue":"2","key":"10.1016\/j.pharma.2022.10.002_bib0625","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cellimm.2011.01.002","article-title":"Perinatal supplementation with thymoquinone improves diabetic complications and T cell immune responses in rat offspring","volume":"267","author":"Badr","year":"2011","journal-title":"Cell Immun"},{"issue":"2","key":"10.1016\/j.pharma.2022.10.002_bib0630","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3390\/antiox8020051","article-title":"Antioxidant and anti-inflammatory properties of Nigella sativa oil in human pre-adipocytes","volume":"8","author":"Bordoni","year":"2019","journal-title":"Antioxidants"}],"container-title":["Annales Pharmaceutiques Fran\u00e7aises"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003450922001432?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003450922001432?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:37:34Z","timestamp":1777394254000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003450922001432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":63,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S0003450922001432"],"URL":"https:\/\/doi.org\/10.1016\/j.pharma.2022.10.002","relation":{},"ISSN":["0003-4509"],"issn-type":[{"value":"0003-4509","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of hydro alcoholic extract of Nigella sativa seeds on inflammatory mediators in C6 glioma cell line","name":"articletitle","label":"Article Title"},{"value":"Annales Pharmaceutiques Fran\u00e7aises","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharma.2022.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Acad\u00e9mie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}