{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:55:55Z","timestamp":1793051755624,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annales Pharmaceutiques Fran\u00e7aises"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.pharma.2023.05.004","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T02:02:03Z","timestamp":1683856923000},"page":"843-855","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparative assessment of solubility enhancement of itroconazole by solid dispersion and co-crystallization technique: Investigation of simultaneous effect of media composition on drug dissolution"],"prefix":"10.1016","volume":"81","author":[{"given":"Kusum","family":"Rajbhar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav Ramesh","family":"Karodadeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Barethiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amol","family":"Lahane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubham","family":"Kale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaibhav","family":"Thakre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gouri","family":"Dixit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Kohale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Hiradeve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilesh Ramesh","family":"Rarokar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1\u20132","key":"10.1016\/j.pharma.2023.05.004_bib0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2017.12.041","article-title":"Enhancing the solubility and bioavailability of poorly water-soluble drugs using supercritical antisolvent (SAS) process","volume":"538","author":"Abuzar","year":"2018","journal-title":"Int J Pharm"},{"key":"10.1016\/j.pharma.2023.05.004_bib0235","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jconrel.2017.11.005","article-title":"Recent strategies in spray drying for the enhanced bioavailability of poorly water-soluble drugs","volume":"269","author":"Davis","year":"2018","journal-title":"J Control Release"},{"key":"10.1016\/j.pharma.2023.05.004_bib0240","first-page":"195727","article-title":"Drug solubility: importance and enhancement techniques","volume":"2012","author":"Savjani","year":"2012","journal-title":"ISRN Pharm"},{"key":"10.1016\/j.pharma.2023.05.004_bib0245","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1021\/jm030267j","article-title":"Characteristic physical properties and structural fragments of marketed oral drugs","volume":"47","author":"Vieth","year":"2004","journal-title":"J Med Chem"},{"key":"10.1016\/j.pharma.2023.05.004_bib0250","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0378-5173(99)00191-X","article-title":"Enhanced solubility and dissolution rate of itraconazole by a solid dispersion technique","volume":"187","author":"Jung","year":"1999","journal-title":"Int J Pharm"},{"key":"10.1016\/j.pharma.2023.05.004_bib0255","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ijpharm.2008.09.034","article-title":"Preparation and evaluation of itraconazole dihydrochloride for the solubility and dissolution rate enhancement","volume":"367","author":"Tao","year":"2009","journal-title":"Int J Pharm"},{"key":"10.1016\/j.pharma.2023.05.004_bib0260","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.ijpharm.2012.05.039","article-title":"Enhanced solubility and oral bioavailability of itraconazole by combining membrane emulsification and spray drying technique","volume":"434","author":"Choi","year":"2012","journal-title":"Int J Pharm"},{"issue":"1","key":"10.1016\/j.pharma.2023.05.004_bib0265","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4103\/2230-973X.96921","article-title":"Improvement in solubility of poor water-soluble drugs by solid dispersion","volume":"2","author":"Sareen","year":"2012","journal-title":"Int J Pharm Investig"},{"issue":"1","key":"10.1016\/j.pharma.2023.05.004_bib0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.2042-7158.1975.tb09369.x","article-title":"Improvement of solubility and dissolution rate of poorly water-soluble salicylic acid by a spray dying technique","volume":"27","author":"Kawashima","year":"1975","journal-title":"J Pharm Pharmacol"},{"issue":"8","key":"10.1016\/j.pharma.2023.05.004_bib0275","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1007\/s11095-006-9032-3","article-title":"Use of glutaric acid cocrystal to improve oral bioavailability of a low solubility API","volume":"23","author":"Mcnamara","year":"2006","journal-title":"Pharm Res"},{"issue":"2\u20133","key":"10.1016\/j.pharma.2023.05.004_bib0280","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ejps.2004.10.005","article-title":"Clinical study of solid dispersions of itraconazole prepared by hot-stage extrusion","volume":"24","author":"Six","year":"2005","journal-title":"Eur J Pharm Sci"},{"issue":"7","key":"10.1016\/j.pharma.2023.05.004_bib0285","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1007\/BF02977355","article-title":"Preparation and characterization of solid dispersions of itraconazole by using aerosol solvent extraction system for improvement in drug solubility and bioavailability","volume":"28","author":"Lee","year":"2005","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.pharma.2023.05.004_bib0290","first-page":"2801","article-title":"Itraconazole solid dispersion prepared by a supercritical fluid technique: preparation, in vitro characterization, and bioavailability in beagle dogs","volume":"9","author":"Yin","year":"2015","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.pharma.2023.05.004_bib0295","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1007\/s11095-016-1890-8","article-title":"Characterization of solid dispersion of itraconazole prepared by solubilization in concentrated aqueous solutions of weak organic acids and drying","volume":"33","author":"Parikh","year":"2016","journal-title":"Pharm Res"},{"issue":"12","key":"10.1016\/j.pharma.2023.05.004_bib0300","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1111\/jphp.12805","article-title":"Characterization and pharmacokinetic study of itraconazole solid dispersions prepared by solvent-controlled precipitation and spray-dry methods","volume":"69","author":"Sim","year":"2017","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.pharma.2023.05.004_bib0305","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.3390\/pharmaceutics14112398","article-title":"Itraconazole amorphous solid dispersion tablets: formulation and compaction process optimization using quality by design principles and tools","volume":"14","author":"Triboandas","year":"2022","journal-title":"Pharmaceutics"},{"issue":"7","key":"10.1016\/j.pharma.2023.05.004_bib0310","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1021\/bm070226v","article-title":"Solubilization of docetaxel in poly (ethylene oxide)-block-poly (butylene\/styrene oxide) micelles","volume":"8","author":"Elsabahy","year":"2007","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.pharma.2023.05.004_bib0315","doi-asserted-by":"crossref","first-page":"103251","DOI":"10.1016\/j.jddst.2022.103251","article-title":"Phospholipid based colloidal nanocarriers for enhanced solubility and therapeutic efficacy of withanolides","volume":"70","author":"Saoji","year":"2022","journal-title":"J Drug Deliv Sci Technol"},{"issue":"2","key":"10.1016\/j.pharma.2023.05.004_bib0320","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/jps.20535","article-title":"Phase solubility and inclusion complex of itraconazole with \u03b2-cyclodextrin using supercritical carbon dioxide","volume":"95","author":"Al-Marzouqi","year":"2006","journal-title":"J Pharm Sci"},{"issue":"7","key":"10.1016\/j.pharma.2023.05.004_bib0325","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.3390\/pharmaceutics14071393","article-title":"Preparation of terbinafin-encapsulated solid lipid nanoparticles containing antifungal Carbopol\u00ae hydrogel with improved efficacy: in vitro, ex vivo and in vivo study","volume":"14","author":"Rarokar","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.pharma.2023.05.004_bib0330","doi-asserted-by":"crossref","first-page":"103444","DOI":"10.1016\/j.jddst.2022.103444","article-title":"Biogenic synthesis of zinc oxide nanoparticles using mushroom fungus Cordyceps militaris: characterization and mechanistic insights of therapeutic investigation","volume":"73","author":"Dias","year":"2022","journal-title":"J Drug Deliv Sci Technol"},{"key":"10.1016\/j.pharma.2023.05.004_bib0335","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.msec.2018.04.074","article-title":"Solid dispersion of dutasteride using the solvent evaporation method: approaches to improve dissolution rate and oral bioavailability in rats","volume":"90","author":"Choi","year":"2018","journal-title":"Mater Sci Eng C"},{"key":"10.1016\/j.pharma.2023.05.004_bib0340","doi-asserted-by":"crossref","first-page":"E87","DOI":"10.1208\/pt070368","article-title":"Enhancement of dissolution profile by solid dispersion (kneading) technique","volume":"7","author":"Modi","year":"2006","journal-title":"AAPS PharmSciTech"},{"issue":"2","key":"10.1016\/j.pharma.2023.05.004_bib0345","doi-asserted-by":"crossref","first-page":"161","DOI":"10.22146\/ijc.24884","article-title":"Formation of ketoprofen-malonic acid cocrystal by solvent evaporation method","volume":"17","author":"Wicaksono","year":"2017","journal-title":"Indones J Chem"},{"issue":"8","key":"10.1016\/j.pharma.2023.05.004_bib0350","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1039\/C9CE01886G","article-title":"Microwave assisted slurry conversion crystallization for manufacturing of new co-crystals of sulfamethazine and sulfamerazine","volume":"22","author":"Ahuja","year":"2020","journal-title":"CrystEngComm"},{"issue":"6","key":"10.1016\/j.pharma.2023.05.004_bib0355","doi-asserted-by":"crossref","first-page":"997","DOI":"10.4314\/tjpr.v17i6.3","article-title":"Co-crystalization of quercetin and malonic acid using solvent-drop grinding method","volume":"17","author":"Setyawan","year":"2018","journal-title":"Trop J Pharm Res"},{"issue":"1\u20132","key":"10.1016\/j.pharma.2023.05.004_bib0360","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ijpharm.2011.05.052","article-title":"Preparation and characterization of pH-independent sustained release tablet containing solid dispersion granules of a poorly water-soluble drug","volume":"415","author":"Tran","year":"2011","journal-title":"Int J Pharm"},{"issue":"6","key":"10.1016\/j.pharma.2023.05.004_bib0365","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.jsps.2022.04.002","article-title":"Solubility enhancement of some poorly soluble drugs by solid dispersion using Ziziphus spina-christi gum polymer","volume":"30","author":"Alwossabi","year":"2022","journal-title":"Saudi Pharm J"},{"issue":"2","key":"10.1016\/j.pharma.2023.05.004_bib0370","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.ijpharm.2015.11.007","article-title":"Molecular interaction between glimepiride and Soluplus\u00ae-PEG 4000 hybrid based solid dispersions: characterisation and anti-diabetic studies","volume":"496","author":"Reginald-Opara","year":"2015","journal-title":"Int J Pharm"},{"issue":"2","key":"10.1016\/j.pharma.2023.05.004_bib0375","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ejps.2005.06.005","article-title":"Preparation and evaluation of glibenclamide-polyglycolized glycerides solid dispersions with silicon dioxide by spray drying technique","volume":"26","author":"Chauhan","year":"2005","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.pharma.2023.05.004_bib0380","doi-asserted-by":"crossref","unstructured":"Rarokar N.R., Telange D.R., Khedekar P.B., Kalsait R.P. Solubility enhancement of extract of Lagenaria siceraria by development of Phospholipon\u00ae 90 H modulated phospholipid complex employing Box-Behnken design. Ann Pharm Fr [Published Online-Article in Press] doi:10.1016\/j.pharma.2022.11.007.","DOI":"10.1016\/j.pharma.2022.11.007"},{"issue":"8","key":"10.1016\/j.pharma.2023.05.004_bib0385","first-page":"1","article-title":"Meloxicam encapsulated nanostructured colloidal self-assembly for evaluating antitumor and anti-inflammatory efficacy in 3D printed scaffolds","volume":"109","author":"Rarokar","year":"2020","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.pharma.2023.05.004_bib0390","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1208\/s12249-015-0369-y","article-title":"Nanostructured cubosomes in a thermoresponsive depot system: an alternative approach for the controlled delivery of docetaxel","volume":"17","author":"Rarokar","year":"2016","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.pharma.2023.05.004_bib0395","doi-asserted-by":"crossref","first-page":"120842","DOI":"10.1016\/j.molliq.2022.120842","article-title":"Pteroyl-c-l-glutamate\/Pluronic\u00ae F68 modified polymeric micelles loaded with docetaxel for targeted delivery and reduced toxicity","volume":"369","author":"Rarokar","year":"2023","journal-title":"J Mol Liq"},{"issue":"8","key":"10.1016\/j.pharma.2023.05.004_bib0400","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.3109\/03639045.2015.1118495","article-title":"Sucralose as co-crystal co-former for hydrochlorothiazide: development of oral disintegrating tablets","volume":"42","author":"Arafa","year":"2016","journal-title":"Drug Dev Ind Pharm"},{"issue":"3","key":"10.1016\/j.pharma.2023.05.004_bib0405","doi-asserted-by":"crossref","first-page":"399","DOI":"10.15171\/apb.2017.048","article-title":"Pharmaceutical cocrystal of piroxicam: design, formulation and evaluation","volume":"7","author":"Panzade","year":"2017","journal-title":"Adv Pharm Bull"},{"key":"10.1016\/j.pharma.2023.05.004_bib0410","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2147\/DHPS.S282420","article-title":"In-vitro evaluations of quality control parameters of paracetamol tablets marketed in Gondar city, Northwest Ethiopia","volume":"12","author":"Abebe","year":"2020","journal-title":"Drug Healthc Patient Saf"},{"issue":"7","key":"10.1016\/j.pharma.2023.05.004_bib0415","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1016\/j.xphs.2018.03.020","article-title":"Powder compression properties of paracetamol, paracetamol hydrochloride, and paracetamol cocrystals and coformers","volume":"107","author":"Persson","year":"2018","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.pharma.2023.05.004_bib0420","doi-asserted-by":"crossref","first-page":"6642826","DOI":"10.1155\/2021\/6642826","article-title":"Consumers\u2019 perception of generic medicines and evaluation of in vitro quality control parameters of locally manufactured paracetamol tablets in Asmara, Eritrea: a cross-sectional study","volume":"2021","author":"Idris","year":"2021","journal-title":"Biomed Res Int"},{"issue":"2\u20133","key":"10.1016\/j.pharma.2023.05.004_bib0425","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.jconrel.2005.08.024","article-title":"Development of novel sustained-release system, disintegration-controlled matrix tablet (DCMT) with solid dispersion granules of nilvadipine","volume":"108","author":"Tanaka","year":"2005","journal-title":"J Control Release"},{"issue":"2","key":"10.1016\/j.pharma.2023.05.004_bib0430","doi-asserted-by":"crossref","first-page":"222","DOI":"10.4103\/0250-474X.25719","article-title":"Fast dissolving valdecoxib tablets containing solid dispersion of valdecoxib","volume":"68","author":"Patel","year":"2006","journal-title":"Indian J Pharm Sci"},{"key":"10.1016\/j.pharma.2023.05.004_bib0435","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.ijbiomac.2018.12.130","article-title":"Development of self-assembled nanocarriers to enhance the antitumor efficacy of docetaxel trihydrate in the MDA-MB-231 cell line","volume":"125","author":"Rarokar","year":"2019","journal-title":"Int J Biol Macromol"},{"issue":"6","key":"10.1016\/j.pharma.2023.05.004_bib0440","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1208\/s12249-015-0332-y","article-title":"Formulation development of spherical crystal agglomerates of itraconazole for preparation of directly compressible tablets with enhanced bioavailability","volume":"16","author":"Fadke","year":"2015","journal-title":"AAPS PharmSciTech"},{"issue":"9","key":"10.1016\/j.pharma.2023.05.004_bib0445","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.3390\/ijms20092167","article-title":"Membrane lipid composition: effect on membrane and organelle structure, function and compartmentalization and therapeutic avenues","volume":"20","author":"Casares","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.pharma.2023.05.004_bib0450","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bjae.2019.10.002","article-title":"Basic pharmacology of local anaesthetics","volume":"20","author":"Taylor","year":"2020","journal-title":"BJA Educ"}],"container-title":["Annales Pharmaceutiques Fran\u00e7aises"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003450923000500?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003450923000500?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T12:26:25Z","timestamp":1762086385000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003450923000500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S0003450923000500"],"URL":"https:\/\/doi.org\/10.1016\/j.pharma.2023.05.004","relation":{},"ISSN":["0003-4509"],"issn-type":[{"value":"0003-4509","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative assessment of solubility enhancement of itroconazole by solid dispersion and co-crystallization technique: Investigation of simultaneous effect of media composition on drug dissolution","name":"articletitle","label":"Article Title"},{"value":"Annales Pharmaceutiques Fran\u00e7aises","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharma.2023.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Acad\u00e9mie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}