{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T21:57:42Z","timestamp":1781301462166,"version":"3.54.1"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annales Pharmaceutiques Fran\u00e7aises"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.pharma.2026.05.007","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T05:38:10Z","timestamp":1779428290000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development, validation and application of LC\u2013MS\/MS method for simultaneous determination of irinotecan and cyclosporine in co-loaded self-nanoemulsifying drug delivery system"],"prefix":"10.1016","author":[{"given":"Rati","family":"Yadav","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padakanti Sandeep","family":"Chary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshada Anil","family":"Bhalerao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Sonti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5275-8065","authenticated-orcid":false,"given":"Neelesh Kumar","family":"Mehra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharma.2026.05.007_bib0135","doi-asserted-by":"crossref","first-page":"iii1","DOI":"10.1093\/annonc\/mdu260","article-title":"Metastatic colorectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"25","author":"Van Cutsem","year":"2014","journal-title":"Ann Oncol"},{"key":"10.1016\/j.pharma.2026.05.007_bib0140","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1093\/annonc\/mdf337","article-title":"Irinotecan: mechanisms of tumor resistance and novel strategies for modulating its activity","volume":"13","author":"Xu","year":"2002","journal-title":"Ann Oncol"},{"key":"10.1016\/j.pharma.2026.05.007_bib0145","doi-asserted-by":"crossref","first-page":"2624960","DOI":"10.3389\/fonc.2020.624954","article-title":"Establishment and characterization of an irinotecan-resistant human colon cancer cell line","volume":"10","author":"Wu","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.pharma.2026.05.007_bib0150","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1177\/38.9.1974900","article-title":"Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues","volume":"38","author":"Cordon-Cardo","year":"1990","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.pharma.2026.05.007_bib0155","first-page":"954","article-title":"Cellular irinotecan resistance in colorectal cancer and overcoming irinotecan refractoriness through various combination trials including DNA methyltransferase inhibitors: a review","volume":"4","author":"Ozawa","year":"2021","journal-title":"Cancer Drug Resist"},{"key":"10.1016\/j.pharma.2026.05.007_bib0160","doi-asserted-by":"crossref","first-page":"5883","DOI":"10.1021\/acsabm.5c00567","article-title":"Nanotechnology-driven colorectal cancer treatment: coencapsulation of irinotecan and cyclosporine A in SNEDDS for superior outcomes","volume":"8","author":"Yadav","year":"2025","journal-title":"Appl Bio Mater"},{"key":"10.1016\/j.pharma.2026.05.007_bib0165","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1517\/13543776.2011.561784","article-title":"The emerging role of P-glycoprotein inhibitors in drug delivery: A patent review","volume":"21","author":"Akhtar","year":"2011","journal-title":"Expert Opin Ther Pat"},{"key":"10.1016\/j.pharma.2026.05.007_bib0170","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jconrel.2012.04.034","article-title":"Delivery of P-glycoprotein substrates using chemosensitizers and nanotechnology for selective and efficient therapeutic outcomes","volume":"161","author":"Nieto Montesinos","year":"2012","journal-title":"J Controlled Release"},{"key":"10.1016\/j.pharma.2026.05.007_bib0175","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.ejpb.2014.06.012","article-title":"Cyclosporin A affects the bioavailability of ginkgolic acids via inhibition of P-gp and BCRP","volume":"88","author":"Li","year":"2014","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.pharma.2026.05.007_bib0180","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ijpharm.2009.08.035","article-title":"Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of Zedoary essential oil: Formulation and bioavailability studies","volume":"383","author":"Zhao","year":"2010","journal-title":"Int J Pharm"},{"key":"10.1016\/j.pharma.2026.05.007_bib0185","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.jchromb.2008.10.011","article-title":"A liquid chromatography\/electrospray ionization mass spectrometry (LC\u2013MS\/MS) assay for the determination of irinotecan (CPT-11) and its two major metabolites in human liver microsomal incubations and human plasma samples","volume":"875","author":"D\u2019Esposito","year":"2008","journal-title":"J Chromatogr B"},{"key":"10.1016\/j.pharma.2026.05.007_bib0190","doi-asserted-by":"crossref","first-page":"e9932","DOI":"10.1002\/rcm.9932","article-title":"Development and validation of a rapid HPLC-MS\/MS method for simultaneous determination of cyclosporine A and tacrolimus in whole blood for routine therapeutic drug monitoring in organ transplantation","volume":"39","author":"Han","year":"2025","journal-title":"Rapid Commun Mass Spectrometr"},{"key":"10.1016\/j.pharma.2026.05.007_bib0195","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/9781118971147.ch20","article-title":"Q8(R2): Pharmaceutical Development","author":"Holm","year":"2017","journal-title":"Quality Guidelines: An Implementation Guide"},{"key":"10.1016\/j.pharma.2026.05.007_bib0200","unstructured":"Sofer GK, Nystrom LEE. Process chromatography: a guide to validation. Google Books n.d. https:\/\/books.google.co.in\/books?hl=en&lr=&id=_MH-BAAAQBAJ&oi=fnd&pg=PP1&dq=FDA+GR.+Validation+of+chromatographic+methods.+center+for+drug+evaluation+and+research+(CDER).+Food+and+Drug+Administration.+1994%3B2.&ots=JgFsMlpsKb&sig=4KJiOchTRDDB4wuFDIcawK2EG5k&redir_esc=y#v=onepage&q&f=false (accessed July 2, 2025)."},{"key":"10.1016\/j.pharma.2026.05.007_bib0205","unstructured":"(R1) IG-Q, 2005 undefined. Validation of analytical procedures: text and methodology. SomatekComICHHT GuidelineQ2 (R1), 2005\u2022somatekCom 2014."},{"key":"10.1016\/j.pharma.2026.05.007_bib0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10837450.2023.2289133","article-title":"Experimental design approach for development of carboplatin loaded chitosan modified liposomal formulation with improved topical vaginal therapeutic potential","volume":"29","author":"Yadav","year":"2024","journal-title":"Pharm Dev Technol"},{"key":"10.1016\/j.pharma.2026.05.007_bib0215","doi-asserted-by":"crossref","first-page":"105493","DOI":"10.1016\/j.jddst.2024.105493","article-title":"QbD-driven thymoquinone laden nanoemulsion for glaucoma management: In vitro, ex vivo, and pre-clinical evaluation","volume":"94","author":"Srivastava","year":"2024","journal-title":"J Drug Deliv Sci Technol"},{"key":"10.1016\/j.pharma.2026.05.007_bib0220","doi-asserted-by":"crossref","first-page":"128821","DOI":"10.1016\/j.ijbiomac.2023.128821","article-title":"Design, development, and evaluation of CDK-4\/6 inhibitor loaded 4-carboxy phenyl boronic acid conjugated pH-sensitive chitosan lecithin nanoparticles in the management of breast cancer","volume":"258","author":"Pooja","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.pharma.2026.05.007_bib0225","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1007\/s13346-023-01342-7","article-title":"Self-nanoemulsifying drug delivery system (SNEDDS) of docetaxel and carvacrol synergizes the anticancer activity and enables safer toxicity profile: optimization, and in-vitro, ex-vivo and in-vivo pharmacokinetic evaluation","volume":"13","author":"Ateeq","year":"2023","journal-title":"Drug Deliv Transl Res"},{"key":"10.1016\/j.pharma.2026.05.007_bib0230","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.colsurfb.2013.06.001","article-title":"Nano scale self-emulsifying oil based carrier system for improved oral bioavailability of camptothecin derivative by P-Glycoprotein modulation","volume":"111","author":"Negi","year":"2013","journal-title":"Colloids Surf B Biointerfaces"},{"key":"10.1016\/j.pharma.2026.05.007_bib0235","doi-asserted-by":"crossref","first-page":"124375","DOI":"10.1016\/j.ijpharm.2024.124375","article-title":"Enhanced oral bioavailability and in vitro evaluation of cannabidiol camel milk-derived exosome formulation in resistant MDA-MB-231 and MDA-MB-468 breast cancer cells","volume":"663","author":"Aare","year":"2024","journal-title":"Int J Pharm"},{"key":"10.1016\/j.pharma.2026.05.007_bib0240","unstructured":"International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use Ich Harmonised guideline bioanalytical method validation and study sample analysis M10 n.d."},{"key":"10.1016\/j.pharma.2026.05.007_bib0245","unstructured":"Quantification of immunosuppressants in blood using LC-MS\/MS - Google Scholar n.d. https:\/\/scholar.google.com\/scholar?hl=en&as_sdt=0%2C5&q=Quantification+of+immunosuppressants+in+blood+using+LC-MS%2FMS&btnG= (accessed June 30, 2025)."},{"key":"10.1016\/j.pharma.2026.05.007_bib0250","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.talanta.2013.04.027","article-title":"Fast LC-MS\/MS analysis of tacrolimus, sirolimus, everolimus and cyclosporin A in dried blood spots and the influence of the hematocrit and immunosuppressant concentration on recovery","volume":"115","author":"Koster","year":"2013","journal-title":"Talanta"},{"key":"10.1016\/j.pharma.2026.05.007_bib0255","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0021-9673(02)01536-4","volume":"987","author":"Shabir","year":"2003","journal-title":"J Chromatogr A"},{"key":"10.1016\/j.pharma.2026.05.007_bib0260","first-page":"1","article-title":"Evaluating the potential of travoprost-thymoquinone co-loaded liposomes: a glaucomatous rabbit model study","author":"Srivastava","year":"2025","journal-title":"Ther Deliv"}],"container-title":["Annales Pharmaceutiques Fran\u00e7aises"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003450926000751?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003450926000751?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T21:39:10Z","timestamp":1781300350000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003450926000751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":26,"alternative-id":["S0003450926000751"],"URL":"https:\/\/doi.org\/10.1016\/j.pharma.2026.05.007","relation":{},"ISSN":["0003-4509"],"issn-type":[{"value":"0003-4509","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development, validation and application of LC\u2013MS\/MS method for simultaneous determination of irinotecan and cyclosporine in co-loaded self-nanoemulsifying drug delivery system","name":"articletitle","label":"Article Title"},{"value":"Annales Pharmaceutiques Fran\u00e7aises","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharma.2026.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Acad\u00e9mie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}