{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:19:59Z","timestamp":1790140799489,"version":"4.0.1"},"reference-count":326,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/Z504658\/1"],"award-info":[{"award-number":["MR\/Z504658\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/Y008944\/1"],"award-info":[{"award-number":["MR\/Y008944\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["SP\/F\/23\/150058"],"award-info":[{"award-number":["SP\/F\/23\/150058"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["CH\/11\/2\/28733"],"award-info":[{"award-number":["CH\/11\/2\/28733"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["RG\/F\/25\/110149"],"award-info":[{"award-number":["RG\/F\/25\/110149"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G1001147\/1"],"award-info":[{"award-number":["G1001147\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005617","name":"BHF Centre of Research Excellence, Oxford","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005617","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006662","name":"National Institute on Handicapped Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006662","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["CH\/11\/2\/28733"],"award-info":[{"award-number":["CH\/11\/2\/28733"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/F\/25\/110149"],"award-info":[{"award-number":["RG\/F\/25\/110149"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["SP\/F\/23\/150058"],"award-info":[{"award-number":["SP\/F\/23\/150058"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["G1001147\/1"],"award-info":[{"award-number":["G1001147\/1"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/F\/22\/110093"],"award-info":[{"award-number":["RG\/F\/22\/110093"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RE\/24\/130012"],"award-info":[{"award-number":["RE\/24\/130012"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["CH\/09\/002\/26360"],"award-info":[{"award-number":["CH\/09\/002\/26360"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["SI\/F\/24\/21170016"],"award-info":[{"award-number":["SI\/F\/24\/21170016"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pharmrev.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Reviews"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.pharmr.2026.100139","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:46:38Z","timestamp":1778579198000},"page":"100139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Vein graft failure: Pathophysiology, detection, prevention and emerging therapeutic strategies"],"prefix":"10.1016","volume":"78","author":[{"given":"Simon D.","family":"Brown","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4406-1158","authenticated-orcid":false,"given":"Sandra","family":"Sanchez-Esteban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4765-0409","authenticated-orcid":false,"given":"Laura","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Miteva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Krilis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3311-9599","authenticated-orcid":false,"given":"Rachael O.","family":"Forsythe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9691-6210","authenticated-orcid":false,"given":"Stuart A.","family":"Nicklin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6259-4222","authenticated-orcid":false,"given":"Samantha","family":"Carmichael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4547-8636","authenticated-orcid":false,"given":"Colin","family":"Berry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawwar","family":"Al-Attar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7971-4628","authenticated-orcid":false,"given":"David E.","family":"Newby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1441-5576","authenticated-orcid":false,"given":"Andrew H.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"22","key":"10.1016\/j.pharmr.2026.100139_bib1","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/j.jacc.2025.08.015","article-title":"Global, regional, and national burden of cardiovascular diseases and risk factors in 204 countries and territories, 1990\u20132023","volume":"86","author":"Stark","year":"2025","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"10.1016\/j.pharmr.2026.100139_bib2","doi-asserted-by":"crossref","first-page":"e1020","DOI":"10.1016\/S2214-109X(19)30255-4","article-title":"Global, regional, and national prevalence and risk factors for peripheral artery disease in 2015: an updated systematic review and analysis","volume":"7","author":"Song","year":"2019","journal-title":"Lancet Glob Health"},{"issue":"4","key":"10.1016\/j.pharmr.2026.100139_bib3","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.jvs.2022.12.015","article-title":"The global burden of peripheral artery disease","volume":"77","author":"Eid","year":"2023","journal-title":"J Vasc Surg"},{"issue":"10390","key":"10.1016\/j.pharmr.2026.100139_bib4","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1016\/S0140-6736(23)00462-2","volume":"401","author":"Bradbury","year":"2023","journal-title":"Lancet"},{"issue":"9501","key":"10.1016\/j.pharmr.2026.100139_bib5","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/S0140-6736(05)67704-5","article-title":"Bypass versus angioplasty in severe ischaemia of the leg (BASIL): multicentre, randomised controlled trial","volume":"366","author":"Adam","year":"2005","journal-title":"Lancet"},{"issue":"25","key":"10.1016\/j.pharmr.2026.100139_bib6","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1056\/NEJMoa2207899","article-title":"Surgery or endovascular therapy for chronic limb-threatening ischemia","volume":"387","author":"Farber","year":"2022","journal-title":"N Engl J Med"},{"issue":"8","key":"10.1016\/j.pharmr.2026.100139_bib7","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1161\/CIR.0000000000001303","article-title":"2025 Heart disease and stroke statistics: a report of US and global data from the American Heart Association","volume":"151","author":"Martin","year":"2025","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib8","doi-asserted-by":"crossref","first-page":"4310","DOI":"10.1093\/ejcts\/ezad286","article-title":"2022 Joint ESC\/EACTS review of the 2018 guideline recommendations on the revascularization of left main coronary artery disease in patients at low surgical risk and anatomy suitable for PCI or CABG","volume":"64","author":"Byrne","year":"2023","journal-title":"Eur J Cardio-Thorac Surg"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib9","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/eurheartj\/ehy394","article-title":"2018 ESC\/EACTS Guidelines on myocardial revascularization","volume":"40","author":"Neumann","year":"2019","journal-title":"Eur Heart J"},{"issue":"3","key":"10.1016\/j.pharmr.2026.100139_bib10","first-page":"e18","article-title":"2021 ACC\/AHA\/SCAI guideline for coronary artery revascularization: a report of the American College of Cardiology\/American Heart Association joint committee on clinical practice guidelines","volume":"145","author":"Lawton","year":"2022","journal-title":"Circulation"},{"issue":"18","key":"10.1016\/j.pharmr.2026.100139_bib11","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1161\/CIRCULATIONAHA.117.027597","article-title":"Mechanisms, consequences, and prevention of coronary graft failure","volume":"136","author":"Gaudino","year":"2017","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib12","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1471-2261-9-53","article-title":"Evaluation of early coronary graft patency after coronary artery bypass graft surgery using multislice computed tomography angiography","volume":"9","author":"Bassri","year":"2009","journal-title":"BMC Cardiovasc Disord"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib13","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13019-023-02199-0","article-title":"Early asymptomatic graft failure in coronary artery bypass grafting: a study based on computed tomography angiography analysis","volume":"18","author":"Han","year":"2023","journal-title":"J Cardiothorac Surg"},{"issue":"8","key":"10.1016\/j.pharmr.2026.100139_bib14","doi-asserted-by":"crossref","first-page":"e972","DOI":"10.4244\/EIJV12I8A160","article-title":"Graft failure prior to discharge after coronary artery bypass surgery: a prospective single-centre study using dual 64-slice computed tomography","volume":"12","author":"Arampatzis","year":"2016","journal-title":"EuroIntervention"},{"issue":"6","key":"10.1016\/j.pharmr.2026.100139_bib15","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1161\/CIRCULATIONAHA.111.040311","article-title":"Relationship between vein graft failure and subsequent clinical outcomes after coronary artery bypass surgery","volume":"125","author":"Lopes","year":"2012","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.pharmr.2026.100139_bib16","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.jacc.2011.12.007","article-title":"Current perspectives on coronary chronic total occlusions","volume":"59","author":"Fefer","year":"2012","journal-title":"J Am Coll Cardiol"},{"issue":"7","key":"10.1016\/j.pharmr.2026.100139_bib17","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.jcin.2014.01.164","article-title":"Native coronary artery patency after coronary artery bypass surgery","volume":"7","author":"Pereg","year":"2014","journal-title":"JACC Cardiovasc Interv"},{"issue":"6","key":"10.1016\/j.pharmr.2026.100139_bib18","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.jcmg.2022.10.002","article-title":"Noninvasive in vivo coronary artery thrombus imaging","volume":"16","author":"Tzolos","year":"2023","journal-title":"J Am Coll Cardiol Imaging"},{"issue":"18","key":"10.1016\/j.pharmr.2026.100139_bib19","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1161\/CIRCULATIONAHA.123.064465","article-title":"Computed tomography cardiac angiography before invasive coronary angiography in patients with previous bypass surgery: the BYPASS-CTCA trial","volume":"148","author":"Jones","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.pharmr.2026.100139_bib20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.xjon.2022.10.006","article-title":"Percutaneous coronary intervention versus repeat surgical revascularization in patients with prior coronary artery bypass grafting: a systematic review and meta-analysis","volume":"12","author":"Dimagli","year":"2022","journal-title":"JTCVS Open"},{"key":"10.1016\/j.pharmr.2026.100139_bib21","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.amjcard.2024.10.021","article-title":"Outcomes after percutaneous coronary intervention in patients with previous coronary artery bypass grafting","volume":"235","author":"Cohen","year":"2025","journal-title":"Am J Cardiol"},{"issue":"22","key":"10.1016\/j.pharmr.2026.100139_bib22","doi-asserted-by":"crossref","first-page":"7118","DOI":"10.3390\/jcm12227118","article-title":"Saphenous vein graft failure: current challenges and a review of the contemporary percutaneous options for management","volume":"12","author":"Back","year":"2023","journal-title":"J Clin Med"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib23","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ejvs.2019.05.006","article-title":"Global vascular guidelines on the management of chronic limb-threatening ischemia","volume":"58","author":"Conte","year":"2019","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.pharmr.2026.100139_bib24","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jss.2023.09.031","article-title":"Failure-to-salvage after femoropopliteal bypass surgery is associated with nonmodifiable risk factors","volume":"293","author":"Kim","year":"2024","journal-title":"J Surg Res"},{"issue":"5","key":"10.1016\/j.pharmr.2026.100139_bib25","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.jvs.2004.08.038","article-title":"Infrainguinal vein bypass graft revision: factors affecting long-term outcome","volume":"40","author":"Nguyen","year":"2004","journal-title":"J Vasc Surg"},{"issue":"5","key":"10.1016\/j.pharmr.2026.100139_bib26","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.ejvs.2019.06.017","volume":"58","author":"Venermo","year":"2019","journal-title":"Eur J Vasc Endovasc Surg"},{"issue":"24","key":"10.1016\/j.pharmr.2026.100139_bib27","doi-asserted-by":"crossref","DOI":"10.1161\/CIR.0000000000001251","article-title":"2024 ACC\/AHA\/AACVPR\/APMA\/ABC\/SCAI\/SVM\/SVN\/SVS\/SIR\/VESS guideline for the management of lower extremity peripheral artery disease: a report of the American College of Cardiology\/American Heart Association joint committee on clinical practice guidelines","volume":"149","author":"Gornik","year":"2024","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib28","first-page":"e57","article-title":"Coronary vein graft disease: pathogenesis and prevention","volume":"25","author":"Parang","year":"2009","journal-title":"Can J Cardiol"},{"issue":"17","key":"10.1016\/j.pharmr.2026.100139_bib29","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1161\/CIRCULATIONAHA.123.064090","article-title":"Graft failure after coronary artery bypass grafting and its association with patient characteristics and clinical events: a pooled individual patient data analysis of clinical trials with imaging follow-up","volume":"148","author":"Gaudino","year":"2023","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.pharmr.2026.100139_bib30","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1161\/CIRCULATIONAHA.105.567495","article-title":"Impact of patient and target-vessel characteristics on arterial and venous bypass graft patency: insight from a randomized trial","volume":"115","author":"Desai","year":"2007","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.pharmr.2026.100139_bib31","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1016\/j.jacc.2004.08.064","article-title":"Long-term patency of saphenous vein and left internal mammary artery grafts after coronary artery bypass surgery","volume":"44","author":"Goldman","year":"2004","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.pharmr.2026.100139_bib32","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/1010-7940(87)90033-9","article-title":"Factors predisposing to wound infection in cardiac surgery A prospective study of 517 patients","volume":"1","author":"Wilson","year":"1987","journal-title":"Eur J Cardio-Thorac Surg"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib33","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S0147-9563(96)80112-9","article-title":"Frequency, manifestations, and correlates of impaired healing of saphenous vein harvest incisions","volume":"25","author":"Wipke-Tevis","year":"1996","journal-title":"Heart Lung"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib34","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0003-4975(98)00392-0","article-title":"Endoscopic versus traditional saphenous vein harvesting: a prospective, randomized trial","volume":"66","author":"Allen","year":"1998","journal-title":"Ann Thorac Surg"},{"issue":"4","key":"10.1016\/j.pharmr.2026.100139_bib35","first-page":"325","article-title":"Risk factors for leg wound complications following endoscopic versus traditional saphenous vein harvesting","volume":"3","author":"Allen","year":"2000","journal-title":"Heart Surg Forum"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib36","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/01.gim.0000196315.32179.82","article-title":"Endoscopic vascular harvest in coronary artery bypass grafting surgery: a consensus statement of the International Society of Minimally Invasive Cardiothoracic Surgery (ISMICS) 2005","volume":"1","author":"Allen","year":"2005","journal-title":"Innovations"},{"issue":"6","key":"10.1016\/j.pharmr.2026.100139_bib37","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1177\/096721099600400617","article-title":"Subcutaneous, video-assisted saphenous vein harvest: report of the first 30 cases","volume":"4","author":"Lumsden","year":"1996","journal-title":"Cardiovasc Surg"},{"issue":"11","key":"10.1016\/j.pharmr.2026.100139_bib38","first-page":"40","article-title":"Endoscopic vessel harvesting in coronary artery bypass graft surgery","volume":"18","author":"Nickum","year":"2005","journal-title":"J Am Acad Physician Assist"},{"issue":"3","key":"10.1016\/j.pharmr.2026.100139_bib39","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jtcvs.2004.08.054","article-title":"Randomized trial of endoscopic versus open vein harvest for coronary artery bypass grafting: six-month patency rates","volume":"129","author":"Yun","year":"2005","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib40","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1067\/mtc.2002.118682","article-title":"A prospective randomized trial of endoscopic versus conventional harvesting of the saphenous vein in coronary artery bypass surgery","volume":"123","author":"Kiaii","year":"2002","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"3","key":"10.1016\/j.pharmr.2026.100139_bib41","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1056\/NEJMoa0900708","article-title":"Endoscopic versus open vein-graft harvesting in coronary-artery bypass surgery","volume":"361","author":"Lopes","year":"2009","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.pharmr.2026.100139_bib42","doi-asserted-by":"crossref","first-page":"586","DOI":"10.21037\/acs.2018.07.05","article-title":"Graft patency after open versus endoscopic saphenous vein harvest in coronary artery bypass grafting surgery: a systematic review and meta-analysis","volume":"7","author":"Kodia","year":"2018","journal-title":"Ann Cardiothorac Surg"},{"issue":"6","key":"10.1016\/j.pharmr.2026.100139_bib43","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1093\/ejcts\/ezt121","article-title":"The influence of endoscopic vein harvesting on outcomes after coronary bypass grafting: a meta-analysis of 267 525 patients","volume":"44","author":"Sastry","year":"2013","journal-title":"Eur J Cardio-Thorac Surg"},{"issue":"5","key":"10.1016\/j.pharmr.2026.100139_bib44","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.jtcvs.2003.10.040","article-title":"Early quantitative coronary angiography of saphenous vein grafts for coronary artery bypass grafting harvested by means of open versus endoscopic saphenectomy: a prospective randomized trial","volume":"127","author":"Perrault","year":"2004","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"5","key":"10.1016\/j.pharmr.2026.100139_bib45","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3109\/14017431.2015.1060354","article-title":"Decreased patency rates following endoscopic vein harvest in coronary artery bypass surgery","volume":"49","author":"Andreasen","year":"2015","journal-title":"Scand Cardiovasc J"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib46","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.jtcvs.2010.10.004","article-title":"Impact of endoscopic versus open saphenous vein harvest technique on late coronary artery bypass grafting patient outcomes in the ROOBY (Randomized On\/Off Bypass) Trial","volume":"141","author":"Zenati","year":"2011","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.pharmr.2026.100139_bib47","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ijsu.2019.11.003","article-title":"Mid-term and long-term outcomes of endoscopic versus open vein harvesting for coronary artery bypass: a systematic review and meta-analysis","volume":"72","author":"Li","year":"2019","journal-title":"Int J Surg"},{"issue":"12","key":"10.1016\/j.pharmr.2026.100139_bib48","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1093\/cvr\/21.12.902","article-title":"Nature and pressure dependence of damage induced by distension of human saphenous vein coronary artery bypass grafts","volume":"21","author":"Angelini","year":"1987","journal-title":"Cardiovasc Res"},{"issue":"11","key":"10.1016\/j.pharmr.2026.100139_bib49","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1093\/cvr\/27.11.1961","article-title":"Surgical preparation induces injury and promotes smooth muscle cell proliferation in a culture of human saphenous vein","volume":"27","author":"Soyombo","year":"1993","journal-title":"Cardiovasc Res"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib50","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3109\/14017439609107239","article-title":"A new no-touch preparation technique: technical notes","volume":"30","author":"Souza","year":"1996","journal-title":"Scand J Thorac Cardiovasc Surg"},{"issue":"4","key":"10.1016\/j.pharmr.2026.100139_bib51","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/S0003-4975(02)03425-2","article-title":"Improved patency in vein grafts harvested with surrounding tissue: results of a randomized study using three harvesting techniques","volume":"73","author":"Souza","year":"2002","journal-title":"Ann Thorac Surg"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib52","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jtcvs.2006.04.002","article-title":"Harvesting the saphenous vein with surrounding tissue for CABG provides long-term graft patency comparable to the left internal thoracic artery: results of a randomized longitudinal trial","volume":"132","author":"Souza","year":"2006","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"4","key":"10.1016\/j.pharmr.2026.100139_bib53","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/ejcts\/ezt560","article-title":"Pedicled no-touch saphenous vein graft harvest limits vascular smooth muscle cell activation: the PATENT saphenous vein graft study","volume":"45","author":"Verma","year":"2014","journal-title":"Eur J Cardio-Thorac Surg"},{"issue":"4","key":"10.1016\/j.pharmr.2026.100139_bib54","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.jtcvs.2015.07.027","article-title":"The no-touch saphenous vein for coronary artery bypass grafting maintains a patency, after 16 years, comparable to the left internal thoracic artery: a randomized trial","volume":"150","author":"Samano","year":"2015","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"4","key":"10.1016\/j.pharmr.2026.100139_bib55","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.jacc.2016.04.058","article-title":"Pedicled vein grafts in coronary surgery exhibit reduced intimal hyperplasia at 6 months","volume":"68","author":"Pettersen","year":"2016","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib56","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13019-019-0887-x","article-title":"SUPERIOR SVG: no touch saphenous harvesting to improve patency following coronary bypass grafting (a multi-centre randomized control trial, NCT01047449)","volume":"14","author":"Deb","year":"2019","journal-title":"J Cardiothorac Surg"},{"issue":"18","key":"10.1016\/j.pharmr.2026.100139_bib57","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1093\/eurheartj\/ehaf018","article-title":"No-touch vein grafts in coronary artery bypass surgery: a registry-based randomized clinical trial","volume":"46","author":"Thelin","year":"2025","journal-title":"Eur Heart J"},{"key":"10.1016\/j.pharmr.2026.100139_bib58","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ahj.2020.03.009","article-title":"No-touch saphenous vein grafts in coronary artery surgery (SWEDEGRAFT): rationale and design of a multicenter, prospective, registry-based randomized clinical trial","volume":"224","author":"Ragnarsson","year":"2020","journal-title":"Am Heart J"},{"issue":"12","key":"10.1016\/j.pharmr.2026.100139_bib59","article-title":"Coronary artery bypass grafting using the no-touch great saphenous vein graft harvesting technique: a retrospective study","volume":"15","author":"Nakajima","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.pharmr.2026.100139_bib60","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2024-082883","article-title":"No-touch versus conventional vein in coronary artery bypass grafting: three year follow-up of multicentre randomised PATENCY trial","volume":"389","author":"Tian","year":"2025","journal-title":"BMJ"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib61","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.surg.2015.03.036","article-title":"Preservation solution impacts physiologic function and cellular viability of human saphenous vein graft","volume":"158","author":"Wise","year":"2015","journal-title":"Surgery"},{"issue":"4","key":"10.1016\/j.pharmr.2026.100139_bib62","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S0003-4975(02)04705-7","article-title":"Multi-photon microscopic evaluation of saphenous vein endothelium and its preservation with a new solution, GALA","volume":"75","author":"Thatte","year":"2003","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib63","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2018-000780","article-title":"DuraGraft vascular conduit preservation solution in patients undergoing coronary artery bypass grafting: rationale and design of a within-patient randomised multicentre trial","volume":"5","author":"Ben Ali","year":"2018","journal-title":"Open Heart"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib64","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0039-6060(97)90184-7","article-title":"Short-term preservation of autogenous vein grafts: effectiveness of University of Wisconsin solution","volume":"121","author":"Cavallari","year":"1997","journal-title":"Surgery"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib65","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/eurheartj\/ehae654","volume":"46","author":"Sandner","year":"2025","journal-title":"Eur Heart J"},{"issue":"5","key":"10.1016\/j.pharmr.2026.100139_bib66","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/jocs.13608","article-title":"The effect of storage solutions, gene therapy, and antiproliferative agents on endothelial function and saphenous vein graft patency","volume":"33","author":"Ben Ali","year":"2018","journal-title":"J Card Surg"},{"issue":"4","key":"10.1016\/j.pharmr.2026.100139_bib67","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3233\/CH-131781","article-title":"Heparinized blood better preserves cellular energy charge and vascular functions of intraoperatively stored saphenous vein grafts in comparison to isotonic sodium-chloride-solution","volume":"55","author":"Wilbring","year":"2013","journal-title":"Clin Hemorheol Microcirc"},{"issue":"8","key":"10.1016\/j.pharmr.2026.100139_bib68","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1001\/jamasurg.2014.87","article-title":"Vein graft preservation solutions, patency, and outcomes after coronary artery bypass graft surgery: follow-up from the PREVENT IV randomized clinical trial","volume":"149","author":"Harskamp","year":"2014","journal-title":"JAMA Surg"},{"issue":"3","key":"10.1016\/j.pharmr.2026.100139_bib69","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1172\/JCI115367","article-title":"Hypoxia induces endothelin gene expression and secretion in cultured human endothelium","volume":"88","author":"Kourembanas","year":"1991","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib70","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jvs.2013.06.004","article-title":"Surgical vein graft preparation promotes cellular dysfunction, oxidative stress, and intimal hyperplasia in human saphenous vein","volume":"60","author":"Osgood","year":"2014","journal-title":"J Vasc Surg"},{"issue":"3","key":"10.1016\/j.pharmr.2026.100139_bib71","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2174\/1570161043385691","article-title":"Reactive oxygen species, vascular disease and cardiovascular surgery","volume":"2","author":"Jeremy","year":"2004","journal-title":"Curr Vasc Pharmacol"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib72","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.coph.2012.01.005","article-title":"Oxidative stress and vein graft failure: a focus on NADH oxidase, nitric oxide and eicosanoids","volume":"12","author":"Weaver","year":"2012","journal-title":"Curr Opin Pharmacol"},{"issue":"3","key":"10.1016\/j.pharmr.2026.100139_bib73","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1055\/s-2007-1000094","article-title":"Time course of post-ischemic superoxide generation venous effluent from reperfused rabbit hindlimbs","volume":"15","author":"Yokoyama","year":"1999","journal-title":"J Reconstr Microsurg"},{"key":"10.1016\/j.pharmr.2026.100139_bib74","series-title":"Mechanisms of Vascular Disease: A Reference Book for Vascular Specialists","author":"Fitridge","year":"2011"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib75","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/bja\/aeh163","article-title":"Physiology of the endothelium","volume":"93","author":"Galley","year":"2004","journal-title":"Br J Anaesth"},{"issue":"3","key":"10.1016\/j.pharmr.2026.100139_bib76","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/S0008-6363(99)00171-6","article-title":"Nitric oxide and the proliferation of vascular smooth muscle cells","volume":"43","author":"Jeremy","year":"1999","journal-title":"Cardiovasc Res"},{"issue":"3","key":"10.1016\/j.pharmr.2026.100139_bib77","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1136\/heart.85.3.342","article-title":"Endothelial function and nitric oxide: clinical relevance","volume":"85","author":"Vallance","year":"2001","journal-title":"Heart"},{"issue":"7","key":"10.1016\/j.pharmr.2026.100139_bib78","doi-asserted-by":"crossref","first-page":"982","DOI":"10.3390\/biom11070982","article-title":"Endothelial dysfunction driven by hypoxia\u2014the influence of oxygen deficiency on NO bioavailability","volume":"11","author":"Janaszak-Jasiecka","year":"2021","journal-title":"Biomolecules"},{"issue":"10","key":"10.1016\/j.pharmr.2026.100139_bib79","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1161\/CIRCULATIONAHA.106.652859","article-title":"Endothelial function and dysfunction: testing and clinical relevance","volume":"115","author":"Deanfield","year":"2007","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.pharmr.2026.100139_bib80","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.7150\/ijbs.7502","article-title":"The vascular endothelium and human diseases","volume":"9","author":"Rajendran","year":"2013","journal-title":"Int J Biol Sci"},{"issue":"5","key":"10.1016\/j.pharmr.2026.100139_bib81","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1097\/SLA.0b013e318288c38d","article-title":"Saphenous vein graft failure after coronary artery bypass surgery: pathophysiology, management, and future directions","volume":"257","author":"Harskamp","year":"2013","journal-title":"Ann Surg"},{"issue":"9","key":"10.1016\/j.pharmr.2026.100139_bib82","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1161\/01.CIR.97.9.916","article-title":"Aortocoronary saphenous vein graft disease: pathogenesis, predisposition, and prevention","volume":"97","author":"Motwani","year":"1998","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.pharmr.2026.100139_bib83","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1182\/blood.V77.3.519.519","article-title":"Role of von Willebrand factor associated to extracellular matrices in platelet adhesion","volume":"77","author":"Baruch","year":"1991","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib84","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1582-4934.2007.00031.x","article-title":"The extracellular matrix and blood vessel formation: not just a scaffold","volume":"11","author":"Rhodes","year":"2007","journal-title":"J Cell Mol Med"},{"issue":"5714","key":"10.1016\/j.pharmr.2026.100139_bib85","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/279636a0","article-title":"Human blood platelet adhesion to artery subendothelium is mediated by factor VIII-von Willebrand factor bound to the subendothelium","volume":"279","author":"Sakariassen","year":"1979","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.pharmr.2026.100139_bib86","first-page":"568","article-title":"Binding of factor VIII-von Willebrand factor to human arterial subendothelium precedes increased platelet adhesion and enhances platelet spreading","volume":"97","author":"Bolhuis","year":"1981","journal-title":"J Lab Clin Med"},{"issue":"6","key":"10.1016\/j.pharmr.2026.100139_bib87","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.thromres.2007.10.005","article-title":"Platelet collagen receptors, signaling and antagonism: emerging approaches for the prevention of intravascular thrombosis","volume":"122","author":"Surin","year":"2008","journal-title":"Thromb Res"},{"issue":"8","key":"10.1016\/j.pharmr.2026.100139_bib88","article-title":"The extracellular matrix signature in vein graft disease","volume":"32","author":"Kahle","year":"2016","journal-title":"Can J Cardiol"},{"issue":"7141","key":"10.1016\/j.pharmr.2026.100139_bib89","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1136\/bmj.316.7141.1328","article-title":"Endothelial cell activation. A central pathophysiological process","volume":"316","author":"Hunt","year":"1998","journal-title":"BMJ"},{"issue":"10","key":"10.1016\/j.pharmr.2026.100139_bib90","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1172\/JCI13005","article-title":"VCAM-1 is critical in atherosclerosis","volume":"107","author":"Ley","year":"2001","journal-title":"J Clin Invest"},{"issue":"13","key":"10.1016\/j.pharmr.2026.100139_bib91","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1093\/cvr\/cvad130","article-title":"Targeting endothelial vascular cell adhesion molecule-1 in atherosclerosis: drug discovery and development of vascular cell adhesion molecule-1-directed novel therapeutics","volume":"119","author":"Pickett","year":"2023","journal-title":"Cardiovasc Res"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib92","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S1734-1140(09)70004-0","article-title":"ICAM-1 signaling in endothelial cells","volume":"61","author":"Lawson","year":"2009","journal-title":"Pharmacol Rep"},{"issue":"12","key":"10.1016\/j.pharmr.2026.100139_bib93","doi-asserted-by":"crossref","first-page":"H1585","DOI":"10.1152\/ajpheart.00096.2013","article-title":"Thrombomodulin and the vascular endothelium: insights into functional, regulatory, and therapeutic aspects","volume":"304","author":"Martin","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib94","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1113\/expphysiol.2007.038588","article-title":"Role of nitric oxide and prostacyclin as vasoactive hormones released by the endothelium","volume":"93","author":"Mitchell","year":"2008","journal-title":"Exp Physiol"},{"issue":"4","key":"10.1016\/j.pharmr.2026.100139_bib95","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2174\/187152506784111463","article-title":"Prostacyclin analogues: prevention of cardiovascular diseases","volume":"4","author":"Nakayama","year":"2006","journal-title":"Cardiovasc Hematol Agents Med Chem"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib96","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/3-540-32967-6_7","article-title":"Nitric oxide and the vascular endothelium","volume":"176","author":"Moncada","year":"2006","journal-title":"Handb Exp Pharmacol"},{"issue":"3","key":"10.1016\/j.pharmr.2026.100139_bib97","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1161\/CIRCRESAHA.107.151860b","article-title":"Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall","volume":"101","author":"Rao","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmr.2026.100139_bib98","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1125126","article-title":"Graft thrombosis after coronary artery bypass surgery and current practice for prevention","volume":"10","author":"Harik","year":"2023","journal-title":"Front Cardiovasc Med"},{"issue":"6","key":"10.1016\/j.pharmr.2026.100139_bib99","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1016\/j.athoracsur.2004.12.054","article-title":"Disruption of graft endothelium correlates with early failure after off-pump coronary artery bypass surgery","volume":"79","author":"Manchio","year":"2005","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.pharmr.2026.100139_bib100","article-title":"Antithrombotic treatment after coronary artery bypass graft surgery: systematic review and network meta-analysis","volume":"367","author":"Solo","year":"2019","journal-title":"BMJ"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib101","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/jocs.12074","article-title":"Dual anti-platelet therapy after coronary artery bypass grafting: is there any benefit? A systematic review and meta-analysis","volume":"28","author":"Deo","year":"2013","journal-title":"J Card Surg"},{"issue":"6","key":"10.1016\/j.pharmr.2026.100139_bib102","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1161\/01.CIR.77.6.1324","article-title":"Improvement in early saphenous vein graft patency after coronary artery bypass surgery with antiplatelet therapy: results of a Veterans Administration Cooperative Study","volume":"77","author":"Goldman","year":"1988","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.pharmr.2026.100139_bib103","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1161\/01.CIR.80.5.1190","article-title":"Saphenous vein graft patency 1 year after coronary artery bypass surgery and effects of antiplatelet therapy. Results of a Veterans Administration cooperative study","volume":"80","author":"Goldman","year":"1989","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.pharmr.2026.100139_bib104","doi-asserted-by":"crossref","DOI":"10.1117\/1.2799521","article-title":"Thinking inside the graft: applications of optical coherence tomography in coronary artery bypass grafting","volume":"12","author":"Brown","year":"2007","journal-title":"J Biomed Opt"},{"issue":"6","key":"10.1016\/j.pharmr.2026.100139_bib105","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.jcin.2011.02.015","article-title":"Evaluation of culprit saphenous vein graft lesions with optical coherence tomography in patients with acute coronary syndromes","volume":"4","author":"Davlouros","year":"2011","journal-title":"JACC Cardiovasc Interv"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib106","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ajpath.2020.10.001","article-title":"Mechanisms of endothelial regeneration and vascular repair and their application to regenerative medicine","volume":"191","author":"Evans","year":"2021","journal-title":"Am J Pathol"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib107","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1161\/CIRCRESAHA.116.306534","article-title":"Protein interactions at endothelial junctions and signaling mechanisms regulating endothelial permeability","volume":"120","author":"Komarova","year":"2017","journal-title":"Circ Res"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib108","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1161\/01.ATV.0000114236.77009.06","article-title":"Characterization of two types of endothelial progenitor cells and their different contributions to neovasculogenesis","volume":"24","author":"Hur","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"4","key":"10.1016\/j.pharmr.2026.100139_bib109","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/7434","article-title":"Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization","volume":"5","author":"Takahashi","year":"1999","journal-title":"Nat Med"},{"issue":"5302","key":"10.1016\/j.pharmr.2026.100139_bib110","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1126\/science.275.5302.964","article-title":"Isolation of putative progenitor endothelial cells for angiogenesis","volume":"275","author":"Asahara","year":"1997","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib111","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1749-6632.2001.tb02075.x","article-title":"Bone marrow as a source of endothelial cells for natural and iatrogenic vascular repair","volume":"953a","author":"Isner","year":"2001","journal-title":"Ann N Y Acad Sci"},{"issue":"11","key":"10.1016\/j.pharmr.2026.100139_bib112","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1161\/01.RES.0000193596.94936.2c","article-title":"Impaired CXCR4 signaling contributes to the reduced neovascularization capacity of endothelial progenitor cells from patients with coronary artery disease","volume":"97","author":"Walter","year":"2005","journal-title":"Circ Res"},{"issue":"25","key":"10.1016\/j.pharmr.2026.100139_bib113","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1161\/01.CIR.0000018166.84319.55","article-title":"Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells","volume":"105","author":"Walter","year":"2002","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib114","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.athoracsur.2006.09.087","article-title":"Endothelial progenitor cells are mobilized after cardiac surgery","volume":"83","author":"Roberts","year":"2007","journal-title":"Ann Thorac Surg"},{"issue":"5","key":"10.1016\/j.pharmr.2026.100139_bib115","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/stcltm\/szac010","article-title":"Endothelial progenitor cells in coronary artery disease: from bench to bedside","volume":"11","author":"Pelliccia","year":"2022","journal-title":"Stem Cells Transl Med"},{"issue":"18","key":"10.1016\/j.pharmr.2026.100139_bib116","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1161\/CIRCULATIONAHA.119.042351","article-title":"Endothelial progenitor cells do not originate from the bone marrow","volume":"140","author":"Fujisawa","year":"2019","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.pharmr.2026.100139_bib117","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1002\/sctm.16-0360","article-title":"Endothelial progenitors: a consensus statement on nomenclature","volume":"6","author":"Medina","year":"2017","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.pharmr.2026.100139_bib118","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.vph.2015.02.018","article-title":"Circulating endothelial progenitor cells: do they live up to their name?","volume":"67\u201369","author":"Madonna","year":"2015","journal-title":"Vasc Pharmacol"},{"issue":"3","key":"10.1016\/j.pharmr.2026.100139_bib119","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1161\/01.CIR.0000046450.89986.50","article-title":"Intramyocardial transplantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial ischemia","volume":"107","author":"Kawamoto","year":"2003","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.pharmr.2026.100139_bib120","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1161\/01.CIR.103.5.634","article-title":"Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia","volume":"103","author":"Kawamoto","year":"2001","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib121","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1749-8090-8-33","article-title":"Application of peripheral-blood-derived endothelial progenitor cell for treating ischemia-reperfusion injury and infarction: a preclinical study in rat models","volume":"8","author":"Chang","year":"2013","journal-title":"J Cardiothorac Surg"},{"issue":"4","key":"10.1016\/j.pharmr.2026.100139_bib122","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1161\/ATVBAHA.111.244970","article-title":"Comparison of various niches for endothelial progenitor cell therapy on ischemic myocardial repair: coexistence of host collateralization and Akt-mediated angiogenesis produces a superior microenvironment","volume":"32","author":"Zhang","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"10.1016\/j.pharmr.2026.100139_bib123","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1161\/hc0602.103673","article-title":"Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration","volume":"105","author":"Iwaguro","year":"2002","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.pharmr.2026.100139_bib124","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/j.biocel.2008.03.012","article-title":"In vivo enhancement of angiogenesis by adenoviral transfer of HIF-1alpha-modified endothelial progenitor cells (Ad-HIF-1alpha-modified EPC for angiogenesis)","volume":"40","author":"Jiang","year":"2008","journal-title":"Int J Biochem Cell Biol"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib125","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1182\/blood-2004-05-1831","article-title":"Increased circulating hematopoietic and endothelial progenitor cells in the early phase of acute myocardial infarction","volume":"105","author":"Massa","year":"2005","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.pharmr.2026.100139_bib126","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1161\/CIRCRESAHA.118.313282","article-title":"Circulating progenitor cells and racial differences","volume":"123","author":"Samman Tahhan","year":"2018","journal-title":"Circ Res"},{"issue":"12","key":"10.1016\/j.pharmr.2026.100139_bib127","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1161\/01.ATV.0000188554.49745.9e","article-title":"Transfer of endothelial progenitor and bone marrow cells influences atherosclerotic plaque size and composition in apolipoprotein E knockout mice","volume":"25","author":"George","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"23","key":"10.1016\/j.pharmr.2026.100139_bib128","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1161\/01.CIR.0000106161.43954.DF","article-title":"Transplantation of bone marrow-derived mononuclear cells in ischemic apolipoprotein E-knockout mice accelerates atherosclerosis without altering plaque composition","volume":"108","author":"Silvestre","year":"2003","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.pharmr.2026.100139_bib129","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1182\/blood.V95.3.952.003k27_952_958","article-title":"Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors","volume":"95","author":"Peichev","year":"2000","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.pharmr.2026.100139_bib130","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.exphem.2007.04.002","article-title":"Human CD34+AC133+VEGFR-2+ cells are not endothelial progenitor cells but distinct, primitive hematopoietic progenitors","volume":"35","author":"Case","year":"2007","journal-title":"Exp Hematol"},{"issue":"227","key":"10.1016\/j.pharmr.2026.100139_bib131","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3006927","article-title":"TGF-\u03b2 signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling","volume":"6","author":"Cooley","year":"2014","journal-title":"Sci Transl Med"},{"issue":"7","key":"10.1016\/j.pharmr.2026.100139_bib132","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/ajh\/hpaf027","article-title":"Endothelial cell phenotypic plasticity in cardiovascular physiology and disease: mechanisms and therapeutic prospects","volume":"38","author":"de Queiroz","year":"2025","journal-title":"Am J Hypertens"},{"issue":"3","key":"10.1016\/j.pharmr.2026.100139_bib133","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/cvr\/cvae021","article-title":"Endothelial to mesenchymal transition: at the axis of cardiovascular health and disease","volume":"120","author":"Hall","year":"2024","journal-title":"Cardiovasc Res"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib134","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jacc.2018.09.089","article-title":"Endothelial to mesenchymal transition in cardiovascular disease: JACC state-of-the-art review","volume":"73","author":"Kovacic","year":"2019","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.pharmr.2026.100139_bib135","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/cvr\/cvv175","article-title":"Endothelial-to-mesenchymal transition contributes to fibro-proliferative vascular disease and is modulated by fluid shear stress","volume":"108","author":"Moonen","year":"2015","journal-title":"Cardiovasc Res"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib136","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1038\/s41598-017-03532-z","article-title":"Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail","volume":"7","author":"Mahmoud","year":"2017","journal-title":"Sci Rep"},{"issue":"8","key":"10.1016\/j.pharmr.2026.100139_bib137","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1161\/ATVBAHA.115.305887","article-title":"High-density lipoproteins reduce endothelial-to-mesenchymal transition","volume":"35","author":"Spillmann","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib138","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11853","article-title":"Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability","volume":"7","author":"Evrard","year":"2016","journal-title":"Nat Commun"},{"issue":"12","key":"10.1016\/j.pharmr.2026.100139_bib139","doi-asserted-by":"crossref","first-page":"4514","DOI":"10.1172\/JCI82719","article-title":"Endothelial-to-mesenchymal transition drives atherosclerosis progression","volume":"125","author":"Chen","year":"2015","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.pharmr.2026.100139_bib140","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1161\/ATVBAHA.113.302071","article-title":"Conserved transcriptional regulatory mechanisms in aortic valve development and disease","volume":"34","author":"Wirrig","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"11","key":"10.1016\/j.pharmr.2026.100139_bib141","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1161\/ATVBAHA.114.302523","article-title":"Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease","volume":"34","author":"Yutzey","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"50","key":"10.1016\/j.pharmr.2026.100139_bib142","doi-asserted-by":"crossref","first-page":"19943","DOI":"10.1073\/pnas.1106954108","article-title":"Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve","volume":"108","author":"Balachandran","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"10.1016\/j.pharmr.2026.100139_bib143","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1161\/CIRCULATIONAHA.108.846782","article-title":"Active adaptation of the tethered mitral valve: insights into a compensatory mechanism for functional mitral regurgitation","volume":"120","author":"Dal-Bianco","year":"2009","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.pharmr.2026.100139_bib144","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jacc.2015.10.092","article-title":"Myocardial infarction alters adaptation of the tethered mitral valve","volume":"67","author":"Dal-Bianco","year":"2016","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"10.1016\/j.pharmr.2026.100139_bib145","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1161\/CIRCULATIONAHA.114.008750","article-title":"Endothelial-to-mesenchymal transition in pulmonary hypertension","volume":"131","author":"Ranchoux","year":"2015","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.pharmr.2026.100139_bib146","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1016\/j.ajpath.2015.03.019","article-title":"Endothelial to mesenchymal transition contributes to endothelial dysfunction in pulmonary arterial hypertension","volume":"185","author":"Good","year":"2015","journal-title":"Am J Pathol"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib147","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1165\/rcmb.2016-0323OC","article-title":"Twist1 in hypoxia-induced pulmonary hypertension through transforming growth factor-\u03b2-Smad signaling","volume":"58","author":"Mammoto","year":"2018","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib148","first-page":"L256","article-title":"Endothelial HIF-2\u03b1 contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition","volume":"314","author":"Tang","year":"2018","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib149","doi-asserted-by":"crossref","first-page":"L118","DOI":"10.1152\/ajplung.00296.2017","article-title":"Isolation and characterization of endothelial-to-mesenchymal transition cells in pulmonary arterial hypertension","volume":"314","author":"Suzuki","year":"2018","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"8","key":"10.1016\/j.pharmr.2026.100139_bib150","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm1613","article-title":"Endothelial-to-mesenchymal transition contributes to cardiac fibrosis","volume":"13","author":"Zeisberg","year":"2007","journal-title":"Nat Med"},{"issue":"24","key":"10.1016\/j.pharmr.2026.100139_bib151","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1016\/j.jacc.2014.02.572","article-title":"Endothelial NADPH oxidase-2 promotes interstitial cardiac fibrosis and diastolic dysfunction through proinflammatory effects and endothelial-mesenchymal transition","volume":"63","author":"Murdoch","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"7","key":"10.1016\/j.pharmr.2026.100139_bib152","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1161\/CIRCRESAHA.115.303794","article-title":"Developmental heterogeneity of cardiac fibroblasts does not predict pathological proliferation and activation","volume":"115","author":"Ali","year":"2014","journal-title":"Circ Res"},{"issue":"7","key":"10.1016\/j.pharmr.2026.100139_bib153","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1172\/JCI74783","article-title":"Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis","volume":"124","author":"Moore-Morris","year":"2014","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib154","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10456-018-9639-0","article-title":"The therapeutic potential of targeting the endothelial-to-mesenchymal transition","volume":"22","author":"Man","year":"2019","journal-title":"Angiogenesis"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib155","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00441-011-1222-6","article-title":"Regulation of endothelial cell plasticity by TGF-\u03b2","volume":"347","author":"van Meeteren","year":"2012","journal-title":"Cell Tissue Res"},{"issue":"3","key":"10.1016\/j.pharmr.2026.100139_bib156","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1042\/BJ20101500","article-title":"Transforming growth factor-\u03b22 promotes Snail-mediated endothelial-mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling","volume":"437","author":"Medici","year":"2011","journal-title":"Biochem J"},{"issue":"6958","key":"10.1016\/j.pharmr.2026.100139_bib157","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nature02006","article-title":"Smad-dependent and Smad-independent pathways in TGF-\u03b2 family signalling","volume":"425","author":"Derynck","year":"2003","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.pharmr.2026.100139_bib158","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1093\/cvr\/cvz211","article-title":"Non-coding RNA in endothelial-to-mesenchymal transition","volume":"115","author":"Hulshoff","year":"2019","journal-title":"Cardiovasc Res"},{"issue":"15","key":"10.1016\/j.pharmr.2026.100139_bib159","doi-asserted-by":"crossref","first-page":"7842","DOI":"10.1093\/nar\/gkz621","article-title":"An expanded landscape of human long noncoding RNA","volume":"47","author":"Jiang","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"18","key":"10.1016\/j.pharmr.2026.100139_bib160","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1101\/gad.17446611","article-title":"Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses","volume":"25","author":"Cabili","year":"2011","journal-title":"Genes Dev"},{"issue":"7414","key":"10.1016\/j.pharmr.2026.100139_bib161","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature11233","article-title":"Landscape of transcription in human cells","volume":"489","author":"Djebali","year":"2012","journal-title":"Nature"},{"issue":"7644","key":"10.1016\/j.pharmr.2026.100139_bib162","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nature21374","article-title":"An atlas of human long non-coding RNAs with accurate 5\u2032 ends","volume":"543","author":"Hon","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib163","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13059-016-0873-8","article-title":"Long non-coding RNAs display higher natural expression variation than protein-coding genes in healthy humans","volume":"17","author":"Kornienko","year":"2016","journal-title":"Genome Biol"},{"issue":"6235","key":"10.1016\/j.pharmr.2026.100139_bib164","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1126\/science.aaa0355","article-title":"The human transcriptome across tissues and individuals","volume":"348","author":"Mel\u00e9","year":"2015","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.pharmr.2026.100139_bib165","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1016\/j.cell.2021.03.050","article-title":"Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease","volume":"184","author":"de Goede","year":"2021","journal-title":"Cell"},{"issue":"D1","key":"10.1016\/j.pharmr.2026.100139_bib166","doi-asserted-by":"crossref","first-page":"D155","DOI":"10.1093\/nar\/gky1141","article-title":"miRBase: from microRNA sequences to function","volume":"47","author":"Kozomara","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib167","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nrg2290","article-title":"Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?","volume":"9","author":"Filipowicz","year":"2008","journal-title":"Nat Rev Genet"},{"issue":"5","key":"10.1016\/j.pharmr.2026.100139_bib168","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.cellsig.2011.12.024","article-title":"Molecular basis of cardiac endothelial-to-mesenchymal transition (EndMT): differential expression of microRNAs during EndMT","volume":"24","author":"Ghosh","year":"2012","journal-title":"Cell Signal"},{"issue":"11","key":"10.1016\/j.pharmr.2026.100139_bib169","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1161\/CIRCRESAHA.106.141986","article-title":"MicroRNA expression signature and antisense-mediated depletion reveal an essential role of microRNA in vascular neointimal lesion formation","volume":"100","author":"Ji","year":"2007","journal-title":"Circ Res"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib170","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1161\/CIRCRESAHA.107.153916","article-title":"Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis","volume":"101","author":"Kuehbacher","year":"2007","journal-title":"Circ Res"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib171","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1161\/ATVBAHA.111.234286","article-title":"Transforming growth factor-\u03b2-induced endothelial-to-mesenchymal transition is partly mediated by microRNA-21","volume":"32","author":"Kumarswamy","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"9","key":"10.1016\/j.pharmr.2026.100139_bib172","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1161\/ATVBAHA.121.313788","article-title":"Endothelial-mesenchymal transition in cardiovascular disease","volume":"41","author":"Alvandi","year":"2021","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"10.1016\/j.pharmr.2026.100139_bib173","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1152\/physrev.1995.75.3.487","article-title":"Regulation of differentiation of vascular smooth muscle cells","volume":"75","author":"Owens","year":"1995","journal-title":"Physiol Rev"},{"issue":"1\u20132","key":"10.1016\/j.pharmr.2026.100139_bib174","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1023\/A:1006941621170","article-title":"Expressional regulation of smooth muscle cell-specific genes in association with phenotypic modulation","volume":"190","author":"Sobue","year":"1999","journal-title":"Mol Cell Biochem"},{"issue":"3","key":"10.1016\/j.pharmr.2026.100139_bib175","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1152\/physrev.00041.2003","article-title":"Molecular regulation of vascular smooth muscle cell differentiation in development and disease","volume":"84","author":"Owens","year":"2004","journal-title":"Physiol Rev"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib176","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1172\/JCI115881","article-title":"Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II","volume":"90","author":"Gibbons","year":"1992","journal-title":"J Clin Invest"},{"issue":"19","key":"10.1016\/j.pharmr.2026.100139_bib177","doi-asserted-by":"crossref","first-page":"7311","DOI":"10.1073\/pnas.83.19.7311","article-title":"Production of platelet-derived growth factor-like molecules by cultured arterial smooth muscle cells accompanies proliferation after arterial injury","volume":"83","author":"Walker","year":"1986","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib178","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/bph.16409","article-title":"Non-coding RNAs to treat vascular smooth muscle cell dysfunction","volume":"182","author":"Brown","year":"2024","journal-title":"Br J Pharmacol"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib179","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.ymthe.2024.12.037","article-title":"Functional screening identifies miRNAs with a novel function inhibiting vascular smooth muscle cell proliferation","volume":"33","author":"Rodor","year":"2025","journal-title":"Mol Ther"},{"issue":"6","key":"10.1016\/j.pharmr.2026.100139_bib180","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1172\/JCI1584","article-title":"Divergent effects of tissue inhibitor of metalloproteinase-1, \u22122, or \u22123 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro. TIMP-3 promotes apoptosis","volume":"101","author":"Baker","year":"1998","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.pharmr.2026.100139_bib181","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1161\/01.CIR.101.3.296","article-title":"Inhibition of late vein graft neointima formation in human and porcine models by adenovirus-mediated overexpression of tissue inhibitor of metalloproteinase-3","volume":"101","author":"George","year":"2000","journal-title":"Circulation"},{"issue":"11_suppl_1","key":"10.1016\/j.pharmr.2026.100139_bib182","doi-asserted-by":"crossref","first-page":"S135","DOI":"10.1161\/CIRCULATIONAHA.110.012732","article-title":"Sustained reduction of vein graft neointima formation by ex vivo TIMP-3 gene therapy","volume":"124","author":"George","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.pharmr.2026.100139_bib183","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ahj.2021.12.009","article-title":"Rationale and design of a randomized trial evaluating an external support device for saphenous vein coronary grafts","volume":"246","author":"Bagiella","year":"2022","journal-title":"Am Heart J"},{"issue":"25","key":"10.1016\/j.pharmr.2026.100139_bib184","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1161\/CIRCULATIONAHA.110.978007","article-title":"Aspirin plus clopidogrel versus aspirin alone after coronary artery bypass grafting: the clopidogrel after surgery for coronary artery disease (CASCADE) Trial","volume":"122","author":"Kulik","year":"2010","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib185","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jvs.2012.06.098","article-title":"Thirty-day vein remodeling is predictive of midterm graft patency after lower extremity bypass","volume":"57","author":"Gasper","year":"2013","journal-title":"J Vasc Surg"},{"issue":"5","key":"10.1016\/j.pharmr.2026.100139_bib186","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1161\/CIRCRESAHA.116.309833","article-title":"Direct reprogramming of human dermal fibroblasts into endothelial cells using ER71\/ETV2","volume":"120","author":"Lee","year":"2017","journal-title":"Circ Res"},{"issue":"6","key":"10.1016\/j.pharmr.2026.100139_bib187","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2024.103574","article-title":"Current evidence on the role of fibroblasts in large-vessel vasculitides: from pathogenesis to therapeutics","volume":"23","author":"Xu","year":"2024","journal-title":"Autoimmun Rev"},{"issue":"7","key":"10.1016\/j.pharmr.2026.100139_bib188","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1093\/cvr\/cvad016","article-title":"Human and murine fibroblast single-cell transcriptomics reveals fibroblast clusters are differentially affected by ageing and serum cholesterol","volume":"119","author":"van Kuijk","year":"2023","journal-title":"Cardiovasc Res"},{"issue":"11","key":"10.1016\/j.pharmr.2026.100139_bib189","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/s41577-021-00540-z","article-title":"Fibroblasts as immune regulators in infection, inflammation and cancer","volume":"21","author":"Davidson","year":"2021","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib190","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s44303-024-00053-z","article-title":"Clinical applications of fibroblast activation protein inhibitor positron emission tomography (FAPI-PET)","volume":"2","author":"Mori","year":"2024","journal-title":"NPJ Imaging"},{"issue":"6","key":"10.1016\/j.pharmr.2026.100139_bib191","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.jacc.2024.10.103","article-title":"Myocardial fibroblast activation after acute myocardial infarction","volume":"85","author":"Barton","year":"2025","journal-title":"J Am Coll Cardiol"},{"issue":"14","key":"10.1016\/j.pharmr.2026.100139_bib192","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/j.jacc.2021.02.019","article-title":"Molecular imaging identifies fibroblast activation beyond the infarct region after acute myocardial infarction","volume":"77","author":"Diekmann","year":"2021","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"10.1016\/j.pharmr.2026.100139_bib193","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.2967\/jnumed.121.263555","article-title":"Cardiac fibroblast activation in patients early after acute myocardial infarction: integration with MR tissue characterization and subsequent functional outcome","volume":"63","author":"Diekmann","year":"2022","journal-title":"J Nucl Med"},{"issue":"6","key":"10.1016\/j.pharmr.2026.100139_bib194","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.pharmr.2026.100139_bib195","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/S0003-4975(99)00729-8","article-title":"Human cytokine responses to coronary artery bypass grafting with and without cardiopulmonary bypass","volume":"68","author":"Str\u00fcber","year":"1999","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.pharmr.2026.100139_bib196","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/fcvm.2018.00003","article-title":"Inflammation in vein graft disease","volume":"5","author":"de Vries","year":"2018","journal-title":"Front Cardiovasc Med"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib197","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1046\/j.1365-2249.1998.00682.x","article-title":"Perioperative cytokine release during coronary artery bypass grafting in patients of different ages","volume":"114","author":"Roth-Isigkeit","year":"1998","journal-title":"Clin Exp Immunol"},{"issue":"6","key":"10.1016\/j.pharmr.2026.100139_bib198","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.bcp.2009.04.029","article-title":"Inflammatory cytokines in vascular dysfunction and vascular disease","volume":"78","author":"Sprague","year":"2009","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.pharmr.2026.100139_bib199","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/9846312","article-title":"Therapeutic targeting of the proinflammatory IL-6-JAK\/STAT signalling pathways responsible for vascular restenosis in type 2 diabetes mellitus","volume":"2019","author":"Moshapa","year":"2019","journal-title":"Cardiol Res Pract"},{"issue":"12","key":"10.1016\/j.pharmr.2026.100139_bib200","doi-asserted-by":"crossref","first-page":"7042","DOI":"10.4049\/jimmunol.165.12.7042","article-title":"Two different epitopes of the signal transducer gp130 sequentially cooperate on IL-6-induced receptor activation","volume":"165","author":"Pflanz","year":"2000","journal-title":"J Immunol"},{"issue":"5143","key":"10.1016\/j.pharmr.2026.100139_bib201","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1126\/science.8272872","article-title":"Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130","volume":"263","author":"L\u00fctticken","year":"1994","journal-title":"Science"},{"issue":"5202","key":"10.1016\/j.pharmr.2026.100139_bib202","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1126\/science.7871433","article-title":"Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors","volume":"267","author":"Stahl","year":"1995","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.pharmr.2026.100139_bib203","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00395-012-0261-9","article-title":"Inhibition of STAT3 signaling prevents vascular smooth muscle cell proliferation and neointima formation","volume":"107","author":"Daniel","year":"2012","journal-title":"Basic Res Cardiol"},{"issue":"32","key":"10.1016\/j.pharmr.2026.100139_bib204","doi-asserted-by":"crossref","first-page":"19641","DOI":"10.1074\/jbc.M114.630111","article-title":"STAT3 protein regulates vascular smooth muscle cell phenotypic switch by interaction with myocardin","volume":"290","author":"Liao","year":"2015","journal-title":"J Biol Chem"},{"issue":"8","key":"10.1016\/j.pharmr.2026.100139_bib205","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrd4088","article-title":"Therapeutic modulators of STAT signalling for human diseases","volume":"12","author":"Miklossy","year":"2013","journal-title":"Nat Rev Drug Discov"},{"issue":"4","key":"10.1016\/j.pharmr.2026.100139_bib206","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1002\/jcb.23452","article-title":"Apigenin attenuates neointima formation via suppression of vascular smooth muscle cell phenotypic transformation","volume":"113","author":"Guan","year":"2012","journal-title":"J Cell Biochem"},{"issue":"6","key":"10.1016\/j.pharmr.2026.100139_bib207","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1161\/01.RES.0000261350.61711.9e","article-title":"An essential role for gp130 in neointima formation following arterial injury","volume":"100","author":"Wang","year":"2007","journal-title":"Circ Res"},{"issue":"28","key":"10.1016\/j.pharmr.2026.100139_bib208","doi-asserted-by":"crossref","first-page":"E2621","DOI":"10.1073\/pnas.1309906110","article-title":"Modulation of reactivation of latent herpes simplex virus 1 in ganglionic organ cultures by p300\/CBP and STAT3","volume":"110","author":"Du","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"10.1016\/j.pharmr.2026.100139_bib209","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1189\/jlb.4A1016-199RR","article-title":"Signal transducer and activator of transcription 3 (Stat3) regulates host defense and protects mice against herpes simplex virus-1 (HSV-1) infection","volume":"101","author":"Hsia","year":"2017","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.pharmr.2026.100139_bib210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/437623","article-title":"Protective function of STAT3 in CVB3-induced myocarditis","volume":"2012","author":"Lindner","year":"2012","journal-title":"Cardiol Res Pract"},{"issue":"1\u20132","key":"10.1016\/j.pharmr.2026.100139_bib211","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.febslet.2004.10.005","article-title":"Tyrosine dephosphorylation of STAT3 in SARS coronavirus-infected Vero E6 cells","volume":"577","author":"Mizutani","year":"2004","journal-title":"FEBS Lett"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib212","doi-asserted-by":"crossref","DOI":"10.1093\/jimmun\/vkaf309","article-title":"STAT3 mediates an inflammation-induced microbial defense response and regulates pathogen control and clearance by macrophages","volume":"215","author":"Patel","year":"2025","journal-title":"J Immunol"},{"issue":"6","key":"10.1016\/j.pharmr.2026.100139_bib213","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.jacc.2011.03.044","article-title":"Hypoxia but not inflammation augments glucose uptake in human macrophages","volume":"58","author":"Folco","year":"2011","journal-title":"J Am Coll Cardiol"},{"issue":"14","key":"10.1016\/j.pharmr.2026.100139_bib214","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/j.jacc.2017.01.060","article-title":"Detection of atherosclerotic inflammation by 68 Ga-DOTATATE PET compared to [18 F]FDG PET imaging","volume":"69","author":"Tarkin","year":"2017","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"10.1016\/j.pharmr.2026.100139_bib215","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1007\/s00259-010-1512-3","article-title":"Procedure guidelines for PET\/CT tumour imaging with 68Ga-DOTA-conjugated peptides: 68Ga-DOTA-TOC, 68Ga-DOTA-NOC, 68Ga-DOTA-TATE","volume":"37","author":"Virgolini","year":"2010","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"17","key":"10.1016\/j.pharmr.2026.100139_bib216","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.3390\/cells11172711","article-title":"A single-cell survey of cellular heterogeneity in human great saphenous veins","volume":"11","author":"Sun","year":"2022","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib217","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1161\/CIRCRESAHA.123.323939","article-title":"Early injury landscape in vein harvest by single-cell and spatial transcriptomics","volume":"135","author":"Michaud","year":"2024","journal-title":"Circ Res"},{"issue":"19","key":"10.1016\/j.pharmr.2026.100139_bib218","doi-asserted-by":"crossref","DOI":"10.3390\/ijms251910368","article-title":"Spatial transcriptomic profiling of human saphenous vein exposed to ex vivo arterial haemodynamics\u2014implications for coronary artery bypass graft patency and vein graft disease","volume":"25","author":"McQueen","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.pharmr.2026.100139_bib219","article-title":"Integrative multiomics analysis of neointima proliferation in human saphenous vein: implications for bypass graft disease","author":"Kim","year":"2023","journal-title":"Preprint"},{"issue":"7","key":"10.1016\/j.pharmr.2026.100139_bib220","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.7150\/thno.77735","article-title":"Multilineage commitment of Sca-1 + cells in reshaping vein grafts","volume":"13","author":"Ni","year":"2023","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.pharmr.2026.100139_bib221","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110080","article-title":"Resident vascular Sca1+ progenitors differentiate into endothelial cells in vascular remodeling via miR-145-5p\/ERG signaling pathway","volume":"27","author":"Ying","year":"2024","journal-title":"iScience"},{"issue":"10","key":"10.1016\/j.pharmr.2026.100139_bib222","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1161\/ATVBAHA.119.312732","article-title":"Single-cell RNA-sequencing and metabolomics analyses reveal the contribution of perivascular adipose tissue stem cells to vascular remodeling","volume":"39","author":"Gu","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"25","key":"10.1016\/j.pharmr.2026.100139_bib223","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1161\/CIRCULATIONAHA.119.043724","article-title":"Systems approach to discovery of therapeutic targets for vein graft disease: PPAR\u03b1 pivotally regulates metabolism, activation, and heterogeneity of macrophages and lesion development","volume":"143","author":"Decano","year":"2021","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.pharmr.2026.100139_bib224","article-title":"Small interfering RNA therapy targeting the long noncoding RNA SMILR for therapeutic intervention in coronary artery bypass graft failure","volume":"10","author":"Brown","year":"2025","journal-title":"JACC Basic Transl Sci"},{"issue":"6","key":"10.1016\/j.pharmr.2026.100139_bib225","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.jtcvs.2004.11.048","article-title":"Modulation of phosphatidylinositol 3-kinase signaling reduces intimal hyperplasia in aortocoronary saphenous vein grafts","volume":"129","author":"Hata","year":"2005","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib226","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/01.ATV.0000151619.54108.a5","article-title":"Adenovirus-mediated intraarterial delivery of PTEN inhibits neointimal hyperplasia","volume":"25","author":"Huang","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib227","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1479-5876-10-2","article-title":"Preventing intimal thickening of vein grafts in vein artery bypass using STAT-3 siRNA","volume":"10","author":"Sun","year":"2012","journal-title":"J Transl Med"},{"issue":"10","key":"10.1016\/j.pharmr.2026.100139_bib228","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/gt.2013.20","article-title":"Inhibition of neointimal hyperplasia in a rabbit vein graft model following non-viral transfection with human iNOS cDNA","volume":"20","author":"Meng","year":"2013","journal-title":"Gene Ther"},{"issue":"5","key":"10.1016\/j.pharmr.2026.100139_bib229","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.ymthe.2004.02.005","article-title":"Overexpression of p53 increases lumen size and blocks neointima formation in porcine interposition vein grafts","volume":"9","author":"Wan","year":"2004","journal-title":"Mol Ther"},{"issue":"5","key":"10.1016\/j.pharmr.2026.100139_bib230","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/S0741-5214(99)70215-6","article-title":"Adenoviral-mediated gene transfer of a constitutively active form of the retinoblastoma gene product attenuates neointimal thickening in experimental vein grafts","volume":"29","author":"Schwartz","year":"1999","journal-title":"J Vasc Surg"},{"issue":"14","key":"10.1016\/j.pharmr.2026.100139_bib231","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1161\/01.CIR.0000014985.50017.6E","article-title":"Accelerated reendothelialization with suppressed thrombogenic property and neointimal hyperplasia of rabbit jugular vein grafts by adenovirus-mediated gene transfer of C-type natriuretic peptide","volume":"105","author":"Ohno","year":"2002","journal-title":"Circulation"},{"issue":"22","key":"10.1016\/j.pharmr.2026.100139_bib232","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1093\/eurheartj\/eht105","article-title":"miRNA-21 is dysregulated in response to vein grafting in multiple models and genetic ablation in mice attenuates neointima formation","volume":"34","author":"McDonald","year":"2013","journal-title":"Eur Heart J"},{"issue":"14","key":"10.1016\/j.pharmr.2026.100139_bib233","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1093\/cvr\/cvae157","article-title":"Inhibition of endothelial-to-mesenchymal transition in a large animal preclinical arteriovenous fistula model leads to improved remodelling and reduced stenosis","volume":"120","author":"Xu","year":"2024","journal-title":"Cardiovasc Res"},{"issue":"19","key":"10.1016\/j.pharmr.2026.100139_bib235","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1001\/jama.294.19.2446","article-title":"Efficacy and safety of edifoligide, an E2F transcription factor decoy, for prevention of vein graft failure following coronary artery bypass graft surgery: PREVENT IV: a randomized controlled trial","volume":"294","author":"Alexander","year":"2005","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.pharmr.2026.100139_bib236","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.jvs.2005.12.058","article-title":"Results of PREVENT III: a multicenter, randomized trial of edifoligide for the prevention of vein graft failure in lower extremity bypass surgery","volume":"43","author":"Conte","year":"2006","journal-title":"J Vasc Surg"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib237","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/eurheartj\/ehaa898","article-title":"Novel antisense therapy targeting microRNA-132 in patients with heart failure: results of a first-in-human phase 1b randomized, double-blind, placebo-controlled study","volume":"42","author":"T\u00e4ubel","year":"2021","journal-title":"Eur Heart J"},{"issue":"15","key":"10.1016\/j.pharmr.2026.100139_bib238","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1161\/CIRCULATIONAHA.121.056929","article-title":"MicroRNA-210 controls mitochondrial metabolism and protects heart function in myocardial infarction","volume":"145","author":"Song","year":"2022","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.pharmr.2026.100139_bib239","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.7150\/ijbs.20254","article-title":"Adenovirus-mediated gene transfer of microRNA-21 sponge inhibits neointimal hyperplasia in rat vein grafts","volume":"13","author":"Wang","year":"2017","journal-title":"Int J Biol Sci"},{"issue":"12","key":"10.1016\/j.pharmr.2026.100139_bib240","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1038\/mt.2010.176","article-title":"Helper-dependent adenoviral vectors are superior in vitro to first-generation vectors for endothelial cell-targeted gene therapy","volume":"18","author":"Flynn","year":"2010","journal-title":"Mol Ther"},{"issue":"6","key":"10.1016\/j.pharmr.2026.100139_bib241","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.jvs.2007.01.066","article-title":"Blockade of monocyte chemoattractant protein-1 by adenoviral gene transfer inhibits experimental vein graft neointimal formation","volume":"45","author":"Tatewaki","year":"2007","journal-title":"J Vasc Surg"},{"issue":"9","key":"10.1016\/j.pharmr.2026.100139_bib242","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/gt.2009.63","article-title":"Adenovirus-mediated gene transfer of fibromodulin inhibits neointimal hyperplasia in an organ culture model of human saphenous vein graft disease","volume":"16","author":"Ranjzad","year":"2009","journal-title":"Gene Ther"},{"issue":"4","key":"10.1016\/j.pharmr.2026.100139_bib244","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.trsl.2012.12.003","article-title":"Gene therapy for the prevention of vein graft disease","volume":"161","author":"Southerland","year":"2013","journal-title":"Transl Res"},{"issue":"6","key":"10.1016\/j.pharmr.2026.100139_bib245","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1172\/JCI118367","article-title":"Adenovirus-mediated gene transfer into normal rabbit arteries results in prolonged vascular cell activation, inflammation, and neointimal hyperplasia","volume":"96","author":"Newman","year":"1995","journal-title":"J Clin Invest"},{"issue":"6","key":"10.1016\/j.pharmr.2026.100139_bib246","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1097\/FJC.0000000000000821","article-title":"Transduction efficiency of adenovirus vectors in endothelial cells and vascular smooth muscle cells","volume":"75","author":"Mokhashi","year":"2020","journal-title":"J Cardiovasc Pharmacol"},{"issue":"5","key":"10.1016\/j.pharmr.2026.100139_bib247","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1089\/hum.2015.019","article-title":"Efficient transduction of primary vascular cells by the rare adenovirus serotype 49 vector","volume":"26","author":"Dakin","year":"2015","journal-title":"Hum Gene Ther"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib248","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jtcvs.2003.07.032","article-title":"Gene delivery to aortocoronary saphenous vein grafts in a large animal model of intimal hyperplasia","volume":"127","author":"Petrofski","year":"2004","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.pharmr.2026.100139_bib249","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.omtm.2017.09.004","article-title":"A rabbit model for testing helper-dependent adenovirus-mediated gene therapy for vein graft atherosclerosis","volume":"7","author":"Bi","year":"2017","journal-title":"Mol Ther Methods Clin Dev"},{"issue":"suppl 1","key":"10.1016\/j.pharmr.2026.100139_bib250","article-title":"Adeno-associated mediated gene transfer for hemophilia B:8 year follow up and impact of removing \u201cempty viral particles\u201d on safety and efficacy of gene transfer","volume":"132","author":"Nathwani","year":"2018","journal-title":"Blood"},{"issue":"13","key":"10.1016\/j.pharmr.2026.100139_bib251","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1182\/blood-2011-09-382317","article-title":"Factor IX expression in skeletal muscle of a severe hemophilia B patient 10 years after AAV-mediated gene transfer","volume":"119","author":"Buchlis","year":"2012","journal-title":"Blood"},{"issue":"9701","key":"10.1016\/j.pharmr.2026.100139_bib252","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/S0140-6736(09)61836-5","article-title":"Age-dependent effects of RPE65 gene therapy for Leber\u2019s congenital amaurosis: a phase 1 dose-escalation trial","volume":"374","author":"Maguire","year":"2009","journal-title":"Lancet"},{"issue":"23","key":"10.1016\/j.pharmr.2026.100139_bib253","doi-asserted-by":"crossref","first-page":"e471","DOI":"10.1161\/CIR.0000000000001296","article-title":"Gene therapy in cardiovascular disease: recent advances and future directions in science: a science advisory from the American Heart Association","volume":"150","author":"Kim","year":"2024","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.pharmr.2026.100139_bib254","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1093\/cvr\/cvaf109","article-title":"Gene therapy in cardiac and vascular diseases: a review of approaches to treat genetic and common cardiovascular diseases with novel gene-based therapeutics","volume":"121","author":"Musolino","year":"2025","journal-title":"Cardiovasc Res"},{"issue":"5","key":"10.1016\/j.pharmr.2026.100139_bib255","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/jgm.535","article-title":"Gene transfer into rabbit arteries with adeno-associated virus and adenovirus vectors","volume":"6","author":"Grucha\u0142a","year":"2004","journal-title":"J Gene Med"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib256","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ymthe.2003.11.006","article-title":"Development of efficient viral vectors selective for vascular smooth muscle cells","volume":"9","author":"Work","year":"2004","journal-title":"Mol Ther"},{"issue":"15\u201316","key":"10.1016\/j.pharmr.2026.100139_bib257","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1089\/hum.2022.211","article-title":"An engineered adeno-associated virus capsid mediates efficient transduction of pericytes and smooth muscle cells of the brain vasculature","volume":"34","author":"Ramirez","year":"2023","journal-title":"Hum Gene Ther"},{"issue":"4","key":"10.1016\/j.pharmr.2026.100139_bib258","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s44161-022-00046-4","article-title":"A high-efficiency AAV for endothelial cell transduction throughout the central nervous system","volume":"1","author":"Krolak","year":"2022","journal-title":"Nat CardioVasc Res"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib259","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41434-024-00511-8","article-title":"AAV library screening identifies novel vector for efficient transduction of human aorta","volume":"32","author":"Schr\u00f6der","year":"2025","journal-title":"Gene Ther"},{"key":"10.1016\/j.pharmr.2026.100139_bib260","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jconrel.2016.05.002","article-title":"Periadventitial drug delivery for the prevention of intimal hyperplasia following open surgery","volume":"233","author":"Chaudhary","year":"2016","journal-title":"J Control Release"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib261","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.jvs.2014.02.037","article-title":"Human type I pancreatic elastase treatment of arteriovenous fistulas in patients with chronic kidney disease","volume":"60","author":"Hye","year":"2014","journal-title":"J Vasc Surg"},{"issue":"10","key":"10.1016\/j.pharmr.2026.100139_bib262","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.3390\/polym16101421","article-title":"Organic nanoparticles in progressing cardiovascular disease treatment and diagnosis","volume":"16","author":"Udri\u015fte","year":"2024","journal-title":"Polymers"},{"issue":"24","key":"10.1016\/j.pharmr.2026.100139_bib263","doi-asserted-by":"crossref","first-page":"6751","DOI":"10.1039\/D3NA00666B","article-title":"Nanomaterials for small diameter vascular grafts: overview and outlook","volume":"5","author":"Wang","year":"2023","journal-title":"Nanoscale Adv"},{"issue":"6","key":"10.1016\/j.pharmr.2026.100139_bib264","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1016\/j.jtcvs.2018.08.115","article-title":"MicroRNA-145-loaded poly(lactic-co-glycolic acid) nanoparticles attenuate venous intimal hyperplasia in a rabbit model","volume":"157","author":"Nishio","year":"2019","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"11","key":"10.1016\/j.pharmr.2026.100139_bib265","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.21037\/jtd.2016.11.14","article-title":"Nanoparticle-mediated arresten gene inhibits neointimal formation of vein grafts: an experimental research","volume":"8","author":"Wang","year":"2016","journal-title":"J Thorac Dis"},{"issue":"5","key":"10.1016\/j.pharmr.2026.100139_bib266","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1163\/1568562053783722","article-title":"Nitric oxide-generating hydrogels inhibit neointima formation","volume":"16","author":"Bohl Masters","year":"2005","journal-title":"J Biomater Sci Polym Ed"},{"issue":"6","key":"10.1016\/j.pharmr.2026.100139_bib267","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.actbio.2005.07.010","article-title":"Localized delivery of nitric oxide from hydrogels inhibits neointima formation in a rat carotid balloon injury model","volume":"1","author":"Lipke","year":"2005","journal-title":"Acta Biomater"},{"issue":"12","key":"10.1016\/j.pharmr.2026.100139_bib268","doi-asserted-by":"crossref","first-page":"776","DOI":"10.3390\/gels8120776","article-title":"Bioadhesive perivascular microparticle-gel drug delivery system for intimal hyperplasia prevention: in vitro evaluation and preliminary biocompatibility assessment","volume":"8","author":"Melnik","year":"2022","journal-title":"Gels"},{"issue":"10","key":"10.1016\/j.pharmr.2026.100139_bib269","doi-asserted-by":"crossref","first-page":"5706","DOI":"10.3390\/ijms23105706","article-title":"Bioadhesive hyaluronic acid\/dopamine hydrogels for vascular applications prepared by initiator-free crosslinking","volume":"23","author":"Melnik","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.pharmr.2026.100139_bib270","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.jvs.2006.04.044","article-title":"Controlled release of small interfering RNA targeting midkine attenuates intimal hyperplasia in vein grafts","volume":"44","author":"Banno","year":"2006","journal-title":"J Vasc Surg"},{"issue":"5","key":"10.1016\/j.pharmr.2026.100139_bib271","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1161\/CIRCRESAHA.108.188425","article-title":"ADAMTS-7 mediates vascular smooth muscle cell migration and neointima formation in balloon-injured rat arteries","volume":"104","author":"Wang","year":"2009","journal-title":"Circ Res"},{"issue":"6121","key":"10.1016\/j.pharmr.2026.100139_bib272","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1231143","article-title":"Multiplex genome engineering using CRISPR\/Cas systems","volume":"339","author":"Cong","year":"2013","journal-title":"Science"},{"issue":"618","key":"10.1016\/j.pharmr.2026.100139_bib273","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abd3079","article-title":"Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations","volume":"13","author":"Fomin","year":"2021","journal-title":"Sci Transl Med"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib274","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1161\/CIRCULATIONAHA.119.042476","article-title":"In vivo AAV-CRISPR\/Cas9-mediated gene editing ameliorates atherosclerosis in familial hypercholesterolemia","volume":"141","author":"Zhao","year":"2020","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib275","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41591-022-02190-7","article-title":"Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice","volume":"29","author":"Reichart","year":"2023","journal-title":"Nat Med"},{"issue":"23","key":"10.1016\/j.pharmr.2026.100139_bib276","doi-asserted-by":"crossref","first-page":"37751","DOI":"10.18632\/oncotarget.17154","article-title":"CRISPR\/Cas9-mediated ApoE -\/- and LDLR -\/- double gene knockout in pigs elevates serum LDL-C and TC levels","volume":"8","author":"Huang","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib277","doi-asserted-by":"crossref","first-page":"8256","DOI":"10.1038\/srep08256","article-title":"Efficient generation of gene-modified pigs via injection of zygote with Cas9\/sgRNA","volume":"5","author":"Wang","year":"2015","journal-title":"Sci Rep"},{"issue":"13","key":"10.1016\/j.pharmr.2026.100139_bib278","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1093\/hmg\/ddv120","article-title":"Functional disruption of the dystrophin gene in rhesus monkey using CRISPR\/Cas9","volume":"24","author":"Chen","year":"2015","journal-title":"Hum Mol Genet"},{"issue":"5","key":"10.1016\/j.pharmr.2026.100139_bib279","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.cell.2024.01.042","article-title":"Past, present, and future of CRISPR genome editing technologies","volume":"187","author":"Pacesa","year":"2024","journal-title":"Cell"},{"issue":"7988","key":"10.1016\/j.pharmr.2026.100139_bib280","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/d41586-023-03590-6","article-title":"UK first to approve CRISPR treatment for diseases: what you need to know","volume":"623","author":"Wong","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.pharmr.2026.100139_bib281","doi-asserted-by":"crossref","DOI":"10.1017\/erm.2025.10","article-title":"Advancing CRISPR genome editing into gene therapy clinical trials: progress and future prospects","volume":"27","author":"Cetin","year":"2025","journal-title":"Expert Rev Mol Med"},{"issue":"7859","key":"10.1016\/j.pharmr.2026.100139_bib282","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/s41586-021-03534-y","article-title":"In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates","volume":"593","author":"Musunuru","year":"2021","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.pharmr.2026.100139_bib283","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/s41587-021-00933-4","article-title":"In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels","volume":"39","author":"Rothgangl","year":"2021","journal-title":"Nat Biotechnol"},{"issue":"3","key":"10.1016\/j.pharmr.2026.100139_bib284","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1161\/CIRCULATIONAHA.122.062132","article-title":"Efficacy and safety of an investigational single-course CRISPR base-editing therapy targeting PCSK9 in nonhuman primate and mouse models","volume":"147","author":"Lee","year":"2023","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.pharmr.2026.100139_bib285","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1080\/13543784.2024.2369747","article-title":"VERVE-101, a CRISPR base-editing therapy designed to permanently inactivate hepatic PCSK9 and reduce LDL-cholesterol","volume":"33","author":"Hooper","year":"2024","journal-title":"Expert Opin Investig Drugs"},{"issue":"3","key":"10.1016\/j.pharmr.2026.100139_bib286","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1056\/NEJMoa1612790","article-title":"Genetic and pharmacologic inactivation of ANGPTL3 and cardiovascular disease","volume":"377","author":"Dewey","year":"2017","journal-title":"N Engl J Med"},{"issue":"21","key":"10.1016\/j.pharmr.2026.100139_bib287","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1056\/NEJMoa2511778","article-title":"Phase 1 trial of CRISPR-Cas9 gene editing targeting ANGPTL3","volume":"393","author":"Laffin","year":"2025","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.pharmr.2026.100139_bib288","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/nbt.3199","article-title":"Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers","volume":"33","author":"Hilton","year":"2015","journal-title":"Nat Biotechnol"},{"issue":"5","key":"10.1016\/j.pharmr.2026.100139_bib289","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nmeth.3325","article-title":"Functional annotation of native enhancers with a Cas9-histone demethylase fusion","volume":"12","author":"Kearns","year":"2015","journal-title":"Nat Methods"},{"issue":"8","key":"10.1016\/j.pharmr.2026.100139_bib290","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.tibtech.2024.02.007","article-title":"CRISPR activation screens: navigating technologies and applications","volume":"42","author":"Clark","year":"2024","journal-title":"Trends Biotechnol"},{"issue":"5","key":"10.1016\/j.pharmr.2026.100139_bib291","doi-asserted-by":"crossref","DOI":"10.1093\/femsre\/fuae020","article-title":"The rise and future of CRISPR-based approaches for high-throughput genomics","volume":"48","author":"Vercauteren","year":"2024","journal-title":"FEMS Microbiol Rev"},{"issue":"43","key":"10.1016\/j.pharmr.2026.100139_bib292","doi-asserted-by":"crossref","first-page":"4610","DOI":"10.1093\/eurheartj\/ehaf703","article-title":"CRISPR activation to repair electrocardiogram abnormalities caused by a FLNC truncating variant in mice","volume":"46","author":"Ca\u00f1as-Alvaro","year":"2025","journal-title":"Eur Heart J"},{"issue":"16","key":"10.1016\/j.pharmr.2026.100139_bib293","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1161\/CIRCULATIONAHA.123.063972","article-title":"CRISPR activation reverses haploinsufficiency and functional deficits caused by TTN truncation variants","volume":"149","author":"Ghahremani","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.pharmr.2026.100139_bib294","article-title":"Desmoplakin haploinsufficiency underlies cell-cell adhesion failure in DSP cardiomyopathy and is rescued by transcriptional activation","author":"Smith","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.pharmr.2026.100139_bib295","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3389\/fcvm.2018.00175","article-title":"Calmodulinopathy: a novel, life-threatening clinical entity affecting the young","volume":"5","author":"Kotta","year":"2018","journal-title":"Front Cardiovasc Med"},{"issue":"12","key":"10.1016\/j.pharmr.2026.100139_bib296","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.3390\/biom11121769","article-title":"CRISPR\/dCas9 transcriptional activation of endogenous apolipoprotein AI and paraoxonase 1 in enterocytes alleviates endothelial cell dysfunction","volume":"11","author":"Toma","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.pharmr.2026.100139_bib297","article-title":"An interplay of non-coding RNAs regulates CDH13 expression and affects endothelial function and coronary artery disease risk","author":"Li","year":"2025","journal-title":"Res Sq"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib298","doi-asserted-by":"crossref","first-page":"8363","DOI":"10.1038\/s41467-025-62285-w","article-title":"Mechanically activated snai1b coordinates the initiation of myocardial delamination for trabeculation","volume":"16","author":"Wang","year":"2025","journal-title":"Nat Commun"},{"issue":"8","key":"10.1016\/j.pharmr.2026.100139_bib299","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1161\/CIRCRESAHA.120.318124","article-title":"MIR503HG loss promotes endothelial-to-mesenchymal transition in vascular disease","volume":"128","author":"Monteiro","year":"2021","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmr.2026.100139_bib300","doi-asserted-by":"crossref","DOI":"10.1016\/j.vph.2025.107521","article-title":"Targeting Cis-regulatory elements for CRISPR-mediated transcriptional activation of the human MIR503HG locus","volume":"160","author":"Monteiro","year":"2025","journal-title":"Vasc Pharmacol"},{"issue":"10","key":"10.1016\/j.pharmr.2026.100139_bib301","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1161\/ATVBAHA.124.322353","article-title":"Effective transcriptional induction of the CARMN\/miR-143\/145 complex locus in smooth muscle cells using CRISPR activation","volume":"45","author":"Vacante","year":"2025","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"9","key":"10.1016\/j.pharmr.2026.100139_bib302","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1161\/CIRCRESAHA.120.318688","article-title":"CARMN loss regulates smooth muscle cells and accelerates atherosclerosis in mice","volume":"128","author":"Vacante","year":"2021","journal-title":"Circ Res"},{"issue":"23","key":"10.1016\/j.pharmr.2026.100139_bib303","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1161\/CIRCULATIONAHA.121.055949","article-title":"CARMN is an evolutionarily conserved smooth muscle cell-specific LncRNA that maintains contractile phenotype by binding myocardin","volume":"144","author":"Dong","year":"2021","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.pharmr.2026.100139_bib304","first-page":"519","article-title":"A new vascular prosthesis for a small caliber artery","volume":"74","author":"Matsumoto","year":"1973","journal-title":"Surgery"},{"issue":"4","key":"10.1016\/j.pharmr.2026.100139_bib305","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s11517-007-0176-z","article-title":"Achieving the ideal properties for vascular bypass grafts using a tissue engineered approach: a review","volume":"45","author":"Sarkar","year":"2007","journal-title":"Med Bio Eng Comput"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib306","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/0741-5214(87)90148-0","article-title":"Effect of compliance mismatch on vascular graft patency","volume":"5","author":"Abbott","year":"1987","journal-title":"J Vasc Surg"},{"issue":"7","key":"10.1016\/j.pharmr.2026.100139_bib307","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1056\/NEJM200102153440717","article-title":"Transplantation of a tissue-engineered pulmonary artery","volume":"344","author":"Shin'oka","year":"2001","journal-title":"N Engl J Med"},{"issue":"5413","key":"10.1016\/j.pharmr.2026.100139_bib308","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1126\/science.284.5413.489","article-title":"Functional arteries grown in vitro","volume":"284","author":"Niklason","year":"1999","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.pharmr.2026.100139_bib309","doi-asserted-by":"crossref","first-page":"659","DOI":"10.3727\/000000003108747136","article-title":"Decellularized native and engineered arterial scaffolds for transplantation","volume":"12","author":"Dahl","year":"2003","journal-title":"Cell Transplant"},{"key":"10.1016\/j.pharmr.2026.100139_bib310","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fbioe.2015.00043","article-title":"A review of cellularization strategies for tissue engineering of whole organs","volume":"3","author":"Scarritt","year":"2015","journal-title":"Front Bioeng Biotechnol"},{"issue":"5","key":"10.1016\/j.pharmr.2026.100139_bib311","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S0142-9612(03)00593-3","article-title":"Aligned biodegradable nanofibrous structure: a potential scaffold for blood vessel engineering","volume":"25","author":"Xu","year":"2004","journal-title":"Biomaterials"},{"issue":"10","key":"10.1016\/j.pharmr.2026.100139_bib312","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.3390\/ijms21103444","article-title":"Bioresorbable polymeric scaffold in cardiovascular applications","volume":"21","author":"Toong","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10.1016\/j.pharmr.2026.100139_bib313","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.biomaterials.2005.06.020","article-title":"Microintegrating smooth muscle cells into a biodegradable, elastomeric fiber matrix","volume":"27","author":"Stankus","year":"2006","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.pharmr.2026.100139_bib314","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1002\/biot.200600081","article-title":"Application of inkjet printing to tissue engineering","volume":"1","author":"Boland","year":"2006","journal-title":"Biotechnol J"},{"issue":"23","key":"10.1016\/j.pharmr.2026.100139_bib315","article-title":"Fabrication of a compliant vascular graft using extrusion printing and electrospinning technique","volume":"9","author":"Fazal","year":"2024","journal-title":"Adv Mater Technol"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib316","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.actbio.2010.07.022","article-title":"A multilayered synthetic human elastin\/polycaprolactone hybrid vascular graft with tailored mechanical properties","volume":"7","author":"Wise","year":"2011","journal-title":"Acta Biomater"},{"issue":"15","key":"10.1016\/j.pharmr.2026.100139_bib317","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1096\/fj.02-1041fje","article-title":"Cell-demanded release of VEGF from synthetic, biointeractive cell-ingrowth matrices for vascularized tissue growth","volume":"17","author":"Zisch","year":"2003","journal-title":"FASEB J"},{"issue":"14","key":"10.1016\/j.pharmr.2026.100139_bib318","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.biomaterials.2004.06.006","article-title":"Polymers incorporating nitric oxide releasing\/generating substances for improved biocompatibility of blood-contacting medical devices","volume":"26","author":"Frost","year":"2005","journal-title":"Biomaterials"},{"issue":"68","key":"10.1016\/j.pharmr.2026.100139_bib319","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3001426","article-title":"Readily available tissue-engineered vascular grafts","volume":"3","author":"Dahl","year":"2011","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.pharmr.2026.100139_bib320","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.actbio.2019.03.025","article-title":"Elucidating the role of graft compliance mismatch on intimal hyperplasia using an ex vivo organ culture model","volume":"89","author":"Post","year":"2019","journal-title":"Acta Biomater"},{"issue":"10","key":"10.1016\/j.pharmr.2026.100139_bib321","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1089\/ten.tec.2019.0086","article-title":"Optimization of tissue-engineered vascular graft design using computational modeling","volume":"25","author":"Szafron","year":"2019","journal-title":"Tissue Eng C"},{"issue":"3","key":"10.1016\/j.pharmr.2026.100139_bib322","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/cells6030019","article-title":"Vascular Mechanobiology: towards control of in situ regeneration","volume":"6","author":"van Haaften","year":"2017","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.pharmr.2026.100139_bib323","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1007\/s10439-018-1977-y","article-title":"VascuTrainer: a mobile and disposable bioreactor system for the conditioning of tissue-engineered vascular grafts","volume":"46","author":"Wolf","year":"2018","journal-title":"Ann Biomed Eng"},{"issue":"4","key":"10.1016\/j.pharmr.2026.100139_bib324","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.jvs.2019.11.056","article-title":"Arterial reconstruction with human bioengineered acellular blood vessels in patients with peripheral arterial disease","volume":"72","author":"Gutowski","year":"2020","journal-title":"J Vasc Surg"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib325","first-page":"81","article-title":"History, progress and future challenges of artificial blood vessels: a narrative review","volume":"3","author":"Hu","year":"2022","journal-title":"Biomater Transl"},{"issue":"2","key":"10.1016\/j.pharmr.2026.100139_bib326","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jvs.2005.10.037","article-title":"Heparin-bonded expanded polytetrafluoroethylene vascular graft for femoropopliteal and femorocrural bypass grafting: 1-year results","volume":"43","author":"Bosiers","year":"2006","journal-title":"J Vasc Surg"},{"issue":"1","key":"10.1016\/j.pharmr.2026.100139_bib327","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jvs.2015.11.049","article-title":"Prevention of vein graft intimal hyperplasia with photochemical tissue passivation","volume":"65","author":"Salinas","year":"2017","journal-title":"J Vasc Surg"},{"issue":"8","key":"10.1016\/j.pharmr.2026.100139_bib328","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.003856","article-title":"Photochemical tissue passivation reduces vein graft intimal hyperplasia in a swine model of arteriovenous bypass grafting","volume":"5","author":"Goldstone","year":"2016","journal-title":"J Am Heart Assoc"}],"container-title":["Pharmacological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003169972600027X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003169972600027X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:25:10Z","timestamp":1785147910000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S003169972600027X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":326,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S003169972600027X"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmr.2026.100139","relation":{},"ISSN":["0031-6997"],"issn-type":[{"value":"0031-6997","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vein graft failure: Pathophysiology, detection, prevention and emerging therapeutic strategies","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmr.2026.100139","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of American Society for Pharmacology and Experimental Therapeutics.","name":"copyright","label":"Copyright"}],"article-number":"100139"}}