{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:02:54Z","timestamp":1791216174079,"version":"4.1.0"},"reference-count":303,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1016\/j.pharmthera.2005.08.013","type":"journal-article","created":{"date-parts":[[2005,10,14]],"date-time":"2005-10-14T11:14:48Z","timestamp":1129288488000},"page":"433-454","source":"Crossref","is-referenced-by-count":191,"title":["Purinergic P2 receptors as targets for novel analgesics"],"prefix":"10.1016","volume":"110","author":[{"given":"Geoffrey","family":"Burnstock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharmthera.2005.08.013_bib1","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1177\/00220345010800021501","article-title":"Immunohistochemical evidence for ATP receptors in human dental pulp","volume":"80","author":"Alavi","year":"2001","journal-title":"J Dental Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0306-4522(99)00388-7","article-title":"Functional cross-excitation between afferent A- and C-neurons in dorsal root ganglia","volume":"95","author":"Amir","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1080\/003655902320766006","article-title":"Overactive bladder-pharmacological aspects","author":"Andersson","year":"2002","journal-title":"Scand J Urol Nephrol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0090-4295(02)01786-7","article-title":"Pharmacologic perspective on the physiology of the lower urinary tract","volume":"60","author":"Andersson","year":"2002","journal-title":"Urology"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib5","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S0006-8993(03)03365-1","article-title":"P2X3-immunoreactive primary sensory neurons innervating lumbar intervertebral disc in rats","volume":"989","author":"Aoki","year":"2003","journal-title":"Brain Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1046\/j.1600-0854.2003.00156.x","article-title":"The uroepithelium: not just a passive barrier","volume":"5","author":"Apodaca","year":"2004","journal-title":"Traffic"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib299","doi-asserted-by":"crossref","first-page":"9840","DOI":"10.1073\/pnas.152588599","article-title":"Intercellular calcium signaling mediated by point-source burst release of ATP","volume":"99","author":"Arcuino","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib300","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.urology.2004.10.057","article-title":"Effect of botulinum toxin on detrusor overactivity induced by intravesical adenosine triphosphate and capsaicin in a rat model","volume":"65","author":"Atiemo","year":"2005","journal-title":"Urology"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib7","doi-asserted-by":"crossref","first-page":"7493","DOI":"10.1523\/JNEUROSCI.22-17-07493.2002","article-title":"Dynamic pattern of reg-2 expression in rat sensory neurons after peripheral nerve injury","volume":"22","author":"Averill","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib8","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/ddr.10148","article-title":"Suppression of experimental zymosan-induced arthritis by intraperitoneal administration of adenosine","volume":"57","author":"Baharav","year":"2002","journal-title":"Drug Dev Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib9","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1046\/j.1464-410X.2003.03065.x","article-title":"Bladder electrical activity: the elusive electromyogram","volume":"92","author":"Ballaro","year":"2003","journal-title":"BJU Int"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.febslet.2004.07.009","article-title":"Pannexin membrane channels are mechanosensitive conduits for ATP","volume":"572","author":"Bao","year":"2004","journal-title":"FEBS Lett"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib11","doi-asserted-by":"crossref","first-page":"8139","DOI":"10.1523\/JNEUROSCI.22-18-08139.2002","article-title":"Functional downregulation of P2X3 receptor subunit in rat sensory neurons reveals a significant role in chronic neuropathic and inflammatory pain","volume":"22","author":"Barclay","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib12","first-page":"95","article-title":"Excitatory synaptic transmission in neonatal dorsal horn: NMDA and ATP receptors","volume":"16","author":"Bardoni","year":"2001","journal-title":"News Physiol Sci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib13","unstructured":"Barrick, S., Kiss, S., Roppolo, J. R., de Groat, W. C., Buffington, C. A., Birder, L. A. (2002). Altered mechanosensitive ATP release from urothelium in cats with feline interstitial cystitis (FIC) [Abstract]. Proceedings of Society of Neuroscience, November, Orlando."},{"key":"10.1016\/j.pharmthera.2005.08.013_bib301","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1046\/j.1460-9568.1999.00458.x","article-title":"Stability and plasticity of primary afferent projections following nerve regeneration and central degeneration","volume":"11","author":"Belyantseva","year":"1999","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib14","unstructured":"Bergson, P., & Cook, S. P. (2004). P2Y2 receptors modulate excitability of sensory neurons through inhibition of KCNQ. Program No. 285.10 2004. Abstract Viewer\/Itinerary Planner. Washington, DC: Society for Neuroscience."},{"key":"10.1016\/j.pharmthera.2005.08.013_bib15","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.1523\/JNEUROSCI.22-12-04767.2002","article-title":"ATP as a putative sensory mediator: activation of intrinsic sensory neurons of the myenteric plexus via P2X receptors","volume":"22","author":"Bertrand","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib16","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1113\/jphysiol.2003.044172","article-title":"Peristalsis is impaired in the small intestine of mice lacking the P2X3 subunit","volume":"551","author":"Bian","year":"2003","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib17","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/nn902","article-title":"Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1","volume":"5","author":"Birder","year":"2002","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib18","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0304-3959(77)90066-5","article-title":"Observations on the algogenic actions of adenosine compounds on human blister base preparation","volume":"3","author":"Bleehen","year":"1977","journal-title":"Pain"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib19","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1097\/00001756-199904060-00037","article-title":"Localization of ATP-gated P2X2 and P2X3 receptor immunoreactive nerves in rat taste buds","volume":"10","author":"Bo","year":"1999","journal-title":"NeuroReport"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib20","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1097\/00001756-200109170-00034","article-title":"ATP-induced movement of the stalks of isolated cochlear Deiters' cells","volume":"12","author":"Bobbin","year":"2001","journal-title":"NeuroReport"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib21","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1097\/00005344-200112000-00012","article-title":"Evidence that release of ATP from endothelial cells during increased shear stress is vesicular","volume":"38","author":"Bodin","year":"2001","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib22","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1023\/A:1012388618693","article-title":"Purinergic signalling: ATP release","volume":"26","author":"Bodin","year":"2001","journal-title":"Neurochem Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/syn.10156","article-title":"P2Y receptor-mediated inhibition of voltage-dependent Ca2+ channels in rat dorsal root ganglion neurons","volume":"47","author":"Borvendeg","year":"2003","journal-title":"Synapse"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib24","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.1365-2680.2001.00235.x","article-title":"Bladder instability: a re-appraisal of classical experimental approaches and development of new therapeutic strategies","volume":"21","author":"Boselli","year":"2001","journal-title":"J Auton Pharm"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib25","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1002\/art.10595","article-title":"Spinal adenosine receptor activation inhibits inflammation and joint destruction in rat adjuvant-induced arthritis","volume":"46","author":"Boyle","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib26","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1006\/mcne.1998.0719","article-title":"The expression of P2X3 purinoceptors in sensory neurons: effects of axotomy and glial-derived neurotrophic factor","volume":"12","author":"Bradbury","year":"1998","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib27","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.eururo.2003.12.017","article-title":"P2X3-immunoreactive nerve fibres in neurogenic detrusor overactivity and the effect of intravesical resiniferatoxin","volume":"46","author":"Brady","year":"2004","journal-title":"Eur Urol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib28","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0169-328X(98)00159-4","article-title":"Gene expression of the P2X receptors in the rat retina","volume":"59","author":"Br\u00e4ndle","year":"1998","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib29","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1165\/ajrcmb.23.1.3936","article-title":"Intraepithelial vagal sensory nerve terminals in rat pulmonary neuroepithelial bodies express P2X3 receptors","volume":"23","author":"Brouns","year":"2000","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib30","first-page":"80","article-title":"Ontogenesis of P2X3 receptor-expressing nerve fibres in the rat lung, with special reference to neuroepithelial bodies","volume":"14","author":"Brouns","year":"2003","journal-title":"Biomed Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib31","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1165\/rcmb.2002-0117OC","article-title":"Dual sensory innervation of pulmonary neuroepithelial bodies","volume":"28","author":"Brouns","year":"2003","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib32","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cbpb.2004.11.007","article-title":"Hyperthyroidism changes nociceptive response and ecto-nucleotidase activities in synaptosomes from spinal cord of rats in different phases of development","volume":"140","author":"Bruno","year":"2005","journal-title":"Comp Biochem Physiol Part A"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib33","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1124\/mol.58.6.1502","article-title":"Competitive antagonism of recombinant P2X2\/3 receptors by 2\u2032,3\u2032-O-(2,4,6-trinitrophenyl) adenosine 5\u2032-triphosphate (TNP-ATP)","volume":"58","author":"Burgard","year":"2000","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib34","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/S0140-6736(81)92572-1","article-title":"Pathophysiology of migraine: a new hypothesis","volume":"i","author":"Burnstock","year":"1981","journal-title":"Lancet"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib35","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/0753-3322(89)90161-3","article-title":"The role of adenosine triphosphate in migraine","volume":"43","author":"Burnstock","year":"1989","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib36","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1016\/S0140-6736(96)91082-X","article-title":"A unifying purinergic hypothesis for the initiation of pain","volume":"347","author":"Burnstock","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib37","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1046\/j.1469-7580.1999.19430335.x","article-title":"Release of vasoactive substances from endothelial cells by shear stress and purinergic mechanosensory transduction","volume":"194","author":"Burnstock","year":"1999","journal-title":"J Anat"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib38","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/oxfordjournals.bja.a013473","article-title":"P2X receptors in sensory neurones","volume":"84","author":"Burnstock","year":"2000","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib39","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0165-6147(00)01643-6","article-title":"Purine-mediated signalling in pain and visceral perception","volume":"22","author":"Burnstock","year":"2001","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib40","series-title":"Handbook of Experimental Pharmacology","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/978-3-642-56921-0_6","article-title":"Purinergic signalling in lower urinary tract","volume":"Vol. 151\/I","author":"Burnstock","year":"2001"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ddr.1093","article-title":"Expanding field of purinergic signaling","volume":"52","author":"Burnstock","year":"2001","journal-title":"Drug Dev Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib42","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/S0959-4388(96)80060-2","article-title":"Purinergic receptors: their role in nociception and primary afferent neurotransmission","volume":"6","author":"Burnstock","year":"1996","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib43","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.bbrc.2004.07.081","article-title":"Detection of hypoxia-evoked ATP release from chemoreceptor cells of the rat carotid body","volume":"322","author":"Buttigieg","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib44","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1046\/j.1526-4637.2001.002001015.x","article-title":"Functional interactions between tumor and peripheral nerve in a model of cancer pain in the mouse","volume":"2","author":"Cain","year":"2001","journal-title":"Pain Med"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib45","first-page":"1227","article-title":"Increase of purinergic receptor P2X7 in injured human nerves and dorsal root ganglia","volume":"75","author":"Casula","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib46","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1126\/science.288.5464.306","article-title":"Impaired nociception and pain sensation in mice lacking the capsaicin receptor","volume":"288","author":"Caterina","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib47","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1523\/JNEUROSCI.22-08-03061.2002","article-title":"ADP and AMP induce interleukin-1beta release from microglial cells through activation of ATP-primed P2X7 receptor channels","volume":"22","author":"Chakfe","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib48","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/377428a0","article-title":"A P2X purinoceptor expressed by a subset of sensory neurons","volume":"377","author":"Chen","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib49","unstructured":"Chen, Y., Li, G., & Huang, L. M. (2004) Sensitization of P2X receptors in DRGs after nerve injury. Program No. 285.7 2004. Abstract Viewer\/Itinerary Planner. Washington, DC: Society for Neuroscience."},{"key":"10.1016\/j.pharmthera.2005.08.013_bib50","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.pain.2005.01.002","article-title":"Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain","volume":"114","author":"Chessell","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib51","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0031-6997(24)01512-6","article-title":"P2X receptors and nociception","volume":"53","author":"Chizh","year":"2000","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib52","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.neuropharm.2004.12.009","article-title":"Opioids inhibit purinergic nociceptors in the sensory neurons and fibres of rat via a G protein-dependent mechanism","volume":"48","author":"Chizhmakov","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib53","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/35039519","article-title":"Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice","volume":"407","author":"Cockayne","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib54","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/212411a0","article-title":"Antagonism by aspirin and fenamates of bronchoconstriction and nociception induced by adenosine-5\u2032-triphosphate","volume":"212","author":"Collier","year":"1966","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib55","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0304-3959(01)00372-4","article-title":"Cell damage excites nociceptors through release of cytosolic ATP","volume":"95","author":"Cook","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib56","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/387505a0","article-title":"Distinct ATP receptors on pain-sensing and stretch-sensing neurons","volume":"387","author":"Cook","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib57","first-page":"43","article-title":"\u201cThe force be with you\u201d: ATP in gut mechanosensory transduction","volume":"18","author":"Cooke","year":"2003","journal-title":"News Physiol Sci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib58","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0885-3924(99)00135-9","article-title":"The safety and efficacy of a single dose (500 mg or 1 g) of intravenous magnesium sulfate in neuropathic pain poorly responsive to strong opioid analgesics in patients with cancer","volume":"19","author":"Crosby","year":"2000","journal-title":"J Pain Symptom Manag"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib59","unstructured":"Dai, Y., Fukuoka, T., Tokunaga, A., Noguchi, J. (2002). P2X receptors mediate mechanical stimulation-evoked pain signaling in DRG neurons in inflammation [Abstract]. Proceedings of Society of Neuroscience, November, Orlando 52.13."},{"key":"10.1016\/j.pharmthera.2005.08.013_bib60","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.pain.2003.12.034","article-title":"Contribution of sensitized P2X receptors in inflamed tissue to the mechanical hypersensitivity revealed by phosphorylated ERK in DRG neurons","volume":"108","author":"Dai","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib61","unstructured":"Dang, K., Bielefedlt, K., & Gebhart, G.F. (2004). Distinct P2X receptors on thoracolumbar and lumbosacral dorsal root ganglion neurons innervating the rat urinary bladder. Program No. 2856.1 2004. Abstract Viewer\/Itinerary Planner. Washington, DC: Society for Neuroscience."},{"key":"10.1016\/j.pharmthera.2005.08.013_bib62","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1002\/art.10678","article-title":"Relief of inflammatory pain in rats by local use of the selective P2X7 ATP receptor inhibitor, oxidized ATP","volume":"46","author":"Dell'Antonio","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib63","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0304-3940(02)00385-3","article-title":"Antinociceptive effect of a new P(2Z)\/P2X7 antagonist, oxidized ATP, in arthritic rats","volume":"327","author":"Dell'Antonio","year":"2002","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib64","unstructured":"Deltoff, M. R., Fisher, L. C., Kloos, Z. A., Kloos, A. D., Miller, E. L., McGaughy, V., et al. (2004). Neuropathic pain after spinal cord injury and its relationship to glia and ATP receptor upregulation. Program No. 458.5 2004. Abstract Viewer\/Itinerary Planner. Washington, DC: Society for Neuroscience."},{"key":"10.1016\/j.pharmthera.2005.08.013_bib65","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/sj.bjp.0705218","article-title":"Alteration of the purinergic modulation of enteric neurotransmission in the mouse ileum during chronic intestinal inflammation","volume":"139","author":"De Man","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib66","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1113\/jphysiol.2003.046078","article-title":"Dehydroepiandrosterone potentiates native ionotropic ATP receptors containing the P2X2 subunit in rat sensory neurones","volume":"552","author":"De Roo","year":"2003","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib67","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/ddr.10191","article-title":"Extracellular ATP, receptors and inflammation","volume":"59","author":"Di Virgilio","year":"2003","journal-title":"Drug Dev Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib68","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1089\/108729001300338690","article-title":"Specific inhibition of the rat ligand-gated ion channel P2X3 function via methoxyethoxy-modified phosphorothioated antisense oligonucleotides","volume":"11","author":"Dorn","year":"2001","journal-title":"Antisense Nucleic Acid Drug Dev"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib69","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1093\/nar\/gnh044","article-title":"siRNA relieves chronic neuropathic pain","volume":"32","author":"Dorn","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib70","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/sj.bjp.0702080","article-title":"P2X receptor-mediated excitation of nociceptive afferents in the normal and arthritic rat knee joint","volume":"125","author":"Dowd","year":"1998","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib71","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0301-0082(01)00005-3","article-title":"P2X receptors in peripheral neurones","volume":"65","author":"Dunn","year":"2001","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib72","doi-asserted-by":"crossref","first-page":"53109","DOI":"10.1074\/jbc.M409772200","article-title":"Identification of negative residues in the P2X3 ATP receptor ectodomain as structural determinants for desensitization and the Ca2+-sensing modulatory sites","volume":"279","author":"Fabbretti","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib73","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1469-7793.1997.503bb.x","article-title":"ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes\u2014a possible sensory mechanism?","volume":"505","author":"Ferguson","year":"1997","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib74","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1046\/j.1471-4159.2003.01716.x","article-title":"Characterization of P2X3, P2Y1 and P2Y4 receptors in cultured HEK293-hP2X3 cells and their inhibition by ethanol and trichloroethanol","volume":"85","author":"Fischer","year":"2003","journal-title":"J Neurochem"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib75","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0306-4522(02)00237-3","article-title":"Immunoreactive localisation of P2Y1 receptors within the rat and human nodose ganglia and rat brainstem: comparison with [\u03b133P]deoxyadenosine 5\u2032-triphosphate autoradiography","volume":"113","author":"Fong","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib76","doi-asserted-by":"crossref","first-page":"S172","DOI":"10.1053\/j.gastro.2003.10.006","article-title":"The perspective of a neurologist on treatment-related research in fecal and urinary incontinence","volume":"126","author":"Fowler","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib77","first-page":"51","article-title":"Urinary incontinence: neuropharmacological approaches","volume":"Vol. 38","author":"Fraser","year":"2003"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib78","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.urology.2003.10.031","article-title":"Control of bladder function by peripheral nerves: avenues for novel drug targets","volume":"63","author":"Fry","year":"2004","journal-title":"Urology"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib79","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0006-8993(99)01186-5","article-title":"Microglial reactions after subcutaneous formalin injection into the rat hind paw","volume":"825","author":"Fu","year":"1999","journal-title":"Brain Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib80","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1515\/BC.2004.022","article-title":"Expression of functional purinergic receptors in pulmonary neuroepithelial bodies and their role in hypoxia chemotransmission","volume":"385","author":"Fu","year":"2004","journal-title":"Biol Chem"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib81","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1254\/jjp.86.423","article-title":"Involvement of \u03b22-adrenergic and \u03bc-opioid receptors in antinociception produced by intracerebroventricular administration of \u03b1,\u03b2-methylene-ATP","volume":"86","author":"Fukui","year":"2001","journal-title":"Jpn J Pharmacol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib82","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1254\/jphs.94.153","article-title":"Involvement of locus coeruleus noradrenergic neurons in supraspinal antinociception by \u03b1,\u03b2-methylene-ATP in rats","volume":"94","author":"Fukui","year":"2004","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib83","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1385\/MN:26:1:057","article-title":"Contribution of the spared primary afferent neurons to the pathomechanisms of neuropathic pain","volume":"26","author":"Fukuoka","year":"2002","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0301-0082(97)00051-8","article-title":"Intrinsic primary afferent neurons of the intestine","volume":"54","author":"Furness","year":"1998","journal-title":"Prog Neurol Biol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib85","doi-asserted-by":"crossref","first-page":"6890","DOI":"10.1073\/pnas.81.21.6890","article-title":"Is ATP a central synaptic mediator for certain primary afferent fibres from mammalian skin?","volume":"81","author":"Fyffe","year":"1984","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib86","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/sj.bjp.0705761","article-title":"Enteric P2X receptors as potential targets for drug treatment of the irritable bowel syndrome","volume":"141","author":"Galligan","year":"2004","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib87","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00441-004-0979-2","article-title":"Immunolocalisation of P2X and P2Y nucleotide receptors in the rat nasal mucosa","volume":"319","author":"Gayle","year":"2005","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib88","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1046\/j.1471-4159.2003.01995.x","article-title":"P2X7 nucleotide receptor activation enhances IFN gamma-induced type II nitric oxide synthase activity in BV-2 microglial cells","volume":"87","author":"Gendron","year":"2003","journal-title":"J Neurochem"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib89","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11302-004-4740-9","article-title":"P2Y receptors and pain transmission","volume":"1","author":"Gerevich","year":"2004","journal-title":"Purinergic Signalling"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib90","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1523\/JNEUROSCI.4019-03.2004","article-title":"Inhibition of N-type voltage-activated calcium channels in rat dorsal root ganglion neurons by P2Y receptors is a possible mechanism of ADP-induced analgesia","volume":"24","author":"Gerevich","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib91","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.brainres.2005.02.081","article-title":"Re-organization of P2X3 receptor localization on epidermal nerve fibers in a murine model of cancer pain","volume":"1044","author":"Gilchrist","year":"2005","journal-title":"Brain Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib92","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0028-3908(02)00338-6","article-title":"Modulation of P2X3 receptors by Mg2+ on rat DRG neurons in culture","volume":"44","author":"Giniatullin","year":"2003","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib93","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0028-3908(97)00108-1","article-title":"Mechanically and ATP-induced currents of mouse outer hair cells are independent and differentially blocked by d-tubocurarine","volume":"36","author":"Glowatzki","year":"1997","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib94","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.2741\/1301","article-title":"Fever in systemic inflammation: roles of purines","volume":"9","author":"Gourine","year":"2004","journal-title":"Front Biosci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib95","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature03690","article-title":"ATP is a mediator of chemosensory transduction in the central nervous system","volume":"436","author":"Gourine","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib96","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1073\/pnas.88.10.4162","article-title":"Purinergic regulation of bradykinin-induced plasma extravasation and adjuvant-induced arthritis in the rat","volume":"88","author":"Green","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib97","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1046\/j.1523-1747.2003.12261.x","article-title":"Purinergic receptors are part of a functional signalling system for proliferation and differentiation of human epidermal keratinocytes","volume":"120","author":"Greig","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib98","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1177\/1073858403252788","article-title":"P2X receptor-mediated modulation of sensory transmission to the spinal cord dorsal horn","volume":"9","author":"Gu","year":"2003","journal-title":"Neuroscientist"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib99","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11302-004-4743-6","article-title":"P2X receptor-mediated purinergic sensory pathways to the spinal cord dorsal horn","volume":"1","author":"Gu","year":"2004","journal-title":"Purinergic Signalling"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib100","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1046\/j.1460-9568.1999.00503.x","article-title":"Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites","volume":"11","author":"Guo","year":"1999","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib101","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1469-7793.2001.00437.x","article-title":"Selective activation of nociceptors by P2X receptor agonists in normal and inflamed rat skin","volume":"534","author":"Hamilton","year":"2001","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib102","doi-asserted-by":"crossref","first-page":"8291","DOI":"10.1523\/JNEUROSCI.23-23-08291.2003","article-title":"Activation of purinergic receptor subtypes modulates odor sensitivity","volume":"23","author":"Hegg","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib103","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1093\/nar\/gkg322","article-title":"Independent combinatorial effect of antisense oligonucleotides and RNAi-mediated specific inhibition of the recombinant rat P2X3 receptor","volume":"31","author":"Hemmings-Mieszczak","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib104","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0304-3959(01)00469-9","article-title":"ATP responses in human C nociceptors","volume":"98","author":"Hilliges","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib105","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1152\/jn.2002.88.3.1212","article-title":"Coexistence of functional IP(3) and ryanodine receptors in vagal sensory neurons and their activation by ATP","volume":"88","author":"Hoesch","year":"2002","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib106","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.pain.2004.03.043","article-title":"Acidic pH and capsaicin activate mechanosensitive group IV muscle receptors in the rat","volume":"110","author":"Hoheisel","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib107","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0014-2999(01)01319-X","article-title":"Gastrointestinal afferents as targets of novel drugs for the treatment of functional bowel disorders and visceral pain","volume":"429","author":"Holzer","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib108","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.coph.2003.06.008","article-title":"Acid-sensitive ion channels in gastrointestinal function","volume":"3","author":"Holzer","year":"2003","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib109","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1517\/14728222.8.2.107","article-title":"Gastrointestinal pain in functional bowel disorders: sensory neurons as novel drug targets","volume":"8","author":"Holzer","year":"2004","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib110","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0304-3959(02)00032-5","article-title":"Analgesic profile of intrathecal P2X3 antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats","volume":"99","author":"Honore","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib111","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0304-3959(01)00434-1","article-title":"TNP-ATP, a potent P2X3 receptor antagonist, blocks acetic acid-induced abdominal constriction in mice: comparison with reference analgesics","volume":"96","author":"Honore","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib112","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1046\/j.1440-1681.2000.03314.x","article-title":"Physiological effects of extracellular nucleotides in the inner ear","volume":"27","author":"Housley","year":"2000","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib113","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1152\/jn.2002.88.4.1614","article-title":"P2X receptors in trigeminal subnucleus caudalis modulate central sensitization in trigeminal subnucleus oralis","volume":"88","author":"Hu","year":"2002","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib114","doi-asserted-by":"crossref","first-page":"4461","DOI":"10.1016\/S0022-5347(18)38937-7","article-title":"Cystometric studies with ATP, PPADS and TNP-ATP in conscious and anaesthetised C57BL\/6 mice","volume":"171","author":"Hu","year":"2004","journal-title":"J Urol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib115","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1124\/jpet.103.052951","article-title":"ATP augments peptide release from rat sensory neurons in culture through activation of P2Y receptors","volume":"306","author":"Huang","year":"2003","journal-title":"J Pharmacol Exp Therap"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib116","unstructured":"Hughes, J. P., Hatcher, J. P., Latcham, J., Marshall, I. C. B., Strijbos, P. J. L., Richardson, J. C., Green, P., Duxon, M. S., & Chessell, I. P. (2004). P2X7 is essential for FCA induced inflammatory pain. Program No. 285.8 2004. Abstract Viewer\/Itinerary Planner. Washington, DC: Society for Neuroscience."},{"key":"10.1016\/j.pharmthera.2005.08.013_bib117","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1439-0264.2004.00540.x","article-title":"Chronological alterations of P2X3 receptor expression in the trigeminal ganglion after ischaemic insult in the Mongolian gerbil","volume":"33","author":"Hwang","year":"2004","journal-title":"Anat Histol Embryol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib118","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.brainres.2004.02.029","article-title":"VR1-, VRL-1- and P2X3 receptor-immunoreactive innervation of the rat temporomandibular joint","volume":"1008","author":"Ichikawa","year":"2004","journal-title":"Brain Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib119","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.lfs.2003.09.006","article-title":"Signaling of ATP receptors in glia-neuron interaction and pain","volume":"74","author":"Inoue","year":"2003","journal-title":"Life Sci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib120","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/ddr.10201","article-title":"ATP induced three types of pain behaviors, including allodynia","volume":"59","author":"Inoue","year":"2003","journal-title":"Drug Dev Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib121","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1254\/jphs.94.112","article-title":"ATP- and adenosine-mediated signaling in the central nervous system: chronic pain and microglia: involvement of the ATP receptor P2X4","volume":"94","author":"Inoue","year":"2004","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib122","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s11302-005-6210-4","article-title":"ATP receptors in pain sensation: involvement of spinal microglia and P2X4 receptors","volume":"1","author":"Inoue","year":"2005","journal-title":"Purinergic Signalling"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib123","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/ddr.1101","article-title":"P2 nucleotide receptors in peripheral nerve trunk","volume":"52","author":"Irnich","year":"2001","journal-title":"Drug Dev Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib124","doi-asserted-by":"crossref","first-page":"C1121","DOI":"10.1152\/ajpcell.00364.2001","article-title":"Nonselective cation conductance activated by muscarinic and purinergic receptors in rat spiral ganglion neurons","volume":"282","author":"Ito","year":"2002","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib125","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0169-328X(99)00339-3","article-title":"Evidence for P2X3, P2X4, P2X5 but not for P2X7 containing purinergic receptors in M\u00fcller cells of the rat retina","volume":"76","author":"Jabs","year":"2000","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib126","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/304730a0","article-title":"ATP excites a subpopulation of rat dorsal horn neurones","volume":"304","author":"Jahr","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib127","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1517\/14728222.7.4.513","article-title":"Contributions of P2X3 homomeric and heteromeric channels to acute and chronic pain","volume":"7","author":"Jarvis","year":"2003","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib128","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/ddr.1119","article-title":"Pharmacological characterisation of P2X3 homomeric and heteromeric channels in nociceptive signaling and behaviour","volume":"52","author":"Jarvis","year":"2001","journal-title":"Drug Dev Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib129","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/sj.bjp.0703793","article-title":"Modulation of BzATP and formalin induced nociception: attenuation by the P2X receptor antagonist, TNP-ATP and enhancement by the P2X3 allosteric modulator, Cibacron blue","volume":"132","author":"Jarvis","year":"2001","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib130","doi-asserted-by":"crossref","first-page":"17179","DOI":"10.1073\/pnas.252537299","article-title":"A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2\/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat","volume":"99","author":"Jarvis","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib131","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1124\/jpet.103.064907","article-title":"[3H]A-317491, a novel high-affinity non-nucleotide antagonist that specifically labels human P2X2\/3 and P2X3 receptors","volume":"310","author":"Jarvis","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib132","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1067\/moe.2002.128973","article-title":"Expression of adenosine triphosphate P2X3 receptors in rat molar pulp and trigeminal ganglia","volume":"94","author":"Jiang","year":"2002","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endo"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib133","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.1523\/JNEUROSCI.0753-04.2004","article-title":"Purinergic and vanilloid receptor activation releases glutamate from separate cranial afferent terminals in nucleus tractus solitarius","volume":"24","author":"Jin","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib134","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/6344","article-title":"Synaptic corelease of ATP and GABA in cultured spinal neurons","volume":"2","author":"Jo","year":"1999","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib135","unstructured":"Kakimoto, S., Tamura, S., Watabiki, T., Nagakura, Y., Shibasaki, K., Wanibuchi, F., & Okada, M. (2004). YM529, a new generation bisphosphonate, exhibits P2X2\/3, 3 receptor antagonism and analgesic effects. Program No. 285.4 2004. Abstract Viewer\/Itinerary Planner. Washington, DC: Society for Neuroscience."},{"key":"10.1016\/j.pharmthera.2005.08.013_bib136","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.neulet.2004.05.069","article-title":"TRPV2-immunoreactive intrinsic neurons in the rat intestine","volume":"366","author":"Kashiba","year":"2004","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib137","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00418-004-0647-3","article-title":"Expression of P2Y1 receptors in rat taste buds","volume":"121","author":"Kataoka","year":"2004","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib138","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0006-8993(02)03200-6","article-title":"ATP selectively suppresses the synthesis of the inflammatory protein microglial response factor (MRF)-1 through Ca2+ influx via P2X7 receptors in cultured microglia","volume":"952","author":"Kaya","year":"2002","journal-title":"Brain Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib139","series-title":"Substances Producing Pain and Itch","first-page":"260","author":"Keele","year":"1964"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib140","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1113\/jphysiol.2003.049114","article-title":"Crossing the pain barrier: P2 receptors as targets for novel analgesics","volume":"553","author":"Kennedy","year":"2003","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib141","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1177\/1073858404274063","article-title":"P2X receptors: targets for novel analgesics?","volume":"11","author":"Kennedy","year":"2005","journal-title":"Neuroscientist"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib142","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/bja\/87.1.3","article-title":"Mechanisms of inflammatory pain","volume":"87","author":"Kidd","year":"2001","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib143","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/sj.bjp.0701286","article-title":"Effects of extracellular pH on agonism and antagonism at a recombinant P2X2 receptor","volume":"121","author":"King","year":"1997","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib144","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/sj.bjp.0705790","article-title":"Investigation of the effects of P2 purinoceptor ligands on the micturition reflex in female urethane-anaesthetised rats","volume":"142","author":"King","year":"2004","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib145","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/sj.bjp.0706187","article-title":"Antagonism of ATP responses at P2X receptor subtypes by the pH indicator dye, Phenol Red","volume":"145","author":"King","year":"2005","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib146","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1469-7793.1999.00551.x","article-title":"Excitatory effect of P2X receptor activation on mesenteric afferent nerves in the anaesthetised rat","volume":"520","author":"Kirkup","year":"1999","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib147","doi-asserted-by":"crossref","first-page":"G787","DOI":"10.1152\/ajpgi.2001.280.5.G787","article-title":"Receptors and transmission in the brain-gut axis: potential for novel therapies. I. Receptors on visceral afferents","volume":"280","author":"Kirkup","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib148","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1139\/y03-111","article-title":"Effects of pentobarbital on purinergic P2X receptors of rat dorsal root ganglion neurons","volume":"81","author":"Kitahara","year":"2003","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib149","doi-asserted-by":"crossref","first-page":"F281","DOI":"10.1152\/ajprenal.00293.2000","article-title":"ATP is released from guinea pig ureter epithelium on distension","volume":"282","author":"Knight","year":"2002","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib150","unstructured":"Koizumi, S., Fujishita, K., Inoue, K., Tsuda, M., & Inoue, K. (2004). Ca2+ waves in keratinocytes are transmitted to sensory neurons; involvement of extracellular ATP and activation of P2Y2 receptors. Program No. 285.13 2004. Abstract Viewer\/Itinerary Planner. Washington, DC: Society for Neuroscience."},{"key":"10.1016\/j.pharmthera.2005.08.013_bib151","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1113\/jphysiol.2003.042028","article-title":"Capsaicin-sensitive and -insensitive vagal bronchopulmonary C-fibres in the mouse","volume":"551","author":"Kollarik","year":"2003","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib152","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1163\/156856902760196342","article-title":"Sympathetic ganglion blockade with phenol in patients with low-back syndromes","volume":"14","author":"Koning","year":"2002","journal-title":"Pain Clin"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib153","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1023\/A:1013532902247","article-title":"Structural and functional characteristics of nociceptive pathways and their alterations under conditions of neuropathy","volume":"33","author":"Kostyuk","year":"2001","journal-title":"Neurophysiology"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib154","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/00042307-200307000-00004","article-title":"Recent developments in the management of detrusor overactivity","volume":"13","author":"Kumar","year":"2003","journal-title":"Curr Opin Urol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib155","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1097\/01.ju.0000131244.67160.f4ABSTRACT","article-title":"Characteristics of adenosine triphosphate release from porcine and human normal bladder","volume":"172","author":"Kumar","year":"2004","journal-title":"J Urol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib156","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1113\/jphysiol.2002.031963","article-title":"Localization and function of ATP and GABAA receptors expressed by nociceptors and other postnatal sensory neurons in rat","volume":"549","author":"Labrakakis","year":"2003","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib157","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0361-9230(01)00433-6","article-title":"Omega-conotoxin GVIA potently inhibits the currents mediated by P2X receptors in rat DRG neurons","volume":"54","author":"Lalo","year":"2001","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib158","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1038\/sj.bjp.0705878","article-title":"Methyllycaconitine, alpha-bungarotoxin and (+)-tubocurarine block fast ATP-gated currents in rat dorsal root ganglion cells","volume":"142","author":"Lalo","year":"2004","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib159","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.2174\/1381612023392973","article-title":"Structure\u2013activity relationships of suramin and pyridoxal-5\u2032-phosphate derivatives as P2 receptor antagonists","volume":"8","author":"Lambrecht","year":"2002","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib160","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1124\/mol.64.4.785","article-title":"Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules","volume":"64","author":"Lazarowski","year":"2003","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib161","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1016\/S0022-5347(05)67618-5","article-title":"Distribution of P2X receptors in the urinary bladder and ureter of the rat","volume":"163","author":"Lee","year":"2000","journal-title":"J Urol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib162","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/ddr.10209","article-title":"Purinergic P2X7 receptor function in lung alveolar macrophages: pharmacologic characterisation and bidirectional regulation by Th1 and Th2 cytokines","volume":"59","author":"Lemaire","year":"2004","journal-title":"Drug Dev Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib163","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/377432a0","article-title":"Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons","volume":"377","author":"Lewis","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib164","doi-asserted-by":"crossref","first-page":"H2636","DOI":"10.1152\/ajpheart.00395.2002","article-title":"ATP stimulates chemically sensitive and sensitizes mechanically sensitive afferents","volume":"283","author":"Li","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib165","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.brainres.2003.09.070","article-title":"Effect of tetramethylpyrazine on acute nociception mediated by signaling of P2X receptor activation in rat","volume":"995","author":"Liang","year":"2004","journal-title":"Brain Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib166","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.brainres.2005.01.076","article-title":"Tetramethylpyrazine inhibits ATP-activated currents in rat dorsal root ganglion neurons","volume":"1040","author":"Liang","year":"2005","journal-title":"Brain Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib167","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0022-3565(24)38849-4","article-title":"Coexpression of P2X3 and P2X2 receptor subunits in varying amounts generates heterogenous populations of P2X receptors that evoke a spectrum of agonist responses comparable to that seen in sensory neurons","volume":"296","author":"Liu","year":"2001","journal-title":"J Pharmacol Exp Therap"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib168","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1097\/00001756-199808030-00022","article-title":"Ultrastructural localization of P2X3 receptors in rat sensory neurons","volume":"9","author":"Llewellyn-Smith","year":"1998","journal-title":"NeuroReport"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib169","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/1529-0131(199802)41:2<246::AID-ART8>3.0.CO;2-I","article-title":"ATP and UTP activate calcium-mobilizing P2U-like receptors and act synergistically with interleukin-1 to stimulate prostaglandin E2 release from human rheumatoid synovial cells","volume":"41","author":"Loredo","year":"1998","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib170","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00441-004-0939-x","article-title":"Expression of P2 receptors at sites of chronic inflammation","volume":"317","author":"Luttikhuizen","year":"2004","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib171","unstructured":"Malin, S. A., Molliver, D. C., Reynolds, I. J., & Davis, B. M. (2004). Nucleotide receptor activity in sensory neurons: role of P2Y2. Program No. 285.11 2004. Abstract Viewer\/Itinerary Planner. Washington, DC: Society for Neuroscience."},{"key":"10.1016\/j.pharmthera.2005.08.013_bib172","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0009-8981(87)90337-8","article-title":"Human tumour tissues have higher ATP content than normal tissues","volume":"169","author":"Maehara","year":"1987","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib173","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrc747","article-title":"Molecular mechanisms of cancer pain","volume":"2","author":"Mantyh","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib174","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/00000539-200101000-00026","article-title":"The anesthetic interaction between adenosine triphosphate and N-methyl-d-aspartate receptor antagonists in the rat","volume":"92","author":"Masaki","year":"2001","journal-title":"Anaesth Analg"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib175","unstructured":"Matsuka, Y., Ono, T., Iwase, H., Omoto, K. S., Mitrirattanakul, S., & Spigelman, I. (2004). Peripheral neuropathy alters ATP release from sensory ganglia. Program No. 285.1 2004. Abstract Viewer\/Itinerary Planner. Washington, DC: Society for Neuroscience."},{"key":"10.1016\/j.pharmthera.2005.08.013_bib176","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0014-2999(01)01568-0","article-title":"Potent desensitization of human P2X3 receptors by diadenosine polyphosphates","volume":"435","author":"McDonald","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib177","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/00001756-200203250-00015","article-title":"HSP90 inhibitors alter capsaicin- and ATP-induced currents in rat dorsal root ganglion neurons","volume":"13","author":"McDowell","year":"2002","journal-title":"NeuroReport"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib178","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1038\/sj.bjp.0705574","article-title":"Effects of A-317491, a novel and selective P2X3\/P2X2\/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration","volume":"140","author":"McGaraughty","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib179","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/j.1469-7793.1998.843bs.x","article-title":"Activation of P2X receptors for adenosine triphosphate evokes cardiorespiratory reflexes in anaesthetized rats","volume":"507","author":"McQueen","year":"1998","journal-title":"J Physiol (London)"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib180","first-page":"567","article-title":"ATP in the mechanotransduction pathway of normal human chondrocytes","volume":"41","author":"Millward-Sadler","year":"2004","journal-title":"Biorheology"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib181","doi-asserted-by":"crossref","first-page":"7174","DOI":"10.1073\/pnas.95.12.7174","article-title":"A release mechanism for stored ATP in ocular ciliary epithelial cells","volume":"95","author":"Mitchell","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib182","doi-asserted-by":"crossref","first-page":"6992","DOI":"10.1523\/JNEUROSCI.14-11-06992.1994","article-title":"Fluorescence imaging of extracellular purinergic receptor sites and putative ecto-ATPase sites on isolated cochlear hair cells","volume":"14","author":"Mockett","year":"1994","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib183","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1046\/j.1460-9568.2002.02253.x","article-title":"ATP and UTP excite sensory neurons and induce CREB phosphorylation through the metabotropic receptor, P2Y2","volume":"16","author":"Molliver","year":"2002","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib184","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1124\/jpet.102.034991","article-title":"Emerging pharmacologic approaches for the treatment of lower urinary tract disorders","volume":"308","author":"Moreland","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib185","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.pain.2004.07.016","article-title":"Development of tactile allodynia and thermal hyperalgesia by intrathecally administered platelet-activating factor in mice","volume":"111","author":"Morita","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib186","doi-asserted-by":"crossref","first-page":"6058","DOI":"10.1523\/JNEUROSCI.23-14-06058.2003","article-title":"Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity","volume":"23","author":"Moriyama","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib187","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1090-3801(02)00096-4","article-title":"Experimental muscle pain and tenderness following infusion of endogenous substances in humans","volume":"7","author":"M\u00f8rk","year":"2003","journal-title":"Eur J Pain"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib188","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1080\/000164801300006209","article-title":"Vesicular storage of adenosine triphosphate in the guinea-pig cochlear lateral wall and concentrations of ATP in the endolymph during sound exposure and hypoxia","volume":"121","author":"Munoz","year":"2001","journal-title":"Acta Oto-laryngol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib189","unstructured":"Nagamine, K., Ozaki, N., Shinoda, M., Asai, H., Kuba, K., Tohnai, I., Ueda, M., & Sugiura, Y. (2004). Thermal and mechanical hyperalgesia induced by experimental squamous cell carcinoma of the lower gingival in rats. Program No. 298.9 2004. Abstract Viewer\/Itinerary Planner. Washington, DC: Society for Neuroscience."},{"key":"10.1016\/j.pharmthera.2005.08.013_bib190","doi-asserted-by":"crossref","first-page":"10465","DOI":"10.1073\/pnas.93.19.10465","article-title":"P2Y1 purinergic receptors in sensory neurons: contribution to touch-induced impulse generation","volume":"93","author":"Nakamura","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib191","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1523\/JNEUROSCI.22-04-01228.2002","article-title":"Activation of central terminal vanilloid receptor-1 receptors and alpha beta-methylene-ATP-sensitive P2X receptors reveals a converged synaptic activity onto the deep dorsal horn neurons of the spinal cord","volume":"22","author":"Nakatsuka","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib192","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1113\/jphysiol.1991.sp018491","article-title":"Comparison of adenosine triphosphate- and nicotine-activated inward currents in rat phaeochromocytoma cells","volume":"434","author":"Nakazawa","year":"1991","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib193","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1096\/fj.04-1933fje","article-title":"P2Y-mediated Ca2+ response is spatiotemporally graded and synchronized in sensory neurons: a two-photon photolysis study","volume":"18","author":"Nakayama","year":"2004","journal-title":"FASEB J"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib194","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1046\/j.1464-410x.1999.00310.x","article-title":"Purinergic sensory neurotransmission in the urinary bladder: an in vitro study in the rat","volume":"84","author":"Namasivayam","year":"1999","journal-title":"Br J Urol Int"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib195","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/sj.bjp.0705411","article-title":"2\u2032, 3\u2032-O-(2,4,6,trinitrophenyl)-ATP and A-317491 are competitive antagonists at a slowly desensitizing chimeric human P2X3 receptor","volume":"140","author":"Neelands","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib196","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0079-6123(01)32080-0","article-title":"Calcium signaling in retinal glial cells and its effect on neuronal activity","volume":"132","author":"Newman","year":"2001","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib197","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/j.1460-9568.2004.03508.x","article-title":"Effects of isolectin B4-conjugated saporin, a targeting cytotoxin, on bladder overactivity induced by bladder irritation","volume":"20","author":"Nishiguchi","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib198","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1113\/jphysiol.2003.048587","article-title":"P2X3 receptors and peripheral pain mechanisms","volume":"554","author":"North","year":"2004","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib199","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1124\/jpet.102.036079","article-title":"Analgesic effects of intrathecal administration of P2Y nucleotide receptor agonists UTP and UDP in normal and neuropathic pain model rats","volume":"303","author":"Okada","year":"2002","journal-title":"J Pharmacol Exp Therap"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib200","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ejpain.2004.04.006","article-title":"Evidence for the involvement of endogenous ATP and P2X receptors in TMJ pain","volume":"9","author":"Oliveira","year":"2005","journal-title":"Eur J Pain"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib201","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1056\/NEJMra032662","article-title":"Management of overactive bladder","volume":"350","author":"Ouslander","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib202","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1469-7793.2000.00403.x","article-title":"P2X purinoceptor-induced sensitization of ferret vagal mechanoreceptors in oesophageal inflammation","volume":"523","author":"Page","year":"2000","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib203","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1152\/jn.00785.2001","article-title":"Vagal mechanoreceptors and chemoreceptors in mouse stomach and esophagus","volume":"87","author":"Page","year":"2002","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib302","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1016\/S0022-5347(17)35955-4","article-title":"Evidence for purinergic neurotransmission in human urinary bladder affected by interstitial cystitis","volume":"150","author":"Palea","year":"1993","journal-title":"J Urol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib204","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/S0022-5347(05)64631-9","article-title":"Intravesical adenosine triphosphate stimulates the micturition reflex in awake, freely moving rats","volume":"168","author":"Pandita","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib205","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0304-3959(00)00277-3","article-title":"Effects of purinergic and adrenergic antagonists in a rat model of painful peripheral neuropathy","volume":"87","author":"Park","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib206","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.brainres.2004.01.061","article-title":"Modulation of sodium currents in rat sensory neurons by nucleotides","volume":"1006","author":"Park","year":"2004","journal-title":"Brain Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib303","doi-asserted-by":"crossref","first-page":"21077","DOI":"10.1074\/jbc.M101465200","article-title":"Inflammatory mediators potentiate ATP-gated channels through the P2X3 subunit","volume":"276","author":"Paukert","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib207","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1113\/jphysiol.2001.012836","article-title":"Expression of P2X2 and P2X3 receptor subunits in rat carotid body afferent neurones: role in chemosensory signalling","volume":"537","author":"Prasad","year":"2001","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib208","doi-asserted-by":"crossref","first-page":"6537","DOI":"10.1073\/pnas.121190798","article-title":"Interaction between vanilloid receptors and purinergic metabotropic receptors: pain perception and beyond","volume":"98","author":"Premkumar","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib209","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0031-6997(24)01373-5","article-title":"Receptors for purines and pyrimidines","volume":"50","author":"Ralevic","year":"1998","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib210","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0304-3940(02)01360-5","article-title":"Adenosine triphosphate as a stimulant for nociceptive and non-nociceptive muscle group IV receptors in the rat","volume":"338","author":"Rein\u00f6hl","year":"2003","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib211","first-page":"245","article-title":"Capsaicin receptor VR1 and ATP purinoceptor P2X3 in painful and nonpainful human tooth pulp","volume":"17","author":"Renton","year":"2003","journal-title":"J Orofac Pain"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib212","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/01.TA.0000078882.11919.AF","article-title":"Adenosine triphosphate is released during injurious mechanical ventilation and contributes to lung edema","volume":"55","author":"Rich","year":"2003","journal-title":"J Trauma"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib213","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1046\/j.1365-2982.2003.00456.x","article-title":"Characterization of the primary spinal afferent innervation of the mouse colon using retrograde labelling","volume":"16","author":"Robinson","year":"2004","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib214","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.neuropharm.2004.08.003","article-title":"Activation of ureter nociceptors by exogenous and endogenous ATP in guinea pig","volume":"47","author":"Rong","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib215","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/j.1469-7793.2000.00891.x","article-title":"P2X purinoceptor-mediated excitation of trigeminal lingual nerve terminals in an in vitro intra-arterially perfused rat tongue preparation","volume":"524","author":"Rong","year":"2000","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib216","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1113\/jphysiol.2001.013469","article-title":"Activation and sensitisation of low and high threshold afferent fibres mediated by P2X receptors in the mouse urinary bladder","volume":"541","author":"Rong","year":"2002","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib217","doi-asserted-by":"crossref","first-page":"11315","DOI":"10.1523\/JNEUROSCI.23-36-11315.2003","article-title":"Pivotal role of nucleotide P2X2 receptor subunit mediating ventilatory responses to hypoxia: knockout mouse studies","volume":"23","author":"Rong","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib218","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00418-003-0579-3","article-title":"Localisation of P2Y1 and P2Y4 receptors in dorsal root, nodose and trigeminal ganglia of the rat","volume":"120","author":"Ruan","year":"2003","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib219","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/nrd1107","article-title":"Neurotrophic factors as novel therapeutics for neuropathic pain","volume":"2","author":"Sah","year":"2003","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib220","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0306-4522(03)00463-9","article-title":"Effects of extracellular ATP on axonal transport in cultured mouse dorsal root ganglion neurons","volume":"121","author":"Sakama","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib221","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/0306-4522(85)90080-6","article-title":"Effects of adenosine 5\u2032-monophosphate and adenosine 5\u2032-triphosphate on functionally identified units in the cat spinal dorsal horn. Evidence for a differential effect of adenosine 5\u2032-triphosphate on nociceptive vs non-nociceptive units","volume":"15","author":"Salter","year":"1985","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib222","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0306-4522(02)00005-2","article-title":"Increase in intracellular Ca2+ and calcitonin gene-related peptide release through metabotropic P2Y receptors in rat dorsal root ganglion neurons","volume":"111","author":"Sanada","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib223","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0301-0082(03)00050-9","article-title":"Adenosine in the spinal cord and periphery: release and regulation of pain","volume":"69","author":"Sawynok","year":"2003","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib224","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0079-6123(00)29013-4","article-title":"The role of high-threshold calcium channels in spinal neuron hyperexcitability induced by knee inflammation","volume":"129","author":"Schaible","year":"2000","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib225","first-page":"31","article-title":"Cellular mechanisms and physiology of nucleotide and nucleoside release from cells: current knowledge, novel assays to detect purinergic agonists, and future directions","volume":"vol. 54","author":"Schwiebert","year":"2003"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib226","unstructured":"Selden, N. R., Siler, L. N., Close, L. N., & Heinricher, M. M. (2004). Purinergic control of medullary pain-modulating neurons. Program No. 296.2 2004. Abstract Viewer\/Itinerary Planner. Washington, DC: Society for Neuroscience."},{"key":"10.1016\/j.pharmthera.2005.08.013_bib227","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1136\/jnnp.70.3.410","article-title":"Neuropathic pain with vesical and rectal hyperreflexia and cocontraction after pelvic surgery","volume":"70","author":"Shembalkar","year":"2001","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib228","doi-asserted-by":"crossref","first-page":"23559","DOI":"10.1074\/jbc.M314240200","article-title":"Identification of a G protein-coupled receptor specifically responsive to beta-alanine","volume":"279","author":"Shinohara","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib229","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0022-5347(18)37626-2","article-title":"Botulinum toxin A inhibits mechanoreceptor-mediated urothelial release of ATP in conditions of bladder inflammation","volume":"171","author":"Smith","year":"2004","journal-title":"J Urol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib230","doi-asserted-by":"crossref","first-page":"4958","DOI":"10.1523\/JNEUROSCI.21-14-04958.2001","article-title":"Negative cross talk between anionic GABAA and cationic P2X ionotropic receptors of rat dorsal root ganglion neurons","volume":"21","author":"Sokolova","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib231","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0304-3940(02)01369-1","article-title":"The ATP-mediated fast current of rat dorsal root ganglion neurons is a novel effector for GABA(B) receptor activation","volume":"338","author":"Sokolova","year":"2003","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib232","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0304-3940(03)00082-X","article-title":"Spinal adenosine agonist reduces c-fos and astrocyte activation in dorsal horn of rats with adjuvant-induced arthritis","volume":"340","author":"Sorkin","year":"2003","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib233","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1111\/j.0953-816X.2004.03329.x","article-title":"Subunit-specific P2X-receptor expression defines chemosensory properties of trigeminal neurons","volume":"19","author":"Spehr","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib234","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1038\/sj.bjp.0704591","article-title":"Kinetics of antagonist actions at rat P2X2\/3 heteromeric receptors","volume":"135","author":"Spelta","year":"2002","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib235","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1152\/jappl.1993.74.6.3052","article-title":"Differential modulation by extracellular ATP of carotid chemosensory responses","volume":"74","author":"Spergel","year":"1993","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib236","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/S0169-409X(03)00105-4","article-title":"The pain of antisense: in vivo application of antisense oligonucleotides for functional genomics in pain and analgesia","volume":"55","author":"Stone","year":"2003","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib237","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.pain.2004.01.007","article-title":"The P2Y agonist UTP activates cutaneous afferent fibers","volume":"109","author":"Stucky","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib238","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1097\/01.ju.0000108120.28291.eb","article-title":"Electrical characteristics of suburothelial cells isolated from the human bladder","volume":"171","author":"Sui","year":"2004","journal-title":"J Urol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib239","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1046\/j.1464-410X.2002.02912.x","article-title":"Effects of dimethyl sulphoxide and heparin on stretch-activated ATP release by bladder urothelial cells from patients with interstitial cystitis","volume":"90","author":"Sun","year":"2002","journal-title":"BJU Int"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib240","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1097\/01.ju.0000099660.46774.3c","article-title":"Up-regulation of P2X3 receptor during stretch of bladder urothelial cells from patients with interstitial cystitis","volume":"171","author":"Sun","year":"2004","journal-title":"J Urol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib241","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1523\/JNEUROSCI.3792-03.2004","article-title":"Production and release of neuroprotective tumor necrosis factor by P2X7 receptor-activated microglia","volume":"24","author":"Suzuki","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib242","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1097\/00001756-199705060-00002","article-title":"ATP induces Ca2+ release from IP3-sensitive Ca2+ stores exclusively in large DRG neurones","volume":"8","author":"Svichar","year":"1997","journal-title":"NeuroReport"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib243","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1046\/j.1460-9568.2003.02681.x","article-title":"Expression of oncostatin M receptor beta in a specific subset of nociceptive sensory neurons","volume":"17","author":"Tamura","year":"2003","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib244","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1111\/j.1464-410X.2004.04858.x","article-title":"P2X and P2X receptor expression in human bladder urothelium and changes in interstitial cystitis","volume":"93","author":"Tempest","year":"2004","journal-title":"BJU Int"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib245","doi-asserted-by":"crossref","first-page":"6951","DOI":"10.1073\/pnas.111025298","article-title":"Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia","volume":"98","author":"Tominaga","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib246","doi-asserted-by":"crossref","first-page":"RC90","DOI":"10.1523\/JNEUROSCI.20-15-j0007.2000","article-title":"Mechanical allodynia caused by intraplantar injection of P2X receptor agonist in rats: involvement of heteromeric P2X2\/3 receptor signaling in capsaicin-insensitive primary afferent neurons","volume":"20","author":"Tsuda","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib247","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1097\/00001756-200106130-00036","article-title":"Role of endogenous ATP at the incision area in a rat model of postoperative pain","volume":"12","author":"Tsuda","year":"2001","journal-title":"NeuroReport"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib248","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nature01786","article-title":"P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury","volume":"424","author":"Tsuda","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib249","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.tins.2004.12.002","article-title":"Neuropathic pain and spinal microglia: a big problem from molecules in \u2018small\u2019 glia","volume":"28","author":"Tsuda","year":"2005","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib250","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0304-3959(00)00456-5","article-title":"Differential regulation of P2X3 mRNA expression by peripheral nerve injury in intact and injured neurons in the rat sensory ganglia","volume":"91","author":"Tsuzuki","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib251","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1152\/jn.01171.2002","article-title":"TNP-ATP-resistant P2X ionic current on the central terminals and somata of rat primary sensory neurons","volume":"89","author":"Tsuzuki","year":"2003","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib252","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1358\/dnp.2003.16.9.829343","article-title":"Molecular mechanism of neuropathic pain","volume":"16","author":"Ueda","year":"2003","journal-title":"Drug News Perspect"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib253","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/sj.bjp.0702319","article-title":"Cell type-specific ATP-activated responses in rat dorsal root ganglion neurons","volume":"126","author":"Ueno","year":"1999","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib254","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/ddr.10208","article-title":"Involvement of P2X2 and P2X3 receptors in neuropathic pain in a mouse model of chronic constriction injury","volume":"59","author":"Ueno","year":"2003","journal-title":"Drug Dev Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib255","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1113\/jphysiol.2003.060079","article-title":"Subtypes of vagal afferent C-fibres in guinea-pig lungs","volume":"556","author":"Undem","year":"2004","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib256","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0896-6273(01)00557-8","article-title":"Bradykinin and ATP accelerate Ca2+ efflux from rat sensory neurons via protein kinase C and the plasma membrane Ca2+ pump isoform 4","volume":"33","author":"Usachev","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib257","first-page":"969","article-title":"Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3, and heteromeric P2X2\/3 receptors","volume":"53","author":"Virginio","year":"1998","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib258","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1523\/JNEUROSCI.21-15-05670.2001","article-title":"P2X3 knockout mice reveal a major sensory role for urothelially released ATP","volume":"21","author":"Vlaskovska","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib259","doi-asserted-by":"crossref","first-page":"8063","DOI":"10.1073\/pnas.93.15.8063","article-title":"Differential distribution of two ATP-gated channels (P2X receptors) determined by imunocytochemistry","volume":"93","author":"Vulchanova","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib260","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0306-4522(01)00377-3","article-title":"Cytotoxic targeting of isolectin IB4-binding sensory neurons","volume":"108","author":"Vulchanova","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib261","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.pain.2004.03.012","article-title":"Peripheral P2X receptors and nociception: interactions with biogenic amine systems","volume":"110","author":"Waldron","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib262","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/0049-0172(89)90050-4","article-title":"The use of quinacrine (Atabrine) in rheumatic diseases: a reexamination","volume":"18","author":"Wallace","year":"1989","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib263","unstructured":"Wang, C., & Huang, L. M. (2004). Prostaglandin E2 potentiates P2X3-receptor mediated-responses in dorsal root ganglion neurons. Program No. 285.5 2004. Abstract Viewer\/Itinerary Planner. Washington, DC: Society for Neuroscience."},{"key":"10.1016\/j.pharmthera.2005.08.013_bib264","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0006-8993(01)03211-5","article-title":"Neurokinin B potentiates ATP-activated currents in rat DRG neurons","volume":"923","author":"Wang","year":"2001","journal-title":"Brain Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib265","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0306-4522(03)00491-3","article-title":"Glial cell line-derived neurotrophic factor normalizes neurochemical changes in injured dorsal root ganglion neurons and prevents the expression of experimental neuropathic pain","volume":"121","author":"Wang","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib266","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1152\/physrev.00011.2002","article-title":"Beyond neurons: evidence that immune and glial cells contribute to pathological pain states","volume":"82","author":"Watkins","year":"2002","journal-title":"Physiol Rev"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib267","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S0306-4522(03)00388-9","article-title":"P2 receptors in satellite glial cells in trigeminal ganglia of mice","volume":"120","author":"Weick","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib268","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0169-328X(00)00020-6","article-title":"Expression of purinergic receptors in bipolar cells of the rat retina","volume":"76","author":"Wheeler-Schilling","year":"2000","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib269","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0169-328X(01)00160-7","article-title":"Identification of purinergic receptors in retinal ganglion cells","volume":"92","author":"Wheeler-Schilling","year":"2001","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib270","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0006-8993(02)04193-8","article-title":"Distinct neurochemical mechanisms are activated following administration of different P2X receptor agonists into the hindpaw of a rat","volume":"965","author":"Wismer","year":"2003","journal-title":"Brain Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib271","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1073\/pnas.0306707101","article-title":"P2X7 receptors control 2-arachidonoylglycerol production by microglial cells","volume":"101","author":"Witting","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib272","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1113\/jphysiol.2004.067934","article-title":"Purinergic regulation of guinea pig suburothelial myofibroblasts","volume":"559","author":"Wu","year":"2004","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib273","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jpain.2003.09.006","article-title":"Suramin inhibits spinal cord microglia activation and long-term hyperalgesia induced by formalin injection","volume":"5","author":"Wu","year":"2004","journal-title":"J Pain"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib274","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejphar.2004.09.056","article-title":"A-317491, a selective P2X3\/P2X2\/3 receptor antagonist, reverses inflammatory mechanical hyperalgesia through action on peripheral receptors in rats","volume":"504","author":"Wu","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib275","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1046\/j.1442-2042.10.s1.11.x","article-title":"The basics behind bladder pain: a review of data on lower urinary tract sensations","volume":"10","author":"Wyndaele","year":"2003","journal-title":"Int J Urol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib276","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.gastro.2003.07.008","article-title":"Purinergic mechanisms contribute to mechanosensory transduction in the rat colorectum","volume":"125","author":"Wynn","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib277","doi-asserted-by":"crossref","first-page":"G647","DOI":"10.1152\/ajpgi.00020.2004","article-title":"Purinergic component of mechanosensory transduction is increased in a rat model of colitis","volume":"287","author":"Wynn","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib278","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00418-004-0620-1","article-title":"P2X2 and P2X3 purinoceptors in the rat enteric nervous system","volume":"121","author":"Xiang","year":"2004","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib279","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00418-004-0680-2","article-title":"Development of nerves expressing P2X3 receptors in the myenteric plexus of rat stomach","volume":"122","author":"Xiang","year":"2004","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib280","doi-asserted-by":"crossref","first-page":"8360","DOI":"10.1073\/pnas.122231899","article-title":"Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain","volume":"99","author":"Xiao","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib281","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0006-8993(03)02342-4","article-title":"Cross-inhibition of mechanoreceptive inputs in dorsal root ganglia of peripheral inflammatory cats","volume":"970","author":"Xu","year":"2003","journal-title":"Brain Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib282","doi-asserted-by":"crossref","first-page":"11868","DOI":"10.1073\/pnas.0401490101","article-title":"Ca2+\/calmodulin-dependent protein kinase II potentiates ATP responses by promoting trafficking of P2X receptors","volume":"101","author":"Xu","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib283","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/S0028-3908(02)00127-2","article-title":"Modulation by oxytocin of ATP-activated currents in rat dorsal root ganglion neurons","volume":"43","author":"Yang","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib284","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1097\/00001756-200004070-00019","article-title":"P2X3 receptor in injured human sensory neurons","volume":"11","author":"Yiangou","year":"2000","journal-title":"NeuroReport"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib285","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1046\/j.1365-2982.2001.00276.x","article-title":"ATP-gated ion channel P2X3 is increased in human inflammatory bowel disease","volume":"13","author":"Yiangou","year":"2001","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib286","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.urology.2003.11.003","article-title":"Management of detrusor dysfunction in the elderly: changes in acetylcholine and adenosine triphosphate release during aging","volume":"63","author":"Yoshida","year":"2004","journal-title":"Urology"},{"issue":"181","key":"10.1016\/j.pharmthera.2005.08.013_bib287","first-page":"47","article-title":"Purinergic agonists sensitize pelvic afferent nerves in the vitro urinary bladder-pelvic nerve preparation of the rat","volume":"169","author":"Yu","year":"2004","journal-title":"J Urol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib288","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1113\/jphysiol.2004.079574","article-title":"Vagal afferent nerves with nociceptive properties in guinea-pig oesophagus","volume":"563","author":"Yu","year":"2005","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib289","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1113\/jphysiol.2003.051862","article-title":"Mechanotransduction by intraganglionic laminar endings of vagal tension receptors in the guinea-pig oesophagus","volume":"553","author":"Zagorodnyuk","year":"2003","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib290","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neuroscience.2004.03.019","article-title":"Purinergic synapses formed between rat sensory neurons in primary culture","volume":"126","author":"Zarei","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib291","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1469-7793.2000.t01-1-00143.x","article-title":"Co-release of ATP and ACh mediates hypoxic signalling at rat carotid body chemoreceptors","volume":"525","author":"Zhang","year":"2000","journal-title":"J Physiol (London)"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib292","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0361-9230(00)00422-6","article-title":"Alteration of spontaneous firing rate of primary myelinated afferents by ATP in adjuvant-induced inflamed rats","volume":"54","author":"Zhang","year":"2001","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib293","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00210-003-0748-x","article-title":"Effects of resiniferatoxin desensitization of capsaicin-sensitive afferents on detrusor over-activity induced by intravesical capsaicin, acetic acid or ATP in conscious rats","volume":"367","author":"Zhang","year":"2003","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib294","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0306-4522(03)00243-4","article-title":"Bladder and cutaneous sensory neurons of the rat express different functional P2X receptors","volume":"120","author":"Zhong","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib295","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0006-8993(01)02845-1","article-title":"Development of purinergic sensitivity in sensory neurons after peripheral nerve injury in the rat","volume":"915","author":"Zhou","year":"2001","journal-title":"Brain Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib296","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0006-8993(01)02512-4","article-title":"A-134974: a novel adenosine kinase inhibitor, relieves tactile allodynia via spinal sites of action in peripheral nerve injured rats","volume":"905","author":"Zhu","year":"2001","journal-title":"Brain Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib297","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/ddr.1097","article-title":"Ectonucleotidases: some recent developments and a note on nomenclature","volume":"52","author":"Zimmermann","year":"2001","journal-title":"Drug Dev Res"},{"key":"10.1016\/j.pharmthera.2005.08.013_bib298","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0304-3959(02)00027-1","article-title":"ATP can enhance the proton-induced CGRP release through P2Y receptors and secondary PGE2 release in isolated rat dura mater","volume":"97","author":"Zimmermann","year":"2002","journal-title":"Pain"}],"container-title":["Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725805001993?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725805001993?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T23:06:54Z","timestamp":1736032014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725805001993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":303,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["S0163725805001993"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2005.08.013","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2006,6]]}}}