{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:34:56Z","timestamp":1790872496646,"version":"4.1.0"},"reference-count":199,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1016\/j.pharmthera.2005.10.008","type":"journal-article","created":{"date-parts":[[2005,12,16]],"date-time":"2005-12-16T07:13:23Z","timestamp":1134717203000},"page":"384-399","source":"Crossref","is-referenced-by-count":77,"title":["Vascular endothelial dysfunction in diabetic cardiomyopathy: Pathogenesis and potential treatment targets"],"prefix":"10.1016","volume":"111","author":[{"given":"Hana","family":"Farhangkhoee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zia A.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harkiran","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiping","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shali","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subrata","family":"Chakrabarti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharmthera.2005.10.008_bib1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/sj.eye.6700642","article-title":"Inducible nitric oxide synthase and vascular endothelial growth factor are colocalized in the retinas of human subjects with diabetes","volume":"18","author":"Abu El-Asrar","year":"2004","journal-title":"Eye"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib2","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1093\/cvr\/27.6.942","article-title":"Diminished arterial elasticity in diabetes: association with fluorescent advanced glycosylation end products in collagen","volume":"27","author":"Airaksinen","year":"1993","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib3","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S1056-8727(01)00137-4","article-title":"The relation between plasma endothelin-1 levels and metabolic control, risk factors, treatment modalities, and diabetic microangiopathy in patients with type 2 diabetes mellitus","volume":"15","author":"Ak","year":"2001","journal-title":"J Diabetes Its Complicat"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0300-8932(98)74709-8","article-title":"Anatomopathological bases of latent ventricular dysfunction in insulin-dependent diabetics","volume":"51","author":"Anguera","year":"1998","journal-title":"Rev Esp Cardiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/00004872-200301000-00002","article-title":"Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes","volume":"21","author":"Aronson","year":"2003","journal-title":"J Hypertens"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib6","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1007\/s00125-004-1582-5","article-title":"High-dose thiamine therapy counters dyslipidaemia in streptozotocin-induced diabetic rats","volume":"47","author":"Babaei-Jadidi","year":"2004","journal-title":"Diabetologia"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib7","doi-asserted-by":"crossref","first-page":"880","DOI":"10.7326\/0003-4819-132-11-200006060-00005","article-title":"Lower-extremity edema associated with gene transfer of naked DNA encoding vascular endothelial growth factor","volume":"132","author":"Baumgartner","year":"2000","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2337\/diabetes.48.1.1","article-title":"Role of oxidative stress in diabetic complications: a new perspective on an old paradigm","volume":"48","author":"Baynes","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib9","doi-asserted-by":"crossref","first-page":"708","DOI":"10.2337\/diacare.18.5.708","article-title":"Diabetic cardiomyopathy. A unique entity or a complication of coronary artery disease?","volume":"18","author":"Bell","year":"1995","journal-title":"Diabetes Care"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib10","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.2337\/diacare.27.7.1660","article-title":"The effect of pioglitazone on peroxisome proliferator-activated receptor-gamma target genes related to lipid storage in vivo","volume":"27","author":"Bogacka","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib11","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/414813a","article-title":"Biochemistry and molecular cell biology of diabetic complications","volume":"414","author":"Brownlee","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib12","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1126\/science.3487117","article-title":"Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking","volume":"232","author":"Brownlee","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib13","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1056\/NEJM198805193182007","article-title":"Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications","volume":"318","author":"Brownlee","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1152\/physrev.00017.2002","article-title":"Cardiac endothelial-myocardial signaling: its role in cardiac growth, contractile performance, and rhythmicity","volume":"83","author":"Brutsaert","year":"2003","journal-title":"Physiol Rev"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib15","first-page":"F983","article-title":"Molecular basis of osmotic regulation","volume":"268","author":"Burg","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib16","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1385\/CT:1:3:181","article-title":"Oxidative stress and diabetic cardiomyopathy: a brief review","volume":"1","author":"Cai","year":"2001","journal-title":"Cardiovasc Toxicol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib17","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1161\/01.RES.0000065620.39919.20","article-title":"A breaker of advanced glycation end products attenuates diabetes-induced myocardial structural changes","volume":"18","author":"Candido","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0188-4409(03)00004-3","article-title":"Heart metabolic disturbances in cardiovascular diseases","volume":"34","author":"Carvajal","year":"2003","journal-title":"Arch Med Res"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0168-8227(92)90130-J","article-title":"The effect of myo-inositol treatment on basement membrane thickening in the BB\/W-rat retina","volume":"16","author":"Chakrabarti","year":"1992","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib20","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.2337\/diabetes.51.10.3095","article-title":"Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes","volume":"51","author":"Chandra","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib21","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1006\/jmcc.2000.1197","article-title":"Diabetes-induced myocardial structural changes: role of endothelin-1 and its receptors","volume":"32","author":"Chen","year":"2000","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib22","first-page":"E1089","article-title":"Differential activation of NF-kappa B and AP-1 in increased fibronectin synthesis in target organs of diabetic complications","volume":"284","author":"Chen","year":"2003","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib23","doi-asserted-by":"crossref","first-page":"C263","DOI":"10.1152\/ajpcell.00192.2002","article-title":"High glucose-induced, endothelin-dependent fibronectin synthesis is mediated via NF-kappa B and AP-1","volume":"284","author":"Chen","year":"2003","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib24","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1080\/10715760400017228","article-title":"Pro-oxidant role of heme oxygenase in mediating glucose-induced endothelial cell damage","volume":"38","author":"Chen","year":"2004","journal-title":"Free Radic Res"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib25","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1161\/hc0302.102143","article-title":"Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired collateral formation in cardiac tissue","volume":"105","author":"Chou","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib26","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.2337\/diacare.15.8.1038","article-title":"Plasma endothelin-like immunoreactivity levels in IDDM patients with microalbuminuria","volume":"15","author":"Collier","year":"1992","journal-title":"Diabetes Care"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib27","doi-asserted-by":"crossref","first-page":"72","DOI":"10.2337\/diacare.16.2.72","article-title":"Role of cardiovascular risk factors in prevention and treatment of macrovascular disease in diabetes","volume":"16","author":"Consensus statement","year":"1993","journal-title":"Diabetes Care"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib28","doi-asserted-by":"crossref","first-page":"31S","DOI":"10.1016\/j.amjhyper.2004.08.021","article-title":"Importance of advanced glycation end products in diabetes-associated cardiovascular and renal disease","volume":"17","author":"Cooper","year":"2004","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib29","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1161\/01.CIR.91.1.139","article-title":"Tetrahydrobiopterin and dysfunction of endothelial nitric oxide synthase in coronary arteries","volume":"91","author":"Cosentino","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib30","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S1262-3636(07)70059-9","article-title":"Left ventricular diastolic dysfunction: an early sign of diabetic cardiomyopathy?","volume":"29","author":"Cosson","year":"2003","journal-title":"Diabetes Metab"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib31","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1076\/ceyr.27.5.301.17227","article-title":"Heme oxygenase in the retina in diabetes","volume":"27","author":"Cukiernik","year":"2003","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib32","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s001250051644","article-title":"High glucose induces ventricular instability and increases vasomotor tone in rats","volume":"44","author":"D'Amico","year":"2001","journal-title":"Diabetologia"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib33","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.ahj.2004.04.019","article-title":"Effects of diabetes mellitus and ischemic heart disease on the progression from asymptomatic left ventricular dysfunction to symptomatic heart failure: a retrospective analysis from the Studies of Left Ventricular Dysfunction (SOLVD) Prevention trial","volume":"148","author":"Das","year":"2004","journal-title":"Am Heart J"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib34","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2174\/1389201023378265","article-title":"Modulating poly (ADP-ribose) polymerase activity: potential for the prevention and therapy of pathogenic situations involving DNA damage and oxidative stress","volume":"3","author":"Decker","year":"2002","journal-title":"Curr Pharm Biotechnol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib35","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1210\/jc.85.2.793","article-title":"Plasma free fatty acids and endothelium-dependent vasodilation: effect of chain-length and cyclooxygenase inhibition","volume":"85","author":"de Kreutzenberg","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib36","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.2174\/0929867033457359","article-title":"Polymorphisms of the aldose reductase gene and susceptibility to diabetic microvascular complications","volume":"10","author":"Demaine","year":"2003","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib37","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1056\/NEJM199309303291401","article-title":"The effect of intensive treatment of diabetes on the development of long-term complications in insulin-dependent diabetes mellitus","volume":"329","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib38","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1007\/s001250051676","article-title":"15th Golgi lecture: from hyperglycaemia to the dysregulation of vascular remodelling in diabetes","volume":"44","author":"Di Mario","year":"2001","journal-title":"Diabetologia"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib39","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s001250051665","article-title":"Endothelium-dependent and independent vasodilation studies at normoglycaemia in type I diabetes mellitus with and without microalbuminuria","volume":"44","author":"Dogra","year":"2001","journal-title":"Diabetologia"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib40","first-page":"159","article-title":"Plasma endothelin levels in NIDDM patients with macroangiopathy","volume":"25","author":"Donatelli","year":"1994","journal-title":"Diabetes Res"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib41","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1172\/JCI200318127","article-title":"Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells","volume":"112","author":"Du","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib42","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1016\/S0140-6736(99)04410-4","article-title":"Treatment of hypertension with ascorbic acid","volume":"354","author":"Duffy","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib43","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/1056-8727(92)90045-M","article-title":"Aldose reductase inhibitors as pathobiochemical probes","volume":"6","author":"Dvornik","year":"1992","journal-title":"J Diabetes Its Complicat"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib44","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1172\/JCI116481","article-title":"Accumulation of Maillard reaction products in skin collagen in diabetes and aging","volume":"91","author":"Dyer","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib45","doi-asserted-by":"crossref","first-page":"11811","DOI":"10.1016\/S0021-9258(19)50272-1","article-title":"CD36 is a receptor for oxidized low density lipoprotein","volume":"268","author":"Endemann","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib46","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/0002-8703(80)90379-8","article-title":"Clinical and morphological features of human hypertensive-diabetic cardiomyopathy","volume":"99","author":"Factor","year":"1980","journal-title":"Am Heart J"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib47","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1056\/NEJM198002143020706","article-title":"Capillary microaneurysms in the human diabetic heart","volume":"302","author":"Factor","year":"1980","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib48","first-page":"219","article-title":"Hypertensive diabetic cardiomyopathy in the rat: an experimental model of human disease","volume":"102","author":"Factor","year":"1981","journal-title":"Am J Pathol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib49","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1210\/er.2003-0012","article-title":"Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications","volume":"25","author":"Fang","year":"2004","journal-title":"Endocr Rev"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib50","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.yjmcc.2003.09.007","article-title":"Heme oxygenase in diabetes-induced oxidative stress in the heart","volume":"35","author":"Farhangkhoee","year":"2003","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib51","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s00125-005-1801-8","article-title":"Glucose-induced upregulation of CD36 mediates oxidative stress and microvascular endothelial cell dysfunction","volume":"48","author":"Farhangkhoee","year":"2005","journal-title":"Diabetologia"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib52","first-page":"74","article-title":"Endothelial dysfunction in diabetes mellitus: role in cardiovascular disease","volume":"1","author":"Feener","year":"2001","journal-title":"Heart Fail Monit"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib53","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF00877091","article-title":"Diabetic cardiomyopathy","volume":"8","author":"Fein","year":"1994","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib54","doi-asserted-by":"crossref","first-page":"22810","DOI":"10.1074\/jbc.271.37.22810","article-title":"Endothelial nitric oxide synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells","volume":"271","author":"Feron","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib55","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1074\/jbc.273.6.3125","article-title":"The endothelial nitric-oxide synthase-caveolin regulatory cycle","volume":"273","author":"Feron","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib56","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1172\/JCI0214080","article-title":"The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus","volume":"109","author":"Finck","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib57","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1073\/pnas.0336724100","article-title":"A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content","volume":"100","author":"Finck","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib58","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S0008-6363(99)00094-2","article-title":"Signal transduction of eNOS activation","volume":"43","author":"Fleming","year":"1999","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib59","first-page":"R1","article-title":"Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase","volume":"284","author":"Fleming","year":"2003","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib60","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/S0002-9149(03)00661-1","article-title":"One-year follow-up of direct myocardial gene transfer of vascular endothelial growth factor-2 using naked plasmid deoxyribonucleic acid by way of thoracotomy in no-option patients","volume":"92","author":"Fortuin","year":"2003","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib61","first-page":"H1","article-title":"PPAR-a effects on the heart and other vascular tissues","volume":"285","author":"Francis","year":"2003","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib62","doi-asserted-by":"crossref","first-page":"38484","DOI":"10.1074\/jbc.M211824200","article-title":"Aldose reductase induced by hyperosmotic stress mediates cardiomyocyte apoptosis: differential effects of sorbitol and mannitol","volume":"278","author":"Galvez","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib63","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2337\/diab.23.2.105","article-title":"Morbidity and mortality in diabetics in the Framingham population: sixteen year follow-up study","volume":"23","author":"Garcia","year":"1974","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib64","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1046\/j.1365-201X.2003.01161.x","article-title":"Peroxisome proliferator-activated receptors (PPARs): regulators of gene expression in heart and skeletal muscle","volume":"178","author":"Gilde","year":"2003","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib65","first-page":"H295","article-title":"Changes in protein kinase C in early cardiomyopathy and in gracilis muscle in the BB\/Wor diabetic rat","volume":"274","author":"Giles","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib66","doi-asserted-by":"crossref","first-page":"196","DOI":"10.2337\/diabetes.33.2.196","article-title":"Direct measurement of polyol pathway activity in the ocular lens","volume":"33","author":"Gonzalez","year":"1984","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib67","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1172\/JCI112977","article-title":"Role of sorbitol accumulation and myo-inositol depletion in paranodal swelling of large myelinated nerve fibers in the insulin-deficient spontaneously diabetic bio-breeding rat. Reversal by insulin replacement, an aldose reductase inhibitor, and myo-inositol","volume":"79","author":"Greene","year":"1987","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib68","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1161\/01.CIR.0000093660.86242.BB","article-title":"Oxidative stress and cardiovascular injury: I. Basic mechanisms and in vivo monitoring of ROS","volume":"108","author":"Griendling","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib69","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1152\/physiolgenomics.00125.2002","article-title":"Upregulation of PKC genes and isozymes in cardiovascular tissues during early stages of experimental diabetes","volume":"12","author":"Guo","year":"2003","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib70","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1161\/01.CIR.0000012748.58444.08","article-title":"Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase","volume":"105","author":"Guzik","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib71","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/ajh\/5.3.161","article-title":"Increased plasma levels of endothelin in diabetic patients with hypertension","volume":"5","author":"Haak","year":"1992","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib72","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1111\/j.1464-5491.2004.01332.x","article-title":"Enhancement of insulin-stimulated myocardial glucose uptake in patients with type 2 diabetes treated with rosiglitazone","volume":"21","author":"Hallsten","year":"2004","journal-title":"Diabet Med"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib73","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1001\/jama.229.13.1749","article-title":"Diabetic cardiomyopathy","volume":"229","author":"Hamby","year":"1974","journal-title":"JAMA"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib74","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/nm834","article-title":"Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy","volume":"9","author":"Hammes","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib75","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1042\/CS20040057","article-title":"Diabetic cardiomyopathy: mechanisms, diagnosis and treatment","volume":"107","author":"Hayat","year":"2004","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib76","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1161\/01.CIR.0000070540.80780.92","article-title":"Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: Phase II. Results of the Kuopio Angiogenesis Trial (KAT)","volume":"107","author":"Hedman","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib77","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1053\/euhj.2000.2278","article-title":"\u2018It all used to be so simple in the old days\u2019; a personal view","volume":"22","author":"Henderson","year":"2001","journal-title":"Eur Heart J"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib78","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0895-7061(03)00976-2","article-title":"Peroxynitrite versus nitric oxide in early diabetes","volume":"16","author":"Hoeldtke","year":"2003","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib79","doi-asserted-by":"crossref","first-page":"937","DOI":"10.2337\/diabetes.47.6.937","article-title":"Insulin increases endothelin-1-evoked intracellular free calcium responses by increased ET(A) receptor expression in rat aortic smooth muscle cells","volume":"47","author":"Hopfner","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib80","first-page":"89","article-title":"New concepts and insights on pathogenesis and treatment of diabetic complications: polyol pathway and its inhibition","volume":"60","author":"Hotta","year":"1997","journal-title":"Nagoya J Med Sci"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib81","doi-asserted-by":"crossref","first-page":"11059","DOI":"10.1073\/pnas.89.22.11059","article-title":"Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation","volume":"89","author":"Inoguchi","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib82","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.2337\/diabetes.49.11.1939","article-title":"High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells","volume":"49","author":"Inoguchi","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib83","doi-asserted-by":"crossref","first-page":"S227","DOI":"10.1097\/01.ASN.0000077407.90309.65","article-title":"Protein kinase C-dependent increase in reactive oxygen species (ROS) production in vascular tissues of diabetes: role of vascular NAD(P)H oxidase","volume":"14","author":"Inoguchi","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib84","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1126\/science.272.5262.728","article-title":"Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor","volume":"272","author":"Ishii","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib85","first-page":"1593","article-title":"VEGF gene transfer for diabetic neuropathy","volume":"12","author":"Isner","year":"2001","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib86","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1161\/01.CIR.98.19.2065","article-title":"Cardiac endothelin-1 plays a critical role in the functional deterioration of left ventricles during the transition from compensatory hypertrophy to congestive heart failure in salt-sensitive hypertensive rats","volume":"98","author":"Iwanaga","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib87","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1007\/BF02637057","article-title":"The effect of modest vitamin E supplementation on lipid peroxidation products and other cardiovascular risk factors in diabetic patients","volume":"31","author":"Jain","year":"1996","journal-title":"Lipids"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib88","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/S0735-1097(99)00436-2","article-title":"Abnormal cardiac function in the streptozotocin-induced non-insulin-dependent diabetic rat: noninvasive assessment with Doppler echocardiography and contribution of the nitric oxide pathway","volume":"34","author":"Joffe","year":"1999","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib89","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/eye.1993.55","article-title":"The Maillard or browning reaction in diabetes","volume":"7","author":"John","year":"1993","journal-title":"Eye"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib90","doi-asserted-by":"crossref","first-page":"448","DOI":"10.2337\/diacare.27.2.448","article-title":"Cardiac abnormalities in diabetic patients with neuropathy: effects of aldose reductase inhibitor administration","volume":"27","author":"Johnson","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib91","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1161\/01.CIR.88.6.2510","article-title":"Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus","volume":"88","author":"Johnstone","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib92","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1146\/annurev.pa.25.040185.003355","article-title":"The pharmacology of aldose reductase inhibitors","volume":"25","author":"Kador","year":"1985","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib93","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.metabol.2003.12.002","article-title":"The relationship between glycemic control and plasma vascular endothelial growth factor and endothelin-1 concentration in diabetic patients","volume":"53","author":"Kakizawa","year":"2004","journal-title":"Metabolism"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib94","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1161\/hc3801.097806","article-title":"Improved arterial compliance by a novel advanced glycation end-product crosslink breaker","volume":"104","author":"Kass","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib95","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/BF02766802","article-title":"A comparison of ultrastructural changes on endomyocardial biopsy specimens obtained from patients with and without diabetes mellitus with and without hypertension","volume":"12","author":"Kawaguchi","year":"1997","journal-title":"Heart Vessels"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib96","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1139\/y03-053","article-title":"Endothelins in chronic diabetic complications","volume":"81","author":"Khan","year":"2003","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib97","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1155\/EDR.2003.287","article-title":"Growth factors in proliferative diabetic retinopathy","volume":"4","author":"Khan","year":"2003","journal-title":"Exp Diabesity Res"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib98","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1167\/iovs.03-0540","article-title":"Oncofetal fibronectin in diabetic retinopathy","volume":"45","author":"Khan","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib99","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.bbrc.2005.01.135","article-title":"Glucose-induced serum-and glucocorticoid-regulated kinase activation in oncofetal fibronectin expression","volume":"329","author":"Khan","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib100","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1161\/01.ATV.0000160549.60980.a8","article-title":"Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta","volume":"25","author":"Kim","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib101","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00418-004-0678-9","article-title":"Hyperglycemia-induced oxidative stress in diabetic complications","volume":"122","author":"King","year":"2004","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib102","first-page":"373","article-title":"Gene therapy of coronary artery disease with phvegf165-early outcome","volume":"59","author":"Kolsut","year":"2003","journal-title":"Kardiol Pol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib103","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1536\/ihj.29.1","article-title":"Increased mortality of diabetics after acute myocardial infarction attributed to diffusely impaired left ventricular performance as assessed by echocardiography","volume":"29","author":"Kouvaras","year":"1988","journal-title":"Jpn Heart J"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib104","doi-asserted-by":"crossref","first-page":"859","DOI":"10.2337\/diabetes.47.6.859","article-title":"Protein kinase C activation and the development of diabetic complications","volume":"47","author":"Koya","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib105","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1161\/01.ATV.16.5.705","article-title":"Endothelium-dependent and-independent vasodilation of large arteries in normoalbuminuric insulin-dependent diabetes mellitus","volume":"16","author":"Lambert","year":"1996","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib106","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1016\/S0022-2828(95)91263-0","article-title":"Increased endothelin-1 gene expression in the endothelium of coronary arteries and endocardium in the DOCA-salt hypertensive rat","volume":"27","author":"Lariviere","year":"1995","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib107","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/BF00569929","article-title":"The role of endothelium in the pathogenesis of diabetic microangiopathy","volume":"30","author":"La Selva","year":"1993","journal-title":"Acta Diabetol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib108","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1210\/en.2003-0288","article-title":"Lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors","volume":"144","author":"Lee","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib109","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00019501-199602000-00001","article-title":"Diabetic cardiomyopathy: an overview","volume":"7","author":"Lewinter","year":"1996","journal-title":"Coron Artery Dis"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib110","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1023\/A:1007224828753","article-title":"In vivo effects of vanadium on GLUT4 translocation in cardiac tissue of STZ-diabetic rats","volume":"217","author":"Li","year":"2001","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib111","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1083\/jcb.126.1.111","article-title":"Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease","volume":"126","author":"Lisanti","year":"1994","journal-title":"J Cell Biol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib112","first-page":"E798","article-title":"Changes in cardiac protein kinase C activities and isozymes in streptozotocin-induced diabetes","volume":"277","author":"Liu","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib113","first-page":"H2587","article-title":"Glycation end-product cross-link breaker reduces collagen and improves cardiac function in aging diabetic heart","volume":"285","author":"Liu","year":"2003","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib114","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1161\/01.CIR.0000139850.08365.EC","article-title":"Laminar flow activates peroxisome proliferator-activated receptor-gamma in vascular endothelial cells","volume":"110","author":"Liu","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib115","first-page":"543","article-title":"Clinical correlation between diabetic and non diabetic patients with myocardial infarction","volume":"46","author":"Lomuscio","year":"1991","journal-title":"Acta Cardiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib116","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1161\/01.CIR.98.25.2800","article-title":"Gene therapy for myocardial angiogenesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia","volume":"98","author":"Losordo","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib117","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1161\/01.CIR.0000015982.70785.B7","article-title":"Phase 1\/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia","volume":"105","author":"Losordo","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib118","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev.pharmtox.37.1.517","article-title":"The heme oxygenase system: a regulator of second messenger gases","volume":"37","author":"Maines","year":"1997","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib119","article-title":"PKC{epsilon} dependent survival signals in the diabetic heart","author":"Malhotra","year":"2005","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib120","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1006\/phrs.1999.0480","article-title":"Antioxidant vitamins and prevention of cardiovascular disease: laboratory, epidemiological and clinical trial data","volume":"40","author":"Marchioli","year":"1999","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib121","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1073\/pnas.96.5.2301","article-title":"Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes","volume":"96","author":"Masutani","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib122","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2165\/00002018-199921040-00002","article-title":"Antioxidant vitamin supplements","volume":"21","author":"Maxwell","year":"1999","journal-title":"Drug Safety"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib123","first-page":"378","article-title":"Left ventricular mass and systolic function in African diabetic patients: association with microalbuminuria","volume":"27","author":"Mbanya","year":"2001","journal-title":"Diabetes Metab"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib124","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1172\/JCI116482","article-title":"Maillard reaction products and their relation to complications in insulin-dependent diabetes mellitus","volume":"91","author":"McCance","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib125","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/BF00429099","article-title":"Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus","volume":"35","author":"McVeigh","year":"1992","journal-title":"Diabetologia"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib126","first-page":"H1841","article-title":"Paracrine effects of endocardial endothelial cells on myocyte contraction mediated via endothelin","volume":"265","author":"Mebazaa","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib127","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1042\/bj3320281","article-title":"The extended protein kinase C superfamily","volume":"332","author":"Mellor","year":"1998","journal-title":"Biochem J"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib128","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1681\/ASN.V1191744","article-title":"Advanced glycation and lipoxidation end products: role of reactive carbonyl compounds generated during carbohydrate and lipid metabolism","volume":"9","author":"Miyata","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib129","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1253\/jcj.65.783","article-title":"Abnormal myocardial free fatty acid utilization deteriorates with morphological changes in the hypertensive heart","volume":"9","author":"Nakayama","year":"2001","journal-title":"Jpn Circ J"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib130","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/35008121","article-title":"Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage","volume":"404","author":"Nishikawa","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib131","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2220\/biomedres.15.291","article-title":"Endothelin expression during rat heart development: an immunohistochemical and in situ hybridization study","volume":"15","author":"Nishimura","year":"1994","journal-title":"Biomed Res"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib132","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1161\/01.CIR.93.10.1905","article-title":"Aminoguanidine prevents the decreased myocardial compliance produced by streptozotocin-induced diabetes mellitus in rats","volume":"93","author":"Norton","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib133","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/BF02066486","article-title":"Quantitative approach to the histopathology of the biopsied right ventricular myocardium in patients with diabetes mellitus","volume":"1","author":"Nunoda","year":"1985","journal-title":"Heart Vessels"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib134","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/10623320490482664","article-title":"Endothelial function and oxidative stress","volume":"11","author":"Ogita","year":"2004","journal-title":"Endothelium"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib135","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1161\/01.CIR.97.21.2175","article-title":"Induction of plasminogen activator inhibitor type 1 and type 1 collagen expression in rat cardiac microvascular endothelial cells by interleukin-1 and its dependence on oxygen-centered free radicals","volume":"97","author":"Okada","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib136","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/sj.cr.7290322","article-title":"Ultrastructure and histochemistry of rat myocardial capillary endothelial cells in response to diabetes and hypertension","volume":"15","author":"Okruhlicova","year":"2005","journal-title":"Cell Res"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib137","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1136\/heart.89.suppl_3.iii18","article-title":"A clinical approach to the assessment of left ventricular diastolic function by Doppler echocardiography: update 2003","volume":"89","author":"Ommen","year":"2003","journal-title":"Heart"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib138","doi-asserted-by":"crossref","first-page":"514","DOI":"10.2337\/diabetes.51.2.514","article-title":"The role of poly(ADP-ribose) polymerase activation in the development of myocardial and endothelial dysfunction in diabetes","volume":"51","author":"Pacher","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib139","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1006\/jmcc.2002.2084","article-title":"Advanced glycation endproduct-induced calcium handling impairment in mouse cardiac myocytes","volume":"34","author":"Petrova","year":"2002","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib140","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.2337\/diab.46.2.S82","article-title":"Aldose reductase inhibitors: the end of an era or the need for different trial designs?","volume":"46","author":"Pfeifer","year":"1997","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib141","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1073\/pnas.96.6.3059","article-title":"Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes","volume":"96","author":"Pieper","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib142","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/BF00571939","article-title":"The pathomorphological alterations of endocardial endothelium in experimental diabetes and diabetes associated with hyperlipidemia","volume":"33","author":"Popov","year":"1996","journal-title":"Acta Diabetol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib143","doi-asserted-by":"crossref","first-page":"24173","DOI":"10.1016\/S0021-9258(18)35745-4","article-title":"Generation of superoxide by purified brain nitric oxide synthase","volume":"267","author":"Pou","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib144","doi-asserted-by":"crossref","first-page":"9573","DOI":"10.1074\/jbc.274.14.9573","article-title":"Mechanism of superoxide generation by neuronal nitric-oxide synthase","volume":"274","author":"Pou","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib145","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.2337\/diabetes.46.11.1881","article-title":"Upregulation of mesangial growth factor and extracellular matrix synthesis by advanced glycation end products via a receptor-mediated mechanism","volume":"46","author":"Pugliese","year":"1997","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib146","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/BF00452074","article-title":"Diastolic abnormalities might precede systolic abnormalities of left ventricular function in type 1 (insulin-dependent) diabetes mellitus","volume":"29","author":"Punzengruber","year":"1986","journal-title":"Diabetologia"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib147","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0272-6386(00)70189-2","article-title":"Advanced glycation end products: a nephrologist's perspective","volume":"35","author":"Raj","year":"2000","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib148","doi-asserted-by":"crossref","first-page":"292","DOI":"10.2337\/diabetes.46.2.292","article-title":"Aldose reductase inhibition protects diabetic and non-diabetic rat hearts from ischemic injury","volume":"46","author":"Ramasamy","year":"1997","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib149","first-page":"H195","article-title":"Metabolic effects of aldose reductase inhibition during low-flow ischemia and reperfusion","volume":"275","author":"Ramasamy","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib150","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1023\/A:1006882805197","article-title":"Metabolic disturbances in diabetic cardiomyopathy","volume":"180","author":"Rodrigues","year":"1998","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib151","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1475-2840-2-16","article-title":"Trimetazidine improves left ventricular function in diabetic patients with coronary artery disease: a double-blind placebo-controlled study","volume":"28","author":"Rosano","year":"2003","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib152","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1161\/01.CIR.100.5.468","article-title":"Angiogenesis gene therapy: Phase I. Assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease","volume":"100","author":"Rosengart","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib153","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0168-8227(90)90086-9","article-title":"The effect of an aldose reductase inhibitor on cardiovascular performance in patients with diabetes mellitus","volume":"10","author":"Roy","year":"1990","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib154","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0002-9149(72)90595-4","article-title":"New type of cardiomyopathy associated with diabetic glomerulosclerosis","volume":"30","author":"Rubler","year":"1972","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib155","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s00125-003-1156-y","article-title":"Alteration in haemodynamics and pathological changes in the cardiovascular system during the development of Type 2 diabetes mellitus in OLETF rats","volume":"46","author":"Saito","year":"2003","journal-title":"Diabetologia"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib156","doi-asserted-by":"crossref","first-page":"F1144","DOI":"10.1152\/ajprenal.00221.2004","article-title":"NAD(P)H oxidase and uncoupled nitric oxide synthase are major sources of glomerular superoxide in rats with experimental diabetic nephropathy","volume":"288","author":"Satoh","year":"2005","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib157","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0002-9149(88)91199-X","article-title":"Acute myocardial infarction in diabetes mellitus and significance of congestive heart failure as a prognostic factor","volume":"62","author":"Savage","year":"1988","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib158","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1001\/jama.288.20.2579","article-title":"Molecular understanding of hyperglycemia's adverse effects for diabetic complications","volume":"288","author":"Sheetz","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib159","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/clc.4960180604","article-title":"Cardiac consequences of diabetes mellitus","volume":"18","author":"Shehadeh","year":"1995","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib160","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2174\/1568006033481375","article-title":"Selective protein kinase C inhibitors and their applications","volume":"3","author":"Shen","year":"2003","journal-title":"Curr Drug Targets Cardiovasc Haematol Disord"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib161","series-title":"Diabetes atlas 2003","first-page":"15","article-title":"The global burden of diabetes","author":"Sicree","year":"2003"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib162","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1111\/j.1464-5491.2004.01345.x","article-title":"Aldose reductase gene polymorphisms and susceptibility to microvascular complications in Type 2 diabetes","volume":"21","author":"Sivenius","year":"2004","journal-title":"Diabet Med"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib163","first-page":"1159","article-title":"Characterisation of a novel AGE-compound derived from lysine and 3-deoxyglucosone","volume":"44","author":"Skovsted","year":"1998","journal-title":"Cell Mol Biol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib164","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.freeradbiomed.2004.04.001","article-title":"Evidence for contribution of vascular NAD(P)H oxidase to increased oxidative stress in animal models of diabetes and obesity","volume":"37","author":"Sonta","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib165","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/BF00228090","article-title":"The effect of oxidants on biomembranes and cellular metabolism","volume":"19","author":"Srivastava","year":"1989","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib166","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0009-2797(02)00214-4","article-title":"Regulation of aldose reductase and the polyol pathway activity by nitric oxide","volume":"143\u2013144","author":"Srivastava","year":"2003","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib167","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1210\/er.2004-0028","article-title":"Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options","volume":"26","author":"Srivastava","year":"2005","journal-title":"Endocr Rev"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib168","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1046\/j.1472-8206.2003.00154.x","article-title":"Metabolic therapy in the treatment of ischaemic heart disease: the pharmacology of trimetazidine","volume":"17","author":"Stanley","year":"2003","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib169","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.2337\/diabetes.49.7.1231","article-title":"Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production","volume":"49","author":"Steinberg","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib170","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1365-2559.1989.tb02200.x","article-title":"Endomyocardial biopsy pathology in insulin-dependent diabetic patients with abnormal ventricular function","volume":"14","author":"Sutherland","year":"1989","journal-title":"Histopathology"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib171","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1358\/dnp.2002.15.4.840052","article-title":"PARP as a drug target for the therapy of diabetic cardiovascular dysfunction","volume":"4","author":"Szabo","year":"2002","journal-title":"Drug News Perspect"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib172","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.2337\/diabetes.54.7.2188","article-title":"The effect of ruboxistaurin on visual loss in patients with moderately severe to very severe nonproliferative diabetic retinopathy: initial results of the Protein Kinase C beta Inhibitor Diabetic Retinopathy Study (PKC-DRS) multicenter randomized clinical trial","volume":"54","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib173","first-page":"1013","article-title":"Cell activation by glycated proteins. AGE receptors, receptor recognition factors and functional classification of AGEs","volume":"44","author":"Thornalley","year":"1998","journal-title":"Cell Mol Biol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib174","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S0735-1097(97)00536-6","article-title":"Vitamin C improves endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus","volume":"31","author":"Timimi","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib175","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1172\/JCI118394","article-title":"Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus","volume":"97","author":"Ting","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib176","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1007\/s001250051439","article-title":"Mitogen-activated protein kinases as glucose transducers for diabetic complications","volume":"42","author":"Tomlinson","year":"1999","journal-title":"Diabetologia"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib177","first-page":"H75","article-title":"Aldose reductase inhibition improves altered glucose metabolism of isolated diabetic rat hearts","volume":"275","author":"Trueblood","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib178","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1177\/106002809302700616","article-title":"Aldose reductase inhibitors: an update","volume":"27","author":"Tsai","year":"1993","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib179","doi-asserted-by":"crossref","first-page":"11278","DOI":"10.1074\/jbc.275.15.11278","article-title":"High density lipoprotein prevents oxidized low density lipoprotein-induced inhibition of endothelial nitric-oxide synthase localization and activation in caveolae","volume":"275","author":"Uittenbogaard","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib180","first-page":"837","article-title":"United Kingdom prospective diabetic study","volume":"352","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib181","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0008-6363(01)00379-0","article-title":"Impaired endothelium-dependent vasodilation in type 2 diabetes mellitus and the lack of effect of simvastatin","volume":"52","author":"van de Ree","year":"2001","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib182","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1016\/j.ehj.2004.06.034","article-title":"Trimetazidine improves left ventricular function and quality of life in elderly patients with coronary artery disease","volume":"25","author":"Vitale","year":"2004","journal-title":"Eur Heart J"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib183","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/dmrr.233","article-title":"The AGE-receptor in the pathogenesis of diabetic complications","volume":"17","author":"Vlassara","year":"2001","journal-title":"Diabetes\/Metab Res Rev"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib184","doi-asserted-by":"crossref","first-page":"9320","DOI":"10.1073\/pnas.94.17.9320","article-title":"Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy","volume":"19","author":"Wakasaki","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib185","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.2337\/diacare.26.8.2410","article-title":"Phenotypic heterogeneity and associations of two aldose reductase gene polymorphisms with nephropathy and retinopathy in type 2 diabetes","volume":"26","author":"Wang","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib186","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.metabol.2004.11.017","article-title":"Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone reduces clinical inflammatory responses in type 2 diabetes with coronary artery disease after coronary angioplasty","volume":"54","author":"Wang","year":"2005","journal-title":"Metabolism"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib187","first-page":"E685","article-title":"Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE","volume":"280","author":"Wautier","year":"2001","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib188","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1046\/j.0742-3071.2001.00638.x","article-title":"Protein kinase C and the development of diabetic vascular complications","volume":"18","author":"Way","year":"2001","journal-title":"Diabet Med"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib189","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.2337\/diabetes.51.9.2709","article-title":"Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and diabetes","volume":"51","author":"Way","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib190","first-page":"159","article-title":"Ruboxistaurin (Eli Lilly)","volume":"6","author":"Wheeler","year":"2003","journal-title":"IDrugs"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib191","doi-asserted-by":"crossref","first-page":"801","DOI":"10.2337\/diabetes.42.6.801","article-title":"Hyperglycemic pseudohypoxia and diabetic complications","volume":"42","author":"Williamson","year":"1993","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib192","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.bbrc.2004.04.138","article-title":"Streptozotocin directly impairs cardiac contractile function in isolated ventricular myocytes via a p38 map kinase-dependent oxidative stress mechanism","volume":"318","author":"Wold","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib193","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1038\/labinvest.3700178","article-title":"Extracellular signal-regulated kinase (ERK) in glucose-induced and endothelin-mediated fibronectin synthesis","volume":"84","author":"Xin","year":"2004","journal-title":"Lab Invest"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib194","doi-asserted-by":"crossref","DOI":"10.1007\/s00125-005-1939-4","article-title":"Glucose-induced Akt1 activation mediates fibronectin synthesis in endothelial cells","author":"Xin","year":"2005","journal-title":"Diabetologia"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib195","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/path.1711660308","article-title":"Human coronary microvessels in diabetes and ischaemia. Morphometric study of autopsy material","volume":"166","author":"Yarom","year":"1992","journal-title":"J Pathol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib196","first-page":"427","article-title":"Systolic and diastolic left ventricular dysfunction in middle-aged asymptomatic non-insulin-dependent diabetics","volume":"22","author":"Yasuda","year":"1992","journal-title":"J Cardiol"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib197","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1161\/01.CIR.0000162472.52990.36","article-title":"Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of local vascular endothelial growth factor","volume":"111","author":"Yoon","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib198","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1161\/01.RES.87.5.412","article-title":"Protein kinase C activation contributes to microvascular barrier dysfunction in the heart at early stages of diabetes","volume":"87","author":"Yuan","year":"2000","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2005.10.008_bib199","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1056\/NEJMoa032566","article-title":"Diastolic heart failure: abnormalities in active relaxation and passive stiffness of the left ventricle","volume":"350","author":"Zile","year":"2004","journal-title":"N Engl J Med"}],"container-title":["Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725805002299?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725805002299?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T18:46:37Z","timestamp":1683312397000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725805002299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":199,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S0163725805002299"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2005.10.008","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2006,8]]}}}