{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:02:38Z","timestamp":1791234158444,"version":"4.1.0"},"reference-count":159,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1016\/j.pharmthera.2006.05.004","type":"journal-article","created":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T13:34:59Z","timestamp":1152711299000},"page":"513-528","source":"Crossref","is-referenced-by-count":80,"title":["Low dose acute alcohol effects on GABAA receptor subtypes"],"prefix":"10.1016","volume":"112","author":[{"given":"Martin","family":"Wallner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Jacob","family":"Hanchar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W.","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharmthera.2006.05.004_bib1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0014-2999(90)90349-B","article-title":"Ethanol potentiates the GABAA-activated Cl\u2212 current in mouse hippocampal and cortical neurons","volume":"187","author":"Aguayo","year":"1990","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib2","doi-asserted-by":"crossref","first-page":"869","DOI":"10.2174\/1568026023393426","article-title":"GABAA receptors as molecular sites of ethanol action. Direct or indirect actions?","volume":"2","author":"Aguayo","year":"2002","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1530-0277.1991.tb01862.x","article-title":"Ethanol-induced changes in chloride flux are mediated by both GABAA and GABAB receptors","volume":"15","author":"Allan","year":"1991","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib4","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/0091-3057(91)90169-3","article-title":"Ro15-4513 antagonizes the anxiolytic effects of ethanol in a nonshock conflict task at doses devoid of anxiogenic activity","volume":"39","author":"Becker","year":"1991","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib5","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0014-5793(98)00803-5","article-title":"Pharmacology of recombinant GABAA receptors rendered diazepam-insensitive by point-mutated \u03b1-subunits","volume":"431","author":"Benson","year":"1998","journal-title":"FEBS Lett"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib6","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1074\/jbc.M311371200","article-title":"On the benzodiazepine binding pocket in GABAA receptors","volume":"279","author":"Berezhnoy","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib7","doi-asserted-by":"crossref","first-page":"10934","DOI":"10.1523\/JNEUROSCI.23-34-10934.2003","article-title":"Neurosteroids shift partial agonist activation of GABAA receptor channels from low- to high-efficacy gating patterns","volume":"23","author":"Bianchi","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1073\/pnas.012682399","article-title":"A pervasive mechanism for analgesia: activation of GIRK2 channels","volume":"100","author":"Blednov","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib9","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.bcp.2004.07.023","article-title":"GABAA receptor subunit mutant mice: new perspectives on alcohol actions","volume":"68","author":"Boehm","year":"2004","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib10","first-page":"463P","article-title":"A partial inverse benzodiazepine agonist Ro15-4513 antagonizes acute ethanol effects in mice and rats","volume":"86","author":"Bonetti","year":"1985","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib11","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/0091-3057(88)90259-6","article-title":"Ro15-4513: partial inverse agonism at the BZR and interaction with ethanol","volume":"31","author":"Bonetti","year":"1988","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib12","first-page":"309","article-title":"The neuroanatomical specificity of ethanol action on ligand-gated ion channels: a hypothesis","volume":"2","author":"Breese","year":"1993","journal-title":"Alcohol Alcohol Suppl"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib13","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/j.0145-6008.2006.00086.x","article-title":"Basis of the GABA-mimetic profile of ethanol","volume":"30","author":"Breese","year":"2006","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib14","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1113\/jphysiol.1996.sp021806","article-title":"Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptors","volume":"497","author":"Brickley","year":"1996","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib15","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/sj.bjp.0704795","article-title":"Pharmacological characterization of a novel cell line expressing human \u03b14\u03b23\u03b4 GABAA receptors","volume":"136","author":"Brown","year":"2002","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.alcohol.2003.07.003","article-title":"AA and ANA rats exhibit the R100Q mutation in the GABAA receptor \u03b16 subunit","volume":"31","author":"Carr","year":"2003","journal-title":"Alcohol"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib17","doi-asserted-by":"crossref","first-page":"6813","DOI":"10.1073\/pnas.1137276100","article-title":"Alcohol potently inhibits the kainate receptor-dependent excitatory drive of hippocampal interneurons","volume":"100","author":"Carta","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib18","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.1523\/JNEUROSCI.0067-04.2004","article-title":"Alcohol enhances GABAergic transmission to cerebellar granule cells via an increase in Golgi cell excitability","volume":"24","author":"Carta","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib19","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1097\/01.alc.0000175073.94575.86","article-title":"Selective GABAA \u03b15 benzodiazepine inverse agonist antagonizes the neurobehavioral actions of alcohol","volume":"29","author":"Cook","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib20","doi-asserted-by":"crossref","first-page":"7801","DOI":"10.1523\/JNEUROSCI.1699-05.2005","article-title":"G-protein-gated potassium (GIRK) channels containing the GIRK2 subunit are control hubs for pharmacologically induced hypothermic responses","volume":"25","author":"Costa","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib21","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/sj.npp.1300750","article-title":"A conceptualization of integrated actions of ethanol contributing to its GABAmimetic profile: a commentary","volume":"30","author":"Criswell","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib22","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0091-3057(95)00107-8","article-title":"Antagonism by intracerebellar Ro15-4513 of acute ethanol-induced motor incoordination in mice","volume":"52","author":"Dar","year":"1995","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib23","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1097\/01.ALC.0000139817.53197.41","article-title":"Acute ethanol-induced adenosine diphosphate ribosylation regulates the functional activity of rat striatal pertussis toxin-sensitive g proteins","volume":"28","author":"Dar","year":"2004","journal-title":"Alcohol Clin Exp Res."},{"key":"10.1016\/j.pharmthera.2006.05.004_bib24","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0092-8674(03)00979-6","article-title":"A central role of the BK potassium channel in behavioral responses to ethanol in C. elegans","author":"Davies","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib25","first-page":"489","article-title":"Mechanism of action of ethanol: initial central nervous system actions","volume":"41","author":"Deitrich","year":"1989","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib26","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1111\/j.1471-4159.1992.tb10959.x","article-title":"Gamma-Aminobutyric acidA receptor pharmacology in rat cerebral cortical synaptoneurosomes","author":"DeLorey","year":"1992","journal-title":"J Neurochem"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1997.77.1.1","article-title":"Cellular and molecular neuroscience of alcoholism","volume":"77","author":"Diamond","year":"1997","journal-title":"Physiol Rev"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib28","doi-asserted-by":"crossref","first-page":"9209","DOI":"10.1074\/jbc.271.16.9209","article-title":"The major site of photoaffinity labeling of the GABAA receptor by [3H]flunitrazepam is histidine 102 of the alpha subunit","volume":"271","author":"Duncalfe","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib29","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1139\/y81-149","article-title":"Effect of low concentrations of ethanol on CA1 hippocampal neurons in vitro","volume":"59","author":"Durand","year":"1981","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib30","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/oxfordjournals.alcalc.a044985","article-title":"Alcohol and aldehyde dehydrogenase","volume":"25","author":"Ehrig","year":"1990","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.pharmthera.2006.05.004_bib31","series-title":"Initial Sensitivity to Alcohol","first-page":"61","article-title":"Finnish selective breeding studies for initial sensitivity to ethanol: update 1988 on the AT and ANT rat lines","volume":"vol. 20","author":"Eriksson","year":"1990"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib32","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/361302a0","article-title":"GABA receptors, granule cells and genes","volume":"361","author":"Farrant","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib33","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nrn1625","article-title":"Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors","volume":"6","author":"Farrant","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib34","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1124\/mol.104.002543","article-title":"Pentobarbital differentially modulates \u03b11\u03b23\u03b4 and \u03b11\u03b23\u03b32L GABAA receptor currents","volume":"66","author":"Feng","year":"2004","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib35","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0165-6147(89)80009-4","article-title":"Molecular sites of anesthetic action in postsynaptic nicotinic membranes","volume":"10","author":"Forman","year":"1989","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib36","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/292248a0","article-title":"Is membrane expansion relevant to anaesthesia?","volume":"292","author":"Franks","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib37","first-page":"750","article-title":"GABAergic modulation of ethanol-induced motor impairment","volume":"223","author":"Frye","year":"1982","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib38","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/0091-3057(88)90263-8","article-title":"Ethanol and the GABA receptor complex: studies with the partial inverse benzodiazepine receptor agonist Ro15-4513","volume":"31","author":"Glowa","year":"1988","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib39","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s002130050685","article-title":"The role of GABAA receptors in the acute and chronic effects of ethanol","volume":"139","author":"Grobin","year":"1998","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib40","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/j.1471-4159.1976.tb12295.x","article-title":"Ethanol intoxication and gamma-aminobutyric acid","volume":"27","author":"Hakkinen","year":"1976","journal-title":"J Neurochem"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lfs.2004.05.035","article-title":"Alcohol effects on GABAA receptors: are extrasynaptic receptors the answer?","volume":"76","author":"Hanchar","year":"2004","journal-title":"Life Sci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib42","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nn1398","article-title":"Alcohol-induced motor impairment caused by increased extrasynaptic GABAA receptor activity","volume":"8","author":"Hanchar","year":"2005","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib43","doi-asserted-by":"crossref","first-page":"8546","DOI":"10.1073\/pnas.0509903103","article-title":"Ethanol potently and competitively inhibits binding of the alcohol antagonist Ro15-4513 to \u03b14\/6\u03b23\u03b4 GABAA receptors","volume":"103","author":"Hanchar","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib44","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1126\/science.2581319","article-title":"Functional coupling of gamma-aminobutyric acid receptors to chloride channels in brain membranes","volume":"228","author":"Harris","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib45","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1096\/fasebj.3.6.2467834","article-title":"Alcohol intoxication: ion channels and genetics","volume":"3","author":"Harris","year":"1989","journal-title":"FASEB J"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib46","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1073\/pnas.92.9.3658","article-title":"Mutant mice lacking the gamma isoform of protein kinase C show decreased behavioral actions of ethanol and altered function of GABAA receptors","volume":"92","author":"Harris","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib47","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0091-3057(89)90333-X","article-title":"Effect of GABAergic drugs on motor impairment from ethanol, barbital and lorazepam in rat lines selected for differential sensitivity to ethanol","volume":"34","author":"Hellevuo","year":"1989","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib48","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/14795","article-title":"Supersensitivity to allosteric GABAA receptor modulators and alcohol in mice lacking PKCepsilon","volume":"2","author":"Hodge","year":"1999","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib49","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/0024-3205(87)90415-2","article-title":"Effect of an imidazobenzodiazepine, Ro15-4513, on the incoordination and hypothermia produced by ethanol and pentobarbital","volume":"41","author":"Hoffman","year":"1987","journal-title":"Life Sci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib50","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1073\/pnas.94.8.4143","article-title":"Mice devoid of GABAA receptor \u03b23 subunit have epilepsy, cleft palate, and hypersensitive behavior","volume":"94","author":"Homanics","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib51","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1124\/mol.51.4.588","article-title":"Gene knockout of the \u03b16 subunit of the GABAA receptor: lack of effect on responses to ethanol, pentobarbital, and general anesthetics","volume":"51","author":"Homanics","year":"1997","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib52","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0028-3908(98)00177-4","article-title":"Normal electrophysiological and behavioral responses to ethanol in mice lacking the long splice variant of the \u03b32 subunit of the GABAA receptor","volume":"38","author":"Homanics","year":"1999","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib53","first-page":"107","article-title":"Interaction between flurazepam and ethanol","volume":"7","author":"Hu","year":"1987","journal-title":"Alcohol Drug Res"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1001\/archneurpsyc.1950.02310250007001","article-title":"Chronic barbiturate intoxication","author":"Isbell","year":"1950","journal-title":"AMA Arch Neurol Psychiatry"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib55","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/BF02245334","article-title":"Interactions of Ro15-4513, Ro15-1788 (flumazenil) and ethanol on measures of exploration and locomotion in rats","volume":"116","author":"June","year":"1994","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib56","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1530-0277.1991.tb00538.x","article-title":"Ro15-4513 attenuates the consumption of ethanol in deprived rats","volume":"15","author":"June","year":"1991","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib57","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1096\/fj.02-0611fje","article-title":"General anesthetic actions in vivo strongly attenuated by a point mutation in the GABAA receptor \u03b23 subunit","volume":"17","author":"Jurd","year":"2003","journal-title":"FASEB J"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib58","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0091-3057(97)00477-2","article-title":"Rapid tolerance and crosstolerance to motor impairment effects of benzodiazepines, barbiturates, and ethanol","volume":"59","author":"Khanna","year":"1998","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib59","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/16019","article-title":"Ethanol opens G-protein-activated inwardly rectifying K+ channels","volume":"2","author":"Kobayashi","year":"1999","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib60","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1126\/science.3775379","article-title":"New drug counters alcohol intoxication","volume":"234","author":"Kolata","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib61","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0922-4106(93)90133-T","article-title":"Natural mutation of GABAA receptor alpha 6 subunit alters benzodiazepine affinity but not allosteric GABA effects","volume":"247","author":"Korpi","year":"1993","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib62","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0741-8329(92)90058-I","article-title":"Cerebellar GABAA receptors in two rat lines selected for high and low sensitivity to moderate alcohol doses: pharmacological and genetic studies","volume":"9","author":"Korpi","year":"1992","journal-title":"Alcohol"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib63","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/361356a0","article-title":"Benzodiazepine-induced motor impairment linked to point mutation in cerebellar GABAA receptor","volume":"361","author":"Korpi","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib64","first-page":"164","article-title":"Ethanol: novel actions on nerve cell physiology explain impaired functions","volume":"13","author":"Korpi","year":"1998","journal-title":"News Physiol Sci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib65","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0091-3057(89)90239-6","article-title":"Ro15-4513 but not FG7142 reverses anticonvulsant effects of ethanol against bicuculline- and picrotoxin-induced convulsions in rats","volume":"32","author":"Kulkarni","year":"1989","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib66","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/0006-8993(95)00286-Y","article-title":"Effects of systemic and local ethanol on responses of rat cerebellar Purkinje neurons to iontophoretically applied norepinephrine and gamma-aminobutyric acid","volume":"687","author":"Lee","year":"1995","journal-title":"Brain Res"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib67","doi-asserted-by":"crossref","first-page":"9771","DOI":"10.1073\/pnas.97.17.9771","article-title":"Activation and inhibition of G protein-coupled inwardly rectifying potassium (Kir3) channels by G protein beta gamma subunits","volume":"97","author":"Lei","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib68","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/16012","article-title":"G-protein-coupled inwardly rectifying potassium channels are targets of alcohol action","volume":"2","author":"Lewohl","year":"1999","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib69","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1523\/JNEUROSCI.4702-05.2006","article-title":"Chronic intermittent ethanol-induced switch of ethanol actions from extrasynaptic to synaptic hippocampal GABAA receptors","volume":"26","author":"Liang","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib70","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF00470592","article-title":"Effects of GABAergic agonists and antagonists on various ethanol-induced behavioral changes","author":"Liljequist","year":"1982","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib71","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/0024-3205(87)90713-2","article-title":"The benzodiazepine receptor inverse agonists FG 7142 and Ro15-4513 both reverse some of the behavioral effects of ethanol in a holeboard test","volume":"41","author":"Lister","year":"1987","journal-title":"Life Sci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib72","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0166-2236(87)90160-3","article-title":"Is Ro15-4513 a specific alcohol antagonist?","volume":"10","author":"Lister","year":"1987","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib73","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1016\/j.lfs.2005.08.027","article-title":"Comparison of psychic emergence reactions after (+\/\u2212)-ketamine and (+)-ketamine in mice","volume":"78","author":"Liu","year":"2006","journal-title":"Life Sci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib74","first-page":"263","article-title":"Ethanol potentiation of 5-hydroxytryptamine3 receptor-mediated ion current in neuroblastoma cells and isolated adult mammalian neurons","volume":"40","author":"Lovinger","year":"1991","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib75","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1126\/science.2467382","article-title":"Ethanol inhibits NMDA-activated ion current in hippocampal neurons","volume":"243","author":"Lovinger","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib76","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1126\/science.290.5489.131","article-title":"Molecular and neuronal substrate for the selective attenuation of anxiety","volume":"290","author":"Low","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib77","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/syn.890030203","article-title":"Antagonism of ethanol effects by Ro15-4513: an electrophysiological analysis","volume":"3","author":"Marrosu","year":"1989","journal-title":"Synapse"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib78","first-page":"157","article-title":"Selective effects of alcohols on GABAA receptor subunits expressed in human embryonic kidney cells","volume":"269","author":"Marszalec","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib79","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0014-2999(83)90607-6","article-title":"Behavioral evidence for the involvement of gamma-aminobutyric acid in the actions of ethanol","volume":"89","author":"Martz","year":"1983","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib80","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00213-003-1671-z","article-title":"A high affinity ligand for GABAA-receptor containing a5 subunit antagonizes ethanol's neurobehavioral effects in Long-Evans rats","volume":"172","author":"McKay","year":"2004","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib81","first-page":"558","article-title":"Ethanol potentiation of GABAergic transmission in cultured spinal cord neurons involves GABAA-gated chloride channels","volume":"246","author":"Mehta","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib82","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1126\/science.235.4793.1127a","article-title":"Seizures in drug-treated animals","volume":"235","author":"Miczek","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib83","first-page":"1708","article-title":"GABAA-receptor d subunit knockout mice have multiple defects in behavioral responses to ethanol","volume":"25","author":"Mihalek","year":"2001","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib84","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0197-0186(99)00053-4","article-title":"Acute effects of ethanol on GABAA and glycine receptor function","volume":"35","author":"Mihic","year":"1999","journal-title":"Neurochem Int"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib85","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/j.1471-4159.1992.tb09781.x","article-title":"Potentiation of gamma-aminobutyric acid-mediated chloride flux by pentobarbital and diazepam but not ethanol","volume":"58","author":"Mihic","year":"1992","journal-title":"J Neurochem"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib86","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/38738","article-title":"Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors","volume":"389","author":"Mihic","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib87","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1023\/A:1012376215967","article-title":"Distinguishing between GABAA receptors responsible for tonic and phasic conductances","volume":"26","author":"Mody","year":"2001","journal-title":"Neurochem Res"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib88","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/sj.npp.1300342","article-title":"Acute effects of ketamine on memory systems and psychotic symptoms in healthy volunteers","volume":"29","author":"Morgan","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib89","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1523\/JNEUROSCI.13-05-02264.1993","article-title":"Attenuation of hippocampal long-term potentiation by ethanol: a patch-clamp analysis of glutamatergic and GABAergic mechanisms","volume":"13","author":"Morrisett","year":"1993","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib90","first-page":"247","article-title":"Benzodiazepine, barbiturate, ethanol and hypnotic steroid hormone modulation of GABA-mediated chloride ion transport in rat brain synaptoneurosomes","volume":"45","author":"Morrow","year":"1988","journal-title":"Adv Biochem Psychopharmacol"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib91","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0165-0173(01)00127-8","article-title":"The role of GABAergic neuroactive steroids in ethanol action, tolerance and dependence","volume":"37","author":"Morrow","year":"2001","journal-title":"Brain Res Brain Res Rev"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib92","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0014-2999(88)90506-7","article-title":"Reversal of alcohol-induced amnesia by the benzodiazepine inverse agonist Ro15-4513","volume":"155","author":"Nabeshima","year":"1988","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib93","first-page":"235","article-title":"Modulation of gamma-aminobutyric acid receptor-channel complex by alcohols","volume":"259","author":"Nakahiro","year":"1991","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib94","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1749-6632.1991.tb33827.x","article-title":"Effects of alcohols on ion channels of cultured neurons","volume":"625","author":"Narahashi","year":"1991","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib95","first-page":"325","article-title":"Modulation of GABA receptor-channel complex by alcohols and general anesthetics","volume":"47","author":"Narahashi","year":"1992","journal-title":"Adv Biochem Psychopharmacol"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib96","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.pharmthera.2005.07.004","article-title":"Intracellular signaling pathways that regulate behavioral responses to ethanol","volume":"109","author":"Newton","year":"2006","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib97","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1523\/JNEUROSCI.18-05-01693.1998","article-title":"Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells","volume":"18","author":"Nusser","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib98","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1097\/00001756-200003200-00006","article-title":"Co-localization of PKCepsilon with various GABA(A) receptor subunits in the mouse limbic system","volume":"11","author":"Olive","year":"2000","journal-title":"NeuroReport"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib99","series-title":"GABA in the Nervous System: The View at Fifty Years","first-page":"81","article-title":"Function of GABAA receptors: insights from mutant and knockout mice","author":"Olsen","year":"2000"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib100","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1749-6632.1991.tb33838.x","article-title":"Allosteric actions of central nervous system depressants including anesthetics on subtypes of the inhibitory GABAA receptor-chloride channel complex","volume":"625","author":"Olsen","year":"1991","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib101","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1097\/01.ALC.0000172461.69020.59","article-title":"Response to Valenzuela et al.","volume":"29","author":"Otis","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib102","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF00972204","article-title":"GABAergic mechanisms in the electrophysiological actions of ethanol on cerebellar neurons","volume":"15","author":"Palmer","year":"1990","journal-title":"Neurochem Res"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib103","first-page":"1018","article-title":"Antagonism of ethanol effects on cerebellar Purkinje neurons by the benzodiazepine inverse agonists Ro15-4513 and FG7142: electrophysiological studies","volume":"247","author":"Palmer","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib104","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/01.ALC.0000153550.31168.1D","article-title":"CREB gene transcription factors: role in molecular mechanisms of alcohol and drug addiction","volume":"29","author":"Pandey","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib105","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/cne.10210","article-title":"GABAA receptor changes in d subunit-deficient mice: altered expression of \u03b14 and \u03b32 subunits in the forebrain","volume":"446","author":"Peng","year":"2002","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib106","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/BF02245630","article-title":"Ro15-4513 selectively attenuates ethanol, but not sucrose, reinforced responding in a concurrent access procedure; comparison to other drugs","volume":"121","author":"Petry","year":"1995","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib107","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1177\/0269881104047272","article-title":"Alcohol, wine and mental health: focus on dementia and stroke","volume":"18","author":"Pinder","year":"2004","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib108","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0306-4522(00)00442-5","article-title":"GABAA receptors: immunocytochemical distribution of 13 subunits in the adult rat brain","volume":"101","author":"Pirker","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib109","first-page":"465P","article-title":"Interactions of partial inverse benzodiazepine agonists Ro15-4513 and FG7142 with ethanol in rats and cats","volume":"86","author":"Polc","year":"1985","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib110","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1126\/science.6324348","article-title":"Behavioral sensitivity to purinergic drugs parallels ethanol sensitivity in selectively bred mice","volume":"224","author":"Proctor","year":"1984","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib111","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1124\/jpet.102.045450","article-title":"Ethanol differentially enhances hippocampal GABAA receptor-mediated responses in protein kinase C gamma (PKC gamma) and PKC epsilon null mice","volume":"305","author":"Proctor","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib112","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1023\/B:BEGE.0000023650.32243.39","article-title":"Behavioral characterization of alcohol-tolerant and alcohol non-tolerant rat lines and an f(2) generation","volume":"34","author":"Radcliffe","year":"2004","journal-title":"Behav Genet"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib113","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/S0369-8114(01)00232-2","article-title":"Research advances in ethanol metabolism","volume":"49","author":"Ramchandani","year":"2001","journal-title":"Pathol Biol (Paris)"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib114","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1530-0277.1993.tb00736.x","article-title":"GABA antagonist and benzodiazepine partial inverse agonist reduce motivated responding for ethanol","volume":"17","author":"Rassnick","year":"1993","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib115","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0014-2999(92)90802-B","article-title":"Ethanol modulation of GABA receptor-activated Cl\u2212 currents in neurons of the chick, rat and mouse central nervous system","volume":"224","author":"Reynolds","year":"1992","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib116","doi-asserted-by":"crossref","first-page":"8608","DOI":"10.1523\/JNEUROSCI.23-24-08608.2003","article-title":"Sedation and anesthesia mediated by distinct GABAA receptor isoforms","volume":"23","author":"Reynolds","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib117","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1073\/pnas.0437926100","article-title":"Ethanol increases GABAergic transmission at both pre- and postsynaptic sites in rat central amygdala neurons","volume":"100","author":"Roberto","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib118","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/44579","article-title":"Benzodiazepine actions mediated by specific GABAA receptor subtypes","volume":"401","author":"Rudolph","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib119","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0169-328X(01)00003-1","article-title":"The R100Q mutation of the GABAA \u03b16 receptor subunit may contribute to voluntary aversion to ethanol in the sNP rat line","volume":"87","author":"Saba","year":"2001","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib120","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0006-8993(02)04230-0","article-title":"Characterization of wild-type (R100R) and mutated (Q100Q) GABAA \u03b16 subunit in Sardinian alcohol non-preferring rats (sNP)","volume":"967","author":"Sanna","year":"2003","journal-title":"Brain Res"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib121","doi-asserted-by":"crossref","first-page":"795","DOI":"10.2174\/1568026023393507","article-title":"Subunit composition, distribution and function of GABAA receptor subtypes","volume":"2","author":"Sieghart","year":"2002","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib122","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/0014-5793(93)81380-I","article-title":"Recombinant GABAA receptor function and ethanol","volume":"324","author":"Sigel","year":"1993","journal-title":"FEBS Lett"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib123","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1749-6632.1987.tb48692.x","article-title":"Electrophysiology of ethanol on central neurons","volume":"492","author":"Siggins","year":"1987","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib124","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.pharmthera.2005.01.006","article-title":"The tipsy terminal: presynaptic effects of ethanol","volume":"107","author":"Siggins","year":"2005","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib125","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/0361-9230(87)90209-7","article-title":"Locally applied progesterone metabolites alter neuronal responsiveness in the cerebellum","volume":"18","author":"Smith","year":"1987","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib126","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1097\/00007611-200407000-00012","article-title":"Alcohol consumption: an overview of benefits and risks","volume":"97","author":"Standridge","year":"2004","journal-title":"South Med J"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib127","doi-asserted-by":"crossref","first-page":"14439","DOI":"10.1073\/pnas.2435457100","article-title":"Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by d subunit-containing GABAA receptors","volume":"100","author":"Stell","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib128","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nn888","article-title":"Hormonally regulated \u03b14\u03b22\u03b4 GABAA receptors are a target for alcohol","volume":"5","author":"Sundstrom-Poromaa","year":"2002","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib129","first-page":"445","article-title":"Ethanol stimulates GABA receptor-mediated Cl\u2212 ion flux in vitro: possible relationship to the anxiolytic and intoxicating actions of alcohol","volume":"23","author":"Suzdak","year":"1987","journal-title":"Psychopharmacol Bull"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib130","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1126\/science.3022383","article-title":"A selective imidazobenzodiazepine antagonist of ethanol in the rat","volume":"234","author":"Suzdak","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib131","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.1073\/pnas.83.11.4071","article-title":"Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes","volume":"83","author":"Suzdak","year":"1986","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib132","first-page":"E353","article-title":"DARPP-32 mediates the actions of multiple drugs of abuse","volume":"7","author":"Svenningsson","year":"2005","journal-title":"AAS"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib133","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/0361-9230(87)90078-5","article-title":"Ro15-4513 differentially affects ethanol-induced hypnosis and hypothermia","volume":"19","author":"Syapin","year":"1987","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib134","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1046\/j.1460-9568.2003.02988.x","article-title":"Alpha2-GABAA receptors are the molecular substrates mediating precipitation of narcosis but not of sedation by the combined use of diazepam and alcohol in vivo","volume":"18","author":"Tauber","year":"2003","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib135","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/0091-3057(88)90487-X","article-title":"Molecular interactions of ethanol with GABAergic system and potential of Ro15-4513 as an ethanol antagonist","volume":"30","author":"Ticku","year":"1988","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib136","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0361-9230(86)90168-1","article-title":"Ethanol enhances GABA-induced 36Cl-influx in primary spinal cord cultured neurons","volume":"17","author":"Ticku","year":"1986","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib137","first-page":"49","article-title":"Synaptoneurosomes. A preparation for studying subhippocampal GABAA receptor activity","volume":"72","author":"Titulaer","year":"1997","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib138","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/S0006-3495(98)77594-0","article-title":"Is there a specific receptor for anesthetics? Contrary effects of alcohols and fatty acids on phase transition and bioluminescence of firefly luciferase","volume":"75","author":"Ueda","year":"1998","journal-title":"Biophys J"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib139","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/BF00964950","article-title":"Cerebellar GABAA receptor binding and function in vitro in two rat lines developed for high and low alcohol sensitivity","volume":"14","author":"Uusi-Oukari","year":"1989","journal-title":"Neurochem Res"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib140","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1111\/j.1471-4159.1990.tb04901.x","article-title":"Diazepam sensitivity of the binding of an imidazobenzodiazepine, [3H]Ro 15-4513, in cerebellar membranes from two rat lines developed for high and low alcohol sensitivity","volume":"54","author":"Uusi-Oukari","year":"1990","journal-title":"J Neurochem"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib141","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1530-0277.1991.tb01864.x","article-title":"Specific alterations in the cerebellar GABAA receptors of an alcohol-sensitive ANT rat line","volume":"15","author":"Uusi-Oukari","year":"1991","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib142","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1097\/01.ALC.0000171926.66397.94","article-title":"Letter to the editor","volume":"29","author":"Valenzuela","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib143","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0014-5793(92)81424-K","article-title":"Ethanol potentiation of GABAA receptors requires phosphorylation of the alternatively spliced variant of the \u03b32 subunit","volume":"313","author":"Wafford","year":"1992","journal-title":"FEBS Lett"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib144","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0896-6273(91)90071-7","article-title":"Ethanol sensitivity of the GABAA receptor expressed in Xenopus oocytes requires 8 amino acids contained in the \u03b32L subunit","volume":"7","author":"Wafford","year":"1991","journal-title":"Neuron"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib145","doi-asserted-by":"crossref","first-page":"15218","DOI":"10.1073\/pnas.2435171100","article-title":"Ethanol enhances \u03b14\u03b23\u03b4 and \u03b16\u03b23\u03b4 GABAA receptors at low concentrations known to affect humans","volume":"100","author":"Wallner","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib146","doi-asserted-by":"crossref","first-page":"8540","DOI":"10.1073\/pnas.0600194103","article-title":"Low dose alcohol actions on \u03b14\u03b23\u03b4 GABAA receptors are reversed by the behavioral alcohol antagonist Ro15-4513","volume":"103","author":"Wallner","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib147","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1073\/pnas.93.10.5049","article-title":"Low ethanol concentrations enhance GABAergic inhibitory postsynaptic potentials in hippocampal pyramidal neurons only after block of GABAB receptors","volume":"93","author":"Wan","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib148","doi-asserted-by":"crossref","first-page":"10650","DOI":"10.1523\/JNEUROSCI.23-33-10650.2003","article-title":"Perisynaptic localization of d subunit-containing GABAA receptors and their activation by GABA spillover in the mouse dentate gyrus","volume":"23","author":"Wei","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib149","doi-asserted-by":"crossref","first-page":"8379","DOI":"10.1523\/JNEUROSCI.2040-04.2004","article-title":"Low ethanol concentrations selectively augment the tonic inhibition mediated by \u03b4 subunit-containing GABAA receptors in hippocampal neurons","volume":"24","author":"Wei","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib150","unstructured":"Weiner, J. L., Valenzuela, C. F. (in press). Ethanol modulation of GABAergic transmission: the view from the slice. Pharmacol Ther."},{"key":"10.1016\/j.pharmthera.2006.05.004_bib151","first-page":"1388","article-title":"Potentiation of GABAA-mediated synaptic current by ethanol in hippocampal CA1 neurons: possible role of protein kinase C","volume":"268","author":"Weiner","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib152","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1152\/jn.1997.77.3.1306","article-title":"Differential ethanol sensitivity of subpopulations of GABAA synapses onto rat hippocampal CA1 pyramidal neurons","volume":"77","author":"Weiner","year":"1997","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib153","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/0006-8993(90)90292-J","article-title":"Ethanol inhibits NMDA-activated current but does not alter GABA-activated current in an isolated adult mammalian neuron","volume":"507","author":"White","year":"1990","journal-title":"Brain Res"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib154","doi-asserted-by":"crossref","first-page":"6504","DOI":"10.1073\/pnas.95.11.6504","article-title":"Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor?","volume":"95","author":"Wick","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib155","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/S0021-9258(18)45961-3","article-title":"A single histidine in GABAA receptors is essential for benzodiazepine agonist binding","volume":"267","author":"Wieland","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib156","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1523\/JNEUROSCI.22-05-01541.2002","article-title":"Enhanced neurosteroid potentiation of ternary GABAA receptors containing the \u03b4 subunit","author":"Wohlfarth","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib157","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1615\/CritRevNeurobiol.v14.i1.40","article-title":"Ethanol and NMDA receptor signaling","volume":"14","author":"Woodward","year":"2000","journal-title":"Crit Rev Neurobiol"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib158","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev.pharmtox.41.1.23","article-title":"Anesthetics and ion channels: molecular models and sites of action","volume":"41","author":"Yamakura","year":"2001","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.pharmthera.2006.05.004_bib159","doi-asserted-by":"crossref","first-page":"14379","DOI":"10.1073\/pnas.2336093100","article-title":"Addicting drugs utilize a synergistic molecular mechanism in common requiring adenosine and Gi-beta gamma dimers","volume":"100","author":"Yao","year":"2003","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725806000908?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725806000908?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T15:07:03Z","timestamp":1627571223000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725806000908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":159,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S0163725806000908"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2006.05.004","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2006,11]]}}}