{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:07:12Z","timestamp":1792004832502,"version":"4.4.0"},"reference-count":600,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.pharmthera.2010.04.005","type":"journal-article","created":{"date-parts":[[2010,5,3]],"date-time":"2010-05-03T06:19:50Z","timestamp":1272867590000},"page":"191-227","source":"Crossref","is-referenced-by-count":768,"title":["Molecular distinction between physiological and pathological cardiac hypertrophy: Experimental findings and therapeutic strategies"],"prefix":"10.1016","volume":"128","author":[{"given":"Bianca C.","family":"Bernardo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate L.","family":"Weeks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette","family":"Pretorius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie R.","family":"McMullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"17","key":"10.1016\/j.pharmthera.2010.04.005_bib1","doi-asserted-by":"crossref","first-page":"10140","DOI":"10.1073\/pnas.95.17.10140","article-title":"Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure","volume":"95","author":"Adams","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib2","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1007\/PL00000744","article-title":"Structure and function of the type 1 insulin-like growth factor receptor","volume":"57","author":"Adams","year":"2000","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib3","series-title":"Heart, Stroke and Vascular Diseases\u2014Australian Facts 2004. Canberra, Australian Institute for Health and Welfare and National Heart Foundation of Australia (Cardiovascular Disease Series No. 22)","year":"2004"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib4","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1161\/01.RES.84.4.458","article-title":"Rho family small G proteins play critical roles in mechanical stress-induced hypertrophic responses in cardiac myocytes","volume":"84","author":"Aikawa","year":"1999","journal-title":"Circ Res"},{"issue":"10","key":"10.1016\/j.pharmthera.2010.04.005_bib5","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1161\/01.RES.0000072977.86706.23","article-title":"Roles of cardiac transcription factors in cardiac hypertrophy","volume":"92","author":"Akazawa","year":"2003","journal-title":"Circ Res"},{"issue":"5363","key":"10.1016\/j.pharmthera.2010.04.005_bib6","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1126\/science.280.5363.574","article-title":"Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy","volume":"280","author":"Akhter","year":"1998","journal-title":"Science"},{"issue":"1\u20132","key":"10.1016\/j.pharmthera.2010.04.005_bib7","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s11010-008-9711-y","article-title":"Compensated cardiac hypertrophy is characterised by a decline in palmitate oxidation","volume":"311","author":"Akki","year":"2008","journal-title":"Mol Cell Biochem"},{"issue":"2 Pt 2","key":"10.1016\/j.pharmthera.2010.04.005_bib8","first-page":"H742","article-title":"Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts","volume":"267","author":"Allard","year":"1994","journal-title":"Am J Physiol"},{"issue":"9431","key":"10.1016\/j.pharmthera.2010.04.005_bib9","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0140-6736(04)16723-8","article-title":"Long-term effects of darusentan on left-ventricular remodelling and clinical outcomes in the EndothelinA Receptor Antagonist Trial in Heart Failure (EARTH): randomised, double-blind, placebo-controlled trial","volume":"364","author":"Anand","year":"2004","journal-title":"Lancet"},{"issue":"6259","key":"10.1016\/j.pharmthera.2010.04.005_bib10","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/343651a0","article-title":"Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase","volume":"343","author":"Anderson","year":"1990","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib11","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1073\/pnas.231619298","article-title":"Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo","volume":"99","author":"Antos","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6868","key":"10.1016\/j.pharmthera.2010.04.005_bib12","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/415240a","article-title":"Myocyte renewal and ventricular remodelling","volume":"415","author":"Anversa","year":"2002","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1006\/jmcc.2001.1506","article-title":"Myocyte growth and cardiac repair","volume":"34","author":"Anversa","year":"2002","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib14","unstructured":"Aoki, H. and Izumo, S. (2001). Signal transduction of cardiac myocyte hypertrophy. Heart Physiology and Pathology. Sperelakis, N., Kurachi, Y., Terzic, A. and Cohen, M.V. San Diego, Academic Press: 1065\u20131086."},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib15","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1161\/01.RES.82.6.666","article-title":"Angiotensin II activates RhoA in cardiac myocytes: a critical role of RhoA in angiotensin II-induced premyofibril formation","volume":"82","author":"Aoki","year":"1998","journal-title":"Circ Res"},{"issue":"5 Pt 2","key":"10.1016\/j.pharmthera.2010.04.005_bib16","first-page":"H2084","article-title":"Endothelin-1 and its binding sites are upregulated in pressure overload cardiac hypertrophy","volume":"268","author":"Arai","year":"1995","journal-title":"Am J Physiol"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib17","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0092-8674(00)81878-4","article-title":"MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure","volume":"88","author":"Arber","year":"1997","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1152\/physiolgenomics.2001.6.1.19","article-title":"Divergent transcriptional responses to independent genetic causes of cardiac hypertrophy","volume":"6","author":"Aronow","year":"2001","journal-title":"Physiol Genomics"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib19","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0008-6363(01)00526-0","article-title":"Estrogenic hormone action in the heart: regulatory network and function","volume":"53","author":"Babiker","year":"2002","journal-title":"Cardiovasc Res"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib20","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/01.RES.0000197782.21444.8f","article-title":"Control of cardiac growth by histone acetylation\/deacetylation","volume":"98","author":"Backs","year":"2006","journal-title":"Circ Res"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib21","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1172\/JCI27438","article-title":"CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy","volume":"116","author":"Backs","year":"2006","journal-title":"J Clin Invest"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib22","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1073\/pnas.0813013106","article-title":"The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload","volume":"106","author":"Backs","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib23","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1172\/JCI13779","article-title":"Fas receptor signaling inhibits glycogen synthase kinase 3 beta and induces cardiac hypertrophy following pressure overload","volume":"109","author":"Badorff","year":"2002","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.yjmcc.2004.11.004","article-title":"STRESS signaling pathways that modulate cardiac myocyte apoptosis","volume":"38","author":"Baines","year":"2005","journal-title":"J Mol Cell Cardiol"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib25","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1159\/000095784","article-title":"Differential role of rho-kinase in pathological and physiological cardiac hypertrophy in rats","volume":"78","author":"Balakumar","year":"2006","journal-title":"Pharmacology"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib26","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0014-5793(95)00981-E","article-title":"The cardiac sarcoplasmic reticulum phospholamban kinase is a distinct delta-CaM kinase isozyme","volume":"373","author":"Baltas","year":"1995","journal-title":"FEBS Lett"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib27","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S1050-1738(00)00077-3","article-title":"PPAR signaling in the control of cardiac energy metabolism","volume":"10","author":"Barger","year":"2000","journal-title":"Trends Cardiovasc Med"},{"issue":"12","key":"10.1016\/j.pharmthera.2010.04.005_bib28","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1172\/JCI9056","article-title":"Deactivation of peroxisome proliferator-activated receptor-alpha during cardiac hypertrophic growth","volume":"105","author":"Barger","year":"2000","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib29","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cardiores.2004.03.011","article-title":"Network integration of the adrenergic system in cardiac hypertrophy","volume":"63","author":"Barki-Harrington","year":"2004","journal-title":"Cardiovasc Res"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib30","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1006\/bbrc.2000.4137","article-title":"Construction of a human cardiovascular cDNA microarray: portrait of the failing heart","volume":"280","author":"Barrans","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib31","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2003.10.033","article-title":"Mechanisms of thyroid hormone receptor-specific nuclear and extra nuclear actions","volume":"213","author":"Bassett","year":"2003","journal-title":"Mol Cell Endocrinol"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib33","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.coph.2008.01.002","article-title":"Targeting p38-MAPK in the ischaemic heart: kill or cure?","volume":"8","author":"Bassi","year":"2008","journal-title":"Curr Opin Pharmacol"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib34","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S0022-3565(25)23748-X","article-title":"Cardiac hypertrophy induced by thyroid hormone is independent of loading conditions and beta adrenoceptor blockade","volume":"248","author":"Bedotto","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib35","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1161\/hc0302.103712","article-title":"Pivotal role of a gp91(phox)-containing NADPH oxidase in angiotensin II-induced cardiac hypertrophy in mice","volume":"105","author":"Bendall","year":"2002","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib36","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1161\/01.RES.65.3.657","article-title":"Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis","volume":"65","author":"Benjamin","year":"1989","journal-title":"Circ Res"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib37","doi-asserted-by":"crossref","first-page":"H8","DOI":"10.1152\/ajpheart.01303.2004","article-title":"Does load-induced ventricular hypertrophy progress to systolic heart failure?","volume":"289","author":"Berenji","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"16","key":"10.1016\/j.pharmthera.2010.04.005_bib38","doi-asserted-by":"crossref","first-page":"10963","DOI":"10.1074\/jbc.274.16.10963","article-title":"Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase","volume":"274","author":"Bi","year":"1999","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib39","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/0735-1097(93)90424-Y","article-title":"Asymptomatic ventricular arrhythmias and mortality risk in subjects with left ventricular hypertrophy","volume":"22","author":"Bikkina","year":"1993","journal-title":"J Am Coll Cardiol"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib40","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1172\/JCI28764","article-title":"Gain-of-function mutant of angiotensin II receptor, type 1A, causes hypertension and cardiovascular fibrosis in mice","volume":"117","author":"Billet","year":"2007","journal-title":"J Clin Invest"},{"issue":"11","key":"10.1016\/j.pharmthera.2010.04.005_bib41","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1038\/ki.2008.358","article-title":"Role of angiotensin II AT1 receptor activation in cardiovascular diseases","volume":"74","author":"Billet","year":"2008","journal-title":"Kidney Int"},{"issue":"5","key":"10.1016\/j.pharmthera.2010.04.005_bib42","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1006\/jmcc.2000.1123","article-title":"Myocardial-directed overexpression of the human beta(1)-adrenergic receptor in transgenic mice","volume":"32","author":"Bisognano","year":"2000","journal-title":"J Mol Cell Cardiol"},{"issue":"39","key":"10.1016\/j.pharmthera.2010.04.005_bib43","doi-asserted-by":"crossref","first-page":"14471","DOI":"10.1073\/pnas.0602543103","article-title":"Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure","volume":"103","author":"Bisping","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"18","key":"10.1016\/j.pharmthera.2010.04.005_bib44","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.ehj.2004.06.038","article-title":"Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure The Rotterdam Study","volume":"25","author":"Bleumink","year":"2004","journal-title":"Eur Heart J"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib45","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.jpainsymman.2007.06.007","article-title":"Symptom distress and quality of life in patients with advanced congestive heart failure","volume":"35","author":"Blinderman","year":"2008","journal-title":"J Pain Sympt Manage"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib46","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.pharmthera.2008.08.002","article-title":"The myocardial JAK\/STAT pathway: from protection to failure","volume":"120","author":"Boengler","year":"2008","journal-title":"Pharmacol Ther"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib47","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1161\/01.RES.79.2.162","article-title":"Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart. p38\/RK mitogen-activated protein kinases and c-Jun N-terminal kinases are activated by ischemia\/reperfusion","volume":"79","author":"Bogoyevitch","year":"1996","journal-title":"Circ Res"},{"issue":"10","key":"10.1016\/j.pharmthera.2010.04.005_bib48","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.1002\/pmic.200401356","article-title":"Changes in the rat heart proteome induced by exercise training: increased abundance of heat shock protein hsp20","volume":"6","author":"Boluyt","year":"2006","journal-title":"Proteomics"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib49","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1161\/CIRCRESAHA.107.169755","article-title":"Ca2+\/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure","volume":"102","author":"Bossuyt","year":"2008","journal-title":"Circ Res"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib50","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/0092-8674(91)90098-J","article-title":"ERKs: a family of protein\u2013serine\/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF","volume":"65","author":"Boulton","year":"1991","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.pharmthera.2010.04.005_bib51","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.jmb.2005.01.048","article-title":"The nuclear receptor coactivator PGC-1alpha exhibits modes of interaction with the estrogen receptor distinct from those of SRC-1","volume":"347","author":"Bourdoncle","year":"2005","journal-title":"J Mol Biol"},{"issue":"9","key":"10.1016\/j.pharmthera.2010.04.005_bib52","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1172\/JCI119755","article-title":"Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates","volume":"100","author":"Bowman","year":"1997","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib53","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1128\/MCB.25.3.1025-1040.2005","article-title":"Inhibition of macroautophagy triggers apoptosis","volume":"25","author":"Boya","year":"2005","journal-title":"Mol Cell Biol"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib54","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nm805","article-title":"Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload","volume":"9","author":"Brancaccio","year":"2003","journal-title":"Nat Med"},{"issue":"5","key":"10.1016\/j.pharmthera.2010.04.005_bib55","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1083\/jcb.200108062","article-title":"PKC alpha regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1\/2 (ERK1\/2)","volume":"156","author":"Braz","year":"2002","journal-title":"J Cell Biol"},{"issue":"10","key":"10.1016\/j.pharmthera.2010.04.005_bib56","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1172\/JCI200317295","article-title":"Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling","volume":"111","author":"Braz","year":"2003","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib57","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nm1000","article-title":"PKC-alpha regulates cardiac contractility and propensity toward heart failure","volume":"10","author":"Braz","year":"2004","journal-title":"Nat Med"},{"issue":"5","key":"10.1016\/j.pharmthera.2010.04.005_bib58","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1161\/01.CIR.101.5.558","article-title":"Beta-adrenergic receptor blockade in chronic heart failure","volume":"101","author":"Bristow","year":"2000","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.pharmthera.2010.04.005_bib59","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1161\/01.CIR.0000054530.87613.36","article-title":"Antiadrenergic therapy of chronic heart failure: surprises and new opportunities","volume":"107","author":"Bristow","year":"2003","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib60","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1056\/NEJM198207223070401","article-title":"Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts","volume":"307","author":"Bristow","year":"1982","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib61","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1006\/jmcc.1999.1065","article-title":"Myocardial fibrosis in transforming growth factor beta(1)heterozygous mice","volume":"32","author":"Brooks","year":"2000","journal-title":"J Mol Cell Cardiol"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib62","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.ejcts.2006.07.006","article-title":"The relationship between myocardial extracellular matrix remodeling and ventricular function","volume":"30","author":"Brower","year":"2006","journal-title":"Eur J Cardiothorac Surg"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib63","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.pharmthera.2005.11.001","article-title":"Cardiovascular endothelins: essential regulators of cardiovascular homeostasis","volume":"111","author":"Brunner","year":"2006","journal-title":"Pharmacol Ther"},{"issue":"23","key":"10.1016\/j.pharmthera.2010.04.005_bib64","doi-asserted-by":"crossref","first-page":"6341","DOI":"10.1093\/emboj\/19.23.6341","article-title":"The MEK1-ERK1\/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice","volume":"19","author":"Bueno","year":"2000","journal-title":"EMBO J"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib65","doi-asserted-by":"crossref","first-page":"4586","DOI":"10.1073\/pnas.072647999","article-title":"Impaired cardiac hypertrophic response in Calcineurin Abeta-deficient mice","volume":"99","author":"Bueno","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1016\/j.pharmthera.2010.04.005_bib66","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.cardfail.2006.03.002","article-title":"Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase","volume":"12","author":"Buerger","year":"2006","journal-title":"J Card Fail"},{"issue":"8","key":"10.1016\/j.pharmthera.2010.04.005_bib67","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nm1272","article-title":"The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy","volume":"11","author":"Buitrago","year":"2005","journal-title":"Nat Med"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib68","doi-asserted-by":"crossref","first-page":"H1055","DOI":"10.1152\/ajpheart.00925.2003","article-title":"Regular exercise is associated with a protective metabolic phenotype in the rat heart","volume":"287","author":"Burelle","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib69","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/pmic.200800268","article-title":"Adaptation of the rat cardiac proteome in response to intensity-controlled endurance exercise","volume":"9","author":"Burniston","year":"2009","journal-title":"Proteomics"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib70","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1517\/14728220902939161","article-title":"Targeting histone deacetylases for heart failure","volume":"13","author":"Bush","year":"2009","journal-title":"Expert Opin Ther Targets"},{"issue":"9","key":"10.1016\/j.pharmthera.2010.04.005_bib71","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1172\/JCI36154","article-title":"MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice","volume":"119","author":"Callis","year":"2009","journal-title":"J Clin Invest"},{"issue":"5573","key":"10.1016\/j.pharmthera.2010.04.005_bib72","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1126\/science.296.5573.1655","article-title":"The phosphoinositide 3-kinase pathway","volume":"296","author":"Cantley","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib73","series-title":"An NHLBI Sponsored Program for Genomic Applications","year":"2001"},{"issue":"5","key":"10.1016\/j.pharmthera.2010.04.005_bib74","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nm1582","article-title":"MicroRNA-133 controls cardiac hypertrophy","volume":"13","author":"Care","year":"2007","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib75","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.bbalip.2005.03.005","article-title":"Fatty acid metabolism is enhanced in type 2 diabetic hearts","volume":"1734","author":"Carley","year":"2005","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib76","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1161\/01.CIR.86.4.1099","article-title":"Sex-associated differences in left ventricular function in aortic stenosis of the elderly","volume":"86","author":"Carroll","year":"1992","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib77","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1161\/CIRCGENETICS.109.857425","article-title":"MicroRNAs in cardiovascular biology and heart disease","volume":"2","author":"Catalucci","year":"2009","journal-title":"Circ Cardiovasc Genet"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib78","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.pupt.2005.04.005","article-title":"Tackling the EGFR in pathological tissue remodelling","volume":"19","author":"Chan","year":"2006","journal-title":"Pulm Pharmacol Ther"},{"issue":"19","key":"10.1016\/j.pharmthera.2010.04.005_bib79","doi-asserted-by":"crossref","first-page":"8467","DOI":"10.1128\/MCB.24.19.8467-8476.2004","article-title":"Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development","volume":"24","author":"Chang","year":"2004","journal-title":"Mol Cell Biol"},{"issue":"20","key":"10.1016\/j.pharmthera.2010.04.005_bib80","doi-asserted-by":"crossref","first-page":"11114","DOI":"10.1073\/pnas.191369098","article-title":"Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC","volume":"98","author":"Chen","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"10.1016\/j.pharmthera.2010.04.005_bib81","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1021\/cr000241p","article-title":"MAP kinases","volume":"101","author":"Chen","year":"2001","journal-title":"Chem Rev"},{"issue":"12","key":"10.1016\/j.pharmthera.2010.04.005_bib82","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1161\/01.RES.87.12.1172","article-title":"The beta(2)-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3\u2032-kinase","volume":"87","author":"Chesley","year":"2000","journal-title":"Circ Res"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib83","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1161\/01.RES.88.6.546","article-title":"To Cre or not to Cre: the next generation of mouse models of human cardiac diseases","volume":"88","author":"Chien","year":"2001","journal-title":"Circ Res"},{"issue":"15","key":"10.1016\/j.pharmthera.2010.04.005_bib84","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1096\/fasebj.5.15.1835945","article-title":"Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response","volume":"5","author":"Chien","year":"1991","journal-title":"FASEB J"},{"issue":"28","key":"10.1016\/j.pharmthera.2010.04.005_bib85","doi-asserted-by":"crossref","first-page":"19762","DOI":"10.1074\/jbc.274.28.19762","article-title":"Regulation of Ras.GTP loading and Ras-Raf association in neonatal rat ventricular myocytes by G protein-coupled receptor agonists and phorbol ester. Activation of the extracellular signal-regulated kinase cascade by phorbol ester is mediated by Ras","volume":"274","author":"Chiloeches","year":"1999","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib86","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1136\/hrt.75.4.363","article-title":"Cardiac hypertrophy as a result of long-term thyroxine therapy and thyrotoxicosis","volume":"75","author":"Ching","year":"1996","journal-title":"Heart"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib87","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1172\/JCI10947","article-title":"A novel mouse model of lipotoxic cardiomyopathy","volume":"107","author":"Chiu","year":"2001","journal-title":"J Clin Invest"},{"issue":"42","key":"10.1016\/j.pharmthera.2010.04.005_bib88","doi-asserted-by":"crossref","first-page":"38349","DOI":"10.1074\/jbc.C100462200","article-title":"Akt1\/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice","volume":"276","author":"Cho","year":"2001","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib89","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1172\/JCI3512","article-title":"Role of the stress-activated protein kinases in endothelin-induced cardiomyocyte hypertrophy","volume":"102","author":"Choukroun","year":"1998","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib90","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1172\/JCI6350","article-title":"Regulation of cardiac hypertrophy in vivo by the stress-activated protein kinases\/c-Jun NH(2)-terminal kinases","volume":"104","author":"Choukroun","year":"1999","journal-title":"J Clin Invest"},{"issue":"10","key":"10.1016\/j.pharmthera.2010.04.005_bib91","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1006\/jmcc.1994.1155","article-title":"Altered glucose and fatty acid oxidation in hearts of the spontaneously hypertensive rat","volume":"26","author":"Christe","year":"1994","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib92","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev.ph.45.030183.001035","article-title":"Sympathetic nervous activity during exercise","volume":"45","author":"Christensen","year":"1983","journal-title":"Annu Rev Physiol"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib93","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1161\/01.RES.0000107198.90218.21","article-title":"Phosphoproteome analysis of cardiomyocytes subjected to {beta}-adrenergic stimulation: identification and characterization of a cardiac heat shock protein p20","volume":"94","author":"Chu","year":"2004","journal-title":"Circ Res"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib94","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.pharmthera.2007.06.013","article-title":"Potential of p38-MAPK inhibitors in the treatment of ischaemic heart disease","volume":"116","author":"Clark","year":"2007","journal-title":"Pharmacol Ther"},{"issue":"12A","key":"10.1016\/j.pharmthera.2010.04.005_bib95","doi-asserted-by":"crossref","first-page":"64H","DOI":"10.1016\/S0002-9149(99)00261-1","article-title":"Activation of protein kinase cascades in the heart by hypertrophic G protein-coupled receptor agonists","volume":"83","author":"Clerk","year":"1999","journal-title":"Am J Cardiol"},{"issue":"10","key":"10.1016\/j.pharmthera.2010.04.005_bib96","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1161\/01.RES.86.10.1019","article-title":"Small guanine nucleotide-binding proteins and myocardial hypertrophy","volume":"86","author":"Clerk","year":"2000","journal-title":"Circ Res"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib97","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1128\/MCB.21.4.1173-1184.2001","article-title":"Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1","volume":"21","author":"Clerk","year":"2001","journal-title":"Mol Cell Biol"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib98","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.cellsig.2005.04.005","article-title":"Peptide growth factors signal differentially through protein kinase C to extracellular signal-regulated kinases in neonatal cardiomyocytes","volume":"18","author":"Clerk","year":"2006","journal-title":"Cell Signal"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib99","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/CVM-1-3-155","article-title":"Exercise training in heart failure","volume":"1","author":"Coats","year":"2000","journal-title":"Curr Control Trials Cardiovasc Med"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib100","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1161\/01.CIR.95.4.766","article-title":"Report of the national heart, lung, and blood institute special emphasis panel on heart failure research","volume":"95","author":"Cohn","year":"1997","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib101","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1365-2265.2008.03292.x","article-title":"The GH-IGF-I axis and the cardiovascular system: clinical implications","volume":"69","author":"Colao","year":"2008","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib102","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1046\/j.1365-2265.2001.01218.x","article-title":"Growth hormone and the heart","volume":"54","author":"Colao","year":"2001","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"8","key":"10.1016\/j.pharmthera.2010.04.005_bib103","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1210\/jc.87.8.3650","article-title":"The cardiovascular risk of GH-deficient adolescents","volume":"87","author":"Colao","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"issue":"19","key":"10.1016\/j.pharmthera.2010.04.005_bib104","doi-asserted-by":"crossref","first-page":"12333","DOI":"10.1073\/pnas.172376399","article-title":"Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice","volume":"99","author":"Condorelli","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib105","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0092-8674(00)80563-2","article-title":"Size control in animal development","volume":"96","author":"Conlon","year":"1999","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.pharmthera.2010.04.005_bib106","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1006\/jmcc.1999.0979","article-title":"Activation of c-Jun N-terminal kinases and p38-mitogen-activated protein kinases in human heart failure secondary to ischaemic heart disease","volume":"31","author":"Cook","year":"1999","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib107","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1146\/annurev.ph.49.030187.002441","article-title":"Cardiocyte adaptation to chronically altered load","volume":"49","author":"Cooper","year":"1987","journal-title":"Annu Rev Physiol"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib108","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1161\/CIRCRESAHA.108.192872","article-title":"MicroRNA regulation of cardiovascular development","volume":"104","author":"Cordes","year":"2009","journal-title":"Circ Res"},{"issue":"5","key":"10.1016\/j.pharmthera.2010.04.005_bib109","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1136\/heart.83.5.505","article-title":"Survival of patients with a new diagnosis of heart failure: a population based study","volume":"83","author":"Cowie","year":"2000","journal-title":"Heart"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib110","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0092-8674(02)00969-8","article-title":"Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways","volume":"110","author":"Crackower","year":"2002","journal-title":"Cell"},{"issue":"15","key":"10.1016\/j.pharmthera.2010.04.005_bib111","doi-asserted-by":"crossref","first-page":"8121","DOI":"10.1073\/pnas.94.15.8121","article-title":"Transgenic Galphaq overexpression induces cardiac contractile failure in mice","volume":"94","author":"D'Angelo","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib112","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1089\/105072502760143836","article-title":"Thyroid hormone-regulated cardiac gene expression and cardiovascular disease","volume":"12","author":"Danzi","year":"2002","journal-title":"Thyroid"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib113","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/S0008-6363(02)00772-1","article-title":"Differential regulation of p38 mitogen-activated protein kinase mediates gender-dependent catecholamine-induced hypertrophy","volume":"57","author":"Dash","year":"2003","journal-title":"Cardiovasc Res"},{"issue":"9280","key":"10.1016\/j.pharmthera.2010.04.005_bib114","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0140-6736(01)05620-3","article-title":"Prevalence of left-ventricular systolic dysfunction and heart failure in the Echocardiographic Heart of England Screening study: a population based study","volume":"358","author":"Davies","year":"2001","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib115","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0735-1097(02)01967-8","article-title":"Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy","volume":"40","author":"Davila-Roman","year":"2002","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"10.1016\/j.pharmthera.2010.04.005_bib116","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1161\/01.RES.0000168028.36081.e0","article-title":"Cardiac overexpression of melusin protects from dilated cardiomyopathy due to long-standing pressure overload","volume":"96","author":"De Acetis","year":"2005","journal-title":"Circ Res"},{"issue":"5","key":"10.1016\/j.pharmthera.2010.04.005_bib117","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1161\/01.HYP.25.5.924","article-title":"Proposed update of angiotensin receptor nomenclature","volume":"25","author":"de Gasparo","year":"1995","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib118","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0031-6997(24)01458-3","article-title":"International union of pharmacology. XXIII. The angiotensin II receptors","volume":"52","author":"de Gasparo","year":"2000","journal-title":"Pharmacol Rev"},{"issue":"30","key":"10.1016\/j.pharmthera.2010.04.005_bib119","doi-asserted-by":"crossref","first-page":"27873","DOI":"10.1074\/jbc.M010984200","article-title":"Mechanisms of estrogen receptor action in the myocardium. Rapid gene activation via the ERK1\/2 pathway and serum response elements","volume":"276","author":"de Jager","year":"2001","journal-title":"J Biol Chem"},{"issue":"6 Pt 1","key":"10.1016\/j.pharmthera.2010.04.005_bib120","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1161\/01.HYP.26.6.979","article-title":"Gender differences in left ventricular growth","volume":"26","author":"de Simone","year":"1995","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib121","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1161\/01.RES.86.3.255","article-title":"Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: an apoptosis-independent model of dilated heart failure","volume":"86","author":"De Windt","year":"2000","journal-title":"Circ Res"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib122","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1073\/pnas.031371998","article-title":"Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo","volume":"98","author":"De Windt","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"43","key":"10.1016\/j.pharmthera.2010.04.005_bib123","doi-asserted-by":"crossref","first-page":"32841","DOI":"10.1074\/jbc.M513087200","article-title":"Akt2 regulates cardiac metabolism and cardiomyocyte survival","volume":"281","author":"DeBosch","year":"2006","journal-title":"J Biol Chem"},{"issue":"17","key":"10.1016\/j.pharmthera.2010.04.005_bib124","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1161\/CIRCULATIONAHA.105.595231","article-title":"Akt1 is required for physiological cardiac growth","volume":"113","author":"DeBosch","year":"2006","journal-title":"Circulation"},{"issue":"14","key":"10.1016\/j.pharmthera.2010.04.005_bib125","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1096\/fasebj.13.14.1923","article-title":"Local insulin-like growth factor I expression induces physiologic, then pathologic, cardiac hypertrophy in transgenic mice","volume":"13","author":"Delaughter","year":"1999","journal-title":"FASEB J"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib126","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1172\/JCI27987","article-title":"Estrogen receptors and human disease","volume":"116","author":"Deroo","year":"2006","journal-title":"J Clin Invest"},{"issue":"1 Pt 2","key":"10.1016\/j.pharmthera.2010.04.005_bib127","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1067\/mhj.2000.102902","article-title":"Therapeutic options in minimizing left ventricular hypertrophy","volume":"139","author":"Devereux","year":"2000","journal-title":"Am Heart J"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib128","doi-asserted-by":"crossref","first-page":"H830","DOI":"10.1152\/ajpheart.00761.2002","article-title":"Microarray expression analysis of effects of exercise training: increase in atrial MLC-1 in rat ventricles","volume":"284","author":"Diffee","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib129","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1089\/105072502760143809","article-title":"Cellular action of thyroid hormone on the heart","volume":"12","author":"Dillmann","year":"2002","journal-title":"Thyroid"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib130","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.cardiores.2007.06.027","article-title":"Cardiac peroxisome proliferator-activated receptor gamma is essential in protecting cardiomyocytes from oxidative damage","volume":"76","author":"Ding","year":"2007","journal-title":"Cardiovasc Res"},{"issue":"10","key":"10.1016\/j.pharmthera.2010.04.005_bib131","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1161\/CIRCRESAHA.108.183087","article-title":"The emerging role of microRNAs in cardiac remodeling and heart failure","volume":"103","author":"Divakaran","year":"2008","journal-title":"Circ Res"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib132","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1161\/CIRCRESAHA.108.190397","article-title":"Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradation","volume":"104","author":"Donaldson","year":"2009","journal-title":"Circ Res"},{"issue":"5","key":"10.1016\/j.pharmthera.2010.04.005_bib133","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1161\/HYPERTENSIONAHA.106.079426","article-title":"The fuzzy logic of physiological cardiac hypertrophy","volume":"49","author":"Dorn","year":"2007","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib134","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1172\/JCI24178","article-title":"Protein kinase cascades in the regulation of cardiac hypertrophy","volume":"115","author":"Dorn","year":"2005","journal-title":"J Clin Invest"},{"issue":"1 Pt 2","key":"10.1016\/j.pharmthera.2010.04.005_bib135","first-page":"H400","article-title":"Myosin heavy chain regulation and myocyte contractile depression after LV hypertrophy in aortic-banded mice","volume":"267","author":"Dorn","year":"1994","journal-title":"Am J Physiol"},{"issue":"11","key":"10.1016\/j.pharmthera.2010.04.005_bib136","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1161\/01.RES.0000077012.11088.BC","article-title":"Phenotyping hypertrophy: eschew obfuscation","volume":"92","author":"Dorn","year":"2003","journal-title":"Circ Res"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib137","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1136\/hrt.73.6.548","article-title":"Gender differences in left ventricle geometry and function in patients undergoing balloon dilatation of the aortic valve for isolated aortic stenosis. NHLBI Balloon Valvuloplasty Registry","volume":"73","author":"Douglas","year":"1995","journal-title":"Br Heart J"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib138","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/S0735-1097(98)00347-7","article-title":"Hypertrophic remodeling: gender differences in the early response to left ventricular pressure overload","volume":"32","author":"Douglas","year":"1998","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib139","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1440-1681.2007.04871.x","article-title":"Distinct role of adrenoceptor subtypes in cardiac adaptation to chronic pressure overload","volume":"35","author":"Du","year":"2008","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib140","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.pharmthera.2005.10.016","article-title":"Sex dimorphism in cardiac pathophysiology: experimental findings, hormonal mechanisms, and molecular mechanisms","volume":"111","author":"Du","year":"2006","journal-title":"Pharmacol Ther"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib141","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0167-4889(94)90221-6","article-title":"Identification and characterization of delta B-CaM kinase and delta C-CaM kinase from rat heart, two new multifunctional Ca2+\/calmodulin-dependent protein kinase isoforms","volume":"1221","author":"Edman","year":"1994","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib142","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev.physiol.67.040403.120151","article-title":"Regulation of signal transduction pathways by estrogen and progesterone","volume":"67","author":"Edwards","year":"2005","journal-title":"Annu Rev Physiol"},{"issue":"11","key":"10.1016\/j.pharmthera.2010.04.005_bib143","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1161\/01.RES.0000170652.71414.16","article-title":"Molecular and functional signature of heart hypertrophy during pregnancy","volume":"96","author":"Eghbali","year":"2005","journal-title":"Circ Res"},{"issue":"8","key":"10.1016\/j.pharmthera.2010.04.005_bib144","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.tcm.2006.07.001","article-title":"Heart hypertrophy during pregnancy: a better functioning heart?","volume":"16","author":"Eghbali","year":"2006","journal-title":"Trends Cardiovasc Med"},{"issue":"12","key":"10.1016\/j.pharmthera.2010.04.005_bib145","doi-asserted-by":"crossref","first-page":"7059","DOI":"10.1073\/pnas.96.12.7059","article-title":"Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice","volume":"96","author":"Engelhardt","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"10.1016\/j.pharmthera.2010.04.005_bib146","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1161\/01.CIR.103.10.1453","article-title":"Cardiac overexpression of a G(q) inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase activity in in vivo pressure overload","volume":"103","author":"Esposito","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib147","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s12551-008-0007-y","article-title":"Intercalated discs: multiple proteins perform multiple functions in non-failing and failing human hearts","volume":"1","author":"Estigoy","year":"2009","journal-title":"Biophys Rev"},{"issue":"6 Pt 1","key":"10.1016\/j.pharmthera.2010.04.005_bib148","first-page":"E633","article-title":"Mechanisms involved in alpha-adrenergic phenomena","volume":"248","author":"Exton","year":"1985","journal-title":"Am J Physiol"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib149","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0733-8651(05)70348-9","article-title":"Impact of different sports and training on cardiac structure and function","volume":"15","author":"Fagard","year":"1997","journal-title":"Cardiol Clin"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib150","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.tcm.2005.05.004","article-title":"Hsp20 and its cardioprotection","volume":"15","author":"Fan","year":"2005","journal-title":"Trends Cardiovasc Med"},{"issue":"48","key":"10.1016\/j.pharmthera.2010.04.005_bib152","doi-asserted-by":"crossref","first-page":"40337","DOI":"10.1074\/jbc.M506810200","article-title":"A transgenic mouse model of heart failure using inducible Galpha q","volume":"280","author":"Fan","year":"2005","journal-title":"J Biol Chem"},{"issue":"11","key":"10.1016\/j.pharmthera.2010.04.005_bib153","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1161\/01.RES.0000251074.19348.af","article-title":"Small heat-shock protein Hsp20 attenuates {beta}-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase 1","volume":"99","author":"Fan","year":"2006","journal-title":"Circ Res"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib154","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1124\/jpet.103.055038","article-title":"Steroid hormone interactions with target cells: cross talk between membrane and nuclear pathways","volume":"307","author":"Farach-Carson","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"issue":"5","key":"10.1016\/j.pharmthera.2010.04.005_bib155","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/S0735-1097(86)80213-3","article-title":"Myocardial mechanics in hyperthyroidism: importance of left ventricular loading conditions, heart rate and contractile state","volume":"7","author":"Feldman","year":"1986","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib156","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1006\/dbio.2000.9816","article-title":"GSK-3: new thoughts on an old enzyme","volume":"225","author":"Ferkey","year":"2000","journal-title":"Dev Biol"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib157","series-title":"Growth of the Heart in Health and Disease","first-page":"187","article-title":"Cardiac hypertrophy: morphological aspects","author":"Ferrans","year":"1984"},{"issue":"8","key":"10.1016\/j.pharmthera.2010.04.005_bib158","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1073\/pnas.0712265105","article-title":"Requirement of protein kinase D1 for pathological cardiac remodeling","volume":"105","author":"Fielitz","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib159","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1073\/pnas.0336724100","article-title":"A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content","volume":"100","author":"Finck","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib160","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1096\/fj.02-0289fje","article-title":"Persistent IGF-I overexpression in skeletal muscle transiently enhances DNA accretion and growth","volume":"17","author":"Fiorotto","year":"2003","journal-title":"FASEB J"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib161","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00395-007-0658-z","article-title":"Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis","volume":"102","author":"Fischer","year":"2007","journal-title":"Basic Res Cardiol"},{"issue":"Suppl 1","key":"10.1016\/j.pharmthera.2010.04.005_bib162","doi-asserted-by":"crossref","first-page":"S414","DOI":"10.1038\/bjp.2008.1","article-title":"Role of gp130-mediated signalling pathways in the heart and its impact on potential therapeutic aspects","volume":"153","author":"Fischer","year":"2008","journal-title":"Br J Pharmacol"},{"issue":"14","key":"10.1016\/j.pharmthera.2010.04.005_bib163","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1001\/jama.2009.457","article-title":"Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial","volume":"301","author":"Flynn","year":"2009","journal-title":"JAMA"},{"issue":"19","key":"10.1016\/j.pharmthera.2010.04.005_bib164","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1056\/NEJM198211043071901","article-title":"Abnormal left ventricular function in hyperthyroidism: evidence for a possible reversible cardiomyopathy","volume":"307","author":"Forfar","year":"1982","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib165","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.physiol.65.092101.142243","article-title":"Cardiac hypertrophy: the good, the bad, and the ugly","volume":"65","author":"Frey","year":"2003","journal-title":"Annu Rev Physiol"},{"issue":"11","key":"10.1016\/j.pharmthera.2010.04.005_bib166","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/81321","article-title":"Decoding calcium signals involved in cardiac growth and function","volume":"6","author":"Frey","year":"2000","journal-title":"Nat Med"},{"issue":"12","key":"10.1016\/j.pharmthera.2010.04.005_bib167","doi-asserted-by":"crossref","first-page":"6745","DOI":"10.1073\/pnas.100127897","article-title":"Expression profiling reveals distinct sets of genes altered during induction and regression of cardiac hypertrophy","volume":"97","author":"Friddle","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib168","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.yjmcc.2004.11.013","article-title":"Estrogen receptor beta mediates gender differences in ischemia\/reperfusion injury","volume":"38","author":"Gabel","year":"2005","journal-title":"J Mol Cell Cardiol"},{"issue":"9","key":"10.1016\/j.pharmthera.2010.04.005_bib169","doi-asserted-by":"crossref","first-page":"4097","DOI":"10.1210\/en.2002-0214","article-title":"Sex hormones and cardiomyopathic phenotype induced by cardiac beta 2-adrenergic receptor overexpression","volume":"144","author":"Gao","year":"2003","journal-title":"Endocrinology"},{"issue":"12","key":"10.1016\/j.pharmthera.2010.04.005_bib170","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1093\/oxfordjournals.eurheartj.a059434","article-title":"Sex differences in cardiac adaptation to essential hypertension","volume":"10","author":"Garavaglia","year":"1989","journal-title":"Eur Heart J"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib171","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0188-0128(99)00059-7","article-title":"Alpha 1-adrenoceptors: subtypes, signaling, and roles in health and disease","volume":"30","author":"Garcia-Sainz","year":"1999","journal-title":"Arch Med Res"},{"issue":"8","key":"10.1016\/j.pharmthera.2010.04.005_bib172","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1096\/fj.08-108316","article-title":"Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptors","volume":"22","author":"Gembardt","year":"2008","journal-title":"FASEB J"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib173","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1161\/01.RES.84.1.34","article-title":"Apoptosis of cardiac myocytes in Gsalpha transgenic mice","volume":"84","author":"Geng","year":"1999","journal-title":"Circ Res"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib174","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1172\/JCI113822","article-title":"Myocardial substrate utilization during exercise in humans. Dual carbon-labeled carbohydrate isotope experiments","volume":"82","author":"Gertz","year":"1988","journal-title":"J Clin Invest"},{"issue":"5","key":"10.1016\/j.pharmthera.2010.04.005_bib175","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.jacc.2009.02.078","article-title":"Palliative care in congestive heart failure","volume":"54","author":"Goodlin","year":"2009","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib176","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1249\/01.mss.0000205138.02440.79","article-title":"Disparate regulation of signaling proteins after exercise and myocardial infarction","volume":"38","author":"Gosselin","year":"2006","journal-title":"Med Sci Sports Exerc"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib177","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00395-009-0011-9","article-title":"Cardioprotection requires taking out the trash","volume":"104","author":"Gottlieb","year":"2009","journal-title":"Basic Res Cardiol"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib178","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000175770","article-title":"Influence of age and sex on left ventricular anatomy and function in normals","volume":"81","author":"Grandi","year":"1992","journal-title":"Cardiology"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib179","doi-asserted-by":"crossref","first-page":"D140","DOI":"10.1093\/nar\/gkj112","article-title":"miRBase: microRNA sequences, targets and gene nomenclature","volume":"34","author":"Griffiths-Jones","year":"2006","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib180","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1172\/JCI108079","article-title":"Wall stress and patterns of hypertrophy in the human left ventricle","volume":"56","author":"Grossman","year":"1975","journal-title":"J Clin Invest"},{"issue":"9","key":"10.1016\/j.pharmthera.2010.04.005_bib181","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1161\/01.RES.85.9.856","article-title":"Myocyte death in the failing human heart is gender dependent","volume":"85","author":"Guerra","year":"1999","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib182","series-title":"Role of the Cardiac Interstitium","first-page":"57","article-title":"Myocardial basis for heart failure","author":"Gunasinghe","year":"2004"},{"issue":"15","key":"10.1016\/j.pharmthera.2010.04.005_bib183","doi-asserted-by":"crossref","first-page":"10135","DOI":"10.1074\/jbc.M710277200","article-title":"HDAC4 and PCAF bind to cardiac sarcomeres and play a role in regulating myofilament contractile activity","volume":"283","author":"Gupta","year":"2008","journal-title":"J Biol Chem"},{"issue":"11 Reviews","key":"10.1016\/j.pharmthera.2010.04.005_bib184","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/sj.onc.1202186","article-title":"Cell growth control by G protein-coupled receptors: from signal transduction to signal integration","volume":"17","author":"Gutkind","year":"1998","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib185","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1074\/jbc.273.4.1839","article-title":"The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades","volume":"273","author":"Gutkind","year":"1998","journal-title":"J Biol Chem"},{"issue":"11","key":"10.1016\/j.pharmthera.2010.04.005_bib186","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1161\/01.RES.0000105087.79373.17","article-title":"Protein kinase Calpha negatively regulates systolic and diastolic function in pathological hypertrophy","volume":"93","author":"Hahn","year":"2003","journal-title":"Circ Res"},{"issue":"3 Pt 2","key":"10.1016\/j.pharmthera.2010.04.005_bib187","first-page":"H868","article-title":"Pressure-overload hypertrophy is unabated in mice devoid of AT1A receptors","volume":"274","author":"Hamawaki","year":"1998","journal-title":"Am J Physiol"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib188","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/cvr\/cvm079","article-title":"Sarcomeric dysfunction in heart failure","volume":"77","author":"Hamdani","year":"2008","journal-title":"Cardiovasc Res"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib189","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1083\/jcb.151.1.117","article-title":"Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy","volume":"151","author":"Haq","year":"2000","journal-title":"J Cell Biol"},{"issue":"5","key":"10.1016\/j.pharmthera.2010.04.005_bib190","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1161\/01.CIR.103.5.670","article-title":"Differential activation of signal transduction pathways in human hearts with hypertrophy versus advanced heart failure","volume":"103","author":"Haq","year":"2001","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib191","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1161\/01.RES.82.7.779","article-title":"Acute pressure overload could induce hypertrophic responses in the heart of angiotensin II type 1a knockout mice","volume":"82","author":"Harada","year":"1998","journal-title":"Circ Res"},{"issue":"10","key":"10.1016\/j.pharmthera.2010.04.005_bib192","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1161\/01.RES.0000018952.70505.F1","article-title":"Glycogen synthase kinase-3beta: a novel regulator of cardiac hypertrophy and development","volume":"90","author":"Hardt","year":"2002","journal-title":"Circ Res"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib193","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1161\/01.CIR.0000138190.50127.6A","article-title":"Raf-1 kinase is required for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload","volume":"110","author":"Harris","year":"2004","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.pharmthera.2010.04.005_bib194","doi-asserted-by":"crossref","first-page":"3875","DOI":"10.1128\/MCB.26.10.3875-3888.2006","article-title":"Regulation of cardiac stress signaling by protein kinase d1","volume":"26","author":"Harrison","year":"2006","journal-title":"Mol Cell Biol"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib195","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1089\/105072502760143791","article-title":"Mechanism of thyroid hormone action","volume":"12","author":"Harvey","year":"2002","journal-title":"Thyroid"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib196","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0092-8674(01)00412-3","article-title":"Regulation of GSK-3: a cellular multiprocessor","volume":"105","author":"Harwood","year":"2001","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.pharmthera.2010.04.005_bib197","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1161\/01.RES.82.11.1111","article-title":"Apoptosis: basic mechanisms and implications for cardiovascular disease","volume":"82","author":"Haunstetter","year":"1998","journal-title":"Circ Res"},{"issue":"24","key":"10.1016\/j.pharmthera.2010.04.005_bib198","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1161\/01.CIR.0000101920.72665.58","article-title":"Inhibition of cardiac myocyte apoptosis improves cardiac function and abolishes mortality in the peripartum cardiomyopathy of Galpha(q) transgenic mice","volume":"108","author":"Hayakawa","year":"2003","journal-title":"Circulation"},{"issue":"6551","key":"10.1016\/j.pharmthera.2010.04.005_bib199","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/377744a0","article-title":"Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice","volume":"377","author":"Hein","year":"1995","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib200","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0008-6363(99)00268-0","article-title":"The role of the cytoskeleton in heart failure","volume":"45","author":"Hein","year":"2000","journal-title":"Cardiovasc Res"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib201","doi-asserted-by":"crossref","first-page":"385","DOI":"10.7150\/ijbs.3.385","article-title":"Reversal of systemic hypertension-associated cardiac remodeling in chronic pressure overload myocardium by ciglitazone","volume":"3","author":"Henderson","year":"2007","journal-title":"Int J Biol Sci"},{"issue":"12","key":"10.1016\/j.pharmthera.2010.04.005_bib202","doi-asserted-by":"crossref","first-page":"10251","DOI":"10.1074\/jbc.M110722200","article-title":"Targeted inhibition of calcineurin in pressure-overload cardiac hypertrophy. Preservation of systolic function","volume":"277","author":"Hill","year":"2002","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib203","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0092-8674(00)80729-1","article-title":"Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress","volume":"97","author":"Hirota","year":"1999","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib204","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1161\/01.RES.84.6.713","article-title":"Identification and expression of delta-isoforms of the multifunctional Ca2+\/calmodulin-dependent protein kinase in failing and nonfailing human myocardium","volume":"84","author":"Hoch","year":"1999","journal-title":"Circ Res"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib205","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.yjmcc.2008.04.008","article-title":"Tamoxifen-inducible gene deletion in the cardiac conduction system","volume":"45","author":"Hoesl","year":"2008","journal-title":"J Mol Cell Cardiol"},{"issue":"1\u20133","key":"10.1016\/j.pharmthera.2010.04.005_bib206","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0014-5793(93)81805-A","article-title":"Cardiac hypertrophy in juvenile visceral steatosis (jvs) mice with systemic carnitine deficiency","volume":"326","author":"Horiuchi","year":"1993","journal-title":"FEBS Lett"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib207","doi-asserted-by":"crossref","first-page":"H1313","DOI":"10.1152\/ajpheart.00816.2005","article-title":"Mechanical stress\u2013strain sensors embedded in cardiac cytoskeleton: Z disk, titin, and associated structures","volume":"290","author":"Hoshijima","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"13","key":"10.1016\/j.pharmthera.2010.04.005_bib208","doi-asserted-by":"crossref","first-page":"7725","DOI":"10.1074\/jbc.273.13.7725","article-title":"The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes. Involvement of Rho kinase","volume":"273","author":"Hoshijima","year":"1998","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib209","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1159\/000159155","article-title":"Postnatal growth of the heart and its blood vessels","volume":"33","author":"Hudlicka","year":"1996","journal-title":"J Vasc Res"},{"issue":"14","key":"10.1016\/j.pharmthera.2010.04.005_bib210","doi-asserted-by":"crossref","first-page":"e391","DOI":"10.1161\/CIRCULATIONAHA.109.192065","article-title":"2009 focused update incorporated into the ACC\/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation","volume":"119","author":"Hunt","year":"2009","journal-title":"Circulation"},{"issue":"17","key":"10.1016\/j.pharmthera.2010.04.005_bib211","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1056\/NEJM199910213411706","article-title":"Signaling pathways for cardiac hypertrophy and failure","volume":"341","author":"Hunter","year":"1999","journal-title":"N Engl J Med"},{"issue":"39","key":"10.1016\/j.pharmthera.2010.04.005_bib212","doi-asserted-by":"crossref","first-page":"23173","DOI":"10.1074\/jbc.270.39.23173","article-title":"Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice","volume":"270","author":"Hunter","year":"1995","journal-title":"J Biol Chem"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib213","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.2337\/db09-1456","article-title":"Cardiac-specific IGF-1 receptor transgenic expression protects against cardiac fibrosis and diastolic dysfunction in a mouse model of diabetic cardiomyopathy","volume":"59","author":"Huynh","year":"2010","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib214","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/geno.2000.6171","article-title":"Identification of differentially expressed genes in cardiac hypertrophy by analysis of expressed sequence tags","volume":"66","author":"Hwang","year":"2000","journal-title":"Genomics"},{"issue":"9","key":"10.1016\/j.pharmthera.2010.04.005_bib215","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1093\/bioinformatics\/18.9.1184","article-title":"Determination of minimum sample size and discriminatory expression patterns in microarray data","volume":"18","author":"Hwang","year":"2002","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib216","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1152\/physiolgenomics.00122.2001","article-title":"Microarray gene expression profiles in dilated and hypertrophic cardiomyopathic end-stage heart failure","volume":"10","author":"Hwang","year":"2002","journal-title":"Physiol Genomics"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib217","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.yjmcc.2006.05.013","article-title":"Attenuation of cardiac dysfunction by a PPAR-alpha agonist is associated with down-regulation of redox-regulated transcription factors","volume":"41","author":"Ichihara","year":"2006","journal-title":"J Mol Cell Cardiol"},{"issue":"6551","key":"10.1016\/j.pharmthera.2010.04.005_bib218","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/377748a0","article-title":"Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor","volume":"377","author":"Ichiki","year":"1995","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib219","doi-asserted-by":"crossref","first-page":"R2029","DOI":"10.1152\/ajpregu.2001.281.6.R2029","article-title":"Physiological and pathological cardiac hypertrophy induce different molecular phenotypes in the rat","volume":"281","author":"Iemitsu","year":"2001","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"10","key":"10.1016\/j.pharmthera.2010.04.005_bib220","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1291\/hypres.26.829","article-title":"Cardiac hypertrophy by hypertension and exercise training exhibits different gene expression of enzymes in energy metabolism","volume":"26","author":"Iemitsu","year":"2003","journal-title":"Hypertens Res"},{"issue":"33","key":"10.1016\/j.pharmthera.2010.04.005_bib221","doi-asserted-by":"crossref","first-page":"29661","DOI":"10.1074\/jbc.M411694200","article-title":"Androgen receptor gene knockout male mice exhibit impaired cardiac growth and exacerbation of angiotensin II-induced cardiac fibrosis","volume":"280","author":"Ikeda","year":"2005","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib222","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1152\/physiolgenomics.00144.2007","article-title":"Altered microRNA expression in human heart disease","volume":"31","author":"Ikeda","year":"2007","journal-title":"Physiol Genomics"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib223","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1172\/JCI116579","article-title":"Endothelin-1 is an autocrine\/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes","volume":"92","author":"Ito","year":"1993","journal-title":"J Clin Invest"},{"issue":"4738","key":"10.1016\/j.pharmthera.2010.04.005_bib224","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1126\/science.3945800","article-title":"All members of the MHC multigene family respond to thyroid hormone in a highly tissue-specific manner","volume":"231","author":"Izumo","year":"1986","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib225","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1172\/JCI112908","article-title":"Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals","volume":"79","author":"Izumo","year":"1987","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib226","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1073\/pnas.85.2.339","article-title":"Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload","volume":"85","author":"Izumo","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib227","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/jb\/mvj032","article-title":"Attenuation of cardiac hypertrophy in carnitine-deficient juvenile visceral steatosis (JVS) mice achieved by lowering dietary lipid","volume":"139","author":"Jalil","year":"2006","journal-title":"J Biochem"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib228","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1677\/joe.1.05702","article-title":"Pregnancy alters nitric oxide synthase and natriuretic peptide systems in the rat left ventricle","volume":"184","author":"Jankowski","year":"2005","journal-title":"J Endocrinol"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib229","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1440-1681.1995.tb01982.x","article-title":"Mechanisms for reduction of cardiovascular risk by regular exercise","volume":"22","author":"Jennings","year":"1995","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib230","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1161\/01.CIR.73.1.30","article-title":"The effects of changes in physical activity on major cardiovascular risk factors, hemodynamics, sympathetic function, and glucose utilization in man: a controlled study of four levels of activity","volume":"73","author":"Jennings","year":"1986","journal-title":"Circulation"},{"issue":"48","key":"10.1016\/j.pharmthera.2010.04.005_bib231","doi-asserted-by":"crossref","first-page":"30122","DOI":"10.1074\/jbc.272.48.30122","article-title":"Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta","volume":"272","author":"Jiang","year":"1997","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib232","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.pharmthera.2008.08.009","article-title":"AT2 receptors: functional relevance in cardiovascular disease","volume":"120","author":"Jones","year":"2008","journal-title":"Pharmacol Ther"},{"issue":"5740","key":"10.1016\/j.pharmthera.2010.04.005_bib233","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1126\/science.1113329","article-title":"Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA","volume":"309","author":"Jopling","year":"2005","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.pharmthera.2010.04.005_bib234","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1161\/01.CIR.0000027563.44593.CC","article-title":"Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease: a population-based case\u2013control study","volume":"106","author":"Juul","year":"2002","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib235","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1172\/JCI9307","article-title":"Sex-related survival differences in murine cardiomyopathy are associated with differences in TNF-receptor expression","volume":"106","author":"Kadokami","year":"2000","journal-title":"J Clin Invest"},{"issue":"8","key":"10.1016\/j.pharmthera.2010.04.005_bib236","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1161\/01.CIR.0000030181.63741.56","article-title":"Angiotensin II-induced cardiac hypertrophy and hypertension are attenuated by epidermal growth factor receptor antisense","volume":"106","author":"Kagiyama","year":"2002","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib237","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.2337\/diabetes.50.6.1414","article-title":"IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress","volume":"50","author":"Kajstura","year":"2001","journal-title":"Diabetes"},{"issue":"2\u20133","key":"10.1016\/j.pharmthera.2010.04.005_bib238","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0167-5273(02)00182-1","article-title":"Do results of the ENABLE (Endothelin Antagonist Bosentan for Lowering Cardiac Events in Heart Failure) study spell the end for non-selective endothelin antagonism in heart failure?","volume":"85","author":"Kalra","year":"2002","journal-title":"Int J Cardiol"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib239","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1159\/000107791","article-title":"Clinical and hemodynamic effects of bosentan dose optimization in symptomatic heart failure patients with severe systolic dysfunction, associated with secondary pulmonary hypertension\u2014a multi-center randomized study","volume":"109","author":"Kaluski","year":"2008","journal-title":"Cardiology"},{"issue":"21","key":"10.1016\/j.pharmthera.2010.04.005_bib240","doi-asserted-by":"crossref","first-page":"12378","DOI":"10.1073\/pnas.2135217100","article-title":"PPARgamma coactivator 1beta\/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity","volume":"100","author":"Kamei","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"10.1016\/j.pharmthera.2010.04.005_bib241","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1161\/01.RES.86.11.1107","article-title":"Apoptosis and heart failure: a critical review of the literature","volume":"86","author":"Kang","year":"2000","journal-title":"Circ Res"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib242","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1253\/circj.66.1","article-title":"New insights into the role of apoptosis in cardiovascular disease","volume":"66","author":"Kang","year":"2002","journal-title":"Circ J"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib243","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00556.2003","article-title":"Alterations in apoptosis regulatory factors during hypertrophy and heart failure","author":"Kang","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"11","key":"10.1016\/j.pharmthera.2010.04.005_bib244","doi-asserted-by":"crossref","first-page":"4689","DOI":"10.1210\/jc.2006-0584","article-title":"Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to left ventricular function and serum free fatty acid levels","volume":"91","author":"Kankaanpaa","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib245","first-page":"27","article-title":"The Framingham Study: historical insight on the impact of cardiovascular risk factors in men versus women","volume":"5","author":"Kannel","year":"2002","journal-title":"J Gend Specif Med"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib246","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0022-2828(03)00002-6","article-title":"Nkx2.5 homeoprotein regulates expression of gap junction protein connexin 43 and sarcomere organization in postnatal cardiomyocytes","volume":"35","author":"Kasahara","year":"2003","journal-title":"J Mol Cell Cardiol"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib247","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.2215\/CJN.00520109","article-title":"MicroRNAs and their role in progressive kidney diseases","volume":"4","author":"Kato","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib248","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.pharmthera.2008.03.009","article-title":"The low-affinity site of the beta1-adrenoceptor and its relevance to cardiovascular pharmacology","volume":"118","author":"Kaumann","year":"2008","journal-title":"Pharmacol Ther"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib249","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1161\/01.CIR.99.1.65","article-title":"Activation of beta2-adrenergic receptors hastens relaxation and mediates phosphorylation of phospholamban, troponin I, and C-protein in ventricular myocardium from patients with terminal heart failure","volume":"99","author":"Kaumann","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib250","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1146\/annurev.pharmtox.41.1.851","article-title":"Endothelin system: the double-edged sword in health and disease","volume":"41","author":"Kedzierski","year":"2001","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"22","key":"10.1016\/j.pharmthera.2010.04.005_bib251","doi-asserted-by":"crossref","first-page":"8226","DOI":"10.1128\/MCB.23.22.8226-8232.2003","article-title":"Cardiomyocyte-specific endothelin A receptor knockout mice have normal cardiac function and an unaltered hypertrophic response to angiotensin II and isoproterenol","volume":"23","author":"Kedzierski","year":"2003","journal-title":"Mol Cell Biol"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib252","first-page":"696","article-title":"Clinical trials of endothelin antagonists in heart failure: a question of dose?","volume":"231","author":"Kelland","year":"2006","journal-title":"Exp Biol Med (Maywood)"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib253","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1210\/me.9.7.794","article-title":"Signaling cross-talk between peroxisome proliferator-activated receptor\/retinoid X receptor and estrogen receptor through estrogen response elements","volume":"9","author":"Keller","year":"1995","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib254","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M512671200","article-title":"Thyroid hormone stimulates protein synthesis in the cardiomyocyte by activating the Akt-mTOR and p70S6K pathways","author":"Kenessey","year":"2006","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib255","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1161\/CIRCRESAHA.107.156422","article-title":"PI3Kgamma is required for PDE4, not PDE3, activity in subcellular microdomains containing the sarcoplasmic reticular calcium ATPase in cardiomyocytes","volume":"101","author":"Kerfant","year":"2007","journal-title":"Circ Res"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib256","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1365-2567.2006.02336.x","article-title":"Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia","volume":"118","author":"Khan","year":"2006","journal-title":"Immunology"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib257","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1172\/JCI33255","article-title":"The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice","volume":"118","author":"Kim","year":"2008","journal-title":"J Clin Invest"},{"issue":"11","key":"10.1016\/j.pharmthera.2010.04.005_bib258","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1210\/me.2008-0265","article-title":"Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy","volume":"22","author":"Kim","year":"2008","journal-title":"Mol Endocrinol"},{"issue":"HEART IN STRESS","key":"10.1016\/j.pharmthera.2010.04.005_bib259","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1749-6632.1999.tb09227.x","article-title":"Cardiac adaptation to ischemia\u2013reperfusion injury","volume":"874","author":"Kingma","year":"1999","journal-title":"Ann NY Acad Sci"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib260","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0008-6363(98)00296-X","article-title":"Activity of cAMP-dependent protein kinase and Ca2+\/calmodulin-dependent protein kinase in failing and nonfailing human hearts","volume":"42","author":"Kirchhefer","year":"1999","journal-title":"Cardiovasc Res"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib261","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/sj.bjp.0707622","article-title":"Knockout of beta(1)- and beta(2)-adrenoceptors attenuates pressure overload-induced cardiac hypertrophy and fibrosis","volume":"153","author":"Kiriazis","year":"2008","journal-title":"Br J Pharmacol"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib262","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/sj.bjp.0707516","article-title":"The endothelin system as a therapeutic target in cardiovascular disease: great expectations or bleak house?","volume":"153","author":"Kirkby","year":"2008","journal-title":"Br J Pharmacol"},{"issue":"22","key":"10.1016\/j.pharmthera.2010.04.005_bib263","doi-asserted-by":"crossref","first-page":"13367","DOI":"10.1074\/jbc.273.22.13367","article-title":"Regulation of the calmodulin-stimulated protein phosphatase, calcineurin","volume":"273","author":"Klee","year":"1998","journal-title":"J Biol Chem"},{"issue":"12","key":"10.1016\/j.pharmthera.2010.04.005_bib264","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1007\/s00109-003-0488-x","article-title":"Cardiac mechanotransduction and implications for heart disease","volume":"81","author":"Knoll","year":"2003","journal-title":"J Mol Med"},{"issue":"5215","key":"10.1016\/j.pharmthera.2010.04.005_bib265","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1126\/science.7761854","article-title":"Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor","volume":"268","author":"Koch","year":"1995","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.pharmthera.2010.04.005_bib266","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1161\/01.RES.81.5.656","article-title":"Leukemia inhibitory factor, a potent cardiac hypertrophic cytokine, activates the JAK\/STAT pathway in rat cardiomyocytes","volume":"81","author":"Kodama","year":"1997","journal-title":"Circ Res"},{"issue":"12","key":"10.1016\/j.pharmthera.2010.04.005_bib267","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1093\/hmg\/8.12.2247","article-title":"Genetic epidemiology of the carnitine transporter OCTN2 gene in a Japanese population and phenotypic characterization in Japanese pedigrees with primary systemic carnitine deficiency","volume":"8","author":"Koizumi","year":"1999","journal-title":"Hum Mol Genet"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib268","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.tibs.2009.01.003","article-title":"Regulation of phosphoinositide 3-kinase expression in health and disease","volume":"34","author":"Kok","year":"2009","journal-title":"Trends Biochem Sci"},{"issue":"5","key":"10.1016\/j.pharmthera.2010.04.005_bib269","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1096\/fasebj.10.5.8621062","article-title":"Mechanical stretch activates the stress-activated protein kinases in cardiac myocytes","volume":"10","author":"Komuro","year":"1996","journal-title":"FASEB J"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib270","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1152\/physiolgenomics.00226.2004","article-title":"Genetic expression profiles during physiological and pathological cardiac hypertrophy and heart failure in rats","volume":"21","author":"Kong","year":"2005","journal-title":"Physiol Genomics"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib271","doi-asserted-by":"crossref","first-page":"H2768","DOI":"10.1152\/ajpheart.00292.2004","article-title":"Sex modifies exercise and cardiac adaptation in mice","volume":"287","author":"Konhilas","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib272","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1161\/01.RES.0000205766.97556.00","article-title":"Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy","volume":"98","author":"Konhilas","year":"2006","journal-title":"Circ Res"},{"issue":"19","key":"10.1016\/j.pharmthera.2010.04.005_bib273","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1161\/CIRCULATIONAHA.107.712901","article-title":"CD36 expression contributes to age-induced cardiomyopathy in mice","volume":"116","author":"Koonen","year":"2007","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.pharmthera.2010.04.005_bib274","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1091\/mbc.12.8.2290","article-title":"Focal adhesion kinase and p130Cas mediate both sarcomeric organization and activation of genes associated with cardiac myocyte hypertrophy","volume":"12","author":"Kovacic-Milivojevic","year":"2001","journal-title":"Mol Biol Cell"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib275","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1152\/jappl.1999.86.4.1436","article-title":"Serum levels of total and free IGF-I and IGFBP-3 are increased and maintained in long-term training","volume":"86","author":"Koziris","year":"1999","journal-title":"J Appl Physiol"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib276","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.cmet.2009.05.005","article-title":"Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy","volume":"9","author":"Krishnan","year":"2009","journal-title":"Cell Metab"},{"issue":"9667","key":"10.1016\/j.pharmthera.2010.04.005_bib277","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S0140-6736(09)60236-1","article-title":"Heart failure","volume":"373","author":"Krum","year":"2009","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib278","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/0002-9149(93)90678-6","article-title":"Sex differences in cardiac adaptation to isolated systolic hypertension","volume":"72","author":"Krumholz","year":"1993","journal-title":"Am J Cardiol"},{"issue":"7068","key":"10.1016\/j.pharmthera.2010.04.005_bib279","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nature04303","article-title":"Silencing of microRNAs in vivo with \u2018antagomirs\u2019","volume":"438","author":"Krutzfeldt","year":"2005","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib280","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1073\/pnas.97.1.315","article-title":"Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy","volume":"97","author":"Kunisada","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib281","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1006\/jmcc.1998.0641","article-title":"Characteristics of cardiac hypertrophy in the juvenile visceral steatosis mouse with systemic carnitine deficiency","volume":"30","author":"Kuwajima","year":"1998","journal-title":"J Mol Cell Cardiol"},{"issue":"12","key":"10.1016\/j.pharmthera.2010.04.005_bib282","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/ncpcardio0371","article-title":"Chronic heart failure: an overview of conventional treatment versus novel approaches","volume":"2","author":"Landmesser","year":"2005","journal-title":"Nat Clin Pract Cardiovasc Med"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib283","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1006\/dbio.2001.0248","article-title":"Lineage analysis in the chicken inner ear shows differences in clonal dispersion for epithelial, neuronal, and mesenchymal cells","volume":"234","author":"Lang","year":"2001","journal-title":"Dev Biol"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib284","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.cardiores.2006.07.006","article-title":"Antioxidant actions contribute to the antihypertrophic effects of atrial natriuretic peptide in neonatal rat cardiomyocytes","volume":"72","author":"Laskowski","year":"2006","journal-title":"Cardiovasc Res"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib285","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1152\/physiolgenomics.90254.2008","article-title":"MicroRNA and cardiac pathologies","volume":"34","author":"Latronico","year":"2008","journal-title":"Physiol Genomics"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib286","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1161\/01.HYP.13.2.151","article-title":"Prevalence of cardiac structural and functional abnormalities in untreated primary hypertension","volume":"13","author":"Laufer","year":"1989","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib287","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1210\/jc.2003-030967","article-title":"The prospective association of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: the Rancho Bernardo Study","volume":"89","author":"Laughlin","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib288","first-page":"184","article-title":"Thyroid hormone receptors: multiple forms, multiple possibilities","volume":"14","author":"Lazar","year":"1993","journal-title":"Endocr Rev"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib289","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1172\/JCI114906","article-title":"Nuclear thyroid hormone receptors","volume":"86","author":"Lazar","year":"1990","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib290","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1161\/HYPERTENSIONAHA.107.092403","article-title":"Effects of fenofibrate on cardiac remodeling in aldosterone-induced hypertension","volume":"50","author":"Lebrasseur","year":"2007","journal-title":"Hypertension"},{"issue":"5721","key":"10.1016\/j.pharmthera.2010.04.005_bib291","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1126\/science.1108784","article-title":"A cellular microRNA mediates antiviral defense in human cells","volume":"308","author":"Lecellier","year":"2005","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.pharmthera.2010.04.005_bib292","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14","volume":"75","author":"Lee","year":"1993","journal-title":"Cell"},{"issue":"23","key":"10.1016\/j.pharmthera.2010.04.005_bib293","doi-asserted-by":"crossref","first-page":"6584","DOI":"10.1002\/j.1460-2075.1996.tb01049.x","article-title":"The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth","volume":"15","author":"Leevers","year":"1996","journal-title":"EMBO J"},{"issue":"14","key":"10.1016\/j.pharmthera.2010.04.005_bib294","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1161\/01.CIR.101.14.1634","article-title":"Catecholamines, cardiac beta-adrenergic receptors, and heart failure","volume":"101","author":"Lefkowitz","year":"2000","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib295","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1023\/A:1015332726303","article-title":"Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth","volume":"7","author":"Lehman","year":"2002","journal-title":"Heart Fail Rev"},{"issue":"8","key":"10.1016\/j.pharmthera.2010.04.005_bib296","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1006\/jmcc.2001.1415","article-title":"Decreased p38 MAPK activity in end-stage failing human myocardium: p38 MAPK alpha is the predominant isoform expressed in human heart","volume":"33","author":"Lemke","year":"2001","journal-title":"J Mol Cell Cardiol"},{"issue":"9","key":"10.1016\/j.pharmthera.2010.04.005_bib297","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/0002-9149(87)91133-7","article-title":"Echocardiographic criteria for left ventricular hypertrophy: the Framingham Heart Study","volume":"59","author":"Levy","year":"1987","journal-title":"Am J Cardiol"},{"issue":"22","key":"10.1016\/j.pharmthera.2010.04.005_bib298","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1056\/NEJM199005313222203","article-title":"Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study","volume":"322","author":"Levy","year":"1990","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib299","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets","volume":"120","author":"Lewis","year":"2005","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.pharmthera.2010.04.005_bib300","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1172\/JCI119730","article-title":"Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy","volume":"100","author":"Li","year":"1997","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib301","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1006\/bbrc.1998.8662","article-title":"Activation of JNK in the remote myocardium after large myocardial infarction in rats","volume":"246","author":"Li","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"issue":"9","key":"10.1016\/j.pharmthera.2010.04.005_bib302","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1161\/01.RES.84.9.1007","article-title":"Insulin-like growth factor-1 attenuates the detrimental impact of nonocclusive coronary artery constriction on the heart","volume":"84","author":"Li","year":"1999","journal-title":"Circ Res"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib303","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/sj.bjp.0706217","article-title":"Activation of calcineurin in human failing heart ventricle by endothelin-1, angiotensin II and urotensin II","volume":"145","author":"Li","year":"2005","journal-title":"Br J Pharmacol"},{"issue":"19","key":"10.1016\/j.pharmthera.2010.04.005_bib304","doi-asserted-by":"crossref","first-page":"5079","DOI":"10.1093\/emboj\/cdg474","article-title":"c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling","volume":"22","author":"Liang","year":"2003","journal-title":"EMBO J"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib305","doi-asserted-by":"crossref","first-page":"F553","DOI":"10.1152\/ajprenal.00045.2009","article-title":"MicroRNA: a new frontier in kidney and blood pressure research","volume":"297","author":"Liang","year":"2009","journal-title":"Am J Physiol Ren Physiol"},{"issue":"21","key":"10.1016\/j.pharmthera.2010.04.005_bib306","doi-asserted-by":"crossref","first-page":"12283","DOI":"10.1073\/pnas.211086598","article-title":"The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy","volume":"98","author":"Liao","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1016\/j.pharmthera.2010.04.005_bib307","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1006\/jmcc.1999.0934","article-title":"Renin\u2013angiotensin system, hypertrophy and gene expression in cardiac myocytes","volume":"31","author":"Lijnen","year":"1999","journal-title":"J Mol Cell Cardiol"},{"issue":"20","key":"10.1016\/j.pharmthera.2010.04.005_bib308","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1161\/01.CIR.101.20.2431","article-title":"Calcineurin expression, activation, and function in cardiac pressure-overload hypertrophy","volume":"101","author":"Lim","year":"2000","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib309","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1161\/ATVBAHA.109.201988","article-title":"PI3K(p110alpha) protects against myocardial infarction-induced heart failure: identification of PI3K-regulated miRNAs and mRNAs","volume":"30","author":"Lin","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib310","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1586\/14779072.4.6.927","article-title":"Genetic basis of hypertrophic cardiomyopathy","volume":"4","author":"Lind","year":"2006","journal-title":"Expert Rev Cardiovasc Ther"},{"issue":"5","key":"10.1016\/j.pharmthera.2010.04.005_bib311","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1172\/JCI38022","article-title":"Requirement for Ca2+\/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice","volume":"119","author":"Ling","year":"2009","journal-title":"J Clin Invest"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib312","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/aps.2009.58","article-title":"The peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonist, AVE8134, attenuates the progression of heart failure and increases survival in rats","volume":"30","author":"Linz","year":"2009","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib313","first-page":"11","article-title":"The inhibitory effect of trilinolein on norepinephrine-induced beta-myosin heavy chain promoter activity, reactive oxygen species generation, and extracellular signal-regulated kinase phosphorylation in neonatal rat cardiomyocytes","volume":"11","author":"Liu","year":"2004","journal-title":"J Biomed Sci"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib314","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.yjmcc.2006.07.007","article-title":"Pressure overload induces greater hypertrophy and mortality in female mice with p38alpha MAPK inhibition","volume":"41","author":"Liu","year":"2006","journal-title":"J Mol Cell Cardiol"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib315","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1161\/CIRCRESAHA.108.188292","article-title":"Cardiac-specific deletion of mkk4 reveals its role in pathological hypertrophic remodeling but not in physiological cardiac growth","volume":"104","author":"Liu","year":"2009","journal-title":"Circ Res"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib316","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1161\/CIRCULATIONAHA.108.191259","article-title":"Heart Disease and Stroke Statistics\u20142009 Update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee","volume":"119","author":"Lloyd-Jones","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib317","doi-asserted-by":"crossref","DOI":"10.1016\/B978-012656975-9\/50036-5","article-title":"Adrenergic receptors in the cardiovascular system","author":"Lomasney","year":"2001"},{"issue":"12A","key":"10.1016\/j.pharmthera.2010.04.005_bib318","doi-asserted-by":"crossref","first-page":"48H","DOI":"10.1016\/S0002-9149(99)00258-1","article-title":"Role of angiotensin AT1, and AT2 receptors in cardiac hypertrophy and disease","volume":"83","author":"Lorell","year":"1999","journal-title":"Am J Cardiol"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib319","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nm.1893","article-title":"A new type of ERK1\/2 autophosphorylation causes cardiac hypertrophy","volume":"15","author":"Lorenz","year":"2009","journal-title":"Nat Med"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib320","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S1388-9842(01)00149-0","article-title":"Clinical Trials Update: CAPRICORN, COPERNICUS, MIRACLE, STAF, RITZ-2, RECOVER and RENAISSANCE and cachexia and cholesterol in heart failure. Highlights of the Scientific Sessions of the American College of Cardiology, 2001","volume":"3","author":"Louis","year":"2001","journal-title":"Eur J Heart Fail"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib321","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1161\/CIRCULATIONAHA.109.873380","article-title":"Loss of cardiac phosphoinositide 3-kinase p110{alpha} results in contractile dysfunction","volume":"120","author":"Lu","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib322","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.physiol.010908.163156","article-title":"Sex-based cardiac physiology","volume":"71","author":"Luczak","year":"2009","journal-title":"Ann Rev Physiol"},{"issue":"21","key":"10.1016\/j.pharmthera.2010.04.005_bib323","doi-asserted-by":"crossref","first-page":"9491","DOI":"10.1128\/MCB.25.21.9491-9502.2005","article-title":"Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy","volume":"25","author":"Luo","year":"2005","journal-title":"Mol Cell Biol"},{"issue":"21","key":"10.1016\/j.pharmthera.2010.04.005_bib324","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1161\/01.CIR.0000038497.80095.E1","article-title":"Hemodynamic and neurohumoral effects of selective endothelin A (ET(A)) receptor blockade in chronic heart failure: the Heart Failure ET(A) Receptor Blockade Trial (HEAT)","volume":"106","author":"Luscher","year":"2002","journal-title":"Circulation"},{"issue":"46","key":"10.1016\/j.pharmthera.2010.04.005_bib325","doi-asserted-by":"crossref","first-page":"30131","DOI":"10.1074\/jbc.273.46.30131","article-title":"Estrogen-induced production of a peroxisome proliferator-activated receptor (PPAR) ligand in a PPARgamma-expressing tissue","volume":"273","author":"Ma","year":"1998","journal-title":"J Biol Chem"},{"issue":"15","key":"10.1016\/j.pharmthera.2010.04.005_bib326","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1161\/01.CIR.0000144460.84795.E3","article-title":"Hypertrophy, fibrosis, and sudden cardiac death in response to pathological stimuli in mice with mutations in cardiac troponin T","volume":"110","author":"Maass","year":"2004","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib327","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1006\/jmcc.2001.1400","article-title":"Localization, anchoring, and functions of protein kinase C isozymes in the heart","volume":"33","author":"Mackay","year":"2001","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib328","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.physiol.62.1.289","article-title":"Genetic dissection of cardiac growth control pathways","volume":"62","author":"MacLellan","year":"2000","journal-title":"Annu Rev Physiol"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib329","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1096\/fj.05-5148com","article-title":"Estrogen receptor alpha up-regulation and redistribution in human heart failure","volume":"20","author":"Mahmoodzadeh","year":"2006","journal-title":"FASEB J"},{"issue":"12","key":"10.1016\/j.pharmthera.2010.04.005_bib330","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1161\/01.RES.0000046452.67724.B8","article-title":"Gene expression in fibroblasts and fibrosis: involvement in cardiac hypertrophy","volume":"91","author":"Manabe","year":"2002","journal-title":"Circ Res"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib331","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/0092-8674(95)90199-X","article-title":"The nuclear receptor superfamily: the second decade","volume":"83","author":"Mangelsdorf","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib332","series-title":"Myocyte Abnormalities in Human Heart Failure","first-page":"41","author":"Margulies","year":"2004"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib333","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s004290050070","article-title":"Embryonic and postnatal development of the rat renal interstitium","volume":"195","author":"Maric","year":"1997","journal-title":"Anat Embryol (Berl)"},{"issue":"11","key":"10.1016\/j.pharmthera.2010.04.005_bib334","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1056\/NEJMra022783","article-title":"Sudden death in young athletes","volume":"349","author":"Maron","year":"2003","journal-title":"N Engl J Med"},{"issue":"15","key":"10.1016\/j.pharmthera.2010.04.005_bib335","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1161\/CIRCULATIONAHA.106.613562","article-title":"The heart of trained athletes: cardiac remodeling and the risks of sports, including sudden death","volume":"114","author":"Maron","year":"2006","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib336","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/S0735-1097(98)00491-4","article-title":"Prevalence of sudden cardiac death during competitive sports activities in Minnesota high school athletes","volume":"32","author":"Maron","year":"1998","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib337","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1172\/JCI1885","article-title":"Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects","volume":"101","author":"Masaki","year":"1998","journal-title":"J Clin Invest"},{"issue":"52","key":"10.1016\/j.pharmthera.2010.04.005_bib338","doi-asserted-by":"crossref","first-page":"20900","DOI":"10.1073\/pnas.0808315106","article-title":"Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload","volume":"105","author":"Matsuda","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib339","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.yjmcc.2004.11.005","article-title":"Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt","volume":"38","author":"Matsui","year":"2005","journal-title":"J Mol Cell Cardiol"},{"issue":"25","key":"10.1016\/j.pharmthera.2010.04.005_bib340","doi-asserted-by":"crossref","first-page":"22896","DOI":"10.1074\/jbc.M200347200","article-title":"Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart","volume":"277","author":"Matsui","year":"2002","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.pharmthera.2010.04.005_bib341","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/BF00788498","article-title":"Novel and uncommon isoforms of the calcium sensing enzyme calcium\/calmodulin dependent protein kinase II in heart tissue","volume":"90","author":"Mayer","year":"1995","journal-title":"Basic Res Cardiol"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib342","doi-asserted-by":"crossref","first-page":"517","DOI":"10.7326\/0003-4819-144-7-200604040-00011","article-title":"Adiposity of the heart, revisited","volume":"144","author":"McGavock","year":"2006","journal-title":"Ann Intern Med"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib343","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0955-0674(02)00389-7","article-title":"Signaling chromatin to make muscle","volume":"14","author":"McKinsey","year":"2002","journal-title":"Curr Opin Cell Biol"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib344","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1440-1681.2007.04873.x","article-title":"Role of insulin-like growth factor 1 and phosphoinositide 3-kinase in a setting of heart disease","volume":"35","author":"McMullen","year":"2008","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib345","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1161\/HYPERTENSIONAHA.109.137976","article-title":"Nectin-2: an intercalated disc protein that maintains cardiac function in a setting of pressure overload","volume":"54","author":"McMullen","year":"2009","journal-title":"Hypertension"},{"issue":"8","key":"10.1016\/j.pharmthera.2010.04.005_bib346","doi-asserted-by":"crossref","DOI":"10.4161\/cc.6.8.4124","article-title":"PI3K(p110alpha) inhibitors as anti-cancer agents: minding the heart","volume":"6","author":"McMullen","year":"2007","journal-title":"Cell Cycle"},{"issue":"21","key":"10.1016\/j.pharmthera.2010.04.005_bib347","doi-asserted-by":"crossref","first-page":"12355","DOI":"10.1073\/pnas.1934654100","article-title":"Phosphoinositide 3-kinase(p110alpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy","volume":"100","author":"McMullen","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"24","key":"10.1016\/j.pharmthera.2010.04.005_bib348","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1161\/01.CIR.0000130641.08705.45","article-title":"Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload","volume":"109","author":"McMullen","year":"2004","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib349","doi-asserted-by":"crossref","first-page":"4782","DOI":"10.1074\/jbc.M310405200","article-title":"The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway","volume":"279","author":"McMullen","year":"2004","journal-title":"J Biol Chem"},{"issue":"14","key":"10.1016\/j.pharmthera.2010.04.005_bib350","doi-asserted-by":"crossref","first-page":"6231","DOI":"10.1128\/MCB.24.14.6231-6240.2004","article-title":"Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy","volume":"24","author":"McMullen","year":"2004","journal-title":"Mol Cell Biol"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib351","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1073\/pnas.0606663104","article-title":"Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy","volume":"104","author":"McMullen","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9474","key":"10.1016\/j.pharmthera.2010.04.005_bib352","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1016\/S0140-6736(05)66621-4","article-title":"Heart failure","volume":"365","author":"McMurray","year":"2005","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.pharmthera.2010.04.005_bib354","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1093\/eurheartj\/14.11.1493","article-title":"Evidence of oxidative stress in chronic heart failure in humans","volume":"14","author":"McMurray","year":"1993","journal-title":"Eur Heart J"},{"issue":"23","key":"10.1016\/j.pharmthera.2010.04.005_bib355","doi-asserted-by":"crossref","first-page":"13893","DOI":"10.1073\/pnas.95.23.13893","article-title":"Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways","volume":"95","author":"Mende","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5728","key":"10.1016\/j.pharmthera.2010.04.005_bib356","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1126\/science.1112062","article-title":"Molecular and cellular basis of cardiovascular gender differences","volume":"308","author":"Mendelsohn","year":"2005","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib357","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0008-6363(01)00466-7","article-title":"Estrogen replacement therapy, atherosclerosis, and vascular function","volume":"53","author":"Mikkola","year":"2002","journal-title":"Cardiovasc Res"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib358","doi-asserted-by":"crossref","first-page":"3866","DOI":"10.1073\/pnas.062453699","article-title":"MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq","volume":"99","author":"Minamino","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib359","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1152\/physiolgenomics.00028.2006","article-title":"Physiological genomics of cardiac disease: quantitative relationships between gene expression and left ventricular hypertrophy","volume":"27","author":"Mirotsou","year":"2006","journal-title":"Physiol Genomics"},{"issue":"6 Pt 2","key":"10.1016\/j.pharmthera.2010.04.005_bib360","first-page":"H2443","article-title":"Hypertrophic growth of cultured neonatal rat heart cells mediated by type 1 angiotensin II receptor","volume":"266","author":"Miyata","year":"1994","journal-title":"Am J Physiol"},{"issue":"12","key":"10.1016\/j.pharmthera.2010.04.005_bib361","doi-asserted-by":"crossref","DOI":"10.1291\/hypres.29.1029","article-title":"Comparison of gene expression profiling in pressure and volume overload-induced myocardial hypertrophies in rats","volume":"29","author":"Miyazaki","year":"2006","journal-title":"Hypertens Res"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib362","doi-asserted-by":"crossref","first-page":"H976","DOI":"10.1152\/ajpheart.2000.279.3.H976","article-title":"Early sequence of cardiac adaptations and growth factor formation in pressure- and volume-overload hypertrophy","volume":"279","author":"Modesti","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib363","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/MNH.0b013e328324f5fa","article-title":"New insights into the regulation of angiotensin receptors","volume":"18","author":"Mogi","year":"2009","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib364","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.tips.2005.05.005","article-title":"Fundamental considerations of beta-adrenoceptor subtypes in human heart failure","volume":"26","author":"Molenaar","year":"2005","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib365","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1146\/annurev.physiol.63.1.391","article-title":"Cytoplasmic signaling pathways that regulate cardiac hypertrophy","volume":"63","author":"Molkentin","year":"2001","journal-title":"Annu Rev Physiol"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib366","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0092-8674(00)81573-1","article-title":"A calcineurin-dependent transcriptional pathway for cardiac hypertrophy","volume":"93","author":"Molkentin","year":"1998","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.pharmthera.2010.04.005_bib367","doi-asserted-by":"crossref","first-page":"5557","DOI":"10.1210\/en.2006-0729","article-title":"Minireview: estrogen receptor-mediated rapid signaling","volume":"147","author":"Moriarty","year":"2006","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib368","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1093\/cvr\/cvm084","article-title":"Sarcomeric proteins and inherited cardiomyopathies","volume":"77","author":"Morimoto","year":"2008","journal-title":"Cardiovasc Res"},{"issue":"19","key":"10.1016\/j.pharmthera.2010.04.005_bib369","doi-asserted-by":"crossref","first-page":"14466","DOI":"10.1074\/jbc.275.19.14466","article-title":"The Akt-glycogen synthase kinase 3beta pathway regulates transcription of atrial natriuretic factor induced by beta-adrenergic receptor stimulation in cardiac myocytes","volume":"275","author":"Morisco","year":"2000","journal-title":"J Biol Chem"},{"issue":"30","key":"10.1016\/j.pharmthera.2010.04.005_bib370","doi-asserted-by":"crossref","first-page":"28586","DOI":"10.1074\/jbc.M103166200","article-title":"Glycogen synthase kinase 3beta regulates GATA4 in cardiac myocytes","volume":"276","author":"Morisco","year":"2001","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib371","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/01.RES.0000231290.45676.d4","article-title":"Myostatin regulates cardiomyocyte growth through modulation of Akt signaling","volume":"99","author":"Morissette","year":"2006","journal-title":"Circ Res"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib372","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/1097-0029(20000915)50:6<522::AID-JEMT9>3.0.CO;2-U","article-title":"Control of cardiac myosin heavy chain gene expression","volume":"50","author":"Morkin","year":"2000","journal-title":"Microsc Res Tech"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib373","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.cardiores.2006.03.016","article-title":"NADPH oxidase-dependent redox signalling in cardiac hypertrophy, remodelling and failure","volume":"71","author":"Murdoch","year":"2006","journal-title":"Cardiovasc Res"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib374","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1042\/CS20070430","article-title":"MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets","volume":"115","author":"Muslin","year":"2008","journal-title":"Clin Sci (Lond)"},{"issue":"109","key":"10.1016\/j.pharmthera.2010.04.005_bib375","first-page":"41","article-title":"Study of non-muscle cells of the adult mammalian heart: a fine structural analysis and distribution","volume":"28","author":"Nag","year":"1980","journal-title":"Cytobios"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib376","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1074\/jbc.275.7.4693","article-title":"Gbetagamma-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy","volume":"275","author":"Naga Prasad","year":"2000","journal-title":"J Biol Chem"},{"issue":"22","key":"10.1016\/j.pharmthera.2010.04.005_bib377","doi-asserted-by":"crossref","first-page":"18953","DOI":"10.1074\/jbc.M102376200","article-title":"Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration","volume":"276","author":"Naga Prasad","year":"2001","journal-title":"J Biol Chem"},{"issue":"8","key":"10.1016\/j.pharmthera.2010.04.005_bib378","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/cvr\/22.8.575","article-title":"Postnatal DNA synthesis in hearts of mice: autoradiographic and cytofluorometric investigations","volume":"22","author":"Nakagawa","year":"1988","journal-title":"Cardiovasc Res"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib379","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0092-8674(95)90407-7","article-title":"Heterotrimeric G proteins: organizers of transmembrane signals","volume":"80","author":"Neer","year":"1995","journal-title":"Cell"},{"issue":"8505","key":"10.1016\/j.pharmthera.2010.04.005_bib380","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0140-6736(86)90354-5","article-title":"Effect of changing levels of physical activity on blood-pressure and haemodynamics in essential hypertension","volume":"2","author":"Nelson","year":"1986","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.pharmthera.2010.04.005_bib381","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1161\/hh0901.089882","article-title":"Cardiac angiotensin II formation in the clinical course of heart failure and its relationship with left ventricular function","volume":"88","author":"Neri Serneri","year":"2001","journal-title":"Circ Res"},{"issue":"11","key":"10.1016\/j.pharmthera.2010.04.005_bib382","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1161\/hh2301.100982","article-title":"Increased cardiac sympathetic activity and insulin-like growth factor-I formation are associated with physiological hypertrophy in athletes","volume":"89","author":"Neri Serneri","year":"2001","journal-title":"Circ Res"},{"issue":"11","key":"10.1016\/j.pharmthera.2010.04.005_bib383","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1056\/NEJMra063052","article-title":"The failing heart\u2014an engine out of fuel","volume":"356","author":"Neubauer","year":"2007","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1016\/j.pharmthera.2010.04.005_bib384","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1093\/emboj\/20.11.2757","article-title":"Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy","volume":"20","author":"Nicol","year":"2001","journal-title":"EMBO J"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib385","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1172\/JCI18213","article-title":"Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure","volume":"112","author":"Nienaber","year":"2003","journal-title":"J Clin Invest"},{"issue":"24","key":"10.1016\/j.pharmthera.2010.04.005_bib386","doi-asserted-by":"crossref","first-page":"10611","DOI":"10.1128\/MCB.24.24.10611-10620.2004","article-title":"p38{alpha} mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload","volume":"24","author":"Nishida","year":"2004","journal-title":"Mol Cell Biol"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib387","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1161\/CIRCRESAHA.108.175448","article-title":"Crosstalk between autophagy and apoptosis in heart disease","volume":"103","author":"Nishida","year":"2008","journal-title":"Circ Res"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib388","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/cdd.2008.163","article-title":"The role of autophagy in the heart","volume":"16","author":"Nishida","year":"2009","journal-title":"Cell Death Differ"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib389","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0008-6363(98)00135-7","article-title":"Effects of thyroid status on expression of voltage-gated potassium channels in rat left ventricle","volume":"40","author":"Nishiyama","year":"1998","journal-title":"Cardiovasc Res"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib390","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0303-7207(96)03980-9","article-title":"Retinoid X receptor and peroxisome proliferator-activated receptor activate an estrogen responsive gene independent of the estrogen receptor","volume":"127","author":"Nunez","year":"1997","journal-title":"Mol Cell Endocrinol"},{"issue":"11","key":"10.1016\/j.pharmthera.2010.04.005_bib391","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1172\/JCI200316100","article-title":"The alpha(1A\/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse","volume":"111","author":"O'Connell","year":"2003","journal-title":"J Clin Investig"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib392","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1172\/JCI22811","article-title":"Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload","volume":"116","author":"O'Connell","year":"2006","journal-title":"J Clin Invest"},{"issue":"10","key":"10.1016\/j.pharmthera.2010.04.005_bib393","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1111\/j.1440-1681.2005.04272.x","article-title":"High-fat diet prevents cardiac hypertrophy and improves contractile function in the hypertensive dahl salt-sensitive rat","volume":"32","author":"Okere","year":"2005","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"26","key":"10.1016\/j.pharmthera.2010.04.005_bib394","doi-asserted-by":"crossref","first-page":"15496","DOI":"10.1073\/pnas.95.26.15496","article-title":"Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II","volume":"95","author":"Oliverio","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib395","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/0735-1097(95)00282-8","article-title":"Gender differences and aging: effects on the human heart","volume":"26","author":"Olivetti","year":"1995","journal-title":"J Am Coll Cardiol"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib396","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0092-8674(00)80880-6","article-title":"Calcineurin signaling and muscle remodeling","volume":"101","author":"Olson","year":"2000","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib397","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1172\/JCI118132","article-title":"Favorable left ventricular remodeling following large myocardial infarction by exercise training. Effect on ventricular morphology and gene expression","volume":"96","author":"Orenstein","year":"1995","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib398","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10557-007-6014-6","article-title":"Myocardial phosphodiesterases and regulation of cardiac contractility in health and cardiac disease","volume":"21","author":"Osadchii","year":"2007","journal-title":"Cardiovasc Drugs Ther"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib399","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1152\/physrev.1999.79.3.635","article-title":"Development of cardiac sensitivity to oxygen deficiency: comparative and ontogenetic aspects","volume":"79","author":"Ostadal","year":"1999","journal-title":"Physiol Rev"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib400","doi-asserted-by":"crossref","first-page":"295","DOI":"10.2174\/187152907782793545","article-title":"Role of PI3 kinase gamma in excitation\u2013contraction coupling and heart disease","volume":"7","author":"Oudit","year":"2007","journal-title":"Cardiovasc Hematol Disord Drug Targets"},{"issue":"17","key":"10.1016\/j.pharmthera.2010.04.005_bib401","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1161\/01.CIR.0000091403.62293.2B","article-title":"Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure","volume":"108","author":"Oudit","year":"2003","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib402","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.yjmcc.2004.05.015","article-title":"The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease","volume":"37","author":"Oudit","year":"2004","journal-title":"J Mol Cell Cardiol"},{"issue":"5","key":"10.1016\/j.pharmthera.2010.04.005_bib403","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1042\/CS20080183","article-title":"The protective effects of exercise and phosphoinositide 3-kinase (p110alpha) in the failing heart","volume":"116","author":"Owen","year":"2009","journal-title":"Clin Sci (Lond)"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib404","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cardfail.2004.05.006","article-title":"Clinical effects of endothelin receptor antagonism with bosentan in patients with severe chronic heart failure: results of a pilot study","volume":"11","author":"Packer","year":"2005","journal-title":"J Card Fail"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib405","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1073\/pnas.97.2.931","article-title":"Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling","volume":"97","author":"Paradis","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib406","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/MOL.0b013e32814a57db","article-title":"Lipids in the heart: a source of fuel and a source of toxins","volume":"18","author":"Park","year":"2007","journal-title":"Curr Opin Lipidol"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib407","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1074\/jbc.272.1.154","article-title":"Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3\u2032-kinase and mitogen-activated protein kinase pathways","volume":"272","author":"Parrizas","year":"1997","journal-title":"J Biol Chem"},{"issue":"10","key":"10.1016\/j.pharmthera.2010.04.005_bib408","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1161\/01.RES.0000020201.44772.67","article-title":"Cardiomyocyte cell cycle regulation","volume":"90","author":"Pasumarthi","year":"2002","journal-title":"Circ Res"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib409","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.cell.2004.07.017","article-title":"PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects","volume":"118","author":"Patrucco","year":"2004","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib410","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.tcm.2006.01.002","article-title":"Estrogen replacement and cardiomyocyte protection","volume":"16","author":"Patten","year":"2006","journal-title":"Trends Cardiovasc Med"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib411","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/j.1460-2075.1991.tb08021.x","article-title":"Identification of the regulatory phosphorylation sites in pp 42\/mitogen-activated protein kinase (MAP kinase)","volume":"10","author":"Payne","year":"1991","journal-title":"EMBO J"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib412","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1210\/er.22.2.153","article-title":"Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions","volume":"22","author":"Pearson","year":"2001","journal-title":"Endocr Rev"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib413","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1432-1033.1997.00615.x","article-title":"The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs)","volume":"248","author":"Pellegrini","year":"1997","journal-title":"Eur J Biochem"},{"issue":"12","key":"10.1016\/j.pharmthera.2010.04.005_bib414","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1161\/01.CIR.0000159262.18512.46","article-title":"Increased mortality and aggravation of heart failure in estrogen receptor-beta knockout mice after myocardial infarction","volume":"111","author":"Pelzer","year":"2005","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib415","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1172\/JCI24497","article-title":"Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice","volume":"116","author":"Peng","year":"2006","journal-title":"J Clin Invest"},{"issue":"20","key":"10.1016\/j.pharmthera.2010.04.005_bib416","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1161\/CIRCULATIONAHA.104.508796","article-title":"Restoration of beta-adrenergic receptor signaling and contractile function in heart failure by disruption of the betaARK1\/phosphoinositide 3-kinase complex","volume":"111","author":"Perrino","year":"2005","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib417","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1172\/JCI25397","article-title":"Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction","volume":"116","author":"Perrino","year":"2006","journal-title":"J Clin Invest"},{"issue":"22","key":"10.1016\/j.pharmthera.2010.04.005_bib418","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1161\/CIRCULATIONAHA.107.706515","article-title":"Dynamic regulation of phosphoinositide 3-kinase-gamma activity and beta-adrenergic receptor trafficking in end-stage human heart failure","volume":"116","author":"Perrino","year":"2007","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib419","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.tcm.2003.11.002","article-title":"Stress-activated MAP kinases in cardiac remodeling and heart failure; new insights from transgenic studies","volume":"14","author":"Petrich","year":"2004","journal-title":"Trends Cardiovasc Med"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib420","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1096\/fj.02-0438fje","article-title":"Temporal activation of c-Jun N-terminal kinase in adult transgenic heart via cre-loxP-mediated DNA recombination","volume":"17","author":"Petrich","year":"2003","journal-title":"FASEB J"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib603","doi-asserted-by":"crossref","unstructured":"Petrich, B.G., Eloff, B. C., Lerner, D. L., Kovacs, A., Saffitz, J. E., Rosenbaum, D. S., et al. (2004). Targeted activation of c-Jun N-terminal kinase in vivo induces restrictive cardiomyopathy and conduction defects. J Biol Chem 279(15), 15330\u201315338.","DOI":"10.1074\/jbc.M314142200"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib421","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1161\/01.CIR.101.3.336","article-title":"The athlete's heart. A meta-analysis of cardiac structure and function","volume":"101","author":"Pluim","year":"2000","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib422","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ejcts.2006.10.041","article-title":"Unveiling gender differences in demand ischemia: a study in a rat model of genetic hypertension","volume":"31","author":"Podesser","year":"2007","journal-title":"Eur J Cardio-Thor Surg"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib423","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1582-4934.2006.tb00410.x","article-title":"Insights into the interstitium of ventricular myocardium: interstitial Cajal-like cells (ICLC)","volume":"10","author":"Popescu","year":"2006","journal-title":"J Cell Mol Med"},{"issue":"5","key":"10.1016\/j.pharmthera.2010.04.005_bib424","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1172\/JCI2552","article-title":"A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy","volume":"102","author":"Pracyk","year":"1998","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib425","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1440-1681.2008.04893.x","article-title":"Promoting physiological hypertrophy in the failing heart","volume":"35","author":"Pretorius","year":"2008","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib426","doi-asserted-by":"crossref","first-page":"998","DOI":"10.2353\/ajpath.2009.090126","article-title":"Reduced phosphoinositide 3-kinase (p110alpha) activation increases the susceptibility to atrial fibrillation","volume":"175","author":"Pretorius","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib427","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.2741\/3374","article-title":"Role of phosphoinositide 3-kinases in regulating cardiac function","volume":"14","author":"Pretorius","year":"2009","journal-title":"Front Biosci"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib428","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1161\/01.RES.0000069211.82346.46","article-title":"NFAT transcription factors are critical survival factors that inhibit cardiomyocyte apoptosis during phenylephrine stimulation in vitro","volume":"92","author":"Pu","year":"2003","journal-title":"Circ Res"},{"issue":"35","key":"10.1016\/j.pharmthera.2010.04.005_bib429","doi-asserted-by":"crossref","first-page":"14074","DOI":"10.1073\/pnas.0610906104","article-title":"Genetic inhibition of cardiac ERK1\/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo","volume":"104","author":"Purcell","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib430","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1161\/CIRCRESAHA.107.168336","article-title":"G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure","volume":"103","author":"Raake","year":"2008","journal-title":"Circ Res"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib431","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.freeradbiomed.2007.01.029","article-title":"Systemic adaptation to oxidative challenge induced by regular exercise","volume":"44","author":"Radak","year":"2008","journal-title":"Free Radic Biol Med"},{"issue":"Suppl","key":"10.1016\/j.pharmthera.2010.04.005_bib432","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1038\/ng1798","article-title":"MicroRNA target predictions in animals","volume":"38","author":"Rajewsky","year":"2006","journal-title":"Nat Genet"},{"issue":"22","key":"10.1016\/j.pharmthera.2010.04.005_bib433","doi-asserted-by":"crossref","first-page":"14057","DOI":"10.1074\/jbc.272.22.14057","article-title":"The MEKK-JNK pathway is stimulated by alpha1-adrenergic receptor and ras activation and is associated with in vitro and in vivo cardiac hypertrophy","volume":"272","author":"Ramirez","year":"1997","journal-title":"J Biol Chem"},{"issue":"49","key":"10.1016\/j.pharmthera.2010.04.005_bib434","doi-asserted-by":"crossref","first-page":"31203","DOI":"10.1074\/jbc.272.49.31203","article-title":"The nuclear deltaB isoform of Ca2+\/calmodulin-dependent protein kinase II regulates atrial natriuretic factor gene expression in ventricular myocytes","volume":"272","author":"Ramirez","year":"1997","journal-title":"J Biol Chem"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib435","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1161\/CIRCRESAHA.109.200451","article-title":"Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure","volume":"105","author":"Rao","year":"2009","journal-title":"Circ Res"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib436","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/S0735-1097(01)01433-4","article-title":"Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure-overload cardiac hypertrophy","volume":"38","author":"Rapacciuolo","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib437","doi-asserted-by":"crossref","unstructured":"Regitz-Zagrosek, V. (2006). Therapeutic implications of the gender-specific aspects of cardiovascular disease. Nature Reviews. Drug Discovery 5(5), 425\u2013438.","DOI":"10.1038\/nrd2032"},{"issue":"16","key":"10.1016\/j.pharmthera.2010.04.005_bib438","doi-asserted-by":"crossref","first-page":"8630","DOI":"10.1073\/pnas.93.16.8630","article-title":"Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice","volume":"93","author":"Reiss","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib439","doi-asserted-by":"crossref","first-page":"E876","DOI":"10.1152\/ajpendo.00107.2003","article-title":"Lower skeletal muscle mass in male transgenic mice with muscle-specific overexpression of myostatin","volume":"285","author":"Reisz-Porszasz","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"11","key":"10.1016\/j.pharmthera.2010.04.005_bib440","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1006\/jmcc.1999.1036","article-title":"Insulin-like growth factor I as a cardiac hormone: physiological and pathophysiological implications in heart disease","volume":"31","author":"Ren","year":"1999","journal-title":"J Mol Cell Cardiol"},{"issue":"17","key":"10.1016\/j.pharmthera.2010.04.005_bib441","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1161\/CIRCULATIONAHA.108.814145","article-title":"MicroRNA-320 is involved in the regulation of cardiac ischemia\/reperfusion injury by targeting heat-shock protein 20","volume":"119","author":"Ren","year":"2009","journal-title":"Circulation"},{"issue":"18","key":"10.1016\/j.pharmthera.2010.04.005_bib442","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1161\/01.CIR.0000094397.19932.78","article-title":"Endothelin receptor blockers in cardiovascular disease","volume":"108","author":"Rich","year":"2003","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib443","doi-asserted-by":"crossref","first-page":"H566","DOI":"10.1152\/ajpheart.00562.2008","article-title":"Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase C{beta}2 in the regulation of physiologic developmental hypertrophy and heart function","volume":"296","author":"Rigor","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib444","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.yjmcc.2009.01.013","article-title":"Stimulus specific changes of energy metabolism in hypertrophied heart","volume":"46","author":"Rimbaud","year":"2009","journal-title":"J Mol Cell Cardiol"},{"issue":"26","key":"10.1016\/j.pharmthera.2010.04.005_bib445","doi-asserted-by":"crossref","first-page":"15020","DOI":"10.1073\/pnas.011318098","article-title":"PDK1 regulates growth through Akt and S6K in Drosophila","volume":"98","author":"Rintelen","year":"2001","journal-title":"Proc Nat Acad Sci U S A"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib446","doi-asserted-by":"crossref","first-page":"5097","DOI":"10.1016\/S0021-9258(18)53507-9","article-title":"Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro","volume":"268","author":"Robbins","year":"1993","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib447","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.pharmthera.2009.03.003","article-title":"Significance of peroxisome proliferator-activated receptors in the cardiovascular system in health and disease","volume":"122","author":"Robinson","year":"2009","journal-title":"Pharmacol Ther"},{"issue":"6868","key":"10.1016\/j.pharmthera.2010.04.005_bib448","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/415206a","article-title":"Seven-transmembrane-spanning receptors and heart function","volume":"415","author":"Rockman","year":"2002","journal-title":"Nature"},{"issue":"15","key":"10.1016\/j.pharmthera.2010.04.005_bib449","doi-asserted-by":"crossref","first-page":"6941","DOI":"10.1016\/S0021-9258(18)68584-9","article-title":"Thyroid hormone markedly increases the mRNA coding for sarcoplasmic reticulum Ca2+-ATPase in the rat heart","volume":"263","author":"Rohrer","year":"1988","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.pharmthera.2010.04.005_bib450","doi-asserted-by":"crossref","first-page":"H2264","DOI":"10.1152\/ajpheart.2001.280.5.H2264","article-title":"PKC-beta is not necessary for cardiac hypertrophy","volume":"280","author":"Roman","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"8710","key":"10.1016\/j.pharmthera.2010.04.005_bib451","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0140-6736(90)91812-O","article-title":"Premature mortality due to cardiovascular disease in hypopituitarism","volume":"336","author":"Rosen","year":"1990","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib453","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.cardiores.2004.04.030","article-title":"TGF-beta1 and angiotensin networking in cardiac remodeling","volume":"63","author":"Rosenkranz","year":"2004","journal-title":"Cardiovasc Res"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib454","doi-asserted-by":"crossref","first-page":"H1253","DOI":"10.1152\/ajpheart.00578.2001","article-title":"Alterations of beta-adrenergic signaling and cardiac hypertrophy in transgenic mice overexpressing TGF-beta(1)","volume":"283","author":"Rosenkranz","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib455","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1073\/pnas.041614798","article-title":"Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo","volume":"98","author":"Rothermel","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib456","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.yjmcc.2008.10.021","article-title":"Inducible and cardiac specific PTEN inactivation protects ischemia\/reperfusion injury","volume":"46","author":"Ruan","year":"2009","journal-title":"J Mol Cell Cardiol"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib457","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF01908164","article-title":"The adaptive changes in the isoenzyme pattern of myosin from hypertrophied rat myocardium as a result of pressure overload and physical training","volume":"76","author":"Rupp","year":"1981","journal-title":"Basic Res Cardiol"},{"issue":"1\u20132","key":"10.1016\/j.pharmthera.2010.04.005_bib458","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1023\/A:1025490017780","article-title":"Protein kinase C isoform-selective signals that lead to cardiac hypertrophy and the progression of heart failure","volume":"251","author":"Sabri","year":"2003","journal-title":"Mol Cell Biochem"},{"issue":"12","key":"10.1016\/j.pharmthera.2010.04.005_bib459","doi-asserted-by":"crossref","first-page":"6438","DOI":"10.1073\/pnas.94.12.6438","article-title":"A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program","volume":"94","author":"Sack","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib460","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1161\/01.RES.73.3.413","article-title":"Molecular characterization of angiotensin II-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype","volume":"73","author":"Sadoshima","year":"1993","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib461","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1146\/annurev.physiol.59.1.551","article-title":"The cellular and molecular response of cardiac myocytes to mechanical stress","volume":"59","author":"Sadoshima","year":"1997","journal-title":"Annu Rev Physiol"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib462","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.RES.76.1.1","article-title":"Angiotensin II and other hypertrophic stimuli mediated by G protein-coupled receptors activate tyrosine kinase, mitogen-activated protein kinase, and 90-kD S6 kinase in cardiac myocytes. The critical role of Ca(2+)-dependent signaling","volume":"76","author":"Sadoshima","year":"1995","journal-title":"Circ Res"},{"issue":"4 Suppl","key":"10.1016\/j.pharmthera.2010.04.005_bib463","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S1071-9164(96)80052-2","article-title":"The role of the cardiac renin\u2013angiotensin system in load-induced cardiac hypertrophy","volume":"2","author":"Sadoshima","year":"1996","journal-title":"J Card Fail"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib464","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1172\/JCI0214938","article-title":"The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy","volume":"110","author":"Sadoshima","year":"2002","journal-title":"J Clin Invest"},{"issue":"44","key":"10.1016\/j.pharmthera.2010.04.005_bib465","doi-asserted-by":"crossref","first-page":"34528","DOI":"10.1074\/jbc.M002844200","article-title":"beta-Adrenergic pathway induces apoptosis through calcineurin activation in cardiac myocytes","volume":"275","author":"Saito","year":"2000","journal-title":"J Biol Chem"},{"issue":"9","key":"10.1016\/j.pharmthera.2010.04.005_bib466","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/S0022-2828(03)00234-7","article-title":"Roles of calcineurin and calcium\/calmodulin-dependent protein kinase II in pressure overload-induced cardiac hypertrophy","volume":"35","author":"Saito","year":"2003","journal-title":"J Mol Cell Cardiol"},{"issue":"12","key":"10.1016\/j.pharmthera.2010.04.005_bib467","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1161\/01.RES.0000252345.80198.97","article-title":"Upregulation of heat shock transcription factor 1 plays a critical role in adaptive cardiac hypertrophy","volume":"99","author":"Sakamoto","year":"2006","journal-title":"Circ Res"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib468","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.bbamem.2007.02.010","article-title":"Cardiac GPCRs: GPCR signaling in healthy and failing hearts","volume":"1768","author":"Salazar","year":"2007","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"10.1016\/j.pharmthera.2010.04.005_bib469","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/j.1365-2265.2004.02026.x","article-title":"Left ventricular mass and function in children with GH deficiency before and during 12months GH replacement therapy","volume":"60","author":"Salerno","year":"2004","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib470","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/978-1-4615-4267-4_6","article-title":"Assembly of myofibrils in cardiac muscle cells","volume":"481","author":"Sanger","year":"2000","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib471","doi-asserted-by":"crossref","first-page":"H107","DOI":"10.1152\/ajpheart.00763.2003","article-title":"Influence of cytokines and growth factors in ANG II-mediated collagen upregulation by fibroblasts in rats: role of myocytes","volume":"287","author":"Sarkar","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib472","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00428-007-0532-2","article-title":"MicroRNA \u2014 implications for cancer","volume":"452","author":"Sassen","year":"2008","journal-title":"Virchows Arch"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib473","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1161\/HYPERTENSIONAHA.109.130443","article-title":"Deficiency of nectin-2 leads to cardiac fibrosis and dysfunction under chronic pressure overload","volume":"54","author":"Satomi-Kobayashi","year":"2009","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib474","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1152\/jappl.1979.46.4.854","article-title":"Effects of physical training by running or swimming on ventricular performance of rat hearts","volume":"46","author":"Schaible","year":"1979","journal-title":"J Appl Physiol"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib475","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1152\/jappl.1981.50.6.1140","article-title":"Cardiac function in hypertrophied hearts from chronically exercised female rats","volume":"50","author":"Schaible","year":"1981","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib476","series-title":"Growth of the Heart in Health and Disease","article-title":"Response of the heart to exercise training","author":"Schaible","year":"1984"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib477","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1152\/jappl.1986.60.4.1435","article-title":"Chronic swimming reverses cardiac dysfunction and myosin abnormalities in hypertensive rats","volume":"60","author":"Schaible","year":"1986","journal-title":"J Appl Physiol"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib478","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1096-6374(02)00137-5","article-title":"Short- and long-term swimming exercise training increases myocardial insulin-like growth factor-I gene expression","volume":"13","author":"Scheinowitz","year":"2003","journal-title":"Growth Horm IGF Res"},{"issue":"12A","key":"10.1016\/j.pharmthera.2010.04.005_bib479","doi-asserted-by":"crossref","first-page":"70H","DOI":"10.1016\/S0002-9149(99)00264-7","article-title":"Catecholamines in cardiac hypertrophy","volume":"83","author":"Scheuer","year":"1999","journal-title":"Am J Cardiol"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib480","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1172\/JCI110729","article-title":"Physiologic cardiac hypertrophy corrects contractile protein abnormalities associated with pathologic hypertrophy in rats","volume":"70","author":"Scheuer","year":"1982","journal-title":"J Clin Invest"},{"issue":"11","key":"10.1016\/j.pharmthera.2010.04.005_bib481","doi-asserted-by":"crossref","first-page":"9013","DOI":"10.1074\/jbc.M212923200","article-title":"The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha)","volume":"278","author":"Schreiber","year":"2003","journal-title":"J Biol Chem"},{"issue":"17","key":"10.1016\/j.pharmthera.2010.04.005_bib482","doi-asserted-by":"crossref","first-page":"6472","DOI":"10.1073\/pnas.0308686101","article-title":"The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis","volume":"101","author":"Schreiber","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib483","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1172\/JCI114924","article-title":"Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy. Effects on coronary resistance, contractility, and relaxation","volume":"86","author":"Schunkert","year":"1990","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib484","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1023\/A:1011408425878","article-title":"Clinical experience with endothelin receptor antagonists in chronic heart failure","volume":"6","author":"Seed","year":"2001","journal-title":"Heart Fail Rev"},{"issue":"10","key":"10.1016\/j.pharmthera.2010.04.005_bib485","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1172\/JCI30804","article-title":"A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart","volume":"117","author":"Seguchi","year":"2007","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib486","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1172\/JCI10037","article-title":"Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload","volume":"106","author":"Senbonmatsu","year":"2000","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib487","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1161\/hh0402.105790","article-title":"Cardiac myocyte-specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure","volume":"90","author":"Shai","year":"2002","journal-title":"Circ Res"},{"issue":"14","key":"10.1016\/j.pharmthera.2010.04.005_bib488","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1096\/fj.04-2263com","article-title":"Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart","volume":"18","author":"Sharma","year":"2004","journal-title":"FASEB J"},{"issue":"9","key":"10.1016\/j.pharmthera.2010.04.005_bib489","doi-asserted-by":"crossref","first-page":"5783","DOI":"10.1074\/jbc.272.9.5783","article-title":"Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for myocardial cell hypertrophy","volume":"272","author":"Sheng","year":"1997","journal-title":"J Biol Chem"},{"issue":"24","key":"10.1016\/j.pharmthera.2010.04.005_bib490","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1161\/01.CIR.100.24.2449","article-title":"Calcineurin plays a critical role in pressure overload-induced cardiac hypertrophy","volume":"100","author":"Shimoyama","year":"1999","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.pharmthera.2010.04.005_bib491","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1093\/emboj\/19.11.2537","article-title":"The conserved phosphoinositide 3-kinase pathway determines heart size in mice","volume":"19","author":"Shioi","year":"2000","journal-title":"EMBO J"},{"issue":"8","key":"10.1016\/j.pharmthera.2010.04.005_bib492","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1128\/MCB.22.8.2799-2809.2002","article-title":"Akt\/protein kinase B promotes organ growth in transgenic mice","volume":"22","author":"Shioi","year":"2002","journal-title":"Mol Cell Biol"},{"issue":"12","key":"10.1016\/j.pharmthera.2010.04.005_bib493","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1161\/01.CIR.0000057979.36322.88","article-title":"Rapamycin attenuates load-induced cardiac hypertrophy in mice","volume":"107","author":"Shioi","year":"2003","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.pharmthera.2010.04.005_bib601","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1172\/JCI24682","article-title":"Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure","volume":"115","author":"Shiojima","year":"2005","journal-title":"J Clin Invest"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib494","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1161\/01.RES.0000124394.01180.BE","article-title":"Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes","volume":"94","author":"Shiraishi","year":"2004","journal-title":"Circ Res"},{"issue":"33","key":"10.1016\/j.pharmthera.2010.04.005_bib495","doi-asserted-by":"crossref","first-page":"20555","DOI":"10.1016\/S0021-9258(17)30538-0","article-title":"Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy","volume":"265","author":"Shubeita","year":"1990","journal-title":"J Biol Chem"},{"issue":"9","key":"10.1016\/j.pharmthera.2010.04.005_bib496","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.1210\/jc.2003-030030","article-title":"Effects of one year of recombinant human growth hormone (GH) therapy on cardiac mass and function in children with classical GH deficiency","volume":"88","author":"Shulman","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"5007","key":"10.1016\/j.pharmthera.2010.04.005_bib497","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1126\/science.1902986","article-title":"Diversity of G proteins in signal transduction","volume":"252","author":"Simon","year":"1991","journal-title":"Science"},{"issue":"6803","key":"10.1016\/j.pharmthera.2010.04.005_bib498","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/35035131","article-title":"Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase","volume":"407","author":"Simoncini","year":"2000","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib499","doi-asserted-by":"crossref","first-page":"H469","DOI":"10.1152\/ajpheart.00723.2004","article-title":"Estrogen receptor-beta mediates male\u2013female differences in the development of pressure overload hypertrophy","volume":"288","author":"Skavdahl","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib500","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/cvr\/cvn001","article-title":"Cardiac hypertrophy is enhanced in PPAR alpha\u2212\/\u2212 mice in response to chronic pressure overload","volume":"78","author":"Smeets","year":"2008","journal-title":"Cardiovasc Res"},{"issue":"40","key":"10.1016\/j.pharmthera.2010.04.005_bib501","doi-asserted-by":"crossref","first-page":"26829","DOI":"10.1074\/jbc.R800037200","article-title":"Multiplex kinase signaling modifies cardiac function at the level of sarcomeric proteins","volume":"283","author":"Solaro","year":"2008","journal-title":"J Biol Chem"},{"issue":"10","key":"10.1016\/j.pharmthera.2010.04.005_bib502","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1172\/JCI30335","article-title":"Cardiomyocyte expression of PPARgamma leads to cardiac dysfunction in mice","volume":"117","author":"Son","year":"2007","journal-title":"J Clin Invest"},{"issue":"5 Pt 2","key":"10.1016\/j.pharmthera.2010.04.005_bib503","first-page":"H2183","article-title":"Cardiomyocyte DNA synthesis and binucleation during murine development","volume":"271","author":"Soonpaa","year":"1996","journal-title":"Am J Physiol"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib504","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1385\/CBB:43:1:061","article-title":"Mitogen-activated protein kinases (p38 and c-Jun NH2-terminal kinase) are differentially regulated during cardiac volume and pressure overload hypertrophy","volume":"43","author":"Sopontammarak","year":"2005","journal-title":"Cell Biochem Biophys"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib505","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1083\/jcb.126.4.839","article-title":"Alternative splicing introduces a nuclear localization signal that targets multifunctional CaM kinase to the nucleus","volume":"126","author":"Srinivasan","year":"1994","journal-title":"J Cell Biol"},{"issue":"11","key":"10.1016\/j.pharmthera.2010.04.005_bib506","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1111\/j.1742-4658.2005.04684.x","article-title":"Expression profiling reveals differences in metabolic gene expression between exercise-induced cardiac effects and maladaptive cardiac hypertrophy","volume":"272","author":"Strom","year":"2005","journal-title":"FEBS J"},{"issue":"36","key":"10.1016\/j.pharmthera.2010.04.005_bib507","doi-asserted-by":"crossref","first-page":"24613","DOI":"10.1016\/S0021-9258(18)54273-3","article-title":"Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice","volume":"266","author":"Subramaniam","year":"1991","journal-title":"J Biol Chem"},{"issue":"9","key":"10.1016\/j.pharmthera.2010.04.005_bib508","first-page":"611","article-title":"Signalling pathways in cardiac myocyte hypertrophy","volume":"33","author":"Sugden","year":"2001","journal-title":"Ann Med"},{"issue":"11","key":"10.1016\/j.pharmthera.2010.04.005_bib509","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s001090050275","article-title":"Cellular mechanisms of cardiac hypertrophy","volume":"76","author":"Sugden","year":"1998","journal-title":"J Mol Med"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib510","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1067\/mhj.2003.142","article-title":"Are menstruating women protected from heart disease because of, or in spite of, estrogen? Relevance to the iron hypothesis","volume":"145","author":"Sullivan","year":"2003","journal-title":"Am Heart J"},{"issue":"8131","key":"10.1016\/j.pharmthera.2010.04.005_bib511","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/S0140-6736(79)92010-5","article-title":"Prolongation of survival in congestive cardiomyopathy by beta-receptor blockade","volume":"1","author":"Swedberg","year":"1979","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib512","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1136\/hrt.44.2.117","article-title":"Beneficial effects of long-term beta-blockade in congestive cardiomyopathy","volume":"44","author":"Swedberg","year":"1980","journal-title":"Br Heart J"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib513","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1152\/physrev.1986.66.3.710","article-title":"Developmental and functional adaptation of contractile proteins in cardiac and skeletal muscles","volume":"66","author":"Swynghedauw","year":"1986","journal-title":"Physiol Rev"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib514","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1152\/physrev.1999.79.1.215","article-title":"Molecular mechanisms of myocardial remodeling","volume":"79","author":"Swynghedauw","year":"1999","journal-title":"Physiol Rev"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib515","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.bbrc.2006.03.065","article-title":"JNK1 is required to preserve cardiac function in the early response to pressure overload","volume":"343","author":"Tachibana","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib516","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1073\/pnas.97.3.1196","article-title":"Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy","volume":"97","author":"Taigen","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib517","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.bbrc.2003.10.143","article-title":"Deficit of CD38\/cyclic ADP-ribose is differentially compensated in hearts by gender","volume":"312","author":"Takahashi","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib518","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1161\/HYPERTENSIONAHA.107.088609","article-title":"Pressure overload-induced cardiomyopathy in heterozygous carrier mice of carnitine transporter gene mutation","volume":"50","author":"Takahashi","year":"2007","journal-title":"Hypertension"},{"issue":"12","key":"10.1016\/j.pharmthera.2010.04.005_bib519","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1161\/01.RES.86.12.1218","article-title":"Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy","volume":"86","author":"Takeishi","year":"2000","journal-title":"Circ Res"},{"issue":"9","key":"10.1016\/j.pharmthera.2010.04.005_bib520","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1006\/jmcc.2001.1427","article-title":"Src and multiple MAP kinase activation in cardiac hypertrophy and congestive heart failure under chronic pressure-overload: comparison with acute mechanical stretch","volume":"33","author":"Takeishi","year":"2001","journal-title":"J Mol Cell Cardiol"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib521","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1161\/01.HYP.33.2.676","article-title":"Gender-related differences in myocyte remodeling in progression to heart failure","volume":"33","author":"Tamura","year":"1999","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib522","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1536\/ihj.50.377","article-title":"MicroRNA-1 regulates cardiomyocyte apoptosis by targeting Bcl-2","volume":"50","author":"Tang","year":"2009","journal-title":"Int Heart J"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib523","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.yjmcc.2007.04.004","article-title":"Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy","volume":"42","author":"Tatsuguchi","year":"2007","journal-title":"J Mol Cell Cardiol"},{"issue":"21","key":"10.1016\/j.pharmthera.2010.04.005_bib524","doi-asserted-by":"crossref","first-page":"16302","DOI":"10.1074\/jbc.M001364200","article-title":"Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1","volume":"275","author":"Tcherepanova","year":"2000","journal-title":"J Biol Chem"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib525","doi-asserted-by":"crossref","first-page":"e85","DOI":"10.1161\/CIRCULATIONAHA.105.171600","article-title":"Heart Disease and Stroke Statistics\u20142006 Update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee","volume":"113","author":"Thom","year":"2006","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib526","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1161\/hh0202.104109","article-title":"Adenoviral-directed expression of the type 1A angiotensin receptor promotes cardiomyocyte hypertrophy via transactivation of the epidermal growth factor receptor","volume":"90","author":"Thomas","year":"2002","journal-title":"Circ Res"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib527","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1093\/cvr\/cvn137","article-title":"MicroRNAs: novel regulators in cardiac development and disease","volume":"79","author":"Thum","year":"2008","journal-title":"Cardiovasc Res"},{"issue":"7224","key":"10.1016\/j.pharmthera.2010.04.005_bib528","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/nature07511","article-title":"MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts","volume":"456","author":"Thum","year":"2008","journal-title":"Nature"},{"issue":"30","key":"10.1016\/j.pharmthera.2010.04.005_bib529","doi-asserted-by":"crossref","first-page":"17907","DOI":"10.1016\/S0021-9258(19)84658-6","article-title":"Tissue-specific expression of four types of rat calmodulin-dependent protein kinase II mRNAs","volume":"264","author":"Tobimatsu","year":"1989","journal-title":"J Biol Chem"},{"issue":"6634","key":"10.1016\/j.pharmthera.2010.04.005_bib530","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/42648","article-title":"Signalling through the lipid products of phosphoinositide-3-OH kinase","volume":"387","author":"Toker","year":"1997","journal-title":"Nature"},{"issue":"9254","key":"10.1016\/j.pharmthera.2010.04.005_bib531","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0140-6736(00)04006-X","article-title":"Association between premature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group","volume":"357","author":"Tomlinson","year":"2001","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib532","doi-asserted-by":"crossref","first-page":"H2453","DOI":"10.1152\/ajpheart.00412.2005","article-title":"Measurement of myocardial free radical production during exercise using EPR spectroscopy","volume":"290","author":"Traverse","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib533","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nm1552","article-title":"Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity","volume":"13","author":"Trivedi","year":"2007","journal-title":"Nat Med"},{"issue":"11","key":"10.1016\/j.pharmthera.2010.04.005_bib534","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1111\/j.1440-1681.2008.05037.x","article-title":"Impact of multiple gene mutations in determining the severity of cardiomyopathy and heart failure","volume":"35","author":"Tsoutsman","year":"2008","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"32","key":"10.1016\/j.pharmthera.2010.04.005_bib602","doi-asserted-by":"crossref","first-page":"11946","DOI":"10.1073\/pnas.0510138103","article-title":"Nuclear targeting of Akt antagonizes aspects of cardiomyocyte hypertrophy","volume":"103","author":"Tsujita","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5108","key":"10.1016\/j.pharmthera.2010.04.005_bib535","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1126\/science.8097594","article-title":"Cytoskeletal role in the contractile dysfunction of hypertrophied myocardium","volume":"260","author":"Tsutsui","year":"1993","journal-title":"Science"},{"issue":"5675","key":"10.1016\/j.pharmthera.2010.04.005_bib536","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1126\/science.1096725","article-title":"Hormone therapy: physiological complexity belies therapeutic simplicity","volume":"304","author":"Turgeon","year":"2004","journal-title":"Science"},{"issue":"25","key":"10.1016\/j.pharmthera.2010.04.005_bib537","doi-asserted-by":"crossref","first-page":"23115","DOI":"10.1074\/jbc.M100814200","article-title":"gp130 plays a critical role in pressure overload-induced cardiac hypertrophy","volume":"276","author":"Uozumi","year":"2001","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib538","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1093\/cvr\/cvn282","article-title":"Metabolic remodelling of the failing heart: beneficial or detrimental?","volume":"81","author":"van Bilsen","year":"2009","journal-title":"Cardiovasc Res"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib539","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1152\/physrev.1992.72.4.881","article-title":"Fatty acid homeostasis in the normoxic and ischemic heart","volume":"72","author":"van der Vusse","year":"1992","journal-title":"Physiol Rev"},{"issue":"12","key":"10.1016\/j.pharmthera.2010.04.005_bib540","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1161\/hc3601.095577","article-title":"17beta-estradiol attenuates the development of pressure-overload hypertrophy","volume":"104","author":"van Eickels","year":"2001","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.pharmthera.2010.04.005_bib541","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1172\/JCI33099","article-title":"MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets","volume":"117","author":"van Rooij","year":"2007","journal-title":"J Clin Invest"},{"issue":"48","key":"10.1016\/j.pharmthera.2010.04.005_bib542","doi-asserted-by":"crossref","first-page":"18255","DOI":"10.1073\/pnas.0608791103","article-title":"A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure","volume":"103","author":"van Rooij","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib543","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1006\/excr.1999.4701","article-title":"Signaling by distinct classes of phosphoinositide 3-kinases","volume":"253","author":"Vanhaesebroeck","year":"1999","journal-title":"Experiment Cell Res"},{"issue":"7","key":"10.1016\/j.pharmthera.2010.04.005_bib544","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0968-0004(97)01061-X","article-title":"Phosphoinositide 3-kinases: a conserved family of signal transducers","volume":"22","author":"Vanhaesebroeck","year":"1997","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib545","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1146\/annurev.biochem.70.1.535","article-title":"Synthesis and function of 3-phosphorylated inositol lipids","volume":"70","author":"Vanhaesebroeck","year":"2001","journal-title":"Annu Rev Biochem"},{"issue":"8","key":"10.1016\/j.pharmthera.2010.04.005_bib546","doi-asserted-by":"crossref","first-page":"642","DOI":"10.7326\/0003-4819-139-8-200310210-00007","article-title":"Serum insulin-like growth factor I and risk for heart failure in elderly individuals without a previous myocardial infarction: the Framingham Heart Study","volume":"139","author":"Vasan","year":"2003","journal-title":"Ann Intern Med"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib547","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1073\/pnas.0237225100","article-title":"Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy","volume":"100","author":"Vega","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"10.1016\/j.pharmthera.2010.04.005_bib548","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/70293","article-title":"Cell-autonomous regulation of cell and organ growth in Drosophila by Akt\/PKB","volume":"1","author":"Verdu","year":"1999","journal-title":"Nat Cell Biol"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib549","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/BF00123477","article-title":"The muscle Z band: lessons in stress management","volume":"15","author":"Vigoreaux","year":"1994","journal-title":"J Muscle Res Cell Motil"},{"issue":"6 Pt 2","key":"10.1016\/j.pharmthera.2010.04.005_bib550","first-page":"H1861","article-title":"Cardiac hypertrophy-induced changes in mRNA levels for TGF-beta 1, fibronectin, and collagen","volume":"262","author":"Villarreal","year":"1992","journal-title":"Am J Physiol"},{"issue":"10","key":"10.1016\/j.pharmthera.2010.04.005_bib551","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1136\/hrt.37.10.1022","article-title":"Effect of chronic beta-adrenergic receptor blockade in congestive cardiomyopathy","volume":"37","author":"Waagstein","year":"1975","journal-title":"Br Heart J"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib552","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1161\/01.CIR.80.3.551","article-title":"Long-term beta-blockade in dilated cardiomyopathy. Effects of short- and long-term metoprolol treatment followed by withdrawal and readministration of metoprolol","volume":"80","author":"Waagstein","year":"1989","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.pharmthera.2010.04.005_bib553","first-page":"455","article-title":"Context-specific inhibition of JNKs: overcoming the dilemma of protection and damage","volume":"26","author":"Waetzig","year":"2005","journal-title":"Trends Pharmacol Sci"},{"issue":"17","key":"10.1016\/j.pharmthera.2010.04.005_bib554","doi-asserted-by":"crossref","first-page":"9320","DOI":"10.1073\/pnas.94.17.9320","article-title":"Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy","volume":"94","author":"Wakasaki","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"10.1016\/j.pharmthera.2010.04.005_bib555","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1161\/CIRCULATIONAHA.106.679589","article-title":"Mitogen-activated protein kinases in heart development and diseases","volume":"116","author":"Wang","year":"2007","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.pharmthera.2010.04.005_bib556","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1161\/01.RES.0000041029.97988.E9","article-title":"Ras\/Erk signaling is essential for activation of protein synthesis by Gq protein-coupled receptor agonists in adult cardiomyocytes","volume":"91","author":"Wang","year":"2002","journal-title":"Circ Res"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib557","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1074\/jbc.273.4.2161","article-title":"Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family","volume":"273","author":"Wang","year":"1998","journal-title":"J Biol Chem"},{"issue":"10","key":"10.1016\/j.pharmthera.2010.04.005_bib558","doi-asserted-by":"crossref","first-page":"5423","DOI":"10.1074\/jbc.273.10.5423","article-title":"Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells","volume":"273","author":"Wang","year":"1998","journal-title":"J Biol Chem"},{"issue":"8","key":"10.1016\/j.pharmthera.2010.04.005_bib559","first-page":"2488","article-title":"Monitoring tissue repair and fibrosis from a distance","volume":"96","author":"Weber","year":"1997","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib560","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1161\/01.CIR.83.6.1849","article-title":"Pathological hypertrophy and cardiac interstitium. Fibrosis and renin\u2013angiotensin\u2013aldosterone system","volume":"83","author":"Weber","year":"1991","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib561","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/cvr\/27.3.341","article-title":"Myocardial fibrosis: functional significance and regulatory factors","volume":"27","author":"Weber","year":"1993","journal-title":"Cardiovasc Res"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib562","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0735-1097(99)00165-5","article-title":"Gender differences in molecular remodeling in pressure overload hypertrophy","volume":"34","author":"Weinberg","year":"1999","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib563","doi-asserted-by":"crossref","first-page":"E428","DOI":"10.1152\/ajpendo.00019.2002","article-title":"Thyroid hormone and cardiac function in mice deficient in thyroid hormone receptor-alpha or -beta: an echocardiograph study","volume":"283","author":"Weiss","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib564","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1161\/01.RES.0000013780.77774.75","article-title":"Cardiac-specific IGF-1 expression attenuates dilated cardiomyopathy in tropomodulin-overexpressing transgenic mice","volume":"90","author":"Welch","year":"2002","journal-title":"Circ Res"},{"issue":"10","key":"10.1016\/j.pharmthera.2010.04.005_bib565","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1172\/JCI17664","article-title":"A mechanistic role for cardiac myocyte apoptosis in heart failure","volume":"111","author":"Wencker","year":"2003","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib566","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/00045415-200207000-00005","article-title":"Coronary heart disease and women: magnitude of the problem","volume":"10","author":"Wenger","year":"2002","journal-title":"Cardiol Rev"},{"issue":"11","key":"10.1016\/j.pharmthera.2010.04.005_bib567","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/nm1101-1236","article-title":"Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq\/Galpha11 in cardiomyocytes","volume":"7","author":"Wettschureck","year":"2001","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib568","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1152\/physrev.1999.79.1.143","article-title":"Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human","volume":"79","author":"Widmann","year":"1999","journal-title":"Physiol Rev"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib569","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1161\/01.RES.45.6.697","article-title":"The cardiac hypertrophy process. Analyses of factors determining pathological vs. physiological development","volume":"45","author":"Wikman-Coffelt","year":"1979","journal-title":"Circ Res"},{"issue":"21","key":"10.1016\/j.pharmthera.2010.04.005_bib570","doi-asserted-by":"crossref","first-page":"7603","DOI":"10.1128\/MCB.22.21.7603-7613.2002","article-title":"Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth","volume":"22","author":"Wilkins","year":"2002","journal-title":"Mol Cell Biol"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib571","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1161\/01.RES.0000109415.17511.18","article-title":"Calcineurin\/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy","volume":"94","author":"Wilkins","year":"2004","journal-title":"Circ Res"},{"issue":"44","key":"10.1016\/j.pharmthera.2010.04.005_bib572","doi-asserted-by":"crossref","first-page":"27696","DOI":"10.1074\/jbc.271.44.27696","article-title":"Crystal structure of p38 mitogen-activated protein kinase","volume":"271","author":"Wilson","year":"1996","journal-title":"J Biol Chem"},{"issue":"16","key":"10.1016\/j.pharmthera.2010.04.005_bib573","doi-asserted-by":"crossref","first-page":"9535","DOI":"10.1074\/jbc.271.16.9535","article-title":"Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series VIA gp130\/leukemia inhibitory factor receptor-dependent pathways","volume":"271","author":"Wollert","year":"1996","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib574","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1093\/cvr\/cvm078","article-title":"Cardiac alpha 1-adrenergic drive in pathological remodelling","volume":"77","author":"Woodcock","year":"2008","journal-title":"Cardiovasc Res"},{"issue":"11","key":"10.1016\/j.pharmthera.2010.04.005_bib575","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/j.0305-1870.2004.04073.x","article-title":"Cardioprotective functions of atrial natriuretic peptide and B-type natriuretic peptide: a brief review","volume":"31","author":"Woods","year":"2004","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"12","key":"10.1016\/j.pharmthera.2010.04.005_bib576","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1161\/hh2401.100427","article-title":"Increased myocardial Rab GTPase expression: a consequence and cause of cardiomyopathy","volume":"89","author":"Wu","year":"2001","journal-title":"Circ Res"},{"issue":"5625","key":"10.1016\/j.pharmthera.2010.04.005_bib577","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1126\/science.1079206","article-title":"Myocyte adrenoceptor signaling pathways","volume":"300","author":"Xiang","year":"2003","journal-title":"Science"},{"issue":"6878","key":"10.1016\/j.pharmthera.2010.04.005_bib578","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/416334a","article-title":"Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy","volume":"416","author":"Xin","year":"2002","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib579","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S0008-6363(02)00705-8","article-title":"Estrogen modulation of left ventricular remodeling in the aged heart","volume":"57","author":"Xu","year":"2003","journal-title":"Cardiovasc Res"},{"issue":"10","key":"10.1016\/j.pharmthera.2010.04.005_bib580","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1172\/JCI17459","article-title":"Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy","volume":"111","author":"Yamamoto","year":"2003","journal-title":"J Clin Invest"},{"issue":"5","key":"10.1016\/j.pharmthera.2010.04.005_bib581","first-page":"639","article-title":"Is there major involvement of the renin\u2013angiotensin system in cardiac hypertrophy?","volume":"81","author":"Yamazaki","year":"1997","journal-title":"Circ Res"},{"issue":"16","key":"10.1016\/j.pharmthera.2010.04.005_bib582","doi-asserted-by":"crossref","first-page":"12069","DOI":"10.1016\/S0021-9258(19)50309-X","article-title":"Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes","volume":"268","author":"Yamazaki","year":"1993","journal-title":"J Biol Chem"},{"issue":"12A","key":"10.1016\/j.pharmthera.2010.04.005_bib583","doi-asserted-by":"crossref","first-page":"53H","DOI":"10.1016\/S0002-9149(99)00259-3","article-title":"Role of the renin\u2013angiotensin system in cardiac hypertrophy","volume":"83","author":"Yamazaki","year":"1999","journal-title":"Am J Cardiol"},{"issue":"25","key":"10.1016\/j.pharmthera.2010.04.005_bib584","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1161\/01.CIR.102.25.3046","article-title":"Decreased SLIM1 expression and increased gelsolin expression in failing human hearts measured by high-density oligonucleotide arrays","volume":"102","author":"Yang","year":"2000","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib585","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1124\/jpet.103.058420","article-title":"Up-regulation of angiotensin II type 2 receptor in rat thoracic aorta by pressure-overload","volume":"308","author":"Yayama","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"issue":"1 Pt 1","key":"10.1016\/j.pharmthera.2010.04.005_bib586","first-page":"E129","article-title":"Effect of growth hormone administration and treadmill exercise on serum and skeletal IGF-I in rats","volume":"266","author":"Yeh","year":"1994","journal-title":"Am J Physiol"},{"issue":"suppl II","key":"10.1016\/j.pharmthera.2010.04.005_bib587","first-page":"17","article-title":"Development and proliferative capacity of cardiac muscle cells","volume":"35","author":"Zak","year":"1974","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib588","unstructured":"Zak, R. (1984). Growth of the heart in health and disease. New York, Raven Press: 1\u201324, 131\u2013185, 381\u2013420"},{"issue":"3","key":"10.1016\/j.pharmthera.2010.04.005_bib589","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S0735-1097(98)00634-2","article-title":"Incidence, clinical and etiologic features, and outcomes of advanced chronic heart failure: the EPICAL Study. Epidemiologie de l'Insuffisance Cardiaque Avancee en Lorraine","volume":"33","author":"Zannad","year":"1999","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"10.1016\/j.pharmthera.2010.04.005_bib590","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm1613","article-title":"Endothelial-to-mesenchymal transition contributes to cardiac fibrosis","volume":"13","author":"Zeisberg","year":"2007","journal-title":"Nat Med"},{"issue":"45","key":"10.1016\/j.pharmthera.2010.04.005_bib591","doi-asserted-by":"crossref","first-page":"33181","DOI":"10.1074\/jbc.M705133200","article-title":"Glycogen synthase kinase-3alpha reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal-regulated kinases","volume":"282","author":"Zhai","year":"2007","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib592","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0092-8674(02)00861-9","article-title":"Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy","volume":"110","author":"Zhang","year":"2002","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.pharmthera.2010.04.005_bib593","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1074\/jbc.M108525200","article-title":"The cardiac-specific nuclear delta(B) isoform of Ca2+\/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity","volume":"277","author":"Zhang","year":"2002","journal-title":"J Biol Chem"},{"issue":"6","key":"10.1016\/j.pharmthera.2010.04.005_bib594","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1172\/JCI16290","article-title":"The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis","volume":"111","author":"Zhang","year":"2003","journal-title":"J Clin Invest"},{"issue":"8","key":"10.1016\/j.pharmthera.2010.04.005_bib595","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1161\/01.RES.0000069686.31472.C5","article-title":"The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure","volume":"92","author":"Zhang","year":"2003","journal-title":"Circ Res"},{"issue":"4","key":"10.1016\/j.pharmthera.2010.04.005_bib596","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nm1215","article-title":"Calmodulin kinase II inhibition protects against structural heart disease","volume":"11","author":"Zhang","year":"2005","journal-title":"Nat Med"},{"issue":"3A","key":"10.1016\/j.pharmthera.2010.04.005_bib597","doi-asserted-by":"crossref","first-page":"110A","DOI":"10.1016\/S0002-9149(97)00465-7","article-title":"Effects of angiotensin-converting enzyme inhibition and angiotensin II AT1 receptor antagonism on cardiac parameters in left ventricular hypertrophy","volume":"80","author":"Zhu","year":"1997","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib598","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1146\/annurev.pharmtox.37.1.53","article-title":"Tissue renin\u2013angiotensin system: a site of drug action?","volume":"37","author":"Zimmerman","year":"1997","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.pharmthera.2010.04.005_bib599","series-title":"Braunwald's Heart Disease: a Textbook Of Cardiovascular Medicine Seventh Edition","author":"Zipes","year":"2005"},{"issue":"1","key":"10.1016\/j.pharmthera.2010.04.005_bib600","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1161\/01.CIR.104.1.97","article-title":"Calcineurin plays a critical role in the development of pressure overload-induced cardiac hypertrophy","volume":"104","author":"Zou","year":"2001","journal-title":"Circulation"}],"container-title":["Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725810000793?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725810000793?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T13:49:50Z","timestamp":1740059390000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725810000793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":600,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0163725810000793"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2010.04.005","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}