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beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production","volume":"278","author":"Grbovic","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2011.03.004_bb0450","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/ng1742","article-title":"ANG mutations segregate with familial and \u2018sporadic\u2019 amyotrophic lateral sclerosis","volume":"38","author":"Greenway","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.pharmthera.2011.03.004_bb0455","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1083\/jcb.148.5.945","article-title":"Dynein-mediated cargo transport in vivo. A switch controls travel distance","volume":"148","author":"Gross","year":"2000","journal-title":"J Cell Biol"},{"key":"10.1016\/j.pharmthera.2011.03.004_bb0460","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0896-6273(03)00594-4","article-title":"Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila","volume":"40","author":"Gunawardena","year":"2003","journal-title":"Neuron"},{"issue":"Suppl. 2","key":"10.1016\/j.pharmthera.2011.03.004_bb0465","first-page":"S3","article-title":"What causes cell death in Parkinson's disease?","volume":"64","author":"Gupta","year":"2008","journal-title":"Ann Neurol"},{"key":"10.1016\/j.pharmthera.2011.03.004_bb0470","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/hmg\/ddi440","article-title":"Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2\/alsin exhibit age-dependent neurological deficits and altered endosome 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disease","volume":"68","author":"Hirokawa","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.pharmthera.2011.03.004_bb0520","doi-asserted-by":"crossref","first-page":"5411","DOI":"10.1242\/jcs.02745","article-title":"The axonal transport of mitochondria","volume":"118","author":"Hollenbeck","year":"2005","journal-title":"J Cell Sci"},{"key":"10.1016\/j.pharmthera.2011.03.004_bb0525","doi-asserted-by":"crossref","first-page":"36598","DOI":"10.1074\/jbc.M104838200","article-title":"Beta III spectrin binds to the Arp1 subunit of dynactin","volume":"276","author":"Holleran","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2011.03.004_bb0530","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1146\/annurev.cb.10.110194.002011","article-title":"DYNEINS: molecular structure and cellular function","volume":"10","author":"Holzbaur","year":"1994","journal-title":"Annu Rev Cell 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dynein motor","volume":"2","author":"King","year":"2000","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.pharmthera.2011.03.004_bb0640","doi-asserted-by":"crossref","first-page":"15033","DOI":"10.1021\/bi9810813","article-title":"Cytoplasmic dynein contains a family of differentially expressed light chains","volume":"37","author":"King","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.pharmthera.2011.03.004_bb0645","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1001\/archneurol.2010.40","article-title":"Clearance of mutant proteins as a therapeutic target in neurodegenerative diseases","volume":"67","author":"Krainc","year":"2010","journal-title":"Arch Neurol"},{"key":"10.1016\/j.pharmthera.2011.03.004_bb0650","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1001\/archneur.65.9.1185","article-title":"Two German kindreds with familial amyotrophic lateral sclerosis due to TARDBP 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Biol"},{"key":"10.1016\/j.pharmthera.2011.03.004_bb1015","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1016\/j.cub.2006.09.014","article-title":"Microtubule acetylation promotes kinesin-1 binding and transport","volume":"16","author":"Reed","year":"2006","journal-title":"Curr Biol"},{"key":"10.1016\/j.pharmthera.2011.03.004_bb1020","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neuron.2009.06.021","article-title":"Activity-dependent regulation of synapses by retrograde messengers","volume":"63","author":"Regehr","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.pharmthera.2011.03.004_bb1025","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.expneurol.2009.08.010","article-title":"Retrograde signaling in axonal regeneration","volume":"223","author":"Rishal","year":"2010","journal-title":"Exp 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