{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:39:06Z","timestamp":1790861946978,"version":"4.1.0"},"reference-count":261,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.pharmthera.2011.10.004","type":"journal-article","created":{"date-parts":[[2011,10,31]],"date-time":"2011-10-31T16:11:39Z","timestamp":1320077499000},"page":"159-176","source":"Crossref","is-referenced-by-count":187,"title":["Age-related changes in endothelial function and blood flow regulation"],"prefix":"10.1016","volume":"133","author":[{"given":"Noboru","family":"Toda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharmthera.2011.10.004_bb0005","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1439-0272.2009.00977.x","article-title":"Effect of mesenchymal stem cell penile transplantation on erectile signaling of aged rats","volume":"42","author":"Abdel Aziz","year":"2010","journal-title":"Andrologia"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0010","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/00004872-200402000-00016","article-title":"An age-related decline in endothelial function is not associated with alterations in L-arginine transport in humans","volume":"22","author":"Ahlers","year":"2004","journal-title":"J Hypertens"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0015","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ijcard.2005.06.002","article-title":"Effects of aging and atherosclerosis on endothelial and vascular smooth muscle function in humans","volume":"109","author":"Al-Shaer","year":"2006","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0020","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/jhh.2009.58","article-title":"DASH lowers blood pressure in obese hypertensives beyond potassium, magnesium and fibre","volume":"24","author":"Al-Solaiman","year":"2010","journal-title":"J Hum Hypertens"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0025","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1046\/j.1365-201X.1996.451171000.x","article-title":"Ageing is associated with reduced basal and stimulated release of nitric oxide by the coronary endothelium","volume":"157","author":"Amrani","year":"1996","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0030","first-page":"H1259","article-title":"Age-associated impairment in vasorelaxation to fluid shear stress in the female vasculature is improved by TNF-\u03b1 antagonism","volume":"290","author":"Arenas","year":"2006","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0035","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1161\/01.RES.0000070067.64040.7C","article-title":"HMG-CoA reductase inhibitors reduce senescence and increase proliferation of endothelial progenitor cells via regulation of cell cycle regulatory genes","volume":"92","author":"Assmus","year":"2003","journal-title":"Circ Res"},{"issue":"Suppl. 1","key":"10.1016\/j.pharmthera.2011.10.004_bb0040","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1038\/sj.cdd.4401451","article-title":"Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease","volume":"11","author":"Austin","year":"2004","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0045","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1161\/CIRCRESAHA.110.233080","article-title":"Endothelial nitric oxide modulates expression and processing of amyloid precursor protein","volume":"107","author":"Austin","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0050","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0021-9150(01)00506-8","article-title":"Age dependent aneuploidy and telomere length of the human vascular endothelium","volume":"159","author":"Aviv","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0055","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1172\/JCI118181","article-title":"Cyclic strain upregulates nitric oxide synthase in cultured bovine aortic endothelial cells","volume":"96","author":"Awolesi","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0060","first-page":"441","article-title":"Telomere shortening & metabolic\/vascular diseases","volume":"125","author":"Balasubramanyam","year":"2007","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0065","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1093\/eurheartj\/ehl202","article-title":"Circulating endothelial progenitor cells correlate with erectile function in patients with coronary heart disease","volume":"27","author":"Baumh\u00e4kel","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0070","first-page":"R1274","article-title":"Advancing age produces sex differences in vasomotor kinetics during and after skeletal muscle contraction","volume":"293","author":"Bearden","year":"2007","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0075","doi-asserted-by":"crossref","first-page":"30707","DOI":"10.1074\/jbc.M005116200","article-title":"Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric-oxide synthase","volume":"275","author":"Bernier","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0080","first-page":"H1408","article-title":"Gene transfer of extracellular SOD to the penis reduces O2- and improves erectile function in aged rats","volume":"284","author":"Bivalacqua","year":"2003","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0085","first-page":"H1340","article-title":"Overexpression of arginase in the aged mouse penis impairs erectile function and decreases eNOS activity: influence of in vivo gene therapy of anti-arginase","volume":"292","author":"Bivalacqua","year":"2007","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0090","first-page":"H1278","article-title":"Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age-associated erectile dysfunction","volume":"292","author":"Bivalacqua","year":"2007","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0095","first-page":"H1109","article-title":"Impact of age, sex, and exercise on brachial artery flow-mediated dilatation","volume":"297","author":"Black","year":"2009","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0100","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1191\/1358863x03vm474oa","article-title":"Oral L-arginine improves endothelial function in healthy individuals older than 70 years","volume":"8","author":"Bode-B\u00f6ger","year":"2003","journal-title":"Vasc Med"},{"issue":"Suppl. 1","key":"10.1016\/j.pharmthera.2011.10.004_bb0105","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1177\/1358836X0501000110","article-title":"Asymmetric dimethylarginine (ADMA) accelerates cell senescence","volume":"10","author":"Bode-B\u00f6ger","year":"2005","journal-title":"Vasc Med"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0110","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1076\/apab.111.1.23.15138","article-title":"Mechanisms underlying the programming of small artery dysfunction: review of the model using low protein diet in pregnancy in the rat","volume":"111","author":"Brawley","year":"2003","journal-title":"Arch Physiol Biochem"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0115","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.niox.2009.10.001","article-title":"Plasma nitrate\/nitrite levels are unchanged after long-term aerobic exercise training in older adults","volume":"21","author":"Brinkley","year":"2009","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0120","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1179\/016164103101202066","article-title":"Progenitor endothelial cell involvement in Alzheimer's disease","volume":"25","author":"Budinger","year":"2003","journal-title":"Neurol Res"},{"issue":"12 Suppl 4","key":"10.1016\/j.pharmthera.2011.10.004_bb0125","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1524-6175.2006.06026.x","article-title":"The role of nitric oxide in erectile dysfunction: implications for medical therapy","volume":"8","author":"Burnett","year":"2006","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0130","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s11906-999-0078-6","article-title":"Nitric oxide, nitric oxide synthase, and hypertensive vascular disease","volume":"1","author":"Busse","year":"1999","journal-title":"Curr Hypertens Rep"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0135","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1210\/er.22.1.36","article-title":"Diabetes and endothelial dysfunction: a clinical perspective","volume":"22","author":"Calles-Escandon","year":"2001","journal-title":"Endocr Rev"},{"issue":"11 Suppl Proceedings","key":"10.1016\/j.pharmthera.2011.10.004_bb0140","first-page":"108","article-title":"Erectile dysfunction in aging men: testosterone role in therapeutic protocols","volume":"28","author":"Caretta","year":"2005","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0145","doi-asserted-by":"crossref","first-page":"11190","DOI":"10.1073\/pnas.92.24.11190","article-title":"Telomere length and replicative aging in human vascular tissues","volume":"92","author":"Chang","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0150","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1161\/CIRCULATIONAHA.107.715847","article-title":"Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1\u03b1 stabilization during ischemia","volume":"116","author":"Chang","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0155","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1152\/japplphysiol.00298.2010","article-title":"Mechanisms and modifiers of reflex induced cutaneous vasodilation and vasoconstriction in humans","volume":"109","author":"Charkoudian","year":"2010","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0160","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1161\/CIRCULATIONAHA.109.909218","article-title":"Exercise training stimulates ischemia-induced neovascularization via phosphatidylinositol 3-kinase\/Akt dependent hypoxia-induced factor-1\u03b1 reactivation in mice of advanced age","volume":"122","author":"Cheng","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0165","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.molmed.2008.09.003","article-title":"The role of oxidative stress and NADPH oxidase in cerebrovascular disease","volume":"14","author":"Chrissobolis","year":"2008","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0170","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1073\/pnas.0400266101","article-title":"Cardiovascular fitness, cortical plasticity, and aging","volume":"101","author":"Colcombe","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0175","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s11906-001-0085-8","article-title":"Effects of blood pressure and glucose on endothelial function","volume":"3","author":"Cosentino","year":"2001","journal-title":"Curr Hypertens Rep"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0180","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.mad.2009.06.004","article-title":"Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1","volume":"130","author":"Csiszar","year":"2009","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0185","doi-asserted-by":"crossref","first-page":"388","DOI":"10.2353\/ajpath.2007.060708","article-title":"Vasculoprotective effects of anti-tumor necrosis factor-\u03b1 treatment in aging","volume":"170","author":"Csiszar","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0190","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1161\/01.RES.0000020401.61826.EA","article-title":"Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function","volume":"90","author":"Csiszar","year":"2002","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0195","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1152\/japplphysiol.90470.2008","article-title":"Inflammation and endothelial dysfunction during aging: role of NF-\u03baB","volume":"105","author":"Csiszar","year":"2008","journal-title":"J Appl Physiol"},{"issue":"23 Suppl 1","key":"10.1016\/j.pharmthera.2011.10.004_bb0200","first-page":"III39","article-title":"Beneficial cardiovascular pleiotropic effects of statins","volume":"109","author":"Davignon","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0205","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/sj.jcbfm.9600057","article-title":"Inhibition of vascular nitric oxide after rat chronic brain hypoperfusion: special memory and immunocytochemical changes","volume":"25","author":"de la Torre","year":"2005","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0210","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1097\/FJC.0b013e31812564e4","article-title":"Therapeutic effects of autologous bone marrow cells and metabolic intervention in the ischemic hindlimb of spontaneously hypertensive rats involve reduced cell senescence and CXCR4\/Akt\/eNOS pathway","volume":"50","author":"de Nigris","year":"2007","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0215","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1113\/jphysiol.2007.147686","article-title":"Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles","volume":"586","author":"Delp","year":"2008","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0220","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1161\/01.CIR.102.12.1351","article-title":"Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation healthy men","volume":"102","author":"DeSouza","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0225","doi-asserted-by":"crossref","first-page":"797","DOI":"10.2165\/11317750-000000000-00000","article-title":"The effect of physical exercise on endothelial function","volume":"39","author":"Di Francescomarino","year":"2009","journal-title":"Sports Med"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0230","first-page":"13","article-title":"Possible involvement of increased susceptibility of LDL to oxidation in age-related platelet activation","volume":"25","author":"Di Massimo","year":"2001","journal-title":"Clin Hemorheol Microcirc"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0240","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1172\/JCI200113152","article-title":"HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cellos via PI3-kinase\/Akt pathway","volume":"108","author":"Dimmeler","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0245","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/21224","article-title":"Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation","volume":"399","author":"Dimmeler","year":"1999","journal-title":"Nature (Lond)"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0235","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/sj.cdd.4400581","article-title":"Nitric oxide\u2014an endothelial cell survival factor","volume":"6","author":"Dimmeler","year":"1999","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0250","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.amjcard.2009.09.038","article-title":"Effect of intensive lifestyle changes on endothelial function and on inflammatory markers of atherosclerosis","volume":"105","author":"Dod","year":"2010","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0255","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s12035-010-8104-x","article-title":"Cyclic GMP and nitric oxide synthase in aging and Alzheimer's disease","volume":"41","author":"Domek-Lopaci\u0144ska","year":"2010","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0260","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.bone.2009.10.029","article-title":"Increased nitric oxide-mediated vasodilation of bone resistance arteries is associated with increased trabecular bone volume after endurance training in rats","volume":"46","author":"Dominguez","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0265","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/j.1474-9726.2008.00438.x","article-title":"Aging is associated with greater nuclear NF\u03baB, reduced I\u03baB\u03b1, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans","volume":"7","author":"Donato","year":"2008","journal-title":"Aging Cell"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0270","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1152\/japplphysiol.90629.2008","article-title":"Cytochrome P-450 2C9 signaling does not contribute to age-associated vascular endothelial dysfunction in humans","volume":"105","author":"Donato","year":"2008","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0275","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1161\/01.RES.0000269183.13937.e8","article-title":"Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregualtion of nuclear factor-\u03baB","volume":"100","author":"Donato","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0280","first-page":"H425","article-title":"Vascular endothelial dysfunction with aging: endothelin-1 and endothelial nitric oxide synthase","volume":"297","author":"Donato","year":"2009","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0285","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1113\/jphysiol.2006.120055","article-title":"Ageing and exercise training alter adrenergic vasomotor responses of rat skeletal muscle arterioles","volume":"579","author":"Donato","year":"2007","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0290","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/FJC.0b013e31802ef519","article-title":"Ginkgo biloba extract reduces endothelial progenitor cell senescence through augmentation of telomerase activity","volume":"49","author":"Dong","year":"2007","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0295","doi-asserted-by":"crossref","first-page":"E89","DOI":"10.1161\/01.RES.0000020861.20064.7E","article-title":"Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function","volume":"90","author":"Edelberg","year":"2002","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0300","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.neubiorev.2005.10.004","article-title":"Exercise, cognition and Alzheimer's disease: more is not necessarily better","volume":"30","author":"Eggermont","year":"2006","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0305","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1743-6109.2008.01042.x","article-title":"Circulating CD34+ KDR+ endothelial progenitor cells correlated with erectile function and endothelial function in overweight men","volume":"6","author":"Esposito","year":"2009","journal-title":"J Sex Med"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0310","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1074\/jbc.273.50.33472","article-title":"Protein inhibitor of neuronal nitric-oxide synthase, PIN, binds to a 17-amino acid residue fragment of the enzyme","volume":"273","author":"Fan","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0315","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1095\/biolreprod.106.059642","article-title":"Long-term continuous treatment with sildenafil ameliorates aging-related erectile dysfunction and the underlying corporal fibrosis in the rat","volume":"76","author":"Ferrini","year":"2007","journal-title":"Biol Reprod"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0320","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1097\/01.hjh.0000239293.40507.2a","article-title":"Aging and vascular responses to flavanol-rich cocoa","volume":"24","author":"Fisher","year":"2006","journal-title":"J Hypertens"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0325","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/ncpcardio1211","article-title":"Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies","volume":"5","author":"F\u00f6rstermann","year":"2008","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0330","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.neuint.2004.03.026","article-title":"Effect of hypercholesterolemia and of oxidative stress on the nitric oxide-cGMP pathway","volume":"45","author":"Francois","year":"2004","journal-title":"Neurochem Int"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0335","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1042\/CS20030229","article-title":"Effects of age and physical fitness on microcirculatory function","volume":"106","author":"Franzoni","year":"2004","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0340","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/HJH.0b013e32833db36e","article-title":"Heme oxygenase-1 induction restores high-blood-flow dependent remodeling and endothelial function in mesenteric arteries of old rats","volume":"29","author":"Freidja","year":"2011","journal-title":"J Hypertens"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0345","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/S0024-3205(98)00351-8","article-title":"Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress","volume":"63","author":"Furumoto","year":"1998","journal-title":"Life Sci"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0350","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.biopha.2006.07.013","article-title":"Ambulatory blood pressure monitoring and endothelium-dependent vasodilation in the elderly athletes","volume":"60","author":"Galetta","year":"2006","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0355","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1439-0272.2007.00782.x","article-title":"Y-27632 improves the erectile dysfunction with ageing in SD rats through adjusting the imbalance between nNO and the Rho-kinase pathways","volume":"39","author":"Gao","year":"2007","journal-title":"Andrologia"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0360","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1152\/japplphysiol.00660.2006","article-title":"Impaired flow-mediated dilation with age is not explained by L-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression","volume":"102","author":"Gates","year":"2007","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0365","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1152\/japplphysiol.00275.2003","article-title":"Selected contribution: effects of aging on cerebrovascular tone and [Ca2+]i","volume":"95","author":"Geary","year":"2003","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0370","first-page":"R734","article-title":"Maturation depresses mouse cerebrovascular tone through endothelium-dependent mechanisms","volume":"284","author":"Geary","year":"2003","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0375","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.atherosclerosis.2006.06.026","article-title":"The PPAR-\u03b3 agonist pioglitazone increases neoangiogenesis and prevents apoptosis of endothelial progenitor cells","volume":"192","author":"Gensch","year":"2007","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0380","doi-asserted-by":"crossref","first-page":"48135","DOI":"10.1074\/jbc.M407358200","article-title":"Mechanisms of soluble \u03b2-amyloid impairment of endothelial function","volume":"279","author":"Gentile","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0385","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1161\/01.HYP.27.4.849","article-title":"Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans","volume":"27","author":"Gerhard","year":"1996","journal-title":"Hypertension"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0390","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.cardiores.2007.05.021","article-title":"Age decreases nitric oxide synthesis and responsiveness in human platelets and increases formation of monocyte-platelet aggregates","volume":"75","author":"Goubareva","year":"2007","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0395","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.2004.068197","article-title":"Effect of exercise training on endothelium-derived nitric oxide function in humans","volume":"561","author":"Green","year":"2004","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0400","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1016\/j.febslet.2007.05.010","article-title":"Outgrowing endothelial progenitor-derived cells display high sensitivity to angiogenesis modulators and delayed senescence","volume":"581","author":"Ha","year":"2007","journal-title":"FEBS Lett"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0405","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1113\/expphysiol.2007.038729","article-title":"Oxidative stress and cerebrovascular dysfunction in mouse models of Alzheimer's disease","volume":"93","author":"Hamel","year":"2008","journal-title":"Exp Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0410","doi-asserted-by":"crossref","first-page":"3373","DOI":"10.1111\/j.1743-6109.2010.01920.x","article-title":"Morphological and functional evidence for the contribution of the pudendal artery in aging-induced erectile dysfunction","volume":"7","author":"Hannan","year":"2010","journal-title":"J Sex Med"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0415","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1749-6632.2000.tb06389.x","article-title":"\u03b2-Amyloid excitotoxicity in rat magnocellular nucleus basalis. Effects of cortical deafferentation on cerebral blood flow regulation and implications for Alzheimer's disease","volume":"903","author":"Harkany","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0420","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1365-2184.2004.00315.x","article-title":"Telomere attrition and accumulation of senescent cells in cultured human endothelial cells","volume":"37","author":"Hastings","year":"2004","journal-title":"Cell Prolif"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0425","doi-asserted-by":"crossref","first-page":"17018","DOI":"10.1073\/pnas.0607873103","article-title":"Endothelial cellular senescence is inhibited by nitric oxide: implications in atherosclerosis associated with menopause and diabetes","volume":"103","author":"Hayashi","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0430","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.mvr.2009.08.009","article-title":"Aging decreases expression and activity of glutathione peroxidase-1 in human endothelial progenitor cells","volume":"78","author":"He","year":"2009","journal-title":"Microvasc Res"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0435","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.jacc.2004.12.074","article-title":"Impaired progenitor cell activity in age-related endothelial dysfunction","volume":"45","author":"Heiss","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0440","first-page":"H1086","article-title":"In vivo measurement of flow-mediated vasodilation in living rat using high-resolution ultrasound","volume":"294","author":"Heiss","year":"2008","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0445","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.atherosclerosis.2005.07.025","article-title":"Tetrahydrobiopterin improves aging-related impairment of endothelium-dependent vasodilation through increase in nitric oxide production","volume":"186","author":"Higashi","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0450","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1056\/NEJMoa022287","article-title":"Circulating endothelial progenitor cells, vascular function, and cardiovascular risk","volume":"348","author":"Hill","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0455","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/(SICI)1097-4644(19991101)75:2<258::AID-JCB8>3.0.CO;2-3","article-title":"Nitric oxide prevents apoptosis of human endothelial cells from high glucose exposure during early stage","volume":"75","author":"Ho","year":"1999","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0460","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1152\/japplphysiol.01183.2006","article-title":"Aging, exercise, and endothelial progenitor cell clonogenic and migratory capacity in men","volume":"102","author":"Hoetzer","year":"2007","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0465","first-page":"H1662","article-title":"Nitric oxide and attenuated reflex cutaneous vasodilation in aged skin","volume":"284","author":"Holowatz","year":"2003","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0470","first-page":"H2965","article-title":"Acute ascorbate supplementation alone or combined with arginase inhibition augments reflex cutaneous vasodilation in aged human skin","volume":"291","author":"Holowatz","year":"2006","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0475","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1113\/jphysiol.2004.080952","article-title":"Mechanisms of acetylcholine-mediated vasodilatation in young and aged human skin","volume":"563","author":"Holowatz","year":"2005","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0480","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.atherosclerosis.2008.12.036","article-title":"Telmisartan induces proliferation of human endothelial progenitor cells via PPAR\u03b3-dependent PI3K\/Akt pathway","volume":"205","author":"Honda","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0485","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.exger.2007.01.007","article-title":"Evidence against the involvement of nitric oxide in the modulation of telomerase activity or replicative capacity of human endothelial cells","volume":"42","author":"Hong","year":"2007","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0490","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.cellbi.2008.03.004","article-title":"Low-dose aspirin promotes endothelial progenitor cell migration and adhesion and prevents senescence","volume":"32","author":"Hu","year":"2008","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0495","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1161\/ATVBAHA.109.200618","article-title":"Intake of red wine increases the number and functional capacity of circulating endothelial progenitor cells by enhancing nitric oxide bioavailability","volume":"30","author":"Huang","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0500","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1291\/hypres.28.263","article-title":"Estrogen reduces angiotensin II-induced acceleration of senescence in endothelial progenitor cells","volume":"28","author":"Imanishi","year":"2005","journal-title":"Hypertens Res"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0505","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1291\/hypres.28.763","article-title":"Effect of estrogen on differentiation and senescence in endothelial progenitor cells derived from bone marrow in spontaneously hypertensive rats","volume":"28","author":"Imanishi","year":"2005","journal-title":"Hypertens Res"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0510","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1291\/hypres.31.757","article-title":"Pioglitazone inhibits angiotensin II-induced senescence of endothelial progenitor cell","volume":"31","author":"Imanishi","year":"2008","journal-title":"Hypertens Res"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0515","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1097\/01.hjh.0000183524.73746.1b","article-title":"Endothelial progenitor cell senescence is accelerated in both experimental hypertensive rats and patients with essential hypertension","volume":"23","author":"Imanishi","year":"2005","journal-title":"J Hypertens"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0520","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1161\/ATVBAHA.107.155390","article-title":"Blocking thrombospondin-1\/CD47 signaling alleviates deleterious effects of aging on tissue responses to ischemia","volume":"27","author":"Isenberg","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0525","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/S0026-895X(24)26508-1","article-title":"Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases","volume":"57","author":"Ishizaki","year":"2000","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0530","first-page":"46","article-title":"Endothelial dysfunction: a potential therapeutic target for geriatric depression and brain amyloid deposition in Alzheimer's disease?","volume":"10","author":"Isingrini","year":"2009","journal-title":"Curr Opin Investig Drugs"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0535","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1126\/science.274.5288.774","article-title":"PIN: an associated protein inhibitor of neuronal nitric oxide synthase","volume":"274","author":"Jaffrey","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0540","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.mvr.2009.05.004","article-title":"Wavelet analysis of sacral skin blood flow oscillations to assess soft tissue viability in older adults","volume":"78","author":"Jan","year":"2009","journal-title":"Microvasc Res"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0545","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1016\/j.neurobiolaging.2007.08.025","article-title":"A link between sICAM-1, ACE and parietal blood flow in the aging brain","volume":"30","author":"Janciauskiene","year":"2009","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0550","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1096\/fj.05-4232fje","article-title":"Elevated RhoA\/Rho-kinase activity in the aged rat penis: mechanism for age-associated erectile dysfunction","volume":"20","author":"Jin","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0555","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/ijir.2011.2","article-title":"eNOS-uncoupling in age-related erectile dysfunction","volume":"23","author":"Johnson","year":"2011","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0560","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/14653240902887267","article-title":"Nicotine-reduced endothelial progenitor cell senescence through augmentation of telomerase activity via the PI3K\/Akt pathway","volume":"11","author":"Junhui","year":"2009","journal-title":"Cytotherapy"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0565","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1073\/pnas.070046397","article-title":"Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization","volume":"97","author":"Kalka","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0570","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.exger.2004.04.001","article-title":"Basal cerebral blood flow is dependent on the nitric oxide pathway in elderly but not in young healthy men","volume":"39","author":"Kamper","year":"2004","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0575","first-page":"H1087","article-title":"Aging impairs flow-induced dilation in coronary arterioles: role of NO and H2O2","volume":"297","author":"Kang","year":"2009","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0580","doi-asserted-by":"crossref","first-page":"970","DOI":"10.5551\/jat.4333","article-title":"Resveratrol protects human endothelium from H2O2-induced oxidative stress and senescence via SirT1 activation","volume":"30","author":"Kao","year":"2010","journal-title":"J Atheroscler Thromb"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0585","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.neurobiolaging.2004.08.011","article-title":"Oxidative state in platelets and erythrocytes in aging and Alzheimer's disease","volume":"26","author":"Kawamoto","year":"2005","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0590","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1007\/s00395-008-0742-z","article-title":"Impaired endothelial progenitor cell function predicts age-dependent carotid intimal thickening","volume":"103","author":"Keymel","year":"2008","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0595","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3233\/JAD-2002-4603","article-title":"Mechanisms of peripheral microvascular dysfunction in transgenic mice overexpressing the Alzheimer's disease amyloid A\u03b2 protein","volume":"4","author":"Khalil","year":"2002","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0600","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1161\/01.CIR.0000060496.23144.A7","article-title":"Asymmetric dimethylarginine, blood pressure, and renal; perfusion in elderly subjects","volume":"107","author":"Kielstein","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0605","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/79510","article-title":"The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals","volume":"6","author":"Kureishi","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0610","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/36285","article-title":"Mutation of the mouse klotho gene leads to a syndrome resembling ageing","volume":"390","author":"Kuro-o","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0615","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1242\/jcs.01097","article-title":"Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells","volume":"117","author":"Kurz","year":"2004","journal-title":"J Cell Sci"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0620","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1515\/CCLM.2009.016","article-title":"Aging and endothelial progenitor cell telomere length in healthy men","volume":"47","author":"Kushner","year":"2009","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0625","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.exger.2008.04.002","article-title":"Alzheimer's disease, cerebrovascular dysfunction and the benefits of exercise: from vessels to neurons","volume":"43","author":"Lange-Assochenfeldt","year":"2008","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0630","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00395-008-0714-3","article-title":"Age-dependent endothelial dysfunction is associated with failure to increase plasma nitrite in response to exercise","volume":"103","author":"Lauer","year":"2008","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0635","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1161\/01.CIR.0000109141.48980.37","article-title":"Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis","volume":"109","author":"Laufs","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0640","first-page":"H2280","article-title":"Age impairs Flk-1 signaling and NO-mediated vasodilation in coronary arterioles","volume":"295","author":"LeBlanc","year":"2008","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0645","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1042\/BJ20090666","article-title":"The NADPH oxidase Nox4 restricts the replicative lifespan of human endothelial cells","volume":"423","author":"Lener","year":"2009","journal-title":"Biochem J"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0650","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/hipo.20085","article-title":"Hippocampal nitric oxide synthase and arginase and age-associated behavioral deficits","volume":"15","author":"Liu","year":"2005","journal-title":"Hippocampus"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0655","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1172\/JCI200113131","article-title":"HMG-CoA reductase inhibitor mobilizes bone marrow-derived endothelial progenitor cells","volume":"108","author":"Llevadot","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0660","first-page":"698","article-title":"Erectile dysfunction as a sentinel marker of endothelial dysfunction disease","volume":"50","author":"Lojanapiwat","year":"2009","journal-title":"Singapore Med J"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0665","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/S1357-2725(98)00071-5","article-title":"Role of nitric oxide in the control of apoptosis in the microvasculature","volume":"30","author":"L\u00f3pez-Farr\u00e9","year":"1998","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0670","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.eururo.2005.07.017","article-title":"Elevation of asymmetrical dimethylarginine (ADMA) and coronary artery disease in men with erectile dysfunction","volume":"48","author":"Maas","year":"2005","journal-title":"Eur Urol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0675","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s11065-009-9113-2","article-title":"Cerebral white matter integrity and cognitive aging: contributions from diffusion tensor imaging","volume":"19","author":"Madden","year":"2009","journal-title":"Neuropsychol Rev"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0680","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1291\/hypres.27.947","article-title":"Moderate regular exercise increases basal production of nitric oxide in elderly women","volume":"27","author":"Maeda","year":"2004","journal-title":"Hypertens Res"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0690","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1095\/biolreprod.102.007310","article-title":"Protein inhibitor of nitric oxide synthase (NOS) and the N-methyl-D-aspartate receptor are expressed in the rat and mouse penile nerves and colocalize with penile neuronal NOS","volume":"68","author":"Magee","year":"2003","journal-title":"Biol Reprod"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0685","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1093\/biolreprod\/67.1.20","article-title":"Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase","volume":"67","author":"Magee","year":"2002","journal-title":"Biol Reprod"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0695","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1743-6109.2007.00459.x","article-title":"Antisense and short hairpin RNA (shRNA) constructs targeting PIN (Protein Inhibitor of NOS) ameliorate aging-related erectile dysfunction in the rat","volume":"4","author":"Magee","year":"2007","journal-title":"J Sex Med"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0700","first-page":"H2188","article-title":"Improving insulin sensitivity via activation of PPAR-\u03b3 increases telomerase activity in the heart of OLETF rats","volume":"297","author":"Makino","year":"2009","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0705","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s10517-009-0315-7","article-title":"Role of nitric oxide in prevention of cognitive disorders in neurodegenerative brain injuries in rats","volume":"146","author":"Manukhina","year":"2008","journal-title":"Bull Exp Biol Med"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0710","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1442-2042.2007.01973.x","article-title":"Significance of nitric oxide and its modulation mechanisms by endogenous nitric oxide synthase inhibitors and arginase in the micturition disorders and erectile dysfunction","volume":"15","author":"Masuda","year":"2008","journal-title":"Int J Urol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0715","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1161\/hh2101.098443","article-title":"eNOS activity is reduced in senescent human endothelial cells: Preservation by hTERT immortalization","volume":"89","author":"Matsushita","year":"2001","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0720","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/10739680701641421","article-title":"Age-related alterations in reactivity of cerebral arterioles: role of oxidative stress","volume":"15","author":"Mayhan","year":"2008","journal-title":"Microcirculation"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0725","doi-asserted-by":"crossref","first-page":"15583","DOI":"10.1074\/jbc.272.25.15583","article-title":"Reciprocal regulation of endothelial nitric-oxide synthase by Ca2+-calmodulin and caveolin","volume":"272","author":"Michel","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0730","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1161\/01.CIR.0000013836.85741.17","article-title":"Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction","volume":"105","author":"Minamino","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0735","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1152\/japplphysiol.00229.2002","article-title":"Decreased nitric oxide- and axon reflex-mediated cutaneous vasodilation with age during local heating","volume":"93","author":"Minson","year":"2002","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0740","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/sj.emboj.7600045","article-title":"Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53\/p21-dependent pathway","volume":"23","author":"Miyauchi","year":"2004","journal-title":"EMBO J"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0745","first-page":"180","article-title":"Mental stress, heart rate, and endothelial function in patients with syndrome X","volume":"14","author":"Mizia","year":"2007","journal-title":"Cardiol J"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0750","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","article-title":"Nitric oxide: physiology, pathophysiology, and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0755","first-page":"H1662","article-title":"Aging impairs endothelium-dependent vasodilation in at skeletal muscle arterioles","volume":"283","author":"Muller-Delp","year":"2002","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0760","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1161\/01.CIR.0000027584.85865.B4","article-title":"Constitutive human telomerase reverse transcriptase expression enhances regenerative properties of endothelial progenitor cells","volume":"106","author":"Murasawa","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0765","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1177\/153537020623100205","article-title":"eNOS function and dysfunction in the penis","volume":"231","author":"Musicki","year":"2006","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0770","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1097\/01.ju.0000173006.47623.2c","article-title":"In vivo analysis of chronic phosphodiesterase-5 inhibition with sildenafil in penile erectile tissues: no tachyphylaxis effect","volume":"174","author":"Musicki","year":"2005","journal-title":"J Urol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0775","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1743-6109.2005.20349.x","article-title":"Age-related changes in phosphorylation of endothelial nitric oxide synthase in the rat penis","volume":"2","author":"Musicki","year":"2005","journal-title":"J Sex Med"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0780","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S1010-7940(03)00022-8","article-title":"Age-related changes in the protective effect of chronic administration of L-arginine on post-ischemic recovery of endothelial function","volume":"23","author":"Nakamura","year":"2003","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0785","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1017\/S1041610206004571","article-title":"Association between trait anxiety and endothelial function observed in elderly males but not in young males","volume":"19","author":"Narita","year":"2007","journal-title":"Int Psychogeriatr"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0790","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1080\/10253890802437779","article-title":"Proatherosclerotic effects of chronic stress in male rats: altered phenylephrine sensitivity and nitric oxide synthase activity of arota and circulating lipids","volume":"12","author":"Neves","year":"2009","journal-title":"Stress"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0795","doi-asserted-by":"crossref","first-page":"9287","DOI":"10.1523\/JNEUROSCI.3348-08.2008","article-title":"Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferators-activated receptor-\u03b3 agonist","volume":"28","author":"Nicolakakis","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0800","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1162\/jocn.2006.18.3.418","article-title":"White matter changes compromise prefrontal cortex function in healthy elderly individuals","volume":"18","author":"Nordahl","year":"2006","journal-title":"J Cogn Neurosci"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0805","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1111\/j.1464-410X.2007.06860.x","article-title":"Roles of attenuated neuronal nitric-oxide synthase protein expression and accelerated arginase activity in impairing neurogenic relaxation of corpus cavernosum in aged rabbits","volume":"99","author":"Numao","year":"2007","journal-title":"BJU Int"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0810","doi-asserted-by":"crossref","first-page":"5378","DOI":"10.1073\/pnas.0836098100","article-title":"Telomere attrition and Chk2 activation in human heart failure","volume":"100","author":"Oh","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0815","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000052786","article-title":"Diminished reserve for cerebral vasomotor response to L-arginine in the elderly: evaluation by transcranial Doppler sonography","volume":"47","author":"Okamoto","year":"2001","journal-title":"Gerontology"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0820","first-page":"H2651","article-title":"Mathematical modeling of vascular endothelial layer maintenance: the role of endothelial cell division, progenitor cell homing and telomere shortening","volume":"287","author":"Op den Buijs","year":"2004","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0825","doi-asserted-by":"crossref","first-page":"RC1","DOI":"10.1007\/BF03346251","article-title":"Platelet cGMP inversely correlates with age in healthy subjects","volume":"27","author":"Origlia","year":"2004","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0830","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.yjmcc.2007.08.008","article-title":"Sirt 1 modulates premature senescence-like phenotype in human endothelial cells","volume":"43","author":"Ota","year":"2007","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0835","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1161\/ATVBAHA.108.164368","article-title":"Cilostazol inhibits oxidative stress-induced premature senescence via upregualtion of Sirt 1 in human endothelial cells","volume":"28","author":"Ota","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0840","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1365-2605.2009.00993.x","article-title":"The effect of regular exercise on penile nitric oxide synthase expression in rats","volume":"33","author":"Ozbek","year":"2010","journal-title":"Int J Androl"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0850","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1038\/sj.jcbfm.9600491","article-title":"Nox2-derived reactive oxygen species mediate neurovascular dysregulation in the aging mouse brain","volume":"27","author":"Park","year":"2007","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0845","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jep.2004.04.028","article-title":"Elevation of intracevernous pressure and NO-cGMP activity by a new herbal formula in penile tissue of aged and diabetic rats","volume":"94","author":"Park","year":"2004","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0855","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0008-6363(00)00086-9","article-title":"Mechanisms of the pro- and anti-oxidant actions of nitric oxide in atherosclerosis","volume":"47","author":"Patel","year":"2000","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0860","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ijcard.2007.11.042","article-title":"Numbers of endothelial progenitor cells in peripheral blood are similar in younger and older patients with coronary artery disease","volume":"133","author":"Pelliccia","year":"2009","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0865","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1161\/HYPERTENSIONAHA.106.085035","article-title":"Paradoxical role of angiotensin II type 2 receptors in resistance arteries of old rats","volume":"50","author":"Pinaud","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0870","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.niox.2010.10.002","article-title":"Acute effect of a high nitrate diet on brain perfusion in older adults","volume":"24","author":"Presley","year":"2011","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0875","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1179\/016164104225014003","article-title":"Aging enhances vascular dysfunction induced by the Alzheimer's peptide \u03b1-amyloid","volume":"26","author":"Price","year":"2004","journal-title":"Neurol Res"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0880","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1359\/jbmr.070415","article-title":"Aging reduces skeletal blood flow, endothelium-dependent vasodilation, and NO bioavailability in rats","volume":"22","author":"Prisby","year":"2007","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0885","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.mehy.2007.05.025","article-title":"HDL slowing down endothelial progenitor cells senescence: a novel anti-atherogenic property of HDL","volume":"70","author":"Pu","year":"2008","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0890","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1111\/j.1743-6109.2008.00817.x","article-title":"Insulin-like growth factor-1 restores erectile function in aged rats. Modulation the integrity of smooth muscle and nitric oxide-cyclic guanosine monopohosphate signaling activity","volume":"5","author":"Pu","year":"2008","journal-title":"J Sex Med"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0895","doi-asserted-by":"crossref","first-page":"8075","DOI":"10.1523\/JNEUROSCI.0864-09.2009","article-title":"Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-\u03b2 load in an Alzheiner's disease mouse model","volume":"24","author":"Puzzo","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0900","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1097\/01.fjc.0000211736.55583.5c","article-title":"Age-dependent acceleration of ischemic injury in endothelial nitric oxide synthase-deficient mice: potential role of impaired VEGF receptor 2 expression","volume":"47","author":"Qian","year":"2006","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0905","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/j.1939-4640.2005.tb01084.x","article-title":"Rho-kinase inhibition improves erectile function in aging male Brown-Norway rats","volume":"26","author":"Rajasekaran","year":"2005","journal-title":"J Androl"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0910","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1001\/archneurol.2010.297","article-title":"Association of higher levels of high-density lipoprotein cholesterol in elderly individuals and lower risk of late-onset Alzheimer disease","volume":"67","author":"Reitz","year":"2010","journal-title":"Arch Neurol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0915","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1474-9726.2009.00466.x","article-title":"Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation","volume":"8","author":"Rodr\u00edguez-Ma\u0144as","year":"2009","journal-title":"Aging Cell"},{"issue":"Suppl. 1","key":"10.1016\/j.pharmthera.2011.10.004_bb0920","first-page":"89","article-title":"Erectile dysfunction in aging male","volume":"81","author":"Romanelli","year":"2010","journal-title":"Acta Biomed"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0925","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1093\/embo-reports\/kve174","article-title":"Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc\u2212\/\u2212 mice with short telomeres","volume":"2","author":"Samper","year":"2001","journal-title":"EMBO Rep"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0930","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1042\/CS20080404","article-title":"Effect of intensive lipid-lowering therapy on telomere erosion in endothelial progenitor cells obtained from patients with coronary artery disease","volume":"116","author":"Satoh","year":"2009","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0935","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1161\/01.ATV.0000141843.77133.fc","article-title":"Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl L-arginine accelerates endothelial cell senescence","volume":"24","author":"Scalera","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0940","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/j.jacc.2003.07.025","article-title":"Age-dependent depression in circulating endothelial progenitor cells in patients undergoing coronary artery bypass grafting","volume":"42","author":"Scheubel","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0945","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1113\/jphysiol.2006.124313","article-title":"Ageing reduces nitric oxide- and prostaglandin-mediated vasodilatation in exercising humans","volume":"579","author":"Schrage","year":"2007","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0950","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0197-4580(03)00007-1","article-title":"Increased concentrations of homocysteine and asymmetric dimethylarginine and decreased concentrations of nitric oxide in the plasma of patients with Alzheimer's disease","volume":"24","author":"Selley","year":"2003","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0955","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.amjmed.2006.06.010","article-title":"Prevalence and risk factors for erectile dysfunction in the US","volume":"120","author":"Selvin","year":"2007","journal-title":"Am J Med"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0960","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.jacc.2006.09.050","article-title":"Endothelial progenitor cellos in cardiovascular disorders","volume":"49","author":"Shantsila","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0965","first-page":"H2913","article-title":"Endothelial senescence after high-cholesterol, high-fat diet challenge in baboons","volume":"292","author":"Shi","year":"2007","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0970","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1161\/01.CIR.0000139854.74847.99","article-title":"Angiogenesis and vasculogenesis are impaired in the precocious-aging klotho mouse","volume":"110","author":"Shimada","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0975","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1474-9726.2011.00679.x","article-title":"Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging","volume":"10","author":"Sindler","year":"2011","journal-title":"Aging Cell"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0980","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0008-6363(02)00514-X","article-title":"Effects of a \u2018healthy\u2019 diet and of acute and long-term vitamin C on vascular function in healthy older subjects","volume":"56","author":"Singh","year":"2002","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0985","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1042\/CS20010262","article-title":"Ageing is associated with impairment of nitric oxide and prostanoids dilator pathways in the human forearm","volume":"102","author":"Singh","year":"2002","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0990","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1113\/jphysiol.2003.060301","article-title":"Effects of ageing and exercise training on endothelium-dependent vasodilatation and structure of rat skeletal muscle arterioles","volume":"556","author":"Spier","year":"2004","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb0995","first-page":"H3119","article-title":"Exercise training enhances flow-induced vasodilation in skeletal muscle resistance arteries of aged rats: role of PGI2 and nitric oxide","volume":"292","author":"Spier","year":"2007","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1000","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1161\/01.CIR.0000142866.50300.EB","article-title":"Stains enhance migratory capacity by upregulation of the telomere repeat-binding factor TRF2 in endothelial progenitor cells","volume":"110","author":"Spyridopoulos","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1005","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1161\/01.ATV.0000259299.38843.64","article-title":"Reconstituted high-density lipoprotein stimulates differentiation of endothelial progenitor cells and enhances ischemia-induced angiogenesis","volume":"27","author":"Sumi","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1010","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.jacc.2004.06.030","article-title":"Physical inactivity causes endothelial dysfunction in healthy young mice","volume":"44","author":"Suvorava","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1015","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1161\/01.CIR.101.25.2896","article-title":"Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes","volume":"101","author":"Taddei","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1020","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1161\/01.HYP.38.2.274","article-title":"Age-related reduction of NO availability and oxidative stress in humans","volume":"38","author":"Taddei","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1025","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1161\/01.CIR.91.7.1981","article-title":"Aging and endothelial function in normotensive subjects and patients with essential hypertension","volume":"91","author":"Taddei","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1030","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/jcbfm.2010.165","article-title":"Reduced ischemic brain injury by partial rejuvenation of bone marrow cells in aged rats","volume":"31","author":"Taguchi","year":"2011","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1035","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/jcb.21322","article-title":"Age-dependent telomere-shortening is repressed by phosphorylated \u03b1-tocopherol together with cellular longevity and intracellular oxidative-stress reduction in human brain microvascular endotheliocytes","volume":"102","author":"Tanaka","year":"2007","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1040","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/sj.jhh.1001996","article-title":"Circulating endothelial progenitor cell deficiency contributes to impaired arterial elasticity in persons of advancing age","volume":"20","author":"Tao","year":"2006","journal-title":"J Hum Hypertens"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1045","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/j.1474-9726.2006.00242.x","article-title":"Haematopoietic stem cells and endothelial progenitor cells in healthy men: effect of aging and raining","volume":"5","author":"Thijssen","year":"2006","journal-title":"Aging Cell"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1050","first-page":"85","article-title":"SU5416 induces premature senescence in endothelial progenitor cells from patients with age-related macular degeneration","volume":"17","author":"Thill","year":"2011","journal-title":"Mol Vis"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1055","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1161\/01.RES.0000257912.78915.af","article-title":"Age-dependent impairment of endothelial progenitor cells is correlated by growth-hormone-mediated increase of insulin-like growth-factor-1","volume":"100","author":"Thum","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1060","series-title":"Nitric oxide and the peripheral nervous system","first-page":"37","article-title":"Nitrergic (nitroxidergic) innervation in the blood vessel","author":"Toda","year":"2000"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1065","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/HJH.0b013e328341d19e","article-title":"Salt-induced hemodynamic regulation mediated by nitric oxide","volume":"29","author":"Toda","year":"2011","journal-title":"J Hypertens"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1070","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/alcalc\/agq028","article-title":"Vascular actions of nitric oxide as affected by exposure to alcohol","volume":"45","author":"Toda","year":"2010","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1075","first-page":"H103","article-title":"Neural mechanism underlying basilar arterial constriction by intracisternal L-NNA in anesthetized dogs","volume":"265","author":"Toda","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1080","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.pharmthera.2004.11.011","article-title":"Nitric oxide and penile erectile function","volume":"106","author":"Toda","year":"2005","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1085","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1139\/Y09-048","article-title":"Cerebral blood flow regulation by nitric oxide in neurological disorders","volume":"87","author":"Toda","year":"2009","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1090","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.pharmthera.2010.04.009","article-title":"Alteration of nitric oxide-mediated blood flow regulation in diabetes mellitus","volume":"127","author":"Toda","year":"2010","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1095","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/0006-291X(90)91275-W","article-title":"Possible role of nitric oxide in transmitting information from vasodilator nerve to cereboarterial muscle","volume":"170","author":"Toda","year":"1990","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1100","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1124\/pr.55.2.3","article-title":"The pharmacology of nitric oxide in the peripheral nervous system of blood vessels","volume":"55","author":"Toda","year":"2003","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2010.09.042","article-title":"Nitric oxide-mediated blood flow regulation as affected by smoking and nicotine","volume":"649","author":"Toda","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1110","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1111\/j.1464-410X.2011.10122.x","article-title":"Can simvastatin improve erectile function and health-related quality of life in men aged >40 years with erectile dysfunction? Rationale and design of the Erectile Dysfunction and Statins (EDS) Trial","volume":"108","author":"Trivedi","year":"2011","journal-title":"BJU Int"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1115","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1161\/01.ATV.0000216600.37436.cf","article-title":"High-density lipoproteins enhance progenitor-mediated endothelium repair in mice","volume":"26","author":"Tso","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1120","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1248\/bpb.32.341","article-title":"Cerebral cortical vasodilatation mediated by nicotinic cholinergic receptors: effects of old age and of chronic nicotine exposure","volume":"32","author":"Uchida","year":"2009","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1125","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0014-2999(96)00925-9","article-title":"Analysis of the vasodilator nerve function by nicotine in isolated dog skin artery","volume":"321","author":"Uchiyama","year":"1997","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1130","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/ajh.2008.278","article-title":"Aging and hypertension are independent risk factors for reduced number of circulating endothelial progenitor cells","volume":"21","author":"Umemura","year":"2008","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1135","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1161\/01.ATV.0000128897.54893.26","article-title":"Cardiovascular biology of the asymmetric dimethylarginine: dimethylarginine dimethylaminohydrolase pathway","volume":"24","author":"Vallance","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1140","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.mvr.2009.12.009","article-title":"Endothelial progenitor cells in vascular health: focus on lifestyle","volume":"79","author":"Van Craenenbroeck","year":"2010","journal-title":"Microvasc Res"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1145","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1161\/01.RES.87.7.540","article-title":"Nitric oxide activates telomerase and delays endothelial cell senescence","volume":"87","author":"Vasa","year":"2000","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1150","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1161\/hh1301.093953","article-title":"Number and migtratory activity of circulating endothelial progenital cells inversely correlate with risk factors for coronary artery disease","volume":"89","author":"Vasa","year":"2001","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1155","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1749-6632.2010.05786.x","article-title":"Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy","volume":"1207","author":"Vasilevko","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1160","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/sj.ijir.3901122","article-title":"Impairment of shear-stress-mediated vasodilation of cavernous arteries in erectile dysfunction","volume":"16","author":"Virag","year":"2004","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1165","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.mad.2008.01.004","article-title":"Chronic treatment with N-acetyl-cystein delays cellular senescence in endothelial cells isolated from a subgroups of atherosclerotic patients","volume":"129","author":"Voghel","year":"2008","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1170","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.mad.2007.09.006","article-title":"Cellular senescence in endothelial cells from atherosclerotic patients is accelerated by oxidative stress associated with cardiovascular risk factors","volume":"128","author":"Voghel","year":"2007","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1175","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.mad.2010.04.004","article-title":"Endogenous oxidative stress prevents telomerase-dependent immortalization of human endothelial cells","volume":"131","author":"Voghel","year":"2010","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1180","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1161\/HYPERTENSIONAHA.109.145870","article-title":"Vascular endothelial function is related to white blood cell count and myeloperoxidase among healthy middle-aged and older adults","volume":"55","author":"Walker","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1185","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1161\/CIRCULATIONAHA.108.790469","article-title":"Increased vascular senescence and impaired endothelial progenitor cell function mediated by mutation of circadian gene Per2","volume":"118","author":"Wang","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1190","first-page":"284","article-title":"Multiple peptides in cutaneous nerves: regulators under physiological conditions and a pathogenic role in skin disease?","volume":"7","author":"Weihe","year":"1988","journal-title":"Semin Dermatol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1195","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1161\/CIRCULATIONAHA.109.861005","article-title":"Physical exercise prevents cellular senescence in circulating leukocytes and in the vessel wall","volume":"120","author":"Werner","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1200","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jacc.2008.04.034","article-title":"Effects of physical exercise on myocardial telomere-regulating proteins, survival pathways, and apoptosis","volume":"52","author":"Werner","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1205","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1056\/NEJMoa043814","article-title":"Circulating endothelial progenitor cells and cardiovascular outcomes","volume":"353","author":"Werner","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1210","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1042\/CS20090253","article-title":"Relationship between circulating progenitor cells, vascular function and oxidative stress with long-term training and short-term detraining in older men","volume":"118","author":"Witkowski","year":"2010","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1215","first-page":"825","article-title":"Alzheimer's disease drug discovery\u2013\u201311th International Conference\u2013\u2013promising new therapeutic approaches","volume":"13","author":"Wolfe","year":"2010","journal-title":"IDrugs"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1220","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1152\/japplphysiol.01073.2002","article-title":"Selected contribution: aging impairs nitric oxide and prostacyclin mediation of endothelium-dependent dilation in soleus feed arteries","volume":"95","author":"Woodman","year":"2003","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1225","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1152\/japplphysiol.00408.2004","article-title":"Shear stress induces eNOS mRNA expression and improves endothelium-dependent dilation in senescent soleus muscle feed arteries","volume":"98","author":"Woodman","year":"2005","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1230","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1152\/japplphysiol.00416.2007","article-title":"Short-term increases in intraluminal pressure reverse age-related decrements in endothelium dependent dilation in soleus muscle feed arteries","volume":"103","author":"Woodman","year":"2007","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1240","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/j.bbagen.2006.04.007","article-title":"PIN inhibits nitric oxide and superoxide production from purified neuronal nitric oxide synthase","volume":"1760","author":"Xia","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1235","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/bjp.2008.272","article-title":"Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms","volume":"155","author":"Xia","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1245","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0014-5793(00)01278-3","article-title":"Homocysteine accelerates endothelial cell senescence","volume":"470","author":"Xu","year":"2000","journal-title":"FEBS Lett"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1250","first-page":"H3105","article-title":"Chronic high blood flow potentiates shear stress-induced release of NO in arteries of aged rats","volume":"293","author":"Yan","year":"2007","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1255","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.arr.2008.02.001","article-title":"Cyclin-dependent kinase inhibitor p16(INK4a) and telomerase may co-modulate endothelial progenitor cells senescence","volume":"7","author":"Yang","year":"2008","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1260","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000129064","article-title":"Advanced age is associated with endothelial dysfunction in healthy elderly subjects","volume":"54","author":"Yavuz","year":"2008","journal-title":"Gerontology"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1265","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.2337\/db05-1607","article-title":"Apoptosis signal-regulating kinase 1 mediates cellular senescence induced by high glucose in endothelial cells","volume":"55","author":"Yokoi","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1270","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1016\/j.transproceed.2003.08.032","article-title":"In vitro senescence occurring in normal human endothelial cells can be rescued by ectopic telomerase activity","volume":"35","author":"Young","year":"2003","journal-title":"Transplant Proc"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1275","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.vph.2007.08.002","article-title":"Role of cytochrome P450 metabolites of arachidonic acid in regulation of corporal smooth muscle tone in diabetic and older rats","volume":"47","author":"Yousif","year":"2007","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1280","doi-asserted-by":"crossref","first-page":"14790","DOI":"10.1074\/jbc.M414644200","article-title":"Telomerase mediates vascular endothelial growth factor-dependent responsiveness in a rat model of hind limb ischemia","volume":"280","author":"Zaccagnini","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1285","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.2741\/2954","article-title":"Atherosclerosis as a disease of failed endogenous repair","volume":"13","author":"Zenovich","year":"2008","journal-title":"Front Biosci"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1290","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1096\/fj.08-110296","article-title":"Premature senescence of highly proliferative endothelial progenitor cells is induced by tumor necrosis factor-\u03b1 via the p38 mitogen-activated protein kinase pathway","volume":"23","author":"Zhang","year":"2009","journal-title":"FASEB J"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1295","first-page":"H2227","article-title":"Abnormal nitric oxide production in aged rat mesenteric arteries is mediated by NAD(P)H oxidase-derived peroxide","volume":"297","author":"Zhou","year":"2009","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1300","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.atherosclerosis.2010.08.050","article-title":"Calcitonin gene-related peptide inhibits angiotensin II-induced endothelial progenitor cells senescence through up-regulation of klotho expression","volume":"213","author":"Zhou","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2011.10.004_bb1305","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.avsg.2008.11.013","article-title":"Young environment reverses the declined activity of aged rat-derived endothelial progenitor cells: involvement of the phosphatidylinositol 3-kinase\/Akt signaling pathway","volume":"23","author":"Zhu","year":"2009","journal-title":"Ann Vasc Surg"}],"container-title":["Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725811001999?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725811001999?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T14:11:15Z","timestamp":1741875075000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725811001999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":261,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0163725811001999"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2011.10.004","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}