{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:58:31Z","timestamp":1791215911880,"version":"4.1.0"},"reference-count":283,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.pharmthera.2012.06.006","type":"journal-article","created":{"date-parts":[[2012,6,29]],"date-time":"2012-06-29T09:03:26Z","timestamp":1340960606000},"page":"337-354","source":"Crossref","is-referenced-by-count":92,"title":["Regression of pathological cardiac hypertrophy: Signaling pathways and therapeutic targets"],"prefix":"10.1016","volume":"135","author":[{"given":"Jianglong","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. James","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharmthera.2012.06.006_bb0005","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/cvr\/cvr015","article-title":"Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophy","volume":"90","author":"Abel","year":"2011","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0010","doi-asserted-by":"crossref","first-page":"S220","DOI":"10.1016\/j.cardfail.2004.09.005","article-title":"Surgical therapies for heart failure","volume":"10","author":"Acker","year":"2004","journal-title":"J Card Fail"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0015","first-page":"199","article-title":"Letter: ischemic heart disease, water hardness and myocardial magnesium","volume":"113","author":"Anderson","year":"1975","journal-title":"Can Med Assoc J"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0020","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1161\/01.RES.58.1.26","article-title":"Myocardial infarction in rats. Infarct size, myocyte hypertrophy, and capillary growth","volume":"58","author":"Anversa","year":"1986","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0025","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1016\/j.jacc.2006.02.003","article-title":"Cardiac regeneration","volume":"47","author":"Anversa","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0030","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1073\/pnas.0813013106","article-title":"The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload","volume":"106","author":"Backs","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0035","doi-asserted-by":"crossref","first-page":"H122","DOI":"10.1152\/ajpheart.00233.2002","article-title":"Changes in extracellular collagen matrix alter myocardial systolic performance","volume":"284","author":"Baicu","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0040","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1172\/JCI116461","article-title":"Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium","volume":"91","author":"Balligand","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0045","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1161\/hc3101.093903","article-title":"Comparison of right and left ventricular responses to left ventricular assist device support in patients with severe heart failure: a primary role of mechanical unloading underlying reverse remodeling","volume":"104","author":"Barbone","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0050","doi-asserted-by":"crossref","first-page":"II216","DOI":"10.1161\/01.CIR.100.suppl_2.II-216","article-title":"Myocardial gene expression of regulators of myocyte apoptosis and myocyte calcium homeostasis during hemodynamic unloading by ventricular assist devices in patients with end-stage heart failure","volume":"100","author":"Bartling","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0055","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1056\/NEJMp078131","article-title":"Bridge to life\u2014cardiac mechanical support","volume":"357","author":"Baughman","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0060","first-page":"H2240","article-title":"Generation of superoxide in cardiomyocytes during ischemia before reperfusion","volume":"277","author":"Becker","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0065","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1161\/CIRCRESAHA.110.231233","article-title":"G protein coupled receptor kinases as therapeutic targets in cardiovascular disease","volume":"109","author":"Belmonte","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0070","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0092-8674(03)00687-1","article-title":"Adult cardiac stem cells are multipotent and support myocardial regeneration","volume":"114","author":"Beltrami","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0075","doi-asserted-by":"crossref","first-page":"H8","DOI":"10.1152\/ajpheart.01303.2004","article-title":"Does load-induced ventricular hypertrophy progress to systolic heart failure?","volume":"289","author":"Berenji","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0080","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1540-8191.2005.2004105.x","article-title":"Left ventricular unloading with an assist device results in receptor relocalization as well as increased beta-adrenergic receptor numbers: are these changes indications for outcome?","volume":"20","author":"Bick","year":"2005","journal-title":"J Card Surg"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0085","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.yjmcc.2007.01.006","article-title":"Can the cardiomyocyte cell cycle be reprogrammed?","volume":"42","author":"Bicknell","year":"2007","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0090","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1161\/CIRCULATIONAHA.109.933960","article-title":"Reversal of severe heart failure with a continuous-flow left ventricular assist device and pharmacological therapy: a prospective study","volume":"123","author":"Birks","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0095","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.1016\/S0021-9258(19)83652-9","article-title":"Reaction rates of creatine kinase and ATP synthesis in the isolated rat heart. A 31P NMR magnetization transfer study","volume":"260","author":"Bittl","year":"1985","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0100","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1161\/CIRCULATIONAHA.105.577601","article-title":"Outcomes of children bridged to heart transplantation with ventricular assist devices: a multi-institutional study","volume":"113","author":"Blume","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0105","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1524-475X.2010.00573.x","article-title":"Molecular mechanisms of enhanced wound healing by copper oxide-impregnated dressings","volume":"18","author":"Borkow","year":"2010","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0110","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.healun.2010.10.016","article-title":"Clinical outcomes for continuous-flow left ventricular assist device patients stratified by pre-operative INTERMACS classification","volume":"30","author":"Boyle","year":"2011","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0115","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.bbabio.2006.04.011","article-title":"Proapoptotic BCL-2 family members and mitochondrial dysfunction during ischemia\/reperfusion injury, a study employing cardiac HL-1 cells and GFP biosensors","volume":"1757","author":"Brady","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0120","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.1111\/j.1742-4658.2007.05849.x","article-title":"The autophagic response to nutrient deprivation in the hl-1 cardiac myocyte is modulated by Bcl-2 and sarco\/endoplasmic reticulum calcium stores","volume":"274","author":"Brady","year":"2007","journal-title":"FEBS J"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0125","first-page":"H176","article-title":"Nitric oxide attenuates cardiac myocyte contraction","volume":"265","author":"Brady","year":"1993","journal-title":"Am J Physiol"},{"issue":"Suppl. D","key":"10.1016\/j.pharmthera.2012.06.006_bb0130","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/eurheartj\/15.suppl_D.45","article-title":"Regulation of the structural remodelling of the myocardium: from hypertrophy to heart failure","volume":"15","author":"Brilla","year":"1994","journal-title":"Eur Heart J"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0135","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S1053-2498(00)00321-1","article-title":"Regression of fibrosis and hypertrophy in failing myocardium following mechanical circulatory support","volume":"20","author":"Bruckner","year":"2001","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0140","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.carpath.2008.02.004","article-title":"Cardiomyocyte death and renewal in the normal and diseased heart","volume":"17","author":"Buja","year":"2008","journal-title":"Cardiovasc Pathol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0145","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.cardiores.2006.10.002","article-title":"The role of TGF-beta signaling in myocardial infarction and cardiac remodeling","volume":"74","author":"Bujak","year":"2007","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0150","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1111\/j.1582-4934.2008.00620.x","article-title":"Crocetin protects against cardiac hypertrophy by blocking MEK\u2013ERK1\/2 signalling pathway","volume":"13","author":"Cai","year":"2009","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0155","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nm1582","article-title":"MicroRNA-133 controls cardiac hypertrophy","volume":"13","author":"Care","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0160","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.amjhyper.2004.11.035","article-title":"Extracellular matrix remodeling in the heart of the homocysteinemic obese rabbit","volume":"18","author":"Carroll","year":"2005","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0165","doi-asserted-by":"crossref","first-page":"8B","DOI":"10.1016\/j.amjcard.2005.03.003","article-title":"Neurohormonal activation in congestive heart failure and the role of vasopressin","volume":"95","author":"Chatterjee","year":"2005","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0170","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1038\/cdd.2009.49","article-title":"Superoxide is the major reactive oxygen species regulating autophagy","volume":"16","author":"Chen","year":"2009","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0175","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1242\/jcs.011163","article-title":"Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species","volume":"120","author":"Chen","year":"2007","journal-title":"J Cell Sci"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0180","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/j.1476-5381.1994.tb13155.x","article-title":"Lack of correlation of hypotensive effects with prevention of cardiac hypertrophy by perindopril after ligation of rat coronary artery","volume":"112","author":"Chiba","year":"1994","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0185","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/0002-8703(78)90503-3","article-title":"Differences in metal content of the heart muscle in death from ischemic heart disease","volume":"95","author":"Chipperfield","year":"1978","journal-title":"Am Heart J"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0190","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1095\/biolreprod59.6.1540","article-title":"A vascular endothelial growth factor antagonist is produced by the human placenta and released into the maternal circulation","volume":"59","author":"Clark","year":"1998","journal-title":"Biol Reprod"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0195","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S0008-6363(96)00104-6","article-title":"The role of matrix metalloproteinases in heart disease","volume":"32","author":"Cleutjens","year":"1996","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0200","doi-asserted-by":"crossref","first-page":"S344","DOI":"10.1054\/jcaf.2002.129261","article-title":"Integration of concepts: cardiac extracellular matrix remodeling after myocardial infarction","volume":"8","author":"Cleutjens","year":"2002","journal-title":"J Card Fail"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0205","doi-asserted-by":"crossref","first-page":"I37","DOI":"10.1161\/CIRCULATIONAHA.104.525352","article-title":"Long-term results in patients with idiopathic dilated cardiomyopathy after weaning from left ventricular assist devices","volume":"112","author":"Dandel","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0210","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ijcard.2004.08.023","article-title":"Mechanisms of neurohormonal activation in chronic congestive heart failure: pathophysiology and therapeutic implications","volume":"101","author":"Davila","year":"2005","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0215","first-page":"73","article-title":"The relationship between the copper and zinc intake with food and the prevalence of ischemic heart disease and its risk factors","author":"Davydenko","year":"1995","journal-title":"Lik Sprava"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0220","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1126\/science.1312256","article-title":"The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor","volume":"255","author":"de Vries","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0225","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1042\/bse0390105","article-title":"The final step in programmed cell death: phagocytes carry apoptotic cells to the grave","volume":"39","author":"deCathelineau","year":"2003","journal-title":"Essays Biochem"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0230","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/00001573-200111000-00003","article-title":"Clinical aspects of hypertensive myocardial fibrosis","volume":"16","author":"Diez","year":"2001","journal-title":"Curr Opin Cardiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0235","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1161\/01.CIR.97.23.2316","article-title":"Myocyte recovery after mechanical circulatory support in humans with end-stage heart failure","volume":"97","author":"Dipla","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0240","first-page":"1719","article-title":"Influence of environmental stress on pathogenesis of sudden cardiac death","volume":"36","author":"Eliot","year":"1977","journal-title":"Fed Proc"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0245","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1177\/153537020422900705","article-title":"Dietary copper restriction-induced changes in myocardial gene expression and the effect of copper repletion","volume":"229","author":"Elsherif","year":"2004","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0250","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1177\/15353702-0322807-06","article-title":"Congestive heart failure in copper-deficient mice","volume":"228","author":"Elsherif","year":"2003","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0255","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1093\/jn\/134.4.855","article-title":"Regression of dietary copper restriction-induced cardiomyopathy by copper repletion in mice","volume":"134","author":"Elsherif","year":"2004","journal-title":"J Nutr"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0260","doi-asserted-by":"crossref","first-page":"H2713","DOI":"10.1152\/ajpheart.2000.279.6.H2713","article-title":"Improved cardiac contractile functions in hypoxia-reoxygenation in rats treated with low concentration Co2+","volume":"279","author":"Endoh","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0265","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0039-6109(03)00213-5","article-title":"Short- and long-term mechanical ventricular assistance towards myocardial recovery","volume":"84","author":"Entwistle","year":"2004","journal-title":"Surg Clin North Am"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0270","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1124\/mol.108.051516","article-title":"Copper regulation of hypoxia-inducible factor-1 activity","volume":"75","author":"Feng","year":"2009","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0275","doi-asserted-by":"crossref","first-page":"11363","DOI":"10.1073\/pnas.162100799","article-title":"Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes","volume":"99","author":"Fiedler","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0280","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1161\/01.RES.68.5.1458","article-title":"Myocardial angiogenesis and coronary perfusion in left ventricular pressure-overload hypertrophy in the young lamb. Evidence for inhibition with chronic protamine administration","volume":"68","author":"Flanagan","year":"1991","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0285","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1161\/hc4401.099449","article-title":"Differential regulation of mitogen-activated protein kinases in the failing human heart in response to mechanical unloading","volume":"104","author":"Flesch","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0290","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1161\/01.CIR.89.6.2908","article-title":"First use of an untethered, vented electric left ventricular assist device for long-term support","volume":"89","author":"Frazier","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0295","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0003-4975(96)00437-7","article-title":"Improved left ventricular function after chronic left ventricular unloading","volume":"62","author":"Frazier","year":"1996","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0300","doi-asserted-by":"crossref","first-page":"H2702","DOI":"10.1152\/ajpheart.00836.2004","article-title":"Regression of pressure overload-induced left ventricular hypertrophy in mice","volume":"288","author":"Gao","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0305","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.cell.2005.08.032","article-title":"Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte","volume":"123","author":"Gardai","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0310","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.ajpath.2011.11.007","article-title":"The NF-kappaB subunit c-Rel stimulates cardiac hypertrophy and fibrosis","volume":"180","author":"Gaspar-Pereira","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0315","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1006\/jmcc.2002.2081","article-title":"Regulation of myocardial fibrillar collagen by angiotensin II. A role in hypertensive heart disease?","volume":"34","author":"Gonzalez","year":"2002","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0320","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1172\/JCI117504","article-title":"Reperfusion injury induces apoptosis in rabbit cardiomyocytes","volume":"94","author":"Gottlieb","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0325","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00395-009-0011-9","article-title":"Cardioprotection requires taking out the trash","volume":"104","author":"Gottlieb","year":"2009","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0330","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1046\/j.1471-4159.1999.0721981.x","article-title":"A nitric oxide\/cyclic GMP-dependent protein kinase pathway alters transmitter release and inhibition by somatostatin at a site downstream of calcium entry","volume":"72","author":"Gray","year":"1999","journal-title":"J Neurochem"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0335","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1161\/01.HYP.38.2.267","article-title":"Divergent biological actions of coronary endothelial nitric oxide during progression of cardiac hypertrophy","volume":"38","author":"Grieve","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0340","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1161\/CIRCRESAHA.108.187427","article-title":"Autophagy in ischemic heart disease","volume":"104","author":"Gustafsson","year":"2009","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0345","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1097\/01.mat.0000169125.21268.d7","article-title":"Left ventricular assist devices as bridge to heart transplantation in congestive heart failure with pulmonary hypertension","volume":"51","author":"Haddad","year":"2005","journal-title":"ASAIO J"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0350","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0008-6363(03)00533-9","article-title":"Mitochondrial permeability transition pore opening during myocardial reperfusion\u2014a target for cardioprotection","volume":"61","author":"Halestrap","year":"2004","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0355","doi-asserted-by":"crossref","first-page":"29776","DOI":"10.1074\/jbc.M603783200","article-title":"Enhancing macroautophagy protects against ischemia\/reperfusion injury in cardiac myocytes","volume":"281","author":"Hamacher-Brady","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0360","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1016\/S0735-1097(00)00594-5","article-title":"Attenuated coronary flow reserve and vascular remodeling in patients with hypertension and left ventricular hypertrophy","volume":"35","author":"Hamasaki","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0365","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1253\/circj.71.276","article-title":"Diacylglycerol kinase zeta attenuates pressure overload-induced cardiac hypertrophy","volume":"71","author":"Harada","year":"2007","journal-title":"Circ J"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0370","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1161\/hc3601.095718","article-title":"Electrophysiological alterations after mechanical circulatory support in patients with advanced cardiac failure","volume":"104","author":"Harding","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0375","doi-asserted-by":"crossref","DOI":"10.1007\/s12012-012-9174-y","article-title":"Ischemia-induced copper loss and suppression of angiogenesis in the pathogenesis of myocardial infarction","author":"He","year":"2012","journal-title":"Cardiovasc Toxicol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0380","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1161\/01.CIR.102.22.2713","article-title":"Chronic unloading by left ventricular assist device reverses contractile dysfunction and alters gene expression in end-stage heart failure","volume":"102","author":"Heerdt","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0385","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/nm.2181","article-title":"CIB1 is a regulator of pathological cardiac hypertrophy","volume":"16","author":"Heineke","year":"2010","journal-title":"Nat Med"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0390","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1053\/j.semtcvs.2004.09.008","article-title":"Pediatric cardiac transplantation","volume":"16","author":"Herrington","year":"2004","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0395","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1161\/ATVBAHA.111.240341","article-title":"The ATP-binding cassette transporter ABCG2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response","volume":"32","author":"Higashikuni","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0400","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1096\/fj.04-3399fje","article-title":"Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway","volume":"19","author":"Hirsila","year":"2005","journal-title":"FASEB J"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0405","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1124\/pr.56.4.3","article-title":"Vascular endothelial growth factor and angiogenesis","volume":"56","author":"Hoeben","year":"2004","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0410","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1172\/JCI17061","article-title":"Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A","volume":"111","author":"Holtwick","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0415","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1016\/S0003-4975(03)00460-0","article-title":"Bridge to recovery with the use of left ventricular assist device and clenbuterol","volume":"75","author":"Hon","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0420","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.molcel.2006.12.009","article-title":"Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2","volume":"25","author":"Hoyer-Hansen","year":"2007","journal-title":"Mol Cell"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0425","doi-asserted-by":"crossref","first-page":"7987","DOI":"10.1073\/pnas.95.14.7987","article-title":"Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin\u2013proteasome pathway","volume":"95","author":"Huang","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0430","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1096\/fj.04-1510fje","article-title":"Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart","volume":"18","author":"Huang","year":"2004","journal-title":"FASEB J"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0435","doi-asserted-by":"crossref","first-page":"H2141","DOI":"10.1152\/ajpheart.00829.2003","article-title":"Remodeling of the chronic severely failing ischemic sheep heart after coronary microembolization: functional, energetic, structural, and cellular responses","volume":"286","author":"Huang","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0440","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1152\/physrev.1992.72.2.369","article-title":"Angiogenesis in skeletal and cardiac muscle","volume":"72","author":"Hudlicka","year":"1992","journal-title":"Physiol Rev"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0445","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.athoracsur.2003.09.060","article-title":"Therapeutic angiogenesis in chronically ischemic porcine myocardium: comparative effects of bFGF and VEGF","volume":"77","author":"Hughes","year":"2004","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0450","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1161\/01.RES.0000257777.83431.13","article-title":"Capillary perfusion and wall shear stress are restored in the coronary circulation of hypertrophic right ventricle","volume":"100","author":"Huo","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0455","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1172\/JCI24405","article-title":"Mitochondrial energy metabolism in heart failure: a question of balance","volume":"115","author":"Huss","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0460","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1056\/NEJM198510243131704","article-title":"The creatine kinase system in normal and diseased human myocardium","volume":"313","author":"Ingwall","year":"1985","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0465","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1161\/01.RES.0000137170.41939.d9","article-title":"Is the failing heart energy starved? On using chemical energy to support cardiac function","volume":"95","author":"Ingwall","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0470","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/ng1494","article-title":"Dysregulation of the TSC\u2013mTOR pathway in human disease","volume":"37","author":"Inoki","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0475","first-page":"H2659","article-title":"Role of bradykinin\u2013NO pathway in prevention of cardiac hypertrophy by ACE inhibitor in rat cardiomyocytes","volume":"273","author":"Ishigai","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0480","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1126\/science.1059817","article-title":"HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing","volume":"292","author":"Ivan","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0485","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1161\/01.HYP.0000215207.54689.31","article-title":"Vascular endothelial growth factor blockade promotes the transition from compensatory cardiac hypertrophy to failure in response to pressure overload","volume":"47","author":"Izumiya","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0490","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1126\/science.1059796","article-title":"Targeting of HIF-alpha to the von Hippel\u2013Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation","volume":"292","author":"Jaakkola","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0495","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1161\/01.RES.0000126497.38281.23","article-title":"Cardiomyocyte-specific overexpression of nitric oxide synthase 3 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction","volume":"94","author":"Janssens","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0500","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1084\/jem.20061943","article-title":"Dietary copper supplementation reverses hypertrophic cardiomyopathy induced by chronic pressure overload in mice","volume":"204","author":"Jiang","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0505","first-page":"86","article-title":"Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats","volume":"74","author":"Kajstura","year":"1996","journal-title":"Lab Invest"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0510","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1161\/01.CIR.103.19.2387","article-title":"Novel molecular mechanism of increased myocardial endothelin-1 expression in the failing heart involving the transcriptional factor hypoxia-inducible factor-1alpha induced for impaired myocardial energy metabolism","volume":"103","author":"Kakinuma","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0515","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1527-5299.2005.03912.x","article-title":"Novel therapies for heart failure: vasopressin and selective aldosterone antagonists","volume":"11","author":"Kamath","year":"2005","journal-title":"Congest Heart Fail"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0520","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/labinvest.3780078","article-title":"Metallothionein inhibits myocardial apoptosis in copper-deficient mice: role of atrial natriuretic peptide","volume":"80","author":"Kang","year":"2000","journal-title":"Lab Invest"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0525","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.carpath.2005.03.003","article-title":"The spatial pattern of coronary capillaries in patients with dilated, ischemic, or inflammatory cardiomyopathy","volume":"14","author":"Karch","year":"2005","journal-title":"Cardiovasc Pathol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0530","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1161\/CIRCRESAHA.108.178459","article-title":"Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy","volume":"103","author":"Karpanen","year":"2008","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0535","first-page":"H366","article-title":"Coronary arterial tree remodeling in right ventricular hypertrophy","volume":"265","author":"Kassab","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0540","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1114\/1.280","article-title":"Remodeling of the bifurcation asymmetry of right coronary ventricular branches in hypertrophy","volume":"28","author":"Kassab","year":"2000","journal-title":"Ann Biomed Eng"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0545","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.cardiores.2005.02.012","article-title":"Sympathetic neuronal regulation of the heart in aging and heart failure","volume":"66","author":"Kaye","year":"2005","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0550","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3390\/ijerph2005010010","article-title":"Down-regulation of the expression of the FIH-1 and ARD-1 genes at the transcriptional level by nickel and cobalt in the human lung adenocarcinoma A549 cell line","volume":"2","author":"Ke","year":"2005","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0555","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1365-2567.2006.02336.x","article-title":"Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia","volume":"118","author":"Khan","year":"2006","journal-title":"Immunology"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0560","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0039-6109(03)00221-4","article-title":"Ventricular assistance to bridge to transplantation","volume":"84","author":"Kherani","year":"2004","journal-title":"Surg Clin North Am"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0565","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1161\/CIRCRESAHA.109.208314","article-title":"Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart","volume":"106","author":"Kinoshita","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0570","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/0003-4975(95)01087-4","article-title":"Influence of prolonged ventricular assistance on myocardial histopathology in intact heart","volume":"61","author":"Kinoshita","year":"1996","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0575","first-page":"197","article-title":"Ischemic heart disease as copper deficiency","volume":"258","author":"Klevay","year":"1989","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0580","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/15216540252774784","article-title":"VEGF receptor signaling and endothelial function","volume":"52","author":"Kliche","year":"2001","journal-title":"IUBMB Life"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0585","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1126\/science.290.5497.1717","article-title":"Autophagy as a regulated pathway of cellular degradation","volume":"290","author":"Klionsky","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0590","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.pbiomolbio.2008.02.002","article-title":"Impact of left ventricular assist device (LVAD) support on the cardiac reverse remodeling process","volume":"97","author":"Klotz","year":"2008","journal-title":"Prog Biophys Mol Biol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0595","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.yjmcc.2009.11.015","article-title":"Cyclic GMP\/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition","volume":"48","author":"Koitabashi","year":"2010","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0600","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1111\/j.1582-4934.2008.00319.x","article-title":"Sildenafil-mediated neovascularization and protection against myocardial ischaemia reperfusion injury in rats: role of VEGF\/angiopoietin-1","volume":"12","author":"Koneru","year":"2008","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0605","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1042\/bj20030107","article-title":"cGMP-dependent protein kinase protects cGMP from hydrolysis by phosphodiesterase-5","volume":"372","author":"Kotera","year":"2003","journal-title":"Biochem J"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0610","doi-asserted-by":"crossref","first-page":"12825","DOI":"10.1073\/pnas.202474099","article-title":"Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3","volume":"99","author":"Kubasiak","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0615","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.healun.2010.08.030","article-title":"Health-related quality of life and exercise tolerance in recipients of heart transplants and left ventricular assist devices: a prospective, comparative study","volume":"30","author":"Kugler","year":"2011","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0620","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.jtcvs.2010.08.010","article-title":"Acute impact of left ventricular unloading by left ventricular assist device on the right ventricle geometry and function: effect of nitric oxide inhalation","volume":"141","author":"Kukucka","year":"2011","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0625","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/nature03029","article-title":"The role of autophagy during the early neonatal starvation period","volume":"432","author":"Kuma","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0630","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/14017438109101028","article-title":"Mitochondrial injury and autophagocytosis within the myocardial cell after the cold ischaemic anoxic asystole","volume":"15","author":"Kyosola","year":"1981","journal-title":"Scand J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0635","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1056\/NEJM200003023420904","article-title":"Early expression of angiogenesis factors in acute myocardial ischemia and infarction","volume":"342","author":"Lee","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0640","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1084\/jem.185.8.1481","article-title":"Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis","volume":"185","author":"Leist","year":"1997","journal-title":"J Exp Med"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0645","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1152\/physrev.00013.2005","article-title":"Cardiac stem cells and mechanisms of myocardial regeneration","volume":"85","author":"Leri","year":"2005","journal-title":"Physiol Rev"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0650","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S1534-5807(04)00099-1","article-title":"Development by self-digestion: molecular mechanisms and biological functions of autophagy","volume":"6","author":"Levine","year":"2004","journal-title":"Dev Cell"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0655","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1161\/hc3501.095215","article-title":"Downregulation of matrix metalloproteinases and reduction in collagen damage in the failing human heart after support with left ventricular assist devices","volume":"104","author":"Li","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0660","first-page":"879","article-title":"Curcumin prevents and reverses murine cardiac hypertrophy","volume":"118","author":"Li","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0665","doi-asserted-by":"crossref","DOI":"10.1007\/s00421-011-2263-y","article-title":"Cardiac remodeling and function following exercise and angiotensin II receptor antagonism","author":"Libonati","year":"2011","journal-title":"Eur J Appl Physiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0670","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/00001573-199905000-00008","article-title":"Ventricular assistance for recovery of cardiac failure","volume":"14","author":"Loebe","year":"1999","journal-title":"Curr Opin Cardiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0675","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1161\/01.CIR.98.25.2800","article-title":"Gene therapy for myocardial angiogenesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia","volume":"98","author":"Losordo","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0680","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.yjmcc.2011.11.003","article-title":"STIM1-dependent store-operated Ca2+ entry is required for pathological cardiac hypertrophy","volume":"52","author":"Luo","year":"2012","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0685","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1067\/mtc.2001.112632","article-title":"Time course of reverse remodeling of the left ventricle during support with a left ventricular assist device","volume":"121","author":"Madigan","year":"2001","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0690","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/cvr\/cvp270","article-title":"VEGF receptor switching in heart development and disease","volume":"84","author":"Madonna","year":"2009","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0695","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1210\/en.2008-0634","article-title":"Thyroid hormone receptor-beta is associated with coronary angiogenesis during pathological cardiac hypertrophy","volume":"150","author":"Makino","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0700","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1161\/01.CIR.98.22.2383","article-title":"Low incidence of myocardial recovery after left ventricular assist device implantation in patients with chronic heart failure","volume":"98","author":"Mancini","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0705","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1182\/blood-2004-10-3980","article-title":"Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation","volume":"105","author":"Martin","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0710","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1054\/jcaf.2002.33167","article-title":"LVADs as long-term cardiac replacement: success but on what terms and at what cost?","volume":"8","author":"Massie","year":"2002","journal-title":"J Card Fail"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0715","doi-asserted-by":"crossref","first-page":"5197","DOI":"10.1093\/emboj\/20.18.5197","article-title":"Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation","volume":"20","author":"Masson","year":"2001","journal-title":"EMBO J"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0720","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4161\/cbt.3.1.547","article-title":"HIF-1: an oxygen and metal responsive transcription factor","volume":"3","author":"Maxwell","year":"2004","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0725","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/20459","article-title":"The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis","volume":"399","author":"Maxwell","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0730","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1161\/CIRCULATIONAHA.106.633180","article-title":"Cardiac improvement during mechanical circulatory support: a prospective multicenter study of the LVAD Working Group","volume":"115","author":"Maybaum","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0735","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/0003-4975(94)00953-8","article-title":"Structural and left ventricular histologic changes after implantable LVAD insertion","volume":"59","author":"McCarthy","year":"1995","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0740","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1016\/j.jacc.2010.01.031","article-title":"The prognostic value of N-terminal pro-B-type natriuretic peptide for death and cardiovascular events in healthy normal and stage A\/B heart failure subjects","volume":"55","author":"McKie","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0745","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrd2193","article-title":"Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface","volume":"6","author":"McKinsey","year":"2007","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0750","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1097\/01.crd.0000134861.15430.a6","article-title":"A history of orthotopic heart transplantation","volume":"13","author":"Meine","year":"2005","journal-title":"Cardiol Rev"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0755","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1136\/gut.2008.155028","article-title":"Vascular endothelial growth factor and angiopoietin-2 play a major role in the pathogenesis of vascular leakage in cirrhotic rats","volume":"58","author":"Melgar-Lesmes","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0760","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF03086131","article-title":"Cardiac remodelling: concentric versus eccentric hypertrophy in strength and endurance athletes","volume":"16","author":"Mihl","year":"2008","journal-title":"Neth Heart J"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0765","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/0092-8674(93)90573-9","article-title":"High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis","volume":"72","author":"Millauer","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0770","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.yjmcc.2009.10.026","article-title":"ER stress in cardiovascular disease","volume":"48","author":"Minamino","year":"2010","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0775","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1161\/CIRCULATIONAHA.107.737031","article-title":"Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy","volume":"117","author":"Moens","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0780","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1023\/B:MCBI.0000044385.55012.8f","article-title":"Current clinical perspectives on myocardial angiogenesis","volume":"264","author":"Mukherjee","year":"2004","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0785","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1161\/01.CIR.96.2.542","article-title":"Weaning from mechanical cardiac support in patients with idiopathic dilated cardiomyopathy","volume":"96","author":"Muller","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0790","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1172\/JCI1560","article-title":"Nitric oxide synthase modulates angiogenesis in response to tissue ischemia","volume":"101","author":"Murohara","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0795","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1172\/JCI200318611","article-title":"A matter of life and death: cardiac myocyte apoptosis and regeneration","volume":"111","author":"Nadal-Ginard","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0800","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jacc.2008.08.069","article-title":"Sildenafil stops progressive chamber, cellular, and molecular remodeling and improves calcium handling and function in hearts with pre-existing advanced hypertrophy caused by pressure overload","volume":"53","author":"Nagayama","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0805","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/nm1574","article-title":"The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress","volume":"13","author":"Nakai","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0810","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3949\/ccjm.70.3.223","article-title":"Mechanical treatment of heart failure: the growing role of LVADs and artificial hearts","volume":"70","author":"Nemeh","year":"2003","journal-title":"Cleve Clin J Med"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0815","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1161\/01.CIR.100.18.1847","article-title":"Downregulation of the Na+-creatine cotransporter in failing human myocardium and in experimental heart failure","volume":"100","author":"Neubauer","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0820","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1161\/CIRCRESAHA.108.174128","article-title":"Vascular endothelial growth factor receptor-1 regulates postnatal angiogenesis through inhibition of the excessive activation of Akt","volume":"103","author":"Nishi","year":"2008","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0825","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cardiores.2004.12.014","article-title":"Increased susceptibility to heart failure in response to volume overload in mice lacking natriuretic peptide receptor-A gene","volume":"66","author":"Nishikimi","year":"2005","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0830","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1161\/hc3301.094911","article-title":"Mechanical unloading restores beta-adrenergic responsiveness and reverses receptor downregulation in the failing human heart","volume":"104","author":"Ogletree-Hughes","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0835","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/35017054","article-title":"Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel\u2013Lindau protein","volume":"2","author":"Ohh","year":"2000","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0840","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1093\/ndt\/gfm715","article-title":"Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model","volume":"23","author":"Ohtomo","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0845","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1056\/NEJM199704173361603","article-title":"Apoptosis in the failing human heart","volume":"336","author":"Olivetti","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0850","doi-asserted-by":"crossref","first-page":"F1766","DOI":"10.1152\/ajprenal.00482.2007","article-title":"VASP: a TRPC4-associated phosphoprotein that mediates PKG-induced inhibition of store-operated calcium influx","volume":"293","author":"O'Neil","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0855","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ghir.2005.02.002","article-title":"IGF-I is a matter of heart","volume":"15","author":"Opgaard","year":"2005","journal-title":"Growth Horm IGF Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0860","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0140-6736(06)68074-4","article-title":"Controversies in ventricular remodelling","volume":"367","author":"Opie","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0865","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.yjmcc.2009.02.017","article-title":"Postconditioning inhibits mPTP opening independent of oxidative phosphorylation and membrane potential","volume":"46","author":"Paillard","year":"2009","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0870","first-page":"879","article-title":"Improvement in 2-year survival for ventricular assist device patients after implementation of an intensive surveillance protocol","volume":"30","author":"Pamboukian","year":"2011","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0875","doi-asserted-by":"crossref","first-page":"e22391","DOI":"10.1371\/journal.pone.0022391","article-title":"Comparative analysis of mRNA isoform expression in cardiac hypertrophy and development reveals multiple post-transcriptional regulatory modules","volume":"6","author":"Park","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0880","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1043-6618(03)00246-9","article-title":"Effect of nolomirole on monocrotaline-induced heart failure","volume":"49","author":"Pasini","year":"2004","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0885","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1038\/nm1095-1085","article-title":"Magnetic resonance mapping demonstrates benefits of VEGF-induced myocardial angiogenesis","volume":"1","author":"Pearlman","year":"1995","journal-title":"Nat Med"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0890","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF00926359","article-title":"Role of extracellular matrix proteins in heart function","volume":"129","author":"Pelouch","year":"1993","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0895","doi-asserted-by":"crossref","first-page":"H416","DOI":"10.1152\/ajpheart.00615.2004","article-title":"Effects of sodium nitroprusside in aortic stenosis associated with severe heart failure: pressure\u2013volume loop analysis using a numerical model","volume":"288","author":"Popovic","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0900","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.yjmcc.2007.07.061","article-title":"deltaPKC participates in the endoplasmic reticulum stress-induced response in cultured cardiac myocytes and ischemic heart","volume":"43","author":"Qi","year":"2007","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0905","doi-asserted-by":"crossref","DOI":"10.1124\/jpet.112.194662","article-title":"Copper is required for cobalt-induced transcriptional activity of hypoxia-inducible factor-1","author":"Qiu","year":"2012","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0910","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.healun.2007.05.012","article-title":"End-organ function in patients on long-term circulatory support with continuous- or pulsatile-flow assist devices","volume":"26","author":"Radovancevic","year":"2007","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0915","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1161\/01.RES.0000029232.42227.16","article-title":"Inducible expression of BNIP3 provokes mitochondrial defects and hypoxia-mediated cell death of ventricular myocytes","volume":"91","author":"Regula","year":"2002","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0920","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/S0002-9440(10)63711-X","article-title":"The vascular endothelial growth factor (VEGF) receptor Flt-1 (VEGFR-1) modulates Flk-1 (VEGFR-2) signaling during blood vessel formation","volume":"164","author":"Roberts","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0925","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1056\/NEJMoa012175","article-title":"Long-term use of a left ventricular assist device for end-stage heart failure","volume":"345","author":"Rose","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0930","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1161\/01.CIR.92.12.3568","article-title":"Effects of ACE inhibitors on circulating versus cardiac angiotensin II in volume overload-induced cardiac hypertrophy in rats","volume":"92","author":"Ruzicka","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0935","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1073\/pnas.0404984102","article-title":"Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice","volume":"102","author":"Sakurai","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0940","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S1010-7940(03)00179-9","article-title":"Left ventricular assist device as bridge to heart transplantation\u2014lessons learned with the MicroMed DeBakey axial blood flow pump","volume":"24","author":"Salzberg","year":"2003","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0945","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/nature05602","article-title":"p53-Induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload","volume":"446","author":"Sano","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0950","doi-asserted-by":"crossref","first-page":"H1697","DOI":"10.1152\/ajpheart.00595.2009","article-title":"Regulation of VASP phosphorylation in cardiac myocytes: differential regulation by cyclic nucleotides and modulation of protein expression in diabetic and hypertrophic heart","volume":"297","author":"Sartoretto","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0955","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.pbiomolbio.2004.01.005","article-title":"Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation","volume":"85","author":"Saucerman","year":"2004","journal-title":"Prog Biophys Mol Biol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0960","doi-asserted-by":"crossref","first-page":"19742","DOI":"10.1074\/jbc.M001932200","article-title":"Kinetic, thermodynamic, and developmental consequences of deleting creatine kinase isoenzymes from the heart. Reaction kinetics of the creatine kinase isoenzymes in the intact heart","volume":"275","author":"Saupe","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0965","doi-asserted-by":"crossref","first-page":"M271","DOI":"10.1097\/00002480-199207000-00035","article-title":"The effect of prolonged left ventricular support on myocardial histopathology in patients with end-stage cardiomyopathy","volume":"38","author":"Scheinin","year":"1992","journal-title":"ASAIO J"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0970","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4161\/auto.4214","article-title":"Oxidation as a post-translational modification that regulates autophagy","volume":"3","author":"Scherz-Shouval","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0975","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1038\/sj.emboj.7601623","article-title":"Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4","volume":"26","author":"Scherz-Shouval","year":"2007","journal-title":"EMBO J"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0980","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI0214190","article-title":"TGF-beta1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II","volume":"109","author":"Schultz Jel","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0985","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1017\/S1047951105000132","article-title":"Current issues and perspectives in hypoplasia of the left heart","volume":"15","author":"Sedmera","year":"2005","journal-title":"Cardiol Young"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0990","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1101\/gad.14.16.1983","article-title":"HIF-1 and human disease: one highly involved factor","volume":"14","author":"Semenza","year":"2000","journal-title":"Genes Dev"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb0995","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1023\/B:MCBI.0000041844.24424.35","article-title":"Changes in beta-adrenoceptors in heart failure due to myocardial infarction are attenuated by blockade of renin\u2013angiotensin system","volume":"263","author":"Sethi","year":"2004","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1000","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.jacc.2007.06.006","article-title":"Identification of protein disulfide isomerase as a cardiomyocyte survival factor in ischemic cardiomyopathy","volume":"50","author":"Severino","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1005","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1161\/CIRCGENETICS.108.806935","article-title":"Time-warped comparison of gene expression in adaptive and maladaptive cardiac hypertrophy","volume":"2","author":"Sheehy","year":"2009","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1010","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1536\/ihj.28.387","article-title":"Impaired coronary vasodilatory capacity after dipyridamole administration in hypertrophic cardiomyopathy","volume":"28","author":"Shimamatsu","year":"1987","journal-title":"Jpn Heart J"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1015","doi-asserted-by":"crossref","first-page":"H474","DOI":"10.1152\/ajpheart.00922.2006","article-title":"Contributory role of VEGF overexpression in endothelin-1-induced cardiomyocyte hypertrophy","volume":"293","author":"Shimojo","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1020","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1126\/science.1099993","article-title":"Autophagy in health and disease: a double-edged sword","volume":"306","author":"Shintani","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1025","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1172\/JCI24682","article-title":"Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure","volume":"115","author":"Shiojima","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1030","first-page":"115","article-title":"Glucose regulation: role of alpha and beta cells of pancreatic islets","volume":"31","author":"Shipp","year":"1961","journal-title":"J Med Assoc State Ala"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1035","first-page":"11","article-title":"The copper content of the myocardium in the acute form of ischemic heart disease","author":"Shliakhover","year":"1990","journal-title":"Vrach Delo"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1040","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s11373-005-3008-x","article-title":"Carvedilol prevents cardiac hypertrophy and overexpression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in pressure-overloaded rat heart","volume":"12","author":"Shyu","year":"2005","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1045","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.jtcvs.2009.12.006","article-title":"Bridge to transplant experience: factors influencing survival to and after cardiac transplant","volume":"139","author":"Smedira","year":"2010","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1050","first-page":"BR206","article-title":"Insulin treatment decreases the antioxidant defense mechanism in experimental diabetes","volume":"11","author":"Somogyi","year":"2005","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1055","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.bbrc.2007.01.095","article-title":"VEGF is critical for spontaneous differentiation of stem cells into cardiomyocytes","volume":"354","author":"Song","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1060","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/j.1745-7254.2008.00763.x","article-title":"Cellular mechanisms of reduced sarcoplasmic reticulum Ca2+ content in l-thyroxin induced rat ventricular hypertrophy","volume":"29","author":"Song","year":"2008","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1065","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0039-6109(05)70344-3","article-title":"Cardiac transplantation","volume":"78","author":"Spann","year":"1998","journal-title":"Surg Clin North Am"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1070","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1113\/expphysiol.2005.032607","article-title":"Correlation of alpha-skeletal actin expression, ventricular fibrosis and heart function with the degree of pressure overload cardiac hypertrophy in rats","volume":"91","author":"Stilli","year":"2006","journal-title":"Exp Physiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1075","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.jacc.2010.10.040","article-title":"Multicenter evaluation of an intrapericardial left ventricular assist system","volume":"57","author":"Strueber","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1080","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ijcard.2007.12.034","article-title":"Additive effect of AAV-mediated angiopoietin-1 and VEGF expression on the therapy of infarcted heart","volume":"133","author":"Su","year":"2009","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1085","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1161\/CIRCULATIONAHA.108.783852","article-title":"Long-term cardiac-targeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy","volume":"119","author":"Suckau","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1090","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1161\/CIRCULATIONAHA.106.643585","article-title":"Tumor necrosis factor-alpha mediates cardiac remodeling and ventricular dysfunction after pressure overload state","volume":"115","author":"Sun","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1095","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1161\/01.RES.0000162099.01268.d1","article-title":"Adenoviral gene transfer of FGF-5 to hibernating myocardium improves function and stimulates myocytes to hypertrophy and reenter the cell cycle","volume":"96","author":"Suzuki","year":"2005","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1100","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1248\/bpb.34.1785","article-title":"Vascular endothelial growth factor (VEGF), VEGF receptors and their inhibitors for antiangiogenic tumor therapy","volume":"34","author":"Takahashi","year":"2011","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1105","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nm1175","article-title":"Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy","volume":"11","author":"Takimoto","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1110","doi-asserted-by":"crossref","first-page":"427","DOI":"10.2174\/1566523023347643","article-title":"Gene therapy in cardiovascular diseases","volume":"2","author":"Tamirisa","year":"2002","journal-title":"Curr Gene Ther"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1115","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1038\/nm958","article-title":"Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure","volume":"9","author":"Tang","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1120","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.1093\/emboj\/19.16.4298","article-title":"Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel\u2013Lindau tumor suppressor protein","volume":"19","author":"Tanimoto","year":"2000","journal-title":"EMBO J"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1125","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.yjmcc.2004.12.002","article-title":"Akt3 overexpression in the heart results in progression from adaptive to maladaptive hypertrophy","volume":"38","author":"Taniyama","year":"2005","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1130","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.lfs.2011.08.004","article-title":"Nandrolone and resistance training induce heart remodeling: role of fetal genes and implications for cardiac pathophysiology","volume":"89","author":"Tanno","year":"2011","journal-title":"Life Sci"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1135","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1073\/pnas.1018925108","article-title":"Coexpression of VEGF and angiopoietin-1 promotes angiogenesis and cardiomyocyte proliferation reduces apoptosis in porcine myocardial infarction (MI) heart","volume":"108","author":"Tao","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1140","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/0006-291X(92)90483-2","article-title":"Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor","volume":"187","author":"Terman","year":"1992","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1145","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1161\/01.RES.0000233317.70421.03","article-title":"Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes","volume":"99","author":"Thuerauf","year":"2006","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1150","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1172\/JCI32024","article-title":"Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice","volume":"117","author":"Tirziu","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1155","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.bbamcr.2009.03.002","article-title":"Mitophagy","volume":"1793","author":"Tolkovsky","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1160","first-page":"H980","article-title":"Dipyridamole-induced capillary growth in normal and hypertrophic hearts","volume":"262","author":"Torry","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1165","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1161\/CIRCRESAHA.110.220764","article-title":"The transcription factor GATA-6 regulates pathological cardiac hypertrophy","volume":"107","author":"van Berlo","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1170","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.cardiores.2003.11.014","article-title":"Metabolic remodelling of the failing heart: the cardiac burn-out syndrome?","volume":"61","author":"van Bilsen","year":"2004","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1175","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.aquatox.2004.06.002","article-title":"Effects of short-term copper exposure on gill structure, metallothionein and hypoxia-inducible factor-1alpha (HIF-1alpha) levels in rainbow trout (Oncorhynchus mykiss)","volume":"69","author":"van Heerden","year":"2004","journal-title":"Aquat Toxicol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1180","doi-asserted-by":"crossref","first-page":"13027","DOI":"10.1073\/pnas.0805038105","article-title":"Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis","volume":"105","author":"van Rooij","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1185","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1006\/jmcc.1997.0497","article-title":"Significant levels of oxidants are generated by isolated cardiomyocytes during ischemia prior to reperfusion","volume":"29","author":"Vanden Hoek","year":"1997","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1190","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1378\/chest.129.6.1673","article-title":"Burying the dead: the impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung disease","volume":"129","author":"Vandivier","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1195","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.vph.2006.03.010","article-title":"Sildenafil induces angiogenic response in human coronary arteriolar endothelial cells through the expression of thioredoxin, hemeoxygenase and vascular endothelial growth factor","volume":"45","author":"Vidavalur","year":"2006","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1200","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/0735-1097(92)90360-Y","article-title":"Effect of progression of left ventricular hypertrophy on coronary artery dimensions in aortic valve disease","volume":"20","author":"Villari","year":"1992","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1205","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ijcard.2004.08.006","article-title":"Applying standard therapies to new targets: the use of ACE inhibitors and B-blockers for heart failure in adults with congenital heart disease","volume":"97","author":"Vonder Muhll","year":"2004","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1210","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/biof.5520080310","article-title":"Some new aspects of creatine kinase (CK): compartmentation, structure, function and regulation for cellular and mitochondrial bioenergetics and physiology","volume":"8","author":"Wallimann","year":"1998","journal-title":"Biofactors"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1215","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.vascn.2004.05.005","article-title":"Murine models for the study of congestive heart failure: Implications for understanding molecular mechanisms and for drug discovery","volume":"50","author":"Wang","year":"2004","journal-title":"J Pharmacol Toxicol Methods"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1220","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF03402040","article-title":"The molecular mechanism of autophagy","volume":"9","author":"Wang","year":"2003","journal-title":"Mol Med"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1225","doi-asserted-by":"crossref","first-page":"513","DOI":"10.7326\/0003-4819-152-8-201004200-00008","article-title":"Narrative review: harnessing molecular genetics for the diagnosis and management of hypertrophic cardiomyopathy","volume":"152","author":"Wang","year":"2010","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1230","first-page":"2488","article-title":"Monitoring tissue repair and fibrosis from a distance","volume":"96","author":"Weber","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1235","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1152\/physiol.00043.2010","article-title":"The athlete's heart vs. the failing heart: can signaling explain the two distinct outcomes?","volume":"26","author":"Weeks","year":"2011","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1240","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1161\/01.CIR.90.3.1410","article-title":"Angiotensin-converting enzyme inhibition prolongs survival and modifies the transition to heart failure in rats with pressure overload hypertrophy due to ascending aortic stenosis","volume":"90","author":"Weinberg","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1245","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nature03987","article-title":"Pathophysiological consequences of VEGF-induced vascular permeability","volume":"437","author":"Weis","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1250","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.suc.2003.12.010","article-title":"Ventricular assist devices as destination therapy","volume":"84","author":"Westaby","year":"2004","journal-title":"Surg Clin North Am"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1255","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.0954-6820.1965.tb04329.x","article-title":"Trace elements in human myocardial infarction determined by neutron activation analysis","volume":"178","author":"Wester","year":"1965","journal-title":"Acta Med Scand"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1260","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1172\/JCI112820","article-title":"Myocardial metabolism of free fatty acids. Studies with 14C-labeled substrates in humans","volume":"79","author":"Wisneski","year":"1987","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1265","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1093\/eurheartj\/ehi442","article-title":"The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure","volume":"26","author":"Witte","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1270","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.cardiores.2005.06.030","article-title":"Reverse remodeling following insertion of left ventricular assist devices (LVAD): a review of the morphological and molecular changes","volume":"68","author":"Wohlschlaeger","year":"2005","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1275","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1161\/hy1201.097292","article-title":"Gene transfer of cGMP-dependent protein kinase I enhances the antihypertrophic effects of nitric oxide in cardiomyocytes","volume":"39","author":"Wollert","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1280","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1098\/rstb.1994.0099","article-title":"Death from inside out: an overview","volume":"345","author":"Wyllie","year":"1994","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1285","doi-asserted-by":"crossref","first-page":"C1298","DOI":"10.1152\/ajpcell.00023.2011","article-title":"Transcriptional regulation of the Menkes copper ATPase (Atp7a) gene by hypoxia-inducible factor (HIF2{alpha}) in intestinal epithelial cells","volume":"300","author":"Xie","year":"2011","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1290","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.2174\/092986709787846622","article-title":"Role of copper in angiogenesis and its medicinal implications","volume":"16","author":"Xie","year":"2009","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1295","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/ncb1007-1102","article-title":"Autophagosome formation: core machinery and adaptations","volume":"9","author":"Xie","year":"2007","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1300","first-page":"83","article-title":"Dual inhibition of ACE and NEP provides greater cardioprotection in mice with heart failure","volume":"10","author":"Xu","year":"2004","journal-title":"J Card Fail"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1305","doi-asserted-by":"crossref","first-page":"13807","DOI":"10.1073\/pnas.0506843102","article-title":"Autophagy in chronically ischemic myocardium","volume":"102","author":"Yan","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1310","doi-asserted-by":"crossref","first-page":"6089","DOI":"10.1523\/JNEUROSCI.16-19-06089.1996","article-title":"Flk-1, a receptor for vascular endothelial growth factor (VEGF), is expressed by retinal progenitor cells","volume":"16","author":"Yang","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1315","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/cvr\/cvr283","article-title":"Enhanced cardiac PI3Kalpha signalling mitigates arrhythmogenic electrical remodelling in pathological hypertrophy and heart failure","volume":"93","author":"Yang","year":"2012","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1320","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1080\/10715760802112791","article-title":"Reactive oxygen species and nitric oxide regulate mitochondria-dependent apoptosis and autophagy in evodiamine-treated human cervix carcinoma HeLa cells","volume":"42","author":"Yang","year":"2008","journal-title":"Free Radic Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1325","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0008-6363(99)00349-1","article-title":"Apoptosis in relevant clinical situations: contribution of apoptosis in myocardial infarction","volume":"45","author":"Yaoita","year":"2000","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1330","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00395-009-0006-6","article-title":"Autophagy is required for preconditioning by the adenosine A1 receptor-selective agonist CCPA","volume":"104","author":"Yitzhaki","year":"2009","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1335","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.bbrc.2003.07.023","article-title":"Autophagy: a regulated bulk degradation process inside cells","volume":"313","author":"Yoshimori","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1340","doi-asserted-by":"crossref","first-page":"15911","DOI":"10.1074\/jbc.M300463200","article-title":"Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel\u2013Lindau protein by direct binding to hypoxia-inducible factor-alpha","volume":"278","author":"Yuan","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1345","doi-asserted-by":"crossref","first-page":"15077","DOI":"10.1073\/pnas.2436255100","article-title":"Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor","volume":"100","author":"Yue","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1350","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1161\/01.CIR.98.7.656","article-title":"Regression of cellular hypertrophy after left ventricular assist device support","volume":"98","author":"Zafeiridis","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1355","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/BF02795618","article-title":"Cardiac copper, magnesium, and zinc in recent and old myocardial infarction","volume":"10","author":"Zama","year":"1986","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1360","doi-asserted-by":"crossref","first-page":"26969","DOI":"10.1074\/jbc.M103213200","article-title":"Vascular permeability factor (VPF)\/vascular endothelial growth factor (VEGF) peceptor-1 down-modulates VPF\/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through phosphatidylinositol 3-kinase-dependent pathways","volume":"276","author":"Zeng","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1365","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1161\/CIRCRESAHA.110.231423","article-title":"Regulators of G-protein signaling in the heart and their potential as therapeutic targets","volume":"109","author":"Zhang","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1370","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0039-6109(03)00222-6","article-title":"Molecular biology of myocardial recovery","volume":"84","author":"Zhang","year":"2004","journal-title":"Surg Clin North Am"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1375","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/j.jacc.2010.08.612","article-title":"Myocardial remodeling is controlled by myocyte-targeted gene regulation of phosphodiesterase type 5","volume":"56","author":"Zhang","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1380","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1152\/physiolgenomics.00040.2004","article-title":"Microarray analysis of gene expression after transverse aortic constriction in mice","volume":"19","author":"Zhao","year":"2004","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1385","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1161\/CIRCULATIONAHA.110.955369","article-title":"Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction","volume":"122","author":"Zhong","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1390","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/cvr\/cvp178","article-title":"Copper-induced regression of cardiomyocyte hypertrophy is associated with enhanced vascular endothelial growth factor receptor-1 signalling pathway","volume":"84","author":"Zhou","year":"2009","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1395","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.yjmcc.2008.03.022","article-title":"Copper reverses cardiomyocyte hypertrophy through vascular endothelial growth factor-mediated reduction in the cell size","volume":"45","author":"Zhou","year":"2008","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1400","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.jnutbio.2008.06.007","article-title":"Regression of copper-deficient heart hypertrophy: reduction in the size of hypertrophic cardiomyocytes","volume":"20","author":"Zhou","year":"2009","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1405","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/sj.gt.3302416","article-title":"VEGF165 and angiopoietin-1 decreased myocardium infarct size through phosphatidylinositol-3 kinase and Bcl-2 pathways","volume":"12","author":"Zhou","year":"2005","journal-title":"Gene Ther"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1410","doi-asserted-by":"crossref","first-page":"R1503","DOI":"10.1152\/ajpregu.00227.2009","article-title":"Intramuscular VEGF repairs the failing heart: role of host-derived growth factors and mobilization of progenitor cells","volume":"297","author":"Zisa","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.pharmthera.2012.06.006_bb1415","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s12012-010-9080-0","article-title":"Cytochrome c oxidase is essential for copper-induced regression of cardiomyocyte hypertrophy","volume":"10","author":"Zuo","year":"2010","journal-title":"Cardiovasc Toxicol"}],"container-title":["Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725812001246?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725812001246?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T21:44:51Z","timestamp":1642628691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725812001246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":283,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0163725812001246"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2012.06.006","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}