{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:01:37Z","timestamp":1791093697367,"version":"4.1.0"},"reference-count":99,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.pharmthera.2012.08.006","type":"journal-article","created":{"date-parts":[[2012,8,18]],"date-time":"2012-08-18T02:31:04Z","timestamp":1345257064000},"page":"142-152","source":"Crossref","is-referenced-by-count":106,"title":["\u03b12-containing GABAA receptors: A target for the development of novel treatment strategies for CNS disorders"],"prefix":"10.1016","volume":"136","author":[{"given":"Elif","family":"Engin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Rudolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharmthera.2012.08.006_bb0005","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1007\/s10519-006-9069-4","article-title":"Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample","volume":"36","author":"Agrawal","year":"2006","journal-title":"Behav Genet"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0010","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1111\/j.1360-0443.2008.02236.x","article-title":"Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case\u2013control study","volume":"103","author":"Agrawal","year":"2008","journal-title":"Addiction"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0015","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/BF00178511","article-title":"Adinazolam, a new triazolobenzodiazepine, and imipramine in the treatment of major depressive disorder","volume":"88","author":"Amsterdam","year":"1986","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0020","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/7854_2009_30","article-title":"GABAA receptor alpha2\/alpha3 subtype-selective modulators as potential nonsedating anxiolytics","volume":"2","author":"Atack","year":"2010","journal-title":"Curr Top Behav Neurosci"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0025","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1124\/jpet.105.089920","article-title":"TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates","volume":"316","author":"Atack","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0030","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1111\/j.1530-0277.2007.00517.x","article-title":"Variation in GABRA2 predicts drinking behavior in project MATCH subjects","volume":"31","author":"Bauer","year":"2007","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0035","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nn.2447","article-title":"Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes","volume":"13","author":"Belforte","year":"2010","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0040","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/S0028-3908(96)00068-8","article-title":"GABAA receptor subtypes differentiated by their gamma-subunit variants: prevalence, pharmacology and subunit architecture","volume":"35","author":"Benke","year":"1996","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0045","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1124\/jpet.110.171645","article-title":"Loss of ethanol conditioned taste aversion and motor stimulation in knockin mice with ethanol-insensitive alpha2-containing GABA(A) receptors","volume":"336","author":"Blednov","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0050","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1124\/jpet.105.092452","article-title":"The delta subunit of gamma-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol","volume":"316","author":"Borghese","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0055","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.biopsych.2010.09.052","article-title":"A randomized clinical trial of MK-0777 for the treatment of cognitive impairments in people with schizophrenia","volume":"69","author":"Buchanan","year":"2011","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0060","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.biopsych.2004.09.029","article-title":"Amygdala responses to human faces in obsessive-compulsive disorder","volume":"56","author":"Cannistraro","year":"2004","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0065","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.biopsych.2010.01.001","article-title":"Reversal of ketamine-induced working memory impairments by the GABAAalpha2\/3 agonist TPA023","volume":"67","author":"Castner","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0070","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/sj.npp.1301456","article-title":"Markers in the 5\u2032-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene","volume":"33","author":"Covault","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0075","doi-asserted-by":"crossref","first-page":"8980","DOI":"10.1073\/pnas.142288699","article-title":"Trace fear conditioning involves hippocampal \u03b15 GABAA receptors","volume":"99","author":"Crestani","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0080","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/12207","article-title":"Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues","volume":"2","author":"Crestani","year":"1999","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0085","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/sj.bjp.0703717","article-title":"Mechanism of action of the hypnotic zolpidem in vivo","volume":"131","author":"Crestani","year":"2000","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0090","doi-asserted-by":"crossref","first-page":"5274","DOI":"10.1073\/pnas.85.14.5274","article-title":"Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats","volume":"85","author":"Di Chiara","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0095","doi-asserted-by":"crossref","first-page":"10682","DOI":"10.1523\/JNEUROSCI.1166-05.2005","article-title":"Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines","volume":"25","author":"Dias","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0100","doi-asserted-by":"crossref","first-page":"185","DOI":"10.15288\/jsa.2006.67.185","article-title":"Marital status, alcohol dependence, and GABRA2: evidence for gene\u2013environment correlation and interaction","volume":"67","author":"Dick","year":"2006","journal-title":"J Stud Alcohol"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0105","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s10519-005-9041-8","article-title":"The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages","volume":"36","author":"Dick","year":"2006","journal-title":"Behav Genet"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0110","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1001\/archgenpsychiatry.2009.48","article-title":"Role of GABRA2 in trajectories of externalizing behavior across development and evidence of moderation by parental monitoring","volume":"66","author":"Dick","year":"2009","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0115","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1073\/pnas.0910117107","article-title":"Cocaine effects on mouse incentive-learning and human addiction are linked to alpha2 subunit-containing GABAA receptors","volume":"107","author":"Dixon","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pbb.2008.01.015","article-title":"Targeted deletion of the GABRA2 gene encoding alpha2-subunits of GABA(A) receptors facilitates performance of a conditioned emotional response, and abolishes anxiolytic effects of benzodiazepines and barbiturates","volume":"90","author":"Dixon","year":"2008","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0125","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/ajmg.b.30349","article-title":"Linkage disequilibrium, haplotype and association studies of a chromosome 4 GABA receptor gene cluster: candidate gene variants for addictions","volume":"141B","author":"Drgon","year":"2006","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0130","doi-asserted-by":"crossref","first-page":"3845","DOI":"10.1523\/JNEUROSCI.3609-06.2007","article-title":"GABAergic control of adult hippocampal neurogenesis in relation to behavior indicative of trait anxiety and depression states","volume":"27","author":"Earnheart","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0135","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1086\/383283","article-title":"Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations","volume":"74","author":"Edenberg","year":"2004","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0140","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/npp.2008.171","article-title":"GABRG1 and GABRA2 as independent predictors for alcoholism in two populations","volume":"34","author":"Enoch","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0145","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.biopsych.2009.08.019","article-title":"The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence","volume":"67","author":"Enoch","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0150","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/ajmg.b.30336","article-title":"Dimensional anxiety mediates linkage of GABRA2 haplotypes with alcoholism","volume":"141B","author":"Enoch","year":"2006","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0155","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s10803-008-0646-7","article-title":"GABA(A) receptor downregulation in brains of subjects with autism","volume":"39","author":"Fatemi","year":"2009","journal-title":"J Autism Dev Disord"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0160","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.ijdevneu.2010.05.004","article-title":"Developmental co-regulation of the beta and gamma GABAA receptor subunits with distinct alpha subunits in the human dorsolateral prefrontal cortex","volume":"28","author":"Fillman","year":"2010","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0165","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/BF02801973","article-title":"Benzodiazepine-induced decreases in extracellular concentrations of dopamine in the nucleus accumbens after acute and repeated administration","volume":"106","author":"Finlay","year":"1992","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0170","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1097\/FBP.0b013e32830dc0c7","article-title":"Affective and cognitive effects of global deletion of alpha3-containing gamma-aminobutyric acid-A receptors","volume":"19","author":"Fiorelli","year":"2008","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0175","doi-asserted-by":"crossref","first-page":"7749","DOI":"10.1073\/pnas.92.17.7749","article-title":"Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptors","volume":"92","author":"Gunther","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0180","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0026-895X(25)13351-8","article-title":"Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors","volume":"44","author":"Hadingham","year":"1993","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0185","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1601-183X.2007.00369.x","article-title":"Human gamma-aminobutyric acid A receptor alpha2 gene moderates the acute effects of alcohol and brain mRNA expression","volume":"7","author":"Haughey","year":"2008","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0190","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.neurobiolaging.2010.12.006","article-title":"In vivo molecular imaging of the GABA\/benzodiazepine receptor complex in the aged rat brain","volume":"33","author":"Hoekzema","year":"2012","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0195","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0006-3223(03)00689-9","article-title":"Possible association between a haplotype of the GABA-A receptor alpha 1 subunit gene (GABRA1) and mood disorders","volume":"55","author":"Horiuchi","year":"2004","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0200","doi-asserted-by":"crossref","first-page":"12213","DOI":"10.1073\/pnas.2131679100","article-title":"Repeated neonatal handling with maternal separation permanently alters hippocampal GABAA receptors and behavioral stress responses","volume":"100","author":"Hsu","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0205","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0028-3908(91)90075-M","article-title":"Release of dopamine is reduced by diazepam more in the nucleus accumbens than in the caudate nucleus of conscious rats","volume":"30","author":"Invernizzi","year":"1991","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0210","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/da.20262","article-title":"Role of GABA in anxiety and depression","volume":"24","author":"Kalueff","year":"2007","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0215","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1111\/j.1530-0277.2010.01293.x","article-title":"A polymorphism in GABRA2 is associated with the medial frontal response to alcohol cues in an fMRI study","volume":"34","author":"Kareken","year":"2010","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0220","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1126\/science.1149381","article-title":"Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations","volume":"321","author":"Klausberger","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0225","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature06493","article-title":"Reversal of pathological pain through specific spinal GABAA receptor subtypes","volume":"451","author":"Knabl","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0230","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.pain.2008.10.015","article-title":"Genuine antihyperalgesia by systemic diazepam revealed by experiments in GABAA receptor point-mutated mice","volume":"141","author":"Knabl","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0235","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1073\/pnas.0306975101","article-title":"Modulation of rhythmic brain activity by diazepam: GABA(A) receptor subtype and state specificity","volume":"101","author":"Kopp","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0240","doi-asserted-by":"crossref","first-page":"649","DOI":"10.15288\/jsad.2008.69.649","article-title":"Multiple-domain predictors of problematic alcohol use in young adulthood","volume":"69","author":"Kramer","year":"2008","journal-title":"J Stud Alcohol Drugs"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0245","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1176\/appi.ajp.2008.08030395","article-title":"Subunit-selective modulation of GABA type A receptor neurotransmission and cognition in schizophrenia","volume":"165","author":"Lewis","year":"2008","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0250","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/nrn1648","article-title":"Cortical inhibitory neurons and schizophrenia","volume":"6","author":"Lewis","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0255","doi-asserted-by":"crossref","first-page":"10071","DOI":"10.1073\/pnas.1204606109","article-title":"Loss of functional GABA(A) receptors in the Alzheimer diseased brain","volume":"109","author":"Limon","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0260","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1111\/j.1530-0277.2008.00768.x","article-title":"The role of GABRA2 in alcohol dependence, smoking, and illicit drug use in an Australian population sample","volume":"32","author":"Lind","year":"2008","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0265","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.tins.2008.02.005","article-title":"Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia","volume":"31","author":"Lisman","year":"2008","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0270","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1126\/science.290.5489.131","article-title":"Molecular and neuronal substrate for the selective attenuation of anxiety","volume":"290","author":"Low","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0275","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.neuroscience.2011.04.010","article-title":"Neurosteroid and GABA-A receptor alterations in Alzheimer's disease, Parkinson's disease and multiple sclerosis","volume":"191","author":"Luchetti","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0280","doi-asserted-by":"crossref","first-page":"625","DOI":"10.15288\/jsad.2007.68.625","article-title":"The role of the GABRA2 polymorphism in multiplex alcohol dependence families with minimal comorbidity: within-family association and linkage analyses","volume":"68","author":"Matthews","year":"2007","journal-title":"J Stud Alcohol Drugs"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0285","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/75761","article-title":"Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor \u03b11 subtype","volume":"3","author":"McKernan","year":"2000","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0290","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.neuropharm.2010.10.020","article-title":"The rise of a new GABA pharmacology","volume":"60","author":"Mohler","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0295","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neuropharm.2011.08.040","article-title":"The GABA system in anxiety and depression and its therapeutic potential","volume":"62","author":"Mohler","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0300","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1124\/jpet.300.1.2","article-title":"A new benzodiazepine pharmacology","volume":"300","author":"Mohler","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0305","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.pbb.2008.02.010","article-title":"Alpha2-containing GABA(A) receptors are involved in mediating stimulant effects of cocaine","volume":"90","author":"Morris","year":"2008","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0310","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neuropharm.2011.03.017","article-title":"A question of balance\u2014positive versus negative allosteric modulation of GABAA recetpor subtypes as a driver of analgesic efficacy in rat models of inflammatory and neuropathic pain","volume":"61","author":"Munro","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0315","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1124\/jpet.108.144568","volume":"327","author":"Munro","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0320","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/mp.2008.81","article-title":"Association of childhood trauma exposure and GABRA2 polymorphisms with risk of posttraumatic stress disorder in adults","volume":"14","author":"Nelson","year":"2009","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0325","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.alcohol.2007.04.006","article-title":"GABAA receptor subtypes: the \u201cone glass of wine\u201d receptors","volume":"41","author":"Olsen","year":"2007","journal-title":"Alcohol"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0330","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1124\/pr.108.00505","article-title":"International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update","volume":"60","author":"Olsen","year":"2008","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0335","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1159\/000119363","article-title":"Positive association between the GABRA5 gene and unipolar recurrent major depression","volume":"36","author":"Oruc","year":"1997","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0340","doi-asserted-by":"crossref","first-page":"4959","DOI":"10.1113\/jphysiol.2011.216028","article-title":"Distinct mechanisms regulate GABAA receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells","volume":"589","author":"Panzanelli","year":"2011","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0345","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.jpsychores.2004.02.001","article-title":"Sleep and quantitative EEG in neurodegenerative disorders","volume":"56","author":"Petit","year":"2004","journal-title":"J Psychosom Res"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0350","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/sj.mp.4001739","article-title":"Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia","volume":"10","author":"Petryshen","year":"2005","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0355","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/0006-3223(95)00049-7","article-title":"Benzodiazepines as antidepressants: does GABA play a role in depression?","volume":"38","author":"Petty","year":"1995","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0360","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1002\/da.20628","article-title":"Association study between GABA receptor genes and anxiety spectrum disorders","volume":"26","author":"Pham","year":"2009","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0365","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/sj.npp.1300688","article-title":"GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride","volume":"30","author":"Pierucci-Lagha","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0370","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1038\/npp.2012.115","article-title":"Differential roles of GABA(A) receptor subtypes in benzodiazepine-induced enhancement of brain stimulation reward","volume":"37","author":"Reynolds","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0375","first-page":"613","article-title":"Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease","volume":"117","author":"Rissman","year":"2011","journal-title":"J Neurochem"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0380","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nrn1496","article-title":"Molecular and neuronal substrates for general anaesthetics","volume":"5","author":"Rudolph","year":"2004","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0385","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/44579","article-title":"Benzodiazepine actions mediated by specific \u03b3-aminobutyric acidA receptor subtypes","volume":"401","author":"Rudolph","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0390","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nrd3502","article-title":"Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes","volume":"10","author":"Rudolph","year":"2011","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0395","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.coph.2005.10.003","article-title":"GABA-based therapeutic approaches: GABAA receptor subtype functions","volume":"6","author":"Rudolph","year":"2006","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0400","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1001\/archpsyc.61.7.705","article-title":"Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression","volume":"61","author":"Sanacora","year":"2004","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0405","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1176\/appi.ajp.159.4.663","article-title":"Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitors","volume":"159","author":"Sanacora","year":"2002","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0410","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.biopsych.2010.04.024","article-title":"gamma-Aminobutyric acid-type A receptor deficits cause hypothalamic\u2013pituitary\u2013adrenal axis hyperactivity and antidepressant drug sensitivity reminiscent of melancholic forms of depression","volume":"68","author":"Shen","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0415","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2174\/156802611794863562","article-title":"A closer look at the high affinity benzodiazepine binding site on GABAA receptors","volume":"11","author":"Sigel","year":"2011","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0420","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.neuropharm.2012.03.001","article-title":"Benzodiazepine-induced anxiolysis and reduction of conditioned fear are mediated by distinct GABA(A) receptor subtypes in mice","volume":"63","author":"Smith","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0425","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neuropharm.2011.07.026","article-title":"Anxiety and depression: mouse genetics and pharmacological approaches to the role of GABA(A) receptor subtypes","volume":"62","author":"Smith","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0430","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jpsychires.2006.11.006","article-title":"GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence","volume":"42","author":"Soyka","year":"2008","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0435","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.2174\/138920112800784925","article-title":"Altered cortical GABA neurotransmission in schizophrenia: insights into novel theapeutic strategies","volume":"13","author":"Stan","year":"2012","journal-title":"Curr Pharm Biotechnol"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0440","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jpsychires.2009.08.013","article-title":"Wake and sleep EEG provide biomarkers in depression","volume":"44","author":"Steiger","year":"2010","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0445","first-page":"179S","article-title":"Increased amygdala activation to angry and contemptuous faces in generalized social phobia","volume":"59","author":"Stein","year":"2002","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0450","first-page":"179S-179S","article-title":"GABRA2 genetic variation and the response of the human amygdala and insula to fearful faces","volume":"59","author":"Stein","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0455","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1176\/appi.ajp.164.2.318","article-title":"Increased amygdala and insula activation during emotion processing in anxiety-prone subjects","volume":"164","author":"Stein","year":"2007","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0460","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.bbr.2009.08.025","article-title":"Diazepam and cocaine potentiate brain stimulation reward in C57BL\/6J mice","volume":"206","author":"Straub","year":"2010","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0465","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nature08758","article-title":"Neural bases for addictive properties of benzodiazepines","volume":"463","author":"Tan","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0470","doi-asserted-by":"crossref","first-page":"6464","DOI":"10.1073\/pnas.111055398","article-title":"Diazepam-induced changes in sleep: role of the alpha 1 GABA(A) receptor subtype","volume":"98","author":"Tobler","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0475","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.pharmtox.42.082701.160735","article-title":"Glutamatergic mechanisms in schizophrenia","volume":"42","author":"Tsai","year":"2002","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0480","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/mp.2011.33","article-title":"Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism","volume":"17","author":"Villafuerte","year":"2012","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0485","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bbr.2010.10.009","article-title":"Antidepressant-like properties of alpha2-containing GABA(A) receptors","volume":"217","author":"Vollenweider","year":"2011","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0490","doi-asserted-by":"crossref","first-page":"15218","DOI":"10.1073\/pnas.2435171100","article-title":"Ethanol enhances alpha 4 beta 3 delta and alpha 6 beta 3 delta gamma-aminobutyric acid type A receptors at low concentrations known to affect humans","volume":"100","author":"Wallner","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2012.08.006_bb0495","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1124\/jpet.106.106260","article-title":"Effects of ethanol on tonic GABA currents in cerebellar granule cells and mammalian cells recombinantly expressing GABA(A) receptors","volume":"319","author":"Yamashita","year":"2006","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725812001672?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725812001672?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T23:28:46Z","timestamp":1743982126000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725812001672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":99,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0163725812001672"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2012.08.006","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}