{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:50:40Z","timestamp":1777402240500,"version":"3.51.4"},"reference-count":144,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.pharmthera.2014.11.007","type":"journal-article","created":{"date-parts":[[2014,11,16]],"date-time":"2014-11-16T22:36:01Z","timestamp":1416177361000},"page":"111-122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Putative targeting of matrix metalloproteinase-8 in atherosclerosis"],"prefix":"10.1016","volume":"147","author":[{"given":"Shu","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharmthera.2014.11.007_bb0505","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.jvs.2010.01.057","article-title":"The pathophysiology of abdominal aortic aneurysm growth: corresponding and discordant inflammatory and proteolytic processes in abdominal aortic and popliteal artery aneurysms","volume":"51","author":"Abdul-Hussien","year":"2010","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0510","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1161\/01.ATV.11.5.1223","article-title":"Cytokines and growth factors positively and negatively regulate interstitial collagen gene expression in human vascular smooth muscle cells","volume":"11","author":"Amento","year":"1991","journal-title":"Arterioscler. Thromb."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0515","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1161\/01.CIR.82.3.973","article-title":"Elastase-induced experimental aneurysms in rats","volume":"82","author":"Anidjar","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0520","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0140-6736(04)16850-5","article-title":"A hierarchical Bayesian meta-analysis of randomised clinical trials of drug-eluting stents","volume":"364","author":"Babapulle","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0525","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1056\/NEJM198401193100307","article-title":"Hypothesis: vasa vasorum and neovascularization of human coronary arteries. A possible role in the pathophysiology of atherosclerosis","volume":"310","author":"Barger","year":"1984","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0530","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1161\/01.RES.78.1.38","article-title":"Inhibition of matrix metalloproteinase activity inhibits smooth muscle cell migration but not neointimal thickening after arterial injury","volume":"78","author":"Bendeck","year":"1996","journal-title":"Circ. Res."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0535","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.ejvs.2004.06.020","article-title":"The relationship between plasma MMP-1, -7, -8 and -13 levels and embolic potential during carotid endoluminal intervention","volume":"28","author":"Bicknell","year":"2004","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0540","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0741-5214(99)70354-X","article-title":"The matrix metalloproteinase inhibitor BB-94 limits expansion of experimental abdominal aortic aneurysms","volume":"29","author":"Bigatel","year":"1999","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0545","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1177\/10454411930040020401","article-title":"Matrix metalloproteinases: a review","volume":"4","author":"Birkedal-Hansen","year":"1993","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0550","first-page":"2037","article-title":"The collagen matrix of the heart","volume":"40","author":"Borg","year":"1981","journal-title":"Fed. Proc."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0555","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1161\/01.CIR.103.7.934","article-title":"Healed plaque ruptures and sudden coronary death: evidence that subclinical rupture has a role in plaque progression","volume":"103","author":"Burke","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0560","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1161\/01.CIR.98.20.2195","article-title":"Adenovirus-mediated gene transfer of the human tissue inhibitor of metalloproteinase-2 blocks vascular smooth muscle cell invasiveness in vitro and modulates neointimal development in vivo","volume":"98","author":"Cheng","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0565","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1161\/hq0102.101129","article-title":"Metalloproteinase inhibition and the response to angioplasty and stenting in atherosclerotic primates","volume":"22","author":"Cherr","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0570","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.atherosclerosis.2013.05.022","article-title":"Role of the angiotensin converting enzyme 1\/angiotensin II\/angiotensin receptor 1 axis in interstitial collagenase expression in human carotid atheroma","volume":"229","author":"Clancy","year":"2013","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0575","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/S0022-2828(05)82390-9","article-title":"Regulation of collagen degradation in the rat myocardium after infarction","volume":"27","author":"Cleutjens","year":"1995","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0580","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0735-1097(99)00630-0","article-title":"Cardiac remodeling\u2014concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling","volume":"35","author":"Cohn","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0585","doi-asserted-by":"crossref","first-page":"H1726","DOI":"10.1152\/ajpheart.00783.2011","article-title":"Testosterone and interleukin-1beta increase cardiac remodeling during coxsackievirus B3 myocarditis via serpin A 3n","volume":"302","author":"Coronado","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0590","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1172\/JCI2182","article-title":"Expression and localization of macrophage elastase (matrix metalloproteinase-12) in abdominal aortic aneurysms","volume":"102","author":"Curci","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0595","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1161\/ATVBAHA.114.303353","article-title":"Recent highlights of ATVB: aneurysms","volume":"34","author":"Daugherty","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0600","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1161\/01.CIR.94.8.2013","article-title":"Stability and instability: two faces of coronary atherosclerosis. The Paul Dudley White Lecture 1995","volume":"94","author":"Davies","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0605","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1136\/hrt.69.5.377","article-title":"Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage, and smooth muscle cell content","volume":"69","author":"Davies","year":"1993","journal-title":"Br. Heart J."},{"issue":"Suppl. 1","key":"10.1016\/j.pharmthera.2014.11.007_bb0610","first-page":"33","article-title":"Lipid and cellular constituents of unstable human aortic plaques","volume":"89","author":"Davies","year":"1994","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0615","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1161\/01.ATV.18.10.1625","article-title":"Matrix metalloproteinase-2 production and its binding to the matrix are increased in abdominal aortic aneurysms","volume":"18","author":"Davis","year":"1998","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0620","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1161\/01.CIR.101.25.2962","article-title":"Metalloproteinase inhibition reduces constrictive arterial remodeling after balloon angioplasty: a study in the atherosclerotic Yucatan micropig","volume":"101","author":"de Smet","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0625","doi-asserted-by":"crossref","first-page":"10214","DOI":"10.1158\/0008-5472.CAN-07-1683","article-title":"Association of matrix metalloproteinase-8 gene variation with breast cancer prognosis","volume":"67","author":"Decock","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0630","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/ng.2480","article-title":"Large-scale association analysis identifies new risk loci for coronary artery disease","volume":"45","author":"Deloukas","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0635","doi-asserted-by":"crossref","first-page":"35900","DOI":"10.1074\/jbc.M110.139634","article-title":"Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation","volume":"285","author":"Devel","year":"2010","journal-title":"J. Biol.Chem."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0640","doi-asserted-by":"crossref","first-page":"11152","DOI":"10.1074\/jbc.M600222200","article-title":"Development of selective inhibitors and substrate of matrix metalloproteinase-12","volume":"281","author":"Devel","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0650","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.atherosclerosis.2011.08.025","article-title":"Association of MMP-8 promoter gene polymorphisms with carotid atherosclerosis: preliminary study","volume":"219","author":"Djuric","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0655","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/jcla.20393","article-title":"Plasma levels of matrix metalloproteinase-8 in patients with carotid atherosclerosis","volume":"24","author":"Djuric","year":"2010","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0660","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1001\/archsurg.1984.01390160041009","article-title":"Elastolytic and collagenolytic studies of arteries. Implications for the mechanical properties of aneurysms","volume":"119","author":"Dobrin","year":"1984","journal-title":"Arch. Surg."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0665","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1161\/01.CIR.99.24.3199","article-title":"Expression of tissue inhibitor of matrix metalloproteinases 1 by use of an adenoviral vector inhibits smooth muscle cell migration and reduces neointimal hyperplasia in the rat model of vascular balloon injury","volume":"99","author":"Dollery","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0670","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1747-0285.2011.01148.x","article-title":"Pyrone-based inhibitors of metalloproteinase types 2 and 3 may work as conformation-selective inhibitors","volume":"78","author":"Durrant","year":"2011","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0675","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrc745","article-title":"New functions for the matrix metalloproteinases in cancer progression","volume":"2","author":"Egeblad","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0680","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1161\/CIRCULATIONAHA.104.517391","article-title":"Neutrophil depletion inhibits experimental abdominal aortic aneurysm formation","volume":"112","author":"Eliason","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0685","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1093\/cvr\/cvt060","article-title":"An important role of matrix metalloproteinase-8 in angiogenesis in vitro and in vivo","volume":"99","author":"Fang","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0690","doi-asserted-by":"crossref","first-page":"e71280","DOI":"10.1371\/journal.pone.0071280","article-title":"Serum MMP-8: a novel indicator of left ventricular remodeling and cardiac outcome in patients after acute myocardial infarction","volume":"8","author":"Fertin","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0695","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1161\/01.RES.79.4.812","article-title":"Overexpression of tissue inhibitor of matrix metalloproteinase-1 inhibits vascular smooth muscle cell functions in vitro and in vivo","volume":"79","author":"Forough","year":"1996","journal-title":"Circ. Res."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0710","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1172\/JCI117619","article-title":"Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques","volume":"94","author":"Galis","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0700","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1161\/01.RES.75.1.181","article-title":"Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion","volume":"75","author":"Galis","year":"1994","journal-title":"Circ. Res."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0705","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1073\/pnas.92.2.402","article-title":"Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases","volume":"92","author":"Galis","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0715","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1038\/sj.gt.3300764","article-title":"Gene transfer of tissue inhibitor of metalloproteinase-2 inhibits metalloproteinase activity and neointima formation in human saphenous veins","volume":"5","author":"George","year":"1998","journal-title":"Gene Ther."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0720","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1089\/hum.1998.9.6-867","article-title":"Adenovirus-mediated gene transfer of the human TIMP-1 gene inhibits smooth muscle cell migration and neointimal formation in human saphenous vein","volume":"9","author":"George","year":"1998","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0725","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1161\/01.CIR.101.3.296","article-title":"Inhibition of late vein graft neointima formation in human and porcine models by adenovirus-mediated overexpression of tissue inhibitor of metalloproteinase-3","volume":"101","author":"George","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0730","doi-asserted-by":"crossref","first-page":"S135","DOI":"10.1161\/CIRCULATIONAHA.110.012732","article-title":"Sustained reduction of vein graft neointima formation by ex vivo TIMP-3 gene therapy","volume":"124","author":"George","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0005","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0092-8674(01)00238-0","article-title":"Atherosclerosis. the road ahead","volume":"104","author":"Glass","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0010","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1161\/ATVBAHA.110.206573","article-title":"Atherosclerosis and abdominal aortic aneurysm: cause, response, or common risk factors?","volume":"30","author":"Golledge","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0015","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1172\/JCI32750","article-title":"Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice","volume":"118","author":"Gong","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0020","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1172\/JCI25074","article-title":"Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice","volume":"116","author":"Gough","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0025","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1021\/jm980112p","article-title":"Bis-substituted malonic acid hydroxamate derivatives as inhibitors of human neutrophil collagenase (MMP8)","volume":"41","author":"Graf von","year":"1998","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0030","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1021\/jm9706426","article-title":"Design and synthesis of malonic acid-based inhibitors of human neutrophil collagenase (MMP8)","volume":"41","author":"Graf von","year":"1998","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0035","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1056\/NEJMcp1214999","article-title":"Clinical practice. Carotid stenosis","volume":"369","author":"Grotta","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0040","doi-asserted-by":"crossref","first-page":"10048","DOI":"10.1016\/S0021-9258(18)61073-7","article-title":"The collagen substrate specificity of human neutrophil collagenase","volume":"262","author":"Hasty","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0045","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jvs.2006.09.051","article-title":"Gender-associated differences in plaque phenotype of patients undergoing carotid endarterectomy","volume":"45","author":"Hellings","year":"2007","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0050","doi-asserted-by":"crossref","first-page":"8154","DOI":"10.1073\/pnas.88.18.8154","article-title":"Localization of stromelysin gene expression in atherosclerotic plaques by in situ hybridization","volume":"88","author":"Henney","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0055","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1161\/hc4101.097419","article-title":"Expression of neutrophil collagenase (matrix metalloproteinase-8) in human atheroma: a novel collagenolytic pathway suggested by transcriptional profiling","volume":"104","author":"Herman","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0060","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1053\/euhj.2000.2153","article-title":"Coronary in-stent restenosis\u2014predictors, treatment and prevention","volume":"21","author":"Hoffmann","year":"2000","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0065","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1161\/hq0801.093658","article-title":"Local gene transfer of tissue inhibitor of metalloproteinase-2 influences vein graft remodeling in a mouse model","volume":"21","author":"Hu","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0070","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1172\/JCI19628","article-title":"Abundant progenitor cells in the adventitia contribute to atherosclerosis of vein grafts in ApoE-deficient mice","volume":"113","author":"Hu","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0075","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jacc.2006.02.055","article-title":"Effects of selective matrix metalloproteinase inhibitor (PG-116800) to prevent ventricular remodeling after myocardial infarction: results of the PREMIER (Prevention of Myocardial Infarction Early Remodeling) trial","volume":"48","author":"Hudson","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0080","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1302\/0301-620X.80B5.0800907","article-title":"Dupuytren's disease and frozen shoulder induced by treatment with a matrix metalloproteinase inhibitor","volume":"80","author":"Hutchinson","year":"1998","journal-title":"J. Bone Joint Surg. (Br.)"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0085","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1161\/ATVBAHA.109.190314","article-title":"High levels of myeloid-related protein 14 in human atherosclerotic plaques correlate with the characteristics of rupture-prone lesions","volume":"29","author":"Ionita","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0090","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1161\/CIRCULATIONAHA.106.613281","article-title":"Suppression of atherosclerotic plaque progression and instability by tissue inhibitor of metalloproteinase-2: involvement of macrophage migration and apoptosis","volume":"113","author":"Johnson","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0095","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1161\/ATVBAHA.110.219147","article-title":"A selective matrix metalloproteinase-12 inhibitor retards atherosclerotic plaque development in apolipoprotein E-knockout mice","volume":"31","author":"Johnson","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0100","doi-asserted-by":"crossref","first-page":"15575","DOI":"10.1073\/pnas.0506201102","article-title":"Divergent effects of matrix metalloproteinases 3, 7, 9, and 12 on atherosclerotic plaque stability in mouse brachiocephalic arteries","volume":"102","author":"Johnson","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0105","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1161\/01.ATV.0000157582.33180.a9","article-title":"Stent-based delivery of tissue inhibitor of metalloproteinase-3 adenovirus inhibits neointimal formation in porcine coronary arteries","volume":"25","author":"Johnson","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0110","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1160\/TH04-08-0522","article-title":"Myocardial extra-cellular matrix and its regulation by metalloproteinases and their inhibitors","volume":"93","author":"Kassiri","year":"2005","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0115","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1161\/01.RES.0000178789.16929.cf","article-title":"Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice","volume":"97","author":"Kassiri","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0120","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1253\/circj.69.1035","article-title":"Plasma matrix metalloproteinase-8 concentrations are associated with the presence and severity of coronary artery disease","volume":"69","author":"Kato","year":"2005","journal-title":"Circ. J."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0125","first-page":"405","article-title":"Increased tissue factor, MMP-8, and D-dimer expression in diabetic patients with unstable advanced carotid atherosclerosis","volume":"3","author":"Krupinski","year":"2007","journal-title":"Vasc. Health Risk Manag."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0135","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1161\/CIRCRESAHA.109.200279","article-title":"A role of matrix metalloproteinase-8 in atherosclerosis","volume":"105","author":"Laxton","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0130","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/sj.gene.6364236","article-title":"Association of the lymphotoxin-alpha gene Thr26Asn polymorphism with severity of coronary atherosclerosis","volume":"6","author":"Laxton","year":"2005","journal-title":"Genes Immun."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0145","doi-asserted-by":"crossref","first-page":"e99","DOI":"10.1016\/j.jss.2010.05.030","article-title":"The prominent expression of plasma matrix metalloproteinase-8 in acute thoracic aortic dissection","volume":"163","author":"Li","year":"2010","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0140","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S0008-6363(00)00028-6","article-title":"MMP\/TIMP expression in spontaneously hypertensive heart failure rats: the effect of ACE- and MMP-inhibition","volume":"46","author":"Li","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0150","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/nm0195-17","article-title":"Lesion versus lumen","volume":"1","author":"Libby","year":"1995","journal-title":"Nat. Med."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0155","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1161\/01.CIR.91.11.2844","article-title":"Molecular bases of the acute coronary syndromes","volume":"91","author":"Libby","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0160","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis","volume":"420","author":"Libby","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0165","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1161\/hc0602.103674","article-title":"Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction","volume":"105","author":"Lindsey","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0170","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1172\/JCI0215334","article-title":"Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms","volume":"110","author":"Longo","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0175","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1159\/000025750","article-title":"The synthetic metalloproteinase inhibitor batimastat suppresses injury-induced phosphorylation of MAP kinase ERK1\/ERK2 and phenotypic modification of arterial smooth muscle cells in vitro","volume":"37","author":"Lovdahl","year":"2000","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0180","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1161\/01.ATV.0000058404.92759.32","article-title":"Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms","volume":"23","author":"Manning","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0185","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0021-9150(02)00035-7","article-title":"Metalloproteinase inhibitor attenuates neointima formation and constrictive remodeling after angioplasty in rats: augmentative effect of alpha(v)beta(3) receptor blockade","volume":"163","author":"Margolin","year":"2002","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0190","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1182\/blood-2004-06-2382","article-title":"Membrane type 1-matrix metalloproteinase is involved in migration of human monocytes and is regulated through their interaction with fibronectin or endothelium","volume":"105","author":"Matias-Roman","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0195","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/0741-5214(87)90274-6","article-title":"Collagen in abdominal aortic aneurysm: typing, content, and degradation","volume":"6","author":"Menashi","year":"1987","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0200","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1161\/01.CIR.0000135588.65188.14","article-title":"Unstable carotid plaques exhibit raised matrix metalloproteinase-8 activity","volume":"110","author":"Molloy","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0210","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.atherosclerosis.2009.07.037","article-title":"High plasma levels of matrix metalloproteinase-8 in patients with unstable angina","volume":"209","author":"Momiyama","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0215","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/S0741-5214(99)70281-8","article-title":"Suppression of experimental abdominal aortic aneurysms by systemic treatment with a hydroxamate-based matrix metalloproteinase inhibitor (RS 132908)","volume":"29","author":"Moore","year":"1999","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0220","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1161\/CIRCULATIONAHA.105.578955","article-title":"Neovascularization in human atherosclerosis","volume":"113","author":"Moreno","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0225","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1161\/01.CIR.0000046449.36178.00","article-title":"Myocardial infarct expansion and matrix metalloproteinase inhibition","volume":"107","author":"Mukherjee","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0230","first-page":"1475","article-title":"Non-peptidic cysteine derivatives as inhibitors of matrix metalloproteinases","volume":"378","author":"Muller","year":"1997","journal-title":"Biol. Chem."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0235","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.cardiores.2005.12.002","article-title":"Structure and function of matrix metalloproteinases and TIMPs","volume":"69","author":"Nagase","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0240","doi-asserted-by":"crossref","first-page":"21491","DOI":"10.1074\/jbc.274.31.21491","article-title":"Matrix metalloproteinases","volume":"274","author":"Nagase","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0245","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1161\/01.CIR.0000087481.55887.C9","article-title":"From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part II","volume":"108","author":"Naghavi","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0250","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1161\/01.CIR.0000087480.94275.97","article-title":"From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part I","volume":"108","author":"Naghavi","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.00048.2003","article-title":"Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture","volume":"85","author":"Newby","year":"2005","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0260","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.cardiores.2005.08.002","article-title":"Matrix metalloproteinases regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates","volume":"69","author":"Newby","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0265","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1161\/ATVBAHA.108.173898","article-title":"Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instability","volume":"28","author":"Newby","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0270","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1093\/eurheartj\/eht159","article-title":"Trends in age-specific coronary heart disease mortality in the European Union over three decades: 1980-2009","volume":"34","author":"Nichols","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0275","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1161\/01.CIR.92.6.1393","article-title":"Interstitial collagenase (MMP-1) expression in human carotid atherosclerosis","volume":"92","author":"Nikkari","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0280","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1016\/j.bbagen.2014.03.007","article-title":"Matrix metalloproteinases in inflammation","volume":"1840","author":"Nissinen","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0285","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ijcard.2014.04.096","article-title":"2014 global geographic analysis of mortality from ischaemic heart disease by country, age and income: statistics from World Health Organisation and United Nations","volume":"174","author":"Nowbar","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0290","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nrm2125","article-title":"Matrix metalloproteinases and the regulation of tissue remodelling","volume":"8","author":"Page-McCaw","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0295","series-title":"Collagenase matrix metalloproteinase-8 expressed in atherosclerotic carotid plaques is associated with systemic cardiovascular outcome","author":"Peeters","year":"2011"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0300","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0008-6363(00)00029-8","article-title":"Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat","volume":"46","author":"Peterson","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0305","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1161\/01.CIR.81.4.1161","article-title":"Ventricular remodeling after myocardial infarction Experimental observations and clinical implications.","volume":"81","author":"Pfeffer","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0310","series-title":"An Introduction to Vascular Biology","first-page":"166","article-title":"Abdominal aortic aneurysm","author":"Powell","year":"1998"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0315","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1177\/1753425911423852","article-title":"Single nucleotide polymorphism \u2212799C\/T in matrix metalloproteinase-8 promoter region in arterial disease","volume":"18","author":"Pradhan-Palikhe","year":"2012","journal-title":"Innate. Immun."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0320","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1365-3083.2010.02418.x","article-title":"Elevated MMP-8 and decreased myeloperoxidase concentrations associate significantly with the risk for peripheral atherosclerosis disease and abdominal aortic aneurysm","volume":"72","author":"Pradhan-Palikhe","year":"2010","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0325","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.ijcard.2011.12.095","article-title":"The balance of serum matrix metalloproteinase-8 and its tissue inhibitor in acute coronary syndrome and its recurrence","volume":"167","author":"Pussinen","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0330","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1172\/JCI8931","article-title":"Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms","volume":"105","author":"Pyo","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0335","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1161\/ATVBAHA.111.231563","article-title":"Selective inhibition of matrix metalloproteinase-13 increases collagen content of established mouse atherosclerosis","volume":"31","author":"Quillard","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0340","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1161\/01.CIR.99.24.3103","article-title":"Membrane type 1 matrix metalloproteinase expression in human atherosclerotic plaques: evidence for activation by proinflammatory mediators","volume":"99","author":"Rajavashisth","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0345","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0741-5214(89)90409-6","article-title":"Collagen types and matrix protein content in human abdominal aortic aneurysms","volume":"10","author":"Rizzo","year":"1989","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0350","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1161\/01.CIR.99.23.3063","article-title":"Matrix metalloproteinase inhibition attenuates early left ventricular enlargement after experimental myocardial infarction in mice","volume":"99","author":"Rohde","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0355","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/362801a0","article-title":"The pathogenesis of atherosclerosis: a perspective for the 1990s","volume":"362","author":"Ross","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0360","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis\u2013an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0365","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1161\/01.CIR.100.5.533","article-title":"Adenovirus-mediated overexpression of tissue inhibitor of metalloproteinase-1 reduces atherosclerotic lesions in apolipoprotein E-deficient mice","volume":"100","author":"Rouis","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0370","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1161\/01.STR.0000196986.50059.e0","volume":"37","author":"Sluijter","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0375","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1161\/01.CIR.102.16.1944","article-title":"A matrix metalloproteinase induction\/activation system exists in the human left ventricular myocardium and is upregulated in heart failure","volume":"102","author":"Spinale","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0380","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1161\/01.ATV.12.1.120","article-title":"A definition of the intima of human arteries and of its atherosclerosis- prone regions. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association","volume":"12","author":"Stary","year":"1992","journal-title":"Arterioscler. Thromb."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0390","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1161\/01.CIR.89.5.2462","article-title":"A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association","volume":"89","author":"Stary","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0385","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1161\/01.CIR.92.5.1355","article-title":"A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association","volume":"92","author":"Stary","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0395","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev.cellbio.17.1.463","article-title":"How matrix metalloproteinases regulate cell behavior","volume":"17","author":"Sternlicht","year":"2001","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0400","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1161\/01.CIR.99.19.2503","article-title":"Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques","volume":"99","author":"Sukhova","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0405","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1749-6632.1996.tb33307.x","article-title":"Role of matrix metalloproteinases in abdominal aortic aneurysms","volume":"800","author":"Thompson","year":"1996","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0410","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0959-8049(99)00007-6","article-title":"A pilot study of the safety and effects of the matrix metalloproteinase inhibitor marimastat in gastric cancer","volume":"35","author":"Tierney","year":"1999","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0415","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1177\/2047487312465524","article-title":"Serum tissue-degrading proteinases and incident cardiovascular disease events","volume":"21","author":"Tuomainen","year":"2012","journal-title":"Eur. J. Prev. Cardiol."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0420","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1161\/ATVBAHA.107.154831","article-title":"Serum matrix metalloproteinase-8 concentrations are associated with cardiovascular outcome in men","volume":"27","author":"Tuomainen","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0425","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.atherosclerosis.2005.08.039","article-title":"Intraplaque MMP-8 levels are increased in asymptomatic patients with carotid plaque progression on ultrasound","volume":"187","author":"Turu","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0430","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1006\/jmcc.1996.0132","article-title":"Post-transcriptional regulation of extracellular matrix metalloproteinase in human heart end-stage failure secondary to ischemic cardiomyopathy","volume":"28","author":"Tyagi","year":"1996","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0435","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cytogfr.2006.04.001","article-title":"Matrix metalloproteinase-8: cleavage can be decisive","volume":"17","author":"Van Lint","year":"2006","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0440","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.jvs.2005.08.009","article-title":"Carotid atherosclerotic plaques in patients with transient ischemic attacks and stroke have unstable characteristics compared with plaques in asymptomatic and amaurosis fugax patients","volume":"42","author":"Verhoeven","year":"2005","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0445","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1161\/01.STR.0000231685.82795.e5","article-title":"Statin treatment is not associated with consistent alterations in inflammatory status of carotid atherosclerotic plaques: a retrospective study in 378 patients undergoing carotid endarterectomy","volume":"37","author":"Verhoeven","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0450","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1161\/01.RES.0000070112.80711.3D","article-title":"Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry","volume":"92","author":"Visse","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0455","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.atherosclerosis.2008.04.050","article-title":"Effects of PDGF-C and PDGF-D on monocyte migration and MMP-2 and MMP-9 expression","volume":"202","author":"Wagsater","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0460","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1093\/hmg\/ddh287","article-title":"Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM)","volume":"13","author":"Wang","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0465","doi-asserted-by":"crossref","first-page":"25C","DOI":"10.1016\/S0002-9149(01)01539-9","article-title":"Angiotensin II and atherosclerosis","volume":"87","author":"Weiss","year":"2001","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0470","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1161\/01.CIR.0000068375.40887.FA","article-title":"Region- and type-specific induction of matrix metalloproteinases in post-myocardial infarction remodeling","volume":"107","author":"Wilson","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0475","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/bjs.4993","article-title":"Matrix metalloproteinase 8 (neutrophil collagenase) in the pathogenesis of abdominal aortic aneurysm","volume":"92","author":"Wilson","year":"2005","journal-title":"Br. J. Surg."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0485","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/CIRCRESAHA.112.274019","article-title":"Functional role of matrix metalloproteinase-8 in stem\/progenitor cell migration and their recruitment into atherosclerotic lesions","volume":"112","author":"Xiao","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0480","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1161\/ATVBAHA.113.301418","article-title":"Matrix metalloproteinase-8 promotes vascular smooth muscle cell proliferation and neointima formation","volume":"34","author":"Xiao","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0490","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/ncpcardio0396","article-title":"The impact of progenitor cells in atherosclerosis","volume":"3","author":"Xu","year":"2006","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0495","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/eurheartj\/ehr205","article-title":"Prevalence of cardiovascular disease risk factor in the Chinese population: the 2007-2008 China National Diabetes and Metabolic Disorders Study","volume":"33","author":"Yang","year":"2012","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.pharmthera.2014.11.007_bb0500","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1161\/01.CIR.0000091087.78630.79","article-title":"Selective targeting and timing of matrix metalloproteinase inhibition in post-myocardial infarction remodeling","volume":"108","author":"Yarbrough","year":"2003","journal-title":"Circulation"}],"container-title":["Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725814002071?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725814002071?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:51:35Z","timestamp":1759009895000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725814002071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":144,"alternative-id":["S0163725814002071"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2014.11.007","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Putative targeting of matrix metalloproteinase-8 in atherosclerosis","name":"articletitle","label":"Article Title"},{"value":"Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmthera.2014.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}