{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:28:19Z","timestamp":1791307699224,"version":"4.3.1"},"reference-count":301,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["1021973"],"award-info":[{"award-number":["1021973"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.pharmthera.2014.11.009","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T21:18:01Z","timestamp":1416518281000},"page":"1-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":302,"special_numbering":"C","title":["Cannabis and adolescent brain development"],"prefix":"10.1016","volume":"148","author":[{"given":"Dan I.","family":"Lubman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Cheetham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Y\u00fccel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb0005","doi-asserted-by":"crossref","first-page":"e31731","DOI":"10.1371\/journal.pone.0031731","article-title":"Short- and long-term cognitive effects of chronic cannabinoids administration in late-adolescence rats","volume":"7","author":"Abush","year":"2012","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.pharmthera.2014.11.009_bb0010","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1001\/archgenpsychiatry.2011.2273","article-title":"Cannabinoid receptor (CNR1) genotype moderates the effects of childhood physical abuse on anhedonia and depression","volume":"69","author":"Agrawal","year":"2012","journal-title":"Arch Gen Psychiatry"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0015","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.schres.2007.06.001","article-title":"Changing incidence of psychotic disorders among the young in Zurich","volume":"95","author":"Ajdacic-Gross","year":"2007","journal-title":"Schizophr Res"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0020","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/acps.12108","article-title":"Psychosis\u2010inducing effects of cannabis are related to both childhood abuse and COMT genotypes","volume":"129","author":"Alemany","year":"2014","journal-title":"Acta Psychiatr Scand"},{"issue":"6","key":"10.1016\/j.pharmthera.2014.11.009_bb0025","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1203\/PDR.0b013e318186e5dd","article-title":"Neuroprotective effects of the nonpsychoactive cannabinoid cannabidiol in hypoxic\u2013ischemic newborn piglets","volume":"64","author":"Alvarez","year":"2008","journal-title":"Pediatr Res"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb0030","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbr.2009.09.021","article-title":"Long-term consequences of a single treatment of mice with an ultra-low dose of \u03949-tetrahydrocannabinol (THC)","volume":"206","author":"Amal","year":"2010","journal-title":"Behav Brain Res"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb0035","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/02791072.1998.10399692","article-title":"High resolution brain SPECT imaging of marijuana smokers with AD\/HD","volume":"30","author":"Amen","year":"1998","journal-title":"J Psychoactive Drugs"},{"issue":"12","key":"10.1016\/j.pharmthera.2014.11.009_bb0040","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1093\/cercor\/bhi076","article-title":"Prenatal exposure to the CB1 receptor agonist WIN 55,212-2 causes learning disruption associated with impaired cortical NMDA receptor function and emotional reactivity changes in rat offspring","volume":"15","author":"Antonelli","year":"2005","journal-title":"Cereb Cortex"},{"issue":"6","key":"10.1016\/j.pharmthera.2014.11.009_bb0045","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1111\/j.1460-9568.2007.05782.x","article-title":"Cannabinoids modulate Olig2 and polysialylated neural cell adhesion molecule expression in the subventricular zone of post\u2010natal rats through cannabinoid receptor 1 and cannabinoid receptor 2","volume":"26","author":"Ar\u00e9valo\u2010Mart\u00edn","year":"2007","journal-title":"Eur J Neurosci"},{"issue":"32","key":"10.1016\/j.pharmthera.2014.11.009_bb0050","doi-asserted-by":"crossref","first-page":"5113","DOI":"10.2174\/138161212802884726","article-title":"The yin and yang of cannabis-induced psychosis: the actions of \u0394(9)-tetrahydrocannabinol and cannabidiol in rodent models of schizophrenia","volume":"18","author":"Arnold","year":"2012","journal-title":"Curr Pharm Des"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0055","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.neuroimage.2008.02.064","article-title":"Corpus callosum damage in heavy marijuana use: preliminary evidence from diffusion tensor tractography and tract-based spatial statistics","volume":"41","author":"Arnone","year":"2008","journal-title":"Neuroimage"},{"issue":"7374","key":"10.1016\/j.pharmthera.2014.11.009_bb0060","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1136\/bmj.325.7374.1212","article-title":"Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study","volume":"325","author":"Arseneault","year":"2002","journal-title":"BMJ"},{"issue":"8","key":"10.1016\/j.pharmthera.2014.11.009_bb0065","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.jpsychires.2011.01.004","article-title":"Medial temporal structures and memory functions in adolescents with heavy cannabis use","volume":"45","author":"Ashtari","year":"2011","journal-title":"J Psychiatr Res"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0070","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jpsychires.2008.12.002","article-title":"Diffusion abnormalities in adolescents and young adults with a history of heavy cannabis use","volume":"43","author":"Ashtari","year":"2009","journal-title":"J Psychiatr Res"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0075","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.bbr.2011.02.005","article-title":"Pre- and post-conditioning treatment with an ultra-low dose of \u03949-tetrahydrocannabinol (THC) protects against pentylenetetrazole (PTZ)-induced cognitive damage","volume":"220","author":"Assaf","year":"2011","journal-title":"Behav Brain Res"},{"issue":"9","key":"10.1016\/j.pharmthera.2014.11.009_bb0080","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.1073\/pnas.1200742109","article-title":"Glucocorticoids interact with the hippocampal endocannabinoid system in impairing retrieval of contextual fear memory","volume":"109","author":"Atsak","year":"2012","journal-title":"Proc Natl Acad Sci"},{"issue":"8","key":"10.1016\/j.pharmthera.2014.11.009_bb0085","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/j.neubiorev.2013.06.015","article-title":"A systematic review of diffusion weighted MRI studies of white matter microstructure in adolescent substance users","volume":"37","author":"Baker","year":"2013","journal-title":"Neurosci Biobehav Rev"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0090","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.nbd.2009.11.020","article-title":"Chronic exposure to cannabinoids during adolescence but not during adulthood impairs emotional behaviour and monoaminergic neurotransmission","volume":"37","author":"Bambico","year":"2010","journal-title":"Neurobiol Dis"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb0095","doi-asserted-by":"crossref","first-page":"e55821","DOI":"10.1371\/journal.pone.0055821","article-title":"Structural and functional imaging studies in chronic cannabis users: a systematic review of adolescent and adult findings","volume":"8","author":"Batalla","year":"2013","journal-title":"PLoS One"},{"issue":"s1","key":"10.1016\/j.pharmthera.2014.11.009_bb0100","doi-asserted-by":"crossref","first-page":"E181","DOI":"10.1111\/j.1530-0277.2012.01920.x","article-title":"Longitudinal changes in white matter integrity among adolescent substance users","volume":"37","author":"Bava","year":"2013","journal-title":"Alcohol Clin Exp Res"},{"issue":"6","key":"10.1016\/j.pharmthera.2014.11.009_bb0105","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0022-3956(99)00039-4","article-title":"Genetic and non-genetic vulnerability factors in schizophrenia: the basis of the \u201ctwo hit hypothesis\u201d","volume":"33","author":"Bayer","year":"1999","journal-title":"J Psychiatr Res"},{"issue":"6","key":"10.1016\/j.pharmthera.2014.11.009_bb0110","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/npp.2011.6","article-title":"Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naive social phobia patients","volume":"36","author":"Bergamaschi","year":"2011","journal-title":"Neuropsychopharmacology"},{"issue":"16","key":"10.1016\/j.pharmthera.2014.11.009_bb0115","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1242\/dev.125.16.3179","article-title":"Localization of mRNA expression and activation of signal transduction mechanisms for cannabinoid receptor in rat brain during fetal development","volume":"125","author":"Berrendero","year":"1998","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0120","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/00001756-200002280-00013","article-title":"Effects of frequent marijuana use on brain tissue volume and composition","volume":"11","author":"Block","year":"2000","journal-title":"Neuroreport"},{"issue":"9","key":"10.1016\/j.pharmthera.2014.11.009_bb0125","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1212\/01.WNL.0000031422.66442.49","article-title":"Dose-related neurocognitive effects of marijuana use","volume":"59","author":"Bolla","year":"2002","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0130","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.pneurobio.2010.06.010","article-title":"Adolescent brain maturation, the endogenous cannabinoid system and the neurobiology of cannabis-induced schizophrenia","volume":"92","author":"Bossong","year":"2010","journal-title":"Prog Neurobiol"},{"issue":"10","key":"10.1016\/j.pharmthera.2014.11.009_bb0135","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1017\/S0033291706008440","article-title":"Trends in cannabis use prior to first presentation with schizophrenia, in south-east London between 1965 and 1999","volume":"36","author":"Boydell","year":"2006","journal-title":"Psychol Med"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb0140","first-page":"1","article-title":"Chronic cannabinoid treatment in adolescence attenuates c-Fos expression in nucleus accumbens of adult estrous rats","author":"Brook","year":"2013","journal-title":"Impulse"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb0145","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/toxsci\/kfq103","article-title":"Long-term consequences of fetal and neonatal nicotine exposure: a critical review","volume":"116","author":"Bruin","year":"2010","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb0150","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3389\/fphar.2012.00101","article-title":"Association of cannabis use during adolescence, prefrontal CB1 receptor signaling, and schizophrenia","volume":"3","author":"Caballero","year":"2012","journal-title":"Front Pharmacol"},{"issue":"5","key":"10.1016\/j.pharmthera.2014.11.009_bb0160","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/S0028-3908(00)00210-0","article-title":"Tetrahydrocannabinol-induced apoptosis of cultured cortical neurones is associated with cytochrome c release and caspase-3 activation","volume":"40","author":"Campbell","year":"2001","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0155","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/S0022-3565(25)23358-4","article-title":"\u03949-Tetrahydrocannabinol differentially affects sensory-evoked potentials in the rat dentate gyrus","volume":"239","author":"Campbell","year":"1986","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb0165","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00213-008-1168-x","article-title":"Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats","volume":"199","author":"Campos","year":"2008","journal-title":"Psychopharmacology (Berl)"},{"issue":"1607","key":"10.1016\/j.pharmthera.2014.11.009_bb0170","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1098\/rstb.2011.0389","article-title":"Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders","volume":"367","author":"Campos","year":"2012","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"06","key":"10.1016\/j.pharmthera.2014.11.009_bb0175","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1017\/S1461145712001502","article-title":"The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system","volume":"16","author":"Campos","year":"2013","journal-title":"Int J Neuropsychopharmacol"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb0180","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.toxicon.2004.05.009","article-title":"The good and the bad effects of -trans-\u03949-tetrahydrocannabinol (\u03949THC) on humans","volume":"44","author":"Carlini","year":"2004","journal-title":"Toxicon"},{"issue":"10","key":"10.1016\/j.pharmthera.2014.11.009_bb0185","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.biopsych.2005.01.026","article-title":"Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene\u00d7environment interaction","volume":"57","author":"Caspi","year":"2005","journal-title":"Biol Psychiatry"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0190","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.neuropharm.2007.05.019","article-title":"Prenatal exposure to the cannabinoid receptor agonist WIN 55,212-2 increases glutamate uptake through overexpression of GLT1 and EAAC1 glutamate transporter subtypes in rat frontal cerebral cortex","volume":"53","author":"Castaldo","year":"2007","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0195","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s12035-007-0022-1","article-title":"Group I metabotropic glutamate receptors: a role in neurodevelopmental disorders?","volume":"35","author":"Catania","year":"2007","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb0200","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.neuroimage.2013.04.052","article-title":"Increased ventral striatal CB1 receptor binding is related to negative symptoms in drug-free patients with schizophrenia","volume":"79","author":"Ceccarini","year":"2013","journal-title":"Neuroimage"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0205","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.pbb.2006.03.006","article-title":"Differential effects of \u03949THC on learning in adolescent and adult rats","volume":"83","author":"Cha","year":"2006","journal-title":"Pharmacol Biochem Behav"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0210","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.pbb.2011.07.006","article-title":"Adolescent cannabinoid exposure attenuates adult female sexual motivation but does not alter adulthood CB1R expression or estrous cyclicity","volume":"100","author":"Chadwick","year":"2011","journal-title":"Pharmacol Biochem Behav"},{"issue":"8","key":"10.1016\/j.pharmthera.2014.11.009_bb0215","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.biopsych.2011.10.029","article-title":"Orbitofrontal volumes in early adolescence predict initiation of cannabis use: a 4-year longitudinal and prospective study","volume":"71","author":"Cheetham","year":"2012","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb0220","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyg.2010.00225","article-title":"Altered frontal cortical volume and decision making in adolescent cannabis users","volume":"1","author":"Churchwell","year":"2010","journal-title":"Front Psychol"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0225","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1360-0443.2011.03566.x","article-title":"Psychological dysregulation, white matter disorganization and substance use disorders in adolescence","volume":"107","author":"Clark","year":"2012","journal-title":"Addiction"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb0230","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.schres.2014.04.026","article-title":"White matter changes in early phase schizophrenia and cannabis use: an update and systematic review of diffusion tensor imaging studies","volume":"156","author":"Cookey","year":"2014","journal-title":"Schizophr Res"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb9000","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/ADM.0b013e31820c23fa","article-title":"An evidence based review of acute and long-term effects of cannabis use on executive cognitive functions","volume":"5","author":"Crean","year":"2011","journal-title":"J Addict Med"},{"issue":"7","key":"10.1016\/j.pharmthera.2014.11.009_bb0235","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/hup.1048","article-title":"Cannabis and anxiety: a critical review of the evidence","volume":"24","author":"Crippa","year":"2009","journal-title":"Hum Psychopharmacol"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb0245","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s00213-008-1333-2","article-title":"Preliminary evidence of cannabinoid effects on brain-derived neurotrophic factor (BDNF) levels in humans","volume":"202","author":"D'Souza","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"issue":"11","key":"10.1016\/j.pharmthera.2014.11.009_bb0250","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/syn.20801","article-title":"Cannabinoid effects on CB1 receptor density in the adolescent brain: an autoradiographic study using the synthetic cannabinoid HU210","volume":"64","author":"Dalton","year":"2010","journal-title":"Synapse"},{"issue":"11","key":"10.1016\/j.pharmthera.2014.11.009_bb0255","doi-asserted-by":"crossref","first-page":"E979","DOI":"10.1073\/pnas.1218571110","article-title":"Personality may explain the association between cannabis use and neuropsychological impairment","volume":"110","author":"Daly","year":"2013","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0260","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ntt.2010.07.006","article-title":"The effects of prenatal marijuana exposure on delinquent behaviors are mediated by measures of neurocognitive functioning","volume":"33","author":"Day","year":"2011","journal-title":"Neurotoxicol Teratol"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nlm.2008.01.009","article-title":"Differential role of the hippocampal endocannabinoid system in the memory consolidation and retrieval mechanisms","volume":"90","author":"De Oliveira Alvares","year":"2008","journal-title":"Neurobiol Learn Mem"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.beem.2008.10.013","article-title":"An introduction to the endocannabinoid system: from the early to the latest concepts","volume":"23","author":"De Petrocellis","year":"2009","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0275","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0306-4522(00)00552-2","article-title":"Studies on [3H] CP-55940 binding in the human central nervous system: regional specific changes in density of cannabinoid-1 receptors associated with schizophrenia and cannabis use","volume":"103","author":"Dean","year":"2001","journal-title":"Neuroscience"},{"issue":"11","key":"10.1016\/j.pharmthera.2014.11.009_bb0280","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1046\/j.1360-0443.2003.00437.x","article-title":"Exploring the association between cannabis use and depression","volume":"98","author":"Degenhardt","year":"2003","journal-title":"Addiction"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0285","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1477-7517-3-17","article-title":"A preliminary DTI study showing no brain structural change associated with adolescent cannabis use","volume":"3","author":"DeLisi","year":"2006","journal-title":"Harm Reduct J"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb0290","first-page":"242","article-title":"Diminished gray matter in the hippocampus of cannabis users: possible protective effects of cannabidiol","volume":"114","author":"Demirakca","year":"2011","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb0295","first-page":"441","article-title":"Neuroimaging of children following prenatal drug exposure","volume":"Vol. 20","author":"Derauf","year":"2009"},{"issue":"1607","key":"10.1016\/j.pharmthera.2014.11.009_bb0300","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1098\/rstb.2011.0385","article-title":"Endocannabinoids via CB1 receptors act as neurogenic niche cues during cortical development","volume":"367","author":"D\u00edaz-Alonso","year":"2012","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"10","key":"10.1016\/j.pharmthera.2014.11.009_bb0305","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.euroneuro.2008.05.003","article-title":"Cannabinoid receptor 1 (CNR1) gene: impact on antidepressant treatment response and emotion processing in major depression","volume":"18","author":"Domschke","year":"2008","journal-title":"Eur Neuropsychopharmacol"},{"issue":"18","key":"10.1016\/j.pharmthera.2014.11.009_bb0310","doi-asserted-by":"crossref","first-page":"3973","DOI":"10.1097\/00001756-200112210-00024","article-title":"\u03949-Tetrahydrocannabinol induces the apoptotic pathway in cultured cortical neurones via activation of the CB1 receptor","volume":"12","author":"Downer","year":"2001","journal-title":"Neuroreport"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0315","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1465-3362.2009.00102.x","article-title":"Phytocannabinoids, CNS cells and development: a dead issue?","volume":"29","author":"Downer","year":"2010","journal-title":"Drug Alcohol Rev"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb0320","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.brainres.2007.07.076","article-title":"A comparison of the apoptotic effect of \u03949-tetrahydrocannabinol in the neonatal and adult rat cerebral cortex","volume":"1175","author":"Downer","year":"2007","journal-title":"Brain Res"},{"issue":"8","key":"10.1016\/j.pharmthera.2014.11.009_bb0240","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1038\/sj.npp.1300496","article-title":"The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: implications for psychosis","volume":"29","author":"D'Souza","year":"2004","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0325","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1001\/archpedi.153.3.286","article-title":"The relationship between early age of onset of initial substance use and engaging in multiple health risk behaviors among young adolescents","volume":"153","author":"DuRant","year":"1999","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"5","key":"10.1016\/j.pharmthera.2014.11.009_bb0330","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.neubiorev.2005.12.002","article-title":"Cannabinoids and prefrontal cortical function: insights from preclinical studies","volume":"30","author":"Egerton","year":"2006","journal-title":"Neurosci Biobehav Rev"},{"issue":"10","key":"10.1016\/j.pharmthera.2014.11.009_bb0335","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1038\/npp.2010.75","article-title":"Cannabinoid CB1 receptor immunoreactivity in the prefrontal cortex: comparison of schizophrenia and major depressive disorder","volume":"35","author":"Eggan","year":"2010","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0345","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.drugalcdep.2008.05.010","article-title":"Demographic, emotional and social determinants of cannabis use in early pregnancy: the Generation R study","volume":"98","author":"el Marroun","year":"2008","journal-title":"Drug Alcohol Depend"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb0340","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.pbb.2010.03.004","article-title":"Antidepressant-like effect of \u03949-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L.","volume":"95","author":"El-Alfy","year":"2010","journal-title":"Pharmacol Biochem Behav"},{"issue":"6","key":"10.1016\/j.pharmthera.2014.11.009_bb0350","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1089\/neu.2010.1672","article-title":"Acute effects of a selective cannabinoid-2 receptor agonist on neuroinflammation in a model of traumatic brain injury","volume":"28","author":"Elliott","year":"2011","journal-title":"J Neurotrauma"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb0355","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0022-3956(82)90038-3","article-title":"Schizophrenia: caused by a fault in programmed synaptic elimination during adolescence?","volume":"17","author":"Feinberg","year":"1983","journal-title":"J Psychiatr Res"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0360","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1017\/S0033291702006402","article-title":"Cannabis dependence and psychotic symptoms in young people","volume":"33","author":"Fergusson","year":"2003","journal-title":"Psychol Med"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb0365","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.neuroscience.2012.01.008","article-title":"Reduced infarct size and accumulation of microglia in rats treated with WIN 55,212-2 after neonatal stroke","volume":"207","author":"Fern\u00e1ndez-L\u00f3pez","year":"2012","journal-title":"Neuroscience"},{"issue":"12","key":"10.1016\/j.pharmthera.2014.11.009_bb0370","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1161\/STROKEAHA.110.599357","article-title":"The cannabinoid WIN55212-2 promotes neural repair after neonatal hypoxia\u2013ischemia","volume":"41","author":"Fern\u00e1ndez-L\u00f3pez","year":"2010","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0375","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0091-3057(99)00106-9","article-title":"Learning impairment produced in rats by the cannabinoid agonist HU 210 in a water-maze task","volume":"64","author":"Ferrari","year":"1999","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb0380","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.rbp.2012.07.003","article-title":"The endocannabinoid system and its role in schizophrenia: a systematic review of the literature","volume":"34","author":"Ferretjans","year":"2012","journal-title":"Rev Bras Psiquiatr"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb0385","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00221-012-3186-5","article-title":"Long-term behavioral and biochemical effects of an ultra-low dose of \u03949-tetrahydrocannabinol (THC): neuroprotection and ERK signaling","volume":"221","author":"Fishbein","year":"2012","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb0390","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1192\/bjp.bp.110.077479","article-title":"Cannabis use before age 15 and subsequenct executive functioning","volume":"198","author":"Fontes","year":"2011","journal-title":"Br J Psychiatry"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb0395","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/syn.10089","article-title":"Dose\u2010dependent effects of \u03949\u2010tetrahydrocannabinol on rates of local cerebral glucose utilization in rat","volume":"45","author":"Freedland","year":"2002","journal-title":"Synapse"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0400","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1152\/physrev.00004.2003","article-title":"Role of endogenous cannabinoids in synaptic signaling","volume":"83","author":"Freund","year":"2003","journal-title":"Physiol Rev"},{"issue":"s1","key":"10.1016\/j.pharmthera.2014.11.009_bb0405","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1365-2826.2008.01670.x","article-title":"Multiple roles for the endocannabinoid system during the earliest stages of life: pre\u2010and postnatal development","volume":"20","author":"Fride","year":"2008","journal-title":"J Neuroendocrinol"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb0410","first-page":"49","article-title":"36- and 48-month neurobehavioral follow-up of children prenatally exposed to marijuana, cigarettes, and alcohol","volume":"11","author":"Fried","year":"1990","journal-title":"J Dev Behav Pediatr"},{"issue":"5","key":"10.1016\/j.pharmthera.2014.11.009_bb0415","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0892-0362(01)00160-X","article-title":"Differential effects on facets of attention in adolescents prenatally exposed to cigarettes and marihuana","volume":"23","author":"Fried","year":"2001","journal-title":"Neurotoxicol Teratol"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0420","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0892-0362(97)00091-3","article-title":"Differential effects on cognitive functioning 9- to 12-year olds prenatally exposed to cigarettes and marihuana","volume":"20","author":"Fried","year":"1998","journal-title":"Neurotoxicol Teratol"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb0425","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ntt.2004.11.003","article-title":"Neurocognitive consequences of marihuana\u2014a comparison with pre-drug performance","volume":"27","author":"Fried","year":"2005","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb0430","series-title":"Marijuana and Madness","first-page":"66","article-title":"Cannabis, endocannabinoids and neurodevelopment","author":"Galve-Roperh","year":"2012"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb0435","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1177\/1073858406296407","article-title":"The endocannabinoid system and neurogenesis in health and disease","volume":"13","author":"Galve-Roperh","year":"2007","journal-title":"Neuroscientist"},{"issue":"23","key":"10.1016\/j.pharmthera.2014.11.009_bb0440","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.2174\/138161208785740117","article-title":"Mechanisms of control of neuron survival by the endocannabinoid system","volume":"14","author":"Galve-Roperh","year":"2008","journal-title":"Curr Pharm Des"},{"issue":"7","key":"10.1016\/j.pharmthera.2014.11.009_bb0445","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00406-009-0028-y","article-title":"The endocannabinoid system and the regulation of neural development: potential implications in psychiatric disorders","volume":"259","author":"Galve-Roperh","year":"2009","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"issue":"10","key":"10.1016\/j.pharmthera.2014.11.009_bb0450","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/13158","article-title":"Brain development during childhood and adolescence: a longitudinal MRI study","volume":"2","author":"Giedd","year":"1999","journal-title":"Nat Neurosci"},{"issue":"5","key":"10.1016\/j.pharmthera.2014.11.009_bb0455","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/CHI.0b013e31819f2715","article-title":"Anatomical brain magnetic resonance imaging of typically developing children and adolescents","volume":"48","author":"Giedd","year":"2009","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb0460","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1177\/1359105307074240","article-title":"Critical review nicotine for the fetus, the infant and the adolescent?","volume":"12","author":"Ginzel","year":"2007","journal-title":"J Health Psychol"},{"issue":"11","key":"10.1016\/j.pharmthera.2014.11.009_bb0465","doi-asserted-by":"crossref","first-page":"e199","DOI":"10.1038\/tp.2012.122","article-title":"Susceptibility of the adolescent brain to cannabinoids: long-term hippocampal effects and relevance to schizophrenia","volume":"2","author":"Gleason","year":"2012","journal-title":"Transl Psychiatry"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0470","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0892-0362(00)00066-0","article-title":"Effects of prenatal marijuana exposure on child behavior problems at age 10","volume":"22","author":"Goldschmidt","year":"2000","journal-title":"Neurotoxicol Teratol"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb0475","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.ntt.2004.04.003","article-title":"Prenatal marijuana and alcohol exposure and academic achievement at age 10","volume":"26","author":"Goldschmidt","year":"2004","journal-title":"Neurotoxicol Teratol"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0480","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/CHI.0b013e318160b3f0","article-title":"Prenatal marijuana exposure and intelligence test performance at age 6","volume":"47","author":"Goldschmidt","year":"2008","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0485","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s11065-007-9036-8","article-title":"Acute and non-acute effects of cannabis on brain functioning and neuropsychological performance","volume":"17","author":"Gonzalez","year":"2007","journal-title":"Neuropsychol Rev"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb0490","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1176\/appi.ajp.160.4.636","article-title":"The endophenotype concept in psychiatry: etymology and strategic intentions","volume":"160","author":"Gottesman","year":"2003","journal-title":"Am J Psychiatry"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb0495","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1080\/09595230310001613976","article-title":"Being stoned: a review of self\u2010reported cannabis effects","volume":"22","author":"Green","year":"2003","journal-title":"Drug Alcohol Rev"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0500","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0009-3084(02)00161-5","article-title":"Assessment of cannabinoid induced gene changes: tolerance and neuroprotection","volume":"121","author":"Grigorenko","year":"2002","journal-title":"Chem Phys Lipids"},{"issue":"8","key":"10.1016\/j.pharmthera.2014.11.009_bb0505","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1007\/s00213-013-3326-z","article-title":"Worth the wait: effects of age of onset of marijuana use on white matter and impulsivity","volume":"231","author":"Gruber","year":"2014","journal-title":"Psychopharmacology (Berl)"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb9005","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1037\/a0026269","article-title":"Age of onset of marijuana use and executive function","volume":"26","author":"Gruber","year":"2012","journal-title":"Psychol Addict Behav"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0510","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1037\/a0023034","article-title":"Why so impulsive? White matter alterations are associated with impulsivity in chronic marijuana smokers","volume":"19","author":"Gruber","year":"2011","journal-title":"Exp Clin Psychopharmacol"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0515","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cogbrainres.2005.02.016","article-title":"Neuroimaging of marijuana smokers during inhibitory processing: a pilot investigation","volume":"23","author":"Gruber","year":"2005","journal-title":"Cogn Brain Res"},{"issue":"11","key":"10.1016\/j.pharmthera.2014.11.009_bb0520","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s001090000177","article-title":"Control of the cell survival\/death decision by cannabinoids","volume":"78","author":"Guzm\u00e1n","year":"2001","journal-title":"J Mol Med"},{"issue":"9698","key":"10.1016\/j.pharmthera.2014.11.009_bb0525","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/S0140-6736(09)61037-0","article-title":"Adverse health effects of non-medical cannabis use","volume":"374","author":"Hall","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb0530","series-title":"Cannabis Use and Dependence: Public Health and Public Policy","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511470219","author":"Hall","year":"2003"},{"issue":"11","key":"10.1016\/j.pharmthera.2014.11.009_bb0535","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.addbeh.2010.06.012","article-title":"Longitudinal study of cognition among adolescent marijuana users over three weeks of abstinence","volume":"35","author":"Hanson","year":"2010","journal-title":"Addict Behav"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0540","doi-asserted-by":"crossref","first-page":"S84","DOI":"10.1016\/j.mce.2008.02.011","article-title":"Endocannabinoid functions controlling neuronal specification during brain development","volume":"286","author":"Harkany","year":"2008","journal-title":"Mol Cell Endocrinol"},{"issue":"10","key":"10.1016\/j.pharmthera.2014.11.009_bb0545","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1017\/S0033291709991966","article-title":"Cannabis use and childhood trauma interact additively to increase the risk of psychotic symptoms in adolescence","volume":"40","author":"Harley","year":"2010","journal-title":"Psychol Med"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb0550","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/jnr.490030202","article-title":"Effects of Cannabis sativa on ultrastructure of the synapse in monkey brain","volume":"3","author":"Harper","year":"1977","journal-title":"J Neurosci Res"},{"issue":"5","key":"10.1016\/j.pharmthera.2014.11.009_bb0555","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0893-133X(01)00273-1","article-title":"Effects of acute smoked marijuana on complex cognitive performance","volume":"25","author":"Hart","year":"2001","journal-title":"Neuropsychopharmacology"},{"issue":"13","key":"10.1016\/j.pharmthera.2014.11.009_bb0560","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1073\/pnas.79.13.4217","article-title":"Development and maturation of central nervous system myelin: comparison of immunohistochemical localization of proteolipid protein and basic protein in myelin and oligodendrocytes","volume":"79","author":"Hartman","year":"1982","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0565","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1080\/09595230701247772","article-title":"The relationship between non-acute adolescent cannabis use and cognition","volume":"26","author":"Harvey","year":"2007","journal-title":"Drug Alcohol Rev"},{"issue":"5","key":"10.1016\/j.pharmthera.2014.11.009_bb0570","first-page":"657","article-title":"Cannabis sativa: effects on brain function and ultrastructure in rhesus monkeys","volume":"15","author":"Heath","year":"1980","journal-title":"Biol Psychiatry"},{"issue":"6","key":"10.1016\/j.pharmthera.2014.11.009_bb0575","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/schbul\/sbn108","article-title":"Gene\u2013environment interplay between cannabis and psychosis","volume":"34","author":"Henquet","year":"2008","journal-title":"Schizophr Bull"},{"issue":"5","key":"10.1016\/j.pharmthera.2014.11.009_bb0580","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1073\/pnas.87.5.1932","article-title":"Cannabinoid receptor localization in brain","volume":"87","author":"Herkenham","year":"1990","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0585","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1212\/01.WNL.0000150882.69371.DD","article-title":"Cerebrovascular perfusion in marijuana users during a month of monitored abstinence","volume":"64","author":"Herning","year":"2005","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0590","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0022-3565(25)10268-1","article-title":"Effects of delta-9-tetrahydrocannabinol on delayed match to sample performance in rats: alterations in short-term memory associated with changes in task specific firing of hippocampal cells","volume":"264","author":"Heyser","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb0595","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1360-0443.2006.01710.x","article-title":"Cannabis and schizophrenia: model projections of the impact of the rise in cannabis use on historical and future trends in schizophrenia in England and Wales","volume":"102","author":"Hickman","year":"2007","journal-title":"Addiction"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0600","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1111\/j.1460-9568.2004.03522.x","article-title":"Prolonged cannabinoid treatment results in spatial working memory deficits and impaired long\u2010term potentiation in the CA1 region of the hippocampus in vivo","volume":"20","author":"Hill","year":"2004","journal-title":"Eur J Neurosci"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0605","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1093\/schbul\/sbm127","article-title":"Childhood sexual abuse, early cannabis use, and psychosis: testing an interaction model based on the National Comorbidity Survey","volume":"34","author":"Houston","year":"2008","journal-title":"Schizophr Bull"},{"issue":"10","key":"10.1016\/j.pharmthera.2014.11.009_bb0610","doi-asserted-by":"crossref","first-page":"e77577","DOI":"10.1371\/journal.pone.0077577","article-title":"CB2 Receptor agonists protect human dopaminergic neurons against damage from HIV-1 gp120","volume":"8","author":"Hu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb0625","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.pnpbp.2013.09.014","article-title":"Prenatal cannabis exposure and infant outcomes: overview of studies","volume":"52","author":"Huizink","year":"2014","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0630","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neubiorev.2005.04.005","article-title":"Maternal smoking, drinking or cannabis use during pregnancy and neurobehavioral and cognitive functioning in human offspring","volume":"30","author":"Huizink","year":"2006","journal-title":"Neurosci Biobehav Rev"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb0615","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s11682-011-9134-3","article-title":"Toward dysfunctional connectivity: a review of neuroimaging findings in pediatric major depressive disorder","volume":"5","author":"Hulvershorn","year":"2011","journal-title":"Brain Imaging Behav"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb0620","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/sj.mp.4001376","article-title":"Upregulation of CB1 receptors and agonist-stimulated [35S] GTP\u03b3S binding in the prefrontal cortex of depressed suicide victims","volume":"9","author":"Hungund","year":"2004","journal-title":"Mol Psychiatry"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb0635","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s00213-004-1868-9","article-title":"Effects of marijuana on neurophysiological signals of working and episodic memory","volume":"176","author":"Ilan","year":"2004","journal-title":"Psychopharmacology (Berl)"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb0640","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.pbb.2009.04.001","article-title":"Functional consequences of marijuana use in adolescents","volume":"92","author":"Jacobus","year":"2009","journal-title":"Pharmacol Biochem Behav"},{"issue":"6","key":"10.1016\/j.pharmthera.2014.11.009_bb0650","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ntt.2009.07.006","article-title":"White matter integrity in adolescents with histories of marijuana use and binge drinking","volume":"31","author":"Jacobus","year":"2009","journal-title":"Neurotoxicol Teratol"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0655","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.pscychresns.2013.07.014","article-title":"White matter characterization of adolescent binge drinking with and without co-occurring marijuana use: a 3-year investigation","volume":"214","author":"Jacobus","year":"2013","journal-title":"Psychiatry Res Neuroimaging"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0660","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3390\/brainsci3010396","article-title":"White matter integrity pre- and post marijuana and alcohol initiation in adolescence","volume":"3","author":"Jacobus","year":"2013","journal-title":"Brain Sci"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb0665","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.euroneuro.2006.10.003","article-title":"Effects of frequent cannabis use on hippocampal activity during an associative memory task","volume":"17","author":"Jager","year":"2007","journal-title":"Eur Neuropsychopharmacol"},{"issue":"11","key":"10.1016\/j.pharmthera.2014.11.009_bb0670","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1172\/JCI25509","article-title":"Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects","volume":"115","author":"Jiang","year":"2005","journal-title":"J Clin Invest"},{"issue":"8","key":"10.1016\/j.pharmthera.2014.11.009_bb0675","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1038\/npp.2009.19","article-title":"CNR1 gene is associated with high neuroticism and low agreeableness and interacts with recent negative life events to predict current depressive symptoms","volume":"34","author":"Juhasz","year":"2009","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0680","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0022-3956(94)90009-4","article-title":"Is schizophrenia due to excessive synaptic pruning in the prefrontal cortex? The Feinberg hypothesis revisited","volume":"28","author":"Keshavan","year":"1994","journal-title":"J Psychiatr Res"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0685","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1152\/physiolgenomics.2000.3.3.175","article-title":"Large-scale analysis of gene expression changes during acute and chronic exposure to \u03949-THC in rats","volume":"3","author":"Kittler","year":"2000","journal-title":"Physiol Genomics"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb0690","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/sj.bjp.0705304","article-title":"Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid\u2010type CB2 receptor","volume":"139","author":"Klegeris","year":"2003","journal-title":"Br J Pharmacol"},{"issue":"5","key":"10.1016\/j.pharmthera.2014.11.009_bb0695","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nri1602","article-title":"Cannabinoid-based drugs as anti-inflammatory therapeutics","volume":"5","author":"Klein","year":"2005","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb9010","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bbr.2012.05.019","article-title":"Chronic cannabinoid treatment during young adulthood induces sex-specific behavioural deficits in maternally separated rats","volume":"233","author":"Klug","year":"2012","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb0700","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2013.00149","article-title":"An investigation into \u201ctwo hit\u201d effects of BDNF deficiency and young-adult cannabinoid receptor stimulation on prepulse inhibition regulation and memory in mice","volume":"7","author":"Klug","year":"2013","journal-title":"Front Behav Neurosci"},{"issue":"8","key":"10.1016\/j.pharmthera.2014.11.009_bb0705","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s00702-007-0660-5","article-title":"Expression of CB1 cannabinoid receptor in the anterior cingulate cortex in schizophrenia, bipolar disorder, and major depression","volume":"114","author":"Koethe","year":"2007","journal-title":"J Neural Transm"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb0710","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.d738","article-title":"Continued cannabis use and risk of incidence and persistence of psychotic symptoms: 10year follow-up cohort study","volume":"342","author":"Kuepper","year":"2011","journal-title":"Br Med J"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0715","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/0006-8993(90)91322-8","article-title":"Effect of early exposure to \u0394-9-tetrahydrocannabinol on the levels of opioid peptides, gonadotropin-releasing hormone and substance P in the adult male rat brain","volume":"525","author":"Kumar","year":"1990","journal-title":"Brain Res"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0720","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1203\/PDR.0b013e3182276b11","article-title":"Cannabidiol reduces brain damage and improves functional recovery after acute hypoxia\u2013ischemia in newborn pigs","volume":"70","author":"Lafuente","year":"2011","journal-title":"Pediatr Res"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0725","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0006-8993(88)91597-1","article-title":"Quantitative changes in hippocampal structure following long-term exposure to \u03949-tetrahydrocannabinol: possible mediation by glucocorticoid systems","volume":"443","author":"Landfield","year":"1988","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0730","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1901\/jeab.2005.22-04","article-title":"Marijuana effects on human forgetting functions","volume":"83","author":"Lane","year":"2005","journal-title":"J Exp Anal Behav"},{"issue":"5","key":"10.1016\/j.pharmthera.2014.11.009_bb0735","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.addbeh.2006.07.007","article-title":"Response perseveration and adaptation in heavy marijuana-smoking adolescents","volume":"32","author":"Lane","year":"2007","journal-title":"Addict Behav"},{"issue":"6","key":"10.1016\/j.pharmthera.2014.11.009_bb0740","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1001\/archgenpsychiatry.2011.5","article-title":"Cannabis use and earlier onset of psychosis: a systematic meta-analysis","volume":"68","author":"Large","year":"2011","journal-title":"Arch Gen Psychiatry"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0745","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.nbd.2004.11.009","article-title":"Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's disease","volume":"19","author":"Lastres-Becker","year":"2005","journal-title":"Neurobiol Dis"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb0750","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0006-8993(00)02739-6","article-title":"Changes in hippocampal morphology following chronic treatment with the synthetic cannabinoid WIN 55,212-2","volume":"877","author":"Lawston","year":"2000","journal-title":"Brain Res"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb0755","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s11065-011-9163-0","article-title":"Imaging the impact of prenatal alcohol exposure on the structure of the developing human brain","volume":"21","author":"Lebel","year":"2011","journal-title":"Neuropsychol Rev"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb0760","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0892-0362(98)00042-7","article-title":"Prenatal substance exposure: effects on attention and impulsivity of 6-year-olds","volume":"21","author":"Leech","year":"1999","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb0765","article-title":"The association between cannabis use and depression: a systematic review and meta-analysis of longitudinal studies","volume":"1\u201314","author":"Lev-Ran","year":"2013","journal-title":"Psychol Med"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0770","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/BF02246292","article-title":"Systemic or intrahippocampal cannabinoid administration impairs spatial memory in rats","volume":"119","author":"Lichtman","year":"1995","journal-title":"Psychopharmacology (Berl)"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb0775","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1054\/plef.2001.0351","article-title":"Endocannabinoids in cognition and dependence","volume":"66","author":"Lichtman","year":"2002","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb0780","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2013.00053","article-title":"Dare to delay? The impacts of adolescent alcohol and marijuana use onset on cognition, brain structure, and function","volume":"4","author":"Lisdahl","year":"2013","journal-title":"Front Psychiatry"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb0785","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/j.1369-1600.2011.00318.x","article-title":"Sex\u2010dependent effects of maternal deprivation and adolescent cannabinoid treatment on adult rat behaviour","volume":"16","author":"Llorente\u2010Berzal","year":"2011","journal-title":"Addict Biol"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0790","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.bbr.2011.02.001","article-title":"Altered prefrontal and insular cortical thickness in adolescent marijuana users","volume":"220","author":"Lopez-Larson","year":"2011","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb0795","series-title":"The Impact of Regular Cannabis Use on the Human Brain: A Review of Structural Neuroimaging Studies Biological Research on Addiction: Comprehensive Addictive Behaviors and Disorders","first-page":"711","author":"Lorenzetti","year":"2013"},{"issue":"13","key":"10.1016\/j.pharmthera.2014.11.009_bb8000","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.2174\/13816128113199990435","article-title":"The association between regular cannabis exposure and alterations of human brain morphology: an updated review of the literature","volume":"20","author":"Lorenzetti","year":"2014","journal-title":"Curr Pharm Des"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0800","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.neuroscience.2004.09.042","article-title":"Glutamate and GABA receptor signalling in the developing brain","volume":"130","author":"Lujan","year":"2005","journal-title":"Neuroscience"},{"issue":"5","key":"10.1016\/j.pharmthera.2014.11.009_bb0805","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0892-0362(01)00165-9","article-title":"Frontal lobe dysfunction in long-term cannabis users","volume":"23","author":"Lundqvist","year":"2001","journal-title":"Neurotoxicol Teratol"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0810","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1476-5381.2010.00721.x","article-title":"Adolescent cannabis use and psychosis: epidemiology and neurodevelopmental models","volume":"160","author":"Malone","year":"2010","journal-title":"Br J Pharmacol"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb0815","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.pbb.2009.04.010","article-title":"Cannabidiol reverses the reduction in social interaction produced by low dose \u0394-9-tetrahydrocannabinol in rats","volume":"93","author":"Malone","year":"2009","journal-title":"Pharmacol Biochem Behav"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0820","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bbr.2005.07.009","article-title":"The effect of \u0394-9-tetrahydrocannabinol on sensorimotor gating in socially isolated rats","volume":"166","author":"Malone","year":"2006","journal-title":"Behav Brain Res"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb0830","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.nbd.2009.01.014","article-title":"Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis","volume":"34","author":"Marchalant","year":"2009","journal-title":"Neurobiol Dis"},{"issue":"12","key":"10.1016\/j.pharmthera.2014.11.009_bb0825","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/mp.2009.62","article-title":"Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain","volume":"14","author":"Marchalant","year":"2009","journal-title":"Mol Psychiatry"},{"issue":"12","key":"10.1016\/j.pharmthera.2014.11.009_bb0835","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1016\/j.neurobiolaging.2007.04.028","article-title":"Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats","volume":"29","author":"Marchalant","year":"2008","journal-title":"Neurobiol Aging"},{"issue":"5642","key":"10.1016\/j.pharmthera.2014.11.009_bb8005","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.1088208","article-title":"CB1 cannabinoid receptors and on-demand defense against excitotoxicity","volume":"302","author":"Marsicano","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb0840","series-title":"Behavioral Neurobiology of the Endocannabinoid System","first-page":"201","article-title":"Roles of the endocannabinoid system in learning and memory","author":"Marsicano","year":"2009"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0845","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1017\/S0033291709990729","article-title":"Neuroimaging in cannabis use: a systematic review of the literature","volume":"40","author":"Martin-Santos","year":"2010","journal-title":"Psychol Med"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb0850","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1360-0443.1986.tb00369.x","article-title":"Regional cerebral blood flow in marijuana smokers","volume":"81","author":"Mathew","year":"1986","journal-title":"Br J Addict"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb0855","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1600-0447.1989.tb08579.x","article-title":"Acute changes in cerebral blood flow associated with marijuana smoking","volume":"79","author":"Mathew","year":"1989","journal-title":"Acta Psychiatr Scand"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0860","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.drugalcdep.2004.06.011","article-title":"Altered brain tissue composition in heavy marijuana users","volume":"77","author":"Matochik","year":"2005","journal-title":"Drug Alcohol Depend"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0865","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0006-8993(03)03376-6","article-title":"Neuroprotective and brain edema-reducing efficacy of the novel cannabinoid receptor agonist BAY 38-7271","volume":"989","author":"Mauler","year":"2003","journal-title":"Brain Res"},{"issue":"7","key":"10.1016\/j.pharmthera.2014.11.009_bb0870","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1038\/sj.npp.1300176","article-title":"Effects of THC on behavioral measures of impulsivity in humans","volume":"28","author":"McDonald","year":"2003","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0875","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.drugpo.2009.09.001","article-title":"Assessing evidence for a causal link between cannabis and psychosis: a review of cohort studies","volume":"21","author":"McLaren","year":"2010","journal-title":"Int J Drug Policy"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0880","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.bbr.2011.05.031","article-title":"Gender effects on amygdala morphometry in adolescent marijuana users","volume":"224","author":"McQueeny","year":"2011","journal-title":"Behav Brain Res"},{"issue":"05","key":"10.1016\/j.pharmthera.2014.11.009_bb0885","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1017\/S1355617707071032","article-title":"Neuropsychological functioning in adolescent marijuana users: subtle deficits detectable after a month of abstinence","volume":"13","author":"Medina","year":"2007","journal-title":"J Int Neuropsychol Soc"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb0890","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1369-1600.2009.00166.x","article-title":"Prefrontal cortex morphometry in abstinent adolescent marijuana users: subtle gender effects","volume":"14","author":"Medina","year":"2009","journal-title":"Addict Biol"},{"issue":"6","key":"10.1016\/j.pharmthera.2014.11.009_bb0895","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/j.1469-7610.2007.01728.x","article-title":"Depressive symptoms in adolescents: associations with white matter volume and marijuana use","volume":"48","author":"Medina","year":"2007","journal-title":"J Child Psychol Psychiatry"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0900","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ntt.2006.10.010","article-title":"Effects of alcohol and combined marijuana and alcohol use during adolescence on hippocampal volume and asymmetry","volume":"29","author":"Medina","year":"2007","journal-title":"Neurotoxicol Teratol"},{"issue":"40","key":"10.1016\/j.pharmthera.2014.11.009_bb0905","doi-asserted-by":"crossref","first-page":"E2657","DOI":"10.1073\/pnas.1206820109","article-title":"Persistent cannabis users show neuropsychological decline from childhood to midlife","volume":"109","author":"Meier","year":"2012","journal-title":"Proc Natl Acad Sci"},{"issue":"8","key":"10.1016\/j.pharmthera.2014.11.009_bb0910","doi-asserted-by":"crossref","first-page":"4915","DOI":"10.1073\/pnas.0537849100","article-title":"Prenatal exposure to a cannabinoid agonist produces memory deficits linked to dysfunction in hippocampal long-term potentiation and glutamate release","volume":"100","author":"Mereu","year":"2003","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0915","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1300\/J029v03n01_05","article-title":"Neuropsychological effects of chronic cannabis use on the memory and intelligence of adolescents","volume":"3","author":"Millsaps","year":"1994","journal-title":"J Child Adolesc Subst Abuse"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb0920","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.pbb.2013.09.015","article-title":"Adolescent cannabinoid treatment negatively affects reproductive behavior in female rats","volume":"112","author":"Minney","year":"2013","journal-title":"Pharmacol Biochem Behav"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb0925","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0304-3940(95)12189-7","article-title":"Effect of repeated administration of \u03949-tetrahydrocannabinol on delayed matching-to-sample performance in rats","volume":"201","author":"Miyamoto","year":"1995","journal-title":"Neurosci Lett"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb0935","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0014-2999(96)00753-4","article-title":"Effect of maternal \u03949-tetrahydrocannabinol on developing serotonergic system","volume":"316","author":"Molina-Holgado","year":"1996","journal-title":"Eur J Pharmacol"},{"issue":"22","key":"10.1016\/j.pharmthera.2014.11.009_bb0930","doi-asserted-by":"crossref","first-page":"9742","DOI":"10.1523\/JNEUROSCI.22-22-09742.2002","article-title":"Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and phosphatidylinositol-3 kinase\/Akt signaling","volume":"22","author":"Molina-Holgado","year":"2002","journal-title":"J Neurosci"},{"issue":"5","key":"10.1016\/j.pharmthera.2014.11.009_bb0940","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.phrs.2010.01.002","article-title":"Investigation of CNR1 and FAAH endocannabinoid gene polymorphisms in bipolar disorder and major depression","volume":"61","author":"Monteleone","year":"2010","journal-title":"Pharmacol Res"},{"issue":"9584","key":"10.1016\/j.pharmthera.2014.11.009_bb0945","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0140-6736(07)61162-3","article-title":"Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review","volume":"370","author":"Moore","year":"2007","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.pharmthera.2014.11.009_bb0950","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.pnpbp.2006.06.004","article-title":"Anxiolytic-like effect of cannabidiol in the rat Vogel conflict test","volume":"30","author":"Moreira","year":"2006","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb0955","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ejphar.2005.02.040","article-title":"Cannabidiol inhibits the hyperlocomotion induced by psychotomimetic drugs in mice","volume":"512","author":"Moreira","year":"2005","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb0960","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.nlm.2013.12.010","article-title":"The endocannabinoid system: an emotional buffer in the modulation of memory function","volume":"112","author":"Morena","year":"2014","journal-title":"Neurobiol Learn Mem"},{"issue":"10","key":"10.1016\/j.pharmthera.2014.11.009_bb0965","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1017\/S0033291709005522","article-title":"The acute effects of synthetic intravenous \u03949-tetrahydrocannabinol on psychosis, mood and cognitive functioning","volume":"39","author":"Morrison","year":"2009","journal-title":"Psychol Med"},{"issue":"8","key":"10.1016\/j.pharmthera.2014.11.009_bb0970","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1523\/JNEUROSCI.19-08-02987.1999","article-title":"Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures","volume":"19","author":"Nagayama","year":"1999","journal-title":"J Neurosci"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb0975","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0376-8716(91)90072-7","article-title":"Reversible effects of acute and long-term administration of \u0394-9-tetrahydrocannabinol (THC) on memory in the rat","volume":"28","author":"Nakamura","year":"1991","journal-title":"Drug Alcohol Depend"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb0980","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1007\/s00221-006-0503-x","article-title":"Increased cannabinoid receptor density in the posterior cingulate cortex in schizophrenia","volume":"172","author":"Newell","year":"2006","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb0985","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2013.00130","article-title":"Does cannabidiol protect against adverse psychological effects of THC?","volume":"4","author":"Niesink","year":"2013","journal-title":"Front Psychiatry"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0990","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.ntt.2005.02.001","article-title":"Prenatal drug exposure and selective attention in preschoolers","volume":"27","author":"Noland","year":"2005","journal-title":"Neurotoxicol Teratol"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb1005","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1177\/0269881104047277","article-title":"Chronic cannabinoid exposure produces lasting memory impairment and increased anxiety in adolescent but not adult rats","volume":"18","author":"O'Shea","year":"2004","journal-title":"J Psychopharmacol"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb0995","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/hup.832","article-title":"Effects of smoking marijuana on focal attention and brain blood flow","volume":"22","author":"O'Leary","year":"2007","journal-title":"Hum Psychopharmacol Clin Exp"},{"issue":"5","key":"10.1016\/j.pharmthera.2014.11.009_bb1000","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1177\/0269881106065188","article-title":"Repeated cannabinoid exposure during perinatal, adolescent or early adult ages produces similar longlasting deficits in object recognition and reduced social interaction in rats","volume":"20","author":"O'Shea","year":"2006","journal-title":"J Psychopharmacol"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb1010","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.nbd.2005.11.004","article-title":"The endocannabinoid 2-AG protects the blood\u2013brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines","volume":"22","author":"Panikashvili","year":"2006","journal-title":"Neurobiol Dis"},{"issue":"6855","key":"10.1016\/j.pharmthera.2014.11.009_bb1015","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/35097089","article-title":"An endogenous cannabinoid (2-AG) is neuroprotective after brain injury","volume":"413","author":"Panikashvili","year":"2001","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb1020","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.expneurol.2010.03.018","article-title":"The endocannabinoid system and psychiatric disorders","volume":"224","author":"Parolaro","year":"2010","journal-title":"Exp Neurol"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb1025","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.tics.2004.12.008","article-title":"Mapping brain maturation and cognitive development during adolescence","volume":"9","author":"Paus","year":"2005","journal-title":"Trends Cogn Sci"},{"issue":"10","key":"10.1016\/j.pharmthera.2014.11.009_bb1030","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1111\/ejn.12341","article-title":"Neuroprotection and reduction of glial reaction by cannabidiol treatment after sciatic nerve transection in neonatal rats","volume":"38","author":"Perez","year":"2013","journal-title":"Eur J Neurosci"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb1035","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.biopsych.2004.05.006","article-title":"Adolescent exposure to cannabinoids induces long-lasting changes in the response to drugs of abuse of rat midbrain dopamine neurons","volume":"56","author":"Pistis","year":"2004","journal-title":"Biol Psychiatry"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb1040","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0376-8716(02)00334-4","article-title":"Early-onset cannabis use and cognitive deficits: what is the nature of the association?","volume":"69","author":"Pope","year":"2003","journal-title":"Drug Alcohol Depend"},{"issue":"10","key":"10.1016\/j.pharmthera.2014.11.009_bb1045","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1001\/archpsyc.58.10.909","article-title":"Neuropsychological performance in long-term cannabis users","volume":"58","author":"Pope","year":"2001","journal-title":"Arch Gen Psychiatry"},{"issue":"5","key":"10.1016\/j.pharmthera.2014.11.009_bb1050","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1080\/07448481.2012.663840","article-title":"Tobacco, marijuana, and alcohol use in university students: a cluster analysis","volume":"60","author":"Primack","year":"2012","journal-title":"J Am Coll Health"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb1055","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1176\/jnp.2006.18.3.318","article-title":"Brain neuroimaging in cannabis use: a review","volume":"18","author":"Quickfall","year":"2006","journal-title":"J Neuropsychiatry Clin Neurosci"},{"issue":"5","key":"10.1016\/j.pharmthera.2014.11.009_bb1060","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/sj.npp.1301475","article-title":"Adolescent rats find repeated \u03949-THC less aversive than adult rats but display greater residual cognitive deficits and changes in hippocampal protein expression following exposure","volume":"33","author":"Quinn","year":"2008","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb1065","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1177\/0269881108092393","article-title":"Neurocognitive performance during acute THC intoxication in heavy and occasional cannabis users","volume":"23","author":"Ramaekers","year":"2009","journal-title":"J Psychopharmacol"},{"issue":"10","key":"10.1016\/j.pharmthera.2014.11.009_bb1070","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1038\/sj.npp.1301068","article-title":"High-potency marijuana impairs executive function and inhibitory motor control","volume":"31","author":"Ramaekers","year":"2006","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb1075","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00213-006-0508-y","article-title":"The acute effects of cannabinoids on memory in humans: a review","volume":"188","author":"Ranganathan","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb1080","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.neuropharm.2010.09.003","article-title":"Chronic URB597 treatment at adulthood reverted most depressive-like symptoms induced by adolescent exposure to THC in female rats","volume":"60","author":"Realini","year":"2011","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb1085","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s00213-012-2865-z","article-title":"Long-term cognitive impairments induced by chronic cannabinoid exposure during adolescence in rats: a strain comparison","volume":"225","author":"Renard","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb1090","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1476-5381.2008.00046.x","article-title":"5\u2010HT1A receptors are involved in the cannabidiol\u2010induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats","volume":"156","author":"Resstel","year":"2009","journal-title":"Br J Pharmacol"},{"issue":"5","key":"10.1016\/j.pharmthera.2014.11.009_bb1095","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1601-5215.2011.00579.x","article-title":"Administration of cannabidiol and imipramine induces antidepressant\u2010like effects in the forced swimming test and increases brain\u2010derived neurotrophic factor levels in the rat amygdala","volume":"23","author":"Reus","year":"2011","journal-title":"Acta Neuropsychiatr"},{"issue":"6","key":"10.1016\/j.pharmthera.2014.11.009_bb1105","doi-asserted-by":"crossref","first-page":"796","DOI":"10.3923\/ijp.2010.796.807","article-title":"Cannabis use and mental health: a review of recent epidemiological research","volume":"6","author":"Richardson","year":"2010","journal-title":"Int J Pharmacol"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb1100","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0892-0362(02)00193-9","article-title":"Prenatal alcohol and marijuana exposure: effects on neuropsychological outcomes at 10years","volume":"24","author":"Richardson","year":"2002","journal-title":"Neurotoxicol Teratol"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb1110","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1542\/peds.2007-1399","article-title":"Volumetric MRI study of brain in children with intrauterine exposure to cocaine, alcohol, tobacco, and marijuana","volume":"121","author":"Rivkin","year":"2008","journal-title":"Pediatrics"},{"issue":"11","key":"10.1016\/j.pharmthera.2014.11.009_bb1120","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1073\/pnas.1215678110","article-title":"Correlations between cannabis use and IQ change in the Dunedin cohort are consistent with confounding from socioeconomic status","volume":"110","author":"Rogeberg","year":"2013","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb1115","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/(SICI)1098-2396(199707)26:3<317::AID-SYN12>3.0.CO;2-S","article-title":"Atypical location of cannabinoid receptors in white matter areas during rat brain development","volume":"26","author":"Romero","year":"1997","journal-title":"Synapse"},{"issue":"11","key":"10.1016\/j.pharmthera.2014.11.009_bb1125","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1038\/sj.npp.1301664","article-title":"Chronic \u03949-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates","volume":"33","author":"Rubino","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb1130","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.pnpbp.2013.07.020","article-title":"Cannabis abuse in adolescence and the risk of psychosis: a brief review of the preclinical evidence","volume":"52","author":"Rubino","year":"2013","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb1135","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1177\/0269881111405362","article-title":"Adolescent exposure to cannabis as a risk factor for psychiatric disorders","volume":"26","author":"Rubino","year":"2012","journal-title":"J Psychopharmacol"},{"issue":"7","key":"10.1016\/j.pharmthera.2014.11.009_bb1140","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1111\/j.1476-5381.2011.01280.x","article-title":"The dual neuroprotective\u2013neurotoxic profile of cannabinoid drugs","volume":"163","author":"Sarne","year":"2011","journal-title":"Br J Pharmacol"},{"issue":"6","key":"10.1016\/j.pharmthera.2014.11.009_bb1145","doi-asserted-by":"crossref","first-page":"677","DOI":"10.2174\/156800705774933005","article-title":"Cannabinoids: between neuroprotection and neurotoxicity","volume":"4","author":"Sarne","year":"2005","journal-title":"Curr Drug Targets CNS Neurol Disord"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb1150","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/0091-3057(91)90380-K","article-title":"Neurotoxicology of cannabis and THC: a review of chronic exposure studies in animals","volume":"40","author":"Scallet","year":"1991","journal-title":"Pharmacol Biochem Behav"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb1155","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0006-8993(87)91576-9","article-title":"Morphometric studies of the rat hippocampus following chronic delta-9-tetrahydrocannabinol (THC)","volume":"436","author":"Scallet","year":"1987","journal-title":"Brain Res"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb1160","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.euroneuro.2006.03.009","article-title":"The effect of chronic peripubertal cannabinoid treatment on deficient object recognition memory in rats after neonatal mPFC lesion","volume":"17","author":"Schneider","year":"2007","journal-title":"Eur Neuropsychopharmacol"},{"issue":"3\u20134","key":"10.1016\/j.pharmthera.2014.11.009_bb1165","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1369-1600.2008.00117.x","article-title":"Preclinical study: acute and chronic cannabinoid treatment differentially affects recognition memory and social behavior in pubertal and adult rats","volume":"13","author":"Schneider","year":"2008","journal-title":"Addict Biol"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb1170","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s00213-006-0676-9","article-title":"Differential anxiogenic, aversive, and locomotor effects of THC in adolescent and adult rats","volume":"191","author":"Schramm-Sapyta","year":"2007","journal-title":"Psychopharmacology (Berl)"},{"issue":"5","key":"10.1016\/j.pharmthera.2014.11.009_bb1175","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1037\/a0029117","article-title":"Residual effects of cannabis use on neurocognitive performance after prolonged abstinence: a meta-analysis","volume":"20","author":"Schreiner","year":"2012","journal-title":"Exp Clin Psychopharmacol"},{"issue":"10","key":"10.1016\/j.pharmthera.2014.11.009_bb1180","first-page":"1214","article-title":"Short-term memory impairment in cannabis-dependent adolescents","volume":"143","author":"Schwartz","year":"1989","journal-title":"Am J Dis Child"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb1185","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0166-2236(99)01499-X","article-title":"Dendritic spine formation and pruning: common cellular mechanisms?","volume":"23","author":"Segal","year":"2000","journal-title":"Trends Neurosci"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb1190","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00213-008-1075-1","article-title":"Cerebral glucose metabolism and D2\/D3 receptor availability in young adults with cannabis dependence measured with positron emission tomography","volume":"197","author":"Sevy","year":"2008","journal-title":"Psychopharmacology (Berl)"},{"issue":"8","key":"10.1016\/j.pharmthera.2014.11.009_bb1195","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.neuropharm.2011.07.002","article-title":"Chronic administration of THC prevents the behavioral effects of intermittent adolescent MDMA administration and attenuates MDMA-induced hyperthermia and neurotoxicity in rats","volume":"61","author":"Shen","year":"2011","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb1200","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/glia.20108","article-title":"Synthetic cannabinoid WIN55, 212-2 inhibits generation of inflammatory mediators by IL\u20101\u03b2\u2010stimulated human astrocytes","volume":"49","author":"Sheng","year":"2005","journal-title":"Glia"},{"issue":"8","key":"10.1016\/j.pharmthera.2014.11.009_bb1205","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.euroneuro.2008.04.016","article-title":"Differences in regional blood volume during a 28-day period of abstinence in chronic cannabis smokers","volume":"18","author":"Sneider","year":"2008","journal-title":"Eur Neuropsychopharmacol"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb1210","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2174\/1874473710801010081","article-title":"The chronic effects of cannabis on memory in humans: a review","volume":"1","author":"Solowij","year":"2008","journal-title":"Curr Drug Abuse Rev"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb1215","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00213-011-2203-x","article-title":"Verbal learning and memory in adolescent cannabis users, alcohol users and non-users","volume":"216","author":"Solowij","year":"2011","journal-title":"Psychopharmacology (Berl)"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb1220","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00213-011-2486-y","article-title":"Reflection impulsivity in adolescent cannabis users: a comparison with alcohol-using and non-substance-using adolescents","volume":"219","author":"Solowij","year":"2012","journal-title":"Psychopharmacology"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb1225","first-page":"30","article-title":"Cannabis and cognitive dysfunction: parallels with endophenotypes of schizophrenia?","volume":"32","author":"Solowij","year":"2007","journal-title":"J Psychiatry Neurosci"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb1230","series-title":"Marijuana and madness","first-page":"91","article-title":"Cannabis and cognition: short and long-term effects","author":"Solowij","year":"2012"},{"issue":"9","key":"10.1016\/j.pharmthera.2014.11.009_bb1235","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1001\/jama.287.9.1123","article-title":"Cognitive functioning of long-term heavy cannabis users seeking treatment","volume":"287","author":"Solowij","year":"2002","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb1240","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.schres.2012.10.040","article-title":"Alteration to hippocampal shape in cannabis users with and without schizophrenia","volume":"143","author":"Solowij","year":"2013","journal-title":"Schizophr Res"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb1245","series-title":"Does Cannabis Cause Lasting Brain Damage?","author":"Solowij","year":"2012"},{"issue":"11","key":"10.1016\/j.pharmthera.2014.11.009_bb1250","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1017\/S003329171100050X","article-title":"Cerebellar white-matter changes in cannabis users with and without schizophrenia","volume":"41","author":"Solowij","year":"2011","journal-title":"Psychol Med"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb1255","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0149-7634(00)00014-2","article-title":"The adolescent brain and age-related behavioral manifestations","volume":"24","author":"Spear","year":"2000","journal-title":"Neurosci Biobehav Rev"},{"issue":"10","key":"10.1016\/j.pharmthera.2014.11.009_bb1260","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1111\/j.1360-0443.2004.00806.x","article-title":"Early adolescent cannabis exposure and positive and negative dimensions of psychosis","volume":"99","author":"Stefanis","year":"2004","journal-title":"Addiction"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb1265","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.tics.2004.12.005","article-title":"Cognitive and affective development in adolescence","volume":"9","author":"Steinberg","year":"2005","journal-title":"Trends Cogn Sci"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb1270","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF00431932","article-title":"Learning impairment in the radial-arm maze following prolonged cannabis treatment in rats","volume":"77","author":"Stiglick","year":"1982","journal-title":"Psychopharmacology (Berl)"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb1275","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/BF00431933","article-title":"Residual effects of prolonged cannabis administration on exploration and DRL performance in rats","volume":"77","author":"Stiglick","year":"1982","journal-title":"Psychopharmacology (Berl)"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb1280","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/BF00429660","article-title":"Residual effects of chronic cannabis treatment on behavior in mature rats","volume":"85","author":"Stiglick","year":"1985","journal-title":"Psychopharmacology (Berl)"},{"issue":"7","key":"10.1016\/j.pharmthera.2014.11.009_bb1285","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/hipo.20537","article-title":"Early maternal deprivation induces gender\u2010dependent changes on the expression of hippocampal CB1 and CB2 cannabinoid receptors of neonatal rats","volume":"19","author":"Su\u00e1rez","year":"2009","journal-title":"Hippocampus"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb1290","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.brainres.2010.06.042","article-title":"Early maternal deprivation induces changes on the expression of 2-AG biosynthesis and degradation enzymes in neonatal rat hippocampus","volume":"1349","author":"Su\u00e1rez","year":"2010","journal-title":"Brain Res"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb1295","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1101\/lm.7.3.132","article-title":"Cellular and molecular mechanisms underlying learning and memory impairments produced by cannabinoids","volume":"7","author":"Sullivan","year":"2000","journal-title":"Learn Mem"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb1300","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.pbb.2008.05.010","article-title":"Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures\u2014a short review","volume":"90","author":"Sv\u00ed\u017eensk\u00e1","year":"2008","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb1305","series-title":"Cannabinoids","first-page":"327","article-title":"Effects of cannabinoids on neurotransmission","author":"Szabo","year":"2005"},{"issue":"7","key":"10.1016\/j.pharmthera.2014.11.009_bb1310","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1017\/S1355617702870011","article-title":"Substance use and withdrawal: neuropsychological functioning over 8years in youth","volume":"8","author":"Tapert","year":"2002","journal-title":"J Int Neuropsychol Soc"},{"issue":"1\u20132","key":"10.1016\/j.pharmthera.2014.11.009_bb1315","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jad.2010.09.013","article-title":"White matter abnormalities in major depression: evidence from post-mortem, neuroimaging and genetic studies","volume":"132","author":"Tham","year":"2011","journal-title":"J Affect Disord"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb1320","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neulet.2006.10.033","article-title":"A single low dose of tetrahydrocannabinol induces long-term cognitive deficits","volume":"411","author":"Tselnicker","year":"2007","journal-title":"Neurosci Lett"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb1325","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0165-1781(86)90037-5","article-title":"Regional cerebral blood flow in long-term heavy cannabis use","volume":"17","author":"Tunving","year":"1986","journal-title":"Psychiatry Res"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb1330","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1080\/10550490590899862","article-title":"Lack of hippocampal volume change in long-term heavy cannabis users","volume":"14","author":"Tzilos","year":"2005","journal-title":"Am J Addict"},{"issue":"22","key":"10.1016\/j.pharmthera.2014.11.009_bb1335","doi-asserted-by":"crossref","first-page":"8765","DOI":"10.1523\/JNEUROSCI.21-22-08765.2001","article-title":"Exogenous anandamide protects rat brain against acute neuronal injury in vivo","volume":"21","author":"Van der Stelt","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb1340","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1146\/annurev-clinpsy-032813-153631","article-title":"Epidemiological, neurobiological, and genetic clues to the mechanisms linking cannabis use to risk for nonaffective psychosis","volume":"10","author":"Van Winkel","year":"2014","journal-title":"Annu Rev Clin Psychol"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb1345","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.drugalcdep.2007.11.017","article-title":"Divergent effects of cannabidiol on the discriminative stimulus and place conditioning effects of \u0394-9-tetrahydrocannabinol","volume":"94","author":"Vann","year":"2008","journal-title":"Drug Alcohol Depend"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb1350","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/sj.npp.1300316","article-title":"Repeated, intermittent \u03949-tetrahydrocannabinol administration to rats impairs acquisition and performance of a test of visuospatial divided attention","volume":"29","author":"Verrico","year":"2004","journal-title":"Neuropsychopharmacology"},{"issue":"5","key":"10.1016\/j.pharmthera.2014.11.009_bb1355","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.biopsych.2004.11.033","article-title":"Elevated levels of endocannabinoids and CB1 receptor-mediated G-protein signaling in the prefrontal cortex of alcoholic suicide victims","volume":"57","author":"Vinod","year":"2005","journal-title":"Biol Psychiatry"},{"issue":"9","key":"10.1016\/j.pharmthera.2014.11.009_bb1360","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jpsychires.2009.11.013","article-title":"Selective alterations of the CB1 receptors and the fatty acid amide hydrolase in the ventral striatum of alcoholics and suicides","volume":"44","author":"Vinod","year":"2010","journal-title":"J Psychiatr Res"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb1365","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1177\/0269881111408956","article-title":"The endocannbinoid system in critical neurodevelopmental periods: sex differences and neuropsychiatric implications","volume":"26","author":"Viveros","year":"2012","journal-title":"J Psychopharmacol"},{"issue":"23","key":"10.1016\/j.pharmthera.2014.11.009_bb1370","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1056\/NEJMra1402309","article-title":"Adverse health effects of marijuana use","volume":"370","author":"Volkow","year":"2014","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb1375","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0925-4927(96)02817-X","article-title":"Brain glucose metabolism in chronic marijuana users at baseline and during marijuana intoxication","volume":"67","author":"Volkow","year":"1996","journal-title":"Psychiatry Res Neuroimaging"},{"issue":"5","key":"10.1016\/j.pharmthera.2014.11.009_bb1380","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/sj.bjp.0705667","article-title":"Cannabinoids and neuroinflammation","volume":"141","author":"Walter","year":"2004","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb1385","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.socscimed.2014.01.023","article-title":"The impact of youth, family, peer and neighborhood risk factors on developmental trajectories of risk involvement from early through middle adolescence","volume":"106","author":"Wang","year":"2014","journal-title":"Soc Sci Med"},{"issue":"5","key":"10.1016\/j.pharmthera.2014.11.009_bb1390","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1542\/peds.2006-0003","article-title":"Diffusion tensor imaging of frontal white matter and executive functioning in cocaine-exposed children","volume":"118","author":"Warner","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.pharmthera.2014.11.009_bb1395","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.brainres.2008.11.081","article-title":"Behavioural disturbances and altered Fos protein expression in adult rats after chronic pubertal cannabinoid treatment","volume":"1253","author":"Wegener","year":"2009","journal-title":"Brain Res"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb1400","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00213-002-1001-x","article-title":"Metabolic mapping of the time-dependent effects of \u03949-tetrahydrocannabinol administration in the rat","volume":"161","author":"Whitlow","year":"2002","journal-title":"Psychopharmacology (Berl)"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb1410","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0165-1781(94)90031-0","article-title":"Effects of marijuana on performance of a computerized cognitive-neuromotor test battery","volume":"51","author":"Wilson","year":"1994","journal-title":"Psychiatry Res"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb1405","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1300\/J069v19n01_01","article-title":"Brain morphological changes and early marijuana use: a magnetic resonance and positron emission tomography study","volume":"19","author":"Wilson","year":"2000","journal-title":"J Addict Dis"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb1415","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.neuroimage.2010.04.034","article-title":"Quantification of cerebral cannabinoid receptors subtype 1 (CB1) in healthy subjects and schizophrenia by the novel PET radioligand [11C] OMAR","volume":"52","author":"Wong","year":"2010","journal-title":"Neuroimage"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb1420","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2217\/fnl.11.27","article-title":"Lasting impacts of prenatal cannabis exposure and the role of endogenous cannabinoids in the developing brain","volume":"6","author":"Wu","year":"2011","journal-title":"Future Neurol"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb1425","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.neuroscience.2007.08.037","article-title":"Post-training CB1 cannabinoid receptor agonist activation disrupts long-term consolidation of spatial memories in the hippocampus","volume":"151","author":"Yim","year":"2008","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb1430","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/schbul\/sbq079","article-title":"The impact of cannabis use on cognitive functioning in patients with schizophrenia: a meta-analysis of existing findings and new data in a first-episode sample","volume":"38","author":"Y\u00fccel","year":"2012","journal-title":"Schizophr Bull"},{"issue":"5","key":"10.1016\/j.pharmthera.2014.11.009_bb1435","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1601-5215.2006.00154.x","article-title":"Structural brain correlates of alcohol and cannabis use in recreational users","volume":"18","author":"Y\u00fccel","year":"2006","journal-title":"Acta Neuropsychiatr"},{"issue":"6","key":"10.1016\/j.pharmthera.2014.11.009_bb1440","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1001\/archpsyc.65.6.694","article-title":"Regional brain abnormalities associated with long-term heavy cannabis use","volume":"65","author":"Y\u00fccel","year":"2008","journal-title":"Arch Gen Psychiatry"},{"issue":"6","key":"10.1016\/j.pharmthera.2014.11.009_bb1445","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1503\/jpn.090177","article-title":"White-matter abnormalities in adolescents with long-term inhalant and cannabis use: a diffusion magnetic resonance imaging study","volume":"35","author":"Y\u00fccel","year":"2010","journal-title":"J Psychiatry Neurosci"},{"issue":"7","key":"10.1016\/j.pharmthera.2014.11.009_bb1450","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1093\/brain\/aws136","article-title":"Effect of long-term cannabis use on axonal fibre connectivity","volume":"135","author":"Zalesky","year":"2012","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb1455","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1476-5381.2009.00521.x","article-title":"Antidepressant\u2010like effects of cannabidiol in mice: possible involvement of 5\u2010HT1A receptors","volume":"159","author":"Zanelati","year":"2010","journal-title":"Br J Pharmacol"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb1460","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.pnpbp.2003.11.005","article-title":"Selective antagonist [3H] SR141716A binding to cannabinoid CB1 receptors is increased in the anterior cingulate cortex in schizophrenia","volume":"28","author":"Zavitsanou","year":"2004","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"1 Suppl.","key":"10.1016\/j.pharmthera.2014.11.009_bb1465","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1177\/026988119300700112","article-title":"Effects of ipsapirone and cannabidiol on human experimental anxiety","volume":"7","author":"Zuardi","year":"1993","journal-title":"J Psychopharmacol"},{"issue":"4","key":"10.1016\/j.pharmthera.2014.11.009_bb1470","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1590\/S0100-879X2006000400001","article-title":"Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug","volume":"39","author":"Zuardi","year":"2006","journal-title":"Braz J Med Biol Res"},{"issue":"2","key":"10.1016\/j.pharmthera.2014.11.009_bb1475","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/BF02244189","article-title":"Effects of cannabidiol in animal models predictive of antipsychotic activity","volume":"104","author":"Zuardi","year":"1991","journal-title":"Psychopharmacology (Berl)"},{"issue":"3","key":"10.1016\/j.pharmthera.2014.11.009_bb1480","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/BF00432554","article-title":"Action of cannabidiol on the anxiety and other effects produced by \u03949-THC in normal subjects","volume":"76","author":"Zuardi","year":"1982","journal-title":"Psychopharmacology (Berl)"},{"issue":"1","key":"10.1016\/j.pharmthera.2014.11.009_bb1485","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1365-2125.2008.03329.x","article-title":"Biomarkers for the effects of cannabis and THC in healthy volunteers","volume":"67","author":"Zuurman","year":"2009","journal-title":"Br J Clin Pharmacol"}],"container-title":["Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725814002095?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725814002095?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T16:02:03Z","timestamp":1747152123000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725814002095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":301,"alternative-id":["S0163725814002095"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2014.11.009","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cannabis and adolescent brain development","name":"articletitle","label":"Article Title"},{"value":"Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmthera.2014.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}