{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:36:48Z","timestamp":1790822208646,"version":"4.1.0"},"reference-count":567,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,12,28]],"date-time":"2014-12-28T00:00:00Z","timestamp":1419724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["SFB F4410"],"award-info":[{"award-number":["SFB F4410"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P25375-B24"],"award-info":[{"award-number":["P25375-B24"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.pharmthera.2014.12.004","type":"journal-article","created":{"date-parts":[[2014,12,27]],"date-time":"2014-12-27T11:33:33Z","timestamp":1419680013000},"page":"150-190","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":371,"special_numbering":"C","title":["Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders"],"prefix":"10.1016","volume":"149","author":[{"given":"N.","family":"Singewald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Schmuckermair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Whittle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.J.","family":"Ressler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharmthera.2014.12.004_bb0005","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0165-3806(00)00054-7","article-title":"Neurotrophic effect of basic fibroblast growth factor is mediated by the p42\/p44 mitogen-activated protein kinase cascade in cultured rat cortical neurons","volume":"122","author":"Abe","year":"2000","journal-title":"Brain Res Dev Brain Res"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0010","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1101\/lm.024752.111","article-title":"Methylphenidate enhances extinction of contextual fear","volume":"19","author":"Abraham","year":"2012","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0015","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.nlm.2013.11.007","article-title":"Dopamine and extinction: a convergence of theory with fear and reward circuitry","volume":"108","author":"Abraham","year":"2014","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0020","doi-asserted-by":"crossref","first-page":"14871","DOI":"10.1523\/JNEUROSCI.3782-11.2011","article-title":"Effects of elevation of brain magnesium on fear conditioning, fear extinction, and synaptic plasticity in the infralimbic prefrontal cortex and lateral amygdala","volume":"31","author":"Abumaria","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0025","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00213-013-3099-4","article-title":"The effect of intranasal oxytocin treatment on conditioned fear extinction and recall in a healthy human sample","volume":"229","author":"Acheson","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0030","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0006-8993(99)01224-X","article-title":"Serotonin, via 5-HT2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release","volume":"825","author":"Aghajanian","year":"1999","journal-title":"Brain Res"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0035","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/j.1460-9568.2006.04603.x","article-title":"Enhancement of conditioned fear extinction by infusion of the GABA(A) agonist muscimol into the rat prefrontal cortex and amygdala","volume":"23","author":"Akirav","year":"2006","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0040","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1101\/lm.1565109","article-title":"D-cycloserine into the BLA reverses the impairing effects of exposure to stress on the extinction of contextual fear, but not conditioned taste aversion","volume":"16","author":"Akirav","year":"2009","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0045","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.cell.2007.10.039","article-title":"New nomenclature for chromatin-modifying enzymes","volume":"131","author":"Allis","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0050","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1152\/jn.00136.2011","article-title":"Physiological identification and infralimbic responsiveness of rat intercalated amygdala neurons","volume":"105","author":"Amir","year":"2011","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0055","doi-asserted-by":"crossref","first-page":"358","DOI":"10.3928\/00485713-20090526-01","article-title":"Genetics of PTSD: Fear conditioning as a model for future research","volume":"39","author":"Amstadter","year":"2009","journal-title":"Psychiatr Ann"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0065","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.neuron.2014.05.028","article-title":"A role for Tac2, NkB, and Nk3 receptor in normal and dysregulated fear memory consolidation","volume":"83","author":"Andero","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0070","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1176\/appi.ajp.2010.10030326","article-title":"Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning","volume":"168","author":"Andero","year":"2011","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0060","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1601-183X.2012.00801.x","article-title":"Fear extinction and BDNF: translating animal models of PTSD to the clinic","volume":"11","author":"Andero","year":"2012","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0075","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1037\/0022-006X.61.5.865","article-title":"Opioid antagonist affects behavioral effects of exposure in vivo","volume":"61","author":"Arntz","year":"1993","journal-title":"J Consult Clin Psychol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0080","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1046\/j.1460-9568.1999.00708.x","article-title":"A pre- and postsynaptic modulatory action of 5-HT and the 5-HT2A, 2C receptor agonist DOB on NMDA-evoked responses in the rat medial prefrontal cortex","volume":"11","author":"Arvanov","year":"1999","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0085","doi-asserted-by":"crossref","first-page":"9953","DOI":"10.1523\/JNEUROSCI.2134-04.2004","article-title":"Circuitry for associative plasticity in the amygdala involves endocannabinoid signaling","volume":"24","author":"Azad","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0090","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1017\/S1461145701002632","article-title":"Anxiety-like effects induced by acute fluoxetine, sertraline or m-CPP treatment are reversed by pretreatment with the 5-HT2C receptor antagonist SB-242084 but not the 5-HT1A receptor antagonist WAY-100635","volume":"4","author":"Bagdy","year":"2001","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0095","doi-asserted-by":"crossref","first-page":"5062","DOI":"10.1523\/JNEUROSCI.0079-12.2012","article-title":"HDAC1 regulates fear extinction in mice","volume":"32","author":"Bahari-Javan","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0100","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.bbr.2014.05.025","article-title":"d-Serine enhances fear extinction by increasing GluA2-containing AMPA receptor endocytosis","volume":"270","author":"Bai","year":"2014","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0110","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1037\/0735-7044.110.3.618","article-title":"The NMDA antagonist MK-801 blocks the extinction of Pavlovian fear conditioning","volume":"110","author":"Baker","year":"1996","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0105","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1101\/lm.029520.112","article-title":"Activation of BDNF signaling prevents the return of fear in female mice","volume":"20","author":"Baker-Andresen","year":"2013","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0115","doi-asserted-by":"crossref","first-page":"e480","DOI":"10.1038\/tp.2014.117","article-title":"Long-term exposure to intranasal oxytocin in a mouse autism model","volume":"4","author":"Bales","year":"2014","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0120","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/15622970601110273","article-title":"Meta-analysis of randomized controlled comparisons of psychopharmacological and psychological treatments for anxiety disorders","volume":"8","author":"Bandelow","year":"2007","journal-title":"World J Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0125","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3109\/13651501.2012.667114","article-title":"Guidelines for the pharmacological treatment of anxiety disorders, obsessive-compulsive disorder and posttraumatic stress disorder in primary care","volume":"16","author":"Bandelow","year":"2012","journal-title":"Int J Psychiatry Clin Pract"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0130","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1523\/JNEUROSCI.3154-04.2005","article-title":"Protons trap NR1\/NR2B NMDA receptors in a nonconducting state","volume":"25","author":"Banke","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0135","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.neulet.2004.08.046","article-title":"Behavioral effects of metyrapone on Pavlovian extinction","volume":"371","author":"Barrett","year":"2004","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0140","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/mp.2013.196","article-title":"Integrating the roles of long and small non-coding RNA in brain function and disease","volume":"19","author":"Barry","year":"2014","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0145","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.janxdis.2009.10.011","article-title":"Enhancing exposure therapy for anxiety disorders with glucocorticoids: from basic mechanisms of emotional learning to clinical applications","volume":"24","author":"Bentz","year":"2010","journal-title":"J Anxiety Disord"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0150","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.nlm.2005.12.008","article-title":"Enhancement of extinction memory consolidation: the role of the noradrenergic and GABAergic systems within the basolateral amygdala","volume":"86","author":"Berlau","year":"2006","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0155","doi-asserted-by":"crossref","first-page":"9335","DOI":"10.1523\/JNEUROSCI.1034-12.2012","article-title":"Dynorphins regulate fear memory: from mice to men","volume":"32","author":"Bilkei-Gorzo","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0160","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nn1058","article-title":"Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition","volume":"6","author":"Bissiere","year":"2003","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0165","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.euroneuro.2008.07.001","article-title":"Facilitation of contextual fear memory extinction and anti-anxiogenic effects of AM404 and cannabidiol in conditioned rats","volume":"18","author":"Bitencourt","year":"2008","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0170","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1192\/bjp.179.1.23","article-title":"Randomised controlled general practice trial of sertraline, exposure therapy and combined treatment in generalised social phobia","volume":"179","author":"Blomhoff","year":"2001","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0175","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.nlm.2011.02.006","article-title":"Block of glucocorticoid synthesis during re-activation inhibits extinction of an established fear memory","volume":"95","author":"Blundell","year":"2011","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0180","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.nlm.2013.12.009","article-title":"Opposing effects of d-cycloserine on fear despite a common extinction duration: Interactions between brain regions and behavior","volume":"113","author":"Bolkan","year":"2014","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0185","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1017\/S1461145710001501","article-title":"Histamine facilitates consolidation of fear extinction","volume":"14","author":"Bonini","year":"2011","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0190","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nn0602-849","article-title":"Sniffing neuropeptides: a transnasal approach to the human brain","volume":"5","author":"Born","year":"2002","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0195","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1037\/0735-7044.112.4.952","article-title":"The effects of cocaine, amphetamine, and the dopamine D1 receptor agonist SKF 38393 on fear extinction as measured with potentiated startle: implications for psychomotor stimulant psychosis","volume":"112","author":"Borowski","year":"1998","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0200","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1037\/0735-7044.104.1.44","article-title":"State-dependent fear extinction with two benzodiazepine tranquilizers","volume":"104","author":"Bouton","year":"1990","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0205","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.nlm.2008.07.003","article-title":"D-cycloserine facilitates context-specific fear extinction learning","volume":"90","author":"Bouton","year":"2008","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0215","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.physbeh.2012.03.004","article-title":"Neuropeptide regulation of fear and anxiety: Implications of cholecystokinin, endogenous opioids, and neuropeptide Y","volume":"107","author":"Bowers","year":"2012","journal-title":"Physiol Behav"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0210","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/npp.2014.225","article-title":"Interaction between the cholecystokinin and endogenous cannabinoid systems in cued fear expression and extinction retention","volume":"40","author":"Bowers","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0220","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1101\/lm.801108","article-title":"The histone deacetylase inhibitor valproic acid enhances acquisition, extinction, and reconsolidation of conditioned fear","volume":"15","author":"Bredy","year":"2008","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0225","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1101\/lm.500907","article-title":"Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear","volume":"14","author":"Bredy","year":"2007","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0230","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1017\/S1355617709990671","article-title":"Post-traumatic amnesia and the nature of post-traumatic stress disorder after mild traumatic brain injury","volume":"15","author":"Bryant","year":"2009","journal-title":"J Int Neuropsychol Soc"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0235","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/hup.2330","article-title":"Two weeks of pretreatment with escitalopram facilitates extinction learning in healthy individuals","volume":"28","author":"Bui","year":"2013","journal-title":"Hum Psychopharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0240","doi-asserted-by":"crossref","first-page":"4690","DOI":"10.1111\/bph.12779","article-title":"Mechanisms to medicines: elucidating neural and molecular substrates of fear extinction to identify novel treatments for anxiety disorders","volume":"171","author":"Bukalo","year":"2014","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0245","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.neuroscience.2013.05.050","article-title":"Acute and chronic effects of selective serotonin reuptake inhibitor treatment on fear conditioning: implications for underlying fear circuits","volume":"247","author":"Burghardt","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0250","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.biopsych.2012.10.012","article-title":"Chronic antidepressant treatment impairs the acquisition of fear extinction","volume":"73","author":"Burghardt","year":"2013","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0255","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.neuron.2007.02.021","article-title":"Consolidation of fear extinction requires NMDA receptor-dependent bursting in the ventromedial prefrontal cortex","volume":"53","author":"Burgos-Robles","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0260","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1101\/lm.886208","article-title":"Role of L-type Ca2+ channel isoforms in the extinction of conditioned fear","volume":"15","author":"Busquet","year":"2008","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0265","doi-asserted-by":"crossref","first-page":"5131","DOI":"10.1523\/JNEUROSCI.6100-10.2011","article-title":"Different fear states engage distinct networks within the intercalated cell clusters of the amygdala","volume":"31","author":"Busti","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0270","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/npp.2008.75","article-title":"Disruptive effect of midazolam on fear memory reconsolidation: decisive influence of reactivation time span and memory age","volume":"34","author":"Bustos","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0275","doi-asserted-by":"crossref","first-page":"9113","DOI":"10.1523\/JNEUROSCI.22-20-09113.2002","article-title":"L-type voltage-gated calcium channels are required for extinction, but not for acquisition or expression, of conditional fear in mice","volume":"22","author":"Cain","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0280","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1101\/lm.71504","article-title":"Adrenergic transmission facilitates extinction of conditional fear in mice","volume":"11","author":"Cain","year":"2004","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0285","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1517\/13543784.2012.704020","article-title":"Targeting memory processes with drugs to prevent or cure PTSD","volume":"21","author":"Cain","year":"2012","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0290","doi-asserted-by":"crossref","first-page":"6573","DOI":"10.1523\/JNEUROSCI.1497-06.2006","article-title":"Concomitant deficits in working memory and fear extinction are functionally dissociated from reduced anxiety in metabotropic glutamate receptor 7-deficient mice","volume":"26","author":"Callaerts-Vegh","year":"2006","journal-title":"J Neurosci"},{"issue":"Spec No 1","key":"10.1016\/j.pharmthera.2014.12.004_bb0295","doi-asserted-by":"crossref","first-page":"R95","DOI":"10.1093\/hmg\/ddl095","article-title":"The emerging science of epigenomics","volume":"15","author":"Callinan","year":"2006","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0300","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1038\/npp.2011.340","article-title":"Genetic strain differences in learned fear inhibition associated with variation in neuroendocrine, autonomic, and amygdala dendritic phenotypes","volume":"37","author":"Camp","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0305","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(03)03384-5","article-title":"Serotonin 2C receptors within the basolateral amygdala induce acute fear-like responses in an open-field environment","volume":"993","author":"Campbell","year":"2003","journal-title":"Brain Res"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0310","doi-asserted-by":"crossref","first-page":"4888","DOI":"10.1073\/pnas.0900835106","article-title":"Endocannabinoids in the rat basolateral amygdala enhance memory consolidation and enable glucocorticoid modulation of memory","volume":"106","author":"Campolongo","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0315","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1101\/lm.77904","article-title":"CB1 cannabinoid receptors modulate kinase and phosphatase activity during extinction of conditioned fear in mice","volume":"11","author":"Cannich","year":"2004","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0320","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neulet.2009.10.049","article-title":"Amphetamine and extinction of cued fear","volume":"468","author":"Carmack","year":"2010","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0325","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00221-013-3579-0","article-title":"Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning","volume":"228","author":"Catlow","year":"2013","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0330","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1124\/pr.57.4.5","article-title":"International Union of Pharmacology. XLVIII. Nomenclature and structure\u2013function relationships of voltage-gated calcium channels","volume":"57","author":"Catterall","year":"2005","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0335","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.brainresbull.2013.09.007","article-title":"The MAP(K) of fear: from memory consolidation to memory extinction","volume":"105","author":"Cestari","year":"2014","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0340","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0006-8993(91)90748-K","article-title":"Comparative anatomical distribution of 5-HT1A receptor mRNA and 5-HT1A binding in rat brain\u2014A combined in situ hybridisation\/in vitro receptor autoradiographic study","volume":"561","author":"Chalmers","year":"1991","journal-title":"Brain Res"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0345","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1037\/a0014988","article-title":"Conditioned stimulus familiarity determines effects of MK-801 on fear extinction","volume":"123","author":"Chan","year":"2009","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0350","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.brat.2010.03.007","article-title":"Need for speed: Evaluating slopes of OCD recovery in behavior therapy enhanced with d-cycloserine","volume":"48","author":"Chasson","year":"2010","journal-title":"Behav Res Ther"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0355","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1038\/npp.2012.3","article-title":"Prevention of stress-impaired fear extinction through neuropeptide s action in the lateral amygdala","volume":"37","author":"Chauveau","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0360","doi-asserted-by":"crossref","first-page":"11018","DOI":"10.1021\/bi00110a002","article-title":"Direct identification of the active-site nucleophile in a DNA (cytosine-5)-methyltransferase","volume":"30","author":"Chen","year":"1991","journal-title":"Biochemistry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0370","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/sj.npp.1300655","article-title":"Enhancing cannabinoid neurotransmission augments the extinction of conditioned fear","volume":"30","author":"Chhatwal","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0380","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/npp.2008.97","article-title":"Functional interactions between endocannabinoid and CCK neurotransmitter systems may be critical for extinction learning","volume":"34","author":"Chhatwal","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0365","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1523\/JNEUROSCI.3301-04.2005","article-title":"Regulation of gephyrin and GABAA receptor binding within the amygdala after fear acquisition and extinction","volume":"25","author":"Chhatwal","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0375","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/nn1718","article-title":"Amygdala BDNF signaling is required for consolidation but not encoding of extinction","volume":"9","author":"Chhatwal","year":"2006","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0385","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1073\/pnas.0909359107","article-title":"Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear","volume":"107","author":"Choi","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0390","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1126\/science.1175371","article-title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions","volume":"325","author":"Choudhary","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0395","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.cpr.2006.10.002","article-title":"Treatment of specific phobia in adults","volume":"27","author":"Choy","year":"2007","journal-title":"Clin Psychol Rev"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0400","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/365855a0","article-title":"Phosphorylated CREB binds specifically to the nuclear protein CBP","volume":"365","author":"Chrivia","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0405","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nature09559","article-title":"Encoding of conditioned fear in central amygdala inhibitory circuits","volume":"468","author":"Ciocchi","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0410","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4088\/JCP.v65n0202","article-title":"Benzodiazepine prescription practices and substance abuse in persons with severe mental illness","volume":"65","author":"Clark","year":"2004","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0415","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.nlm.2011.06.012","article-title":"Glucocorticoids are required for extinction of predator stress-induced hyperarousal","volume":"96","author":"Clay","year":"2011","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0420","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1101\/lm.2049511","article-title":"Kappa opioid receptors mediate where fear is expressed following extinction training","volume":"18","author":"Cole","year":"2011","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0425","doi-asserted-by":"crossref","first-page":"e58701","DOI":"10.1371\/journal.pone.0058701","article-title":"Ventral hippocampal kappa opioid receptors mediate the renewal of fear following extinction in the rat","volume":"8","author":"Cole","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0430","doi-asserted-by":"crossref","first-page":"8978","DOI":"10.1523\/JNEUROSCI.2246-05.2005","article-title":"Hippocampal inactivation disrupts the acquisition and contextual encoding of fear extinction","volume":"25","author":"Corcoran","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0435","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/(SICI)1096-9861(19990628)409:2<187::AID-CNE2>3.0.CO;2-P","article-title":"Cellular and subcellular distribution of the serotonin 5-HT2A receptor in the central nervous system of adult rat","volume":"409","author":"Cornea-Hebert","year":"1999","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0440","doi-asserted-by":"crossref","first-page":"13039","DOI":"10.1523\/JNEUROSCI.0930-12.2012","article-title":"MSK1 regulates homeostatic and experience-dependent synaptic plasticity","volume":"32","author":"Correa","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0445","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1038\/sj.npp.1301642","article-title":"Disruption of AMPA receptor endocytosis impairs the extinction, but not acquisition of learned fear","volume":"33","author":"Dalton","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0450","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.neuropharm.2011.09.001","article-title":"NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear","volume":"62","author":"Dalton","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0455","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s00213-012-2955-y","article-title":"Cannabidiol enhances consolidation of explicit fear extinction in humans","volume":"226","author":"Das","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0460","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1001\/archpsyc.61.10.1005","article-title":"Fluoxetine, comprehensive cognitive behavioral therapy, and placebo in generalized social phobia","volume":"61","author":"Davidson","year":"2004","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0475","doi-asserted-by":"crossref","first-page":"13582","DOI":"10.1523\/JNEUROSCI.0809-12.2012","article-title":"L-type voltage-gated calcium channels in the basolateral amygdala are necessary for fear extinction","volume":"32","author":"Davis","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0470","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.neuropharm.2012.07.038","article-title":"Role of mGluR4 in acquisition of fear learning and memory","volume":"66","author":"Davis","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0465","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1101\/lm.1079308","article-title":"Yohimbine impairs extinction of cocaine-conditioned place preference in an alpha2-adrenergic receptor independent process","volume":"15","author":"Davis","year":"2008","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0480","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.neuron.2011.05.019","article-title":"Epigenetic mechanisms in cognition","volume":"70","author":"Day","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0485","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S0028-3908(03)00190-4","article-title":"L-DOPA increases noradrenaline turnover in central and peripheral nervous systems","volume":"45","author":"Dayan","year":"2003","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0490","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1176\/ajp.152.5.683","article-title":"Treatment of panic disorder with agoraphobia: Comparison of fluvoxamine, placebo, and psychological panic management combined with exposure and of exposure in vivo alone","volume":"152","author":"de Beurs","year":"1995","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0495","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.neuropharm.2012.05.039","article-title":"A current overview of cannabinoids and glucocorticoids in facilitating extinction of aversive memories: Potential extinction enhancers","volume":"64","author":"de Bitencourt","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0500","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.1073\/pnas.1400423111","article-title":"Hippocampal molecular mechanisms involved in the enhancement of fear extinction caused by exposure to novelty","volume":"111","author":"de Carvalho Myskiw","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0505","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.biopsych.2012.02.033","article-title":"A randomized placebo-controlled trial of D-cycloserine to enhance exposure therapy for posttraumatic stress disorder","volume":"71","author":"de Kleine","year":"2012","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0510","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1016\/j.neuroscience.2008.05.005","article-title":"Opposite action of hippocampal CB1 receptors in memory reconsolidation and extinction","volume":"154","author":"de Oliveira Alvares","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0515","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1177\/0269881111400642","article-title":"Anxiolytic-like effect of oxytocin in the simulated public speaking test","volume":"26","author":"de Oliveira","year":"2012","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0520","doi-asserted-by":"crossref","first-page":"6621","DOI":"10.1073\/pnas.1018214108","article-title":"Glucocorticoids enhance extinction-based psychotherapy","volume":"108","author":"de Quervain","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0525","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.neuroscience.2004.08.018","article-title":"Disruption of reconsolidation but not consolidation of auditory fear conditioning by noradrenergic blockade in the amygdala","volume":"129","author":"Debiec","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0530","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1023\/A:1007570509232","article-title":"Blood\u2013brain barrier transport of 125I-labeled basic fibroblast growth factor","volume":"17","author":"Deguchi","year":"2000","journal-title":"Pharm Res"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0535","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1037\/bne0000022","article-title":"A comparison of the short- and long-term effects of corticosterone exposure on extinction in adolescence versus adulthood","volume":"128","author":"Den","year":"2014","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0540","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00213-010-2134-y","article-title":"Chronic treatment with fluoxetine prevents the return of extinguished auditory-cued conditioned fear","volume":"215","author":"Deschaux","year":"2011","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0545","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00213-012-2806-x","article-title":"Post-extinction fluoxetine treatment prevents stress-induced reemergence of extinguished fear","volume":"225","author":"Deschaux","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0550","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ejphar.2007.08.017","article-title":"Pharmacological properties of the active metabolites of the antidepressants desipramine and citalopram","volume":"576","author":"Deupree","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0555","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.1523\/JNEUROSCI.23-12-04850.2003","article-title":"Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: A fast feedback mechanism","volume":"23","author":"Di","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0560","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1038\/npp.2013.317","article-title":"D-cycloserine augmentation of exposure therapy for post-traumatic stress disorder: A pilot randomized clinical trial","volume":"39","author":"Difede","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0575","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.bbr.2013.04.045","article-title":"Infusion of cannabidiol into infralimbic cortex facilitates fear extinction via CB1 receptors","volume":"250","author":"Do Monte","year":"2013","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0580","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.neuropharm.2012.05.025","article-title":"Neural substrates for the distinct effects of presynaptic group III metabotropic glutamate receptors on extinction of contextual fear conditioning in mice","volume":"66","author":"Dobi","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0585","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1126\/science.1063395","article-title":"Signaling to the nucleus by an L-type calcium channel\u2013calmodulin complex through the MAP kinase pathway","volume":"294","author":"Dolmetsch","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0565","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.bbr.2010.03.014","article-title":"Impairment of contextual conditioned fear extinction after microinjection of alpha-1-adrenergic blocker prazosin into the medial prefrontal cortex","volume":"211","author":"Do-Monte","year":"2010","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0570","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.nlm.2010.07.004","article-title":"Role of beta-adrenergic receptors in the ventromedial prefrontal cortex during contextual fear extinction in rats","volume":"94","author":"Do-Monte","year":"2010","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0590","series-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"DSM-5","year":"2013"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0595","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.expneurol.2010.01.017","article-title":"CB1 receptor deficiency decreases wheel-running activity: Consequences on emotional behaviours and hippocampal neurogenesis","volume":"224","author":"Dubreucq","year":"2010","journal-title":"Exp Neurol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0600","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11055-009-9226-3","article-title":"Effects of activation and blockade of dopamine receptors on the extinction of a passive avoidance reaction in mice with a depressive-like state","volume":"40","author":"Dubrovina","year":"2010","journal-title":"Neurosci Behav Physiol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0605","doi-asserted-by":"crossref","first-page":"5645","DOI":"10.2174\/138161212803530899","article-title":"Pharmacological innovations for posttraumatic stress disorder and medication-enhanced psychotherapy","volume":"18","author":"Dunlop","year":"2012","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0610","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.neuron.2014.04.042","article-title":"Amygdala microcircuits controlling learned fear","volume":"82","author":"Duvarci","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0615","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.2174\/138161209788168074","article-title":"Tachykinin receptors as therapeutic targets in stress-related disorders","volume":"15","author":"Ebner","year":"2009","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0620","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1016\/j.brat.2007.02.011","article-title":"Contextual control of human fear associations in a renewal paradigm","volume":"45","author":"Effting","year":"2007","journal-title":"Behav Res Ther"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0625","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1037\/0022-006X.56.2.287","article-title":"Endogenous opiate system and systematic desensitization","volume":"56","author":"Egan","year":"1988","journal-title":"J Consult Clin Psychol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0630","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.neuron.2009.05.026","article-title":"Amygdala inhibitory circuits and the control of fear memory","volume":"62","author":"Ehrlich","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0635","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0006-8993(00)03234-0","article-title":"Prolonged fear responses in mice lacking dopamine D1 receptor","volume":"892","author":"El-Ghundi","year":"2001","journal-title":"Brain Res"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0640","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.neuropharm.2012.06.061","article-title":"5-HT1A and 5-HT7 receptor crosstalk in the regulation of emotional memory: Implications for effects of selective serotonin reuptake inhibitors","volume":"63","author":"Eriksson","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0645","first-page":"315","article-title":"Effects of systemic administration of oxytocin on contextual fear extinction in a rat model of post-traumatic stress disorder","volume":"4","author":"Eskandarian","year":"2013","journal-title":"Basic Clin Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0650","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1523\/JNEUROSCI.12-03-00854.1992","article-title":"Extinction of fear-potentiated startle: Blockade by infusion of an NMDA antagonist into the amygdala","volume":"12","author":"Falls","year":"1992","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0655","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/da.22132","article-title":"Difficult-to-treat pediatric obsessive\u2013compulsive disorder: Feasibility and preliminary results of a randomized pilot trial of D-cycloserine-augmented behavior therapy","volume":"30","author":"Farrell","year":"2013","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0660","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0022-3565(25)23627-8","article-title":"The dopamine-1 agonist, SKF 82526, stimulates phospholipase-C activity independent of adenylate cyclase","volume":"248","author":"Felder","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0665","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0149-7634(99)00016-0","article-title":"The neuroanatomical and neurochemical basis of conditioned fear","volume":"23","author":"Fendt","year":"1999","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0670","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.neuropharm.2013.04.052","article-title":"Differential roles of mGlu(7) and mGlu(8) in amygdala-dependent behavior and physiology","volume":"72","author":"Fendt","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0675","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/sj.mp.4002073","article-title":"mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity","volume":"13","author":"Fendt","year":"2008","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0680","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/sj.npp.1300066","article-title":"Prefrontocortical dopamine loss in rats delays long-term extinction of contextual conditioned fear, and reduces social interaction without affecting short-term social interaction memory","volume":"28","author":"Fernandez Espejo","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0685","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1097\/FBP.0b013e32830dc0c7","article-title":"Affective and cognitive effects of global deletion of alpha3-containing gamma-aminobutyric acid-A receptors","volume":"19","author":"Fiorelli","year":"2008","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0690","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.bbr.2012.04.015","article-title":"Modulation of the extinction of two different fear-motivated tasks in three distinct brain areas","volume":"232","author":"Fiorenza","year":"2012","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0700","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.nlm.2006.08.003","article-title":"Hippocampal Mek\/Erk signaling mediates extinction of contextual freezing behavior","volume":"87","author":"Fischer","year":"2007","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0695","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.tips.2010.09.003","article-title":"Targeting the correct HDAC(s) to treat cognitive disorders","volume":"31","author":"Fischer","year":"2010","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0705","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.brainresbull.2013.12.007","article-title":"Can fear extinction be enhanced? A review of pharmacological and behavioral findings","volume":"105","author":"Fitzgerald","year":"2014","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0710","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.nlm.2013.11.002","article-title":"Prefrontal single-unit firing associated with deficient extinction in mice","volume":"113","author":"Fitzgerald","year":"2014","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0715","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1038\/npp.2014.146","article-title":"The hypocretin\/orexin system mediates the extinction of fear memories","volume":"39","author":"Flores","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0720","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/cercor\/bhq147","article-title":"Memory for fear extinction requires mGluR5-mediated activation of infralimbic neurons","volume":"21","author":"Fontanez-Nuin","year":"2011","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0725","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1046\/j.1460-9568.1999.00481.x","article-title":"GABAB-receptor splice variants GB1a and GB1b in rat brain: Developmental regulation, cellular distribution and extrasynaptic localization","volume":"11","author":"Fritschy","year":"1999","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0730","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.jpsychires.2012.01.026","article-title":"Vorinostat, a histone deacetylase inhibitor, facilitates fear extinction and enhances expression of the hippocampal NR2B-containing NMDA receptor gene","volume":"46","author":"Fujita","year":"2012","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0735","doi-asserted-by":"crossref","first-page":"4973","DOI":"10.1074\/jbc.M107848200","article-title":"Enhancement of nuclear factor-kappa B acetylation by coactivator p300 and HIV-1 Tat proteins","volume":"277","author":"Furia","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0740","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/hipo.20656","article-title":"Beta-adrenergic receptors link NO\/sGC\/PKG signaling to BDNF expression during the consolidation of object recognition long-term memory","volume":"20","author":"Furini","year":"2010","journal-title":"Hippocampus"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0745","doi-asserted-by":"crossref","first-page":"16330","DOI":"10.1073\/pnas.1119261109","article-title":"Cell-type specific deletion of GABA(A)alpha1 in corticotropin-releasing factor-containing neurons enhances anxiety and disrupts fear extinction","volume":"109","author":"Gafford","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0750","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/hipo.20728","article-title":"Deletion of the L-type calcium channel Ca(V) 1.3 but not Ca(V) 1.2 results in a diminished sAHP in mouse CA1 pyramidal neurons","volume":"21","author":"Gamelli","year":"2011","journal-title":"Hippocampus"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0755","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/j.psyneuen.2013.01.014","article-title":"Cannabinoids and traumatic stress modulation of contextual fear extinction and GR expression in the amygdala-hippocampal-prefrontal circuit","volume":"38","author":"Ganon-Elazar","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0760","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/nature09271","article-title":"A novel pathway regulates memory and plasticity via SIRT1 and miR-134","volume":"466","author":"Gao","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0765","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.biopsych.2008.11.001","article-title":"Positive allosteric modulation of mGluR5 receptors facilitates extinction of a cocaine contextual memory","volume":"65","author":"Gass","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0770","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1523\/JNEUROSCI.4175-04.2005","article-title":"Beta-adrenergic receptor activation facilitates induction of a protein synthesis-dependent late phase of long-term potentiation","volume":"25","author":"Gelinas","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0775","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1152\/physrev.2001.81.2.629","article-title":"The oxytocin receptor system: Structure, function, and regulation","volume":"81","author":"Gimpl","year":"2001","journal-title":"Physiol Rev"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0780","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3389\/fnbeh.2013.00031","article-title":"Contextual fear conditioning in virtual reality is affected by 5HTTLPR and NPSR1 polymorphisms: Effects on fear-potentiated startle","volume":"7","author":"Glotzbach-Schoon","year":"2013","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0785","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.nlm.2008.01.001","article-title":"Deficits in acquisition and extinction of conditioned responses in mGluR7 knockout mice","volume":"90","author":"Goddyn","year":"2008","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0790","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1126\/science.1174146","article-title":"Perineuronal nets protect fear memories from erasure","volume":"325","author":"Gogolla","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0795","doi-asserted-by":"crossref","first-page":"783","DOI":"10.2466\/pr0.1977.40.3.783","article-title":"Effect of chlordiazepoxide administered early in extinction on subsequent extinction of a conditioned emotional response in rats: Implications for human clinical use","volume":"40","author":"Goldman","year":"1977","journal-title":"Psychol Rep"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0800","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.nlm.2010.02.007","article-title":"Polyaminergic agents modulate contextual fear extinction in rats","volume":"93","author":"Gomes","year":"2010","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0805","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1101\/lm.82404","article-title":"Extinction memory improvement by the metabolic enhancer methylene blue","volume":"11","author":"Gonzalez-Lima","year":"2004","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0810","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/npp.2008.123","article-title":"A history of corticosterone exposure regulates fear extinction and cortical NR2B, GluR2\/3, and BDNF","volume":"34","author":"Gourley","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0815","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.cell.2013.12.020","article-title":"Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories","volume":"156","author":"Graff","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0840","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1111\/j.1476-5381.2010.01175.x","article-title":"Pharmacological enhancement of fear reduction: Preclinical models","volume":"164","author":"Graham","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0820","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1038\/npp.2009.14","article-title":"Acute systemic fibroblast growth factor-2 enhances long-term extinction of fear and reduces reinstatement in rats","volume":"34","author":"Graham","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0825","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1038\/npp.2010.3","article-title":"Fibroblast growth factor-2 enhances extinction and reduces renewal of conditioned fear","volume":"35","author":"Graham","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0830","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.neuroscience.2011.05.041","article-title":"Memory of fearful events: The role of fibroblast growth factor-2 in fear acquisition and extinction","volume":"189","author":"Graham","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0835","doi-asserted-by":"crossref","first-page":"14151","DOI":"10.1523\/JNEUROSCI.3014-11.2011","article-title":"Intraamygdala infusion of fibroblast growth factor 2 enhances extinction and reduces renewal and reinstatement in adult rats","volume":"31","author":"Graham","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0845","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1124\/mol.109.061333","article-title":"Is there a future for histone deacetylase inhibitors in the pharmacotherapy of psychiatric disorders?","volume":"77","author":"Grayson","year":"2010","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0850","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nrd4075","article-title":"50 years of hurdles and hope in anxiolytic drug discovery","volume":"12","author":"Griebel","year":"2013","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0855","first-page":"CD006815","article-title":"Hydroxyzine for generalised anxiety disorder","author":"Guaiana","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0860","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0092-8674(02)01074-7","article-title":"Integration of long-term-memory-related synaptic plasticity involves bidirectional regulation of gene expression and chromatin structure","volume":"111","author":"Guan","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0865","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.brat.2006.07.005","article-title":"A randomized controlled trial of the effect of D-cycloserine on extinction and fear conditioning in humans","volume":"45","author":"Guastella","year":"2007","journal-title":"Behav Res Ther"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0870","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.biopsych.2007.11.011","article-title":"A randomized controlled trial of D-cycloserine enhancement of exposure therapy for social anxiety disorder","volume":"63","author":"Guastella","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0875","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.mcn.2011.03.009","article-title":"ERK-associated changes of AP-1 proteins during fear extinction","volume":"47","author":"Guedea","year":"2011","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0880","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s00213-006-0376-5","article-title":"Nitric oxide is involved in the memory facilitation induced by spermidine in rats","volume":"186","author":"Guerra","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0885","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.tips.2013.08.008","article-title":"Amygdala FAAH and anandamide: Mediating protection and recovery from stress","volume":"34","author":"Gunduz-Cinar","year":"2013","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0890","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/mp.2012.72","article-title":"Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity","volume":"18","author":"Gunduz-Cinar","year":"2013","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0895","article-title":"GABA receptor-acting neurosteroids: A role in the development and regulation of the stress response","author":"Gunn","year":"2014","journal-title":"Front Neuroendocrinol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0900","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nn.3607","article-title":"Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain","volume":"17","author":"Guo","year":"2014","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0905","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1111\/ejn.12197","article-title":"Effect of D-cycloserine in conjunction with fear extinction training on extracellular signal-regulated kinase activation in the medial prefrontal cortex and amygdala in rat","volume":"37","author":"Gupta","year":"2013","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0910","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.euroneuro.2011.08.008","article-title":"Cost of disorders of the brain in Europe 2010","volume":"21","author":"Gustavsson","year":"2011","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0915","doi-asserted-by":"crossref","first-page":"12682","DOI":"10.1523\/JNEUROSCI.2305-08.2008","article-title":"The role of neuropeptide Y in the expression and extinction of fear-potentiated startle","volume":"28","author":"Gutman","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0920","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/16506073.2012.711770","article-title":"The effect of D-cycloserine on subliminal cue exposure in spider fearful individuals","volume":"41","author":"Gutner","year":"2012","journal-title":"Cogn Behav Ther"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0925","doi-asserted-by":"crossref","first-page":"E2428","DOI":"10.1073\/pnas.1303061110","article-title":"Single dose of L-dopa makes extinction memories context-independent and prevents the return of fear","volume":"110","author":"Haaker","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0930","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.nlm.2011.04.009","article-title":"Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity","volume":"96","author":"Haggarty","year":"2011","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0935","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/nn.3728","article-title":"Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory","volume":"17","author":"Hait","year":"2014","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0940","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1101\/lm.56103","article-title":"Improvements in hippocampal-dependent learning and decremental attention in 5-HT(3) receptor overexpressing mice","volume":"10","author":"Harrell","year":"2003","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0945","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s002130050745","article-title":"Evidence that GABA transmission mediates context-specific extinction of learned fear","volume":"140","author":"Harris","year":"1998","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0950","doi-asserted-by":"crossref","first-page":"20106","DOI":"10.1016\/S0021-9258(17)30476-3","article-title":"Insulin regulation of hexose transport in mouse 3T3-L1 cells expressing the human HepG2 glucose transporter","volume":"265","author":"Harrison","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0955","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1101\/lm.1154409","article-title":"Systemic or intra-amygdala injection of a benzodiazepine (midazolam) impairs extinction but spares re-extinction of conditioned fear responses","volume":"16","author":"Hart","year":"2009","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0960","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1101\/lm.1682410","article-title":"Systemic or intra-amygdala infusion of the benzodiazepine, midazolam, impairs learning, but facilitates re-learning to inhibit fear responses in extinction","volume":"17","author":"Hart","year":"2010","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0965","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.brat.2014.02.004","article-title":"Benzodiazepine treatment can impair or spare extinction, depending on when it is given","volume":"56","author":"Hart","year":"2014","journal-title":"Behav Res Ther"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0970","doi-asserted-by":"crossref","first-page":"5493","DOI":"10.1073\/pnas.1202044109","article-title":"Serotonin transporter polyadenylation polymorphism modulates the retention of fear extinction memory","volume":"109","author":"Hartley","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0975","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.bcp.2010.07.037","article-title":"Role of monoamine oxidase, nitric oxide synthase and regional brain monoamines in the antidepressant-like effects of methylene blue and selected structural analogues","volume":"80","author":"Harvey","year":"2010","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0980","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nature09553","article-title":"Genetic dissection of an amygdala microcircuit that gates conditioned fear","volume":"468","author":"Haubensak","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0985","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1192\/bjp.182.4.312","article-title":"Exposure therapy and sertraline in social phobia: I-year follow-up of a randomised controlled trial","volume":"182","author":"Haug","year":"2003","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0990","doi-asserted-by":"crossref","first-page":"9203","DOI":"10.1073\/pnas.1205242109","article-title":"Exposure therapy triggers lasting reorganization of neural fear processing","volume":"109","author":"Hauner","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb0995","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.nlm.2012.09.005","article-title":"Baclofen administration alters fear extinction and GABAergic protein levels","volume":"98","author":"Heaney","year":"2012","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1000","doi-asserted-by":"crossref","first-page":"8074","DOI":"10.1523\/JNEUROSCI.4904-07.2008","article-title":"Impaired fear extinction learning and cortico-amygdala circuit abnormalities in a common genetic mouse strain","volume":"28","author":"Hefner","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1005","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0006-3223(03)00465-7","article-title":"Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress","volume":"54","author":"Heinrichs","year":"2003","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1015","doi-asserted-by":"crossref","first-page":"e181","DOI":"10.1038\/tp.2012.101","article-title":"In vivo knockdown of GAD67 in the amygdala disrupts fear extinction and the anxiolytic-like effect of diazepam in mice","volume":"2","author":"Heldt","year":"2012","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1010","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1111\/j.1460-9568.2007.05970.x","article-title":"Training-induced changes in the expression of GABAA-associated genes in the amygdala after the acquisition and extinction of Pavlovian fear","volume":"26","author":"Heldt","year":"2007","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1020","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/sj.mp.4001957","article-title":"Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories","volume":"12","author":"Heldt","year":"2007","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1025","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1017\/S1461145702003061","article-title":"Pilot-controlled trial of D-cycloserine for the treatment of post-traumatic stress disorder","volume":"5","author":"Heresco-Levy","year":"2002","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1035","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/nature07166","article-title":"Switching on and off fear by distinct neuronal circuits","volume":"454","author":"Herry","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1040","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1460-9568.2010.07101.x","article-title":"Neuronal circuits of fear extinction","volume":"31","author":"Herry","year":"2010","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1030","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1460-9568.2006.04893.x","article-title":"Extinction of auditory fear conditioning requires MAPK\/ERK activation in the basolateral amygdala","volume":"24","author":"Herry","year":"2006","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1045","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.neuroscience.2006.01.059","article-title":"Brain activation pattern induced by stimulation of L-type Ca2+-channels: Contribution of Ca(V)1.3 and Ca(V)1.2 isoforms","volume":"139","author":"Hetzenauer","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1050","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.nlm.2008.03.003","article-title":"Microinfusion of the D1 receptor antagonist, SCH23390 into the IL but not the BLA impairs consolidation of extinction of auditory fear conditioning","volume":"90","author":"Hikind","year":"2008","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1055","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ejphar.2005.10.058","article-title":"Chronic corticosterone treatment increases the endocannabinoid 2-arachidonylglycerol in the rat amygdala","volume":"528","author":"Hill","year":"2005","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1060","doi-asserted-by":"crossref","first-page":"10506","DOI":"10.1523\/JNEUROSCI.0496-11.2011","article-title":"Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response","volume":"31","author":"Hill","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1065","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/msj.20041","article-title":"Anxiety disorders: A comprehensive review of pharmacotherapies","volume":"75","author":"Hoffman","year":"2008","journal-title":"Mt Sinai J Med"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1070","year":"2012"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1075","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/da.22257","article-title":"D-cycloserine for treating anxiety disorders: Making good exposures better and bad exposures worse","volume":"31","author":"Hofmann","year":"2014","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1090","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1001\/archpsyc.63.3.298","article-title":"Augmentation of exposure therapy with D-cycloserine for social anxiety disorder","volume":"63","author":"Hofmann","year":"2006","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1080","doi-asserted-by":"crossref","first-page":"621","DOI":"10.4088\/JCP.v69n0415","article-title":"Cognitive-behavioral therapy for adult anxiety disorders: A meta-analysis of randomized placebo-controlled trials","volume":"69","author":"Hofmann","year":"2008","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1095","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1176\/appi.ajp.2013.12070974","article-title":"D-Cycloserine as an augmentation strategy with cognitive-behavioral therapy for social anxiety disorder","volume":"170","author":"Hofmann","year":"2013","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1085","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/2045-5380-3-11","article-title":"D-Cycloserine as an augmentation strategy for cognitive behavioral therapy of anxiety disorders","volume":"3","author":"Hofmann","year":"2013","journal-title":"Biol Mood Anxiety Disord"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1100","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1056\/NEJMoa0903326","article-title":"Morphine use after combat injury in Iraq and post-traumatic stress disorder","volume":"362","author":"Holbrook","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1115","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.tips.2003.09.011","article-title":"Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders","volume":"24","author":"Holmes","year":"2003","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1105","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.tips.2009.10.003","article-title":"Pharmacological facilitation of fear extinction and the search for adjunct treatments for anxiety disorders\u2014The case of yohimbine","volume":"31","author":"Holmes","year":"2010","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1110","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.tins.2012.11.003","article-title":"Individual differences in recovery from traumatic fear","volume":"36","author":"Holmes","year":"2013","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1120","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1210\/en.2006-0933","article-title":"GPR39 signaling is stimulated by zinc ions but not by obestatin","volume":"148","author":"Holst","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1125","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1101\/lm.1668310","article-title":"Blockade of dopamine activity in the nucleus accumbens impairs learning extinction of conditioned fear","volume":"17","author":"Holtzman-Assif","year":"2010","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1130","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1471-2202-15-86","article-title":"Melatonin facilitates extinction, but not acquisition or expression, of conditional cued fear in rats","volume":"15","author":"Huang","year":"2014","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1135","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1126\/science.1105636","article-title":"Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala","volume":"308","author":"Huber","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1140","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/syn.20448","article-title":"Time course of extracellular catecholamine and glutamate levels in the rat medial prefrontal cortex during and after extinction of conditioned fear","volume":"61","author":"Hugues","year":"2007","journal-title":"Synapse"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1145","series-title":"World Health Organisation International classification of diseases","author":"ICD-10","year":"1994"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1150","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0022-3565(25)23814-9","article-title":"Steroid potentiation and inhibition of N-methyl-D-aspartate receptor-mediated intracellular Ca++ responses: Structure\u2013activity studies","volume":"271","author":"Irwin","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1155","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1460-9568.2011.07921.x","article-title":"Early postnatal stress alters extracellular signal-regulated kinase signaling in the corticolimbic system modulating emotional circuitry in adult rats","volume":"35","author":"Ishikawa","year":"2012","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1160","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1126\/science.1210597","article-title":"Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine","volume":"333","author":"Ito","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1165","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.nlm.2012.03.005","article-title":"Histone acetylation rescues contextual fear conditioning in nNOS KO mice and accelerates extinction of cued fear conditioning in wild type mice","volume":"97","author":"Itzhak","year":"2012","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1170","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ejphar.2012.09.028","article-title":"Effects of serotonergic terminal lesion in the amygdala on conditioned fear and innate fear in rats","volume":"696","author":"Izumi","year":"2012","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1175","doi-asserted-by":"crossref","first-page":"8800","DOI":"10.1523\/JNEUROSCI.2076-06.2006","article-title":"GABA(B(1)) receptor isoforms differentially mediate the acquisition and extinction of aversive taste memories","volume":"26","author":"Jacobson","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/lm.1923211","article-title":"Deepened extinction following compound stimulus presentation: Noradrenergic modulation","volume":"18","author":"Janak","year":"2011","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1185","doi-asserted-by":"crossref","first-page":"10396","DOI":"10.1523\/JNEUROSCI.5539-12.2013","article-title":"Thy1-expressing neurons in the basolateral amygdala may mediate fear inhibition","volume":"33","author":"Jasnow","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1190","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0006-8993(99)02388-4","article-title":"Acquisition, extinction, and reinstatement of Pavlovian fear conditioning: The roles of the NMDA receptor and nitric oxide","volume":"857","author":"Johnson","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1195","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.neuropharm.2011.02.023","article-title":"Impaired safety signal learning may be a biomarker of PTSD","volume":"62","author":"Jovanovic","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1200","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.neuron.2008.07.002","article-title":"Neuropeptide S-mediated control of fear expression and extinction: Role of intercalated GABAergic neurons in the amygdala","volume":"59","author":"Jungling","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1205","doi-asserted-by":"crossref","first-page":"e84165","DOI":"10.1371\/journal.pone.0084165","article-title":"Molecular mechanisms mediating a deficit in recall of fear extinction in adult mice exposed to cocaine in utero","volume":"8","author":"Kabir","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1210","doi-asserted-by":"crossref","first-page":"6677","DOI":"10.1523\/JNEUROSCI.0153-06.2006","article-title":"Cannabinoid CB1 receptor mediates fear extinction via habituation-like processes","volume":"26","author":"Kamprath","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1215","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1126\/science.1214592","article-title":"Fear erasure in mice requires synergy between antidepressant drugs and extinction training","volume":"334","author":"Karpova","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1220","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1046\/j.1460-9568.2002.02172.x","article-title":"Glucocorticoids alter calcium conductances and calcium channel subunit expression in basolateral amygdala neurons","volume":"16","author":"Karst","year":"2002","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1225","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0304-3940(93)90565-3","article-title":"Psychological stress increases serotonin release in the rat amygdala and prefrontal cortex assessed by in vivo microdialysis","volume":"162","author":"Kawahara","year":"1993","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1235","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1017\/S0033291712000025","article-title":"Lifetime co-morbidity of DSM-IV disorders in the US National Comorbidity Survey Replication Adolescent Supplement (NCS-A)","volume":"42","author":"Kessler","year":"2012","journal-title":"Psychol Med"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1230","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","article-title":"Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1240","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.bbrc.2007.01.125","article-title":"Blockade of amygdala metabotropic glutamate receptor subtype 1 impairs fear extinction","volume":"355","author":"Kim","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1245","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1037\/0735-7044.121.1.131","article-title":"A developmental dissociation of context and GABA effects on extinguished fear in rats","volume":"121","author":"Kim","year":"2007","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1250","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1037\/a0015237","article-title":"Expression of renewal is dependent on the extinction-test interval rather than the acquisition-extinction interval","volume":"123","author":"Kim","year":"2009","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1255","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nn.2271","article-title":"Beyond extinction: Erasing human fear responses and preventing the return of fear","volume":"12","author":"Kindt","year":"2009","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1260","doi-asserted-by":"crossref","first-page":"11489","DOI":"10.1523\/JNEUROSCI.3984-05.2005","article-title":"Oxytocin modulates neural circuitry for social cognition and fear in humans","volume":"25","author":"Kirsch","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1265","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1177\/0269881111431624","article-title":"Testing the effects of Delta9-THC and D-cycloserine on extinction of conditioned fear in humans","volume":"26","author":"Klumpers","year":"2012","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1270","doi-asserted-by":"crossref","first-page":"17093","DOI":"10.1073\/pnas.1202087109","article-title":"Functional anatomy of neural circuits regulating fear and extinction","volume":"109","author":"Knapska","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1275","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.neuron.2011.11.030","article-title":"Evoked axonal oxytocin release in the central amygdala attenuates fear response","volume":"73","author":"Knobloch","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1280","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0306-4522(85)90049-1","article-title":"The cytoarchitecture, histochemistry and projections of the tuberomammillary nucleus in the rat","volume":"16","author":"Kohler","year":"1985","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/lm.032193.113","article-title":"The 5-HT3A receptor is essential for fear extinction","volume":"21","author":"Kondo","year":"2014","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1290","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/npp.2013.191","article-title":"Learning not to fear: Neural correlates of learned safety","volume":"39","author":"Kong","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1295","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0092-8674(00)81958-3","article-title":"Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome","volume":"98","author":"Kornberg","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1300","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1017\/S0033291710000930","article-title":"A randomized trial of sertraline, self-administered cognitive behavior therapy, and their combination for panic disorder","volume":"41","author":"Koszycki","year":"2011","journal-title":"Psychol Med"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1305","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","article-title":"Chromatin modifications and their function","volume":"128","author":"Kouzarides","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1310","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1152\/jn.00843.2004","article-title":"Dopamine modulates excitability of basolateral amygdala neurons in vitro","volume":"93","author":"Kroner","year":"2005","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1315","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.bbr.2013.05.002","article-title":"Involvement of cannabinoid receptors in the amygdala and prefrontal cortex of rats in fear learning, consolidation, retrieval and extinction","volume":"250","author":"Kuhnert","year":"2013","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1320","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00213-011-2353-x","article-title":"Effect of D-cycloserine and valproic acid on the extinction of reinstated fear-conditioned responses and habituation of fear conditioning in healthy humans: A randomized controlled trial","volume":"218","author":"Kuriyama","year":"2011","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1325","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.biopsych.2006.12.020","article-title":"D-cycloserine augmented exposure therapy for obsessive-compulsive disorder","volume":"62","author":"Kushner","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1330","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.beth.2012.11.001","article-title":"Preventing return of fear in an animal model of anxiety: Additive effects of massive extinction and extinction in multiple contexts","volume":"44","author":"Laborda","year":"2013","journal-title":"Behav Ther"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1335","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1038\/npp.2010.123","article-title":"Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder","volume":"35","author":"Labuschagne","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1340","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.nlm.2013.04.005","article-title":"Role of NPY Y1 receptor on acquisition, consolidation and extinction on contextual fear conditioning: Dissociation between anxiety, locomotion and non-emotional memory behavior","volume":"103","author":"Lach","year":"2013","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1345","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1016\/S0735-1097(00)00988-8","article-title":"Intracoronary basic fibroblast growth factor (FGF-2) in patients with severe ischemic heart disease: Results of a phase I open-label dose escalation study","volume":"36","author":"Laham","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1350","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1016\/j.psyneuen.2013.04.006","article-title":"Oxytocinergic manipulations in corticolimbic circuit differentially affect fear acquisition and extinction","volume":"38","author":"Lahoud","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1365","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1101\/lm.692407","article-title":"The effect of the NMDA receptor antagonist MK-801 on the acquisition and extinction of learned fear in the developing rat","volume":"14","author":"Langton","year":"2007","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1355","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1038\/npp.2008.32","article-title":"D-cycloserine facilitates extinction the first time but not the second time: An examination of the role of NMDA across the course of repeated extinction sessions","volume":"33","author":"Langton","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1360","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1101\/lm.1927310","article-title":"The effect of D-cycloserine on immediate vs. delayed extinction of learned fear","volume":"17","author":"Langton","year":"2010","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1375","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1037\/0735-7044.121.5.1125","article-title":"Systemic or intrahippocampal delivery of histone deacetylase inhibitors facilitates fear extinction","volume":"121","author":"Lattal","year":"2007","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1370","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.biopsych.2006.05.038","article-title":"Extinction: [corrected] does it or doesn't it? The requirement of altered gene activity and new protein synthesis","volume":"60","author":"Lattal","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1390","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1101\/lm.928208","article-title":"The basolateral amygdala is necessary for learning but not relearning extinction of context conditioned fear","volume":"15","author":"Laurent","year":"2008","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1380","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1101\/lm.1080108","article-title":"Distinct contributions of the basolateral amygdala and the medial prefrontal cortex to learning and relearning extinction of context conditioned fear","volume":"15","author":"Laurent","year":"2008","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1385","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1101\/lm.1474609","article-title":"Inactivation of the infralimbic but not the prelimbic cortex impairs consolidation and retrieval of fear extinction","volume":"16","author":"Laurent","year":"2009","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1395","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.nlm.2013.09.005","article-title":"Co-activation of NR2A and NR2B subunits induces resistance to fear extinction","volume":"113","author":"Leaderbrand","year":"2014","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1400","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.bbr.2013.07.024","article-title":"Sex differences and estrous cycle in female rats interact with the effects of fluoxetine treatment on fear extinction","volume":"253","author":"Lebron-Milad","year":"2013","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1405","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1037\/0735-7044.117.2.341","article-title":"Effects of D-cycloserine on extinction of conditioned freezing","volume":"117","author":"Ledgerwood","year":"2003","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1410","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1037\/0735-7044.118.3.505","article-title":"D-cycloserine and the facilitation of extinction of conditioned fear: Consequences for reinstatement","volume":"118","author":"Ledgerwood","year":"2004","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1415","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.biopsych.2005.01.023","article-title":"D-cycloserine facilitates extinction of learned fear: Effects on reacquisition and generalized extinction","volume":"57","author":"Ledgerwood","year":"2005","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1420","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1523\/JNEUROSCI.08-07-02517.1988","article-title":"Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear","volume":"8","author":"LeDoux","year":"1988","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1425","doi-asserted-by":"crossref","first-page":"8444","DOI":"10.1523\/JNEUROSCI.18-20-08444.1998","article-title":"Amygdalar NMDA receptors are critical for new fear learning in previously fear-conditioned rats","volume":"18","author":"Lee","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1430","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.brainres.2005.02.050","article-title":"Retrograde study of projections from the tuberomammillary nucleus to the dorsal raphe and the locus coeruleus in the rat","volume":"1043","author":"Lee","year":"2005","journal-title":"Brain Res"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1435","doi-asserted-by":"crossref","first-page":"10051","DOI":"10.1523\/JNEUROSCI.2466-06.2006","article-title":"Reconsolidation and extinction of conditioned fear: Inhibition and potentiation","volume":"26","author":"Lee","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1440","doi-asserted-by":"crossref","first-page":"35671","DOI":"10.1074\/jbc.M401923200","article-title":"Dopamine D1 and D2 receptor Co-activation generates a novel phospholipase C-mediated calcium signal","volume":"279","author":"Lee","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1445","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.nlm.2010.08.014","article-title":"The effects of midazolam and D-cycloserine on the release of glutamate and GABA in the basolateral amygdala of low and high anxiety rats during extinction trial of a conditioned fear test","volume":"94","author":"Lehner","year":"2010","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1450","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1152\/jn.00472.2010","article-title":"BDNF evokes release of endogenous cannabinoids at layer 2\/3 inhibitory synapses in the neocortex","volume":"104","author":"Lemtiri-Chlieh","year":"2010","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1455","doi-asserted-by":"crossref","first-page":"15763","DOI":"10.1074\/jbc.M511767200","article-title":"Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus","volume":"281","author":"Levenson","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1460","doi-asserted-by":"crossref","first-page":"e26065","DOI":"10.1371\/journal.pone.0026065","article-title":"Synergistic activation of dopamine D1 and TrkB receptors mediate gain control of synaptic plasticity in the basolateral amygdala","volume":"6","author":"Li","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1470","doi-asserted-by":"crossref","first-page":"7120","DOI":"10.1073\/pnas.1318906111","article-title":"Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation","volume":"111","author":"Li","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1465","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1037\/0097-7403.34.3.336","article-title":"Massed extinction trials produce better short-term but worse long-term loss of context conditioned fear responses than spaced trials","volume":"34","author":"Li","year":"2008","journal-title":"J Exp Psychol Anim Behav Process"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1475","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nature07167","article-title":"Amygdala intercalated neurons are required for expression of fear extinction","volume":"454","author":"Likhtik","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1480","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1124\/mol.63.1.44","article-title":"Involvement of a calcineurin cascade in amygdala depotentiation and quenching of fear memory","volume":"63","author":"Lin","year":"2003","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1490","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/cercor\/bhn075","article-title":"The role of prefrontal cortex CB1 receptors in the modulation of fear memory","volume":"19","author":"Lin","year":"2009","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1495","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1017\/S1461145709990678","article-title":"Alterations of excitatory transmission in the lateral amygdala during expression and extinction of fear memory","volume":"13","author":"Lin","year":"2010","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1500","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/nn.2891","article-title":"The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory","volume":"14","author":"Lin","year":"2011","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1485","doi-asserted-by":"crossref","first-page":"8310","DOI":"10.1523\/JNEUROSCI.23-23-08310.2003","article-title":"The similarities and diversities of signal pathways leading to consolidation of conditioning and consolidation of extinction of fear memory","volume":"23","author":"Lin","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1505","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.jpsychires.2012.05.006","article-title":"A randomized placebo-controlled trial of D-cycloserine and exposure therapy for posttraumatic stress disorder","volume":"46","author":"Litz","year":"2012","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1510","doi-asserted-by":"crossref","first-page":"e7548","DOI":"10.1371\/journal.pone.0007548","article-title":"A NMDA receptor antagonist, MK-801 impairs consolidating extinction of auditory conditioned fear responses in a Pavlovian model","volume":"4","author":"Liu","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1515","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1093\/cercor\/bhr220","article-title":"5-HT1A receptor agonists enhance pyramidal cell firing in prefrontal cortex through a preferential action on GABA interneurons","volume":"22","author":"Llado-Pelfort","year":"2012","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1520","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.neuropharm.2004.07.015","article-title":"Dopaminergic modulation of spontaneous inhibitory network activity in the lateral amygdala","volume":"47","author":"Loretan","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1525","doi-asserted-by":"crossref","first-page":"RC162","DOI":"10.1523\/JNEUROSCI.21-16-j0005.2001","article-title":"Mitogen-activated protein kinase cascade in the basolateral nucleus of amygdala is involved in extinction of fear-potentiated startle","volume":"21","author":"Lu","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1530","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.neuron.2007.07.039","article-title":"The IkappaB kinase regulates chromatin structure during reconsolidation of conditioned fear memories","volume":"55","author":"Lubin","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1535","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nrn1845","article-title":"Dendritic peptide release and peptide-dependent behaviours","volume":"7","author":"Ludwig","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1540","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neulet.2014.04.031","article-title":"Effect of nitric oxide synthase inhibitor l-NAME on fear extinction in rats: A task-dependent effect","volume":"572","author":"Luo","year":"2014","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1545","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1210\/me.2013-1314","article-title":"Minireview: More than just a hammer: Ligand \u201cbias\u201d and pharmaceutical discovery","volume":"28","author":"Luttrell","year":"2014","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1550","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3928\/00485713-20101123-03","article-title":"The role of benzodiazepines in the treatment of anxiety disorders: A clinical review","volume":"40","author":"Macaluso","year":"2010","journal-title":"Psychiatr Ann"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1555","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0304-3940(93)90437-P","article-title":"Glucocorticoid regulation of cannabinoid receptor messenger RNA levels in the rat caudate-putamen. An in situ hybridization study","volume":"156","author":"Mailleux","year":"1993","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1560","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neulet.2009.10.011","article-title":"BDNF regulates neuronal sensitivity to endocannabinoids","volume":"467","author":"Maison","year":"2009","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1565","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1038\/npp.2010.53","article-title":"Behavioral and neural analysis of GABA in the acquisition, consolidation, reconsolidation, and extinction of fear memory","volume":"35","author":"Makkar","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1570","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1073\/pnas.1213364110","article-title":"HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner","volume":"110","author":"Malvaez","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1575","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1113\/jphysiol.2010.201475","article-title":"Functional connectivity of the main intercalated nucleus of the mouse amygdala","volume":"589","author":"Manko","year":"2011","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1585","doi-asserted-by":"crossref","first-page":"e59580","DOI":"10.1371\/journal.pone.0059580","article-title":"Inhibition of spontaneous recovery of fear by mGluR5 after prolonged extinction training","volume":"8","author":"Mao","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1580","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1038\/npp.2008.30","article-title":"Augmentation of fear extinction by D-cycloserine is blocked by proteasome inhibitors","volume":"33","author":"Mao","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1590","doi-asserted-by":"crossref","first-page":"7486","DOI":"10.1523\/JNEUROSCI.0133-11.2011","article-title":"Paradoxical enhancement of fear extinction memory and synaptic plasticity by inhibition of the histone acetyltransferase p300","volume":"31","author":"Marek","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1595","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1146\/annurev.neuro.24.1.897","article-title":"Neurobiology of Pavlovian fear conditioning","volume":"24","author":"Maren","year":"2001","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1600","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nrn3492","article-title":"The contextual brain: Implications for fear conditioning, extinction and psychopathology","volume":"14","author":"Maren","year":"2013","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1605","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1192\/bjp.162.6.776","article-title":"Alprazolam and exposure alone and combined in panic disorder with agoraphobia. A controlled study in London and Toronto","volume":"162","author":"Marks","year":"1993","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1610","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nature00839","article-title":"The endogenous cannabinoid system controls extinction of aversive memories","volume":"418","author":"Marsicano","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1615","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1172\/JCI41356","article-title":"Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents","volume":"120","author":"Massa","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1620","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1192\/bjp.bp.113.126284","article-title":"Cognitive-behavioural therapy with post-session D-cycloserine augmentation for paediatric obsessive\u2013compulsive disorder: Pilot randomised controlled trial","volume":"204","author":"Mataix-Cols","year":"2014","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1625","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.pnpbp.2010.04.013","article-title":"d-serine enhances extinction of auditory cued fear conditioning via ERK1\/2 phosphorylation in mice","volume":"34","author":"Matsuda","year":"2010","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1635","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00213-013-3078-9","article-title":"Vorinostat ameliorates impaired fear extinction possibly via the hippocampal NMDA-CaMKII pathway in an animal model of posttraumatic stress disorder","volume":"229","author":"Matsumoto","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1630","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.pbb.2007.12.017","article-title":"Early postnatal stress alters the extinction of context-dependent conditioned fear in adult rats","volume":"89","author":"Matsumoto","year":"2008","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1640","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0304-3940(89)90659-9","article-title":"Coexistence of GABA and peptide immunoreactivity in non-pyramidal neurons of the basolateral amygdala","volume":"100","author":"McDonald","year":"1989","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1645","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1126\/science.287.5451.248","article-title":"Memory\u2013a century of consolidation","volume":"287","author":"McGaugh","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1650","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1037\/0735-7044.104.2.264","article-title":"Picrotoxin enhances latent extinction of conditioned fear","volume":"104","author":"McGaugh","year":"1990","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1655","first-page":"1","article-title":"Enhancing exposure therapy for anxiety disorders, obsessive-compulsive disorder and post-traumatic stress disorder","author":"McGuire","year":"2014","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1660","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1101\/lm.279006","article-title":"The L-Type voltage-gated calcium channel Cav1.3 mediates consolidation, but not extinction, of contextually conditioned fear in mice","volume":"13","author":"McKinney","year":"2006","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1670","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.nlm.2009.06.012","article-title":"Impaired long-term potentiation and enhanced neuronal excitability in the amygdala of Ca(V)1.3 knockout mice","volume":"92","author":"McKinney","year":"2009","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1665","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1101\/lm.893808","article-title":"L-type voltage-gated calcium channels in conditioned fear: A genetic and pharmacological analysis","volume":"15","author":"McKinney","year":"2008","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1675","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1037\/0735-7044.119.6.1672","article-title":"Facilitation of fear extinction by midbrain periaqueductal gray infusions of RB101(S), an inhibitor of enkephalin-degrading enzymes","volume":"119","author":"McNally","year":"2005","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1695","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1037\/0735-7044.119.4.1023","article-title":"The midbrain periaqueductal gray and fear extinction: Opioid receptor subtype and roles of cyclic AMP, protein kinase A, and mitogen-activated protein kinase","volume":"119","author":"McNally","year":"2005","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1690","doi-asserted-by":"crossref","first-page":"6912","DOI":"10.1523\/JNEUROSCI.1828-04.2004","article-title":"Opioid receptors in the midbrain periaqueductal gray regulate extinction of pavlovian fear conditioning","volume":"24","author":"McNally","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1680","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1037\/0735-7044.117.6.1292","article-title":"Opioid receptors regulate the extinction of Pavlovian fear conditioning","volume":"117","author":"McNally","year":"2003","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1685","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1101\/lm.196606","article-title":"Predicting danger: The nature, consequences, and neural mechanisms of predictive fear learning","volume":"13","author":"McNally","year":"2006","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1705","doi-asserted-by":"crossref","first-page":"e2695","DOI":"10.1371\/journal.pone.0002695","article-title":"Identification of a neuropeptide S responsive circuitry shaping amygdala activity via the endopiriform nucleus","volume":"3","author":"Meis","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1700","doi-asserted-by":"crossref","first-page":"e18020","DOI":"10.1371\/journal.pone.0018020","article-title":"Neuropeptide S-mediated facilitation of synaptic transmission enforces subthreshold theta oscillations within the lateral amygdala","volume":"6","author":"Meis","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1710","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/jts.21909","article-title":"Glasgow Coma Scores, early opioids, and posttraumatic stress disorder among combat amputees","volume":"27","author":"Melcer","year":"2014","journal-title":"J Trauma Stress"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1715","first-page":"343","article-title":"The effect of catecholamines on learning in rats","volume":"16","author":"Merlo","year":"1967","journal-title":"Med Pharmacol Exp Int J Exp Med"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1720","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1523\/JNEUROSCI.4001-13.2014","article-title":"Reconsolidation and extinction are dissociable and mutually exclusive processes: Behavioral and molecular evidence","volume":"34","author":"Merlo","year":"2014","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1730","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000329454","article-title":"Does yohimbine hydrochloride facilitate fear extinction in virtual reality treatment of fear of flying? A randomized placebo-controlled trial","volume":"81","author":"Meyerbroeker","year":"2012","journal-title":"Psychother Psychosom"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1725","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/nrn3044","article-title":"Oxytocin and vasopressin in the human brain: Social neuropeptides for translational medicine","volume":"12","author":"Meyer-Lindenberg","year":"2011","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1735","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1037\/0021-843X.116.3.612","article-title":"Fear conditioning in panic disorder: Enhanced resistance to extinction","volume":"116","author":"Michael","year":"2007","journal-title":"J Abnorm Psychol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1740","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.pbb.2013.02.019","article-title":"Chronic dietary magnesium-L-threonate speeds extinction and reduces spontaneous recovery of a conditioned taste aversion","volume":"106","author":"Mickley","year":"2013","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1750","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1001\/jamapsychiatry.2013.914","article-title":"Deficits in conditioned fear extinction in obsessive\u2013compulsive disorder and neurobiological changes in the fear circuit","volume":"70","author":"Milad","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1755","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.biopsych.2009.06.026","article-title":"Neurobiological basis of failure to recall extinction memory in posttraumatic stress disorder","volume":"66","author":"Milad","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1745","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev.psych.121208.131631","article-title":"Fear extinction as a model for translational neuroscience: Ten years of progress","volume":"63","author":"Milad","year":"2012","journal-title":"Annu Rev Psychol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1760","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1017\/S1461145712001496","article-title":"On \u2018polypharmacy\u2019 and multi-target agents, complementary strategies for improving the treatment of depression: A comparative appraisal","volume":"17","author":"Millan","year":"2014","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1765","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1523\/JNEUROSCI.3273-12.2013","article-title":"Double dissociation of the requirement for GluN2B- and GluN2A-containing NMDA receptors in the destabilization and restabilization of a reconsolidating memory","volume":"33","author":"Milton","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1770","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1177\/0269881110378371","article-title":"The safety and efficacy of {+\/\u2212}3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: The first randomized controlled pilot study","volume":"25","author":"Mithoefer","year":"2011","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1775","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1177\/0269881112456611","article-title":"Durability of improvement in post-traumatic stress disorder symptoms and absence of harmful effects or drug dependency after 3,4-methylenedioxymethamphetamine-assisted psychotherapy: A prospective long-term follow-up study","volume":"27","author":"Mithoefer","year":"2013","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1780","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0165-0173(01)00128-X","article-title":"Modulation of fibroblast growth factor-2 by stress and corticosteroids: From developmental events to adult brain plasticity","volume":"37","author":"Molteni","year":"2001","journal-title":"Brain Res Brain Res Rev"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1785","doi-asserted-by":"crossref","first-page":"5065","DOI":"10.2174\/1381612811319280005","article-title":"Histone post-translational modifications to target memory-related diseases","volume":"19","author":"Monti","year":"2013","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1790","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1242\/jeb.068213","article-title":"The effects of muscimol and AMN082 injections into the medial prefrontal cortex on the expression and extinction of conditioned fear in mice","volume":"215","author":"Morawska","year":"2012","journal-title":"J Exp Biol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1800","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1037\/0735-7044.121.3.501","article-title":"The effect of yohimbine on the extinction of conditioned fear: A role for context","volume":"121","author":"Morris","year":"2007","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1795","doi-asserted-by":"crossref","first-page":"6401","DOI":"10.1523\/JNEUROSCI.1001-12.2013","article-title":"Loss of histone deacetylase 2 improves working memory and accelerates extinction learning","volume":"33","author":"Morris","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1805","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0306-4522(99)00014-7","article-title":"The role of mesoprefrontal dopamine neurons in the acquisition and expression of conditioned fear in the rat","volume":"92","author":"Morrow","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1820","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.biopsych.2010.08.014","article-title":"Infralimbic D2 receptors are necessary for fear extinction and extinction-related tone responses","volume":"68","author":"Mueller","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1810","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2009.11.025","article-title":"Noradrenergic modulation of extinction learning and exposure therapy","volume":"208","author":"Mueller","year":"2010","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1825","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s00213-009-1491-x","article-title":"The effects of yohimbine and amphetamine on fear expression and extinction in rats","volume":"204","author":"Mueller","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1815","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1523\/JNEUROSCI.3248-07.2008","article-title":"Noradrenergic signaling in infralimbic cortex increases cell excitability and strengthens memory for fear extinction","volume":"28","author":"Mueller","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1830","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1111\/j.1460-9568.2008.06511.x","article-title":"Impaired extinction of learned fear in rats selectively bred for high anxiety\u2013evidence of altered neuronal processing in prefrontal-amygdala pathways","volume":"28","author":"Muigg","year":"2008","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1840","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/npp.2010.88","article-title":"Glutamate receptors in extinction and extinction-based therapies for psychiatric illness","volume":"36","author":"Myers","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1835","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/sj.mp.4001939","article-title":"Mechanisms of fear extinction","volume":"12","author":"Myers","year":"2007","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1845","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1037\/0735-7044.113.5.891","article-title":"Inhibition of the mesoamygdala dopaminergic pathway impairs the retrieval of conditioned fear associations","volume":"113","author":"Nader","year":"1999","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1850","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/35021052","article-title":"Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval","volume":"406","author":"Nader","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1855","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.4088\/JCP.11m07564","article-title":"Exposure therapy, D-cycloserine, and functional magnetic resonance imaging in patients with snake phobia: A randomized pilot study","volume":"73","author":"Nave","year":"2012","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1860","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1523\/JNEUROSCI.3796-07.2008","article-title":"Activity-dependent suppression of miniature neurotransmission through the regulation of DNA methylation","volume":"28","author":"Nelson","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1865","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.tins.2012.08.004","article-title":"Balance of brain oxytocin and vasopressin: Implications for anxiety, depression, and social behaviors","volume":"35","author":"Neumann","year":"2012","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1870","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/mp.2013.61","article-title":"Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: A positron emission tomography study","volume":"18","author":"Neumeister","year":"2013","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1875","doi-asserted-by":"crossref","first-page":"8866","DOI":"10.1523\/JNEUROSCI.1405-10.2010","article-title":"The BDNF Val66Met polymorphism impairs NMDA receptor-dependent synaptic plasticity in the hippocampus","volume":"30","author":"Ninan","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1880","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.pnpbp.2010.06.025","article-title":"Spironolactone and low-dose dexamethasone enhance extinction of contextual fear conditioning","volume":"34","author":"Ninomiya","year":"2010","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1885","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00213-006-0650-6","article-title":"The disruptive effects of the CB1 receptor antagonist rimonabant on extinction learning in mice are task-specific","volume":"191","author":"Niyuhire","year":"2007","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1890","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.biopsych.2008.01.012","article-title":"A meta-analysis of D-cycloserine and the facilitation of fear extinction and exposure therapy","volume":"63","author":"Norberg","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1895","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nature07238","article-title":"S-Nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons","volume":"455","author":"Nott","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1900","doi-asserted-by":"crossref","first-page":"28861","DOI":"10.1074\/jbc.M202927200","article-title":"Basic fibroblast growth factor evokes a rapid glutamate release through activation of the MAPK pathway in cultured cortical neurons","volume":"277","author":"Numakawa","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1905","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1177\/0269881113504017","article-title":"The role of the opioid system in alcohol dependence","volume":"28","author":"Nutt","year":"2014","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1910","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1192\/bjp.167.3.374","article-title":"Paroxetine in the treatment of panic disorder. A randomised, double-blind, placebo-controlled study","volume":"167","author":"Oehrberg","year":"1995","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1915","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/npp.2013.241","article-title":"Potentiation of GluN2C\/D NMDA receptor subtypes in the amygdala facilitates the retention of fear and extinction learning in mice","volume":"39","author":"Ogden","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1920","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.drudis.2011.01.001","article-title":"Phenothiazine: The seven lives of pharmacology's first lead structure","volume":"16","author":"Ohlow","year":"2011","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1925","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/890","article-title":"Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases","volume":"19","author":"Okano","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1930","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/j.neubiorev.2011.12.014","article-title":"Neural and cellular mechanisms of fear and extinction memory formation","volume":"36","author":"Orsini","year":"2012","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1935","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2174\/1381612023396726","article-title":"Benzodiazepine discontinuation difficulties in panic disorder: Conceptual model and outcome for cognitive-behavior therapy","volume":"8","author":"Otto","year":"2002","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1940","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/clipsy.bpi009","article-title":"Combined pharmacotherapy and cognitive-behavioral therapy for anxiety disorders: Medication effects, glucocorticoids, and attenuated treatment outcomes","volume":"12","author":"Otto","year":"2010","journal-title":"Clin Psychol Sci Pract"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1945","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.brat.2010.04.002","article-title":"Efficacy of CBT for benzodiazepine discontinuation in patients with panic disorder: Further evaluation","volume":"48","author":"Otto","year":"2010","journal-title":"Behav Res Ther"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1950","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.biopsych.2009.07.036","article-title":"Efficacy of d-cycloserine for enhancing response to cognitive-behavior therapy for panic disorder","volume":"67","author":"Otto","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1955","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/S0022-3565(24)37161-7","article-title":"Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites","volume":"283","author":"Owens","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1960","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.jpsychires.2012.04.015","article-title":"Sleep promotes consolidation and generalization of extinction learning in simulated exposure therapy for spider fear","volume":"46","author":"Pace-Schott","year":"2012","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1965","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.nlm.2008.04.003","article-title":"Short- and long-term effects of cannabinoids on the extinction of contextual fear memory in rats","volume":"90","author":"Pamplona","year":"2008","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1970","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s00213-006-0514-0","article-title":"The cannabinoid receptor agonist WIN 55,212-2 facilitates the extinction of contextual fear memory and spatial memory in rats","volume":"188","author":"Pamplona","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1975","doi-asserted-by":"crossref","first-page":"5711","DOI":"10.1523\/JNEUROSCI.17-15-05711.1997","article-title":"High-affinity zinc inhibition of NMDA NR1-NR2A receptors","volume":"17","author":"Paoletti","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1980","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrn3504","article-title":"NMDA receptor subunit diversity: Impact on receptor properties, synaptic plasticity and disease","volume":"14","author":"Paoletti","year":"2013","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1985","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.euroneuro.2010.05.005","article-title":"GABAergic control of novelty stress-responsive epigenetic and gene expression mechanisms in the rat dentate gyrus","volume":"21","author":"Papadopoulos","year":"2011","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1995","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuropharm.2009.06.001","article-title":"Neuropeptide S: A transmitter system in the brain regulating fear and anxiety","volume":"58","author":"Pape","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb1990","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1152\/physrev.00037.2009","article-title":"Plastic synaptic networks of the amygdala for the acquisition, expression, and extinction of conditioned fear","volume":"90","author":"Pape","year":"2010","journal-title":"Physiol Rev"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2000","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1515\/revneuro-2012-0052","article-title":"Contribution of serotonin type 3 receptors in the successful extinction of cued or contextual fear conditioned responses: Interactions with GABAergic signaling","volume":"23","author":"Park","year":"2012","journal-title":"Rev Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2005","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1046\/j.1460-9568.1999.00553.x","article-title":"Regional distribution of Y-receptor subtype mRNAs in rat brain","volume":"11","author":"Parker","year":"1999","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2010","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.nlm.2005.01.001","article-title":"Effects of multiple exposures to D-cycloserine on extinction of conditioned fear in rats","volume":"83","author":"Parnas","year":"2005","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2020","article-title":"Regulation of extinction-related plasticity by opioid receptors in the ventrolateral periaqueductal gray matter","volume":"4","author":"Parsons","year":"2010","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2015","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nn.3296","article-title":"Implications of memory modulation for post-traumatic stress and fear disorders","volume":"16","author":"Parsons","year":"2013","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2025","series-title":"Conditioned Reflexes","author":"Pavlov","year":"1927"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2030","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1146\/annurev.psych.52.1.111","article-title":"Theories of associative learning in animals","volume":"52","author":"Pearce","year":"2001","journal-title":"Annu Rev Psychol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2035","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1037\/0735-7044.103.1.202","article-title":"Inhibition by diazepam of the effect of additional training and of extinction on the retention of shuttle avoidance behavior in rats","volume":"103","author":"Pereira","year":"1989","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2040","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.neuroscience.2011.10.045","article-title":"Distribution of dopamine D(2)-like receptors in the rat amygdala and their role in the modulation of unconditioned fear and anxiety","volume":"201","author":"Perez de la Mora","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2045","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1126\/science.275.5299.523","article-title":"Regulation of NF-kappaB by cyclin-dependent kinases associated with the p300 coactivator","volume":"275","author":"Perkins","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2050","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1126\/science.1186909","article-title":"Induction of fear extinction with hippocampal-infralimbic BDNF","volume":"328","author":"Peters","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2055","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1097\/01.wnr.0000220142.29413.6f","article-title":"Prefrontal dopamine D4 receptors are involved in encoding fear extinction","volume":"17","author":"Pfeiffer","year":"2006","journal-title":"Neuroreport"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2060","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.neuroscience.2008.09.043","article-title":"Dopaminergic innervation of interneurons in the rat basolateral amygdala","volume":"157","author":"Pinard","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2065","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3389\/fncel.2014.00256","article-title":"Ganaxolone improves behavioral deficits in a mouse model of post-traumatic stress disorder","volume":"8","author":"Pinna","year":"2014","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2070","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00429-008-0180-6","article-title":"Ultrastructural analysis of prefrontal cortical inputs to the rat amygdala: Spatial relationships to presumed dopamine axons and D1 and D2 receptors","volume":"213","author":"Pinto","year":"2008","journal-title":"Brain Struct Funct"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2075","doi-asserted-by":"crossref","first-page":"4990","DOI":"10.1523\/JNEUROSCI.6038-09.2010","article-title":"Dissociation of within- and between-session extinction of conditioned fear","volume":"30","author":"Plendl","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2080","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1101\/lm.96605","article-title":"Systemic blockade of D2-like dopamine receptors facilitates extinction of conditioned fear in mice","volume":"12","author":"Ponnusamy","year":"2005","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2085","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nrn3138","article-title":"The stressed synapse: The impact of stress and glucocorticoids on glutamate transmission","volume":"13","author":"Popoli","year":"2012","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2090","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.euroneuro.2014.04.002","article-title":"Combination of fluoxetine and extinction treatments forms a unique synaptic protein profile that correlates with long-term fear reduction in adult mice","volume":"24","author":"Popova","year":"2014","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2095","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.janxdis.2009.01.001","article-title":"Facilitation of fear extinction in phobic participants with a novel cognitive enhancer: A randomized placebo controlled trial of yohimbine augmentation","volume":"23","author":"Powers","year":"2009","journal-title":"J Anxiety Disord"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2100","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.nlm.2013.03.003","article-title":"Impaired fear extinction learning in adult heterozygous BDNF knock-out mice","volume":"103","author":"Psotta","year":"2013","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2105","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0014-2999(94)90687-4","article-title":"Acute but not chronic activation of the NMDA-coupled glycine receptor with D-cycloserine facilitates learning and retention","volume":"257","author":"Quartermain","year":"1994","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2110","doi-asserted-by":"crossref","first-page":"14048","DOI":"10.1073\/pnas.94.25.14048","article-title":"Glucocorticoid enhancement of memory storage involves noradrenergic activation in the basolateral amygdala","volume":"94","author":"Quirarte","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2115","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.psyneuen.2010.12.005","article-title":"Oxytocin buffers cortisol responses to stress in individuals with impaired emotion regulation abilities","volume":"36","author":"Quirin","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2120","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.neuropharm.2012.06.063","article-title":"Cannabinoid facilitation of fear extinction memory recall in humans","volume":"64","author":"Rabinak","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2125","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.physbeh.2010.01.040","article-title":"Alterations in fear response and spatial memory in pre- and post-natal zinc supplemented rats: Remediation by copper","volume":"100","author":"Railey","year":"2010","journal-title":"Physiol Behav"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2130","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1152\/jn.1999.82.1.69","article-title":"Serotonergic modulation of neurotransmission in the rat basolateral amygdala","volume":"82","author":"Rainnie","year":"1999","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2135","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1177\/0269881107083999","article-title":"Endocannabinoid modulation of fear responses: Learning and state-dependent performance effects","volume":"22","author":"Reich","year":"2008","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2140","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1098\/rstb.2006.1894","article-title":"Neurotrophin-regulated signalling pathways","volume":"361","author":"Reichardt","year":"2006","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2145","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.pnpbp.2013.02.017","article-title":"The effects of intra-hippocampal microinfusion of D-cycloserine on fear extinction, and the expression of NMDA receptor subunit NR2B and neurogenesis in the hippocampus in rats","volume":"44","author":"Ren","year":"2013","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2150","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1001\/archpsyc.61.11.1136","article-title":"Cognitive enhancers as adjuncts to psychotherapy: Use of D-cycloserine in phobic individuals to facilitate extinction of fear","volume":"61","author":"Ressler","year":"2004","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2155","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fpsyt.2014.00005","article-title":"Making memories of stressful events: A journey along epigenetic, gene transcription, and signaling pathways","volume":"5","author":"Reul","year":"2014","journal-title":"Front Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2160","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/npp.2013.338","article-title":"Dopamine D1 receptor activation rescues extinction impairments in low-estrogen female rats and induces cortical layer-specific activation changes in prefrontal-amygdala circuits","volume":"39","author":"Rey","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2165","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.pbb.2011.04.010","article-title":"New perspectives in glutamate and anxiety","volume":"100","author":"Riaza Bermudo-Soriano","year":"2012","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2170","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.neuroscience.2011.11.057","article-title":"Fear relief-toward a new conceptual frame work and what endocannabinoids gotta do with it","volume":"204","author":"Riebe","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2180","doi-asserted-by":"crossref","first-page":"5219","DOI":"10.1523\/JNEUROSCI.22-12-05219.2002","article-title":"The group I metabotropic glutamate receptor mGluR5 is required for fear memory formation and long-term potentiation in the lateral amygdala","volume":"22","author":"Rodrigues","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2175","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jad.2010.08.025","article-title":"CBT for pharmacotherapy non-remitters\u2014A systematic review of a next-step strategy","volume":"129","author":"Rodrigues","year":"2011","journal-title":"J Affect Disord"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2185","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.biopsych.2009.01.009","article-title":"Systemic propranolol acts centrally to reduce conditioned fear in rats without impairing extinction","volume":"65","author":"Rodriguez-Romaguera","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2190","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.neuron.2005.02.017","article-title":"Distinct neural signatures for safety and danger in the amygdala and striatum of the mouse","volume":"46","author":"Rogan","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2195","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.pneurobio.2011.10.007","article-title":"Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue","volume":"96","author":"Rojas","year":"2012","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2200","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1046\/j.0953-816x.2001.01876.x","article-title":"Glucocorticoids interact with the basolateral amygdala beta-adrenoceptor\u2013cAMP\/cAMP\/PKA system in influencing memory consolidation","volume":"15","author":"Roozendaal","year":"2002","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2205","doi-asserted-by":"crossref","first-page":"6642","DOI":"10.1523\/JNEUROSCI.1336-08.2008","article-title":"Corticotropin-releasing factor in the basolateral amygdala enhances memory consolidation via an interaction with the beta-adrenoceptor-cAMP pathway: Dependence on glucocorticoid receptor activation","volume":"28","author":"Roozendaal","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2215","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1038\/npp.2014.64","article-title":"Hippocampal-prefrontal BDNF and memory for fear extinction","volume":"39","author":"Rosas-Vidal","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2220","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0005-7967(97)10016-X","article-title":"Effects of an expanding-spaced vs massed exposure schedule on fear reduction and return of fear","volume":"36","author":"Rowe","year":"1998","journal-title":"Behav Res Ther"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2225","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0005-7967(97)10017-1","article-title":"Effects of varied-stimulus exposure training on fear reduction and return of fear","volume":"36","author":"Rowe","year":"1998","journal-title":"Behav Res Ther"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2230","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.neuron.2013.08.003","article-title":"Tet1 is critical for neuronal activity-regulated gene expression and memory extinction","volume":"79","author":"Rudenko","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2235","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/nrm2298","article-title":"Multivalent engagement of chromatin modifications by linked binding modules","volume":"8","author":"Ruthenburg","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2240","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/syn.21621","article-title":"Facilitation of fear extinction by the 5-HT(1A) receptor agonist tandospirone: Possible involvement of dopaminergic modulation","volume":"67","author":"Saito","year":"2013","journal-title":"Synapse"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2245","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/s00213-005-0247-5","article-title":"5-HT receptor subtypes involved in the anxiogenic-like action and associated Fos response of acute fluoxetine treatment in rats","volume":"185","author":"Salchner","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2250","doi-asserted-by":"crossref","first-page":"15713","DOI":"10.1523\/JNEUROSCI.2620-09.2009","article-title":"Deficiency of the 65 kDa isoform of glutamic acid decarboxylase impairs extinction of cued but not contextual fear memory","volume":"29","author":"Sangha","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2255","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1093\/cercor\/bhh070","article-title":"Expression of serotonin1A and serotonin2A receptors in pyramidal and GABAergic neurons of the rat prefrontal cortex","volume":"14","author":"Santana","year":"2004","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2260","doi-asserted-by":"crossref","first-page":"9009","DOI":"10.1523\/JNEUROSCI.21-22-09009.2001","article-title":"Consolidation of extinction learning involves transfer from NMDA-independent to NMDA-dependent memory","volume":"21","author":"Santini","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2265","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1089\/cap.2013.0106","article-title":"Randomized placebo-controlled D-cycloserine with cognitive behavior therapy for pediatric posttraumatic stress","volume":"24","author":"Scheeringa","year":"2014","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2275","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1101\/lm.909208","article-title":"Evidence for recovery of fear following immediate extinction in rats and humans","volume":"15","author":"Schiller","year":"2008","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2270","first-page":"e3893","article-title":"Extinction training during the reconsolidation window prevents recovery of fear","author":"Schiller","year":"2012","journal-title":"J Vis Exp"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2280","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1176\/appi.ajp.2011.11020321","article-title":"Combined prolonged exposure therapy and paroxetine for PTSD related to the World Trade Center attack: A randomized controlled trial","volume":"169","author":"Schneier","year":"2012","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2285","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/ng.2695","article-title":"Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism","volume":"45","author":"Scholl","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2290","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.biopsych.2014.03.008","article-title":"Reconsolidation of human memory: Brain mechanisms and clinical relevance","volume":"76","author":"Schwabe","year":"2014","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2295","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.pharmthera.2009.05.006","article-title":"30 years of dynorphins\u2014New insights on their functions in neuropsychiatric diseases","volume":"123","author":"Schwarzer","year":"2009","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2300","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.neuron.2013.11.006","article-title":"Long-range connectivity defines behavioral specificity of amygdala neurons","volume":"81","author":"Senn","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2305","doi-asserted-by":"crossref","first-page":"7184","DOI":"10.1523\/JNEUROSCI.5198-12.2013","article-title":"Fear extinction induces mGluR5-mediated synaptic and intrinsic plasticity in infralimbic neurons","volume":"33","author":"Sepulveda-Orengo","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2310","first-page":"150","article-title":"Global measures of outcome in a controlled comparison of pharmacological and psychological treatment of panic disorder and agoraphobia in primary care","volume":"47","author":"Sharp","year":"1997","journal-title":"Br J Gen Pract"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2315","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1111\/j.1471-4159.2011.07387.x","article-title":"L-type voltage-dependent calcium channels facilitate acetylation of histone H3 through PKCgamma phosphorylation in mice with methamphetamine-induced place preference","volume":"118","author":"Shibasaki","year":"2011","journal-title":"J Neurochem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2320","doi-asserted-by":"crossref","first-page":"e74668","DOI":"10.1371\/journal.pone.0074668","article-title":"Nitric oxide signaling exerts bidirectional effects on plasticity inductions in amygdala","volume":"8","author":"Shin","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2325","doi-asserted-by":"crossref","first-page":"6476","DOI":"10.1523\/JNEUROSCI.16-20-06476.1996","article-title":"Basic fibroblast growth factor increases functional L-type Ca2+ channels in fetal rat hippocampal neurons: Implications for neurite morphogenesis in vitro","volume":"16","author":"Shitaka","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2330","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1471-4159.2010.06947.x","article-title":"Neuropeptide S stimulates dopaminergic neurotransmission in the medial prefrontal cortex","volume":"115","author":"Si","year":"2010","journal-title":"J Neurochem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2335","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1097\/WNR.0b013e328307f295","article-title":"Amygdaloid metabotropic glutamate receptor subtype 7 is involved in the acquisition of conditioned fear","volume":"19","author":"Siegl","year":"2008","journal-title":"Neuroreport"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2340","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.jpsychires.2011.01.020","article-title":"D-cycloserine does not improve but might slightly speed up the outcome of in-vivo exposure therapy in patients with severe agoraphobia and panic disorder in a randomized double blind clinical trial","volume":"45","author":"Siegmund","year":"2011","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2345","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/npp.2010.184","article-title":"Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear","volume":"36","author":"Sierra-Mercado","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2350","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0091-6773(73)80050-1","article-title":"Extinction of a passive avoidance response in adrenalectomized and demedullated rats","volume":"9","author":"Silva","year":"1973","journal-title":"Behav Biol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2355","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.physbeh.2007.08.020","article-title":"Effects of REM deprivation and an NMDA agonist on the extinction of conditioned fear","volume":"93","author":"Silvestri","year":"2008","journal-title":"Physiol Behav"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2360","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0301-0082(98)00039-2","article-title":"Release of neurotransmitters in the locus coeruleus","volume":"56","author":"Singewald","year":"1998","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2365","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0006-3223(02)01574-3","article-title":"Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs","volume":"53","author":"Singewald","year":"2003","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2370","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1172\/JCI20208","article-title":"Isoform-specific regulation of mood behavior and pancreatic beta cell and cardiovascular function by L-type Ca 2+ channels","volume":"113","author":"Sinnegger-Brauns","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2375","article-title":"Selective breeding for high anxiety introduces a synonymous SNP that increases neuropeptide S receptor activity","author":"Slattery","year":"2014","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2390","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1037\/a0034120","article-title":"D-cycloserine augmentation of cognitive behavioral group therapy of social anxiety disorder: Prognostic and prescriptive variables","volume":"81","author":"Smits","year":"2013","journal-title":"J Consult Clin Psychol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2395","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.biopsych.2013.10.008","article-title":"Yohimbine enhancement of exposure therapy for social anxiety disorder: A randomized controlled trial","volume":"75","author":"Smits","year":"2014","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2385","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.jpsychires.2013.06.020","article-title":"D-cycloserine enhancement of exposure therapy for social anxiety disorder depends on the success of exposure sessions","volume":"47","author":"Smits","year":"2013","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2380","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.biopsych.2012.12.009","article-title":"D-cycloserine enhancement of fear extinction is specific to successful exposure sessions: Evidence from the treatment of height phobia","volume":"73","author":"Smits","year":"2013","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2400","doi-asserted-by":"crossref","first-page":"10297","DOI":"10.1523\/JNEUROSCI.18-24-10297.1998","article-title":"A dopamine\/D1 receptor\/protein kinase A\/dopamine- and cAMP-regulated phosphoprotein (Mr 32 kDa)\/protein phosphatase-1 pathway regulates dephosphorylation of the NMDA receptor","volume":"18","author":"Snyder","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2405","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1126\/science.1181886","article-title":"A genetic variant BDNF polymorphism alters extinction learning in both mouse and human","volume":"327","author":"Soliman","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2410","doi-asserted-by":"crossref","first-page":"5585","DOI":"10.1073\/pnas.0509184103","article-title":"Glucocorticoids reduce phobic fear in humans","volume":"103","author":"Soravia","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2415","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/da.22219","article-title":"Glucocorticoids enhance in vivo exposure-based therapy of spider phobia","volume":"31","author":"Soravia","year":"2014","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2420","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1038\/sj.npp.1301316","article-title":"Acquisition of fear extinction requires activation of NR2B-containing NMDA receptors in the lateral amygdala","volume":"32","author":"Sotres-Bayon","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2425","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1093\/cercor\/bhn099","article-title":"Dissociable roles for the ventromedial prefrontal cortex and amygdala in fear extinction: NR2B contribution","volume":"19","author":"Sotres-Bayon","year":"2009","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2430","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3389\/fgene.2012.00132","article-title":"Emerging role of non-coding RNA in neural plasticity, cognitive function, and neuropsychiatric disorders","volume":"3","author":"Spadaro","year":"2012","journal-title":"Front Genet"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2435","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.biopsych.2011.12.012","article-title":"Increasing histone acetylation in the hippocampus-infralimbic network enhances fear extinction","volume":"72","author":"Stafford","year":"2012","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2440","first-page":"25","article-title":"Pharmacotherapy of posttraumatic stress disorder: A review of meta-analyses and treatment guidelines","volume":"14","author":"Stein","year":"2009","journal-title":"CNS Spectr"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2445","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0165-1781(00)00154-2","article-title":"Do selective serotonin re-uptake inhibitors enhance the efficacy of very brief cognitive behavioral therapy for panic disorder? A pilot study","volume":"94","author":"Stein","year":"2000","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2455","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/YIC.0b013e32819f8480","article-title":"D-cycloserine does not enhance exposure-response prevention therapy in obsessive\u2013compulsive disorder","volume":"22","author":"Storch","year":"2007","journal-title":"Int Clin Psychopharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2450","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.biopsych.2010.07.015","article-title":"A preliminary study of D-cycloserine augmentation of cognitive-behavioral therapy in pediatric obsessive\u2013compulsive disorder","volume":"68","author":"Storch","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2460","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.nlm.2009.12.011","article-title":"US habituation, like CS extinction, produces a decrement in conditioned fear responding that is NMDA dependent and subject to renewal and reinstatement","volume":"93","author":"Storsve","year":"2010","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2470","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1042\/BST0340903","article-title":"Role of voltage-gated L-type Ca2+ channel isoforms for brain function","volume":"34","author":"Striessnig","year":"2006","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2465","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/wmts.102","article-title":"L-type Ca channels in heart and brain","volume":"3","author":"Striessnig","year":"2014","journal-title":"Wiley Interdiscip Rev Membr Transp Signal"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2475","doi-asserted-by":"crossref","first-page":"RC8","DOI":"10.1523\/JNEUROSCI.19-11-j0005.1999","article-title":"GABAergic antagonists block the inhibitory effects of serotonin in the lateral amygdala: A mechanism for modulation of sensory inputs related to fear conditioning","volume":"19","author":"Stutzmann","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2480","doi-asserted-by":"crossref","first-page":"13858","DOI":"10.1074\/jbc.M010610200","article-title":"Basic fibroblast growth factor-induced activation of novel CREB kinase during the differentiation of immortalized hippocampal cells","volume":"276","author":"Sung","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2485","first-page":"274","article-title":"Effects of exogenous glucocorticoid on combat-related PTSD symptoms","volume":"22","author":"Suris","year":"2010","journal-title":"Ann Clin Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2490","doi-asserted-by":"crossref","first-page":"4787","DOI":"10.1523\/JNEUROSCI.5491-03.2004","article-title":"Memory reconsolidation and extinction have distinct temporal and biochemical signatures","volume":"24","author":"Suzuki","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2495","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.biopsych.2008.09.002","article-title":"Experience-dependent epigenetic modifications in the central nervous system","volume":"65","author":"Sweatt","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2500","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bbr.2013.07.035","article-title":"GABAB receptor ligands do not modify conditioned fear responses in BALB\/c mice","volume":"256","author":"Sweeney","year":"2013","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2505","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/hipo.10043","article-title":"The role of NMDA glutamate receptors, PKA, MAPK, and CAMKII in the hippocampus in extinction of conditioned fear","volume":"13","author":"Szapiro","year":"2003","journal-title":"Hippocampus"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2510","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.pbb.2012.10.013","article-title":"Morphine prevents the development of stress-enhanced fear learning","volume":"103","author":"Szczytkowski-Thomson","year":"2013","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2515","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1126\/science.1170116","article-title":"Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1","volume":"324","author":"Tahiliani","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2520","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fnagi.2014.00026","article-title":"Cognitive decline due to excess synaptic Zn(2+) signaling in the hippocampus","volume":"6","author":"Takeda","year":"2014","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2525","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/43432","article-title":"Genetic enhancement of learning and memory in mice","volume":"401","author":"Tang","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2530","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jpsychires.2012.09.024","article-title":"Augmentation of exposure therapy with post-session administration of D-cycloserine","volume":"47","author":"Tart","year":"2013","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2535","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neuroscience.2011.03.051","article-title":"Altered GABA transmission in a mouse model of increased trait anxiety","volume":"183","author":"Tasan","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2540","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1176\/appi.ajp.2014.13101407","article-title":"Effects of post-session administration of methylene blue on fear extinction and contextual memory in adults with claustrophobia","volume":"171","author":"Telch","year":"2014","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2545","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/j.1460-9568.1990.tb00009.x","article-title":"Fibroblast growth factor enhances long-term potentiation in the hippocampal slice","volume":"2","author":"Terlau","year":"1990","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2550","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3389\/fnbeh.2011.00049","article-title":"The dopamine and cannabinoid interaction in the modulation of emotions and cognition: Assessing the role of cannabinoid CB1 receptor in neurons expressing dopamine D1 receptors","volume":"5","author":"Terzian","year":"2011","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2555","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1101\/lm.1920810","article-title":"Activation of the infralimbic cortex in a fear context enhances extinction learning","volume":"17","author":"Thompson","year":"2010","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2565","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1111\/j.1471-4159.2009.06058.x","article-title":"Dynamic chromatin remodeling events in hippocampal neurons are associated with NMDA receptor-mediated activation of Bdnf gene promoter 1","volume":"109","author":"Tian","year":"2009","journal-title":"J Neurochem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2560","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s00726-009-0315-y","article-title":"NMDA receptor activation induces differential epigenetic modification of Bdnf promoters in hippocampal neurons","volume":"38","author":"Tian","year":"2010","journal-title":"Amino Acids"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2570","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s11055-007-0044-1","article-title":"Effects of activation and blockade of NMDA receptors on the extinction of a conditioned passive avoidance response in mice with different levels of anxiety","volume":"37","author":"Tomilenko","year":"2007","journal-title":"Neurosci Behav Physiol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2580","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.neuropharm.2011.10.021","article-title":"Pharmacological interference with metabotropic glutamate receptor subtype 7 but not subtype 5 differentially affects within- and between-session extinction of Pavlovian conditioned fear","volume":"62","author":"Toth","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2575","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00213-012-2702-4","article-title":"Central administration of oxytocin receptor ligands affects cued fear extinction in rats and mice in a timepoint-dependent manner","volume":"223","author":"Toth","year":"2012","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2585","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.tins.2011.10.003","article-title":"Fear conditioning and extinction: Emotional states encoded by distinct signaling pathways","volume":"35","author":"Tronson","year":"2012","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2590","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.neuron.2013.07.047","article-title":"Fear extinction causes target-specific remodeling of perisomatic inhibitory synapses","volume":"80","author":"Trouche","year":"2013","journal-title":"Neuron"},{"issue":"Pt 3","key":"10.1016\/j.pharmthera.2014.12.004_bb2595","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1093\/brain\/114.3.1429","article-title":"D1\/D2 dopamine receptor stimulation by L-dopa. A [14C]-2-deoxyglucose autoradiographic study","volume":"114","author":"Trugman","year":"1991","journal-title":"Brain"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2600","doi-asserted-by":"crossref","first-page":"853","DOI":"10.15252\/embr.201438913","article-title":"On the resilience of remote traumatic memories against exposure therapy-mediated attenuation","volume":"15","author":"Tsai","year":"2014","journal-title":"EMBO Rep"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2605","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nn1659","article-title":"Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action","volume":"9","author":"Tsankova","year":"2006","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2610","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/(SICI)1096-9861(19970707)383:3<305::AID-CNE3>3.0.CO;2-7","article-title":"Distribution of oxytocin- and vasopressin-binding sites in the rat extended amygdala: A histoautoradiographic study","volume":"383","author":"Veinante","year":"1997","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2615","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1111\/j.1476-5381.2012.01872.x","article-title":"NPY controls fear conditioning and fear extinction by combined action on Y(1) and Y(2) receptors","volume":"166","author":"Verma","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2620","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.actpsy.2007.07.001","article-title":"Learning and memory in conditioned fear extinction: Effects of D-cycloserine","volume":"127","author":"Vervliet","year":"2008","journal-title":"Acta Psychol (Amst)"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2625","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.biopsycho.2012.01.006","article-title":"Extinction, generalization, and return of fear: A critical review of renewal research in humans","volume":"92","author":"Vervliet","year":"2013","journal-title":"Biol Psychol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2630","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1126\/science.1201043","article-title":"Oxytocin selectively gates fear responses through distinct outputs from the central amygdala","volume":"333","author":"Viviani","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2635","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1523\/JNEUROSCI.22-06-02343.2002","article-title":"Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats","volume":"22","author":"Walker","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2640","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1101\/lm.808608","article-title":"Selective and protracted effect of nifedipine on fear memory extinction correlates with induced stress response","volume":"15","author":"Waltereit","year":"2008","journal-title":"Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2645","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1017\/S1461145713000473","article-title":"5-HT1A-receptor agonist modified amygdala activity and amygdala-associated social behavior in a valproate-induced rat autism model","volume":"16","author":"Wang","year":"2013","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2650","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.nlm.2006.12.010","article-title":"Effects of D-cycloserine on extinction of learned fear to an olfactory cue","volume":"87","author":"Weber","year":"2007","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2655","doi-asserted-by":"crossref","first-page":"11930","DOI":"10.1523\/JNEUROSCI.0178-12.2012","article-title":"p300\/CBP-Associated Factor Selectively Regulates the Extinction of Conditioned Fear","volume":"32","author":"Wei","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2660","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1073\/pnas.88.5.1859","article-title":"D1 and D2 dopamine receptor mRNA in rat brain","volume":"88","author":"Weiner","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2665","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1523\/JNEUROSCI.4595-06.2007","article-title":"Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice","volume":"27","author":"Wellman","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2670","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.biopsych.2007.04.010","article-title":"Effects of D-cycloserine on extinction: Consequences of prior exposure to imipramine","volume":"62","author":"Werner-Seidler","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2675","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1176\/appi.ajp.2007.07030525","article-title":"Failure of extinction of fear responses in posttraumatic stress disorder: Evidence from second-order conditioning","volume":"164","author":"Wessa","year":"2007","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2685","doi-asserted-by":"crossref","first-page":"13586","DOI":"10.1523\/JNEUROSCI.0849-10.2010","article-title":"Rescue of impaired fear extinction and normalization of cortico-amygdala circuit dysfunction in a genetic mouse model by dietary zinc restriction","volume":"30","author":"Whittle","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2690","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.neuropharm.2012.06.001","article-title":"Deep brain stimulation, histone deacetylase inhibitors and glutamatergic drugs rescue resistance to fear extinction in a genetic mouse model","volume":"64","author":"Whittle","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2680","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1042\/BST20130233","article-title":"HDAC inhibitors as cognitive enhancers in fear, anxiety and trauma therapy: Where do we stand?","volume":"42","author":"Whittle","year":"2014","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2700","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1176\/appi.ajp.2007.07050776","article-title":"Augmentation of behavior therapy with D-cycloserine for obsessive\u2013compulsive disorder","volume":"165","author":"Wilhelm","year":"2008","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2695","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0005-7967(97)00033-8","article-title":"Acute and delayed effects of alprazolam on flight phobics during exposure","volume":"35","author":"Wilhelm","year":"1997","journal-title":"Behav Res Ther"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2705","doi-asserted-by":"crossref","first-page":"948","DOI":"10.7150\/ijbs.6426","article-title":"Glutamate, glutamate receptors, and downstream signaling pathways","volume":"9","author":"Willard","year":"2013","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2710","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1210\/endo.138.7.5255","article-title":"Central oxytocin administration reduces stress-induced corticosterone release and anxiety behavior in rats","volume":"138","author":"Windle","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2715","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.euroneuro.2011.07.018","article-title":"The size and burden of mental disorders and other disorders of the brain in Europe 2010","volume":"21","author":"Wittchen","year":"2011","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2720","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1037\/0735-7044.120.5.1159","article-title":"D-cycloserine facilitates extinction but does not eliminate renewal of the conditioned emotional response","volume":"120","author":"Woods","year":"2006","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2725","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.nlm.2006.08.009","article-title":"Methylene blue facilitates the extinction of fear in an animal model of susceptibility to learned helplessness","volume":"87","author":"Wrubel","year":"2007","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2730","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1602\/neurorx.2.1.120","article-title":"Neuroprotection in experimental stroke with targeted neurotrophins","volume":"2","author":"Wu","year":"2005","journal-title":"NeuroRx"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2740","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/cne.21159","article-title":"Distribution of neuropeptide S receptor mRNA and neurochemical characteristics of neuropeptide S-expressing neurons in the rat brain","volume":"500","author":"Xu","year":"2007","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2735","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1523\/JNEUROSCI.5716-08.2009","article-title":"mGluR5 has a critical role in inhibitory learning","volume":"29","author":"Xu","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2745","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.neulet.2010.11.038","article-title":"Facilitating actions of an AMPA receptor potentiator upon extinction of contextually conditioned fear response in stressed mice","volume":"488","author":"Yamada","year":"2011","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2750","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1038\/npp.2009.86","article-title":"Pharmacological discrimination of extinction and reconsolidation of contextual fear memory by a potentiator of AMPA receptors","volume":"34","author":"Yamada","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2755","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1038\/sj.npp.1301605","article-title":"Effects of single prolonged stress and D-cycloserine on contextual fear extinction and hippocampal NMDA receptor expression in a rat model of PTSD","volume":"33","author":"Yamamoto","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2770","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/sj.npp.1300899","article-title":"Systemic and intra-amygdala administration of glucocorticoid agonist and antagonist modulate extinction of conditioned fear","volume":"31","author":"Yang","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2775","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/sj.npp.1301215","article-title":"Glutamate NMDA receptors within the amygdala participate in the modulatory effect of glucocorticoids on extinction of conditioned fear in rats","volume":"32","author":"Yang","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2765","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.neuroscience.2005.04.003","article-title":"Facilitation of conditioned fear extinction by d-cycloserine is mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase cascades and requires de novo protein synthesis in basolateral nucleus of amygdala","volume":"134","author":"Yang","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2760","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.bbr.2012.02.023","article-title":"Venlafaxine facilitates between-session extinction and prevents reinstatement of auditory-cue conditioned fear","volume":"230","author":"Yang","year":"2012","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2780","doi-asserted-by":"crossref","first-page":"5979","DOI":"10.1128\/MCB.21.17.5979-5991.2001","article-title":"Regulation of transcription factor YY1 by acetylation and deacetylation","volume":"21","author":"Yao","year":"2001","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2785","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1111\/j.1460-9568.2004.03642.x","article-title":"GABA receptors containing the alpha5 subunit mediate the trace effect in aversive and appetitive conditioning and extinction of conditioned fear","volume":"20","author":"Yee","year":"2004","journal-title":"Eur J Neurosci"},{"issue":"Suppl 1","key":"10.1016\/j.pharmthera.2014.12.004_bb5000","first-page":"29","article-title":"Risk and resilience in posttraumatic stress disorder","volume":"65","author":"Yehuda","year":"2004","journal-title":"J Clin Psychiatry."},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2790","doi-asserted-by":"crossref","DOI":"10.3402\/ejpt.v1i0.5643","article-title":"Glucocorticoid augmentation of prolonged exposure therapy: Rationale and case report","volume":"1","author":"Yehuda","year":"2010","journal-title":"Eur J Psychotraumatol"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2795","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.nlm.2012.04.009","article-title":"Increased levels of conditioned fear and avoidance behavior coincide with changes in phosphorylation of the protein kinase B (AKT) within the amygdala in a mouse model of extremes in trait anxiety","volume":"98","author":"Yen","year":"2012","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2800","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neulet.2004.12.047","article-title":"Amygdalic levels of dopamine and serotonin rise upon exposure to conditioned fear stress without elevation of glutamate","volume":"379","author":"Yokoyama","year":"2005","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2805","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1523\/JNEUROSCI.5539-08.2009","article-title":"Variant BDNF Val66Met polymorphism affects extinction of conditioned aversive memory","volume":"29","author":"Yu","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2810","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.brainres.2009.07.074","article-title":"Extracellular serotonin level in the basolateral nucleus of the amygdala and dorsal periaqueductal gray under unconditioned and conditioned fear states: An in vivo microdialysis study","volume":"1294","author":"Zanoveli","year":"2009","journal-title":"Brain Res"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2815","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.biopsych.2012.08.006","article-title":"Cholinergic blockade frees fear extinction from its contextual dependency","volume":"73","author":"Zelikowsky","year":"2013","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2820","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.neuropharm.2012.06.007","article-title":"Stimulation of serotonin 2A receptors facilitates consolidation and extinction of fear memory in C57BL\/6J mice","volume":"64","author":"Zhang","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2825","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1111\/j.1460-9568.2010.07223.x","article-title":"NMDA receptor antagonism in the basolateral but not central amygdala blocks the extinction of Pavlovian fear conditioning in rats","volume":"31","author":"Zimmerman","year":"2010","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2830","first-page":"56","article-title":"Brain oxytocin in social fear conditioning and its extinction: Involvement of the lateral septum","volume":"98","author":"Zoicas","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2014.12.004_bb2835","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1523\/JNEUROSCI.3842-06.2007","article-title":"Facilitation of extinction learning for contextual fear memory by PEPA: A potentiator of AMPA receptors","volume":"27","author":"Zushida","year":"2007","journal-title":"J Neurosci"}],"container-title":["Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725814002332?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725814002332?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T11:29:24Z","timestamp":1747308564000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725814002332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":567,"alternative-id":["S0163725814002332"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2014.12.004","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders","name":"articletitle","label":"Article Title"},{"value":"Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmthera.2014.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}