{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T07:43:14Z","timestamp":1781854994666,"version":"3.54.5"},"reference-count":226,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002879","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["43923"],"award-info":[{"award-number":["43923"]}],"id":[{"id":"10.13039\/501100002879","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002879","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["82049"],"award-info":[{"award-number":["82049"]}],"id":[{"id":"10.13039\/501100002879","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"crossref","award":["2U19AI070535"],"award-info":[{"award-number":["2U19AI070535"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.pharmthera.2014.12.005","type":"journal-article","created":{"date-parts":[[2014,12,27]],"date-time":"2014-12-27T16:46:38Z","timestamp":1419698798000},"page":"185-198","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Virus-induced modulation of lower airway diseases: Pathogenesis and pharmacologic approaches to treatment"],"prefix":"10.1016","volume":"148","author":[{"given":"Richard","family":"Leigh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Proud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharmthera.2014.12.005_bb0005","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1056\/NEJMoa023161","article-title":"Outpaitent oral prednisone after emergency treatment of chronic obstructive pulmonary disease","volume":"348","author":"Aaron","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0010","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/35099560","article-title":"Recognition of double-stranded RNA and activation of NF-kB by Toll-like receptor 3","volume":"413","author":"Alexopoulou","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0015","doi-asserted-by":"crossref","first-page":"a48","DOI":"10.2741\/986","article-title":"Replication of respiratory syncytial virus is inhibited in target cells generating nitric oxide in situ","volume":"8","author":"Ali-Ahmad","year":"2003","journal-title":"Front Biosci"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0020","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1099\/vir.0.80164-0","article-title":"Rhinovirus 3C protease precursors 3CD and 3CD\u2032 localize to the nuclei of infected cells","volume":"85","author":"Amineva","year":"2004","journal-title":"J Gen Virol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0025","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1177\/000348949009900607","article-title":"Rhinovirus in otitis media with effusion","volume":"99","author":"Arola","year":"1990","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0030","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1128\/JCM.35.11.2864-2868.1997","article-title":"Frequency and natural history of rhinovirus infections in adults during autumn","volume":"35","author":"Arruda","year":"1997","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0035","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1165\/rcmb.2002-0166TR","article-title":"Matrix metalloproteinase-9 in lung remodeling","volume":"28","author":"Atkinson","year":"2003","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0040","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.jaci.2007.01.015","article-title":"New molecular targets for neutrophilic disease","volume":"119","author":"Barnes","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0045","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1183\/09031936.00138707","article-title":"Global strategy for asthma management and prevention: GINA executive summary","volume":"31","author":"Bateman","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0050","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.jaci.2013.01.034","article-title":"Do oral corticosteroids reduce the severity of acute lower respiratory tract illness in preschool children with recurrent wheezing?","volume":"131","author":"Beigelman","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0055","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1128\/JVI.02309-06","article-title":"Rhinovirus activates interleukin-8 expression via a Src\/p110\u03b2 phosphatylinositol 3-kinase pathway in human airway epithelial cells","volume":"81","author":"Bentley","year":"2007","journal-title":"J Virol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0060","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1164\/rccm.200706-910OC","article-title":"Study of montelukast for the treatment of respiratory symptoms of post-respiratory synytial virus bronchiolitis in children","volume":"178","author":"Bisgaard","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0065","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1056\/NEJMoa054692","article-title":"Intermittent inhaled corticosteroids in infants with episodic wheezing","volume":"354","author":"Bisgaard","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0070","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1164\/rccm.200407-894OC","article-title":"Montelukast reduces asthma exacerbations in 2- to 5-year-old children with intermittent asthma","volume":"171","author":"Bisgaard","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0075","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1465-9921-14-98","article-title":"Budesonide and formoterol effects on rhinovirus replication and epithelial cell cytokine responses","volume":"14","author":"Bochkov","year":"2013","journal-title":"Respir Res"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0080","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/mi.2009.109","article-title":"Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma","volume":"3","author":"Bochkov","year":"2010","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1135","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1164\/ajrccm.162.4.9910051","article-title":"Airway hyperresponsiveness, inflammation and subepithelial collagen deposition in recently diagnosed versus long-standing mild asthma. Influence of corticosteroids","volume":"162","author":"Boulet","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0090","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.jaci.2008.01.031","article-title":"Immunologic and inflammatory mechanisms that drive asthma progression to remodeling","volume":"121","author":"Broide","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0095","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1136\/bmj.320.7245.1297","article-title":"Randomized, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: The ISOLDE trial","volume":"320","author":"Burge","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0100","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1067\/mai.2001.117880","article-title":"Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma","volume":"108","author":"Busse","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0105","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1056\/NEJMoa1009705","article-title":"Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children","volume":"364","author":"Busse","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0110","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1056\/NEJMoa063070","article-title":"Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease","volume":"356","author":"Calverley","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0115","first-page":"CD002873","article-title":"Short acting beta agonists for recurrent wheeze in children under 2years of age","volume":"3","author":"Chavasse","year":"2002","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0120","doi-asserted-by":"crossref","first-page":"15125","DOI":"10.1073\/pnas.011593298","article-title":"Viperin (cig5), and IFN-inducible antiviral protein directly induced by human cytomegalovirus","volume":"98","author":"Chin","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1140","doi-asserted-by":"crossref","first-page":"e620","DOI":"10.1542\/peds.2014-1666","article-title":"Updated guidance for palivizumab prophylaxis among infants and young children at increased risk of hospitalization for respiratory syncytial virus infection","volume":"134","author":"Committee on infectious diseases and bronchiolitis guideline committee","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0130","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/nm1462","article-title":"Role of deficient type-III interferon-\u03bb production in asthma exacerbations","volume":"12","author":"Contoli","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0135","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.4049\/jimmunol.154.9.4719","article-title":"Glucocorticoid treatment inhibits apoptosis in human neutrophils","volume":"154","author":"Cox","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0140","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/S0140-6736(98)11326-0","article-title":"Oral corticosteroids in patients admitted to hospital with exacerbations of chronic obstructive pulmonary disease: A prospective randomized control trial","volume":"354","author":"Davies","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0145","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1164\/rccm.201312-2235OC","article-title":"The effect of inhaled IFN-\u03b2 on worsening of asthma symptoms caused by viral infections. A randomized trial","volume":"190","author":"Djukanovic","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0150","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1164\/ajrccm\/145.3.669","article-title":"Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma","volume":"145","author":"Djukanovic","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0155","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1164\/rccm.200312-1651OC","article-title":"Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma","volume":"170","author":"Djukanovic","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0160","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1165\/rcmb.2009-0266OC","article-title":"Cigarette smoke decreases the innate responses of epithelial cells to rhinovirus infection","volume":"44","author":"Eddleston","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0165","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1378\/chest.122.3.935","article-title":"Early ribavirin treatment of bronchiolitis. Effect on long-term respiratory morbidity","volume":"122","author":"Edell","year":"2002","journal-title":"Chest"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0170","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.virol.2004.01.033","article-title":"Does Toll-like receptor 3 play a biological role in virus infections?","volume":"322","author":"Edelmann","year":"2004","journal-title":"Virology"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0175","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.jaci.2009.08.044","article-title":"Tissue remodeling induced by hypersecreted epidermal growth factor and amphiregulin in the airway after an acute asthma attack","volume":"124","author":"Enomoto","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0180","first-page":"CD001279","article-title":"Anticholinergic drugs for wheeze in children under the age of two years","volume":"3","author":"Everard","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0185","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1164\/rccm.200301-019OC","article-title":"Inhaled corticosteroids in chronic obstructive pulmonary disease and risk of death and hospitalization","volume":"168","author":"Fan","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0190","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1093\/infdis\/162.5.1173","article-title":"A randomized controlled trial of glucocorticoid prophylaxis against experimental rhinovirus infection","volume":"162","author":"Farr","year":"1990","journal-title":"J Infect Dis"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0195","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1001\/archinte.163.4.487","article-title":"The burden of non-influenza related viral respiratory tract infections in the United States","volume":"163","author":"Fendrick","year":"2003","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0200","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/S0140-6736(69)90639-4","article-title":"Protective effect of 1-adamantanamine hydrochloride in influenza A2 infections in the family environment: A controlled double-blind study","volume":"294","author":"Galbraith","year":"1969","journal-title":"Lancet"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0205","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1067\/mpd.2001.117006","article-title":"Breast-feeding and the risk of bronchial asthma in childhood: A systematic review with meta-analysis of prospective studies","volume":"139","author":"Gdalevich","year":"2001","journal-title":"J Pediatr"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0210","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S1081-1206(10)63529-6","article-title":"Elevations of local leukotriene C4 levels during viral upper respiratory tract infections","volume":"91","author":"Gentile","year":"2003","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0215","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1172\/JCI8272","article-title":"Early life origins of asthma","volume":"104","author":"Gern","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0220","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.jaci.2005.01.057","article-title":"Effects of viral respiratory infections on lung development and childhood asthma","volume":"115","author":"Gern","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0225","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1164\/rccm.200605-722OC","article-title":"Regular smoking and asthma incidence in adolescents","volume":"174","author":"Gilliland","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0230","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1164\/ajrccm.162.1.9911019","article-title":"Respiratory viral infections in adults with and without chronic obstructive pulmonary disease","volume":"162","author":"Greenberg","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0235","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.4049\/jimmunol.171.4.2099","article-title":"Intracellular domain of brain endothelial intercellular adhesion molecule-1 is essential for T lymphocyte-mediated signaling and migration","volume":"171","author":"Greenwood","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0240","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1164\/rccm.200905-0725OC","article-title":"Overexpression of Smad2 drives house dust mite-mediated airway remodeling and airway hyperresponsiveness via activin and IL-25","volume":"182","author":"Gregory","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0245","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/0092-8674(89)90688-0","article-title":"The major human rhinovirus receptor is ICAM-1","volume":"56","author":"Greve","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1145","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1164\/ajrccm.164.10.2102118","article-title":"Rhinovirus-induced airway inflammation in asthma: Effect of treatment with inhaled corticosteroids before and during experimental infection","volume":"164","author":"Grunberg","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0255","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1056\/NEJMoa051378","article-title":"Long-term inhaled corticosteroids in preschool children at high risk for asthma","volume":"354","author":"Guilbert","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0260","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0091-6749(96)80077-7","article-title":"Oral prednisone therapy in experimental rhinovirus infections","volume":"97","author":"Gustafson","year":"1996","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0265","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1056\/NEJM199401063300105","article-title":"Computed tomographic study of the common cold","volume":"330","author":"Gwaltney","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0270","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1056\/NEJMoa0808991","article-title":"Mepolizumab and exacerbations of refractory eosinophilic asthma","volume":"360","author":"Haldar","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0275","doi-asserted-by":"crossref","first-page":"5561","DOI":"10.1128\/JVI.01857-06","article-title":"A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L","volume":"81","author":"Han","year":"2007","journal-title":"J Virol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1150","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1056\/NEJM198601093140202","article-title":"Prevention of natural colds by contact prophylaxis with intranasal alpha 2-interferon","volume":"314","author":"Hayden","year":"1986","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0280","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1056\/NEJM198912213212502","article-title":"Emergence and apparent transmission of rimantadine-resistant influenza A virus in families","volume":"321","author":"Hayden","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0285","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1056\/NEJM200011023431801","article-title":"Inhaled zanamivir for the prevention of influenza in families","volume":"343","author":"Hayden","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0290","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/infdis\/148.3.543","article-title":"Intranasal interferon \u03b12 for prevention of rhinovirus infection and illness","volume":"148","author":"Hayden","year":"1983","journal-title":"J Infect Dis"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0295","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1093\/infdis\/150.2.174","article-title":"Intranasal interferon-\u03b12 treatment of experimental rhinoviral colds","volume":"150","author":"Hayden","year":"1984","journal-title":"J Infect Dis"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0300","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1086\/375069","article-title":"Efficacy and safety of oral pleconaril for treatment of colds due to picornaviruses in adults: Results of 2 double-blind, randomized, placebo-controlled trials","volume":"36","author":"Hayden","year":"2003","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0310","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1001\/jama.282.13.1240","article-title":"Use of the oral neuraminidase inhibitor oseltamivir in experimental human influenza. Randomized controlled trials for prevention and treatment","volume":"282","author":"Hayden","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0315","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1128\/AAC.47.12.3907-3916.2003","article-title":"Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers","volume":"47","author":"Hayden","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0320","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1183\/09031936.00026910","article-title":"Rhinovirus induces MUC5AC in a human infection model and in vitro via NF-\u03baB and EGFR pathways","volume":"36","author":"Hewson","year":"2010","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0325","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jaci.2004.04.006","article-title":"Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing","volume":"114","author":"Heymann","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0330","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1089\/jir.1986.6.153","article-title":"Interferon-beta ser as prophylaxis against experimental rhinovirus infection in volunteers","volume":"6","author":"Higgins","year":"1986","journal-title":"J Interferon Res"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0335","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1164\/rccm.200402-227OC","article-title":"Efficacy of fluticasone propionate on lung function and symptoms in wheezy infants","volume":"171","author":"Hofhuis","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0340","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.jaci.2007.10.025","article-title":"Epithelium dysfunction in asthma","volume":"120","author":"Holgate","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0345","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2332\/allergolint.O-06-473","article-title":"Clinical evaluation of leukotriene receptor antagonists in preventing common cold-like symptoms in bronchial asthma patients","volume":"56","author":"Horiguchi","year":"2007","journal-title":"Allergol Int"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0350","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.biochi.2007.02.003","article-title":"The human 2\u2032-5\u2032 oligoadenylate synthetase family: Unique interferon-inducible enzymes catalyzing 2\u2032-5\u2032 instead of 3\u2032-5\u2032 phosphodiester bond formation","volume":"89","author":"Hovanessian","year":"2007","journal-title":"Biochimie"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0355","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1465-9921-14-88","article-title":"Cigarette smoke enhances human rhinovirus-induced CXCL8 production via HuR-mediated mRNA stabilization in human airway epithelial cells","volume":"14","author":"Hudy","year":"2013","journal-title":"Respir Res"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0360","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1165\/rcmb.2013-0129OC","article-title":"Transcriptional and epigenetic modulation of human rhinovirus-induced CXCL10 production by cigarette smoke","volume":"50","author":"Hudy","year":"2014","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0365","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1183\/09031936.00128809","article-title":"Cigarette smoke modulates rhinovirus-induced airway epithelial chemokine production","volume":"35","author":"Hudy","year":"2010","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0370","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.jaip.2014.03.010","article-title":"Omalizumab in asthma: An update on recent developments","volume":"2","author":"Humbert","year":"2014","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0375","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.resp.2005.11.006","article-title":"Mechanisms of mucin production by rhinovirus infection in cultured human airway epithelial cells","volume":"154","author":"Inoue","year":"2006","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0380","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1164\/rccm.201104-0660OC","article-title":"Evidence for a causal relationship between allergic sensitization and rhinovirus wheezing in early life","volume":"185","author":"Jackson","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0385","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1164\/rccm.200802-309OC","article-title":"Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children","volume":"178","author":"Jackson","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0390","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1183\/09031936.00146905","article-title":"Clinical relevance of airway remodelling in airway diseases","volume":"30","author":"James","year":"2007","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0395","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1067\/mai.2000.106376","article-title":"The effect of an experimental rhinovirus 16 infection on bronchial lavage neutrophils","volume":"105","author":"Jarjour","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0400","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1183\/09031936.00161907","article-title":"Serial viral infections in infants with recurrent respiratory illnesses","volume":"32","author":"Jartti","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1155","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.3201\/eid1006.030629","article-title":"Respiratory picornaviruses and respiratory syncytial virus as causative agents of acute expiratory wheezing in children","volume":"10","author":"Jartti","year":"2004","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0410","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1513\/pats.200402-009MS","article-title":"Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease","volume":"1","author":"Jeffery","year":"2004","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0415","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1164\/ajrccm\/145.4_Pt_1.890","article-title":"Effect of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma. A quantitative light and elctron microscopic study","volume":"145","author":"Jeffery","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0420","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1164\/ajrccm\/140.6.1745","article-title":"Bronchial biopsies in asthma: An ultrastructural, quantitative study and correlation with hyperreactivity","volume":"140","author":"Jeffery","year":"1989","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0425","doi-asserted-by":"crossref","first-page":"e702","DOI":"10.1542\/peds.2006-3317","article-title":"Attenuation of the September epidemic of asthma exacerbations in children: A randomized, controlled trial of montelukast added to usual therapy","volume":"120","author":"Johnston","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0430","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1136\/bmj.310.6989.1225","article-title":"Community study of role of viral infections in exacerbations of asthma in 9\u201311 year old children","volume":"310","author":"Johnston","year":"1995","journal-title":"Br Med J"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0435","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1164\/ajrccm.163.2.9912068","article-title":"Induction and regulation of nitric oxide synthase in airway epithelial cells by respiratory syncytial virus","volume":"163","author":"Kao","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0440","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.immuni.2005.04.010","article-title":"Cell type-specific involvement of RIG-I in antiviral response","volume":"23","author":"Kato","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0445","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1084\/jem.20080091","article-title":"Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5","volume":"205","author":"Kato","year":"2008","journal-title":"J Exp Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0450","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature04734","article-title":"Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses","volume":"414","author":"Kato","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0455","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1164\/ajrccm.155.2.9032192","article-title":"Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD","volume":"155","author":"Keatings","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0460","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jaci.2009.09.011","article-title":"Effects of budesonide and formoterol on allergen-induced airway responses, inflammation and airway remodeling in asthma","volume":"125","author":"Kelly","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0465","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1398-9995.2008.01826.x","article-title":"Respiratory virus induction of alpha-, beta, and lambda-interferons in bronchial epithelial cells and peripheral blood mononuclear cells","volume":"64","author":"Khaitov","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0470","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jaci.2006.08.041","article-title":"Prevalence of viral respiratory tract infections in children with asthma","volume":"119","author":"Khetsuriani","year":"2007","journal-title":"J Allergy Clin Immunol"},{"issue":"Suppl. 1","key":"10.1016\/j.pharmthera.2014.12.005_bb0475","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1186\/rr183","article-title":"Prevention and treatment of respiratory syncytial virus bronchiolitis and postbronchiolitic wheezing","volume":"3","author":"Kimpen","year":"2002","journal-title":"Respir Res"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0480","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1086\/520816","article-title":"Pan-viral screening of respiratory tract infections in adults with and without asthma reveals unexpected human coronavirus and human rhinovirus diversity","volume":"196","author":"Kistler","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0485","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.anai.2010.11.021","article-title":"Effects of montelukast in subjects with asthma after experimental inoculation with rhinovirus-16","volume":"106","author":"Kloepfer","year":"2011","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0490","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.jaci.2009.04.041","article-title":"Nitric oxide inhibits IFN regulatory factor 1 and nuclear factor-\u03baB pathways in rhinovirus-infected epithelial cells","volume":"124","author":"Koetzler","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0495","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jaci.2008.09.041","article-title":"Nitric oxide inhibits human rhinovirus-induced transcriptional activation of CXCL10 in airway epithelial cells","volume":"123","author":"Koetzler","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0500","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1097\/01.inf.0000143642.72480.53","article-title":"Rhinovirus-associated wheezing in infancy. Comparison with respiratory syncytial virus bronchiolitis","volume":"23","author":"Korppi","year":"2004","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0505","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1067\/mai.2003.33","article-title":"Rhinovirus-induced wheezing in infancy-the first sign of childhood asthma?","volume":"111","author":"Kotaniemi-Syrj\u00e4nen","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0510","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.virol.2008.01.022","article-title":"Attenuation of the type I interferon response in cells infected with human rhinovirus","volume":"374","author":"Kotla","year":"2008","journal-title":"Virology"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0515","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1378\/chest.06-3008","article-title":"Increased risk of childhood asthma from antibiotic use in early life","volume":"131","author":"Kozyrskyj","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0520","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1164\/arrd.1985.131.4.599","article-title":"Damage to the airway epithelium and bronchial reactivity in patients with asthma","volume":"131","author":"Laitinen","year":"1985","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0525","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1136\/thx.2003.014894","article-title":"Epithelial inducible nitric oxide synthase activity is the major determinant of nitric oxide concentration in exhaled breath","volume":"59","author":"Lane","year":"2004","journal-title":"Thorax"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0530","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.jaci.2009.09.021","article-title":"Omalizumab for the treatment of exacerbations in children with inadequately controlled allergic (IgE-mediated) asthma","volume":"124","author":"Lanier","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0535","doi-asserted-by":"crossref","first-page":"870","DOI":"10.4049\/jimmunol.180.2.870","article-title":"Syk associates with clathrin and mediates phosphatidylinositol 3-kinase activation during human rhinovirus internalization","volume":"180","author":"Lau","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0540","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1164\/rccm.200511-1746OC","article-title":"Smoking affacts response to inhaled corticosteroids or leukotriene receptor antagonists in asthma","volume":"175","author":"Lazarus","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0545","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.jaci.2008.01.067","article-title":"Human rhinovirus infection enhances airway epithelial cell production of growth factors involved in airway remodeling","volume":"121","author":"Leigh","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0550","doi-asserted-by":"crossref","first-page":"375","DOI":"10.2217\/fvl.11.9","article-title":"Modulation of epithelial biology by rhinovirus infection: Role in inflammatory airway diseases","volume":"6","author":"Leigh","year":"2011","journal-title":"Future Virol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0555","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jaci.2005.06.024","article-title":"Rhinovirus illnesses during infancy predict subsequent childhood wheezing","volume":"116","author":"Lemanske","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0560","doi-asserted-by":"crossref","first-page":"e59872","DOI":"10.1371\/journal.pone.0059872","article-title":"Efficacy of anti-interleukin-5 therapy with mepolizumab in patients with asthma: A meta-analysis of randomized placebo-controlled trials","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0565","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.jaci.2009.03.010","article-title":"In vitro susceptibility to rhinovirus infection is greater for bronchial than for nasal airway epithelial cells in human subjects","volume":"123","author":"Lopez-Souza","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0570","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1155\/2012\/635624","article-title":"Canadian Thoracic Society 2012 guideline update: Diagnosis and management of asthma in preschoolers, children and adults","volume":"19","author":"Lougheed","year":"2012","journal-title":"Can Respir J"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0575","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.ccm.2012.05.004","article-title":"Corticosteroids. Still at the frontline of asthma treatment?","volume":"33","author":"Louis","year":"2012","journal-title":"Clin Chest Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0580","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.4049\/jimmunol.1303322","article-title":"DHX15 senses double-stranded RNA in myeloid dendritic cells","volume":"193","author":"Lu","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0585","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1128\/JCM.36.2.539-542.1998","article-title":"Viruses and bacteria in the etiology of the common cold","volume":"36","author":"Makela","year":"1998","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0590","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1164\/rccm.201006-0833OC","article-title":"Experimental rhinovirus infection as a human model of chronic obstructive pulmonary disease exacerbation","volume":"183","author":"Mallia","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0595","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1056\/NEJM198810273191702","article-title":"Diminished lung function as a predisposing factor for wheezing respiratory illness in infants","volume":"319","author":"Martinez","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0600","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.rmed.2008.06.006","article-title":"Respiratory viral infection in exacerbations of COPD","volume":"102","author":"McManus","year":"2008","journal-title":"Respir Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0605","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1152\/japplphysiol.00159.2003","article-title":"Airway wall remodeling: Friend or foe?","volume":"95","author":"McParland","year":"2003","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0610","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1164\/rccm.200407-970OC","article-title":"Quantitative and qualitative analysis of rhinovirus infection in bronchial tissues","volume":"171","author":"Mosser","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0615","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.smim.2009.05.001","article-title":"RIG-I-like receptors: Sensing and responding to RNA virus infection","volume":"21","author":"Nakhaei","year":"2009","journal-title":"Semin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0620","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1136\/bmj.307.6910.982","article-title":"Respiratory viruses and exacerbations of asthma in adults","volume":"307","author":"Nicholson","year":"1993","journal-title":"Br Med J"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0625","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1056\/NEJM199906243402502","article-title":"Effect of systemic glucocorticoids on exacerbations of chronic obstructive pulmonary disease. Department of Veterans Affairs Cooperative Study Group","volume":"340","author":"Niewoehner","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0630","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.3109\/07853890008995945","article-title":"Daycare attendance, asthma and atopy","volume":"32","author":"Nystad","year":"2000","journal-title":"Ann Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0650","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1600-065X.2011.01029.x","article-title":"The genetics of asthma and allergic disease: A 21st century perspective","volume":"242","author":"Ober","year":"2011","journal-title":"Immunol Rev"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0635","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1164\/ajrccm.164.8.2104102","article-title":"Low dose inhaled budesonide and formoterol in mild persistent asthma: The OPTIMA randomized trial","volume":"164","author":"O'Byrne","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0640","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1164\/rccm.200407-884OC","article-title":"Budesonide\/formoterol combination therapy as both maintenance and reliever medication in asthma","volume":"171","author":"O'Byrne","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0655","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/S0140-6736(03)14685-5","article-title":"Efficacy of a short course of parent-initiated oral prednisolone for viral wheeze in children aged 1\u20135years: Randomized controlled trial","volume":"362","author":"Oommen","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0645","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.jaci.2012.08.044","article-title":"Increased airway smoth muscle in preschool wheezers who have asthma at school age","volume":"131","author":"O'Reilly","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0660","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1056\/NEJMoa1403290","article-title":"Mepolizumab treatment in patients with severe eosinophilic asthma","volume":"371","author":"Ortega","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0665","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.1165557","article-title":"Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution","volume":"324","author":"Palmenberg","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0670","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMoa0804897","article-title":"Oral prednisolone for preschool children with acute virus-induced wheezing","volume":"360","author":"Panicker","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0675","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1086\/315513","article-title":"Rhinoviruses infect the lower airways","volume":"181","author":"Papadopoulos","year":"2000","journal-title":"J Infect Dis"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0680","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1139\/Y07-051","article-title":"Structural basis for exaggerated airway narrowing","volume":"85","author":"Par\u00e9","year":"2007","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0685","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1067\/mpd.2003.196","article-title":"Randomized, double-blind, placebo-controlled trial of oral albuterol in infants with mild-to-moderate acute bronchiolitis","volume":"142","author":"Patel","year":"2003","journal-title":"J Pediatr"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0690","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1128\/AAC.49.6.2267-2275.2005","article-title":"In vitro antiviral activity and single-dose pharmacokinetics in humans of a novel, orally bioavailable inhibitor of human rhinovirus 3C protease","volume":"49","author":"Patick","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0695","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1164\/ajrccm.163.5.2101039","article-title":"Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI\/WHO global initiative for chronic obstructive lung disease (GOLD) workshop summary","volume":"163","author":"Pauwels","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0700","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1056\/NEJM199711133372001","article-title":"Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) international study group","volume":"337","author":"Pauwels","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0705","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0140-6736(12)60988-X","article-title":"Mepolizumab for severe eosinophilic asthma (DREAM): A multicentre, double-blind, placebo-controlled trial","volume":"380","author":"Pavord","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0710","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1128\/JVI.63.5.2002-2007.1989","article-title":"Conformational change in the floor of the human rhinovirus canyon blocks absorption to HeLa cell receptors","volume":"63","author":"Pevear","year":"1989","journal-title":"J Virol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0715","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1399-3038.2005.00239.x","article-title":"Markers of eosinophilic inflammation and tissue re-modelling in children before clinically diagnosed bronchial asthma","volume":"16","author":"Pohunek","year":"2005","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0720","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1111\/j.1651-2227.2009.01463.x","article-title":"Montelukast does not prevent reactive airway disease in young children hospitalized for RSV bronchiolitis","volume":"98","author":"Proesmans","year":"2009","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0725","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/00130832-200502000-00008","article-title":"Nitric oxide and the common cold","volume":"5","author":"Proud","year":"2005","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0730","doi-asserted-by":"crossref","first-page":"e40762","DOI":"10.1371\/journal.pone.0040762","article-title":"Cigarette smoke modulates expression of human rhinovirus-induced airway epithelial host defense genes","volume":"7","author":"Proud","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0735","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1164\/rccm.200805-670OC","article-title":"Gene expression profiles during in vivo human rhinovirus infection: Insights into the host response","volume":"178","author":"Proud","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0740","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jaci.2005.11.005","article-title":"Vascular endothelial growth factor-mediated induction of angiogenesis by human rhinovirus","volume":"117","author":"Psarras","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0745","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1164\/rccm.200208-794OC","article-title":"Biopsy neutrophilia, neutrophil chemokine and receptor gene expression in severe exacerbations of chronic obstructive pulmonary disease","volume":"168","author":"Qiu","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0750","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.jaci.2006.12.640","article-title":"The neutrophil in chronic obstructive pulmonary disease","volume":"119","author":"Quint","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0755","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S0140-6736(06)69284-2","article-title":"Effect of budesonide in combination with formoterol for reliever therapy in asthma exacerbations: A randomized controlled, double-blind study","volume":"368","author":"Rabe","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0760","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1542\/peds.112.2.382","article-title":"Treating exacerbations of asthma in children: The role of systemic corticosteroids","volume":"112","author":"Rachelefsky","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0765","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1164\/ajrccm.159.3.9801052","article-title":"Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care. IgE and eosinophil analyses","volume":"159","author":"Rakes","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0770","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1542\/peds.106.6.1406","article-title":"Predictors of asthma three years after hospital admission for wheezing in infancy","volume":"106","author":"Reijonen","year":"2000","journal-title":"Pediatrics"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1160","doi-asserted-by":"crossref","first-page":"8880","DOI":"10.1128\/JVI.73.10.8880-8883.1999","article-title":"Inhibition of influenza virus replication by nitric oxide","volume":"73","author":"Rimmelzwaan","year":"1999","journal-title":"J Virol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0780","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1164\/rccm.200510-1546OC","article-title":"Short-course montelukast for intermittent asthma in children: A randomized controlled trial","volume":"175","author":"Robertson","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0785","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.rmed.2003.11.016","article-title":"Corticosteroid therapy for acute asthma","volume":"98","author":"Rowe","year":"2004","journal-title":"Respir Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0790","first-page":"CD000195","article-title":"Corticosteroids for preventing relapse following acute exacerbations of asthma","volume":"3","author":"Rowe","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0795","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1164\/rccm.200410-1404OC","article-title":"Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction","volume":"171","author":"Saglani","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0800","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1164\/rccm.200702-212OC","article-title":"Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers","volume":"176","author":"Saglani","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0805","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1164\/rccm.200801-136OC","article-title":"Rhinovirus disrupts the barrier function of polarized airway epithelial cells","volume":"178","author":"Sajjan","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0810","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.antiviral.2013.03.014","article-title":"Influenza virus resistance to neuraminidase inhibitors","volume":"98","author":"Samson","year":"2013","journal-title":"Antiviral Res"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0815","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.jaci.2004.01.755","article-title":"Role of nasal nitric oxide in the resolution of experimental rhinovirus infection","volume":"113","author":"Sanders","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0820","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1128\/JVI.72.2.934-942.1998","article-title":"Nitric oxide inhibits rhinovirus-induced cytokine production and viral replication in a human respiratory epithelial cell line","volume":"72","author":"Sanders","year":"1998","journal-title":"J Virol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0825","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1067\/mai.2001.112028","article-title":"Rhinovirus infection induces expression of type 2 nitric oxide synthase in human respiratory epithelial cells in vitro and in vivo","volume":"107","author":"Sanders","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0830","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/cc1466","article-title":"Do bronchodilators have an effect on bronchiolitis?","volume":"6","author":"Schindler","year":"2002","journal-title":"Crit Care"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0835","doi-asserted-by":"crossref","first-page":"42013","DOI":"10.1074\/jbc.M110.165936","article-title":"Transcription factor redundancy ensures induction of the antiviral state","volume":"285","author":"Schmid","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0840","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1164\/rccm.200911-1673OC","article-title":"Increased cytokine response of rhinovirus-infected airway epithelial cells in chronic obstructive pulmonary disease","volume":"182","author":"Schneider","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0845","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1185\/030079904X2051","article-title":"Efficacy and safety of budesonide\/formoterol single inhaler therapy versus a higher dose of budesonide in moderate to severe asthma","volume":"20","author":"Scicchitano","year":"2004","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0850","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1056\/NEJMoa022363","article-title":"A longitudinal, population-based, cohort study of childooh asthma followed to adulthood","volume":"349","author":"Sears","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0855","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1164\/ajrccm.164.9.2105011","article-title":"Respiratory viruses, symptoms and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease","volume":"164","author":"Seemungal","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0860","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.bbrc.2009.12.070","article-title":"Structural characterization reveals that viperin is a radical S-adenosyl-l-methionine (SAM) enzyme","volume":"391","author":"Shaveta","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1165","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.jaci.2007.05.028","article-title":"Vascular remodeling is a feature of asthma and nonasthmatic eosinophil bronchitis","volume":"120","author":"Siddiqui","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0870","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1164\/ajrccm.161.5.9906076","article-title":"Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7","volume":"161","author":"Sigurs","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0875","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1164\/rccm.200406-730OC","article-title":"Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13","volume":"171","author":"Sigurs","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0880","doi-asserted-by":"crossref","first-page":"12720","DOI":"10.1128\/JVI.01471-07","article-title":"Viral encounters with 2\u2032,5\u2032-oligoadenylate synthetase and RNase L during the interferon antiviral response","volume":"81","author":"Silverman","year":"2007","journal-title":"J Virol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0885","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1164\/rccm.200701-042OC","article-title":"Proangiogenic activity in bronchoalveolar lavage fluid from patients with asthma","volume":"176","author":"Simcock","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0890","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1164\/ajrccm.164.4.2009033","article-title":"Inhaled corticosteroids and the risk of mortality and readmission in elderly patients with chronic obstructive pulmonary disease","volume":"164","author":"Sin","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0895","doi-asserted-by":"crossref","first-page":"e1001178","DOI":"10.1371\/journal.ppat.1001178","article-title":"Co-ordinated role of TLR-3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium","volume":"6","author":"Slater","year":"2010","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0905","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1126\/science.3018924","article-title":"The site of attachment in human rhinovirus 14 for antiviral agents that inhibit uncoating","volume":"233","author":"Smith","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0900","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1164\/ajrccm.156.3.9611072","article-title":"A national estimate of the economic costs of asthma","volume":"156","author":"Smith","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0910","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1164\/arrd.1984.130.2.289","article-title":"Quantitative structural alterations in long-standing allergic asthma","volume":"130","author":"Sobonya","year":"1984","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0915","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1183\/09031936.01.00092101","article-title":"The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics","volume":"18","author":"Soler","year":"2001","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0920","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1183\/09031936.02.00301302","article-title":"Survival in COPD patients after regular use of fluticasone propionate and salmeterol in general practice","volume":"20","author":"Soriano","year":"2002","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0925","doi-asserted-by":"crossref","first-page":"L85","DOI":"10.1152\/ajplung.00397.2004","article-title":"Human airway epithelial cells produce IP-10 (CXCL10) in vitro and in vivo upon rhinovirus infection","volume":"289","author":"Spurrell","year":"2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0930","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/0092-8674(89)90689-2","article-title":"A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses","volume":"56","author":"Staunton","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0935","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0140-6736(98)10321-5","article-title":"Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13years","volume":"354","author":"Stein","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0940","doi-asserted-by":"crossref","first-page":"5179","DOI":"10.4049\/jimmunol.0902264","article-title":"IFN regulatory factor-1 bypassess IFN-mediated antiviral effects through viperin gene induction","volume":"184","author":"Stirnweiss","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0945","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1164\/ajrccm\/144.3_Pt_1.655","article-title":"Lung function in school-age children who had mild lower respiratory illness in early childhood","volume":"144","author":"Strope","year":"1991","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0950","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1172\/JCI118067","article-title":"Infection of a human respiratory epithelial cell line with rhinovirus. Induction of cytokine release and modulation of susceptibility to infection by cytokine exposure","volume":"96","author":"Subauste","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0955","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1136\/thoraxjnl-2012-202909","article-title":"Rhinovirus-induced interferon production is not deficient in well controlled asthma","volume":"69","author":"Sykes","year":"2013","journal-title":"Thorax"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0960","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1165\/rcmb.2009-0216OC","article-title":"Human rhinovirus infection of airway epithelial cells upregulates MMP-9 production via NF-\u03baB","volume":"43","author":"Tacon","year":"2010","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0965","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1600-065X.2008.00737.x","article-title":"Innate immunity to virus infection","volume":"227","author":"Takeuchi","year":"2009","journal-title":"Immunol Rev"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0970","doi-asserted-by":"crossref","first-page":"467","DOI":"10.2165\/00151829-200605060-00010","article-title":"Corticosteroid insensitivity in smokers with asthma: Clinical evidence, mechanisms and management","volume":"5","author":"Thomson","year":"2006","journal-title":"Treat Respir Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0975","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.coph.2006.11.010","article-title":"Viral-associated exacerbations of asthma and COPD","volume":"7","author":"Traves","year":"2007","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0980","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4161\/viru.2.1.13807","article-title":"Human rhinovirus recognition in non-immune cells is mediated by Toll-like receptors and MDA-5, which trigger a synergetic pro-inflammatory immune response","volume":"2","author":"Triantafilou","year":"2011","journal-title":"Virulence"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0985","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1164\/ajrccm.150.1.8025745","article-title":"Placebo-controlled immunopathologic study of four months of inhaled corticosteroids in asthma","volume":"150","author":"Trigg","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb0990","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/0091-6749(92)90172-X","article-title":"Physiologic abnormalities of the paranasal sinuses during experimental rhinovirus colds","volume":"90","author":"Turner","year":"1992","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1170","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1001\/jama.281.19.1797","article-title":"Efficacy of tremacamra, a soluble intercellular adhesion molecule 1, for experimental rhinovirus infection","volume":"281","author":"Turner","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1000","doi-asserted-by":"crossref","first-page":"988","DOI":"10.4049\/jimmunol.165.2.988","article-title":"Central role of double-stranded RNA-activated protein kinase in microbial induction of nitric oxide synthase","volume":"165","author":"Uetani","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1005","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jcf.2005.05.011","article-title":"Viral respiratory infections in cystic fibrosis","volume":"4","author":"van Ewijk","year":"2005","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1010","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1016\/S0140-6736(98)10019-3","article-title":"Long-term effect of inhaled budesonide in mild and moderate chronic obstructive pulmonary disease: A randomized control trial","volume":"353","author":"Vestbo","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1175","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1203\/00006450-198810000-00018","article-title":"The release of leukotrienes in the respiratory tract during infection with respiratory syncytial virus: Role in obstructive airway disease","volume":"25","author":"Volovitz","year":"1988","journal-title":"Pediatr Res"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1020","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nri2871","article-title":"Farm living: Effects on childhood asthma and allergy","volume":"10","author":"von Mutius","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1030","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.chom.2007.06.009","article-title":"The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts","volume":"2","author":"Wang","year":"2007","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1035","doi-asserted-by":"crossref","first-page":"6859","DOI":"10.4049\/jimmunol.177.10.6859","article-title":"Syk is downstream of intercellular adhesion molecule-1 and mediates human rhinovirus activation of p38 MAPK in airway epithelial cells","volume":"177","author":"Wang","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1025","doi-asserted-by":"crossref","first-page":"6989","DOI":"10.4049\/jimmunol.0901386","article-title":"Role of double-stranded RNA pattern recognition receptors in rhinovirus-induced airway epithelial cell responses","volume":"183","author":"Wang","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1040","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1136\/thorax.57.4.309","article-title":"Airway inflammation, basement membrane tickening and bronchial hyperresponsiveness in asthma","volume":"57","author":"Ward","year":"2002","journal-title":"Thorax"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1045","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1084\/jem.20041901","article-title":"Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus","volume":"201","author":"Wark","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1050","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1183\/09031936.02.00226302","article-title":"Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma","volume":"19","author":"Wark","year":"2002","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1055","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.jcf.2007.12.002","article-title":"The role of respiratory viruses in cystic fibrosis","volume":"7","author":"Wat","year":"2008","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1060","first-page":"1204","article-title":"Exacerbations of chronic obstructive pulmonary disease","volume":"48","author":"Wedzicha","year":"2003","journal-title":"Respir Care"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1065","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1056\/NEJM199203263261304","article-title":"An economic evaluation of asthma in the United States","volume":"326","author":"Weiss","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1070","doi-asserted-by":"crossref","first-page":"L505","DOI":"10.1152\/ajplung.00066.2007","article-title":"Interleukin-17A modulates human airway epithelial responses to human rhinovirus infection","volume":"293","author":"Wiehler","year":"2007","journal-title":"Am J Physiol Cell Mol Physiol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1075","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1056\/NEJMoa025472","article-title":"Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children","volume":"350","author":"Williams","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1080","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1136\/adc.72.4.317","article-title":"Effect of continuous treatment with topical corticosteroid on episodic viral wheeze in preschool children","volume":"72","author":"Wilson","year":"1995","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1085","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3109\/00016488409130994","article-title":"Light and scanning electron microscopy of nasal biopsy material from patients with naturally acquired common colds","volume":"97","author":"Winther","year":"1984","journal-title":"Acta Otolaryngol (Stockh)"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1090","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/jmv.20588","article-title":"Picornavirus infection in children diagnosed by RT-PCR during longitudinal surveillance with weekly sampling: Association with symptomatic illness and effect of season","volume":"78","author":"Winther","year":"2006","journal-title":"J Med Virol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1095","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1164\/rccm.200903-0392OC","article-title":"T-helper type 2-driven inflammation defines major subtypes of asthma","volume":"180","author":"Woodruff","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1100","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/ni1087","article-title":"The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses","volume":"5","author":"Yoneyama","year":"2004","journal-title":"Nat Immunol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1105","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1165\/rcmb.2009-0203OC","article-title":"Human rhinovirus-induced epithelial production of CXCL10 is dependent upon IFN Regulatory Factor-1","volume":"43","author":"Zaheer","year":"2010","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1110","doi-asserted-by":"crossref","first-page":"11246","DOI":"10.1128\/JVI.01282-07","article-title":"Identification and characterization of interferon-induced proteins that inhibit alphavirus replication","volume":"81","author":"Zhang","year":"2007","journal-title":"J Virol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1115","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.immuni.2011.03.027","article-title":"DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells","volume":"34","author":"Zhang","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1120","doi-asserted-by":"crossref","first-page":"L374","DOI":"10.1152\/ajplung.00039.2004","article-title":"Impaired nitric oxide synthase-2 signaling pathway in cystic fibrosis airway epithelium","volume":"287","author":"Zheng","year":"2004","journal-title":"Am J Physiol Cell Mol Physiol"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1125","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1006\/viro.1999.9738","article-title":"Interferon action in triply deficient mice reveals the existence of alternative antiviral pathways","volume":"258","author":"Zhou","year":"1999","journal-title":"Virology"},{"key":"10.1016\/j.pharmthera.2014.12.005_bb1130","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1165\/rcmb.2008-0223OC","article-title":"Rhinovirus-induced major airway mucin production involves a novel TLR3-EGFR-dependent pathway","volume":"40","author":"Zhu","year":"2009","journal-title":"Am J Respir Cell Mol Biol"}],"container-title":["Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725814002344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725814002344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T05:04:28Z","timestamp":1690779868000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725814002344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":226,"alternative-id":["S0163725814002344"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2014.12.005","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Virus-induced modulation of lower airway diseases: Pathogenesis and pharmacologic approaches to treatment","name":"articletitle","label":"Article Title"},{"value":"Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmthera.2014.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}