{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:58:22Z","timestamp":1791809902278,"version":"4.3.4"},"reference-count":239,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,3]],"date-time":"2015-01-03T00:00:00Z","timestamp":1420243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P22424"],"award-info":[{"award-number":["P22424"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P27520"],"award-info":[{"award-number":["P27520"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Verein zur Foerderung der Forschung auf dem Gebiet der Neonatologie und Paediatrischen Intensivmedizin"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.pharmthera.2015.01.001","type":"journal-article","created":{"date-parts":[[2015,1,4]],"date-time":"2015-01-04T09:31:17Z","timestamp":1420363877000},"page":"213-226","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":225,"special_numbering":"C","title":["The Poly(I:C)-induced maternal immune activation model in preclinical neuropsychiatric drug discovery"],"prefix":"10.1016","volume":"149","author":[{"given":"Sonali","family":"Reisinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deeba","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eryan","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold","family":"Pollak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela D.","family":"Pollak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharmthera.2015.01.001_bb0005","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.schres.2009.11.008","article-title":"The effect of mirtazapine add on therapy to risperidone in the treatment of schizophrenia: a double-blind randomized placebo-controlled trial","volume":"116","author":"Abbasi","year":"2010","journal-title":"Schizophr Res"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0010","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1192\/bjp.163.4.522","article-title":"Epidemiological evidence that maternal influenza contributes to the aetiology of schizophrenia. An analysis of Scottish, English, and Danish data","volume":"163","author":"Adams","year":"1993","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0015","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/S1734-1140(13)71526-3","article-title":"Increased IL-6 trans-signaling in depression: focus on the tryptophan catabolite pathway, melatonin and neuroprogression","volume":"65","author":"Anderson","year":"2013","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0020","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.coph.2006.11.006","article-title":"Neurodevelopmental origins of depressive disorders","volume":"7","author":"Ansorge","year":"2007","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0025","doi-asserted-by":"crossref","DOI":"10.1186\/1742-2094-9-83","article-title":"Maternal immune activation by poly I:C induces expression of cytokines IL-1beta and IL-13, chemokine MCP-1 and colony stimulating factor VEGF in fetal mouse brain","volume":"9","author":"Arrode-Bruses","year":"2012","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0030","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1007\/s10803-010-1006-y","article-title":"Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders","volume":"40","author":"Atladottir","year":"2010","journal-title":"J Autism Dev Disord"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0035","first-page":"164","article-title":"Strain-dependent effects of prenatal maternal immune activation on anxiety- and depression-like behaviors in offspring","volume":"8","author":"Babri","year":"2013","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0040","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1176\/ajp.2006.163.5.927","article-title":"Prenatal exposure to maternal genital and reproductive infections and adult schizophrenia","volume":"163","author":"Babulas","year":"2006","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0045","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neulet.2010.10.074","article-title":"The phosphodiesterase type-5 inhibitor, tadalafil, improves depressive symptoms, ameliorates memory impairment, as well as suppresses apoptosis and enhances cell proliferation in the hippocampus of maternal-separated rat pups","volume":"488","author":"Baek","year":"2011","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0050","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.immunol.14.1.649","article-title":"The NF-kappa B and I kappa B proteins: new discoveries and insights","volume":"14","author":"Baldwin","year":"1996","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0055","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1001\/archpsyc.1990.01810210077012","article-title":"Exposure to influenza epidemics during gestation and adult schizophrenia. A 40-year study","volume":"47","author":"Barr","year":"1990","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0060","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/j.1471-4159.2007.04593.x","article-title":"Chronic lithium administration attenuates up-regulated brain arachidonic acid metabolism in a rat model of neuroinflammation","volume":"102","author":"Basselin","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0065","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.biopsych.2013.06.025","article-title":"Activation of the maternal immune system during pregnancy alters behavioral development of rhesus monkey offspring","volume":"75","author":"Bauman","year":"2014","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0070","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/2045-5380-1-9","article-title":"Criteria of validity for animal models of psychiatric disorders: focus on anxiety disorders and depression","volume":"1","author":"Belzung","year":"2011","journal-title":"Biol Mood Anxiety Disord"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0075","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1176\/appi.ajp.159.6.1018","article-title":"Neurocognitive effects of clozapine, olanzapine, risperidone, and haloperidol in patients with chronic schizophrenia or schizoaffective disorder","volume":"159","author":"Bilder","year":"2002","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0080","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s12031-007-0025-4","article-title":"Proteomic investigation of the ventral rat hippocampus links DRP-2 to escitalopram treatment resistance and SNAP to stress resilience in the chronic mild stress model of depression","volume":"32","author":"Bisgaard","year":"2007","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0085","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1038\/npp.2010.129","article-title":"Late prenatal immune activation in mice leads to behavioral and neurochemical abnormalities relevant to the negative symptoms of schizophrenia","volume":"35","author":"Bitanihirwe","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0090","doi-asserted-by":"crossref","DOI":"10.1097\/00006205-199211000-00018","article-title":"Extrapyramidal symptoms are serious side-effects of antipsychotic and other drugs","volume":"17","author":"Blair","year":"1992","journal-title":"Nurse Pract"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0095","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1176\/ajp.2006.163.10.1838","article-title":"Ethical concerns regarding olanzapine versus placebo in patients prodromally symptomatic for psychosis","volume":"163","author":"Block","year":"2006","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0100","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.bbi.2010.03.005","article-title":"Effects of prenatal infection on brain development and behavior: a review of findings from animal models","volume":"24","author":"Boksa","year":"2010","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0105","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1053\/plac.2001.0782","article-title":"Cytokines of the placenta and extra-placental membranes: roles and regulation during human pregnancy and parturition","volume":"23","author":"Bowen","year":"2002","journal-title":"Placenta"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0110","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.chc.2013.06.003","article-title":"Gray matter alterations in schizophrenia high-risk youth and early-onset schizophrenia: a review of structural MRI findings","volume":"22","author":"Brent","year":"2013","journal-title":"Child Adolesc Psychiatr Clin N Am"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0115","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1210\/en.2014-1040","article-title":"Prenatal stress-induced increases in placental inflammation and offspring hyperactivity are male-specific and ameliorated by maternal antiinflammatory treatment","volume":"155","author":"Bronson","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0120","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.pneurobio.2010.09.003","article-title":"The environment and susceptibility to schizophrenia","volume":"93","author":"Brown","year":"2011","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0125","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1001\/archpsyc.61.8.774","article-title":"Serologic evidence of prenatal influenza in the etiology of schizophrenia","volume":"61","author":"Brown","year":"2004","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0130","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1176\/appi.ajp.157.3.438","article-title":"Nonaffective psychosis after prenatal exposure to rubella","volume":"157","author":"Brown","year":"2000","journal-title":"Am J Psychiatry"},{"issue":"167","key":"10.1016\/j.pharmthera.2015.01.001_bb0145","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1176\/appi.ajp.2009.09030361","article-title":"Prenatal infection and schizophrenia: a review of epidemiologic and translational studies","volume":"1176","author":"Brown","year":"2010","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0150","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/mrdd.10004","article-title":"In utero infection and adult schizophrenia","volume":"8","author":"Brown","year":"2002","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0135","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1176\/appi.ajp.162.4.767","article-title":"Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring","volume":"162","author":"Brown","year":"2005","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0140","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/0006-3223(95)00241-8","article-title":"Affective disorders in Holland after prenatal exposure to the 1957 A2 influenza epidemic","volume":"38","author":"Brown","year":"1995","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0160","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/schbul\/sbn135","article-title":"Psychiatric comorbidities and schizophrenia","volume":"35","author":"Buckley","year":"2009","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0155","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1093\/oxfordjournals.schbul.a006901","article-title":"When symptoms persist: clozapine augmentation strategies","volume":"27","author":"Buckley","year":"2001","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0165","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.biopsych.2007.09.022","article-title":"Maternal exposure to herpes simplex virus and risk of psychosis among adult offspring","volume":"63","author":"Buka","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0170","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1001\/archpsyc.58.11.1032","article-title":"Maternal infections and subsequent psychosis among offspring","volume":"58","author":"Buka","year":"2001","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0175","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1600-0897.2012.01110.x","article-title":"Models of fetal brain injury, intrauterine inflammation, and preterm birth","volume":"67","author":"Burd","year":"2012","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0180","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.pneurobio.2011.08.006","article-title":"Purinergic signalling: from normal behaviour to pathological brain function","volume":"95","author":"Burnstock","year":"2011","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0185","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1017\/S1461145713000229","article-title":"Prenatal immune activation interacts with stress and corticosterone exposure later in life to modulate N-methyl-d-aspartate receptor synaptic function and plasticity","volume":"16","author":"Burt","year":"2013","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0190","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1046\/j.1440-1614.2001.01006.x","article-title":"No significant association between prenatal exposure poliovirus epidemics and psychosis","volume":"36","author":"Cahill","year":"2002","journal-title":"Aust N Z J Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0195","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1192\/bjp.168.3.368","article-title":"Prenatal exposure to the 1957 influenza epidemic and adult schizophrenia: a follow-up study","volume":"168","author":"Cannon","year":"1996","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0200","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1192\/bjp.180.6.496","article-title":"Perinatal and childhood risk factors for later criminality and violence in schizophrenia. Longitudinal, population-based study","volume":"180","author":"Cannon","year":"2002","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0205","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nm.3162","article-title":"Astrocyte-derived ATP modulates depressive-like behaviors","volume":"19","author":"Cao","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0210","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1161\/HYPERTENSIONAHA.111.172114","article-title":"Interleukin 10 deficiency exacerbates toll-like receptor 3-induced preeclampsia-like symptoms in mice","volume":"58","author":"Chatterjee","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0215","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neulet.2010.10.052","article-title":"Effects of polyinosinic\u2013polycytidylic acid (Poly I:C) on naloxone-precipitated withdrawal in morphine-dependent mice","volume":"487","author":"Chen","year":"2011","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0220","doi-asserted-by":"crossref","first-page":"519","DOI":"10.55782\/ane-2011-1868","article-title":"Lipopolysaccharide injected to pregnant mice affects behavior of their offspring in adulthood","volume":"71","author":"Chlodzinska","year":"2011","journal-title":"Acta Neurobiol Exp"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0225","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/sj.mp.4002106","article-title":"The DISC locus in psychiatric illness","volume":"13","author":"Chubb","year":"2008","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0230","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.placenta.2011.05.001","article-title":"How does variability of immune system genes affect placentation?","volume":"32","author":"Colucci","year":"2011","journal-title":"Placenta"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0235","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/S0006-3223(01)01271-9","article-title":"Management of treatment resistance in schizophrenia","volume":"50","author":"Conley","year":"2001","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0240","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.schres.2012.06.037","article-title":"Maternal immune activation alters behavior in adult offspring, with subtle changes in the cortical transcriptome and epigenome","volume":"140","author":"Connor","year":"2012","journal-title":"Schizophr Res"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0245","doi-asserted-by":"crossref","first-page":"546","DOI":"10.4088\/JCP.v68n0410","article-title":"Can antidepressants be used to treat the schizophrenia prodrome? Results of a prospective, naturalistic treatment study of adolescents","volume":"68","author":"Cornblatt","year":"2007","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0250","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1192\/bjp.161.3.390","article-title":"Prenatal exposure to influenza does not cause schizophrenia","volume":"161","author":"Crow","year":"1992","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0255","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.4088\/JCP.09r05021","article-title":"Adding psychotherapy to pharmacotherapy in the treatment of depressive disorders in adults: a meta-analysis","volume":"70","author":"Cuijpers","year":"2009","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0260","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1037\/a0013075","article-title":"Psychotherapy for depression in adults: a meta-analysis of comparative outcome studies","volume":"76","author":"Cuijpers","year":"2008","journal-title":"J Consult Clin Psychol"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0265","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.bbi.2006.12.007","article-title":"The sickness behaviour and CNS inflammatory mediator profile induced by systemic challenge of mice with synthetic double-stranded RNA (poly I:C)","volume":"21","author":"Cunningham","year":"2007","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0270","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1203\/01.pdr.0000230026.74139.18","article-title":"Interleukin-6 in the maternal circulation reaches the rat fetus in mid-gestation","volume":"60","author":"Dahlgren","year":"2006","journal-title":"Pediatr Res"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0275","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.brainresrev.2007.11.004","article-title":"Epigenetic programming of the stress response in male and female rats by prenatal restraint stress","volume":"57","author":"Darnaud\u00e9ry","year":"2008","journal-title":"Brain Res Rev"},{"issue":"Suppl. E1","key":"10.1016\/j.pharmthera.2015.01.001_bb0280","first-page":"e04","article-title":"Major depressive disorder treatment guidelines in America and Europe","volume":"71","author":"Davidson","year":"2010","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eurpsy.2006.10.008","article-title":"Relative efficacy of psychotherapy and combined therapy in the treatment of depression: a meta-analysis","volume":"22","author":"de Maat","year":"2007","journal-title":"Eur Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0290","doi-asserted-by":"crossref","first-page":"16091","DOI":"10.1523\/JNEUROSCI.2400-10.2010","article-title":"The Toll-like receptor-3 agonist polyinosinic:polycytidylic acid triggers nigrostriatal dopaminergic degeneration","volume":"30","author":"Deleidi","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0295","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neuron.2009.09.002","article-title":"Cytokines and CNS development","volume":"64","author":"Deverman","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0300","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3389\/fnbeh.2013.00217","article-title":"Aberrant neural synchrony in the maternal immune activation model: using translatable measures to explore targeted interventions","volume":"7","author":"Dickerson","year":"2013","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0305","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1742-2094-9-71","article-title":"Prenatal stress causes alterations in the morphology of microglia and the inflammatory response of the hippocampus of adult female mice","volume":"9","author":"Diz-Chaves","year":"2012","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0310","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.biopsych.2009.09.033","article-title":"A meta-analysis of cytokines in major depression","volume":"67","author":"Dowlati","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0315","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.neubiorev.2005.03.023","article-title":"Cytokines as mediators of depression: what can we learn from animal studies?","volume":"29","author":"Dunn","year":"2005","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0320","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3389\/fphar.2013.00146","article-title":"Mechanisms of antidepressant resistance","volume":"4","author":"El-Hage","year":"2013","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0325","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.schres.2010.05.014","article-title":"Structural brain alterations in schizophrenia following fetal exposure to the inflammatory cytokine interleukin-8","volume":"121","author":"Ellman","year":"2010","journal-title":"Schizophr Res"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijdevneu.2011.02.011","article-title":"Intrauterine inflammation, insufficient to induce parturition, still evokes fetal and neonatal brain injury","author":"Elovitz","year":"2011","journal-title":"Int J Dev Neurosci"},{"issue":"2\u20133","key":"10.1016\/j.pharmthera.2015.01.001_bb0335","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.brainresbull.2011.08.015","article-title":"Maternal infection during late pregnancy increases anxiety- and depression-like behaviors with increasing age in male offspring","volume":"87","author":"Enayati","year":"2012","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0340","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.schres.2009.01.008","article-title":"The relationship between the duration of untreated psychosis and outcome in low-and-middle income countries: a systematic review and meta analysis","volume":"109","author":"Farooq","year":"2009","journal-title":"Schizophr Res"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0350","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/sj.mp.4000520","article-title":"Defective corticogenesis and reduction in Reelin immunoreactivity in cortex and hippocampus of prenatally infected neonatal mice","volume":"4","author":"Fatemi","year":"1999","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0355","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/sj.mp.4001046","article-title":"Human influenza viral infection in utero alters glial fibrillary acidic protein immunoreactivity in the developing brains of neonatal mice","volume":"7","author":"Fatemi","year":"2002","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0345","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1023\/A:1015337611258","article-title":"Prenatal viral infection leads to pyramidal cell atrophy and macrocephaly in adulthood: implications for genesis of autism and schizophrenia","volume":"22","author":"Fatemi","year":"2002","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0360","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nrn2649","article-title":"Psychobiology and molecular genetics of resilience","volume":"10","author":"Feder","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0365","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1017\/S0033291704004167","article-title":"Suicidal behaviour in adolescence and subsequent mental health outcomes in young adulthood","volume":"35","author":"Fergusson","year":"2005","journal-title":"Psychol Med"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0370","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev-clinpsy-032210-104454","article-title":"Animal models of neuropsychiatric disorders","volume":"7","author":"Fernando","year":"2011","journal-title":"Annu Rev Clin Psychol"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0375","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1177\/08830738050200120301","article-title":"Neuropathologic substrate of cerebral palsy","volume":"20","author":"Folkerth","year":"2005","journal-title":"J Child Neurol"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0380","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.neubiorev.2008.03.003","article-title":"Behavioural and neurochemical effects of post-weaning social isolation in rodents\u2014relevance to developmental neuropsychiatric disorders","volume":"32","author":"Fone","year":"2008","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0385","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.bbr.2007.04.016","article-title":"Effects of prenatal infection on prepulse inhibition in the rat depend on the nature of the infectious agent and the stage of pregnancy","volume":"181","author":"Fortier","year":"2007","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0390","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1002\/dneu.22052","article-title":"Maternal and fetal antibrain antibodies in development and disease","volume":"72","author":"Fox","year":"2012","journal-title":"Dev Neurobiol"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0395","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.schres.2010.02.1071","article-title":"Who needs antipsychotic medication in the earliest stages of psychosis? A reconsideration of benefits, risks, neurobiology and ethics in the era of early intervention","volume":"119","author":"Francey","year":"2010","journal-title":"Schizophr Res"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0400","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bbi.2012.07.008","article-title":"Maternal immune activation causes age- and region-specific changes in brain cytokines in offspring throughout development","volume":"31","author":"Garay","year":"2013","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0405","first-page":"24","article-title":"Effects of maternal immune activation on gene expression patterns in the fetal brain","volume":"2012","author":"Garbett","year":"2012","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0410","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4088\/JCP.8133su1c.02","article-title":"Identifying difficult-to-treat depression: differential diagnosis, subtypes, and comorbidities","volume":"70","author":"Gaynes","year":"2009","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0415","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jneuroim.2004.10.008","article-title":"Maternal poly I:C exposure during pregnancy regulates TNF alpha, BDNF, and NGF expression in neonatal brain and the maternal\u2013fetal unit of the rat","volume":"159","author":"Gilmore","year":"2005","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0420","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1126\/science.1228261","article-title":"Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice","volume":"339","author":"Giovanoli","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0425","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0165-0327(97)00199-7","article-title":"A meta-analysis of the effects of cognitive therapy in depressed patients","volume":"49","author":"Gloaguen","year":"1998","journal-title":"J Affect Disord"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0430","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1038\/npp.2011.132","article-title":"The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a meta-analysis","volume":"36","author":"Hannestad","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0435","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.neuroscience.2010.01.006","article-title":"Prenatal exposure to lipopolysaccharide results in cognitive deficits in age-increasing offspring rats","volume":"166","author":"Hao","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0440","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1017\/S0033291712000128","article-title":"Interleukin-6, C-reactive protein and interleukin-10 after antidepressant treatment in people with depression: a meta-analysis","volume":"42","author":"Hiles","year":"2012","journal-title":"Psychol Med"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0445","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.bbi.2012.06.001","article-title":"A meta-analysis of differences in IL-6 and IL-10 between people with and without depression: exploring the causes of heterogeneity","volume":"26","author":"Hiles","year":"2012","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0450","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0893-133X(98)00006-2","article-title":"Effects of clozapine on in vitro immune parameters: a longitudinal study in clozapine-treated schizophrenic patients","volume":"19","author":"Hinze-Selch","year":"1998","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0455","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1176\/appi.ajp.157.5.808","article-title":"Untreated initial psychosis: its relation to quality of life and symptom remission in first-episode schizophrenia","volume":"157","author":"Ho","year":"2000","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0460","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1001\/archpsyc.60.6.585","article-title":"Progressive structural brain abnormalities and their relationship to clinical outcome: a longitudinal magnetic resonance imaging study early in schizophrenia","volume":"60","author":"Ho","year":"2003","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0465","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jneuroim.2007.07.021","article-title":"Prenatal exposure to a pro-inflammatory stimulus causes delays in the development of the innate immune response to LPS in the offspring","volume":"190","author":"Hodyl","year":"2007","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0470","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/bdrb.10035","article-title":"Species comparison of anatomical and functional immune system development","volume":"68","author":"Holsapple","year":"2003","journal-title":"Birth Defects Res B Dev Reprod Toxicol"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0475","doi-asserted-by":"crossref","first-page":"e83149","DOI":"10.1371\/journal.pone.0083149","article-title":"Concomitant interferon alpha stimulation and TLR3 activation induces neuronal expression of depression-related genes that are elevated in the brain of suicidal persons","volume":"8","author":"Hoyo-Becerra","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0480","doi-asserted-by":"crossref","first-page":"12776","DOI":"10.1073\/pnas.1202556109","article-title":"Modeling an autism risk factor in mice leads to permanent immune dysregulation","volume":"109","author":"Hsiao","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0485","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.tins.2009.05.007","article-title":"Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1","volume":"32","author":"Jaaro-Peled","year":"2009","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0490","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ijdevneu.2007.08.017","article-title":"The effects of maternal inflammation on neuronal development: possible mechanisms","volume":"25","author":"Jonakait","year":"2007","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0495","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fnmol.2011.00016","article-title":"Glycogen synthase kinase-3 in the etiology and treatment of mood disorders","volume":"4","author":"Jope","year":"2011","journal-title":"Front Mol Neurosci"},{"issue":"Suppl. 12","key":"10.1016\/j.pharmthera.2015.01.001_bb0500","first-page":"5","article-title":"The expert consensus guideline series. Optimizing pharmacologic treatment of psychotic disorders. Introduction: methods, commentary, and summary","volume":"64","author":"Kane","year":"2003","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0505","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.bbi.2014.03.020","article-title":"Expression of Toll-like receptors in peripheral blood mononuclear cells and response to cognitive\u2013behavioral therapy in major depressive disorder","volume":"40","author":"Keri","year":"2014","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0510","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1001\/jama.289.23.3095","article-title":"The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R)","volume":"289","author":"Kessler","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0515","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/tp.2013.132","article-title":"Long-term effects of maternal immune activation on depression-like behavior in the mouse","volume":"4","author":"Khan","year":"2014","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0520","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1017\/S0033291712000736","article-title":"Prenatal maternal infection, neurodevelopment and adult schizophrenia: a systematic review of population-based studies","volume":"43","author":"Khandaker","year":"2013","journal-title":"Psychol Med"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0525","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0893-133X(01)00396-7","article-title":"Glucocorticoid hormones and early brain development in schizophrenia","volume":"27","author":"Koenig","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0530","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1073\/pnas.0910658107","article-title":"Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior","volume":"107","author":"Koo","year":"2010","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0535","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/sj.npp.1300027","article-title":"H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs","volume":"28","author":"Kroeze","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0540","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/00004714-200104000-00012","article-title":"Anti-inflammatory effects of antidepressants through suppression of the interferon-gamma\/interleukin-10 production ratio","volume":"21","author":"Kubera","year":"2001","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0545","article-title":"Handbook of Neurochemistry and Molecular Neurobiology","author":"Lajtha","year":"2008"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0550","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1146\/annurev.neuro.25.112701.142754","article-title":"Schizophrenia as a disorder of neurodevelopment","volume":"25","author":"Lewis","year":"2002","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0555","doi-asserted-by":"crossref","first-page":"e6354","DOI":"10.1371\/journal.pone.0006354","article-title":"Prenatal immune challenge is an environmental risk factor for brain and behavior change relevant to schizophrenia: evidence from MRI in a mouse model","volume":"4","author":"Li","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0560","doi-asserted-by":"crossref","first-page":"e4660","DOI":"10.1371\/journal.pone.0004660","article-title":"Transplacental passage of interleukins 4 and 13?","volume":"4","author":"Lim","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0565","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1034\/j.1600-0447.2003.00052.x","article-title":"Prenatal exposure to influenza as a risk factor for adult schizophrenia","volume":"107","author":"Limosin","year":"2003","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0570","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3389\/fncel.2014.00087","article-title":"Sarm1 deficiency impairs synaptic function and leads to behavioral deficits, which can be ameliorated by an mGluR allosteric modulator","volume":"8","author":"Lin","year":"2014","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0575","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.bbi.2013.12.002","article-title":"Sarm1, a neuronal inflammatory regulator, controls social interaction, associative memory and cognitive flexibility in mice","volume":"37","author":"Lin","year":"2014","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0580","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.bbi.2011.12.003","article-title":"Prenatal lipopolysaccharide exposure increases anxiety-like behaviors and enhances stress-induced corticosterone responses in adult rats","volume":"26","author":"Lin","year":"2012","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0585","article-title":"Prenatal lipopolysaccharide exposure increases depression-like behaviors and reduces hippocampal neurogenesis in adult rats","volume":"4328","author":"Lin","year":"2013","journal-title":"Behav Brain Res"},{"issue":"18","key":"10.1016\/j.pharmthera.2015.01.001_bb0590","doi-asserted-by":"crossref","first-page":"7654","DOI":"10.1523\/JNEUROSCI.0091-13.2013","article-title":"Maternal immune activation during gestation interacts with Disc1 point mutation to exacerbate schizophrenia-related behaviors in mice","volume":"33","author":"Lipina","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0595","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.bbr.2009.01.031","article-title":"Gestational methylazoxymethanol acetate administration: a developmental disruption model of schizophrenia","volume":"204","author":"Lodge","year":"2009","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0600","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.pharmthera.2009.02.010","article-title":"Ketamine and the next generation of antidepressants with a rapid onset of action","volume":"123","author":"Machado-Vieira","year":"2009","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0605","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1001\/archpsyc.1997.01830160040006","article-title":"Adult major affective disorder after prenatal exposure to an influenza epidemic","volume":"54","author":"Machon","year":"1997","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0610","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1006\/cyto.1997.0238","article-title":"Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression","volume":"9","author":"Maes","year":"1997","journal-title":"Cytokine"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0615","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.psyneuen.2010.05.012","article-title":"Voluntary exercise and palatable high-fat diet both improve behavioural profile and stress responses in male rats exposed to early life stress: role of hippocampus","volume":"35","author":"Maniam","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0620","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3389\/fnbeh.2011.00063","article-title":"Endocannabinoid system and psychiatry: in search of a neurobiological basis for detrimental and potential therapeutic effects","volume":"5","author":"Marco","year":"2011","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0625","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00213-010-2035-0","article-title":"Prenatal stress: role in psychotic and depressive diseases","volume":"214","author":"Markham","year":"2011","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0630","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.neuropharm.2011.03.003","article-title":"Influence of social isolation in the rat on serotonergic function and memory\u2014relevance to models of schizophrenia and the role of 5-HT(6) receptors","volume":"61","author":"Marsden","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0635","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1001\/archpsyc.62.9.975","article-title":"Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systematic review","volume":"62","author":"Marshall","year":"2005","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0640","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.bbi.2007.12.007","article-title":"Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism","volume":"22","author":"Martin","year":"2008","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0645","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0006-3223(01)01209-4","article-title":"Cytokine effects on cortical neuron MAP-2 immunoreactivity: implications for schizophrenia","volume":"50","author":"Marx","year":"2001","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0650","doi-asserted-by":"crossref","first-page":"913","DOI":"10.2165\/11595900-000000000-00000","article-title":"The hippocampus, neurotrophic factors and depression: possible implications for the pharmacotherapy of depression","volume":"25","author":"Masi","year":"2011","journal-title":"CNS"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0655","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.addr.2007.11.005","article-title":"TLR3: interferon induction by double-stranded RNA including poly(I:C)","volume":"60","author":"Matsumoto","year":"2008","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0660","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bbi.2014.01.019","article-title":"Minocycline rescues decrease in neurogenesis, increase in microglia cytokines and deficits in sensorimotor gating in an animal model of schizophrenia","volume":"38","author":"Mattei","year":"2014","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0665","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.neuron.2005.02.014","article-title":"Deep brain stimulation for treatment-resistant depression","volume":"45","author":"Mayberg","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0670","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/schbul\/20.2.263","article-title":"Prenatal influenza infections and adult schizophrenia","volume":"20","author":"Mednick","year":"1994","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0675","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1001\/archpsyc.1988.01800260109013","article-title":"Adult schizophrenia following prenatal exposure to an influenza epidemic","volume":"45","author":"Mednick","year":"1988","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0680","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0065-3233(08)60437-4","article-title":"Cytokines in brain development and function","volume":"52","author":"Mehler","year":"1998","journal-title":"Adv Protein Chem"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0685","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1001\/archpsyc.65.6.634","article-title":"Prevention of negative symptom psychopathologies in first-episode schizophrenia: two-year effects of reducing the duration of untreated psychosis","volume":"65","author":"Melle","year":"2008","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0690","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1176\/appi.ajp.2014.14010095","article-title":"New serological evidence points toward an infectious route to bipolar disorder","volume":"171","author":"Meyer","year":"2014","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0695","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.biopsych.2013.07.011","article-title":"Prenatal poly(i:C) exposure and other developmental immune activation models in rodent systems","volume":"75","author":"Meyer","year":"2014","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0700","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.pneurobio.2009.10.018","article-title":"Epidemiology-driven neurodevelopmental animal models of schizophrenia","volume":"90","author":"Meyer","year":"2010","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0705","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/j.neuropharm.2011.01.009","article-title":"To poly(I:C) or not to poly(I:C): advancing preclinical schizophrenia research through the use of prenatal immune activation models","volume":"62","author":"Meyer","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0710","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.neubiorev.2009.05.001","article-title":"In-vivo rodent models for the experimental investigation of prenatal immune activation effects in neurodevelopmental brain disorders","volume":"33","author":"Meyer","year":"2009","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0715","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.neubiorev.2004.10.012","article-title":"Towards an immuno-precipitated neurodevelopmental animal model of schizophrenia","volume":"29","author":"Meyer","year":"2005","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0720","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.bbi.2005.11.003","article-title":"Immunological stress at the maternal\u2013foetal interface: a link between neurodevelopment and adult psychopathology","volume":"20","author":"Meyer","year":"2006","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0725","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/schbul\/sbn022","article-title":"A review of the fetal brain cytokine imbalance hypothesis of schizophrenia","volume":"35","author":"Meyer","year":"2009","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0730","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00213-009-1754-6","article-title":"Chronic clozapine treatment improves prenatal infection-induced working memory deficits without influencing adult hippocampal neurogenesis","volume":"208","author":"Meyer","year":"2010","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0735","doi-asserted-by":"crossref","first-page":"4752","DOI":"10.1523\/JNEUROSCI.0099-06.2006","article-title":"The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology","volume":"26","author":"Meyer","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0740","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/sj.npp.1301413","article-title":"Relative prenatal and postnatal maternal contributions to schizophrenia-related neurochemical dysfunction after in utero immune challenge","volume":"33","author":"Meyer","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0745","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.bbi.2007.09.012","article-title":"Adult brain and behavioral pathological markers of prenatal immune challenge during early\/middle and late fetal development in mice","volume":"22","author":"Meyer","year":"2008","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0750","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1093\/schbul\/sbn131","article-title":"Evaluating early preventive antipsychotic and antidepressant drug treatment in an infection-based neurodevelopmental mouse model of schizophrenia","volume":"36","author":"Meyer","year":"2010","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0755","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1177\/1073858406296401","article-title":"The neurodevelopmental impact of prenatal infections at different times of pregnancy: the earlier the worse?","volume":"13","author":"Meyer","year":"2007","journal-title":"Neuroscientist"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0760","first-page":"135049","article-title":"Comparing the effects of repetitive transcranial magnetic stimulation and electroconvulsive therapy in the treatment of depression: a systematic review and meta-analysis","volume":"2014","author":"Micallef-Trigona","year":"2014","journal-title":"Depress Res Treat"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0765","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1002\/dneu.22044","article-title":"Immune system gene dysregulation in autism and schizophrenia","volume":"72","author":"Michel","year":"2012","journal-title":"Dev Neurobiol"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0770","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1046\/j.1440-1819.2000.00638.x","article-title":"Mood disorders and influenza epidemics in Japan","volume":"54","author":"Mino","year":"2000","journal-title":"Psychiatry Clin Neurosci"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0775","first-page":"00170","article-title":"The risk for behavioural deficits is determined by the maternal immune response to prenatal immune challenge in a neurodevelopmental model","volume":"26","author":"Missault","year":"2014","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0780","article-title":"Fluoxetine signature on hippocampal MAPK signalling in sex-dependent manner","author":"Mitic","year":"2014","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0785","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nri1897","article-title":"Immunology of placentation in eutherian mammals","volume":"6","author":"Moffett","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0790","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.bbi.2012.12.011","article-title":"Social isolation rearing induces mitochondrial, immunological, neurochemical and behavioural deficits in rats, and is reversed by clozapine or N-acetyl cysteine","volume":"30","author":"Moller","year":"2013","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0800","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.biopsych.2006.05.024","article-title":"Toxoplasma gondii as a risk factor for early-onset schizophrenia: analysis of filter paper blood samples obtained at birth","volume":"61","author":"Mortensen","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0805","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/00002826-200601000-00009","article-title":"Augmentation strategies of clozapine with antipsychotics in the treatment of ultraresistant schizophrenia","volume":"29","author":"Mouaffak","year":"2006","journal-title":"Clin Neuropharmacol"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0810","doi-asserted-by":"crossref","first-page":"9055","DOI":"10.1523\/JNEUROSCI.1424-08.2008","article-title":"Sex-specific programming of offspring emotionality after stress early in pregnancy","volume":"28","author":"Mueller","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0815","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.psychres.2011.12.049","article-title":"Impaired monocyte activation in schizophrenia","volume":"198","author":"Muller","year":"2012","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0820","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1126\/science.281.5380.1191","article-title":"Prevention of allogeneic fetal rejection by tryptophan catabolism","volume":"281","author":"Munn","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0825","doi-asserted-by":"crossref","first-page":"e400","DOI":"10.1038\/tp.2014.33","article-title":"Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy","volume":"4","author":"Naviaux","year":"2014","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0830","doi-asserted-by":"crossref","first-page":"e57380","DOI":"10.1371\/journal.pone.0057380","article-title":"Antipurinergic therapy corrects the autism-like features in the poly(IC) mouse model","volume":"8","author":"Naviaux","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0835","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/nn.2647","article-title":"Animal models of neuropsychiatric disorders","volume":"13","author":"Nestler","year":"2010","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0840","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neuroscience.2006.07.029","article-title":"Maternal immune activation during pregnancy increases limbic GABAA receptor immunoreactivity in the adult offspring: implications for schizophrenia","volume":"143","author":"Nyffeler","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0845","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/0140-6736(91)92919-S","article-title":"Schizophrenia after prenatal exposure to 1957 A2 influenza epidemic","volume":"337","author":"O'Callaghan","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0850","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1034\/j.1600-0897.2003.01150.x","article-title":"Demonstration of the presence of IL-16, IL-17 and IL-18 at the murine fetomaternal interface during murine pregnancy","volume":"49","author":"Ostojic","year":"2003","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0855","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.biopsych.2005.07.031","article-title":"Immune activation during pregnancy in mice leads to dopaminergic hyperfunction and cognitive impairment in the offspring: a neurodevelopmental animal model of schizophrenia","volume":"59","author":"Ozawa","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0860","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1001\/archpsyc.61.7.714","article-title":"Combined pharmacotherapy and psychological treatment for depression: a systematic review","volume":"61","author":"Pampallona","year":"2004","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0865","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jpsychires.2014.01.021","article-title":"Toll-like receptors in the depressed and suicide brain","volume":"53","author":"Pandey","year":"2014","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0870","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1177\/070674370905400809","article-title":"No association between prenatal viral infection and depression in later life\u2014a long-term cohort study of 6152 subjects","volume":"54","author":"Pang","year":"2009","journal-title":"Can J Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0875","doi-asserted-by":"crossref","first-page":"652","DOI":"10.3109\/10253890.2011.628719","article-title":"Immune stress in late pregnant rats decreases length of gestation and fecundity, and alters later cognitive and affective behaviour of surviving pre-adolescent offspring","volume":"14","author":"Paris","year":"2011","journal-title":"Stress"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0880","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/glia.20278","article-title":"TLR3-mediated signal induces proinflammatory cytokine and chemokine gene expression in astrocytes: differential signaling mechanisms of TLR3-induced IP-10 and IL-8 gene expression","volume":"53","author":"Park","year":"2006","journal-title":"Glia"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0885","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1126\/science.1150196","article-title":"Neuroscience. Maternal effects on schizophrenia risk","volume":"318","author":"Patterson","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0890","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1176\/appi.ajp.162.10.1785","article-title":"Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis","volume":"162","author":"Perkins","year":"2005","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0895","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/ana.23898","article-title":"Maternal immune activation promotes hippocampal kindling epileptogenesis in mice","volume":"74","author":"Pineda","year":"2013","journal-title":"Ann Neurol"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0900","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1093\/schbul\/sbq040","article-title":"Risperidone administered during asymptomatic period of adolescence prevents the emergence of brain structural pathology and behavioral abnormalities in an animal model of schizophrenia","volume":"37","author":"Piontkewitz","year":"2011","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0905","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.neuropharm.2011.04.019","article-title":"Tracing the development of psychosis and its prevention: what can be learned from animal models","volume":"62","author":"Piontkewitz","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0910","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.biopsych.2009.07.005","article-title":"Clozapine administration in adolescence prevents postpubertal emergence of brain structural pathology in an animal model of schizophrenia","volume":"66","author":"Piontkewitz","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0915","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3109\/07853891003769957","article-title":"Rodent models in depression research: classical strategies and new directions","volume":"42","author":"Pollak","year":"2010","journal-title":"Ann Med"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0920","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s004410051285","article-title":"Cytokine-induced conversion of mesencephalic-derived progenitor cells into dopamine neurons","volume":"296","author":"Potter","year":"1999","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0925","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/nrd3649","article-title":"Advancing schizophrenia drug discovery: optimizing rodent models to bridge the translational gap","volume":"11","author":"Pratt","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0930","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/sj.mp.4001642","article-title":"The neurodevelopmental model of schizophrenia: update 2005","volume":"10","author":"Rapoport","year":"2005","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0935","article-title":"Cerebral palsy and placental infection: a case\u2013cohort study","volume":"4","author":"Rasiah Vigneswaran","year":"2003","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0940","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jpsychires.2014.04.010","article-title":"MAPK signaling correlates with the antidepressant effects of ketamine","volume":"55","author":"Reus","year":"2014","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0945","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.physbeh.2012.02.004","article-title":"Fluoxetine and aripiprazole treatment following prenatal immune activation exert longstanding effects on rat locomotor response","volume":"106","author":"Richtand","year":"2012","journal-title":"Physiol Behav"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0950","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neulet.2011.06.011","article-title":"Effect of paliperidone and risperidone on extracellular glutamate in the prefrontal cortex of rats exposed to prenatal immune activation or MK-801","volume":"500","author":"Roenker","year":"2011","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0955","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1038\/sj.npp.1301292","article-title":"Neurobehavioral and immunological consequences of prenatal immune activation in rats. Influence of antipsychotics","volume":"32","author":"Romero","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0960","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.schres.2010.03.015","article-title":"Probably at-risk, but certainly ill\u2014advocating the introduction of a psychosis spectrum disorder in DSM-V","volume":"120","author":"Ruhrmann","year":"2010","journal-title":"Schizophr Res"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0965","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1176\/ajp.2006.163.11.1905","article-title":"Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report","volume":"163","author":"Rush","year":"2006","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0970","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0027-5107(97)00178-4","article-title":"Developmental toxicity induced during early stages of mammalian embryogenesis","volume":"396","author":"Rutledge","year":"1997","journal-title":"Mutat Res"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0975","first-page":"85","article-title":"Maternal and fetal immune responses during pregnancy","volume":"10","author":"Sargent","year":"1993","journal-title":"Exp Clin Immunogenet"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0980","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1177\/070674371305800107","article-title":"The significance of at-risk symptoms for psychosis in children and adolescents","volume":"58","author":"Schimmelmann","year":"2013","journal-title":"Can J Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0985","doi-asserted-by":"crossref","first-page":"e38668","DOI":"10.1371\/journal.pone.0038668","article-title":"Selective hyper-responsiveness of the interferon system in major depressive disorders and depression induced by interferon therapy","volume":"7","author":"Schlaak","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0990","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.biopsych.2013.01.034","article-title":"Rapid effects of deep brain stimulation for treatment-resistant major depression","volume":"73","author":"Schlaepfer","year":"2013","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb0995","doi-asserted-by":"crossref","first-page":"e240","DOI":"10.1038\/tp.2013.16","article-title":"Maternal immune activation and strain specific interactions in the development of autism-like behaviors in mice","volume":"3","author":"Schwartzer","year":"2013","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1000","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11689-008-9000-9","article-title":"Deficient maternal care resulting from immunological stress during pregnancy is associated with a sex-dependent enhancement of conditioned fear in the offspring","volume":"1","author":"Schwendener","year":"2009","journal-title":"J Neurodev Disord"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1005","doi-asserted-by":"crossref","first-page":"U49","DOI":"10.1530\/eje.0.151U049","article-title":"Prenatal glucocorticoids and long-term programming","volume":"151","author":"Seckl","year":"2004","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1010","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s40263-013-0097-3","article-title":"Current place of monoamine oxidase inhibitors in the treatment of depression","volume":"27","author":"Shulman","year":"2013","journal-title":"CNS Drugs"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1015","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0893-133X(01)00426-2","article-title":"Surgically implantable long-term antipsychotic delivery systems for the treatment of schizophrenia","volume":"26","author":"Siegel","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1020","doi-asserted-by":"crossref","first-page":"10695","DOI":"10.1523\/JNEUROSCI.2178-07.2007","article-title":"Maternal immune activation alters fetal brain development through interleukin-6","volume":"27","author":"Smith","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1025","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/schbul\/sbn121","article-title":"Association between prenatal exposure to bacterial infection and risk of schizophrenia","volume":"35","author":"Sorensen","year":"2009","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1030","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1177\/070674371305800703","article-title":"Psychotherapy, antidepressants, and their combination for chronic major depressive disorder: a systematic review","volume":"58","author":"Spijker","year":"2013","journal-title":"Can J Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1035","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1176\/ajp.151.6.922","article-title":"No relation between risk of schizophrenia and prenatal exposure to influenza in Holland","volume":"151","author":"Susser","year":"1994","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1040","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1176\/ajp.156.7.1100","article-title":"Association between prenatal exposure to poliovirus infection and adult schizophrenia","volume":"156","author":"Suvisaari","year":"1999","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1045","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1600-0447.1993.tb03468.x","article-title":"Does prenatal influenza divert susceptible females from later affective psychosis to schizophrenia?","volume":"88","author":"Takei","year":"1993","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1050","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/sj.mp.4002145","article-title":"Intermediate phenotypes in schizophrenia genetics redux: is it a no brainer?","volume":"13","author":"Tan","year":"2008","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1055","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bbi.2013.01.086","article-title":"Epigenetic changes at gene promoters in response to immune activation in utero","volume":"30","author":"Tang","year":"2013","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1060","series-title":"The House Mouse","author":"Theiler","year":"1972"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1065","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/ajh.2009.125","article-title":"Immunosuppression improves blood pressure and endothelial function in a rat model of pregnancy-induced hypertension","volume":"22","author":"Tinsley","year":"2009","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1070","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0920-9964(88)90043-6","article-title":"Schizophrenic births and viral diseases in two states","volume":"1","author":"Torrey","year":"1988","journal-title":"Schizophr Res"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1075","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.neuron.2010.12.023","article-title":"Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events","volume":"69","author":"Uchida","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1080","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.jad.2013.06.004","article-title":"CRP, IL-6 and depression: a systematic review and meta-analysis of longitudinal studies","volume":"150","author":"Valkanova","year":"2013","journal-title":"J Affect Disord"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1085","first-page":"005","article-title":"Hypolocomotive behaviour associated with increased microglia in a prenatal immune activation model with relevance to schizophrenia","volume":"4328","author":"Van den Eynde","year":"2013","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1090","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1471-244X-13-22","article-title":"The effectiveness of individual interpersonal psychotherapy as a treatment for major depressive disorder in adult outpatients: a systematic review","volume":"13","author":"van Hees","year":"2013","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1095","first-page":"00145","article-title":"Prenatal poly I:C age-dependently alters cannabinoid type 1 receptors in offspring: a longitudinal small animal PET study using [F]MK-9470","volume":"10","author":"Verdurand","year":"2014","journal-title":"Exp Neurol"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1100","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/S1734-1140(13)71505-6","article-title":"Early maternal separation: a rodent model of depression and a prevailing human condition","volume":"65","author":"Vetulani","year":"2013","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1105","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/syn.21561","article-title":"Prenatal immune challenge in rats: altered responses to dopaminergic and glutamatergic agents, prepulse inhibition of acoustic startle, and reduced route-based learning as a function of maternal body weight gain after prenatal exposure to poly IC","volume":"66","author":"Vorhees","year":"2012","journal-title":"Synapse"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1110","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1523\/JNEUROSCI.4831-11.2012","article-title":"Prenatal immune activation interacts with genetic Nurr1 deficiency in the development of attentional impairments","volume":"32","author":"Vuillermot","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1115","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1523\/JNEUROSCI.5408-09.2010","article-title":"A longitudinal examination of the neurodevelopmental impact of prenatal immune activation in mice reveals primary defects in dopaminergic development relevant to schizophrenia","volume":"30","author":"Vuillermot","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1120","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s11920-007-0061-3","article-title":"The STAR*D Project results: a comprehensive review of findings","volume":"9","author":"Warden","year":"2007","journal-title":"Curr Psychiatry Rep"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1125","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1001\/archpsyc.1984.01790120089011","article-title":"Schizophrenic birth seasonality in relation to the incidence of infectious diseases and temperature extremes","volume":"41","author":"Watson","year":"1984","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1130","doi-asserted-by":"crossref","first-page":"e35035","DOI":"10.1371\/journal.pone.0035035","article-title":"MAPK signaling determines anxiety in the juvenile mouse brain but depression-like behavior in adults","volume":"7","author":"Wefers","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1135","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1046\/j.1460-9568.2000.00958.x","article-title":"Inhibition of 11beta-hydroxysteroid dehydrogenase, the foeto-placental barrier to maternal glucocorticoids, permanently programs amygdala GR mRNA expression and anxiety-like behaviour in the offspring","volume":"12","author":"Welberg","year":"2000","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1140","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neuropharm.2013.05.012","article-title":"Altered GSK3beta signaling in an infection-based mouse model of developmental neuropsychiatric disease","volume":"73","author":"Willi","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1145","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s002130050456","article-title":"Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation","volume":"134","author":"Willner","year":"1997","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1150","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1017\/S1461145708009206","article-title":"Prenatal immune activation leads to multiple changes in basal neurotransmitter levels in the adult brain: implications for brain disorders of neurodevelopmental origin such as schizophrenia","volume":"12","author":"Winter","year":"2009","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1155","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1124\/jpet.104.080200","article-title":"Clozapine potentiation of N-methyl-d-aspartate receptor currents in the nucleus accumbens: role of NR2B and protein kinase A\/Src kinases","volume":"313","author":"Wittmann","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1160","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.bbr.2010.05.008","article-title":"The maternal immune activation (MIA) model of schizophrenia produces pre-pulse inhibition (PPI) deficits in both juvenile and adult rats but these effects are not associated with maternal weight loss","volume":"213","author":"Wolff","year":"2010","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1165","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00213-011-2315-3","article-title":"Dipyridamole monotherapy in schizophrenia: pilot of a novel treatment approach by modulation of purinergic signaling","volume":"218","author":"Wonodi","year":"2011","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1170","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.schres.2008.07.012","article-title":"Validation of \u201cprodromal\u201d criteria to detect individuals at ultra high risk of psychosis: 2 year follow-up","volume":"105","author":"Yung","year":"2008","journal-title":"Schizophr Res"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1175","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.neuropharm.2011.02.022","article-title":"Prenatal exposure to a viral mimetic alters behavioural flexibility in male, but not female, rats","volume":"62","author":"Zhang","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1180","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/(SICI)1097-4547(19980401)52:1<7::AID-JNR2>3.0.CO;2-I","article-title":"Involvement of cytokines in normal CNS development and neurological diseases: recent progress and perspectives","volume":"52","author":"Zhao","year":"1998","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1185","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.psychres.2014.06.046","article-title":"Minocycline alleviates behavioral deficits and inhibits microglial activation in the offspring of pregnant mice after administration of polyriboinosinic\u2013polyribocytidilic acid","volume":"219","author":"Zhu","year":"2014","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1190","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1176\/ajp.154.6.782","article-title":"Controlled, dose\u2013response study of sertindole and haloperidol in the treatment of schizophrenia. Sertindole Study Group","volume":"154","author":"Zimbroff","year":"1997","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1195","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1046\/j.1365-2249.2001.01607.x","article-title":"Localization of pro-inflammatory (IL-12, IL-15) and anti-inflammatory (IL-11, IL-13) cytokines at the foetomaternal interface during murine pregnancy","volume":"126","author":"Zourbas","year":"2001","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.pharmthera.2015.01.001_bb1200","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1038\/sj.npp.1300248","article-title":"Immune activation during pregnancy in rats leads to a postpubertal emergence of disrupted latent inhibition, dopaminergic hyperfunction, and altered limbic morphology in the offspring: a novel neurodevelopmental model of schizophrenia","volume":"28","author":"Zuckerman","year":"2003","journal-title":"Neuropsychopharmacology"}],"container-title":["Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725815000029?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725815000029?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T07:46:18Z","timestamp":1717659978000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725815000029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":239,"alternative-id":["S0163725815000029"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2015.01.001","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Poly(I:C)-induced maternal immune activation model in preclinical neuropsychiatric drug discovery","name":"articletitle","label":"Article Title"},{"value":"Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmthera.2015.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}